Page last updated: 2024-08-18

pyrroles and Schizophrenia

pyrroles has been researched along with Schizophrenia in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-199013 (44.83)18.7374
1990's2 (6.90)18.2507
2000's5 (17.24)29.6817
2010's6 (20.69)24.3611
2020's3 (10.34)2.80

Authors

AuthorsStudies
Aricioglu, F; Bekci, H; Cumaoglu, A; Unal, G; Yerer, MB1
Aricioglu, F; Sirvanci, S; Unal, G1
Mulder, RT; Rucklidge, JJ; Sarris, J; Warren, B1
Meltzer, HY; Miyauchi, M; Neugebauer, NM1
Dutta, S; Florian, H; Gertsik, L; Haig, G; Locke, C; Othman, AA1
Bain, E; Baker, J; Haig, GM; Lenz, RA; Othman, AA; Robieson, W1
Conn, PJ; Daniels, JS; Dickerson, JW; Ghoshal, A; Jalan-Sakrikar, N; Jones, CK; Lamsal, A; Lindsley, CW; Melancon, BJ; Morrison, RD; Niswender, CM; Noetzel, MJ; Poslusney, MS; Rook, JM; Roop, GN; Stauffer, SR; Wood, MR; Xiang, Z1
Corcoba, A; Cuenod, M; Do, KQ; Duarte, JM; Gruetter, R; Monin, A; Steullet, P; Van de Looij, Y1
Huang, XF; Kapsa, RM; Stewart, EM; Wallace, GG; Wu, Z1
Brandon, NJ; Hinchliffe, RM; Huszar, SL; Hutson, PH; Jacobson, MA; Jones, B; Kandebo, M; McNaughton, CH; Mullins, CM; Pascarella, DM; Sachs, N; Smith, SM; Sparey, T; Surles, NO; Uslaner, JM; Venkatraman, S; Yao, L; Young, MB1
Williams, M1
Boers, GH; The, GK; van de Kerkhof, R; van der Meer, JW1
Abeywickrema, P; Almond, S; Brandon, N; Byrne, N; Campbell, A; Hutson, PH; Jacobson, M; Jones, B; Munshi, S; Pascarella, D; Pike, A; Prasad, GS; Sachs, N; Sakatis, M; Sardana, V; Sparey, T; Venkatraman, S; Young, MB1
Dimitri, E; Landry, P; Légaré, N; Tessier, S1
Kaufman, J; Renz, RH; Smith, S; Sohler, A1
Gorchein, A1
Bristow, LJ; Kramer, MS; Kulagowski, J; Patel, S; Ragan, CI; Seabrook, GR1
Chari, S; Deth, RC; DuRand, CJ; Kotb, M; Kramer, ML; Liu, D; Nagata, M; Ouellette, D; Sharma, A; Shim, S; Tan, W; Wick, PF1
Gorchein, A; Rogers, AT1
Duhan, HA; Gendler, PL; Rapoport, H1
Cruz, R; Vogel, WH1
Irvine, DG1
Ellman, GL; Jacobson, SJ; Rapoport, H1
Sohler, A1
Heleniak, EP; Lamola, SW1
Ban, TA1
Durkó, I; Huszák, I; Karsai, K1
Krischer, K; Pfeiffer, CC1
Grant, FW1

Reviews

2 review(s) available for pyrroles and Schizophrenia

ArticleYear
Pyroluria: Fact or Fiction?
    Journal of alternative and complementary medicine (New York, N.Y.), 2021, Volume: 27, Issue:5

    Topics: Adult; Child; Female; Humans; Male; Porphyrias; Pyrroles; Schizophrenia; Vitamin B 6; Vitamin B 6 Deficiency; Zinc

2021
Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist.
    Trends in pharmacological sciences, 1997, Volume: 18, Issue:6

    Topics: Animals; Antipsychotic Agents; Biological Availability; Clinical Trials as Topic; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Pyridines; Pyrroles; Receptors, Dopamine D4; Rodentia; Schizophrenia

1997

Trials

3 trial(s) available for pyrroles and Schizophrenia

ArticleYear
The H3 antagonist ABT-288 is tolerated at significantly higher exposures in subjects with schizophrenia than in healthy volunteers.
    British journal of clinical pharmacology, 2014, Volume: 77, Issue:6

    Topics: Adult; Area Under Curve; Double-Blind Method; Female; Histamine H3 Antagonists; Humans; Male; Middle Aged; Pyridazines; Pyrroles; Schizophrenia

2014
A randomized trial of the efficacy and safety of the H3 antagonist ABT-288 in cognitive impairment associated with schizophrenia.
    Schizophrenia bulletin, 2014, Volume: 40, Issue:6

    Topics: Adult; Cognition Disorders; Double-Blind Method; Female; Histamine H3 Antagonists; Humans; Male; Middle Aged; Pyridazines; Pyrroles; Schizophrenia; Treatment Failure

2014
Negative findings with nicotinic acid in the treatment of schizophrenias.
    International pharmacopsychiatry, 1974, Volume: 9, Issue:3

    Topics: Adrenochrome; Bufotenin; Dimethoxyphenylethylamine; Drug Therapy, Combination; Female; Humans; Male; Methionine; Methylation; Nicotinic Acids; Placebos; Pyridoxine; Pyrroles; Schizophrenia

1974

Other Studies

24 other study(ies) available for pyrroles and Schizophrenia

ArticleYear
Alpha 7 nicotinic receptor agonist and positive allosteric modulators improved social and molecular deficits of MK-801 model of schizophrenia in rats.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 193

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Avoidance Learning; Clozapine; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Dizocilpine Maleate; Glycogen Synthase Kinase 3 beta; Isoxazoles; Male; Phenylurea Compounds; Prefrontal Cortex; Proto-Oncogene Proteins c-akt; Pyridazines; Pyrroles; Rats; Rats, Wistar; Schizophrenia; Signal Transduction; Social Interaction; Treatment Outcome

2020
α7 nicotinic receptor agonist and positive allosteric modulators differently improved schizophrenia-like cognitive deficits in male rats.
    Behavioural brain research, 2021, 01-15, Volume: 397

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Behavior, Animal; Cognitive Dysfunction; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Isoxazoles; Male; Nicotinic Agonists; Phenylurea Compounds; Pyridazines; Pyrroles; Rats; Rats, Wistar; Recognition, Psychology; Schizophrenia

2021
Dopamine D
    Journal of psychopharmacology (Oxford, England), 2017, Volume: 31, Issue:4

    Topics: Animals; Antipsychotic Agents; Benzamides; Clozapine; Cognitive Dysfunction; Female; Lurasidone Hydrochloride; Phencyclidine; Piperazines; Pyridines; Pyrroles; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D4; Schizophrenia; Serotonin 5-HT1 Receptor Agonists

2017
Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, Volume: 41, Issue:2

    Topics: Animals; Antipsychotic Agents; Cognition; Disease Models, Animal; Long-Term Synaptic Depression; Male; Mice, Inbred C57BL; Mice, Knockout; Patch-Clamp Techniques; Phencyclidine; Pyridines; Pyrroles; Receptor, Muscarinic M1; Schizophrenia; Schizophrenic Psychology; Social Behavior

2016
Glutathione Deficit Affects the Integrity and Function of the Fimbria/Fornix and Anterior Commissure in Mice: Relevance for Schizophrenia.
    The international journal of neuropsychopharmacology, 2015, Oct-03, Volume: 19, Issue:3

    Topics: Animals; Brain; Diffusion Tensor Imaging; Disease Models, Animal; Glutamate-Cysteine Ligase; Glutathione; Male; Mice, Knockout; Organ Size; Pyrroles; Schizophrenia; Tissue Culture Techniques; White Matter

2015
Use of conducting polymers to facilitate neurite branching in schizophrenia-related neuronal development.
    Biomaterials science, 2016, Jul-19, Volume: 4, Issue:8

    Topics: Cell Line; Gene Knockout Techniques; Humans; Neuregulin-1; Neurons; Polymers; Pyrroles; Schizophrenia; Tissue Scaffolds

2016
The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 328, Issue:3

    Topics: Aged; Animals; D-Amino-Acid Oxidase; Dizocilpine Maleate; Habituation, Psychophysiologic; Humans; Male; Models, Molecular; Pyrroles; Rats; Rats, Wistar; Recognition, Psychology; Schizophrenia; Serine; Thiophenes

2009
Commentary: genome-based CNS drug discovery: D-amino acid oxidase (DAAO) as a novel target for antipsychotic medications: progress and challenges.
    Biochemical pharmacology, 2009, Dec-01, Volume: 78, Issue:11

    Topics: Animals; Antipsychotic Agents; D-Amino-Acid Oxidase; Enzyme Activators; Genome, Human; Humans; Isoxazoles; Pyrazoles; Pyrroles; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Thiophenes

2009
[Hemopyrrollactamuria (HPU); from spots to pseudo-disease].
    Nederlands tijdschrift voor geneeskunde, 2003, Sep-06, Volume: 147, Issue:36

    Topics: Humans; Metabolic Diseases; Porphyrias; Pyrroles; Schizophrenia

2003
The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors.
    Bioorganic & medicinal chemistry letters, 2008, Jun-01, Volume: 18, Issue:11

    Topics: Animals; Carboxylic Acids; Combinatorial Chemistry Techniques; Crystallography, X-Ray; D-Amino-Acid Oxidase; Enzyme Inhibitors; Molecular Conformation; Molecular Structure; Pyrroles; Rats; Schizophrenia; Serine

2008
Efficacy of lipid-lowering medications in patients treated with clozapine: a naturalistic study.
    Journal of clinical psychopharmacology, 2008, Volume: 28, Issue:3

    Topics: Adult; Antipsychotic Agents; Atorvastatin; Cholesterol; Clozapine; Female; Fenofibrate; Gemfibrozil; Heptanoic Acids; Humans; Hyperlipidemias; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Pravastatin; Psychotic Disorders; Pyrroles; Retrospective Studies; Schizophrenia; Treatment Outcome; Triglycerides

2008
Significance of hydroxyskatole and mauve factor excretion in schizophrenia.
    International journal of neuropsychiatry, 1967, Volume: 3, Issue:4

    Topics: Adult; Alcoholism; Chromatography, Thin Layer; Chronic Disease; Epilepsy; Furans; Humans; Indoles; Male; Middle Aged; Pyrroles; Schizophrenia

1967
Urine concentration of 3-ethyl-5-hydroxy-4,5-dimethyl-delta 3-pyrrolin-2-one ('mauve factor') is not causally related to schizophrenia or to acute intermittent porphyria.
    Clinical science (London, England : 1979), 1980, Volume: 58, Issue:6

    Topics: Acute Disease; Adult; Chromatography, Gas; Female; Humans; Porphyrias; Pyrroles; Schizophrenia

1980
D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia.
    Molecular psychiatry, 1999, Volume: 4, Issue:3

    Topics: Amino Acid Sequence; Aminopyridines; Animals; Benzazepines; Binding Sites; Carbon Radioisotopes; CHO Cells; Clozapine; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Formates; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Methionine; Mutagenesis, Site-Directed; Neuroblastoma; Phospholipids; Phosphorylation; Piperidines; Psychotic Disorders; Pyridines; Pyrroles; Raclopride; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; S-Adenosylmethionine; Salicylamides; Schizophrenia; Transfection; Tumor Cells, Cultured

1999
The 'mauve factor' of schizophrenia and porphyria, 5-hydroxyhaemopyrrole lactam, has low pharmacological potency on guinea-pig ileum.
    Experientia, 1979, Aug-15, Volume: 35, Issue:8

    Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Humans; Ileum; Muscle Contraction; Porphyrias; Pyrroles; Rats; Schizophrenia

1979
Hemopyrrole and kryptopyrrole are absent from the urine of schizophrenics and normal persons.
    Clinical chemistry, 1978, Volume: 24, Issue:2

    Topics: Chromatography, Gas; Humans; Mass Spectrometry; Methods; Porphyrias; Pyrroles; Schizophrenia

1978
Pyroluria: a poor marker in chronic schizophrenia.
    The American journal of psychiatry, 1978, Volume: 135, Issue:10

    Topics: Adult; Chronic Disease; Female; Humans; Male; Middle Aged; Pyrroles; Schizophrenia; Vitamin B 6 Deficiency; Zinc

1978
Hydroxy-hemopyrrolenone, not kryptopyrrole, in the urine of schizophrenics and porphyrics.
    Clinical chemistry, 1978, Volume: 24, Issue:11

    Topics: Humans; Isomerism; Porphyrias; Pyrroles; Schizophrenia

1978
The nonoccurrence of hemo- and kryptopyrrole in urine of schizophrenics.
    Biological psychiatry, 1975, Volume: 10, Issue:1

    Topics: Chromatography, Gas; Humans; Mass Spectrometry; Pyrroles; Schizophrenia

1975
Letter: Urinary kryptopyrrole.
    Biological psychiatry, 1975, Volume: 10, Issue:6

    Topics: Humans; Pyrroles; Schizophrenia

1975
A new prostaglandin disturbance syndrome in schizophrenia: delta-6-pyroluria.
    Medical hypotheses, 1986, Volume: 19, Issue:4

    Topics: Alprostadil; Aspartate Aminotransferases; Fatty Acid Desaturases; Fatty Acids, Essential; Humans; Insulin; Linoleic Acid; Linoleic Acids; Linoleoyl-CoA Desaturase; Mutation; Prostaglandins; Pyrroles; Schizophrenia; Syndrome

1986
Experimental data to the pathogenesis of cryptopyrrole excretion in schizophrenia, I.
    Acta physiologica Academiae Scientiarum Hungaricae, 1972, Volume: 42, Issue:1

    Topics: Chromatography; Depression; Epilepsy; Humans; Mass Screening; Paranoid Disorders; Periodicity; Porphyrins; Psychotic Disorders; Pyrroles; Schizophrenia; Tryptophan

1972
Biochemical relationship between kryptopyrrole (mauve factor and trans-3-methyl-2-hexenoic acid (schizophrenia odor).
    Research communications in chemical pathology and pharmacology, 1973, Volume: 5, Issue:1

    Topics: Caproates; Carboxylic Acids; Decarboxylation; Humans; Pyrroles; Schizophrenia

1973
Comments on a proposed mechanism of formation of the "schizophrenic odor factor".
    Research communications in chemical pathology and pharmacology, 1973, Volume: 6, Issue:1

    Topics: Amines; Biotransformation; Caproates; Deamination; Fatty Acids, Unsaturated; Humans; Odorants; Pyrroles; Schizophrenia; Sweat; Transaminases; Vinyl Compounds

1973