pyrroles has been researched along with Muscle Contraction in 200 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (16.50) | 18.7374 |
| 1990's | 132 (66.00) | 18.2507 |
| 2000's | 20 (10.00) | 29.6817 |
| 2010's | 13 (6.50) | 24.3611 |
| 2020's | 2 (1.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bigby, TD; Breen, EC; Cannon, DT; Gilmore, NK; Gutierrez-Gonzalez, AK; Nogueira, L | 1 |
| Baj, A; Bistoletti, M; Giaroni, C; Marcozzi, C; Moriondo, A; Negrini, D; Solari, E | 1 |
| Cai, C; Lei, J; Liu, QH; Shen, J; Tan, H; Xue, L | 1 |
| Buikema, H; Duin, M; Duman-Dalkilic, B; Goris, M; Gurdal, H; Henning, RH; Landheer, SW; Mulder, GM; Ulu, N; van Dokkum, RP; van Goor, H; Vavrinec, P | 1 |
| Belló-Klein, A; Lehnen, AM; Lehnen, TE; Machado, UF; Markoski, MM; Schaan, B; Tavares, AM | 1 |
| Bedi, A; Davis, ME; Flood, MD; Gumucio, JP; Harning, JA; Lynch, EB; Mendias, CL; Oak, NR; Roche, SM; Saripalli, AL | 1 |
| Hashitani, H; Isogai, A; Lee, K; Mitsui, R | 1 |
| Amobi, N; Guillebaud, J; Smith, IC | 1 |
| Amobi, N; Guillebaud, J; Smith, CH | 1 |
| Bi, Q; Bolli, R; Dawn, B; Hunt, G; Peng, Y; Sanganalmath, SK; Sato, H; Shirk, G; Tang, XL; Vincent, RJ | 1 |
| Abd El-Aziz, SM; Abdel-Wahab, BA | 1 |
| Augeri, AL; Capizzi, JA; Grimaldi, AS; Michael White, C; Parker, BA; Thompson, PD | 1 |
| Amobi, NI; Guillebaud, J; Smith, IC | 1 |
| Dahan, D; Ducret, T; Estève, E; Marthan, R; Quignard, JF; Savineau, JP | 1 |
| Anderson, DG; Guo, L; Langer, R; Ma, M | 1 |
| GOODMAN, I; HIATT, RB | 1 |
| AZZONE, GF; DOBRILLA, G | 1 |
| Calixto, JB; El Sayah, M | 1 |
| Fukui, T; Hamada, K; Kimura, Y; Sasaki, Y; Tanaka, M; Ukai, Y | 1 |
| Doi, T; Nagabukuro, H; Okanishi, S | 1 |
| Aceto, MD; Breeden, S; Husbands, SM; Ko, MC; Lewis, JW; Neilan, CL; Traynor, JR; Woods, JH | 1 |
| Doi, T; Imai, S; Ishichi, Y; Ishihara, Y; Miwatashi, S; Nagabukuro, H; Okanishi, S; Saikawa, R; Sasaki, M; Setoh, M; Tsukamoto, T | 1 |
| Gibson, M; Greenwood Van-Meerveld, B; Myers, DA; Schulkin, J | 1 |
| Adelson, DA; Bayati, A; Chrousos, GP; Gauthier, A; Maillot, C; Mattsson, H; Million, M; Nozu, T; Rivier, J; Taché, Y | 1 |
| Abraham, NG; Bolognesi, M; Di Pascoli, M; Rodella, L; Sacerdoti, D; Turkseven, S | 1 |
| Becker, DP; Flynn, DL; Gullikson, GW; Loeffler, R; Moormann, AE; Moummi, C; Nosal, R; Villamil, CI; Yang, DC | 1 |
| Delliaux, S; Jammes, Y; Lesavre, N; Oliver, C; Paganelli, F; Steinberg, JG | 1 |
| Chiesa, G; Cippone, V; Conte Camerino, D; De Luca, A; De Vito, D; Didonna, MP; Frigeri, A; Nicchia, GP; Pierno, S; Pisoni, M; Rizzo, C; Scanziani, E; Sirtori, C; Svelto, M | 1 |
| Hatori, Y; Horie, S; Ishikawa, H; Kitajima, M; Matsumoto, K; Misawa, K; Murayama, T; Okada, N; Takayama, H; Tashima, K; Wongseripipatana, S | 1 |
| Cetin, A; Igdem, AA; Ozacmak, ID; Ozacmak, VH; Sayan, H | 1 |
| Fujisue, H; Kaneto, K; Sendai, T; Takashima, W; Yamato, K | 1 |
| Barbata, V; Benesch-Lee, F; Crawford, G; Reid, J; Shansky, J; Thorrez, L; Valentini, R; Vandenburgh, H | 1 |
| Diamond, S | 1 |
| Diamond, S; Medina, JL | 1 |
| Cheung, CW; Gigg, M; Hartley, SA; Jones, LM; Usowicz, MM | 1 |
| Kanwal, S; Trachte, GJ | 1 |
| Asano, M; Fujikura, T; Masuda, N; Matsumoto, Y; Shibasaki, K; Shirai, Y; Taguchi, T; Takenaka, T; Tsuzuki, R; Uchida, W | 1 |
| Asano, M; Masuzawa-Ito, K; Matsuda, T | 1 |
| Allescher, HD; Franck, H; Puschmann, A; Schusdziarra, V | 1 |
| Maggi, CA; Meini, S; Santicioli, P | 1 |
| Brock, GB; Lue, TF; Nunes, L; Riemer, RK; Tanagho, EA; von Heyden, B | 1 |
| Mellemkjaer, S; Nielsen-Kudsk, JE; Thirstrup, S | 2 |
| Aharony, D; Buckner, CK; Ellis, JL; Ghanekar, SV; Graham, A; Kays, JS; Little, J; Meeker, S; Miller, SC; Undem, BJ | 1 |
| Allen, DG; Duty, S | 1 |
| Jino, H; Kurahashi, K; Nakata, Y; Shimizu, Y; Shirahase, H; Usui, H | 1 |
| Schwietert, R; van Zwieten, PA; Wilffert, B; Wilhelm, D | 1 |
| Groschner, K; Kühberger, E; Kukovetz, WR | 1 |
| Bourreau, JP; Daniel, EE; Kwan, CY | 2 |
| Advenier, C; Martin, CA | 1 |
| Ginkawa, M; Kontani, H; Sakai, T | 1 |
| Algate, DR; Atterson, PR; Augustin, J; Beard, DJ; Jobling, CM; Laufer, S; Munt, PL; Tries, S | 1 |
| Hohenfellner, R; Jahnel, U; Nawrath, H; Wammack, R | 2 |
| Atwal, KS; D'Alonzo, AJ; Grover, GJ; McCullough, JR; Sargent, CA | 1 |
| Satake, N; Shibata, S; Zhou, Q | 1 |
| Parsons, AA; Schilling, L; Wahl, M | 1 |
| Cai, B; deBoisblanc, B; Gillott, D; Goharderakhshan, R; Greenberg, SS; Hao, Q; Hyman, A; Lippton, H; Summer, WR | 1 |
| Giuliani, S; Maggi, CA; Santicioli, P | 2 |
| Hirano, K; Kanaide, H; Ushio-Fukai, M | 1 |
| Hou, YS; Lee, SS; Teng, CM; Yu, SM | 1 |
| Bishop, BE; Doggrell, SA | 1 |
| Criddle, DN; Greenwood, IA; Weston, AH | 1 |
| Berry, JL; Chiu, P; Cook, SJ; Downing, SJ; Foster, RW; Small, RC | 1 |
| Drew, GM; Roach, AG; Trezise, DJ; Watts, IS; Weston, AH | 1 |
| Jun, JY; Kim, KW; Kim, SJ | 1 |
| Aubier, M; Brione, E; De Vernejoul, D; Pavlovic, D | 1 |
| Advenier, C; Dumas, JP; Dumas, M; Giudicelli, JF | 1 |
| Sargent, C; Smith, MA; Weselcouch, EO; Wilde, MW | 1 |
| MacDonald, E; McDonald, A; Scott, PJ; Wadsworth, RM | 1 |
| Casis, O; Garcia Rafanell, J; Gomez, LA; Perez-Vizcaino, F; Rodriguez, R; Tamargo, J | 1 |
| Kamei, K; Kuriyama, H; Nabata, H | 1 |
| Ha, JH; Kim, WJ; Lee, KY | 1 |
| Flynn, DL; Goldstin, B; Gullikson, GW; Loeffler, RF; Moummi, C; Virina, MA; Wang, SX; Yang, DC; Zabrowski, DL | 1 |
| Flynn, DL; Goldstin, B; Gullikson, GW; Moormann, AE; Yang, DC | 1 |
| Brading, AF; Huang, SM; Katayama, N; Tomita, T | 1 |
| Brewster, M; Gater, PR; McKean, JC; Paciorek, PM; Waterfall, JF; Wilson, K | 1 |
| Marthan, R; Savineau, JP | 1 |
| D'Aguinaga, S; de Mello, RF; de Moura, RS | 1 |
| Creed, KE; Malmgren, A | 1 |
| Quast, U; Villhauer, EB | 1 |
| Bonasso, CL; Lewis, AI; Rapoport, RM; Sperelakis, N; Zuccarello, M | 1 |
| de Lemos Neto, M; de Moura, RS | 1 |
| Kelly, E; Kumar, P; Poucher, SM; Prior, H; Russell, K; Wickenden, AD | 1 |
| Karaki, H; Mitsui-Saito, M; Ozaki, H; Trongvanichnam, K | 1 |
| Bertelsen, DL; Chun, A; Kau, S; Levin, RM; Murphy, J | 1 |
| Kam, KL; Pfaffendorf, M; van Zwieten, PA | 1 |
| Advenier, C; Bakdach, H; Bonnet, PA; Cui, YY; Michel, A; Naline, E | 1 |
| Asano, M; Ito, K; Kuwako, M; Nomura, Y; Shibuya, M; Sugita, K; Suzuki, Y | 1 |
| Coupar, IM; McLean, PG; Molenaar, P | 1 |
| Nielsen-Kudsk, JE | 1 |
| Hüsken, BC; Pfaffendorf, M; Timmenga, EJ; Van Zwieten, PA; Vroom, MB | 1 |
| Ballejo, G; Corrado, AP; Cruz-Höfling, MA; Heluany, NF; Leite, GB; Prado-Franceschi, J; Rodrigues-Simioni, L; Silva-Carvalho, I | 1 |
| Huang, Y; Kwok, KH | 1 |
| Burton, FL; Smith, GL | 1 |
| Ando, T; Kume, H; Takagi, K; Urata, Y | 1 |
| Chuliá, S; D'Ocon, P; Ivorra, MD; Noguera, MA | 1 |
| Kinoshita, M; Liu, Q; Matsumoto, T; Nakae, I; Omura, T; Takahashi, M; Takaoka, A | 1 |
| Van de Voorde, J; Vanheel, B | 1 |
| Hosoki, K; Karasawa, T; Nagata, S; Takeyama, K | 1 |
| Akar, F; Aşlamaci, S; Kanzik, I; Köksoy, C; Tufan, H; Uydeş-Dogan, BS | 1 |
| Lee, BH; Seo, HW; Shin, HS; Yoo, SE | 1 |
| Barlocco, D; Cignarella, G; Leonardi, A; Mella, M; Montesano, F; Toma, L | 1 |
| Frohlich, BH; Gregg, RE; Tesfamariam, B | 1 |
| Jo, H; Komalavilas, P; Lincoln, TM; Shah, PK | 1 |
| Egan, RW; Hey, JA; Kreutner, W; Rizzo, CA; Valentine, AF | 1 |
| Akuzawa, S; Ito, H; Iwaoka, K; Kamato, T; Kiso, T; Miyata, K; Nagakura, Y; Naitoh, Y; Sakai, H; Suzuki, M; Yamaguchi, T; Yamano, M; Yuki, H | 1 |
| Imamura, H; Inagaki, C; Kawasaki, H; Mishima, K; Otani, H | 1 |
| el-Semary, MM; Elz, S; Farghaly, AM; Lehmann, J; Rostom, SA; Soliman, FS | 1 |
| Dekura, E; Kojima, F; Kosugi, Y; Naraba, H; Oh-ishi, S; Ueno, A; Yoshimura, M | 1 |
| Ito, H; Iwaoka, K; Kiso, T; Miyata, K; Nagakura, Y; Yamaguchi, T | 1 |
| Gorchein, A; Rogers, AT | 1 |
| Ryan, RE | 1 |
| Gorchein, A; Mitchell, LD; Rogers, AT | 1 |
| Von Schwarzenfeld, I; Whittaker, VP | 1 |
| Bell, MR; Bradford, JC; Hlavac, AG; McGarry, RH; Oesterlin, R; Rozitis, J | 1 |
| Barnes, PJ; Belvisi, MG; Miura, M; Stretton, CD; Yacoub, MH | 1 |
| Shikada, K; Tanaka, S | 1 |
| Cook, D; Stockbridge, N; Vollrath, B; Weir, B; Zhang, H | 1 |
| Bayguinov, O; Boev, K; Kortezova, N; Papasova, M | 1 |
| Asano, M; Ito, K; Kanno, T; Masuzawa-Ito, K; Ohashi, H; Suzuki, H; Suzuki, K; Takewaki, T | 1 |
| Huang, TF; Ko, FN; Su, MJ; Teng, CM; Wang, ML; Wu, TS; Yu, SM | 1 |
| Aikawa, T; Itabashi, S; Morikawa, M; Sasaki, H; Sekizawa, K; Takishima, T | 1 |
| Nielsen-Kudsk, JE; Thirstrup, S | 2 |
| Ichihara, K; Nagasaka, M; Okumura, K | 1 |
| Taira, N; Yamagishi, T; Yanagisawa, T | 1 |
| Alibhai, KN; Huizinga, JD; Richardson, D | 1 |
| Duty, S; Weston, AH | 1 |
| Arch, JR; Foster, KA; Newson, PN; Shaw, D; Taylor, SG | 1 |
| Andersson, PO; Criddle, D; Deitmer, P; Edwards, G; Greengrass, P; Morita, T; Noack, T; Weston, AH; Wyllie, MG | 1 |
| Eckman, DM; Frankovich, JD; Keef, KD | 1 |
| Shikada, K; Tanaka, S; Yamamoto, A | 2 |
| Kreye, VA; Pfründer, D; Theiss, U | 1 |
| Arch, JR; Bond, J; Buckle, DR; Shaw, DJ; Taylor, JF; Taylor, SG; Ward, JS | 1 |
| Bang, L; Nielsen-Kudsk, JE | 1 |
| Ashford, ML; Ben-Ari, Y; Zini, S | 1 |
| Berry, JL; Burka, JF; Foster, RW; Small, RC; Watt, AJ | 1 |
| Ito, K; Nishimura, K; Ota, M | 1 |
| Angel, I; Langer, SZ | 1 |
| Grant, TL; Zuzack, JS | 1 |
| Dwyer, TM; Farley, JM; Petrini, MF; Shieh, CC | 1 |
| de Moura, RS; Jasbik, W | 1 |
| Baumlin, Y; Quast, U | 1 |
| Ito, S; Itoh, T; Kajikuri, J; Kuriyama, H | 1 |
| Barbieri, A; Grana, E; Zonta, F | 2 |
| Cooper, J; Maclagan, J | 1 |
| Balwierczak, JL | 1 |
| Kreye, VA; Lenz, T; Theiss, U | 1 |
| Satoh, K; Taira, N; Yamada, H | 1 |
| Mundy, AR; Nurse, DE; Restorick, JM | 1 |
| Asano, M; Masuzawa, K; Matsuda, T | 2 |
| Grant, TL; Grimwood, S; Todd, MH; Wickenden, AD | 1 |
| Hirano, K; Kanaide, H; Yoshitake, K | 1 |
| Angus, JA; McPherson, GA | 2 |
| Cui, YY; Dong, YX; Li, JG; Lu, SN; Ma, SC; Wang, CQ; Zhang, KG | 1 |
| Bray, K; Quast, U | 1 |
| Altomare, C; Brigiani, GS; Carotti, A; Casini, G; Cellamare, S; Ferappi, M; Persichella, M | 1 |
| Fromm-Freeck, S; Hayes, L; Howe, BB; Kau, ST; Kitada, S; Levin, RM; Wein, AJ | 1 |
| Antoine, MH; Berkenboom, G; Fang, ZY; Fontaine, J; Herchuelz, A; Hermann, M; Lebrun, P | 1 |
| Taira, N; Teshigawara, T; Yanagisawa, T | 1 |
| Adeagbo, AS; Malik, KU | 1 |
| Dissanayake, VU; Hill, RG; Hughes, J; Hunter, JC | 1 |
| Kaneko, K; Miyata, N; Otomo, S; Tanaka, M; Tsuchida, K | 1 |
| Koch, P; Peters, T; Wilffert, B; Wilhelm, D | 1 |
| Kadlec, O; Masek, K; Seferna, I; Sevcík, J | 1 |
| Grafe, P; Lehmann-Horn, F; Quasthoff, S; Spittelmeister, W; Spuler, A | 1 |
| Andersson, KE; Andersson, PO; Fovaeus, M; Malmgren, A; Sjögren, C | 1 |
| Grafe, P; Lehmann-Horn, F; Quasthoff, S; Strupp, M | 1 |
| Andersson, KE; Fovaeus, M; Hedlund, H; Holmquist, F | 1 |
| Bühler, FR; Cauvin, C; Weir, SW | 1 |
| Dollery, CT; Turner, NC; Williams, AJ | 1 |
| Longmore, J; Weston, AH | 1 |
| den Hertog, A; Nelemans, A; Van den Akker, J | 1 |
| Eltze, M | 1 |
| Kamata, K; Kasuya, Y; Miyata, N | 1 |
| Cooper, SM; Wilson, C | 1 |
| Brading, AF; Foster, CD; Fujii, K; Speakman, MJ | 1 |
| Brading, AF; Foster, CD; Fujii, K; Kingdon, J | 1 |
| Dale, MM; Obianime, AW | 1 |
| Birchmore, B; Clark, CR; Hill, RG; Hughes, J; Hunter, JC; Sharif, NA | 1 |
| Clapham, JC; Wilson, C | 1 |
| Quast, U | 1 |
| Shetty, SS; Weiss, GB | 1 |
| Hamilton, TC; Weir, SW; Weston, AH | 1 |
| Hirata, Y; Kobayashi, J; Nakamura, H; Ohizumi, Y | 1 |
| Macmorine, DR; Movat, HZ; Takeuchi, Y | 1 |
| Franks, FM; Ison, RR; Soh, KS | 1 |
| Albuquerque, EX; Sansone, FM; Warnick, JE | 1 |
| Albuquerque, EX; Daly, J; Sansone, FM; Warnick, JE | 1 |
| Albuquerque, EX; Warnick, JE | 1 |
| Joshua, H; Shohat, B | 1 |
| Koppanyi, T; Osterberg, RE | 1 |
| Hester, JB; Rudzik, AD; Veldkamp, W | 1 |
4 trial(s) available for pyrroles and Muscle Contraction
| Article | Year |
|---|---|
Atorvastatin increases exercise leg blood flow in healthy adults.
Topics: Adult; Aged; Analysis of Variance; Atorvastatin; Blood Flow Velocity; Connecticut; Double-Blind Method; Drug Administration Schedule; Exercise; Female; Femoral Artery; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperemia; Lipids; Lower Extremity; Male; Middle Aged; Muscle Contraction; Placebos; Pyrroles; Regional Blood Flow; Time Factors; Ultrasonography, Doppler; Vasodilation | 2011 |
Effect of long-term atorvastatin treatment on the electrophysiological and mechanical functions of muscle.
Topics: Anticholesteremic Agents; Atorvastatin; Cholesterol; Dyslipidemias; Electromyography; Exercise; Female; Heptanoic Acids; Humans; Male; Middle Aged; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Pyrroles; Triglycerides | 2006 |
Zomepirac in the symptomatic treatment of muscle contraction headache.
Topics: Adult; Analgesics; Clinical Trials as Topic; Female; Headache; Humans; Male; Middle Aged; Muscle Contraction; Pyrroles; Tolmetin | 1980 |
A double-blind study of zomepirac sodium and placebo in the treatment of muscle contraction headache.
Topics: Adult; Analgesics; Clinical Trials as Topic; Double-Blind Method; Female; Headache; Humans; Male; Muscle Contraction; Pyrroles; Tolmetin | 1981 |
196 other study(ies) available for pyrroles and Muscle Contraction
| Article | Year |
|---|---|
Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416/hypoxia model of pulmonary hypertension.
Topics: Animals; Diaphragm; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Interleukin-1 Receptor-Like 1 Protein; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Mitochondrial Diseases; Muscle Contraction; Protein Kinase Inhibitors; Pulmonary Arterial Hypertension; Pyrroles | 2022 |
TRPV4 channels' dominant role in the temperature modulation of intrinsic contractility and lymph flow of rat diaphragmatic lymphatics.
Topics: Animals; Diaphragm; Female; In Vitro Techniques; Lymph; Lymphatic Vessels; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Periodicity; Pyrroles; Rats; Rats, Wistar; Ruthenium Red; Signal Transduction; Temperature; Time Factors; TRPV Cation Channels | 2020 |
Relaxing Effect of TSU-68, an Antiangiogenic Agent, on Mouse Airway Smooth Muscle.
Topics: Acetylcholine; Angiogenesis Inhibitors; Animals; Calcium; Calcium Channels; Cells, Cultured; Indoles; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle Relaxation; Myocytes, Smooth Muscle; Oxindoles; Patch-Clamp Techniques; Potassium; Propionates; Pyrroles | 2017 |
Epidermal growth factor receptor inhibitor PKI-166 governs cardiovascular protection without beneficial effects on the kidney in hypertensive 5/6 nephrectomized rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Blood Pressure; Cardiotonic Agents; ErbB Receptors; Hypertension, Renal; Immunohistochemistry; Kidney; Lisinopril; Male; Mesenteric Arteries; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nephrectomy; Proteinuria; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Adrenergic, alpha-1 | 2013 |
Atorvastatin administered before myocardial infarction in rats improves contractility irrespective of metabolic changes.
Topics: Animals; Atorvastatin; Echocardiography; Glucose Transporter Type 4; Heart Ventricles; Heptanoic Acids; Male; Muscle Contraction; Myocardial Infarction; Myocardium; Pyrroles; Rats; Rats, Inbred WKY; Ventricular Remodeling | 2014 |
Inhibition of 5-LOX, COX-1, and COX-2 increases tendon healing and reduces muscle fibrosis and lipid accumulation after rotator cuff repair.
Topics: Acetyl-CoA C-Acetyltransferase; Animals; Apoptosis Regulatory Proteins; Autophagy-Related Protein 5; Beclin-1; Biomechanical Phenomena; Carrier Proteins; Diacylglycerol O-Acyltransferase; Enzyme Inhibitors; Fibrocartilage; Fibrosis; Hydroxyproline; Interleukin-10; Intracellular Signaling Peptides and Proteins; Lipid Metabolism; Male; Muscle Contraction; Muscle Fibers, Fast-Twitch; Muscle Proteins; Muscle, Skeletal; Perilipin-1; Phosphoproteins; PPAR gamma; Proteins; Pyrroles; Rats, Sprague-Dawley; RNA, Messenger; Rotator Cuff; Vesicular Transport Proteins; Wound Healing | 2014 |
Functional coupling of TRPV4 channels and BK channels in regulating spontaneous contractions of the guinea pig urinary bladder.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Guinea Pigs; Indoles; Large-Conductance Calcium-Activated Potassium Channels; Male; Morpholines; Muscle Contraction; Nifedipine; Peptides; Potassium Channel Blockers; Pyrroles; TRPV Cation Channels; Urinary Bladder | 2016 |
Contractile actions of L-type Ca2+ agonists in human vas deferens and effects of structurally different Ca2+ antagonists.
Topics: Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Humans; In Vitro Techniques; Male; Muscle Contraction; Phenothiazines; Potassium; Pyrroles; Vas Deferens | 2010 |
Comparative effects of T-type and L-type Ca(2+)-antagonists against noradrenaline-induced contractions of human vas deferens.
Topics: Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Flunarizine; Humans; Male; Mibefradil; Muscle Contraction; Muscle, Smooth; Nifedipine; Norepinephrine; Pyrroles; Vas Deferens | 2010 |
Atorvastatin therapy during the peri-infarct period attenuates left ventricular dysfunction and remodeling after myocardial infarction.
Topics: Animals; Apoptosis; Atorvastatin; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxyproline; Muscle Contraction; Myocardial Infarction; Myocytes, Cardiac; Pyrroles; Rats; Rats, Inbred F344; Ventricular Dysfunction, Left; Ventricular Remodeling | 2011 |
Urocortin 1 inhibits guinea pig gallbladder contractility in vitro via corticotropin-releasing factor receptor 2.
Topics: Acetylcholine; Animals; DNA, Complementary; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Muscles; Peptide Fragments; Peptides, Cyclic; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Signal Transduction; Urocortins | 2011 |
Perspective on the role of P2X-purinoceptor activation in human vas deferens contractility.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Amides; Apamin; Calcium Channel Agonists; Calcium Channels, L-Type; Humans; Large-Conductance Calcium-Activated Potassium Channels; Male; Muscle Contraction; Norepinephrine; Peptides; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Purinergic P2X Receptor Agonists; Pyridines; Pyrophosphatases; Pyrroles; Receptors, Purinergic P2X; rho-Associated Kinases; Suramin; Vas Deferens | 2012 |
Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.
Topics: Animals; Caffeine; Calcium Channel Agonists; Calcium Signaling; Cell Hypoxia; Cells, Cultured; Dantrolene; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Macrocyclic Compounds; Male; Morpholines; Muscle Contraction; Muscle Relaxants, Central; Myocytes, Smooth Muscle; Oxazoles; Patch-Clamp Techniques; Phorbols; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Ryanodine; Ryanodine Receptor Calcium Release Channel; TRPV Cation Channels | 2012 |
Bio-inspired polymer composite actuator and generator driven by water gradients.
Topics: Biomimetics; Borates; Electric Power Supplies; Electricity; Ethylene Glycols; Muscle Contraction; Polymers; Propylene Glycols; Pyrroles; Water | 2013 |
CHEMICAL FACTORS AFFECTING SPONTANEOUS MOTILITY OF THE SMALL INTESTINE IN THE RAT. 1. SULFHYDRYL REACTANTS.
Topics: Acetylcholine; Anti-Bacterial Agents; Benzoates; Cadmium; Cysteine; Hydrogen Peroxide; Ileum; Intestine, Small; Iodides; Lead; Muscle Contraction; Muscle, Smooth; Nucleosides; Pharmacology; Pyrroles; Rats; Research; Zinc | 1964 |
RELATIONSHIP BETWEEN ATPASE ACTIVITY AND OPTICAL DENSITY DURING CONTRACTION AND RELAXATION OF MYOFIBRILS.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Biochemical Phenomena; Biochemistry; Calcium; Centrifugation; Chemical Phenomena; Chemistry, Physical; Edetic Acid; Ethylmaleimide; Hydrolysis; Ions; Magnesium; Muscle Contraction; Myofibrils; Oxalates; Potassium; Potassium Chloride; Pyrroles; Rabbits; Relaxation; Research | 1964 |
New evidence on the mechanisms underlying bradykinin-mediated contraction of the pig iris sphincter in vitro.
Topics: Animals; Benzamides; Bradykinin; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Calcium; Calcium Channels; Capsaicin; Carbazoles; Conotoxins; Dipeptides; Dose-Response Relationship, Drug; Egtazic Acid; In Vitro Techniques; Indoles; Iris; Maleimides; Muscle Contraction; Nicardipine; omega-Agatoxin IVA; Peptide Fragments; Piperidines; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Receptors, Calcitonin Gene-Related Peptide; Receptors, Drug; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Swine; Tachykinins | 2003 |
A novel pyrrole derivative, NS-8, suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity.
Topics: Animals; Calcium Channel Blockers; Female; Muscle Contraction; Neurons, Afferent; Parasympatholytics; Pelvis; Pyrroles; Rats; Reflex; Urinary Bladder; Urination; Urodynamics | 2003 |
Effects of TAK-802, a novel acetylcholinesterase inhibitor, and various cholinomimetics on the urodynamic characteristics in anesthetized guinea pigs.
Topics: Anesthesia; Anesthetics, Intravenous; Animals; Cholinergic Agents; Cholinesterase Inhibitors; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Pressure; Pyrroles; Quinolones; Urethane; Urethra; Urinary Bladder Neck Obstruction; Urodynamics | 2004 |
Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist.
Topics: Analgesics; Animals; Binding, Competitive; Buprenorphine; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Macaca mulatta; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Muscle Contraction; Pain; Pain Measurement; Pyrroles; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Time Factors; Tritium; Vas Deferens | 2004 |
Novel acetylcholinesterase inhibitor as increasing agent on rhythmic bladder contractions: SAR of 8-{3-[1-(3-fluorobenzyl)piperidin-4-yl]propanoyl}-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (TAK-802) and related compounds.
Topics: Acetylcholinesterase; Animals; Bethanechol; Cholinesterase Inhibitors; Guinea Pigs; Inhibitory Concentration 50; Male; Molecular Structure; Muscle Contraction; Pyrroles; Quinolones; Rats; Structure-Activity Relationship; Urinary Bladder | 2005 |
Corticosterone implants to the amygdala and type 1 CRH receptor regulation: effects on behavior and colonic sensitivity.
Topics: Amygdala; Animals; Behavior, Animal; Colon; Corticosterone; Drug Delivery Systems; Drug Interactions; Male; Maze Learning; Muscle Contraction; Pempidine; Pyrimidines; Pyrroles; Radioimmunoassay; Rats; Rats, Inbred F344; Receptors, Corticotropin-Releasing Hormone; Stress, Psychological; Time Factors | 2005 |
Peripheral injection of sauvagine prevents repeated colorectal distension-induced visceral pain in female rats.
Topics: Abdominal Pain; Amphibian Proteins; Animals; Colon; Dilatation, Pathologic; Female; Injections, Subcutaneous; Muscle Contraction; Peptide Hormones; Peptides; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Rectum | 2005 |
Chronic CO levels have [corrected] a beneficial effect on vascular relaxation in diabetes.
Topics: Acetylcholine; Animals; Aorta; Biliverdine; Blotting, Western; Carbon Monoxide; Chromium; Densitometry; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelium, Vascular; Femoral Artery; Guanylate Cyclase; Heme; Immunohistochemistry; Male; Mesoporphyrins; Muscle Contraction; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organometallic Compounds; Oxadiazoles; Oxidative Stress; Protoporphyrins; Pyrazines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Time Factors | 2006 |
Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists.
Topics: Amides; Animals; Benzamides; Bradycardia; Brain; Dogs; Esophagus; Esters; Female; Gastric Emptying; Guinea Pigs; Imidazoles; In Vitro Techniques; Indoles; Male; Mice; Muscle Contraction; Muscle, Smooth; Pyloric Antrum; Pyrroles; Pyrrolizidine Alkaloids; Radioligand Assay; Rats; Rats, Wistar; Serotonin 5-HT4 Receptor Agonists; Serotonin 5-HT4 Receptor Antagonists; Structure-Activity Relationship | 2006 |
Effects of chronic treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and electrophysiological study.
Topics: Action Potentials; Animals; Aquaporin 4; Atorvastatin; Body Weight; Chloride Channels; Dose-Response Relationship, Drug; Eating; Fatty Acids, Monounsaturated; Fenofibrate; Fluvastatin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Indoles; Kidney Diseases; Lipids; Male; Membrane Potentials; Muscle Contraction; Muscle Fibers, Fast-Twitch; Muscle, Skeletal; Muscular Diseases; Myosin Heavy Chains; Organ Size; Pyrroles; Rats; Rats, Wistar; Rhabdomyolysis; Time Factors | 2006 |
New procedure to mask the 2,3-pi bond of the indole nucleus and its application to the preparation of potent opioid receptor agonists with a Corynanthe skeleton.
Topics: Alkaloids; Animals; Ethylene Glycol; Guinea Pigs; Ileum; In Vitro Techniques; Indicators and Reagents; Indole Alkaloids; Indoles; Iodine; Mitragyna; Muscle Contraction; Muscle, Smooth; Pausinystalia; Pyrroles; Receptors, Opioid | 2006 |
Attenuation of contractile dysfunction by atorvastatin after intestinal ischemia reperfusion injury in rats.
Topics: Administration, Oral; Animals; Atorvastatin; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Glutathione; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ileum; In Vitro Techniques; Intestines; Male; Malondialdehyde; Muscle Contraction; Neurotransmitter Agents; Peroxidase; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Reperfusion Injury; Substance P | 2007 |
Work behaviors of artificial muscle based on cation driven polypyrrole.
Topics: Biomimetic Materials; Biomimetics; Cations; Elasticity; Electrochemistry; Energy Transfer; Equipment Design; Equipment Failure Analysis; Muscle Contraction; Muscle, Skeletal; Polymers; Pyrroles; Stress, Mechanical | 2007 |
Drug-screening platform based on the contractility of tissue-engineered muscle.
Topics: Animals; Atorvastatin; Biological Assay; Cells, Cultured; Drug Evaluation, Preclinical; Electric Stimulation; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin-Like Growth Factor I; Male; Mice; Mice, Inbred C3H; Muscle Contraction; Muscular Atrophy; Myoblasts; Pyrroles; Tissue Engineering | 2008 |
Allosteric interactions at L-type calcium channels between FPL 64176 and the enantiomers of the dihydropyridine Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Allosteric Regulation; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Pyrroles; Stereoisomerism | 1995 |
Potassium channel inhibitors attenuate neuromodulatory effects of atrial natriuretic factor in the rabbit isolated vas deferens.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Atrial Natriuretic Factor; Benzopyrans; Charybdotoxin; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Potassium Channel Blockers; Potassium Channels; Prazosin; Pyrroles; Rabbits; Receptors, Adrenergic; Scorpion Venoms; Synaptic Transmission; Tetraethylammonium; Tetraethylammonium Compounds; Vas Deferens | 1994 |
Pharmacologic profiles of YM934, a novel potassium channel opener.
Topics: Anesthesia; Animals; Aorta; Benzopyrans; Benzoxazines; Cromakalim; Cyclic N-Oxides; Dogs; Female; Hemodynamics; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Oxazines; Portal Vein; Potassium Channels; Pyrroles; Rabbits; Rats; Rats, Wistar; Vascular Resistance; Vasodilation | 1994 |
Vasodilating actions of cromakalim in resting and contracting states of carotid arteries from spontaneously hypertensive rats.
Topics: Animals; Benzopyrans; Carotid Arteries; Charybdotoxin; Cromakalim; Drug Interactions; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Scorpion Venoms; Species Specificity; Vasodilator Agents | 1994 |
Functional evidence for a glibenclamide-sensitive K+ channel in rat ileal smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Carbachol; Cromakalim; Glyburide; Ileum; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Rats; Rats, Wistar | 1994 |
Propagation of impulses in the guinea-pig ureter and its blockade by calcitonin gene-related peptide (CGRP).
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Pyrroles; Tetrodotoxin; Ureter | 1995 |
Response of guinea pig smooth and striated urethral sphincter to cromakalim, prazosin, nifedipine, nitroprusside, and electrical stimulation.
Topics: Amino Acid Oxidoreductases; Animals; Antihypertensive Agents; Benzopyrans; Calcium; Calmodulin-Binding Proteins; Cromakalim; Decamethonium Compounds; Electric Stimulation; Guinea Pigs; Hexamethonium; Histocytochemistry; Male; Muscle Contraction; Muscle Relaxation; Muscle, Skeletal; Muscle, Smooth; Nifedipine; Nitric Oxide Synthase; Nitroprusside; Prazosin; Pyrroles; Urethra | 1995 |
Inhibition by cromakalim, pinacidil, terbutaline, theophylline and verapamil of non-cholinergic nerve-mediated contractions of guinea-pig isolated bronchi.
Topics: Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Pinacidil; Potassium Channels; Pyrroles; Substance P; Synaptic Transmission; Terbutaline; Theophylline; Verapamil | 1994 |
Pharmacological characterization of a new class of nonpeptide neurokinin A antagonists that demonstrate species selectivity.
Topics: Animals; Cell Line; Cricetinae; Guinea Pigs; Humans; In Vitro Techniques; Lung; Muscle Contraction; Muscle, Smooth; Protein Binding; Pyrimidines; Pyrroles; Receptors, Neurokinin-2; Species Specificity; Trachea; Tumor Cells, Cultured | 1995 |
The effects of glibenclamide on tetanic force and intracellular calcium in normal and fatigued mouse skeletal muscle.
Topics: Acidosis; Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Electric Stimulation; Glyburide; Intracellular Membranes; Male; Mice; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Potassium Channel Blockers; Potassium Channels; Pyrroles; Reference Values | 1995 |
Pharmacological natures of caffeine-induced endothelium-dependent and -independent contraction in canine mesenteric artery.
Topics: Adenylyl Cyclases; Animals; Benzopyrans; Caffeine; Calcium; Calcium Channel Blockers; Colforsin; Cromakalim; Dogs; Edetic Acid; Egtazic Acid; Endothelium, Vascular; Female; In Vitro Techniques; Magnesium; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1995 |
Functional study on the effects of nifedipine, cromakalim, and the absence of extracellular Ca2+ on alpha 1-adrenoceptor-mediated excitation-contraction coupling in isolated rat portal vein: comparison with depolarization-mediated excitation-contraction c
Topics: Animals; Benzopyrans; Calcium; Calcium Channel Blockers; Cromakalim; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Parasympatholytics; Phenylephrine; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Receptors, Adrenergic, alpha | 1993 |
Cromakalim inhibits multiple mechanisms of smooth muscle activation with similar stereoselectivity.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium; Cromakalim; Glyburide; In Vitro Techniques; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Neuromuscular Depolarizing Agents; Norepinephrine; Potassium Chloride; Pyrroles; Rabbits; Stereoisomerism; Vasodilator Agents | 1993 |
Distinct pathways to refill ACh-sensitive internal Ca2+ stores in canine airway smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Benzopyrans; Calcium; Cromakalim; Dogs; Female; Indoles; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Pyrroles; Trachea | 1993 |
Effects of cromakalim on bradykinin-, histamine- and substance P-induced airway microvascular leakage in the guinea-pig.
Topics: Animals; Benzopyrans; Bradykinin; Bronchi; Capillary Permeability; Cromakalim; Electric Stimulation; Evans Blue; Female; Guinea Pigs; Histamine; In Vitro Techniques; Injections, Intravenous; Lung; Male; Muscle Contraction; Muscle, Smooth; Pyrroles; Respiratory System; Substance P; Trachea | 1993 |
A simple method for measurement of ureteric peristaltic function in vivo and the effects of drugs acting on ion channels applied from the ureter lumen in anesthetized rats.
Topics: 4-Aminopyridine; Anesthesia; Animals; Benzopyrans; Cromakalim; Glyburide; Ion Channels; Lidocaine; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Pyrroles; Rats; Rats, Sprague-Dawley; Ureter; Vasodilator Agents | 1993 |
General pharmacology of [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3- dihydro-1H-pyrrolizine-5-yl]-acetic acid in experimental animals.
Topics: Acetates; Animals; Behavior, Animal; Cats; Central Nervous System; Digestive System; Dogs; Female; Guinea Pigs; Hemodynamics; Kidney; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Skeletal; Muscle, Smooth; Pyrroles; Rats; Rats, Wistar; Respiratory System | 1995 |
Mechanical and electrophysiological effects of cromakalim on the human urinary bladder.
Topics: Adult; Benzopyrans; Cromakalim; Electrophysiology; Female; Humans; Male; Membrane Potentials; Middle Aged; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Potassium Channels; Pyrroles; Stress, Mechanical; Urinary Bladder | 1994 |
Cardioprotective profile of the cardiac-selective ATP-sensitive potassium channel opener BMS-180448.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Aorta; Benzopyrans; Cromakalim; Decanoic Acids; Dogs; Female; Glyburide; Guanidines; Guinea Pigs; Heart; Heart Ventricles; Hydroxy Acids; In Vitro Techniques; Injections, Intravenous; Injections, Subcutaneous; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Ischemia; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1995 |
The inhibitory mechanisms of nicorandil in isolated rat urinary bladder and femoral artery.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Cyclic GMP; Electric Stimulation; Femoral Artery; Guanylate Cyclase; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Urinary Bladder; Vasodilator Agents | 1995 |
Effects of potassium channel activators on isolated cerebral arteries of large and small diameter in the cat.
Topics: Animals; Benzopyrans; Cats; Cerebral Arteries; Cromakalim; Dihydropyridines; Dose-Response Relationship, Drug; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Uridine Triphosphate; Vasodilator Agents | 1995 |
Differential effects of pinacidil and cromakalim on vascular relaxation and sympathetic neurotransmission.
Topics: Animals; Benzopyrans; Cattle; Cromakalim; Dogs; Electric Stimulation; Female; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Pinacidil; Potassium Chloride; Pyrroles; Sympathetic Nervous System; Synaptic Transmission; Vasodilator Agents | 1994 |
Multiple mechanisms in the smooth muscle relaxant action of calcitonin gene-related peptide (CGRP) in the guinea-pig ureter.
Topics: Action Potentials; Animals; Arginine; Benzopyrans; Calcitonin Gene-Related Peptide; Colforsin; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Nitroarginine; Parasympatholytics; Pyrroles; Ureter | 1994 |
The effects of a novel vasodilator, LP-805, on cytosolic Ca2+ concentrations and on tension in rabbit isolated femoral arteries.
Topics: Animals; Arginine; Benzopyrans; Calcium; Cromakalim; Cytosol; Endothelium, Vascular; Femoral Artery; Fura-2; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Norepinephrine; Potassium; Pyrazoles; Pyrimidines; Pyrroles; Rabbits; Vasodilator Agents | 1994 |
Mechanical and electrophysiological effects of cromakalim on the human urinary bladder.
Topics: Animals; Benzopyrans; Cromakalim; Female; Guinea Pigs; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Rats; Urinary Bladder | 1994 |
Mechanisms of vasorelaxation induced by N-allylsecoboldine in rat thoracic aorta.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Aorta, Thoracic; Aporphines; Benzopyrans; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphatidylinositols; Potassium; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents; Verapamil | 1994 |
Effect of cromakalim and glibenclamide on spontaneous and evoked motility of the guinea-pig isolated renal pelvis and ureter.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guinea Pigs; In Vitro Techniques; Kidney Pelvis; Male; Membrane Potentials; Muscle Contraction; Potassium Channels; Pyrroles; Ureter | 1994 |
The effects of racemic cromakalim, BRL 38226 and levcromakalim on the membrane potential of the rat aorta and of BRL 38226 on the contractile activity of the rat aorta and portal vein.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Isoproterenol; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Stereoisomerism; Vasoconstrictor Agents | 1994 |
Levcromakalim-induced modulation of membrane potassium currents, intracellular calcium and mechanical activity in rat mesenteric artery.
Topics: Animals; Arterioles; Benzopyrans; Calcium; Cell Membrane; Cromakalim; Electrophysiology; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Beta-adrenoceptor subtypes and the opening of plasmalemmal K(+)-channels in trachealis muscle: electrophysiological and mechanical studies in guinea-pig tissue.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Animals; Benzopyrans; Cell Membrane; Cromakalim; Electrophysiology; Female; Guinea Pigs; Heart; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Myocardium; Norepinephrine; Potassium Channels; Procaterol; Propanolamines; Pyrroles; Receptors, Adrenergic, beta; Rubidium Radioisotopes; Salmeterol Xinafoate; Trachea | 1993 |
Cromakalim does not protect against skeletal muscle fatigue in an anaesthetized rat model of acute hindlimb ischaemia.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Heart Rate; Hindlimb; Ischemia; Male; Muscle Contraction; Muscles; Pyrroles; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Vasodilator Agents | 1993 |
Effects of K-channel openers on the contractility and electrical activity of antral circular muscle in guinea-pig stomach.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Muscle Contraction; Muscle, Smooth; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Stomach | 1993 |
Partial inhibition by epithelium of tracheal smooth muscle relaxation induced by the potassium channel activator, BRL 38227.
Topics: Aminophylline; Animals; Benzopyrans; Biotransformation; Bronchodilator Agents; Carbachol; Cromakalim; Epithelium; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Trachea | 1993 |
Effects of three K+ channel openers on airways and pulmonary circulation in the isolated guinea-pig lung.
Topics: Animals; Benzopyrans; Bronchoconstriction; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle, Smooth, Vascular; Picolines; Pinacidil; Potassium; Potassium Channels; Pulmonary Circulation; Pyrans; Pyrroles | 1993 |
ATP-sensitive potassium channels and skeletal muscle function in vitro.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; Energy Metabolism; Gallamine Triethiodide; Glyburide; Guanidines; In Vitro Techniques; Ischemia; Male; Muscle Contraction; Muscles; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley | 1993 |
Vasodilator action of cromakalim on human mesenteric artery.
Topics: Aged; Aged, 80 and over; Benzopyrans; Cromakalim; Humans; In Vitro Techniques; Mesenteric Arteries; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Chloride; Pyrroles; Vasodilation; Vasodilator Agents | 1993 |
Effects of the novel potassium channel opener, UR-8225, on contractile responses in rat isolated smooth muscle.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Calcium; Cromakalim; Female; In Vitro Techniques; Ion Channel Gating; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Norepinephrine; Portal Vein; Potassium Channels; Potassium Chloride; Pyridones; Pyrroles; Rats; Rats, Sprague-Dawley; Rubidium; Rubidium Radioisotopes; Vasodilator Agents | 1993 |
Effects of KC 399, a novel ATP-sensitive K+ channel opener, on electrical and mechanical responses in dog tracheal smooth muscle.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Carbachol; Cromakalim; Cyclic AMP; Cyclic GMP; Dogs; Female; Glyburide; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Trachea | 1994 |
Actions of potassium channel openers in rat detrusor urinae.
Topics: Animals; Benzopyrans; Cromakalim; Guanidines; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Picolines; Potassium Channels; Pyrans; Pyrroles; Rats; Rats, Sprague-Dawley; Urinary Bladder | 1993 |
SC-49518 enhances gastric emptying of solid and liquid meals and stimulates gastrointestinal motility in dogs by a 5-hydroxytryptamine4 receptor mechanism.
Topics: Animals; Antiemetics; Benzamides; Dogs; Electrodes; Esophagus; Female; Food; Gastric Emptying; Gastrointestinal Motility; Guinea Pigs; In Vitro Techniques; Intestines; Male; Models, Biological; Motor Activity; Muscle Contraction; Pyloric Antrum; Pyrroles; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Stimulation, Chemical | 1993 |
SC-53606, a potent and selective antagonist of 5-hydroxytryptamine4 receptors in isolated rat esophageal tunica muscularis mucosae.
Topics: 4-Aminobenzoic Acid; Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Esophagus; Imidazoles; In Vitro Techniques; Indoles; Male; Mucous Membrane; Muscle Contraction; Muscle, Smooth; para-Aminobenzoates; Pyrroles; Rats; Receptors, Cell Surface; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tropisetron; Tryptamines | 1993 |
Effects of cromakalim on the electrical slow wave in the circular muscle of guinea-pig gastric antrum.
Topics: Animals; Benzopyrans; Cromakalim; Electrophysiology; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Potassium; Pyloric Antrum; Pyrroles; Sodium | 1993 |
The inhibitory effects of Ro 31-6930 and BRL 38227 on cholinergically-mediated bronchoconstriction in the guinea-pig.
Topics: Acetylcholine; Animals; Benzopyrans; Bronchoconstriction; Bronchodilator Agents; Cromakalim; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyridines; Pyrroles; Trachea; Vagus Nerve | 1993 |
Effect of cromakalim on KCl-, noradrenaline- and angiotensin II-induced contractions in the rat pulmonary artery.
Topics: Angiotensin II; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Glyburide; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phentolamine; Potassium Chloride; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Tetraethylammonium Compounds | 1993 |
Inhibitory effect of cromakalim in human detrusor muscle is mediated by glibenclamide-sensitive potassium channels.
Topics: Benzopyrans; Cromakalim; Depression, Chemical; Dose-Response Relationship, Drug; Glyburide; Humans; In Vitro Techniques; Male; Muscle Contraction; Potassium Channels; Pyrroles; Urinary Bladder | 1993 |
The effect of cromakalim on the electrical properties of and [86Rb+] efflux from normal and hypertrophied rat bladder.
Topics: Action Potentials; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Electrophysiology; Female; Hypertrophy; In Vitro Techniques; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle, Smooth; Nifedipine; Parasympatholytics; Pyrroles; Rats; Rats, Sprague-Dawley; Rubidium; Rubidium Radioisotopes; Urinary Bladder | 1993 |
The individual enantiomers of cis-cromakalim possess K+ channel opening activity.
Topics: Anesthesia; Animals; Aorta, Thoracic; Benzopyrans; Binding, Competitive; Blood Pressure; Cromakalim; Endothelium, Vascular; Guanidines; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Wistar; Rubidium Radioisotopes; Stereoisomerism; Vasodilation; Vasodilator Agents | 1993 |
Relaxation of subarachnoid hemorrhage-induced spasm of rabbit basilar artery by the K+ channel activator cromakalim.
Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; In Vitro Techniques; Ischemic Attack, Transient; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Potassium; Potassium Channels; Pyrroles; Rabbits; Subarachnoid Hemorrhage; Time Factors; Vasodilator Agents | 1996 |
Effects of potassium channel modulators cromakalim, tetraethylammonium and glibenclamide on the contractility of the isolated human ureter.
Topics: Benzopyrans; Cromakalim; Glyburide; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Channels; Potassium Chloride; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds; Ureter | 1996 |
The effects of pharmacological modulation of KATP on the guinea-pig isolated diaphragm.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diaphragm; Electrophysiology; Glyburide; Guanidines; Guinea Pigs; Indoles; Male; Membrane Potentials; Muscle Contraction; Muscle Tonus; Phentolamine; Pinacidil; Potassium Channels; Pyrroles | 1996 |
Effects of chronic oral administration of levcromakalim on in vitro contractile responses of arterial smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Calcium Channel Blockers; Cromakalim; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitroprusside; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Rats, Wistar; Vasodilator Agents; Verapamil | 1996 |
Comparative effects of intravesical versus extravesical administration of ZD6169 and cromakalim on the response of the in vitro rat whole bladder to field stimulation.
Topics: Amides; Animals; Benzophenones; Benzopyrans; Cromakalim; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Urinary Bladder | 1996 |
Pharmacodynamic behaviour of isolated resistance vessels obtained from hypertensive-diabetic rats.
Topics: Animals; Benzopyrans; Blood Glucose; Calcium Channels; Calcium Chloride; Cromakalim; Glyburide; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; Methacholine Chloride; Methoxamine; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitroprusside; Norepinephrine; Obesity; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Zucker; Serotonin; Tunica Media; Vascular Resistance; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Effects of SCA40 on human bronchi and on guinea pig main bronchi in vitro. Comparison with cromakalim.
Topics: Acetylcholine; Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Capsaicin; Charybdotoxin; Cromakalim; Electric Stimulation; Female; Glyburide; Guinea Pigs; Humans; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurokinin A; Nitroprusside; Osmolar Concentration; Parasympatholytics; Potassium Channel Blockers; Potassium Channels; Pyrazines; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds | 1996 |
Possible mechanism of the potent vasoconstrictor responses to ryanodine in dog cerebral arteries.
Topics: Animals; Benzopyrans; Caffeine; Calcium; Calcium Channel Blockers; Cerebral Arteries; Cromakalim; Dogs; Female; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nifedipine; Phosphodiesterase Inhibitors; Potassium; Pyrroles; Ryanodine; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Changes in sensitivity of 5-HT receptor mediated functional responses in the rat oesophagus, fundus and jejunum following chronic infusion with 5-hydroxytryptamine.
Topics: Animals; Benzamides; Esophagus; Gastric Mucosa; Infusions, Intravenous; Jejunum; Male; Muscle Contraction; Muscle, Smooth; Piperazines; Pyrroles; Rats; Serotonin; Serotonin Receptor Agonists; Stomach | 1996 |
Potassium channel modulation: a new drug principle for regulation of smooth muscle contractility. Studies on isolated airways and arteries.
Topics: Animals; Arteries; Asthma; Benzopyrans; Bronchi; Cardiovascular Diseases; Cromakalim; Female; Guinea Pigs; Humans; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Sulfonylurea Compounds; Synaptic Transmission; Trachea; Vasodilator Agents | 1996 |
Relaxant effect of levcromakalim in isolated human small subcutaneous arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Adolescent; Adult; Arteries; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Drug Interactions; Female; Glyburide; Humans; In Vitro Techniques; Methacholine Chloride; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Skin; Thromboxane A2; Vasoconstrictor Agents | 1995 |
Involvement of K+ channels in the relaxant effect of vasoactive intestinal peptide and atrial natriuretic peptide in isolated guinea-pig trachea.
Topics: Adenosine Triphosphate; Animals; Atrial Natriuretic Factor; Benzopyrans; Calcium Channel Blockers; Cromakalim; Guinea Pigs; In Vitro Techniques; Isradipine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Trachea; Vasoactive Intestinal Peptide | 1997 |
Novel effects of guanidine on the neuromuscular junction.
Topics: 4-Aminopyridine; Animals; Benzopyrans; Calcium; Chickens; Cromakalim; Electric Stimulation; Electromyography; Evoked Potentials, Motor; Guanidine; Guanidines; In Vitro Techniques; Male; Mice; Muscle Contraction; Neuromuscular Junction; Potassium Channels; Pyrroles | 1997 |
Effects of putative K+ channel blockers on beta-adrenoceptor-mediated vasorelaxation of rat mesenteric artery.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Barium; Benzopyrans; Calcium; Charybdotoxin; Colforsin; Cromakalim; Cyclic AMP; Dose-Response Relationship, Drug; Fenoterol; Glyburide; Isoproterenol; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Potassium Channel Blockers; Pyrroles; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
The effect of cromakalim on intracellular [Ca2+] in isolated rat skeletal muscle during fatigue and metabolic blockade.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Cyanides; In Vitro Techniques; Intracellular Fluid; Iodoacetates; Iodoacetic Acid; Male; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Osmolar Concentration; Potassium Channels; Pyrroles; Rats; Rats, Wistar | 1997 |
Effects of JTV-506, a new K+ channel activator, on airway smooth muscle contraction and systemic blood pressure.
Topics: Animals; Benzopyrans; Blood Pressure; Bronchodilator Agents; Chromans; Cromakalim; Guinea Pigs; Histamine; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Trachea | 1997 |
Capacitative Ca2+ entry associated with alpha1-adrenoceptors in rat aorta.
Topics: Animals; Aorta; Benzopyrans; Calcium; Calcium Channel Blockers; Calcium Channels; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Tonus; Nimodipine; Norepinephrine; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Tetraethylammonium Compounds | 1997 |
Heterogeneity in the vasorelaxing effect of nicorandil on dog epicardial coronary arteries: comparison with other NO donors.
Topics: Animals; Atrial Natriuretic Factor; Benzopyrans; Coronary Vessels; Cromakalim; Cyclic GMP; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxyhemoglobins; Pyrroles; Vasodilator Agents | 1997 |
Influence of cytochrome P-450 inhibitors on endothelium-dependent nitro-L-arginine-resistant relaxation and cromakalim-induced relaxation in rat mesenteric arteries.
Topics: Acetylcholine; Animals; Benzopyrans; Biological Factors; Cromakalim; Cytochrome P-450 Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; In Vitro Techniques; Mesenteric Arteries; Miconazole; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Proadifen; Pyrroles; Rats; Rats, Wistar; Triazoles; Vasodilator Agents | 1997 |
Possible involvement of ATP-dependent K-channel related mechanisms in the antihypertensive and cough suppressant effects of the novel ACE inhibitor (2S, 3aS, 7aS)-1-(N2-nicotinoyl-L-lysyl-gamma-D-glutamyl)octahydro-1H- indole-2-carboxylic acid.
Topics: Adenosine Triphosphate; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Antitussive Agents; Aorta, Thoracic; Benzopyrans; Blood Pressure; Cromakalim; Dipeptides; Glyburide; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar | 1997 |
The comparison of the responsiveness of human isolated internal mammary and gastroepiploic arteries to levcromakalim: an alternative approach to the management of graft spasm.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arteries; Benzopyrans; Coronary Artery Bypass; Cromakalim; Endothelin-1; Female; Glyburide; Humans; In Vitro Techniques; Indomethacin; Male; Mammary Arteries; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Omentum; Potassium; Potassium Channel Blockers; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Stomach; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
Cardiovascular pharmacology of SKP-450, a new potassium channel activator, and its major metabolites SKP-818 and SKP-310.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Coronary Circulation; Cromakalim; Dogs; Dose-Response Relationship, Drug; Hemodynamics; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Pyrroles; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Vasodilation; Vasodilator Agents | 1998 |
Novel adrenoceptor antagonists with a tricyclic pyrrolodipyridazine skeleton.
Topics: Adrenergic Antagonists; Animals; Aorta, Thoracic; CHO Cells; Cricetinae; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Pyridazines; Pyrroles; Radioligand Assay; Receptors, Adrenergic, alpha-1; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Structure-Activity Relationship; Vas Deferens | 1999 |
Differential effects of pravastatin, simvastatin, and atorvastatin on Ca2+ release and vascular reactivity.
Topics: Animals; Anticholesteremic Agents; Aorta; Atorvastatin; Calcium; Cells, Cultured; Chelating Agents; Dose-Response Relationship, Drug; Drug Interactions; Fura-2; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Male; Mevalonic Acid; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Pravastatin; Pyrroles; Rats; Rats, Sprague-Dawley; Simvastatin; Vasoconstrictor Agents | 1999 |
Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Aorta; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Pyrroles; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Thionucleotides; Time Factors; Transfection; Tumor Necrosis Factor-alpha | 1999 |
NK(2)-receptor mediated contraction in monkey, guinea-pig and human airway smooth muscle.
Topics: Animals; Benzamides; Bronchi; Bronchoconstriction; Cryopreservation; Female; Guinea Pigs; Humans; Indoles; Macaca fascicularis; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Piperidines; Pyrroles; Pyrrolidines; Receptors, Neurokinin-2; Species Specificity | 1999 |
Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro.
Topics: Acetylcholine; Action Potentials; Animals; Anthraquinones; Atrial Function; Biguanides; Binding, Competitive; Colon; Dinoprostone; Dose-Response Relationship, Drug; Guinea Pigs; Heart Atria; Humans; In Vitro Techniques; Muscle Contraction; Myocardial Contraction; Pyrroles; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Receptor Agonists; Thiazoles | 2000 |
Involvement of anion exchange in the hypoxia/reoxygenation-induced changes in pH(i) and.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anions; Bicarbonates; Calcium; Carbazoles; Cells, Cultured; Chlorides; Electric Stimulation; Enzyme Inhibitors; Heart Ventricles; Hydrogen-Ion Concentration; In Vitro Techniques; Indoles; Ion Transport; Male; Muscle Contraction; Naphthalenes; Oxygen; Papillary Muscles; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley | 2001 |
Synthesis and 5-HT2A antagonist activity of derivatives of the novel heterocycles indolo[3,2-d]pyrrolo[3,2-g]azecine and benzo[d]pyrrolo[3,2-g]azecine compared to the benz[d]indolo[2,3-g]azecine derivative LE 300.
Topics: Animals; Binding, Competitive; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth, Vascular; Pyrroles; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin Antagonists | 2001 |
Effects of dexamethasone and protein kinase C inhibitors on the induction of bradykinin B1 mRNA and the bradykinin B1 receptor-mediated contractile response in isolated rat ileum.
Topics: Animals; Bradykinin; Cycloheximide; Dactinomycin; Dexamethasone; Ileum; Indoles; Interleukin-1; Isotonic Solutions; Lipopolysaccharides; Male; Muscle Contraction; Polymyxin B; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B1; Receptors, Bradykinin; RNA, Messenger; Temperature; Time Factors | 2002 |
The effect of the selective 5-HT(3) receptor agonist on ferret gut motility.
Topics: Animals; Benzimidazoles; Colon; Defecation; Ferrets; Gastrointestinal Motility; Male; Muscle Contraction; Pyrroles; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles | 2002 |
The 'mauve factor' of schizophrenia and porphyria, 5-hydroxyhaemopyrrole lactam, has low pharmacological potency on guinea-pig ileum.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Humans; Ileum; Muscle Contraction; Porphyrias; Pyrroles; Rats; Schizophrenia | 1979 |
Symptomatic treatment of tension headache.
Topics: Analgesics; Headache; Humans; Muscle Contraction; Pyrroles; Tolmetin | 1979 |
Pharmacological properties of kryptopyrrole and its oxidation products on isolated sciatic nerve of rat and on guinea-pig ileum.
Topics: Acetylcholine; Action Potentials; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Oxidation-Reduction; Pyrroles; Rats; Sciatic Nerve | 1979 |
The pharmacological properties of the cholinergic false transmitter, N-2-acetoxyethyl-N-methylpyrrolidinium, and its precursor, N-2-hydroxyethyl-N-methylpyrrolidinium.
Topics: Acetylcholine; Animals; Anura; Blood Pressure; Choline; Dose-Response Relationship, Drug; Guinea Pigs; Heart; Ileum; Leeches; Muscle Contraction; Muscles; Peripheral Nerves; Pyrroles; Pyrrolidines; Rats; Receptors, Cholinergic | 1977 |
Experimental antiulcer drugs. 2. 2-Substituted 2,4,5,6-tetrahydro-1,3,4,6,6-pentamethylcyclopenta[c]pyrrole-4-carboxamides.
Topics: Animals; Anti-Ulcer Agents; Depression, Chemical; Dogs; Gastric Juice; Guinea Pigs; Heart Rate; In Vitro Techniques; Mice; Muscle Contraction; Muscle, Smooth; Pyrroles; Rats; Structure-Activity Relationship | 1977 |
Role of K+ channels in the modulation of cholinergic neural responses in guinea-pig and human airways.
Topics: Adolescent; Adult; Animals; Benzopyrans; Charybdotoxin; Cholinergic Fibers; Clonidine; Cromakalim; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Humans; Male; Muscle Contraction; Neuropeptide Y; Potassium Channels; Pyrroles; Scorpion Venoms; Synaptic Transmission; Trachea | 1992 |
Potassium channel openers, NIP-121 and cromakalim, enhance the relaxation induced by sodium nitroprusside in the guinea-pig isolated trachea.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Drug Interactions; Epithelium; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitroprusside; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles; SRS-A; Trachea; Vasodilator Agents | 1992 |
Vasodilatation of canine cerebral arteries by nicorandil, pinacidil and lemakalim.
Topics: Animals; Basilar Artery; Benzopyrans; Cerebral Arteries; Cromakalim; Dogs; Female; Glyburide; Guanidines; Guanylate Cyclase; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Effect of cromakalim on the smooth muscle of the cat gastric antrum.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cats; Cromakalim; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Potassium Channels; Pyloric Antrum; Pyrroles | 1992 |
Effects of cromakalim on the contraction and the membrane potential of the circular smooth muscle of guinea-pig stomach.
Topics: Acetylcholine; Animals; Benzopyrans; Charybdotoxin; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Pyrroles; Scorpion Venoms; Stomach | 1992 |
Vasorelaxing effect in rat thoracic aorta caused by fraxinellone and dictamine isolated from the Chinese herb Dictamnus dasycarpus Turcz: comparison with cromakalim and Ca2+ channel blockers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Aorta, Thoracic; Benzofurans; Benzopyrans; Calcium; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Drugs, Chinese Herbal; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Quinolines; Rats; Rats, Inbred Strains; Verapamil | 1992 |
The role of cyclic AMP in non-adrenergic non-cholinergic contraction in guinea-pig bronchi.
Topics: Animals; Autonomic Nervous System; Benzopyrans; Bronchi; Bronchodilator Agents; Bucladesine; Colforsin; Cromakalim; Cyclic AMP; Electric Stimulation; Ethanolamines; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurons, Afferent; Nitroprusside; Procaterol; Pyrroles; Substance P; Theophylline | 1992 |
Excitation-contraction coupling in canine tracheal smooth muscle cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Benzopyrans; Calcium; Calcium Channels; Cromakalim; Dogs; Egtazic Acid; In Vitro Techniques; Models, Biological; Muscle Contraction; Muscle, Smooth; Nifedipine; Parasympatholytics; Pyrroles; Sarcoplasmic Reticulum; Tetraethylammonium; Tetraethylammonium Compounds; Trachea | 1992 |
Effects of K+ channel blockers on the relaxant action of dihydralazine, cromakalim and nitroprusside in isolated rabbit femoral arteries.
Topics: Animals; Benzopyrans; Cromakalim; Dihydralazine; Endothelium, Vascular; Female; Femoral Artery; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Norepinephrine; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1992 |
Effects of imidazoline-related compounds on the mechanical response to nicorandil in the rat portal vein.
Topics: Animals; Benzopyrans; Cromakalim; Imidazoles; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Portal Vein; Potassium Channels; Pyrroles; Rats; Rats, Wistar | 1992 |
Activation of phospholipase C by the agonist U46619 is inhibited by cromakalim-induced hyperpolarization in porcine coronary artery.
Topics: Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Enzyme Activation; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Membrane Potentials; Muscle Contraction; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Swine; Thromboxane A2; Type C Phospholipases | 1992 |
On the pharmacological and physiological role of glibenclamide-sensitive potassium channels in colonic smooth muscle.
Topics: Animals; Benzopyrans; Carbachol; Colforsin; Colon; Cromakalim; Dogs; Drug Interactions; Electric Stimulation; Female; Gallopamil; Glyburide; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Stereoisomerism | 1992 |
Characteristics of the contractile response of rabbit aorta produced by cromakalim in calcium-free solution.
Topics: Animals; Aorta; Benzopyrans; Calcium; Colforsin; Cromakalim; Guanidines; Male; Microelectrodes; Minoxidil; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitroglycerin; Pinacidil; Potassium; Potassium Channels; Pyridines; Pyrroles; Rabbits; Vasoconstriction | 1992 |
Effect of Rb+ on cromakalim-induced relaxation and ion fluxes in guinea pig trachea.
Topics: Albuterol; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Potassium; Pyrroles; Rubidium; Rubidium Radioisotopes; Trachea; Verapamil | 1992 |
The involvement of potassium channels in the action of ciclazindol in rat portal vein.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Indoles; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vasoconstriction; Vasodilator Agents | 1992 |
Comparison of the actions of acetylcholine and BRL 38227 in the guinea-pig coronary artery.
Topics: Acetylcholine; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Pyridines; Pyrroles; Rabbits; Scorpion Venoms; Vasodilator Agents | 1992 |
Effects of anti-asthma drugs and potassium channel openers on neurally-mediated contraction of isolated guinea pig trachea.
Topics: Acetylcholine; Aminophylline; Animals; Benzopyrans; Cromakalim; Electric Stimulation; Guinea Pigs; Hydrocortisone; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles; Trachea | 1992 |
Effects of the K+ channel blocker tedisamil on 86Rb efflux induced by cromakalim, high potassium and noradrenaline, and on mechanical tension in rabbit isolated vascular smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cardiotonic Agents; Cromakalim; Cyclopropanes; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Rubidium | 1992 |
The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways: comparison with pinacidil and verapamil.
Topics: Animals; Benzopyrans; Bronchi; Bronchial Spasm; Bronchodilator Agents; Carbachol; Cromakalim; Drug Interactions; Female; Guanidines; Guinea Pigs; Humans; Male; Muscle Contraction; Pinacidil; Potassium Channels; Pyrroles; Stereoisomerism; Trachea; Vasodilator Agents; Verapamil | 1992 |
Smooth muscle relaxation and inhibition of responses to pinacidil and cromakalim induced by phentolamine in guinea-pig isolated trachea.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dinoprost; Female; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phentolamine; Pinacidil; Pyrroles; SRS-A; Trachea | 1992 |
Characterization of sulfonylurea receptors and the action of potassium channel openers on cholinergic neurotransmission in guinea pig isolated small intestine.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Benzopyrans; Choline; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; Intestine, Small; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Picolines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrans; Pyrroles; Receptors, Drug; Sulfonylurea Receptors; Synaptic Transmission; Tritium | 1991 |
Effects of cromakalim on neurally-mediated responses of guinea-pig tracheal smooth muscle.
Topics: Animals; Autonomic Nervous System; Benzopyrans; Bronchodilator Agents; Cromakalim; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neuromuscular Junction; Neurons; Parasympathetic Nervous System; Pyrroles; Synaptic Transmission; Trachea; Vagus Nerve | 1991 |
Existence of two components in the tonic contraction of rat aorta mediated by alpha 1-adrenoceptor activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Benzopyrans; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Carbamates; Cromakalim; In Vitro Techniques; Isoquinolines; Lanthanum; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nifedipine; Phenylcarbamates; Phenylephrine; Phosphatidylinositols; Piperazines; Protease Inhibitors; Pyrroles; Rats | 1991 |
Pre- and postsynaptic alpha-2 adrenoceptors as target for drug discovery.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Dioxanes; Dogs; Hyperglycemia; Hypoglycemic Agents; Hypothalamus; Idazoxan; In Vitro Techniques; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Norepinephrine; Pyrroles; Rats; Receptors, Adrenergic, alpha; Synapses | 1991 |
Effects of K+ channel blockers and cromakalim (BRL 34915) on the mechanical activity of guinea pig detrusor smooth muscle.
Topics: Animals; Benzopyrans; Charybdotoxin; Cromakalim; Drug Interactions; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurotransmitter Agents; Peptides; Potassium Channels; Pyrroles; Scorpion Venoms; Vasodilator Agents | 1991 |
Cromakalim effects of acetylcholine-induced changes in cytosolic calcium and tension in swine trachealis.
Topics: Acetylcholine; Animals; Benzopyrans; Bronchodilator Agents; Calcium; Cromakalim; Cytosol; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Pyrroles; Swine; Trachea | 1992 |
Actions of cromakalim in isolated human saphenous vein.
Topics: Antihypertensive Agents; Benzopyrans; Cromakalim; Dinoprost; Glyburide; Humans; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Norepinephrine; Potassium Chloride; Pyrroles; Saphenous Vein; Serotonin; Vasoconstriction | 1992 |
Cromakalim inhibits contractions of the rat isolated mesenteric bed induced by noradrenaline but not caffeine in Ca(2+)-free medium: evidence for interference with receptor-mediated Ca2+ mobilization.
Topics: Animals; Benzopyrans; Caffeine; Calcium; Cromakalim; Culture Media; Endothelium, Vascular; In Vitro Techniques; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Perfusion; Pyrroles; Rats; Ryanodine; Vasodilator Agents | 1991 |
Effects of lemakalim on changes in Ca2+ concentration and mechanical activity induced by noradrenaline in the rabbit mesenteric artery.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Escin; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Isometric Contraction; Male; Membrane Potentials; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Myelin Sheath; Neuromuscular Depolarizing Agents; Norepinephrine; Pyrroles; Rabbits; Vasodilator Agents | 1991 |
Inhibition by glibenclamide of the effects of cromakalim on responses of rat vas deferens to naphazoline.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naphazoline; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vas Deferens | 1991 |
The effect of potassium channel opening drugs on pulmonary nerves.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Lung; Muscle Contraction; Parasympathetic Nervous System; Parasympatholytics; Pyrroles; Trachea | 1991 |
The relationship of KCl- and prostaglandin F2 alpha-mediated increases in tension of the porcine coronary artery with changes in intracellular Ca2+ measured with fura-2.
Topics: Animals; Arteries; Benzopyrans; Biomechanical Phenomena; Calcium; Coronary Vessels; Cromakalim; Dinoprost; Fura-2; Membrane Potentials; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nitroprusside; Potassium Chloride; Pyrroles; Swine; Vasodilator Agents | 1991 |
Antidiabetic sulfonylureas relax isolated rabbit coronary arteries.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dinoprost; Hypoglycemic Agents; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium; Pyrroles; Rabbits; Sulfonylurea Compounds; Vasodilator Agents | 1991 |
NIP-121 and cromakalim, potassium channel openers, preferentially suppress prostanoid-induced contraction of the guinea-pig isolated trachea.
Topics: Animals; Arachidonic Acid; Benzopyrans; Cromakalim; Dinoprost; Glyburide; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Piperidines; Potassium Channels; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Pyrroles; Sulfonamides; Trachea | 1991 |
The dualistic mode of action of the vasodilator drug, nicorandil, differentiated by glibenclamide in 86Rb flux studies in rabbit isolated vascular smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Glyburide; Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Rubidium Radioisotopes; Stimulation, Chemical; Vasodilator Agents | 1991 |
Differential antagonism by glibenclamide of the relaxant effects of cromakalim, pinacidil and nicorandil on canine large coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Guanidines; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Pinacidil; Potassium; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasodilator Agents | 1991 |
The effect of cromakalim on the normal and hyper-reflexic human detrusor muscle.
Topics: Acetylcholine; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Pyrroles; Urinary Bladder | 1991 |
The diverse effects of cromakalim on tension and 86Rb efflux in canine arterial smooth muscle.
Topics: Animals; Arteries; Benzopyrans; Cromakalim; Dogs; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Potassium Channels; Pyrroles; Rubidium Radioisotopes | 1991 |
Comparison of the effects of the K(+)-channel openers cromakalim and minoxidil sulphate on vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Female; Guinea Pigs; In Vitro Techniques; Male; Mesenteric Arteries; Minoxidil; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1991 |
Effects of glibenclamide on cytosolic calcium concentrations and on contraction of the rabbit aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium; Cromakalim; Cytosol; Fura-2; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Pyrroles; Rabbits | 1991 |
Evidence that acetylcholine-mediated hyperpolarization of the rat small mesenteric artery does not involve the K+ channel opened by cromakalim.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; In Vitro Techniques; Membrane Potentials; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Phentolamine; Potassium Channels; Pyrroles; Rats; Rats, Inbred WKY; Swine; Vasodilator Agents | 1991 |
[Comparison of pharmacological profile of selective kappa-opioid agonist K-II and U-50488].
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Benzeneacetamides; Female; Male; Mice; Motor Activity; Muscle Contraction; Pyrroles; Pyrrolidines; Rabbits; Vas Deferens | 1991 |
Some degree of overlap exists between the K(+)-channels opened by cromakalim and those opened by minoxidil sulphate in rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Male; Minoxidil; Muscle Contraction; Muscle, Smooth, Vascular; Potassium; Potassium Channels; Potassium Radioisotopes; Pyrroles; Rats; Rats, Inbred Strains; Rubidium; Rubidium Radioisotopes; Vasodilator Agents | 1991 |
Synthesis and pharmacological evaluation of perhydropyrrolo [3,4-c]pyridine derivatives.
Topics: Acetylcholine; Animals; Chemical Phenomena; Chemistry; Dimethylphenylpiperazinium Iodide; Guinea Pigs; Histamine H1 Antagonists; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Pyridines; Pyrroles; Serotonin Antagonists; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1990 |
Effects of cromakalim (BRL 34915) on mechanical responses of rat vas deferens to noradrenaline and naphazoline.
Topics: Animals; Benzopyrans; Cromakalim; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naphazoline; Norepinephrine; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vas Deferens; Verapamil | 1991 |
Experimental hyperreflexia: effect of intravesical administration of various agents.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Diltiazem; Electric Stimulation; Electromyography; Hexamethonium Compounds; Male; Muscle Contraction; Nifedipine; Pyrroles; Rabbits; Reflex; Urinary Bladder Diseases; Vasodilator Agents; Verapamil | 1991 |
Evidence that pinacidil may promote the opening of ATP-sensitive K+ channels yet inhibit the opening of Ca2(+)-activated K+ channels in K(+)-contracted canine mesenteric artery.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Dogs; Female; Glyburide; Guanidines; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rubidium Radioisotopes | 1990 |
Characterization of responses to cromakalim and pinacidil in smooth and cardiac muscle by use of selective antagonists.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Clonidine; Coronary Vessels; Cromakalim; Dogs; Electric Stimulation; Glyburide; Guanidines; Guinea Pigs; Heart; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myocardial Contraction; Phentolamine; Pinacidil; Potassium Channels; Pyrroles; Rats | 1990 |
Hypoglycemic sulfonylureas antagonize the effects of cromakalim and pinacidil on 86Rb fluxes and contractile activity in the rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Parasympatholytics; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Sulfonylurea Compounds; Tetraethylammonium Compounds; Tolbutamide; Vasodilator Agents | 1990 |
Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicorandil.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Cytoplasm; Dogs; Female; Fluorescence; Glyburide; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Chloride; Pyrroles; Quaternary Ammonium Compounds | 1990 |
Endothelium-dependent and BRL 34915-induced vasodilatation in rat isolated perfused mesenteric arteries: role of G-proteins, K+ and calcium channels.
Topics: Acetylcholine; Animals; Benzopyrans; Calcimycin; Calcium Channel Blockers; Calcium Channels; Cromakalim; Endothelium, Vascular; GTP-Binding Proteins; Histamine; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Pertussis Toxin; Potassium Channels; Pyrroles; Rats; Vasodilator Agents; Virulence Factors, Bordetella | 1990 |
Characterization of kappa-opioid receptors in the guinea-pig ileum.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes | 1990 |
Mechanisms of inhibitory effects of CD-349 and K(+)-channel activators on noradrenaline-induced contraction and changes in levels of cyclic GMP in rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium Channel Agonists; Calcium Channel Blockers; Cromakalim; Cyclic GMP; Dihydropyridines; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1990 |
An approach to differentiate between noradrenaline-elicited contractile processes in the rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium; Calcium Channel Blockers; Cromakalim; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Protein Kinase C; Pyrroles; Rats; Rats, Inbred Strains; Ryanodine | 1990 |
Non-junctional modulation of neurogenic twitches of the guinea-pig ileum by some peptides and other compounds in the triple bath.
Topics: Action Potentials; Animals; Benzopyrans; Bradykinin; Capsaicin; Cromakalim; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neural Conduction; Neurotensin; Peptides; Pyrroles; Vasoactive Intestinal Peptide | 1990 |
K+ channel openers suppress myotonic activity of human skeletal muscle in vitro.
Topics: Benzopyrans; Cell Membrane Permeability; Cromakalim; Dihydropyridines; Humans; In Vitro Techniques; Microelectrodes; Muscle Contraction; Muscles; Potassium Channels; Pyrroles; Vasodilator Agents | 1990 |
Effects of cromakalim (BRL 34915) and pinacidil on normal and hypertrophied rat detrusor in vitro.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guanidines; Hypertrophy; In Vitro Techniques; Muscle Contraction; Pinacidil; Potassium; Pyrroles; Rats; Rats, Inbred Strains; Urinary Bladder; Vasodilator Agents | 1990 |
Enhancement of K+ conductance improves in vitro the contraction force of skeletal muscle in hypokalemic periodic paralysis.
Topics: Benzopyrans; Cromakalim; Humans; Hypokalemia; In Vitro Techniques; Muscle Contraction; Muscles; Paralyses, Familial Periodic; Potassium Channels; Pyrroles | 1990 |
K(+)-channel openers for relaxation of isolated penile erectile tissue from rabbit.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Papaverine; Penile Erection; Penis; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1990 |
Differences in Ca2+ handling along the arterial tree: an update including studies in human mesenteric resistance vessels.
Topics: Animals; Antihypertensive Agents; Arteries; Benzopyrans; Calcium; Calcium Channel Blockers; Cromakalim; Humans; In Vitro Techniques; Membrane Potentials; Mesenteric Arteries; Muscle Contraction; Norepinephrine; Pyrroles; Rabbits; Rats; Rats, Inbred Strains; Rats, Inbred WKY; Vascular Resistance | 1988 |
Endothelin-1-induced contractions of vascular and tracheal smooth muscle: effects of nicardipine and BRL 34915.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Endothelins; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Nicardipine; Parasympatholytics; Peptides; Pyrroles; Rats; Trachea | 1989 |
Effects of cromakalim and glibenclamide on isolated strips of bovine tracheal smooth muscle. Smooth Muscle Research Group.
Topics: Animals; Benzopyrans; Cattle; Cromakalim; Glyburide; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Pyrroles; Rubidium Radioisotopes; Trachea | 1989 |
Effect of cromakalim on smooth muscle cells of guinea-pig taenia caeci.
Topics: Animals; Benzopyrans; Cecum; Cromakalim; Electrophysiology; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Pyrroles | 1989 |
Glibenclamide is a competitive antagonist of cromakalim, pinacidil and RP 49356 in guinea-pig pulmonary artery.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Potassium Chloride; Pulmonary Artery; Purinones; Pyrans; Pyrroles; Tetraethylammonium Compounds | 1989 |
Functional changes in potassium channels in aortas from rats with streptozotocin-induced diabetes.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Glucose; Cromakalim; Diabetes Mellitus, Experimental; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Niacinamide; Nicorandil; Norepinephrine; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1989 |
Effect of cromakalim on contractions in rabbit isolated renal artery in the presence and absence of extracellular Ca2+.
Topics: Animals; Benzopyrans; Caffeine; Calcium; Calcium Channel Blockers; Cromakalim; Guanidines; Guanylate Cyclase; Histamine; In Vitro Techniques; Lanthanum; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitroprusside; Norepinephrine; Pinacidil; Pyrroles; Rabbits; Renal Artery; Vasodilator Agents | 1989 |
The effects of cromakalim on the detrusor muscle of human and pig urinary bladder.
Topics: Animals; Benzopyrans; Cromakalim; Female; Humans; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Swine; Urinary Bladder | 1989 |
The effect of cromakalim on the smooth muscle of the guinea-pig urinary bladder.
Topics: Animals; Benzopyrans; Cromakalim; Electrophysiology; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Potassium; Potassium Radioisotopes; Pyrroles; Rubidium Radioisotopes; Urinary Bladder | 1989 |
The effect of relaxants working through different transduction mechanisms on the tonic contraction produced in rat aorta by 4 beta-phorbol dibutyrate.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Colforsin; Cromakalim; In Vitro Techniques; Isoproterenol; Male; Methoxamine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Parasympatholytics; Phorbol 12,13-Dibutyrate; Pyrroles; Rats; Rats, Inbred Strains; Xanthines | 1989 |
PD117302: a selective agonist for the kappa-opioid receptor.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Corpus Striatum; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Pyrroles; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes; Vas Deferens | 1988 |
Anti-spasmogenic and spasmolytic effects of BRL 34915: a comparison with nifedipine and nicorandil.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Norepinephrine; Parasympatholytics; Potassium Chloride; Pyrroles; Rabbits | 1987 |
Effect of the K+ efflux stimulating vasodilator BRL 34915 on 86Rb+ efflux and spontaneous activity in guinea-pig portal vein.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antihypertensive Agents; Benzopyrans; Bucladesine; Cromakalim; Drug Interactions; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Potassium; Pyrroles; Radioisotopes; Rubidium; Vasodilator Agents | 1987 |
Dissociation of actions of BRL 34915 in the rat portal vein.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Potassium; Potassium Radioisotopes; Pyrroles; Rats; Rats, Inbred Strains | 1987 |
Comparison of the effects of BRL 34915 and verapamil on electrical and mechanical activity in rat portal vein.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Pyrroles; Rats; Rats, Inbred Strains; Verapamil | 1986 |
A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp.
Topics: Animals; Aorta; Biological Assay; Chemical Phenomena; Chemistry; Male; Muscle Contraction; Porifera; Pyrroles; Rabbits; Receptors, Serotonin; Spectrum Analysis | 1986 |
The role of PMN-leukocyte lysosomes in tissue injury, inflammation and hypersensitivity. 8. Mode of action and properties of vascular permeability factors released by PMN-leukocytes during 'in vitro' phagocytosis.
Topics: Animals; Ascitic Fluid; Autacoids; Capillary Permeability; Chromatography; Chromatography, Gel; Cytoplasmic Granules; Electrophoresis; Female; Gels; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Ileum; Inflammation; Leukocytes; Lung; Lysosomes; Mast Cells; Membranes, Artificial; Muscle Contraction; Muscle, Smooth; Phagocytosis; Prostaglandins; Proteins; Pyrroles; Rabbits; Rats; Serotonin; Ultracentrifugation; Uterus; Wounds and Injuries | 1971 |
The binding of conformationally restricted antihistamines to histamine receptors.
Topics: Aminobutyrates; Animals; Guinea Pigs; Histamine; Histamine H1 Antagonists; Ileum; Molecular Conformation; Muscle Contraction; Muscle, Smooth; Proline; Pyrroles; Receptors, Drug; Spectrum Analysis; Stereoisomerism; Structure-Activity Relationship | 1973 |
The pharmacology of batrachotoxin. I. Effects on the contractile mechanism and on neuromuscular transmission of mammalian skeletal muscle.
Topics: Acetates; Alkaloids; Animals; Antitoxins; Anura; Caffeine; Calcium Chloride; Cell Membrane Permeability; Diaphragm; Drug Antagonism; Drug Synergism; Electric Stimulation; In Vitro Techniques; Membrane Potentials; Microscopy, Electron; Muscle Contraction; Muscles; Neuromuscular Depolarizing Agents; Nitriles; Phrenic Nerve; Potassium Chloride; Pyrroles; Rats; Sarcoplasmic Reticulum; Sodium; Steroids; Synaptic Transmission; Temperature; Tetrodotoxin; Time Factors; Toxins, Biological; Tubocurarine | 1971 |
The pharmacology of batrachotoxin. V. A comparative study of membrane properties and the effect of batrachotoxin on sartorius muscles of the frogs Phyllobates aurotaenia and Rana pipiens.
Topics: Action Potentials; Alkaloids; Animals; Anura; Caffeine; Cell Membrane; Cell Membrane Permeability; Cholinesterases; Histocytochemistry; Hydroxysteroids; In Vitro Techniques; Membrane Potentials; Microscopy, Electron; Muscle Contraction; Muscles; Neuromuscular Junction; Potassium; Pyrroles; Rana pipiens; Sciatic Nerve; Sodium; Species Specificity; Tetrodotoxin; Time Factors; Toxins, Biological | 1973 |
The pharmacology of batrachotoxin. IV. Interaction with tetrodotoxin on innervated and chronically denervated rat skeletal muscle.
Topics: Acetylcholine; Action Potentials; Alkaloids; Animals; Anura; Denervation; Drug Interactions; Electric Stimulation; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscles; Neuromuscular Depolarizing Agents; Osmolar Concentration; Pregnanes; Pyrroles; Rats; Rats, Inbred Strains; Sodium; Tetrodotoxin; Toxins, Biological | 1972 |
Isolation of a pharmacologically active principle from Ehrlich carcinoma tumor cells.
Topics: Animals; Atropine; Blood Pressure; Carcinoma, Ehrlich Tumor; Female; Ileum; In Vitro Techniques; Lysergic Acid Diethylamide; Methods; Mice; Muscle Contraction; Peritoneum; Pyrroles; Tissue Extracts; Uterus | 1971 |
Effects of chlorpheniramine and pyrilamine on the atrial actions of acetylcholine, tyramine, and ephedrine.
Topics: Acetylcholine; Animals; Atropine; Chlorpheniramine; Cocaine; Ephedrine; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Physostigmine; Procaine; Pyrroles; Rabbits; Receptors, Drug; Time Factors; Tyramine | 1969 |
Pyrrolo[3,2,1-jk][1,4]benzodiazepines and pyrrolo[1,2,3-ef][1,5]benzodiazepines which have central nervous system activity.
Topics: Animals; Behavior, Animal; Benzazepines; Central Nervous System; Chemical Phenomena; Chemistry; Diazepam; Male; Mice; Muscle Contraction; Nicotine; Pyrroles; Reflex; Seizures | 1970 |