pyrrolidine-2,4-dicarboxylic acid has been researched along with Amyotrophic Lateral Sclerosis in 3 studies
pyrrolidine-2,4-dicarboxylic acid: a glutamate uptake inhibitor
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tovar-y-Romo, LB | 1 |
| Tapia, R | 1 |
| Rattray, M | 1 |
| Bendotti, C | 1 |
| Urushitani, M | 1 |
| Shimohama, S | 1 |
| Kihara, T | 1 |
| Sawada, H | 1 |
| Akaike, A | 1 |
| Ibi, M | 1 |
| Inoue, R | 1 |
| Kitamura, Y | 1 |
| Taniguchi, T | 1 |
| Kimura, J | 1 |
3 other studies available for pyrrolidine-2,4-dicarboxylic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Cerebral neurons of transgenic ALS mice are vulnerable to glutamate release stimulation but not to increased extracellular glutamate due to transport blockade.
Topics: 4-Aminopyridine; Amyotrophic Lateral Sclerosis; Animals; Biological Transport; Dicarboxylic Acids; D | 2006 |
Does excitotoxic cell death of motor neurons in ALS arise from glutamate transporter and glutamate receptor abnormalities?
Topics: Amyotrophic Lateral Sclerosis; Animals; Biological Transport; Cell Death; Dicarboxylic Acids; Diseas | 2006 |
Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: involvement of glutamate-induced nitric oxide in motor neuron toxicity and nonmotor neuron protection.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Death; Cell Survival; Cells, Cultured; Cyclic GMP; Dica | 1998 |