Page last updated: 2024-08-18

pyrroles and Nervous System Diseases

pyrroles has been researched along with Nervous System Diseases in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19904 (28.57)18.7374
1990's3 (21.43)18.2507
2000's2 (14.29)29.6817
2010's4 (28.57)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Abdolghaffari, AH; Arab, ZN; Dehpour, AR; Jafari, RM; Khayatan, D; Momtaz, S; Razavi, SM; Zare, K1
Beijnen, JH; Cirkel, GA; de Jonge, MJ; Gadellaa-van Hooijdonk, CG; Haanen, JB; Huitema, AD; Kloth, JS; Lankheet, NA; Lolkema, MP; Mathijssen, RH; Schellens, JH; Sleijfer, S; Steeghs, N; Voest, EE1
Cardona-Gómez, GP; Garcia-Segura, LM; Gutierrez-Vargas, JA; Muñoz-Manco, JI1
Ashida, K; Hibberd, M; Jenkins, H; Jenkins, R; Nishimura, A; Ogama, Y; Okamoto, H; Sakurai, Y; Warrington, S; Yoneyama, T1
Hillyer, J; Kwon, BK; Lee, JH; Mann, CM; Stammers, AM; Tetzlaff, W1
Anthony, DC; Boekelheide, K; Graham, DG; Maschmann, NA; Richards, RG; Shaw, BR; Wolfram, JW1
DeCaprio, AP; Olajos, EJ; Weber, P1
Csanády, GA; Dietz, W; Filser, JG; Kessler, W; Kreuzer, PE; Richter, M; Störmer, A1
Lawson, K1
Kim, PJ; Markesbery, WR; Montine, KS; Montine, TJ; Olson, SJ1
Batoréu, MC; dos Santos, AP; Mateus, ML1
Bonetta, L1
Irvine, DG1
Autilio-Gambetti, L; Gambetti, P; Sayre, LM1

Reviews

3 review(s) available for pyrroles and Nervous System Diseases

ArticleYear
Licofelone, a potent COX/5-LOX inhibitor and a novel option for treatment of neurological disorders.
    Prostaglandins & other lipid mediators, 2021, Volume: 157

    Topics: Cyclooxygenase 2; Cyclooxygenase Inhibitors; Humans; Lipoxygenase Inhibitors; Nervous System Diseases; Pyrroles

2021
Potassium channel activation: a potential therapeutic approach?
    Pharmacology & therapeutics, 1996, Volume: 70, Issue:1

    Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Benzopyrans; Bronchodilator Agents; Calcium; Cardiovascular Diseases; Cromakalim; Hair; Humans; Intraocular Pressure; Muscle, Skeletal; Nervous System Diseases; Parasympatholytics; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Reproduction; Respiratory Tract Diseases; Synaptic Transmission; Urologic Diseases; Vasodilator Agents

1996
Pathogenesis of experimental giant neurofilamentous axonopathies: a unified hypothesis based on chemical modification of neurofilaments.
    Brain research, 1985, Volume: 357, Issue:1

    Topics: Animals; Axonal Transport; Axons; Chickens; Cytoskeleton; Disease Models, Animal; Glyceraldehyde-3-Phosphate Dehydrogenases; Hexanones; Humans; In Vitro Techniques; Intermediate Filament Proteins; Intermediate Filaments; Mice; Nervous System Diseases; Neurofilament Proteins; Nitriles; Phosphorylation; Pyrroles; Rats

1985

Trials

3 trial(s) available for pyrroles and Nervous System Diseases

ArticleYear
Pharmacokinetically guided sunitinib dosing: a feasibility study in patients with advanced solid tumours.
    British journal of cancer, 2014, May-13, Volume: 110, Issue:10

    Topics: Adult; Aged; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Fatigue; Feasibility Studies; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Indoles; Male; Middle Aged; Neoplasms; Nervous System Diseases; Pilot Projects; Protein Kinase Inhibitors; Pyrroles; Salvage Therapy; Sunitinib

2014
Randomised clinical trial: safety, tolerability, pharmacokinetics and pharmacodynamics of repeated doses of TAK-438 (vonoprazan), a novel potassium-competitive acid blocker, in healthy male subjects.
    Alimentary pharmacology & therapeutics, 2015, Volume: 41, Issue:7

    Topics: Adult; Asian People; Dose-Response Relationship, Drug; Double-Blind Method; Gastric Acid; Gastrointestinal Agents; Half-Life; Humans; Japan; Male; Metabolic Clearance Rate; Middle Aged; Nervous System Diseases; Potassium; Pyrroles; Sulfonamides; United Kingdom; White People; Young Adult

2015
Comparative estimation of the neurotoxic risks of N-hexane and N-heptane in rats and humans based on the formation of the metabolites 2,5-hexanedione and 2,5-heptanedione.
    Advances in experimental medicine and biology, 1996, Volume: 387

    Topics: Administration, Inhalation; Adult; Animals; Body Burden; Cross-Linking Reagents; Half-Life; Heptanes; Hexanes; Hexanones; Humans; Ketones; Male; Nervous System Diseases; Pyrroles; Rats; Rats, Wistar; Risk Assessment

1996

Other Studies

8 other study(ies) available for pyrroles and Nervous System Diseases

ArticleYear
GluN2B N-methyl-D-aspartic acid receptor subunit mediates atorvastatin-Induced neuroprotection after focal cerebral ischemia.
    Journal of neuroscience research, 2014, Volume: 92, Issue:11

    Topics: Animals; Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Embryo, Mammalian; Heptanoic Acids; Male; Maze Learning; Nerve Tissue Proteins; Nervous System Diseases; Piperidines; Platelet Aggregation Inhibitors; Pyrroles; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recovery of Function; Somatosensory Cortex; Time Factors

2014
Lack of robust neurologic benefits with simvastatin or atorvastatin treatment after acute thoracic spinal cord contusion injury.
    Experimental neurology, 2010, Volume: 221, Issue:2

    Topics: Analysis of Variance; Animals; Atorvastatin; Benzenesulfonates; Dietary Sucrose; Disease Models, Animal; Drug Administration Routes; Ectodysplasins; Exploratory Behavior; Food, Formulated; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Motor Activity; Nervous System Diseases; Pain Measurement; Pain Threshold; Psychomotor Performance; Pyrroles; Rats; Rats, Sprague-Dawley; Sacrococcygeal Region; Simvastatin; Spinal Cord Injuries

2010
Studies of the molecular pathogenesis of hexane neuropathy. II. Evidence that pyrrole derivatization of lysyl residues leads to protein crosslinking.
    Toxicology and applied pharmacology, 1982, Volume: 64, Issue:3

    Topics: Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Hexanes; Hexanones; Lysine; Nervous System Diseases; Pyrroles

1982
Covalent binding of a neurotoxic n-hexane metabolite: conversion of primary amines to substituted pyrrole adducts by 2,5-hexanedione.
    Toxicology and applied pharmacology, 1982, Sep-30, Volume: 65, Issue:3

    Topics: Amines; Amino Acids; Animals; Chemical Phenomena; Chemistry; Chickens; Chromogenic Compounds; Female; Hexanes; Hexanones; Ketones; Nervous System Diseases; Proteins; Pyrroles

1982
4-hydroxy-2-nonenal pyrrole adducts in human neurodegenerative disease.
    Journal of neuropathology and experimental neurology, 1997, Volume: 56, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Aldehydes; Alzheimer Disease; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Brain; DNA Adducts; Female; Genotype; Homozygote; Humans; Male; Middle Aged; Nerve Degeneration; Nervous System Diseases; Pyrroles

1997
Interaction of zinc on biomarker responses in rats exposed to 2,5-hexanedione by two routes of exposure.
    Toxicology letters, 2001, Feb-03, Volume: 119, Issue:1

    Topics: Administration, Oral; Animals; Biomarkers; Dose-Response Relationship, Drug; Drug Interactions; Hexanones; Injections, Intraperitoneal; Male; Nervous System Diseases; Neurotoxins; Pyrroles; Rats; Rats, Wistar; Zinc Acetate

2001
Potential neurological value of statins increases.
    Nature medicine, 2002, Volume: 8, Issue:6

    Topics: Alzheimer Disease; Anticholesteremic Agents; Atorvastatin; Costs and Cost Analysis; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Nervous System Diseases; Pyrroles; United States

2002
Pyrroles in neuropsychiatric and porphyric disorders: confirmation of a metabolite structure by synthesis.
    Life sciences, 1978, Sep-04, Volume: 23, Issue:9

    Topics: Chromatography, Gel; Humans; Mental Disorders; Nervous System Diseases; Porphyrias; Pyrroles

1978