pyrrolidine-2,4-dicarboxylic acid has been researched along with Epilepsy in 3 studies
pyrrolidine-2,4-dicarboxylic acid: a glutamate uptake inhibitor
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "When pilocarpine was administered to this group of rats, there were further selective, significant, transient increases in the extracellular levels of aspartate (31%) and glutamate (18%) which preceded the onset of seizures." | 1.29 | Extracellular amino acid levels in hippocampus during pilocarpine-induced seizures. ( Chapman, AG; Meldrum, BS; Millan, MH, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nyitrai, G | 1 |
| Lasztóczi, B | 1 |
| Kardos, J | 1 |
| Millan, MH | 1 |
| Chapman, AG | 1 |
| Meldrum, BS | 1 |
| Claudio, OI | 1 |
| Ferchmin, P | 1 |
| Velísek, L | 1 |
| Sperber, EF | 1 |
| Moshé, SL | 1 |
| Ortiz, JG | 1 |
3 other studies available for pyrrolidine-2,4-dicarboxylic acid and Epilepsy
| Article | Year |
|---|---|
Glutamate uptake shapes low-[Mg2+] induced epileptiform activity in juvenile rat hippocampal slices.
Topics: Aging; Animals; Aspartic Acid; CA3 Region, Hippocampal; Dicarboxylic Acids; Dose-Response Relationsh | 2010 |
Extracellular amino acid levels in hippocampus during pilocarpine-induced seizures.
Topics: Amino Acids; Animals; Behavior, Animal; Dialysis; Dicarboxylic Acids; Epilepsy; Glutamates; Glutamic | 1993 |
Plasticity of excitatory amino acid transporters in experimental epilepsy.
Topics: Animals; Dicarboxylic Acids; Epilepsy; Female; Glutamic Acid; Hippocampus; Kainic Acid; Magnesium; N | 2000 |