Compounds > pyrroles
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pyrroles and Muscle Relaxation

pyrroles has been researched along with Muscle Relaxation in 148 studies

Research

Studies (148)

TimeframeStudies, this research(%)All Research%
pre-199016 (10.81)18.7374
1990's121 (81.76)18.2507
2000's8 (5.41)29.6817
2010's3 (2.03)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cai, C; Lei, J; Liu, QH; Shen, J; Tan, H; Xue, L1
Dudek, M; Filipek, B; Kazek, G; Kubacka, M; Malinka, W; Mogilski, S; Redzicka, A1
Cai, CY; Cai, ZX; Gu, XY; Guo, HS; Qi, QH; Shan, LJ; Wang, YX; Yin, XZ1
Drevenšek, G; Janić, M; Lunder, M; Šabovič, M; Žiberna, L1
De Godoy, M; Li, F; Rattan, S1
Buckner, SA; Daza, AV; Gopalakrishnan, M; Malysz, J; Milicic, I; Perez-Medrano, A1
Bourreau, JP; Chan, FL; Chan, YC; He, GW; Huang, Y; Lau, CW; Yao, XQ1
Cook, JM; Griebel, G; Licata, SC; Platt, DM; Rowlett, JK; Sarma, PV1
Shah, DI; Singh, M1
Abou-Gharbia, M; Freed, ME; McCaully, RJ; Silver, PJ; Wendt, RL1
Shikada, K; Tanaka, S3
Asano, M; Fujikura, T; Masuda, N; Matsumoto, Y; Shibasaki, K; Shirai, Y; Taguchi, T; Takenaka, T; Tsuzuki, R; Uchida, W1
Calder, JA; Schachter, M; Sever, PS1
Brock, GB; Lue, TF; Nunes, L; Riemer, RK; Tanagho, EA; von Heyden, B1
Kobayashi, D; Okabe, E; Ozono, S; Todoki, K1
Bevan, JA; Wellman, GC1
Calderaro, V; Costantino, M; D'Agostino, B; Mangrella, M; Matera, MG; Rossi, F1
Dave, KC; Goyal, RK; Mehta, AA1
Kageyama, M; Taira, N; Yanagisawa, T1
Högestätt, ED; Waldeck, K; Zygmunt, PM1
Kam, KL; Pfaffendorf, M; van Zwieten, PA1
Atwal, KS; D'Alonzo, AJ; Grover, GJ; McCullough, JR; Sargent, CA1
Satake, N; Shibata, S; Zhou, Q1
Mellemkjaer, S; Nielsen-Kudsk, JE1
Cai, B; deBoisblanc, B; Gillott, D; Goharderakhshan, R; Greenberg, SS; Hao, Q; Hyman, A; Lippton, H; Summer, WR1
Do, ML; Halterman, TJ; Howe, BB; Kau, ST; Li, JH; McConville, MW; Trivedi, S; Yochim, CL; Zografos, P1
Grundemar, L; Högestätt, ED; Zygmunt, PM1
Imagawa, J; Kamei, K; Kuriyama, H; Nabata, H; Yoshida, S1
Masuda, Y; Tanaka, S; Yamashita, T1
Atwal, KS1
Hou, YS; Lee, SS; Teng, CM; Yu, SM1
Buchanan, LV; Cimini, MG; Gibson, JK; Khan, SA; Meisheri, KD; Norman, NR; Shebuski, RJ; Toombs, CF1
Aloamaka, CP; Ebeigbe, AB; Ighoroje, AD; Oguogho, A1
Fukushima, H; Izawa, T; Kashiwabara, T; Ogawa, N1
Han, C; Xia, Y1
Coleman, HA; Parkington, HC; Tare, M; Tonta, MA1
Fukata, Y; Fukushima, H; Harada, K; Kasai, H; Ogawa, N1
Fukata, Y; Fukushima, H; Jinno, Y; Kaneta, S; Kasai, H; Ogawa, N1
Fukata, Y; Fukushima, H; Jinno, Y; Kaneta, S; Ogawa, N; Okada, Y; Yokoyama, T1
Imagawa, J; Kamei, K; Koga, T; Nabata, H; Yoshida, S1
Croxton, TL; Fernandes, LB; Hirshman, CA; Lindeman, KS1
Buckle, DR1
Nielsen-Kudsk, JE; Thirstrup, S3
Aubier, M; Brione, E; De Vernejoul, D; Pavlovic, D1
MacDonald, E; McDonald, A; Scott, PJ; Wadsworth, RM1
Falotico, R; Giardino, EC; Katz, LB; Moore, JB; Salata, JJ1
Quast, U1
Mombouli, JV; Nakashima, M; Taylor, AA; Vanhoutte, PM1
Fukushima, H; Jinno, Y; Kaneta, S; Kasai, H; Miwa, A; Motoki, K; Ogawa, N; Okada, Y1
Alouan, LA; Armour, CL; Black, JL; Johnson, PR; Marthan, R; McKay, KO; Savineau, JP; Tunon de Lara, JM; Villanove, X1
Ko, FN; Lin, CH; Lu, ST; Teng, CM; Wu, YC1
Greenwood, IA; Weston, AH1
Barnes, PJ; Belvisi, MG; Miura, M; Tadjkarimi, S; Ward, JK; Yacoub, MH1
Arch, JR; Bowring, NE; Buckle, DR; Foster, KA; Shaw, DJ; Taylor, JF; Taylor, SG1
Bellan, JA; Kadowitz, PJ; Longenecker, LL; McNamara, DB1
Halaka, NN; Lodge, NJ1
Liu, J; Luo, Y; Zhou, L1
Kato, Y; Matsuda, T; Okazaki, K; Shigenobu, K; Tanaka, H1
Bonasso, CL; Lewis, AI; Rapoport, RM; Sperelakis, N; Zuccarello, M1
Andersson, KE; Persson, K; Waldeck, K1
Davis, SC; Edwards, G; Högestätt, ED; Weston, AH; Zygmunt, PM1
Advenier, C; Bakdach, H; Bonnet, PA; Cui, YY; Michel, A; Naline, E1
Berto, L; Bonnet, PA; Cortijo, J; Michel, A; Morcillo, EJ; Navarrete, C; Sanz, C; Villagrasa, V1
Satake, N; Shibata, M; Shibata, S1
Izawa, T; Izumi, H; Kawahara, J; Okada, Y1
Calixto, JB; Cechinel-Filho, V; Paulino, N; Yunes, RA1
Angus, JA; Fujiwara, T1
Hüsken, BC; Pfaffendorf, M; Timmenga, EJ; Van Zwieten, PA; Vroom, MB1
Mellemkjaer, S; Nielsen-Kudsk, JE; Thirstrup, S1
McPherson, GA; Piekarska, AE1
Anthony, DM; Buckett, WR; Dickinson, K; Jones, RB; Kaul, CL; Marita, AR1
Huang, Y; Kwok, KH1
Dahl, R; Nielsen-Kudsk, F; Thirstrup, S1
Kinoshita, M; Liu, Q; Matsumoto, T; Nakae, I; Omura, T; Takahashi, M; Takaoka, A1
Van de Voorde, J; Vanheel, B1
Hosoki, K; Karasawa, T; Nagata, S; Takeyama, K1
Akar, F; Aşlamaci, S; Kanzik, I; Köksoy, C; Tufan, H; Uydeş-Dogan, BS1
Li, L; Paakkari, I; Vaali, K; Vapaatalo, H1
Chapple, CR; Chess-Williams, R; Korstanje, C; Martin, SW; Radley, SC1
Allescher, HD; Franck, H; Huber, A; Ruth, P; Schusdziarra, V; Storr, M; Trudrung, P1
Adaikan, PG; Hayes, ES; Ng, SC; Ratnam, SS1
Dick, JM; Lefebvre, RA1
Allescher, HD; Folmer, R; Kurjak, M; Schusdziarra, V; Storr, M1
Kamata, K; Kasuya, Y; Miyata, N; Otomo, S; Tsuchida, K; Yamaura, H1
Downing, SJ; Hollingsworth, M1
Braida, C; Holzmann, S; Kukovetz, WR; Pöch, G1
Berry, JL; Foster, RW; Small, RC2
Illiano, S; Nagao, T; Vanhoutte, PM1
Asano, M; Ito, K; Kanno, T; Masuzawa-Ito, K; Ohashi, H; Suzuki, H; Suzuki, K; Takewaki, T1
Huang, TF; Ko, FN; Su, MJ; Teng, CM; Wang, ML; Wu, TS; Yu, SM1
Barnes, PJ; Belvisi, MG; Miura, M; Stretton, CD; Yacoub, MH1
Deitmer, P; Golenhofen, K; Noack, T1
Berry, JL; Edwards, G; Hollingsworth, M; Hughes, SJ; Miller, AJ; Small, RC; Smith, RD; Weston, AH1
Armstrong, JM; Barras, M; Hicks, PE; Lawson, K; Martin, DJ; Zazzi-Sudriez, E1
Cortijo, J; Morcillo, E; Paris, F; Pedrós, C; Perpiñá, M; Sarriá, B1
Arch, JR; Foster, KA; Newson, PN; Shaw, D; Taylor, SG1
Fernandes, LB; Goldie, RG; Hay, DW; Muccitelli, RM; Page, CP; Preuss, JM; Spina, D1
Eckman, DM; Frankovich, JD; Keef, KD1
Kreye, VA; Pfründer, D; Theiss, U1
Bray, K; Quast, U1
Horacek, J; Lefebvre, RA1
Albus, U; Englert, HC; Fürst, U; Gehring, D; Rosenkranz, B; Schölkens, BA; Scholz, W; Wirth, K1
Bang, L; Nielsen-Kudsk, JE1
Berry, JL; Burka, JF; Foster, RW; Small, RC; Watt, AJ1
Berry, JL; Elliott, KR; Foster, RW; Green, KA; Murray, MA; Small, RC1
Fukushima, H; Izawa, T; Kashiwabara, T; Nakajima, S; Nishikori, K1
Armstrong, SJ; Grimes, D; Rimele, TJ; Sturm, RJ1
Charette, L; Garcia, ML; Jones, TR; Kaczorowski, GJ1
Longmore, J; Newgreen, DT; Weston, AH1
Berry, JL; Cook, SJ; Foster, RW; Green, KA; Murray, MA; Small, RC1
Corrêa, DS; Rabetti, AC; Rae, GA1
Cohen, RA; Cowan, CL1
de Moura, RS; Jasbik, W1
Arch, JR; Bowring, NE; Buckle, DR; Clarke, GD; Taylor, JF1
Shikada, K; Tanaka, S; Yamamoto, A1
Arakawa, C; Kasuya, Y; Masuda, Y; Miyajima, M; Shigenobu, K; Tanaka, S; Yamashita, T1
Arch, JR; Buckle, DR; Carey, C; Faller, A; Foster, KA; Houge-Frydrych, CS; Parr-Dobrzanski, H; Pinto, IL; Smith, DG; Taylor, SG1
Brown, TJ; Raeburn, D1
Angus, JA; Keily, SG; McPherson, GA1
Arch, JR; Buckle, DR; Edge, C; Foster, KA; Houge-Frydrych, CS; Pinto, IL; Smith, DG; Taylor, JF; Taylor, SG; Tedder, JM1
Bang, L; Brønsgaard, AM; Nielsen-Kudsk, JE1
Asano, M; Masuzawa, K; Matsuda, T1
Antoine, MH; Berkenboom, G; Fang, ZY; Fontaine, J; Herchuelz, A; Hermann, M; Lebrun, P1
Taira, N; Teshigawara, T; Yanagisawa, T1
Arch, JR; Buckle, DR; Fenwick, AE; Houge-Frydrych, CS; Pinto, IL; Smith, DG; Taylor, SG; Tedder, JM1
Cox, RH1
Andersson, KE; Fovaeus, M; Hedlund, H; Holmquist, F1
Cowlrick, IS; Paciorek, PM; Perkins, RS; Taylor, JC; Waterfall, JF; Wilkinson, GF1
Allen, SL; Boyle, JP; Cortijo, J; Foster, RW; Morgan, GP; Small, RC1
Buckingham, RE; Hamilton, TC; Howlett, DR; Mootoo, S; Wilson, C1
Boyle, JP; Murray, MA; Small, RC1
Bray, KM; Duty, S; Weston, AH1
Eltze, M1
Kamata, K; Kasuya, Y; Miyata, N1
Dale, MM; Obianime, AW1
Angus, JA; McPherson, GA1
Cain, CR; Nicholson, CD1
De Jonckheere, B; McCaig, DJ1
Gillespie, JS; Sheng, H1
Coldwell, MC; Cooper, SM; Hamilton, TC; Howlett, DR; Wilson, C1
Cheung, WM; Falotico, R; Haertlein, B; Keiser, J; Tobia, A1
Kitamura, K; Kuriyama, H; Nakao, K; Okabe, K; Weston, AH1
Akbarali, HI; Bieger, D; Ohia, SE; Triggle, CR1

Reviews

4 review(s) available for pyrroles and Muscle Relaxation

ArticleYear
Pharmacology and structure-activity relationships for KATP modulators: tissue-selective KATP openers.
    Journal of cardiovascular pharmacology, 1994, Volume: 24 Suppl 4

    Topics: Action Potentials; Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cardiovascular Diseases; Cromakalim; Diazoxide; Guanidines; Guinea Pigs; Minoxidil; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Radioligand Assay; Rats; Structure-Activity Relationship; Vasodilator Agents

1994
Prospects for potassium channel activators in the treatment of airways obstruction.
    Pulmonary pharmacology, 1993, Volume: 6, Issue:3

    Topics: Airway Obstruction; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Humans; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Trachea

1993
Do the K+ channel openers relax smooth muscle by opening K+ channels?
    Trends in pharmacological sciences, 1993, Volume: 14, Issue:9

    Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Humans; Inositol 1,4,5-Trisphosphate; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium; Potassium Channels; Pyrroles; Vasodilator Agents

1993
Potassium channel opening drugs and the airways.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1992, Volume: 25, Issue:10

    Topics: Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; In Vitro Techniques; Ion Channel Gating; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles

1992

Other Studies

144 other study(ies) available for pyrroles and Muscle Relaxation

ArticleYear
Relaxing Effect of TSU-68, an Antiangiogenic Agent, on Mouse Airway Smooth Muscle.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 41, Issue:6

    Topics: Acetylcholine; Angiogenesis Inhibitors; Animals; Calcium; Calcium Channels; Cells, Cultured; Indoles; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle Relaxation; Myocytes, Smooth Muscle; Oxindoles; Patch-Clamp Techniques; Potassium; Propionates; Pyrroles

2017
Antinociceptive, anti-inflammatory and smooth muscle relaxant activities of the pyrrolo[3,4-d]pyridazinone derivatives: Possible mechanisms of action.
    Pharmacology, biochemistry, and behavior, 2015, Volume: 133

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Guinea Pigs; Histamine H1 Antagonists; Male; Mice; Molecular Structure; Muscle Relaxation; Muscle, Smooth; Pain Measurement; Pyridazines; Pyrroles; Rats; Rotarod Performance Test

2015
Dendroaspis natriuretic peptide relaxes gastric antral circular smooth muscle of guinea-pig through the cGMP/cGMP-dependent protein kinase pathway.
    World journal of gastroenterology, 2008, Sep-21, Volume: 14, Issue:35

    Topics: Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Elapid Venoms; Female; Guinea Pigs; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Male; Muscle Relaxation; Muscle, Smooth; Patch-Clamp Techniques; Peptides; Potassium Channels, Calcium-Activated; Protein Kinase Inhibitors; Pyloric Antrum; Pyrroles; Signal Transduction

2008
A low-dose atorvastatin and losartan combination directly improves aortic ring relaxation and diminishes ischaemic-reperfusion injury in isolated rat hearts.
    Medical science monitor : international medical journal of experimental and clinical research, 2012, Volume: 18, Issue:9

    Topics: Analysis of Variance; Animals; Aorta; Atorvastatin; Coronary Vessels; Dose-Response Relationship, Drug; Drug Therapy, Combination; Heptanoic Acids; Losartan; Male; Muscle Relaxation; Pyrroles; Rats; Rats, Wistar; Regional Blood Flow; Reperfusion Injury; Treatment Outcome

2012
Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:3

    Topics: Adenine; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blotting, Western; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; GTP-Binding Proteins; Guanylate Cyclase; Indoles; Male; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Procaterol; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3; Suramin; Xamoterol

2004
Functional characterization of large conductance calcium-activated K+ channel openers in bladder and vascular smooth muscle.
    Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 369, Issue:5

    Topics: Animals; Benzimidazoles; Electric Stimulation; Guinea Pigs; Indoles; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Potassium Channels, Calcium-Activated; Pyrroles; Rats; Urinary Bladder

2004
The relaxant effect of urocortin in rat pulmonary arteries.
    Regulatory peptides, 2004, Sep-15, Volume: 121, Issue:1-3

    Topics: Animals; Barium Compounds; Carbazoles; Chlorides; Corticotropin-Releasing Hormone; Endothelium; Indoles; Muscle Relaxation; Nitric Oxide; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Pulmonary Artery; Pyrroles; Rats; Urocortins

2004
Contribution of GABAA receptor subtypes to the anxiolytic-like, motor, and discriminative stimulus effects of benzodiazepines: studies with the functionally selective ligand SL651498 [6-fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Conflict, Psychological; Discrimination Learning; Dose-Response Relationship, Drug; Female; Indoles; Macaca mulatta; Male; Muscle Relaxation; Pyrroles; Receptors, GABA-A; Saimiri

2005
Effect of demethylasterriquinone b1 in hypertension associated vascular endothelial dysfunction.
    International journal of cardiology, 2007, Sep-03, Volume: 120, Issue:3

    Topics: Animals; Aorta, Thoracic; Atorvastatin; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Indoles; Male; Microscopy, Electron; Muscle Relaxation; Muscle, Smooth, Vascular; NADPH Oxidases; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Pyrroles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxides; Thiobarbituric Acid Reactive Substances

2007
Tetrahydropyrrolo[1,2-a]quinoxalines and tetrahydropyrrolo[1,2-a]pyrido[3,2-a]pyrazines: vascular smooth muscle relaxants and antihypertensive agents.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Chemical Phenomena; Chemistry; Female; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Muscle Relaxation; Muscle, Smooth, Vascular; Neuromuscular Depolarizing Agents; Optical Rotation; Pyrazines; Pyrroles; Quinoxalines; Rabbits; Spectrophotometry, Infrared; Structure-Activity Relationship

1984
K+ channel openers produce epithelium-dependent relaxation of the guinea-pig trachea.
    European journal of pharmacology, 1995, Aug-25, Volume: 282, Issue:1-3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arginine; Benzopyrans; Cromakalim; Epithelium; Guinea Pigs; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Piperidines; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Thromboxane A2; Trachea; Vasoactive Intestinal Peptide

1995
Pharmacologic profiles of YM934, a novel potassium channel opener.
    Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:2

    Topics: Anesthesia; Animals; Aorta; Benzopyrans; Benzoxazines; Cromakalim; Cyclic N-Oxides; Dogs; Female; Hemodynamics; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Oxazines; Portal Vein; Potassium Channels; Pyrroles; Rabbits; Rats; Rats, Wistar; Vascular Resistance; Vasodilation

1994
Potassium channel opening properties of thiazide diuretics in isolated guinea pig resistance arteries.
    Journal of cardiovascular pharmacology, 1994, Volume: 24, Issue:1

    Topics: Animals; Benzopyrans; Cromakalim; Diuretics; Guinea Pigs; Hydrochlorothiazide; Indapamide; Mesenteric Arteries; Muscle Relaxation; Potassium Channel Blockers; Potassium Channels; Pyrroles; Sodium Chloride Symporter Inhibitors; Vascular Resistance

1994
Response of guinea pig smooth and striated urethral sphincter to cromakalim, prazosin, nifedipine, nitroprusside, and electrical stimulation.
    Neurourology and urodynamics, 1995, Volume: 14, Issue:2

    Topics: Amino Acid Oxidoreductases; Animals; Antihypertensive Agents; Benzopyrans; Calcium; Calmodulin-Binding Proteins; Cromakalim; Decamethonium Compounds; Electric Stimulation; Guinea Pigs; Hexamethonium; Histocytochemistry; Male; Muscle Contraction; Muscle Relaxation; Muscle, Skeletal; Muscle, Smooth; Nifedipine; Nitric Oxide Synthase; Nitroprusside; Prazosin; Pyrroles; Urethra

1995
Calcitonin gene-related peptide mediated neurogenic vasorelaxation in the isolated canine lingual artery.
    Japanese journal of pharmacology, 1995, Volume: 67, Issue:4

    Topics: Animals; Arginine; Benzopyrans; Calcitonin Gene-Related Peptide; Capsaicin; Cromakalim; Dogs; Electric Stimulation; Female; Glyburide; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; omega-N-Methylarginine; Peptide Fragments; Potassium Channel Blockers; Potassium Channels; Propranolol; Pyrroles; Substance P; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin; Vasoconstriction; Vasodilator Agents

1995
Barium inhibits the endothelium-dependent component of flow but not acetylcholine-induced relaxation in isolated rabbit cerebral arteries.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:1

    Topics: Acetylcholine; Animals; Barium Compounds; Benzopyrans; Cerebral Arteries; Chlorides; Cromakalim; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Relaxation; Nitroprusside; Potassium Channel Blockers; Pyrroles; Rabbits

1995
K+ channels and guinea-pig trachea: a possible functional modulation by GABAB receptors.
    Pulmonary pharmacology, 1994, Volume: 7, Issue:4

    Topics: Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Electric Stimulation; Guinea Pigs; Male; Muscle Relaxation; Neuromuscular Junction; Potassium Channels; Pyrroles; Receptors, GABA-B; Trachea

1994
Involvement of K+ channels in the relaxant responses to various agonists in estrogen primed rat uterus.
    Indian journal of physiology and pharmacology, 1995, Volume: 39, Issue:2

    Topics: Animals; Benzopyrans; Calcium; Cromakalim; Dose-Response Relationship, Drug; Epinephrine; Estrogens; Female; Guanidines; Histamine; Isoproterenol; Muscle Relaxation; Muscle, Smooth; Pinacidil; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Uterine Contraction; Uterus; Vasodilator Agents

1995
Calcitonin gene-related peptide relaxes porcine coronary arteries via cyclic AMP-dependent mechanisms, but not activation of ATP-sensitive potassium channels.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Calcium; Coronary Vessels; Cromakalim; Cyclic AMP; Endothelins; In Vitro Techniques; Isoproterenol; Muscle Relaxation; Potassium Channels; Pyrroles; Swine; Vasodilation

1993
The endothelium mediates a nitric oxide-independent hyperpolarization and relaxation in the rat hepatic artery.
    Acta physiologica Scandinavica, 1994, Volume: 152, Issue:4

    Topics: Acetylcholine; Animals; Arginine; Benzopyrans; Cell Polarity; Cromakalim; Endothelium, Vascular; Female; Hepatic Artery; Indomethacin; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Nimodipine; Nitric Oxide; Nitroarginine; Phenylephrine; Prazosin; Pyrroles; Rats; Rats, Sprague-Dawley

1994
Drug-induced endothelium-dependent and -independent relaxations in isolated resistance vessels taken from simultaneously hypertensive and streptozotocin-diabetic rats.
    Blood pressure, 1994, Volume: 3, Issue:6

    Topics: Animals; Benzopyrans; Bradykinin; Calcium; Cromakalim; Diabetes Mellitus, Experimental; Endothelium, Vascular; Glyburide; Histamine; Hypertension; Male; Mesenteric Arteries; Methacholine Chloride; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nitroprusside; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Streptozocin; Vascular Resistance; Vasodilation; Vasodilator Agents

1994
Cardioprotective profile of the cardiac-selective ATP-sensitive potassium channel opener BMS-180448.
    Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:1

    Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Aorta; Benzopyrans; Cromakalim; Decanoic Acids; Dogs; Female; Glyburide; Guanidines; Guinea Pigs; Heart; Heart Ventricles; Hydroxy Acids; In Vitro Techniques; Injections, Intravenous; Injections, Subcutaneous; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Ischemia; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents

1995
The inhibitory mechanisms of nicorandil in isolated rat urinary bladder and femoral artery.
    European journal of pharmacology, 1995, Jan-24, Volume: 273, Issue:1-2

    Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Cyclic GMP; Electric Stimulation; Femoral Artery; Guanylate Cyclase; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Urinary Bladder; Vasodilator Agents

1995
Glibenclamide inhibits hypoxic relaxation of isolated porcine coronary arteries under conditions of impaired glycolysis.
    European journal of pharmacology, 1994, Aug-03, Volume: 270, Issue:4

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Deoxyglucose; Endothelium, Vascular; Glyburide; Glycolysis; Hypoxia; In Vitro Techniques; Indomethacin; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Swine; Theophylline; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents

1994
Differential effects of pinacidil and cromakalim on vascular relaxation and sympathetic neurotransmission.
    Canadian journal of physiology and pharmacology, 1994, Volume: 72, Issue:7

    Topics: Animals; Benzopyrans; Cattle; Cromakalim; Dogs; Electric Stimulation; Female; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Pinacidil; Potassium Chloride; Pyrroles; Sympathetic Nervous System; Synaptic Transmission; Vasodilator Agents

1994
Characterization of ATP-sensitive potassium channel-blocking activity of ZENECA ZM181,037, a eukalemic diuretic.
    Pharmacology, 1994, Volume: 49, Issue:4

    Topics: Acetamides; Adenosine Triphosphate; Administration, Oral; Animals; Benzopyrans; Blood Glucose; Blood Pressure; Cromakalim; Diuretics; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Glyburide; Guinea Pigs; Hypertension; In Vitro Techniques; Injections, Intravenous; Male; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Potassium Channel Blockers; Pyrroles; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Stereoisomerism; Tolbutamide

1994
Light-dependent effects of zinc protoporphyrin IX on endothelium-dependent relaxation resistant to N omega-nitro-L-arginine.
    Acta physiologica Scandinavica, 1994, Volume: 152, Issue:2

    Topics: Acetylcholine; Animals; Arginine; Benzopyrans; Biliverdine; Carbon Monoxide; Cromakalim; Darkness; Endothelium, Vascular; Female; Heme Oxygenase (Decyclizing); Hepatic Artery; In Vitro Techniques; Indomethacin; Light; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Oxyhemoglobins; Phenylephrine; Potassium; Potassium Channels; Protoporphyrins; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents

1994
Regional and species differences in glyburide-sensitive K+ channels in airway smooth muscles as estimated from actions of KC 128 and levcromakalim.
    British journal of pharmacology, 1994, Volume: 113, Issue:3

    Topics: Animals; Benzopyrans; Bronchi; Carbachol; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Guinea Pigs; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Species Specificity; Trachea

1994
Potassium channel openers relax A23187-induced nifedipine-resistant contraction of rat aorta.
    Journal of cardiovascular pharmacology, 1994, Volume: 24, Issue:6

    Topics: Animals; Aorta; Benzopyrans; Calcimycin; Cromakalim; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Oxadiazoles; Piperidines; Pyrroles; Rats; Rats, Wistar; Vasoconstriction; Vasodilator Agents

1994
Mechanisms of vasorelaxation induced by N-allylsecoboldine in rat thoracic aorta.
    Naunyn-Schmiedeberg's archives of pharmacology, 1994, Volume: 349, Issue:6

    Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Aorta, Thoracic; Aporphines; Benzopyrans; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphatidylinositols; Potassium; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents; Verapamil

1994
Comparative effects of the potassium channel openers cromakalim and pinacidil and the cromakalim analog U-89232 on isolated vascular and cardiac tissue.
    Pharmacology, 1994, Volume: 49, Issue:2

    Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Guanidines; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents

1994
Differential effects of prostanoid synthesis inhibitors on cicletanine-induced relaxation of isolated human epigastric arteries.
    Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 1994, Volume: 4, Issue:3

    Topics: Abdominal Muscles; Antihypertensive Agents; Arteries; Benzopyrans; Cromakalim; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Humans; In Vitro Techniques; Indomethacin; Meclofenamic Acid; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Pyridines; Pyrroles; Tranylcypromine

1994
Differential vasodilator properties of KRN2391, cromakalim, nitroglycerin and nifedipine in rabbit isolated femoral artery and vein.
    British journal of pharmacology, 1994, Volume: 111, Issue:1

    Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Femoral Artery; Femoral Vein; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nitroglycerin; Pyridines; Pyrroles; Rabbits; Vasodilation; Vasodilator Agents

1994
Role of K+ channels in neuropeptide Y-induced vasoconstriction in rabbit cerebral basilar artery.
    European journal of pharmacology, 1994, Apr-01, Volume: 255, Issue:1-3

    Topics: Animals; Basilar Artery; Benzopyrans; Blood Pressure; Cromakalim; Diazoxide; Female; In Vitro Techniques; Male; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Neuropeptide Y; Potassium Channels; Pyrroles; Rabbits; Vasoconstrictor Agents

1994
Pilocarpine-induced relaxation of rat tail artery by a non-cholinergic mechanism and in the absence of an intact endothelium.
    British journal of pharmacology, 1994, Volume: 112, Issue:2

    Topics: Acetylcholine; Action Potentials; Animals; Arteries; Autonomic Nervous System; Benzopyrans; Cromakalim; Endothelium, Vascular; Female; In Vitro Techniques; Isoproterenol; Male; Membrane Potentials; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Phenylephrine; Pilocarpine; Pyrroles; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Tail

1994
Dissimilarity in the mechanisms of action of KRN2391, nicorandil and cromakalim in canine renal artery.
    The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:3

    Topics: Animals; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrates; Potassium Channels; Potassium Chloride; Pyridines; Pyrroles; Renal Artery; Vasodilator Agents

1993
Comparison of the effects of KRN2391 and other coronary dilators on porcine isolated coronary arteries of different sizes.
    The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:6

    Topics: Adenosine; Animals; Benzopyrans; Coronary Vessels; Cromakalim; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Pyridines; Pyrroles; Swine; Vasodilator Agents

1993
Mechanism of action of KRN2391 in canine coronary vascular bed.
    Japanese journal of pharmacology, 1993, Volume: 63, Issue:3

    Topics: Animals; Antihypertensive Agents; Arteries; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Drug Interactions; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyridines; Pyrroles; Vasodilator Agents

1993
The effect of a novel benzopyran derivative, KC 399, on the isolated guinea-pig trachealis and human bronchi.
    General pharmacology, 1993, Volume: 24, Issue:6

    Topics: Albuterol; Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; Guinea Pigs; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Trachea

1993
Role of potassium channels in hypoxic relaxation of porcine bronchi in vitro.
    The American journal of physiology, 1994, Volume: 266, Issue:3 Pt 1

    Topics: Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Carbachol; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hypoxia; In Vitro Techniques; Isoproterenol; Muscle Relaxation; Potassium Channels; Pyrroles; Swine

1994
Effects of antidiabetic sulphonylureas, cromakalim and their interaction in guinea-pig isolated tracheal smooth muscle.
    Pulmonary pharmacology, 1993, Volume: 6, Issue:3

    Topics: Animals; Benzopyrans; Cromakalim; Drug Interactions; Glipizide; Glyburide; Guinea Pigs; Hypoglycemic Agents; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Sulfonylurea Compounds; Trachea

1993
Partial inhibition by epithelium of tracheal smooth muscle relaxation induced by the potassium channel activator, BRL 38227.
    British journal of pharmacology, 1993, Volume: 110, Issue:1

    Topics: Aminophylline; Animals; Benzopyrans; Biotransformation; Bronchodilator Agents; Carbachol; Cromakalim; Epithelium; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Trachea

1993
Vasodilator action of cromakalim on human mesenteric artery.
    European journal of pharmacology, 1993, Aug-24, Volume: 240, Issue:2-3

    Topics: Aged; Aged, 80 and over; Benzopyrans; Cromakalim; Humans; In Vitro Techniques; Mesenteric Arteries; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Chloride; Pyrroles; Vasodilation; Vasodilator Agents

1993
RWJ 26629, a new potassium channel opener and vascular smooth muscle relaxant: a potential antihypertensive and antianginal agent.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:2

    Topics: Angina Pectoris; Animals; Antihypertensive Agents; Benzopyrans; Bronchoconstriction; Calcium Channel Blockers; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Ferrets; Gastrointestinal Motility; Guinea Pigs; Heart Atria; Macaca mulatta; Male; Mice; Mice, Inbred Strains; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrendipine; Papillary Muscles; Pilocarpine; Potassium Channels; Pyrans; Pyrroles; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Rubidium; Rubidium Radioisotopes; Thiophenes; Vasodilator Agents

1993
Endothelium-dependent hyperpolarization caused by bradykinin in human coronary arteries.
    The Journal of clinical investigation, 1993, Volume: 92, Issue:6

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Arginine; Benzopyrans; Bradykinin; Calcimycin; Child; Coronary Vessels; Cromakalim; Dinoprost; Endothelium, Vascular; Glyburide; Humans; In Vitro Techniques; Indoles; Indomethacin; Infant; Male; Membrane Potentials; Middle Aged; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Pyrroles; Vasodilator Agents

1993
Vasorelaxant mechanism of KRN2391 and nicorandil in porcine coronary arteries of different sizes.
    British journal of pharmacology, 1993, Volume: 109, Issue:3

    Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Glyburide; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Oxyhemoglobins; Potassium Channels; Pyridines; Pyrroles; Swine; Vasodilator Agents

1993
Sensitization decreases relaxation in human isolated airways.
    The American review of respiratory disease, 1993, Volume: 148, Issue:1

    Topics: Asthma; Benzopyrans; Bronchi; Bucladesine; Carbachol; Colforsin; Cromakalim; Dose-Response Relationship, Drug; Humans; Immunization, Passive; Immunoglobulin E; In Vitro Techniques; Isoproterenol; Muscle Relaxation; Muscle Tonus; Parasympatholytics; Pyrroles; Verapamil

1993
The relaxant actions on guinea-pig trachealis of atherosperminine isolated from Fissistigma glaucescens.
    European journal of pharmacology, 1993, Jun-11, Volume: 237, Issue:1

    Topics: Alkaloids; Animals; Benzopyrans; Calcium; Calmodulin; Colforsin; Cromakalim; Cyclic AMP; Cyclic GMP; Egtazic Acid; Epithelium; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nifedipine; Nitroprusside; Phenanthrenes; Plants, Medicinal; Propranolol; Pyrroles; Theophylline; Trachea; Vasodilator Agents

1993
Effects of rubidium on responses to potassium channel openers in rat isolated aorta.
    British journal of pharmacology, 1993, Volume: 109, Issue:4

    Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; In Vitro Techniques; Male; Microelectrodes; Muscle Relaxation; Muscle, Smooth, Vascular; Picolines; Portal Vein; Potassium Channels; Potassium Chloride; Potassium Radioisotopes; Pyrans; Pyrroles; Rats; Rats, Sprague-Dawley; Rubidium; Rubidium Radioisotopes; Tachyphylaxis; Vasodilator Agents

1993
Bronchodilating effects of the novel potassium channel opener HOE 234 in human airways in vitro.
    British journal of clinical pharmacology, 1993, Volume: 35, Issue:3

    Topics: Adenosine Triphosphate; Adult; Benzopyrans; Bronchi; Bronchodilator Agents; Chromans; Cromakalim; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Pyrrolidines

1993
Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660.
    Pulmonary pharmacology, 1993, Volume: 6, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Bronchi; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; Histamine; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Pinacidil; Potassium; Potassium Channels; Potassium Radioisotopes; Pyrroles; Pyrrolidines; Respiratory System; Trachea; Vasodilator Agents

1993
Selective and complete blockade of acetylcholine-induced relaxation in rabbit aortic rings by N omega-nitro-L-arginine but not by glybenclamide.
    European journal of pharmacology, 1993, Apr-06, Volume: 234, Issue:2-3

    Topics: Acetylcholine; Animals; Aorta, Abdominal; Arginine; Benzopyrans; Cromakalim; Endothelium, Vascular; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Nitroglycerin; Pyrroles; Rabbits; Vasodilator Agents

1993
8-(Diethylamino)-octyl-3,4,5-trimethoxybenzoate inhibits cromakalim-induced 86Rb efflux from the rat aorta.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:3

    Topics: Animals; Aorta; Benzopyrans; Biological Transport; Cromakalim; Gallic Acid; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Sprague-Dawley; Rubidium

1993
[Effects of the potassium channel activator cromakalim on human isolated bronchial smooth muscle].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 1995, Volume: 18, Issue:3

    Topics: Adult; Albuterol; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; Drug Synergism; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles

1995
K+ channel-opening properties of a novel compound, NIP-121, in guinea pig myocardium as compared with those of cromakalim.
    Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:4

    Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Hypoglycemic Agents; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardium; Oxadiazoles; Papillary Muscles; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyrroles; Vasodilator Agents

1995
Relaxation of subarachnoid hemorrhage-induced spasm of rabbit basilar artery by the K+ channel activator cromakalim.
    Stroke, 1996, Volume: 27, Issue:2

    Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; In Vitro Techniques; Ischemic Attack, Transient; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Potassium; Potassium Channels; Pyrroles; Rabbits; Subarachnoid Hemorrhage; Time Factors; Vasodilator Agents

1996
Effects of KRN2391, a novel vasodilator acting as a nitrate and a K+ channel opener, on the rabbit lower urinary tract.
    General pharmacology, 1995, Volume: 26, Issue:7

    Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Electrophysiology; Female; Hypoglycemic Agents; Molsidomine; Muscle Relaxation; Muscle, Smooth; Pyridines; Pyrroles; Rabbits; Urethra; Vasodilator Agents

1995
Effect of the K+ channel openers NIP-121 and cromakalim on melittin-induced relaxation of guinea-pig isolated trachea.
    Prostaglandins, 1996, Volume: 51, Issue:5

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Cromakalim; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Epithelium; Guinea Pigs; Histamine; Indomethacin; Leukotriene D4; Male; Melitten; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Phospholipases A; Phospholipases A2; Piperidines; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Thromboxane A2; Trachea

1996
Effects of cytochrome P450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery.
    British journal of pharmacology, 1996, Volume: 118, Issue:5

    Topics: Acetylcholine; Animals; Benzopyrans; Biological Factors; Clotrimazole; Cromakalim; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; Hepatic Artery; Indomethacin; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Potassium Channels; Proadifen; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents

1996
Effects of SCA40 on human bronchi and on guinea pig main bronchi in vitro. Comparison with cromakalim.
    Fundamental & clinical pharmacology, 1996, Volume: 10, Issue:4

    Topics: Acetylcholine; Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Capsaicin; Charybdotoxin; Cromakalim; Electric Stimulation; Female; Glyburide; Guinea Pigs; Humans; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurokinin A; Nitroprusside; Osmolar Concentration; Parasympatholytics; Potassium Channel Blockers; Potassium Channels; Pyrazines; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds

1996
Effects of SCA40 on human isolated bronchus and human polymorphonuclear leukocytes: comparison with rolipram, SKF94120 and levcromakalim.
    British journal of pharmacology, 1996, Volume: 119, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Bronchi; Bronchodilator Agents; Calcium; Cardiotonic Agents; Cromakalim; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; Imidazoles; In Vitro Techniques; Leukocyte Elastase; Leukotriene B4; Muscle Relaxation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoric Diester Hydrolases; Pyrazines; Pyrroles; Pyrrolidinones; Rolipram; Superoxides

1996
The inhibitory effects of iberiotoxin and 4-aminopyridine on the relaxation induced by beta 1- and beta 2-adrenoceptor activation in rat aortic rings.
    British journal of pharmacology, 1996, Volume: 119, Issue:3

    Topics: 4-Aminopyridine; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Aorta, Thoracic; Atenolol; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Imines; Indoles; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Peptides; Propanolamines; Pyrroles; Rats; Scorpion Venoms

1996
Effects of the potassium channel openers KRN4884 and levcromakalim on the contraction of rat aorta induced by A23187, compared with nifedipine.
    Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 354, Issue:4

    Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcimycin; Calcium; Calcium Channel Blockers; Cromakalim; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents

1996
The relaxant effect of extract of Phyllanthus urinaria in the guinea-pig isolated trachea. Evidence for involvement of ATP-sensitive potassium channels.
    The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:11

    Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Apamin; Benzopyrans; Calcitonin Gene-Related Peptide; Calcium; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Guinea Pigs; Hypoglycemic Agents; Male; Muscle Relaxation; Muscle, Smooth; Norepinephrine; Plant Extracts; Plants, Medicinal; Potassium Channels; Potassium Chloride; Propranolol; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds; Trachea

1996
Analysis of relaxation and repolarization mechanisms of nicorandil in rat mesenteric artery.
    British journal of pharmacology, 1996, Volume: 119, Issue:8

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Electrophysiology; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Arteries; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Rats; Rats, Sprague-Dawley; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents

1996
Relaxant effect of levcromakalim in isolated human small subcutaneous arteries.
    European journal of pharmacology, 1995, Dec-20, Volume: 287, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Adolescent; Adult; Arteries; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Drug Interactions; Female; Glyburide; Humans; In Vitro Techniques; Methacholine Chloride; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Skin; Thromboxane A2; Vasoconstrictor Agents

1995
Involvement of K+ channels in the relaxant effect of vasoactive intestinal peptide and atrial natriuretic peptide in isolated guinea-pig trachea.
    European journal of pharmacology, 1997, Jan-29, Volume: 319, Issue:2-3

    Topics: Adenosine Triphosphate; Animals; Atrial Natriuretic Factor; Benzopyrans; Calcium Channel Blockers; Cromakalim; Guinea Pigs; In Vitro Techniques; Isradipine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Trachea; Vasoactive Intestinal Peptide

1997
Structure-activity relationship of quaternary ion antagonism of levcromakalim-induced relaxation in pig coronary artery.
    European journal of pharmacology, 1997, Mar-12, Volume: 322, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzopyrans; Chemical Phenomena; Chemistry, Physical; Coronary Vessels; Cromakalim; Guanethidine; In Vitro Techniques; Ions; Muscle Relaxation; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Quaternary Ammonium Compounds; Structure-Activity Relationship; Swine; Tetraphenylborate; Thromboxane A2; Uncoupling Agents; Vasoconstrictor Agents; Vasodilator Agents

1997
Evaluation of BTS 67 582, a novel antidiabetic agent, in normal and diabetic rats.
    British journal of pharmacology, 1997, Volume: 120, Issue:6

    Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Glucose; Brain; Cromakalim; Diabetes Mellitus, Experimental; Diazoxide; Glucose; Glyburide; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Insulin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channel Blockers; Pyrroles; Rats; Rats, Wistar; Tumor Cells, Cultured

1997
Effects of putative K+ channel blockers on beta-adrenoceptor-mediated vasorelaxation of rat mesenteric artery.
    Journal of cardiovascular pharmacology, 1997, Volume: 29, Issue:4

    Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Barium; Benzopyrans; Calcium; Charybdotoxin; Colforsin; Cromakalim; Cyclic AMP; Dose-Response Relationship, Drug; Fenoterol; Glyburide; Isoproterenol; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Potassium Channel Blockers; Pyrroles; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasodilator Agents

1997
In vitro studies on the interactions of beta2-adrenoceptor agonists, methylxanthines, Ca2+-channel blockers, K+-channel openers and other airway smooth muscle relaxants in isolated guinea-pig trachea.
    European journal of pharmacology, 1997, May-20, Volume: 326, Issue:2-3

    Topics: Adrenergic beta-Agonists; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Drug Interactions; Female; Guinea Pigs; In Vitro Techniques; Isradipine; Male; Muscle Relaxation; Muscle, Smooth; Nitroprusside; Potassium Channels; Pyrroles; Regression Analysis; Terbutaline; Theophylline; Trachea; Vasodilator Agents

1997
Heterogeneity in the vasorelaxing effect of nicorandil on dog epicardial coronary arteries: comparison with other NO donors.
    Journal of cardiovascular pharmacology, 1997, Volume: 29, Issue:6

    Topics: Animals; Atrial Natriuretic Factor; Benzopyrans; Coronary Vessels; Cromakalim; Cyclic GMP; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxyhemoglobins; Pyrroles; Vasodilator Agents

1997
Influence of cytochrome P-450 inhibitors on endothelium-dependent nitro-L-arginine-resistant relaxation and cromakalim-induced relaxation in rat mesenteric arteries.
    Journal of cardiovascular pharmacology, 1997, Volume: 29, Issue:6

    Topics: Acetylcholine; Animals; Benzopyrans; Biological Factors; Cromakalim; Cytochrome P-450 Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; In Vitro Techniques; Mesenteric Arteries; Miconazole; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Proadifen; Pyrroles; Rats; Rats, Wistar; Triazoles; Vasodilator Agents

1997
Possible involvement of ATP-dependent K-channel related mechanisms in the antihypertensive and cough suppressant effects of the novel ACE inhibitor (2S, 3aS, 7aS)-1-(N2-nicotinoyl-L-lysyl-gamma-D-glutamyl)octahydro-1H- indole-2-carboxylic acid.
    Arzneimittel-Forschung, 1997, Volume: 47, Issue:6

    Topics: Adenosine Triphosphate; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Antitussive Agents; Aorta, Thoracic; Benzopyrans; Blood Pressure; Cromakalim; Dipeptides; Glyburide; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar

1997
The comparison of the responsiveness of human isolated internal mammary and gastroepiploic arteries to levcromakalim: an alternative approach to the management of graft spasm.
    British journal of clinical pharmacology, 1997, Volume: 44, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arteries; Benzopyrans; Coronary Artery Bypass; Cromakalim; Endothelin-1; Female; Glyburide; Humans; In Vitro Techniques; Indomethacin; Male; Mammary Arteries; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Omentum; Potassium; Potassium Channel Blockers; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Stomach; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents

1997
Bradykinin, lemakalim and sodium nitroprusside relax the mouse trachea in vitro by different mechanisms.
    Life sciences, 1997, Volume: 61, Issue:7

    Topics: Animals; Benzopyrans; Bradykinin; Cromakalim; Female; Male; Mice; Mice, Inbred BALB C; Muscle Relaxation; Nitroprusside; Potassium Channels; Pyrroles; Trachea

1997
Relaxant effects of potassium-channel openers on normal and hyper-reflexic detrusor muscle.
    British journal of urology, 1997, Volume: 80, Issue:3

    Topics: Benzopyrans; Benzoxazines; Carbachol; Cromakalim; Cyclic N-Oxides; Dose-Response Relationship, Drug; Electric Stimulation; Humans; Muscle Relaxation; Oxazines; Parasympatholytics; Potassium Channels; Pyrroles; Reflex, Abnormal; Urinary Bladder

1997
Protein kinase G expression in the small intestine and functional importance for smooth muscle relaxation.
    The American journal of physiology, 1998, Volume: 275, Issue:4

    Topics: Alkaloids; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Guinea Pigs; Indoles; Intestinal Mucosa; Intestine, Small; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Myenteric Plexus; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Polymerase Chain Reaction; Pyrroles; Rats; Rats, Wistar; Thionucleotides

1998
5-HT4 receptors in isolated human corpus cavernosum?
    International journal of impotence research, 1999, Volume: 11, Issue:4

    Topics: 4-Aminobenzoic Acid; Adrenergic beta-Antagonists; Benzamides; Humans; Male; Methysergide; Muscle Relaxation; Norepinephrine; para-Aminobenzoates; Penis; Pindolol; Pyrroles; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Serotonin Receptor Agonists

1999
Interplay between nitric oxide and vasoactive intestinal polypeptide in the pig gastric fundus smooth muscle.
    European journal of pharmacology, 2000, Jun-02, Volume: 397, Issue:2-3

    Topics: Adenine; Adenylyl Cyclase Inhibitors; Amidines; Animals; Arginine; Benzylamines; Carbazoles; Colforsin; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastric Fundus; In Vitro Techniques; Indoles; Isoquinolines; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Oxadiazoles; Protein Kinase Inhibitors; Pyrroles; Quinoxalines; Sulfonamides; Swine; Thionucleotides; Vasoactive Intestinal Peptide

2000
Okadaic acid inhibits relaxant neural transmission in rat gastric fundus in vitro.
    Acta physiologica Scandinavica, 2002, Volume: 175, Issue:1

    Topics: Animals; Carbazoles; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; Gastrointestinal Agents; Hydrazines; In Vitro Techniques; Indoles; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitrogen Oxides; Okadaic Acid; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Purinones; Pyrroles; Quinoxalines; Rats; Rats, Wistar; Synaptic Transmission; Vasoactive Intestinal Peptide

2002
Changes in responsiveness of the aorta to vasorelaxant agents in genetically diabetic rats: a study in WBN/Kob rats.
    Life sciences, 1992, Volume: 50, Issue:18

    Topics: Animals; Aorta, Thoracic; Benzopyrans; Colforsin; Cromakalim; Diabetes Mellitus, Experimental; Endothelium, Vascular; Isoproterenol; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Vasodilator Agents

1992
One way cross tolerance between cromakalim and salbutamol in the uterus of the rat in vivo.
    British journal of pharmacology, 1992, Volume: 105, Issue:1

    Topics: Albuterol; Animals; Benzopyrans; Cromakalim; Cyclic AMP; Drug Interactions; Drug Tolerance; Female; Glyburide; Muscle Relaxation; Propranolol; Pyrroles; Radioimmunoassay; Rats; Uterus

1992
Pharmacological interaction experiments differentiate between glibenclamide-sensitive K+ channels and cyclic GMP as components of vasodilation by nicorandil.
    European journal of pharmacology, 1992, Apr-29, Volume: 215, Issue:1

    Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Drug Interactions; Glyburide; Guanidines; In Vitro Techniques; Methylene Blue; Molsidomine; Muscle Relaxation; Niacinamide; Nicorandil; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Sensitivity and Specificity; Vasodilator Agents

1992
Potassium channel openers, NIP-121 and cromakalim, enhance the relaxation induced by sodium nitroprusside in the guinea-pig isolated trachea.
    British journal of pharmacology, 1992, Volume: 107, Issue:4

    Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Drug Interactions; Epithelium; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitroprusside; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles; SRS-A; Trachea; Vasodilator Agents

1992
Calmidazolium, a calmodulin inhibitor, inhibits endothelium-dependent relaxations resistant to nitro-L-arginine in the canine coronary artery.
    British journal of pharmacology, 1992, Volume: 107, Issue:2

    Topics: Adenosine Diphosphate; Adrenergic beta-Antagonists; Animals; Arginine; Benzopyrans; Bradykinin; Calcimycin; Calmodulin; Coronary Vessels; Cromakalim; Dogs; Endothelium, Vascular; Ethanolamines; Imidazoles; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Nebivolol; Nitric Oxide; Nitroarginine; Pyrroles; Vasodilator Agents

1992
Effects of cromakalim on the contraction and the membrane potential of the circular smooth muscle of guinea-pig stomach.
    British journal of pharmacology, 1992, Volume: 105, Issue:2

    Topics: Acetylcholine; Animals; Benzopyrans; Charybdotoxin; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Pyrroles; Scorpion Venoms; Stomach

1992
Vasorelaxing effect in rat thoracic aorta caused by fraxinellone and dictamine isolated from the Chinese herb Dictamnus dasycarpus Turcz: comparison with cromakalim and Ca2+ channel blockers.
    Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 345, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Aorta, Thoracic; Benzofurans; Benzopyrans; Calcium; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Drugs, Chinese Herbal; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Quinolines; Rats; Rats, Inbred Strains; Verapamil

1992
Role of potassium channels in bronchodilator responses in human airways.
    The American review of respiratory disease, 1992, Volume: 146, Issue:1

    Topics: Adolescent; Adult; Apamin; Benzopyrans; Bronchi; Bronchodilator Agents; Charybdotoxin; Child; Cromakalim; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Isoproterenol; Muscle Relaxation; Potassium Channels; Pyrroles; Pyrrolidines; Scorpion Venoms; Theophylline

1992
Comparison of the relaxing effects of cicletanine and cromakalim on vascular smooth muscle.
    Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:1

    Topics: Animals; Antihypertensive Agents; Aorta; Benzopyrans; Cromakalim; Diuretics; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Iliac Artery; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Potassium; Pyridines; Pyrroles; Rabbits; Rats; Vasodilation; Vasodilator Agents

1992
Tracheal relaxation induced by potassium channel opening drugs: its antagonism by adrenergic neurone blocking agents.
    British journal of pharmacology, 1992, Volume: 106, Issue:4

    Topics: Adrenergic Antagonists; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Guanidines; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Parasympatholytics; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Rubidium Radioisotopes; Stereoisomerism; Theophylline; Trachea

1992
Effects of K+ channel blockers on the relaxant action of dihydralazine, cromakalim and nitroprusside in isolated rabbit femoral arteries.
    European journal of pharmacology, 1992, May-14, Volume: 215, Issue:2-3

    Topics: Animals; Benzopyrans; Cromakalim; Dihydralazine; Endothelium, Vascular; Female; Femoral Artery; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Norepinephrine; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents

1992
Inhibition by adrenergic neurone blocking agents of the relaxation induced by BRL 38227 in vascular, intestinal and uterine smooth muscle.
    British journal of pharmacology, 1992, Volume: 107, Issue:2

    Topics: Animals; Aorta, Thoracic; Benzopyrans; Bretylium Compounds; Cromakalim; Female; Guanethidine; Guinea Pigs; Intestines; Male; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Nitroprusside; Norepinephrine; Potassium Chloride; Pyrroles; Rats; Rats, Sprague-Dawley; Sympatholytics; Theophylline; Uterine Contraction

1992
Differential effects of endothelin-1 on the vasorelaxant properties of benzopyran and non-benzopyran potassium channel openers.
    British journal of pharmacology, 1992, Volume: 107, Issue:1

    Topics: Animals; Aorta; Benzopyrans; Cromakalim; Cyclopentanes; Dihydropyridines; Dose-Response Relationship, Drug; Endothelins; Guanidines; Hypertension; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents

1992
The relaxant effects of cromakalim (BRL 34915) on human isolated airway smooth muscle.
    Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 346, Issue:4

    Topics: Acetylcholine; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; Drug Interactions; Histamine; Humans; Isoproterenol; Muscle Relaxation; Muscle, Smooth; Pyrroles; SRS-A; Theophylline

1992
Effect of Rb+ on cromakalim-induced relaxation and ion fluxes in guinea pig trachea.
    European journal of pharmacology, 1992, Nov-03, Volume: 222, Issue:1

    Topics: Albuterol; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Potassium; Pyrroles; Rubidium; Rubidium Radioisotopes; Trachea; Verapamil

1992
Evidence that epithelium-dependent relaxation of vascular smooth muscle detected by co-axial bioassays is not attributable to hypoxia.
    British journal of pharmacology, 1992, Volume: 105, Issue:4

    Topics: Animals; Aorta; Benzopyrans; Biological Assay; Biological Factors; Cromakalim; Epithelium; Glyburide; Guinea Pigs; Hypoxia; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Pyrroles; Rats; Rats, Inbred Strains; Respiratory Physiological Phenomena

1992
Comparison of the actions of acetylcholine and BRL 38227 in the guinea-pig coronary artery.
    British journal of pharmacology, 1992, Volume: 106, Issue:1

    Topics: Acetylcholine; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Pyridines; Pyrroles; Rabbits; Scorpion Venoms; Vasodilator Agents

1992
Effects of the K+ channel blocker tedisamil on 86Rb efflux induced by cromakalim, high potassium and noradrenaline, and on mechanical tension in rabbit isolated vascular smooth muscle.
    Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 345, Issue:2

    Topics: Animals; Aorta; Benzopyrans; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cardiotonic Agents; Cromakalim; Cyclopropanes; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Rubidium

1992
Differential inhibition by tedisamil (KC 8857) and glibenclamide of the responses to cromakalim and minoxidil sulphate in rat isolated aorta.
    Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 345, Issue:2

    Topics: Animals; Aorta; Benzopyrans; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cromakalim; Cyclopropanes; Glyburide; Male; Minoxidil; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium

1992
Relaxant effects of BRL 38227 and pinacidil on the rat gastric fundus.
    European journal of pharmacology, 1992, Apr-07, Volume: 214, Issue:1

    Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Gastric Fundus; Glyburide; Guanidines; In Vitro Techniques; Male; Muscle Relaxation; Phentolamine; Pinacidil; Potassium Channels; Pyrroles; Rats; Vasodilator Agents

1992
Airway pharmacology of the potassium channel opener, HOE 234, in guinea pigs: in vitro and in vivo studies.
    European journal of pharmacology, 1992, Jan-07, Volume: 210, Issue:1

    Topics: Animals; Benzopyrans; Bronchoconstrictor Agents; Bronchodilator Agents; Carbachol; Chromans; Cromakalim; Dinoprostone; Female; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Pyrrolidines; Trachea

1992
Smooth muscle relaxation and inhibition of responses to pinacidil and cromakalim induced by phentolamine in guinea-pig isolated trachea.
    European journal of pharmacology, 1992, Feb-11, Volume: 211, Issue:2

    Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dinoprost; Female; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phentolamine; Pinacidil; Pyrroles; SRS-A; Trachea

1992
Effects of cromakalim on neurally-mediated responses of guinea-pig tracheal smooth muscle.
    British journal of pharmacology, 1991, Volume: 104, Issue:1

    Topics: Animals; Autonomic Nervous System; Benzopyrans; Bronchodilator Agents; Cromakalim; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neuromuscular Junction; Neurons; Parasympathetic Nervous System; Pyrroles; Synaptic Transmission; Trachea; Vagus Nerve

1991
Mechanical, biochemical and electrophysiological studies of RP 49356 and cromakalim in guinea-pig and bovine trachealis muscle.
    Pulmonary pharmacology, 1991, Volume: 4, Issue:2

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Benzopyrans; Bronchodilator Agents; Calcium; Cattle; Cromakalim; Cyclic AMP; Electrophysiology; Guinea Pigs; In Vitro Techniques; Intracellular Fluid; Kinetics; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Picolines; Potassium Channels; Pyrans; Pyrroles; Trachea

1991
Characteristics of KRN2391, a novel vasodilator, compared with those of cromakalim, pinacidil and nifedipine in rat aorta.
    European journal of pharmacology, 1991, Apr-10, Volume: 196, Issue:1

    Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guanylate Cyclase; Male; Muscle Relaxation; Nifedipine; Nitrogen Dioxide; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Vasodilator Agents

1991
Rat peritoneal neutrophils selectively relax vascular smooth muscle.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:3

    Topics: Animals; Aorta, Thoracic; Atrial Function; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Female; Femoral Artery; Guanylate Cyclase; Guinea Pigs; Heart Atria; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Neutrophils; Nitric Oxide; Nitroprusside; Peritoneal Cavity; Pyrroles; Rabbits; Rats; Rats, Inbred Lew; Saphenous Vein; Trachea

1991
Selective inhibition of relaxation of guinea-pig trachea by charybdotoxin, a potent Ca(++)-activated K+ channel inhibitor.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:2

    Topics: Aminophylline; Animals; Benzopyrans; Calcium; Carbachol; Charybdotoxin; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Scorpion Venoms; Serotonin; Trachea

1990
Effects of cromakalim, RP49356, diazoxide, glibenclamide and galanin in rat portal vein.
    European journal of pharmacology, 1990, Nov-06, Volume: 190, Issue:1-2

    Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Galanin; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Peptides; Picolines; Portal Vein; Potassium Channels; Pyrans; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Vasodilator Agents

1990
Guinea-pig isolated trachealis: the effects of charybdotoxin on mechanical activity, membrane potential changes and the activity of plasmalemmal K(+)-channels.
    British journal of pharmacology, 1991, Volume: 103, Issue:3

    Topics: Adrenergic beta-Agonists; Animals; Benzopyrans; Calcium; Cell Membrane; Charybdotoxin; Cromakalim; Guinea Pigs; In Vitro Techniques; Isoproterenol; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Picolines; Potassium Channels; Pyrans; Pyrroles; Scorpion Venoms; Theophylline; Trachea; Vasodilator Agents

1991
ATP-sensitive potassium channels do not mediate vasorelaxation by acetylcholine or iloprost.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1991, Volume: 24, Issue:7

    Topics: Acetylcholine; Adenosine Triphosphate; Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Electric Stimulation; Endothelium, Vascular; Glyburide; Iloprost; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vasodilation

1991
Different mechanisms of relaxation of pig coronary artery to bradykinin and cromakalim are distinguished by potassium channel blockers.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:1

    Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Benzopyrans; Bradykinin; Calcium; Coronary Vessels; Cromakalim; In Vitro Techniques; Methylene Blue; Muscle Relaxation; Potassium Channels; Procaine; Pyrroles; Quinine; Swine; Tetraethylammonium; Tetraethylammonium Compounds

1992
Actions of cromakalim in isolated human saphenous vein.
    Hypertension (Dallas, Tex. : 1979), 1992, Volume: 19, Issue:2 Suppl

    Topics: Antihypertensive Agents; Benzopyrans; Cromakalim; Dinoprost; Glyburide; Humans; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Norepinephrine; Potassium Chloride; Pyrroles; Saphenous Vein; Serotonin; Vasoconstriction

1992
Antidiabetic sulfonylureas relax isolated rabbit coronary arteries.
    European journal of pharmacology, 1991, Dec-17, Volume: 209, Issue:3

    Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dinoprost; Hypoglycemic Agents; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium; Pyrroles; Rabbits; Sulfonylurea Compounds; Vasodilator Agents

1991
Evaluation of the potassium channel activator BRL 38227 as an inhaled bronchodilator in the guinea-pig: contrast with nifedipine and salbutamol.
    Pulmonary pharmacology, 1991, Volume: 4, Issue:2

    Topics: Administration, Inhalation; Airway Resistance; Albuterol; Aminophylline; Animals; Benzopyrans; Bronchoconstriction; Bronchodilator Agents; Cromakalim; Drug Evaluation, Preclinical; Guinea Pigs; Histamine; Lung; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Potassium Channels; Pyrroles

1991
NIP-121 and cromakalim, potassium channel openers, preferentially suppress prostanoid-induced contraction of the guinea-pig isolated trachea.
    European journal of pharmacology, 1991, Dec-10, Volume: 209, Issue:1-2

    Topics: Animals; Arachidonic Acid; Benzopyrans; Cromakalim; Dinoprost; Glyburide; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Piperidines; Potassium Channels; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Pyrroles; Sulfonamides; Trachea

1991
Potassium channel opening properties of a novel compound, NIP-121, cromakalim and nicorandil in rat aorta and portal vein.
    European journal of pharmacology, 1991, Apr-03, Volume: 195, Issue:3

    Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Oxadiazoles; Phentolamine; Piperidines; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes

1991
Relaxant activity of 6-cyano-2,2-dimethyl-2H-1-benzopyran-4-carboxamides and -thiocarboxamides and their analogues in guinea pig trachealis.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:8

    Topics: Animals; Benzopyrans; Bronchodilator Agents; Chemical Phenomena; Chemistry; Cromakalim; Guinea Pigs; Male; Molecular Structure; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Structure-Activity Relationship; Thioamides; Trachea

1991
RP 49356 and cromakalim relax airway smooth muscle in vitro by opening a sulphonylurea-sensitive K+ channel: a comparison with nifedipine.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:2

    Topics: Animals; Benzopyrans; Calcium; Cromakalim; Glipizide; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nifedipine; Picolines; Potassium Channels; Pyrans; Pyrroles; Trachea

1991
Spasmolytic effect of cromakalim in dog coronary artery in vitro.
    Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 343, Issue:5

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; In Vitro Techniques; Muscle Relaxation; Nitroglycerin; Nitroprusside; Parasympatholytics; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Serotonin; Vasodilator Agents

1991
Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:3

    Topics: Amides; Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Chemical Phenomena; Chemistry; Cromakalim; Guinea Pigs; Indans; Male; Molecular Structure; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Potassium Channels; Pyrroles; Stereoisomerism; Structure-Activity Relationship; Trachea

1991
Glibenclamide blocks the relaxant action of pinacidil and cromakalim in airway smooth muscle.
    European journal of pharmacology, 1990, May-16, Volume: 180, Issue:2-3

    Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth; Pinacidil; Pyrroles; Terbutaline; Theophylline; Trachea; Verapamil

1990
Evidence that pinacidil may promote the opening of ATP-sensitive K+ channels yet inhibit the opening of Ca2(+)-activated K+ channels in K(+)-contracted canine mesenteric artery.
    British journal of pharmacology, 1990, Volume: 100, Issue:1

    Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Dogs; Female; Glyburide; Guanidines; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rubidium Radioisotopes

1990
Hypoglycemic sulfonylureas antagonize the effects of cromakalim and pinacidil on 86Rb fluxes and contractile activity in the rat aorta.
    Pharmacology, 1990, Volume: 41, Issue:1

    Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Parasympatholytics; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Sulfonylurea Compounds; Tetraethylammonium Compounds; Tolbutamide; Vasodilator Agents

1990
Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicorandil.
    British journal of pharmacology, 1990, Volume: 101, Issue:1

    Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Cytoplasm; Dogs; Female; Fluorescence; Glyburide; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Chloride; Pyrroles; Quaternary Ammonium Compounds

1990
Relaxant activity of 4-amido-3,4-dihydro-2H-1-benzopyran-3-ols and 4-amido-2H-1-benzopyrans on guinea pig isolated trachealis.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:11

    Topics: Amides; Animals; Benzopyrans; Bronchodilator Agents; Chemical Phenomena; Chemistry; Cromakalim; Guinea Pigs; Molecular Structure; Muscle Relaxation; Potassium Channels; Pyrroles; Structure-Activity Relationship; Trachea

1990
K(+)-channel activators in vascular smooth muscle.
    Progress in clinical and biological research, 1990, Volume: 334

    Topics: Animals; Benzopyrans; Cromakalim; In Vitro Techniques; Isometric Contraction; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Potassium Radioisotopes; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Vasodilator Agents

1990
K(+)-channel openers for relaxation of isolated penile erectile tissue from rabbit.
    The Journal of urology, 1990, Volume: 144, Issue:1

    Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Papaverine; Penile Erection; Penis; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents

1990
Evaluation of the bronchodilator properties of Ro 31-6930, a novel potassium channel opener, in the guinea-pig.
    British journal of pharmacology, 1990, Volume: 100, Issue:2

    Topics: Albuterol; Anesthesia; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Decerebrate State; Drug Interactions; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyridines; Pyrroles; Seizures; Theophylline; Vagotomy

1990
Electrical and mechanical effects of BRL34915 in guinea-pig isolated trachealis.
    British journal of pharmacology, 1986, Volume: 89, Issue:2

    Topics: Acetylcholine; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Female; Guinea Pigs; Histamine; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Potassium Chloride; Pyrroles; Trachea

1986
Inhibition by glibenclamide of the vasorelaxant action of cromakalim in the rat.
    British journal of pharmacology, 1989, Volume: 97, Issue:1

    Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Pressure; Cromakalim; Glyburide; Heart Rate; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Parasympatholytics; Portal Vein; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes

1989
Cromakalim-induced relaxation of guinea-pig isolated trachealis: antagonism by glibenclamide and by phentolamine.
    British journal of pharmacology, 1989, Volume: 98, Issue:3

    Topics: Animals; Benzopyrans; Cromakalim; Electrophysiology; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Male; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Phentolamine; Potassium Channels; Pyrroles; Trachea

1989
Effects of glibenclamide on cromakalim-induced responses in rabbit isolated aorta.
    British journal of pharmacology, 1989, Volume: 98 Suppl

    Topics: Animals; Aorta; Benzopyrans; Cromakalim; Drug Interactions; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Parasympatholytics; Pyrroles; Rabbits

1989
Glibenclamide is a competitive antagonist of cromakalim, pinacidil and RP 49356 in guinea-pig pulmonary artery.
    European journal of pharmacology, 1989, Jun-20, Volume: 165, Issue:2-3

    Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Potassium Chloride; Pulmonary Artery; Purinones; Pyrans; Pyrroles; Tetraethylammonium Compounds

1989
Functional changes in potassium channels in aortas from rats with streptozotocin-induced diabetes.
    European journal of pharmacology, 1989, Jul-18, Volume: 166, Issue:2

    Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Glucose; Cromakalim; Diabetes Mellitus, Experimental; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Niacinamide; Nicorandil; Norepinephrine; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains

1989
The effect of relaxants working through different transduction mechanisms on the tonic contraction produced in rat aorta by 4 beta-phorbol dibutyrate.
    British journal of pharmacology, 1989, Volume: 97, Issue:3

    Topics: Animals; Aorta, Thoracic; Benzopyrans; Colforsin; Cromakalim; In Vitro Techniques; Isoproterenol; Male; Methoxamine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Parasympatholytics; Phorbol 12,13-Dibutyrate; Pyrroles; Rats; Rats, Inbred Strains; Xanthines

1989
Phentolamine and structurally related compounds selectively antagonize the vascular actions of the K+ channel opener, cromromakalim.
    British journal of pharmacology, 1989, Volume: 97, Issue:3

    Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Drug Interactions; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Phentolamine; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Rats; Rats, Inbred WKY

1989
Comparison of the effects of cromakalim, a potassium conductance enhancer, and nimodipine, a calcium antagonist, on 5-hydroxytryptamine responses in a variety of vascular smooth muscle preparations.
    Naunyn-Schmiedeberg's archives of pharmacology, 1989, Volume: 340, Issue:3

    Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Female; In Vitro Techniques; Ketanserin; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Nimodipine; Potassium Channels; Prazosin; Pyrroles; Rabbits; Serotonin Antagonists; Swine

1989
Effect of cromakalim on bronchoconstriction evoked by cholinergic nerve stimulation in guinea-pig isolated trachea.
    British journal of pharmacology, 1989, Volume: 98, Issue:2

    Topics: Acetylcholine; Animals; Benzopyrans; Bronchi; Cromakalim; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Parasympathetic Nervous System; Parasympatholytics; Pyrroles; Trachea; Vagus Nerve

1989
The lack of involvement of cyclic nucleotides in the smooth muscle relaxant action of BRL 34915.
    British journal of pharmacology, 1988, Volume: 94, Issue:4

    Topics: Animals; Antihypertensive Agents; Apamin; Benzopyrans; Cromakalim; Cyclic AMP; Cyclic GMP; Drug Interactions; Female; Guinea Pigs; Hemoglobins; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Pyrroles; Rabbits

1988
Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil.
    European journal of pharmacology, 1988, Aug-02, Volume: 152, Issue:3

    Topics: 4-Aminopyridine; Aminopyridines; Animals; Benzopyrans; Cardiovascular Agents; Cromakalim; Guanidines; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Procaine; Pyrroles; Rabbits; Rubidium Radioisotopes; Tetraethylammonium Compounds; Vasodilator Agents

1988
Increased vasodilator responsiveness to BRL 34915 in spontaneously hypertensive versus normotensive rats: contrast with nifedipine.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1989, Volume: 190, Issue:2

    Topics: Animals; Antihypertensive Agents; Aorta; Benzopyrans; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Phenylephrine; Pyrroles; Rats; Rats, Inbred SHR; Vascular Resistance; Vasodilation

1989
Characteristics of cromakalim-induced relaxations in the smooth muscle cells of guinea-pig mesenteric artery and vein.
    British journal of pharmacology, 1988, Volume: 95, Issue:3

    Topics: Action Potentials; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Female; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Arteries; Mesenteric Veins; Microelectrodes; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Vasodilator Agents

1988
Similarity of relaxations evoked by BRL 34915, pinacidil and field-stimulation in rat oesophageal tunica muscularis mucosae.
    British journal of pharmacology, 1988, Volume: 95, Issue:2

    Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Electric Stimulation; Esophagus; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nifedipine; Pinacidil; Potassium Channels; Pyrroles; Rats; Rubidium Radioisotopes; Tetrodotoxin

1988