pyrroles has been researched along with Melanoma in 88 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.27) | 18.7374 |
| 1990's | 2 (2.27) | 18.2507 |
| 2000's | 27 (30.68) | 29.6817 |
| 2010's | 48 (54.55) | 24.3611 |
| 2020's | 9 (10.23) | 2.80 |
| Authors | Studies |
|---|---|
| Blackham, A; Box, J; Demberger, L; Federowicz, B; Friedland, JC; Ginn, S; Horton, M; Knoerzer, D; McIntosh, A; Nair, S; Shapiro, M; Sheikh, H; Stuhlmiller, TJ; Wolfe, Z | 1 |
| Catania, C; Cocorocchio, E; Conforti, F; Corti, C; Curigliano, G; de Pas, T; Ferrucci, PF; Pala, L; Queirolo, P | 1 |
| Mirian, M; Rostami, M; Varshosaz, J; Veisi, H | 1 |
| Abduvakhidov, A; Campiglia, P; d'Aulisio Garigliota, ML; Fattorusso, C; Ferraro, MG; Galatello, P; Iannece, P; Irace, C; Persico, M; Piccolo, M; Ramunno, A; Tkachuk, O; Varra, M | 1 |
| Aplin, AE; Chervoneva, I; Erkes, DA; Field, CO; Rosenbaum, SR; Villanueva, J | 1 |
| Badorrey, R; Castán, A; Christoffersen, CT; Díaz-de-Villegas, MD; Díez, JA; Gálvez, JA; Kehler, J; Köhler, R; Rasmussen, LK | 1 |
| Alikhan, M; Jogi, R; Nguyen, JK; Patel, AB; Schlichte, MJ | 1 |
| Bonkobara, M; Kurita, S; Michishita, M; Miyamoto, R; Nagashima, T; Noguchi, S; Tamura, K; Tani, H; Yayoshi, N | 1 |
| Andersen, LMK; Gaustad, JV; Rofstad, EK; Simonsen, TG | 1 |
| Chervoneva, I; Mastrangelo, MJ; Orloff, M; Sato, R; Sato, T; Shields, CL; Shields, JA; Valsecchi, ME | 1 |
| Luo, Q; Qian, Y; Qiao, S; Xu, G; Zhang, Z | 1 |
| Click, B; Regueiro, M | 1 |
| Aplin, AE; Chervoneva, I; Erkes, DA; Nikbakht, N; Tiago, M | 1 |
| Aplin, AE; Berger, AC; Capparelli, C; Chervoneva, I; Erkes, DA; Field, CO; Hartsough, EJ; Purwin, TJ; Tiago, M; Villanueva, J | 1 |
| Cuozzo, P; Fattorusso, C; Fiore, D; Forte, G; Franceschelli, S; Gazzerro, P; Pascale, M; Proto, MC; Ramunno, A | 1 |
| Bennett, KL; Borgdorff, V; Breitwieser, FP; Colinge, J; Gridling, M; Müller, AC; Rix, U; Superti-Furga, G; Wagner, C; Wagner, SN; Winter, GE | 1 |
| Busch, C; de Wijn, R; Geisler, J; Kristensen, V; Lønning, PE; Ree, AH; Risberg, K; Røe, K; Tahiri, A | 1 |
| Sato, T; Valsecchi, ME | 1 |
| Bastian, BC; Chen, X; Emery, C; Jager, MJ; Porter, D; Tan, L; Wu, Q | 1 |
| Dell'Aquila, E; Frezza, AM; Grasso, RF; Guida, FM; Lanzetta, G; Santini, D; Silletta, M; Silvestris, N; Tonini, G; Venditti, O; Vincenzi, B | 1 |
| Croft, A; Farrelly, ML; Hersey, P; Jiang, CC; Wroblewski, D; Zhang, XD | 1 |
| Ambrosini, G; de Stanchina, E; Musi, E; Schwartz, GK | 1 |
| Cooper, ZA; Ferrone, CR; Ferrone, S; Flaherty, KT; Frederick, DT; Kirkwood, JM; Pepe, S; Pepin, D; Sabbatino, F; Scognamiglio, G; Wang, X; Wang, Y; Wargo, JA; Yu, L | 1 |
| Higashihara, M; Horie, R; Umezawa, K; Watanabe, M | 1 |
| Chen, YC; Chin, SY; Chou, CL; Jiang, MC; Lee, WR; Liu, KH; Shen, SC; Shih, YH; Tseng, JT | 1 |
| Adamus, G; Amundson, D; Boon, CJ; Haanen, JB; Jager, MJ; Kapiteijn, EH; Keunen, JE; Luyten, GP; Marinkovic, M; van Dijk, EH; van Herpen, CM | 1 |
| Buchbinder, EI; Giobbie-Hurder, A; Hodi, FS; Lawrence, DP; Linette, GP; McDermott, DF; Ramaiya, NH; Sosman, JA; Van den Abbeele, AD | 1 |
| Aiello, F; Andreasi, RB; Belmonte, G; Cervellati, F; Maellaro, E; Maioli, E; Muresan, XM; Sticozzi, C; Valacchi, G | 1 |
| Anckaert, E; Baurain, JF; De Brakeleer, S; De Grève, J; De Mey, J; Decoster, L; Majois, F; Neyns, B; Rorive, A; Rottey, S; Vande Broek, I | 1 |
| Chen, CY; Chou, YW; Hu, WP; Kuo, KK; Lee, JH; Lin, YT; Senadi, GC; Wang, JJ; Wang, YC | 1 |
| Almeida, A; Fujita, M; Lambert, K; Lu, Y; Luo, Y; Mukherjee, N; Norris, DA; Robinson, SE; Robinson, WA; Shellman, YG; Shiau, CW; Su, JC | 1 |
| Carita, G; Cassoux, N; Dahmani, A; De Koning, L; Decaudin, D; Emery, C; Frisch-Dit-Leitz, E; Halilovic, E; Jeay, S; Laurent, C; Némati, F; Piperno-Neumann, S; Raymondie, C; Roman-Roman, S; Schoumacher, M; Wylie, A | 1 |
| Ghanem, G; Krayem, M; Ondrušová, L; Réda, J; Vachtenheim, J; Vlčková, K | 1 |
| Huang, L; Huo, M; Satterlee, AB; Wang, Y; Xu, Y; Zhao, Y | 1 |
| Babagana, M; Bshara, W; Johnson, S; Kandel, ES; Morrison, C; Slabodkin, H | 1 |
| Alexandrescu, DT; Dasanu, CA; Farzanmehr, H; McClure, R | 1 |
| Ashida, A; Kido, K; Murata, H; Saida, T; Takata, M | 1 |
| Montgomery, JP; Patterson, PH | 1 |
| Hohenegger, M; Minichsdorfer, C | 1 |
| Azzoli, CG; Calcutt, MW; Janjigian, YY; Kris, MG; Krug, LM; Lee, W; Miller, VA; Rizvi, NA; Senturk, E | 1 |
| Hersey, P; Jiang, CC; Wroblewski, D; Yang, F; Zhang, XD | 1 |
| Baritaki, S; Berenson, J; Bonavida, B; Palladino, M; Yeung, K | 1 |
| Baek, D; Cho, JH; Choi, WK; El-Gamal, MI; Hah, JM; Jung, MH; Kim, H; Lee, SH; Oh, CH; Park, JH; Sim, TB; Yoo, KH | 1 |
| Huelsmeyer, MK; Kurzman, ID; Mitzey, AM; Qurollo, B; Rose, BJ; Thamm, DH | 1 |
| Ardinghi, C; Bani, MR; Bernasconi, S; Carraro, F; Ghilardi, C; Giavazzi, R; Naldini, A; Oliva, P; Silini, A | 1 |
| Austin, B; Ghodousi, A; Hansen, D; Jamil, A; Skibo, EB | 1 |
| Gangjee, A; Ihnat, MA; Kurup, S; Shenoy, SS; Thorpe, JE | 1 |
| Abrantes, AM; Beja, AM; Botelho, MF; Brito, AF; Laranjo, M; Paixão, JA; Pinho E Melo, TM; Silva, MR; Soares, MI | 1 |
| Borden, EC; Byzova, TV; Kerr, BA; Malinin, NL; Merkulova, AA; Podrez, EA; Salomon, RG; Tischenko, M; West, XZ | 1 |
| Baryshnikov, A; Grigorieva, I; Lichinitser, M; Solomko, E; Stepanova, E; Vartanian, A | 1 |
| Abal, L; Casanova, JM; Dolcet, X; Egido, R; Llombart-Cussac, A; Martí, RM; Matias-Guiu, X; Moreno, S; Puig, S; Santacana, M; Sorolla, A; Valls, J; Velasco, A; Vilella, R; Yeramian, A | 1 |
| El-Gamal, MI; Jung, MH; Lee, WS; Oh, CH; Sim, T; Yoo, KH | 1 |
| Choi, JM; Kang, SJ; Kim, J; Kim, YS; Lee, JS; Lee, MH; Oh, TK; Park, S; Ryu, S; Yoon, JH | 1 |
| Chang, LS; Hsieh, MC; Hu, WP; Kao, YH; Wang, JJ; Wu, WC; Yu, HS | 1 |
| Bender, C; Ullrich, A | 1 |
| Drabkin, HA; Gemmill, RM; Lay, A; Lee, L; Lloyd, GK; Longenecker, A; McConkey, DJ; Millward, M; Neuteboom, ST; Palladino, MA; Price, T; Sharma, G; Spear, MA; Spencer, A; Sukumaran, S; Sweeney, C; Townsend, A | 1 |
| Espona-Fiedler, M; Gao, T; Guallar, V; Hosseini, A; Lizcano, JM; Pérez-Tomás, R; Quesada, R; Soto-Cerrato, V | 1 |
| Bastian, BC; Garrido, M; Hamid, O; Kashani-Sabet, M; Minor, DR; O'Day, SJ | 1 |
| Abdel-Maksoud, MS; El-Gamal, MI; Jung, MH; Oh, CH; Sim, T; Yoo, KH | 1 |
| Fletcher, JA; Hodi, FS; Li, J; Wu, X; Zhu, M | 1 |
| Gaustad, JV; Leinaas, MN; Rofstad, EK; Simonsen, TG | 1 |
| Chan, K; Laudadio, M; Mahipal, A; Mastrangelo, MJ; Sato, T; Tijani, L | 1 |
| Cucinotta, M; Oteri, R; Teti, D; Venza, I; Venza, M; Visalli, M | 1 |
| Chang, LS; Chen, CY; Chen, YK; Hsu, CC; Hu, WP; Lin, HC; Sung, PJ; Tsai, FY; Wang, JJ | 1 |
| Arstrand, K; Johansson, M; Kågedal, B; Lenner, L; Takasaki, A | 1 |
| Ademefun, T; Cooper, N; Hagan, DR; Howard, PW; Matthews, CS; Thurston, DE; Tiberghien, A | 1 |
| Hoekman, K; Kakkar, AK; Kostense, PJ; Kuenen, BC; Levi, M; Meijers, JC; Pinedo, HM; van Hinsbergh, VW | 1 |
| Carranza, DC; Chen, IY; Collisson, EA; Kolodney, MS | 1 |
| Chen, YC; Hu, WP; Wang, JJ; Yu, HS | 1 |
| Baselga, J; Cavalli, F; Conte, PF; Deplanque, G; Harris, AL; Hoekman, K; Huisman, H; Kuenen, BC; Madhusudan, S; Pfanner, E; Scigalla, P; Seeber, S; Tabernero, J | 1 |
| Collisson, EA; De, A; Gambhir, SS; Kleer, C; Kolodney, MS; Merajver, SD; Wu, M | 1 |
| Gajewski, TF; Karczmar, G; Medved, M; Peterson, AC; Stadler, WM; Swiger, S | 1 |
| Dignam, J; Gajewski, TF; Karczmar, G; Kindler, H; MacEneany, P; Medved, M; Mitchell, MT; Stadler, WM; Vokes, E; Yang, C | 1 |
| Bae, JH; Chung, BS; Ju, DS; Kang, CD; Kim, DW; Kim, MJ; Kim, SH; Kwon, JK; Um, JH | 1 |
| Hsieh, MC; Hsu, MH; Hsu, MK; Hu, WP; Lin, FL; Shen, YK; Wang, JJ | 1 |
| Innocenti, R; Loria, DI; Mossotti, R; Rosso, S; Zanetti, R; Zoccola, M | 1 |
| Beeram, M; Berg, K; de Bono, JS; Eckhart, SG; Forero, L; Hammond, LA; Izbicka, E; Mita, AC; Mita, MM; Patnaik, A; Rowinsky, EK; Simmons, P; Takimoto, C; Tolcher, AW; Weiss, GR | 1 |
| Dellavalle, RP; Drake, AL; Freeman, SR; Graber, M; Heilig, LF; McNealy, K; Schilling, LM | 1 |
| Balzi, D; Barbera, C; Chirlaque, MD; Fabbrocini, G; Greinert, R; Lauria, C; Loria, D; Mercier, M; Miranda, A; Nieto, A; Rosso, S; Sánchez, MJ; Sancho-Garnier, H; Zanetti, R; Zoccola, M; Østerlind, A | 1 |
| Kim, YS; Lee, J; Park, D | 1 |
| Acoca, S; Beauparlant, P; Bélec, L; Billot, X; Cluse, L; Goulet, D; Johnstone, RW; Marcellus, RC; Murthy Madiraju, SR; Nguyen, M; Purisima, E; Roulston, A; Serfass, L; Shore, GC; Viallet, J; Watson, M; Wiegmans, A | 1 |
| Baig, MA; Coffils, M; Hartley, JA; Howard, PW; Jenkins, TC; Loadman, PM; Suggitt, M; Thurston, DE; Wells, G | 1 |
| Carstam, R; Hindemith, A; Odh, G; Paulson, J; Rorsman, H; Rosengren, E | 1 |
| Heileman, MJ; Islam, I; Schulz, WG; Skibo, EB | 1 |
| Swan, GA | 1 |
| Cohn, Z; Gordon, S | 1 |
5 review(s) available for pyrroles and Melanoma
| Article | Year |
|---|---|
A case of new-onset vitiligo in a patient on tofacitinib and brief review of paradoxical presentations with other novel targeted therapies.
Topics: Adult; Arthritis, Rheumatoid; Female; Hidradenitis Suppurativa; Humans; Janus Kinase Inhibitors; Keratoacanthoma; Melanoma; Piperidines; Programmed Cell Death 1 Receptor; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Psoriasis; Pyrimidines; Pyrroles; Tumor Necrosis Factor-alpha; Vitiligo | 2020 |
Managing Risks with Biologics.
Topics: Antibodies, Monoclonal, Humanized; Biological Products; Demyelinating Diseases; Deprescriptions; Drug Substitution; Gastrointestinal Agents; Humans; Infections; Inflammatory Bowel Diseases; Lymphoma; Melanoma; Neoplasms; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Risk; Risk Assessment; Skin Neoplasms; Tumor Necrosis Factor-alpha; Ustekinumab | 2019 |
The potential role of sunitinib targeting melanomas.
Topics: Animals; Antineoplastic Agents; Humans; Indoles; Melanoma; Pyrroles; Skin Neoplasms; Sunitinib; Uveal Neoplasms | 2013 |
Statins, fibrates, and melanoma risk: a systematic review and meta-analysis.
Topics: Atorvastatin; Bezafibrate; Clofibrate; Gemfibrozil; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Incidence; Lovastatin; Melanoma; Odds Ratio; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Reproducibility of Results; Simvastatin; Skin Neoplasms; United States | 2006 |
Structure, chemistry, and biosynthesis of the melanins.
Topics: Animals; Birds; Carbon Radioisotopes; Catechol Oxidase; Catechols; Chemical Phenomena; Chemistry; Dihydroxyphenylalanine; Dopamine; Electron Spin Resonance Spectroscopy; Eye; Feathers; Hair; Humans; Indoles; Liver; Magnetic Resonance Spectroscopy; Melanins; Melanoma; Mice; Oxidation-Reduction; Pyrroles; Rats; Spectrophotometry, Ultraviolet; Tyrosine; X-Ray Diffraction | 1974 |
11 trial(s) available for pyrroles and Melanoma
| Article | Year |
|---|---|
Serous Retinopathy Associated with Mitogen-Activated Protein Kinase Kinase Inhibition (Binimetinib) for Metastatic Cutaneous and Uveal Melanoma.
Topics: Adult; Aged; Autoantibodies; Benzimidazoles; Central Serous Chorioretinopathy; Cross-Sectional Studies; Drug Combinations; Electrooculography; Electroretinography; Eye Proteins; Female; Fluorescein Angiography; Humans; Male; Melanoma; Melanoma, Cutaneous Malignant; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Prospective Studies; Protein Kinase C; Pyrroles; Quinazolines; Skin Neoplasms; Subretinal Fluid; Tomography, Optical Coherence; Uveal Neoplasms; Visual Acuity | 2015 |
Phase 2 study of sunitinib in patients with metastatic mucosal or acral melanoma.
Topics: Antineoplastic Agents; Female; Humans; Indoles; Male; Melanoma; Mucous Membrane; Mutation; Proto-Oncogene Proteins c-kit; Pyrroles; Skin Neoplasms; Sunitinib | 2015 |
Biomarker Analysis in a Phase II Study of Sunitinib in Patients with Advanced Melanoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Tumor; Endothelial Cells; Endpoint Determination; Female; Humans; Indoles; Male; Melanoma; Middle Aged; Mutation; Neovascularization, Pathologic; Placenta Growth Factor; Pregnancy Proteins; Proto-Oncogene Proteins c-kit; Pyrroles; Skin Neoplasms; Sunitinib; Survival Analysis; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2015 |
A phase I trial of SJG-136 (NSC#694501) in advanced solid tumors.
Topics: Aged; Antineoplastic Agents; Benzodiazepinones; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Female; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Ovarian Neoplasms; Pyrroles; Urinary Bladder Neoplasms | 2010 |
Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Drug Combinations; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lactones; Lung Neoplasms; Male; Melanoma; Middle Aged; Pancreatic Neoplasms; Proteasome Inhibitors; Pyrroles; Vorinostat | 2012 |
A pilot study of sunitinib malate in patients with metastatic uveal melanoma.
Topics: Adult; Aged; Female; Humans; Indoles; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Pilot Projects; Prognosis; Proto-Oncogene Proteins c-kit; Pyrroles; Sunitinib; Treatment Outcome; Uveal Neoplasms | 2012 |
Analysis of coagulation cascade and endothelial cell activation during inhibition of vascular endothelial growth factor/vascular endothelial growth factor receptor pathway in cancer patients.
Topics: Angiogenesis Inhibitors; Blood Coagulation; Blood Platelets; Carcinoma, Renal Cell; Cell Division; Cell Membrane Permeability; Cell Movement; Drug Administration Schedule; Endothelium, Vascular; Fibrinolysis; Hemostasis; Humans; Indoles; Kidney Neoplasms; Melanoma; Neovascularization, Pathologic; Protein C; Proto-Oncogene Proteins; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Sarcoma; Thrombin; Vascular Endothelial Growth Factor Receptor-1 | 2002 |
Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma.
Topics: Adult; Aged; Angiogenesis Inhibitors; Carcinoma, Renal Cell; Disease-Free Survival; Enzyme Inhibitors; Female; Humans; Indoles; Kidney Neoplasms; Male; Melanoma; Middle Aged; Neovascularization, Pathologic; Protein-Tyrosine Kinases; Pyrroles; Sarcoma; Skin Neoplasms; Treatment Outcome | 2003 |
Phase II study of the Flk-1 tyrosine kinase inhibitor SU5416 in advanced melanoma.
Topics: Adult; Aged; Angiogenesis Inhibitors; Female; Glucose; Humans; Indoles; Lymphocytes; Magnetic Resonance Imaging; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Neovascularization, Pathologic; Protein Kinase Inhibitors; Pyrroles; Time Factors; Treatment Outcome; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2004 |
Semiquantitative analysis of dynamic contrast enhanced MRI in cancer patients: Variability and changes in tumor tissue over time.
Topics: Angiogenesis Inhibitors; Colonic Neoplasms; Contrast Media; Gadolinium DTPA; Humans; Indoles; Liver; Liver Neoplasms; Magnetic Resonance Imaging; Melanoma; Mesothelioma; Muscle, Skeletal; Protein-Tyrosine Kinases; Pyrroles | 2004 |
A phase II, pharmacokinetic, and biologic study of semaxanib and thalidomide in patients with metastatic melanoma.
Topics: Adult; Aged; Angiogenesis Inhibitors; Area Under Curve; Asthenia; Dose-Response Relationship, Drug; Edema; Female; Half-Life; Headache; Humans; Indoles; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Peripheral Nervous System Diseases; Protein Kinase Inhibitors; Pyrroles; Thalidomide; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Venous Thrombosis | 2007 |
72 other study(ies) available for pyrroles and Melanoma
| Article | Year |
|---|---|
Case report: response to the ERK1/2 inhibitor ulixertinib in BRAF D594G cutaneous melanoma.
Topics: Aminopyridines; Cell Line, Tumor; Humans; MAP Kinase Signaling System; Melanoma; Melanoma, Cutaneous Malignant; Mitogen-Activated Protein Kinase Kinases; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Pyrroles; Skin Neoplasms | 2022 |
Differential activity of avapritinib in patients with metastases from mucosal melanoma and thymic carcinoma harbouring KIT exon 17 mutations: Initial experience from a Compassionate Use Program in Italy.
Topics: Antineoplastic Agents; Compassionate Use Trials; Exons; Gastrointestinal Stromal Tumors; Humans; Melanoma; Mutation; Precision Medicine; Proto-Oncogene Proteins c-kit; Pyrazoles; Pyrroles; Thymoma; Thymus Neoplasms; Triazines | 2022 |
Thermosensitive TMPO-oxidized lignocellulose/cationic agarose hydrogel loaded with deferasirox nanoparticles for photothermal therapy in melanoma.
Topics: Deferasirox; Humans; Hydrogels; Iron; Melanoma; Nanoparticles; Nuclear Proteins; Photothermal Therapy; Polymers; Pyrroles; Sepharose; Thymopoietins | 2023 |
Tetrasubstituted Pyrrole Derivative Mimetics of Protein-Protein Interaction Hot-Spot Residues: A Promising Class of Anticancer Agents Targeting Melanoma Cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Melanoma; Molecular Structure; Pyrroles; Structure-Activity Relationship | 2023 |
PLX3397 inhibits the accumulation of intra-tumoral macrophages and improves bromodomain and extra-terminal inhibitor efficacy in melanoma.
Topics: Aminopyridines; Animals; Cell Line, Tumor; Cell Proliferation; Macrophages; Male; Melanoma; Mice, Inbred C57BL; Proteins; Proto-Oncogene Proteins B-raf; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Skin Neoplasms; Treatment Outcome | 2020 |
Debenzylative Cycloetherification as a Synthetic Tool in the Diastereoselective Synthesis of 3,6-Disubstituted Hexahydro-2
Topics: Cell Proliferation; Humans; Melanoma; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrroles; Structure-Activity Relationship | 2020 |
A canine case of malignant melanoma carrying a KIT c.1725_1733del mutation treated with toceranib: a case report and in vitro analysis.
Topics: Animals; Antineoplastic Agents; Base Sequence; Dog Diseases; Dogs; Gene Deletion; Genetic Predisposition to Disease; Gingival Neoplasms; Indoles; Lymphatic Metastasis; Male; Melanoma; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrroles | 2021 |
Antiangiogenic agents targeting different angiogenic pathways have opposite effects on tumor hypoxia in R-18 human melanoma xenografts.
Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Female; Humans; Indoles; Melanoma; Mice; Neovascularization, Pathologic; Peptide Fragments; Properdin; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Sunitinib; Tumor Hypoxia; Xenograft Model Antitumor Assays | 2017 |
Adjuvant Sunitinib in High-Risk Patients with Uveal Melanoma: Comparison with Institutional Controls.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chemotherapy, Adjuvant; Female; Follow-Up Studies; Humans; Incidence; Indoles; Male; Melanoma; Middle Aged; Proportional Hazards Models; Pyrroles; Retrospective Studies; Risk Assessment; Sunitinib; Survival Rate; Treatment Outcome; United States; Uveal Neoplasms; Young Adult | 2018 |
Long-term characterization of activated microglia/macrophages facilitating the development of experimental brain metastasis through intravital microscopic imaging.
Topics: Aminopyridines; Animals; Brain; Brain Neoplasms; Cell Line, Tumor; CX3C Chemokine Receptor 1; Disease Models, Animal; Functional Laterality; Gene Expression Regulation, Neoplastic; Green Fluorescent Proteins; Intravital Microscopy; Macrophages; Matrix Metalloproteinase 3; Melanoma; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Pyrroles; Time Factors; Zonula Occludens-1 Protein | 2019 |
BET Inhibition Modifies Melanoma Infiltrating T Cells and Enhances Response to PD-L1 Blockade.
Topics: Animals; Antineoplastic Agents, Immunological; CD8-Positive T-Lymphocytes; Cell Growth Processes; Cell Line, Tumor; Disease Models, Animal; Drug Synergism; Forkhead Transcription Factors; Humans; Immunotherapy; Lymphocytes, Tumor-Infiltrating; Melanoma; Mice; Nerve Tissue Proteins; Oxazoles; Programmed Cell Death 1 Receptor; Pyridines; Pyrroles; Receptors, Cell Surface; Skin Neoplasms; T-Lymphocytes, Regulatory; Tumor Burden | 2019 |
The next-generation BET inhibitor, PLX51107, delays melanoma growth in a CD8-mediated manner.
Topics: Animals; Antineoplastic Agents; Apoptosis; CD8-Positive T-Lymphocytes; Cell Proliferation; Humans; Male; Melanoma; Mice; Mice, Inbred C57BL; Oxazoles; Proteins; Pyridines; Pyrroles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2019 |
Tetra-substituted pyrrole derivatives act as potent activators of p53 in melanoma cells.
Topics: Apoptosis; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; HSP90 Heat-Shock Proteins; Humans; Imidazoles; Melanoma; Melanoma, Cutaneous Malignant; Mutation; Piperazines; Proto-Oncogene Proteins c-mdm2; Pyrroles; Skin Neoplasms; Transcription, Genetic; Tumor Suppressor Protein p14ARF; Tumor Suppressor Protein p53 | 2020 |
A chemical biology approach identifies AMPK as a modulator of melanoma oncogene MITF.
Topics: AMP-Activated Protein Kinases; Blotting, Western; Cell Line; Cell Survival; Chromatography, Liquid; Enzyme Inhibitors; Fluorescent Antibody Technique; Humans; Indoles; Mass Spectrometry; Melanocytes; Melanoma; Microphthalmia-Associated Transcription Factor; Oncogenes; Pyrroles; RNA Interference; RNA, Small Interfering; Staurosporine; Sunitinib; Transfection | 2014 |
Differential inhibition of ex-vivo tumor kinase activity by vemurafenib in BRAF(V600E) and BRAF wild-type metastatic malignant melanoma.
Topics: Aged; Cell Line, Tumor; Cluster Analysis; ErbB Receptors; Female; Humans; Indoles; Male; Melanoma; Middle Aged; Mutant Proteins; Mutation; Neoplasm Metastasis; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Skin; Skin Neoplasms; Substrate Specificity; Sulfonamides; Sunitinib; Vemurafenib | 2013 |
Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Female; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Inhibitory Concentration 50; MAP Kinase Kinase Kinases; Melanoma; Mice; Mice, Inbred C57BL; Mice, Nude; Mutation, Missense; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Signal Transduction; Tumor Burden; Uveal Neoplasms; Xenograft Model Antitumor Assays | 2014 |
Sunitinib in malignant melanoma: a treatment option only for KIT-mutated patients?
Topics: Aged; Biomarkers, Pharmacological; Carcinoma, Renal Cell; Humans; Indoles; Liver Neoplasms; Lung Neoplasms; Male; Melanoma; Mutation; Proto-Oncogene Proteins c-kit; Pyrroles; Skin Neoplasms; Sunitinib | 2013 |
OBATOCLAX and ABT-737 induce ER stress responses in human melanoma cells that limit induction of apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Biphenyl Compounds; Calcium; Cell Line, Tumor; Cytosol; Drug Resistance, Neoplasm; Endoplasmic Reticulum Stress; Humans; Indoles; Melanoma; Myeloid Cell Leukemia Sequence 1 Protein; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Unfolded Protein Response; Up-Regulation | 2013 |
The phosphoinositide 3-kinase α selective inhibitor BYL719 enhances the effect of the protein kinase C inhibitor AEB071 in GNAQ/GNA11-mutant uveal melanoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Silencing; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Melanoma; Mice; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrroles; Quinazolines; RNA Interference; Signal Transduction; Thiazoles; Tumor Burden; Uveal Neoplasms; Xenograft Model Antitumor Assays | 2014 |
PDGFRα up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation.
Topics: Animals; Antineoplastic Agents; Benzamides; Benzimidazoles; Biphenyl Compounds; Cell Line, Tumor; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Gene Silencing; Hedgehog Proteins; Humans; Imatinib Mesylate; Indoles; MAP Kinase Signaling System; Melanoma; Mice; Piperazines; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor alpha; RNA, Small Interfering; Sulfonamides; Sunitinib; Up-Regulation; Vemurafenib | 2014 |
Combined inhibition of NF-κB and Bcl-2 triggers synergistic reduction of viability and induces apoptosis in melanoma cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Cell Line, Tumor; Cell Survival; Cyclohexanones; Drug Synergism; Humans; Indoles; Melanoma; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Signal Transduction; Tumor Cells, Cultured | 2013 |
Early decline in serum phospho-CSE1L levels in vemurafenib/sunitinib-treated melanoma and sorafenib/lapatinib-treated colorectal tumor xenografts.
Topics: Animals; Antibodies, Neoplasm; Cell Line, Tumor; Cell Proliferation; Cellular Apoptosis Susceptibility Protein; Colorectal Neoplasms; Extracellular Signal-Regulated MAP Kinases; Humans; Indoles; Lapatinib; Male; Melanoma; Mice, Inbred NOD; Mice, SCID; Niacinamide; Phenylurea Compounds; Phosphorylation; Pyrroles; Quinazolines; Sorafenib; Sulfonamides; Sunitinib; Vemurafenib; Xenograft Model Antitumor Assays | 2015 |
Antitubulinic effect of New Fluorazone Derivatives on Melanoma Cells.
Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Humans; Indoles; Melanoma; Molecular Structure; Pyrroles; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured | 2016 |
Design and synthesis of pyrrolobenzodiazepine-gallic hybrid agents as p53-dependent and -independent apoptogenic signaling in melanoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzodiazepines; Cell Line, Tumor; Female; Gallic Acid; Humans; Melanoma; Membrane Potential, Mitochondrial; Mice, Inbred ICR; Mitochondria; Models, Molecular; Pyrroles; Reactive Oxygen Species; Signal Transduction; Skin; Skin Neoplasms; Tumor Suppressor Protein p53 | 2016 |
Use of a MCL-1 inhibitor alone to de-bulk melanoma and in combination to kill melanoma initiating cells.
Topics: Animals; Antineoplastic Agents; Bcl-2-Like Protein 11; Biphenyl Compounds; Cell Line, Tumor; Cell Self Renewal; Cell Survival; Disease Models, Animal; Drug Synergism; Female; Gene Knockout Techniques; Humans; Melanocytes; Melanoma; Mice; Mutation; Myeloid Cell Leukemia Sequence 1 Protein; Neoplastic Stem Cells; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Xenograft Model Antitumor Assays | 2017 |
Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Enzyme Inhibitors; Everolimus; Humans; Isoquinolines; Mechanistic Target of Rapamycin Complex 1; Melanoma; Mice; Piperazines; Protein Kinase C; Proto-Oncogene Proteins c-mdm2; Pyrroles; Quinazolines; Tumor Suppressor Protein p53; Uveal Neoplasms; Xenograft Model Antitumor Assays | 2016 |
GLI inhibitor GANT61 kills melanoma cells and acts in synergy with obatoclax.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; GTP Phosphohydrolases; Humans; Indoles; Kruppel-Like Transcription Factors; Melanoma; Membrane Proteins; Mutation; Nuclear Proteins; Proto-Oncogene Proteins B-raf; Pyridines; Pyrimidines; Pyrroles; Zinc Finger Protein Gli2 | 2016 |
Tumor-targeted delivery of sunitinib base enhances vaccine therapy for advanced melanoma by remodeling the tumor microenvironment.
Topics: Animals; Antineoplastic Agents; Calcium Phosphates; Cancer Vaccines; Cell Line, Tumor; Cell Survival; Cytokines; Female; Immunotherapy, Active; Indoles; Melanoma; Membrane Proteins; Mice, Inbred C57BL; Micelles; Oligodeoxyribonucleotides; Peptide Fragments; Polymers; Proto-Oncogene Proteins c-akt; Pyrroles; STAT3 Transcription Factor; Sunitinib; Tumor Burden; Tumor Microenvironment | 2017 |
P21-activated kinase 1 regulates resistance to BRAF inhibition in human cancer cells.
Topics: Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Indoles; Melanoma; Molecular Targeted Therapy; p21-Activated Kinases; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrroles; rac1 GTP-Binding Protein; Sulfonamides; Vemurafenib | 2017 |
Secondary erythrocytosis produced by the tyrosine kinase inhibitors sunitinib and sorafenib.
Topics: Aged, 80 and over; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Hepatocellular; Carcinoma, Renal Cell; Female; Humans; Indoles; Kidney Neoplasms; Liver Neoplasms; Melanoma; Middle Aged; Niacinamide; Phenylurea Compounds; Polycythemia; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrroles; Sorafenib; Sunitinib | 2008 |
Pathological activation of KIT in metastatic tumors of acral and mucosal melanomas.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Humans; Indoles; Male; Melanoma; Middle Aged; Mucous Membrane; Mutation; Neoplasm Metastasis; Phosphorylation; Proto-Oncogene Proteins c-kit; Pyrroles; Skin Neoplasms; Stem Cell Factor; Sunitinib | 2009 |
Endothelin receptor B antagonists decrease glioma cell viability independently of their cognate receptor.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Ciprofloxacin; DNA Damage; Endothelin B Receptor Antagonists; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Humans; Isoquinolines; Melanoma; Oligonucleotide Array Sequence Analysis; Pyrroles; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; RNA, Small Interfering | 2008 |
Autocrine amplification loop in statin-induced apoptosis of human melanoma cells.
Topics: Antineoplastic Agents; Apoptosis; Atorvastatin; Autocrine Communication; Biological Factors; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Enzyme Activation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Melanoma; Pyridines; Pyrroles; Simvastatin; Time Factors | 2009 |
Human melanoma cells under endoplasmic reticulum stress are more susceptible to apoptosis induced by the BH3 mimetic obatoclax.
Topics: Antiviral Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Blotting, Western; Endoplasmic Reticulum; Enzyme Inhibitors; Humans; Immunoprecipitation; Indoles; Melanoma; Membrane Potential, Mitochondrial; Myeloid Cell Leukemia Sequence 1 Protein; Oxidative Stress; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; RNA, Small Interfering; Thapsigargin; Tumor Cells, Cultured; Tunicamycin | 2009 |
Pivotal roles of snail inhibition and RKIP induction by the proteasome inhibitor NPI-0052 in tumor cell chemoimmunosensitization.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cisplatin; Humans; Lactones; Leupeptins; Male; Melanoma; Membrane Potential, Mitochondrial; NF-kappa B; Phosphatidylethanolamine Binding Protein; Prostatic Neoplasms; Proteasome Inhibitors; Proto-Oncogene Proteins c-raf; Pyrazines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Snail Family Transcription Factors; TNF-Related Apoptosis-Inducing Ligand; Transcription Factors; Transfection; Tumor Cells, Cultured | 2009 |
Synthesis of pyrrolo[2,3-d]pyrimidine derivatives and their antiproliferative activity against melanoma cell line.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Melanoma; Molecular Structure; Pyrimidines; Pyrroles; Stereoisomerism; Structure-Activity Relationship | 2009 |
RT-PCR-based tyrosine kinase display profiling of canine melanoma: IGF-1 receptor as a potential therapeutic target.
Topics: Animals; Cell Line, Tumor; Dog Diseases; Dogs; Humans; Melanoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Skin Neoplasms | 2010 |
Protease-activated receptor-1 (PAR-1) promotes the motility of human melanomas and is associated to their metastatic phenotype.
Topics: Animals; Cell Line, Tumor; Cell Movement; Disease Progression; Humans; Melanoma; Mice; Mice, SCID; Neoplasm Metastasis; Pyrroles; Quinazolines; Receptor, PAR-1; Skin Neoplasms | 2010 |
Triple molecular target approach to selective melanoma cytotoxicity.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Catalytic Domain; Cell Line, Tumor; Humans; IMP Dehydrogenase; Lung Neoplasms; Melanoma; Mice; Mice, SCID; Models, Molecular; Phenylalanine; Pyrroles; Quantitative Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2010 |
Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Diamines; Indoles; Male; Melanoma; Mice; Mice, Nude; Molecular Structure; Phosphorylation; Pyrimidines; Pyrimidinones; Pyrroles; Structure-Activity Relationship; Vascular Endothelial Growth Factor Receptor-2 | 2010 |
Chiral 6-hydroxymethyl-1H,3H-pyrrolo[1,2-c]thiazoles: novel antitumor DNA monoalkylating agents.
Topics: Adenocarcinoma; Antineoplastic Agents, Alkylating; Breast Neoplasms; Cell Line, Tumor; Colorectal Neoplasms; DNA; Drug Screening Assays, Antitumor; Female; Humans; Melanoma; Pyrroles; Thiazoles | 2010 |
Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands.
Topics: Aging; Animals; Aorta; Cell Line; Cell Movement; Endothelial Cells; Hindlimb; Humans; Immunity, Innate; Inflammation; Ischemia; Ligands; Melanoma; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Neovascularization, Pathologic; Neovascularization, Physiologic; Oxidation-Reduction; Oxidative Stress; Platelet Endothelial Cell Adhesion Molecule-1; Propionates; Pyrroles; rac1 GTP-Binding Protein; Receptors, Scavenger; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptor 4; Vascular Endothelial Growth Factor A; Wound Healing | 2010 |
VEGFR1 and PKCα signaling control melanoma vasculogenic mimicry in a VEGFR2 kinase-independent manner.
Topics: Animals; Cell Line, Tumor; Female; Humans; Indoles; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Protein Kinase C-alpha; Pyrroles; RNA, Small Interfering; Signal Transduction; Skin Neoplasms; Transfection; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2011 |
Inhibition of activated receptor tyrosine kinases by Sunitinib induces growth arrest and sensitizes melanoma cells to Bortezomib by blocking Akt pathway.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Chromones; Humans; Indoles; Melanoma; Morpholines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazines; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor alpha; RNA, Small Interfering; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor Receptor-2 | 2012 |
Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines.
Topics: Animals; Antineoplastic Agents; Benzenesulfonates; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Melanoma; Mice; Niacinamide; Phenylurea Compounds; Pyridines; Pyrroles; Skin Neoplasms; Sorafenib; Structure-Activity Relationship | 2011 |
Exceptional production of both prodigiosin and cycloprodigiosin as major metabolic constituents by a novel marine bacterium, Zooshikella rubidus S1-1.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor; Chromatography, Liquid; DNA, Bacterial; DNA, Ribosomal; Gammaproteobacteria; Genotype; Humans; Indoles; Mass Spectrometry; Melanoma; Molecular Sequence Data; Phenotype; Phylogeny; Pigments, Biological; Prodigiosin; Pyrroles; Republic of Korea; RNA, Bacterial; RNA, Ribosomal, 16S; Seawater | 2011 |
A DC-81-indole conjugate agent suppresses melanoma A375 cell migration partially via interrupting VEGF production and stromal cell-derived factor-1α-mediated signaling.
Topics: Antineoplastic Agents; Apoptosis; Benzodiazepines; Blotting, Western; Caspases; Cell Cycle; Cell Line, Tumor; Cell Movement; Chemokine CXCL12; Flow Cytometry; Humans; Indoles; Melanoma; Organophosphorus Compounds; Protein Kinase Inhibitors; Pyrroles; Signal Transduction; Vascular Endothelial Growth Factor A | 2011 |
PRKX, TTBK2 and RSK4 expression causes Sunitinib resistance in kidney carcinoma- and melanoma-cell lines.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Gene Expression Profiling; Humans; Indoles; Kidney Neoplasms; Melanoma; Protein Serine-Threonine Kinases; Pyrroles; Ribosomal Protein S6 Kinases, 90-kDa; RNA Interference; RNA, Small Interfering; Sunitinib | 2012 |
Identification of dual mTORC1 and mTORC2 inhibitors in melanoma cells: prodigiosin vs. obatoclax.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Indoles; Insulin Receptor Substrate Proteins; Mechanistic Target of Rapamycin Complex 1; Melanoma; Multiprotein Complexes; Phosphatidylinositol 3-Kinases; Prodigiosin; Proteins; Proto-Oncogene Proteins c-akt; Pyrroles; Ribosomal Protein S6 Kinases, 70-kDa; TOR Serine-Threonine Kinases; Transcription Factors | 2012 |
Sunitinib therapy for melanoma patients with KIT mutations.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Gene Amplification; Gene Expression; Humans; Indoles; Male; Melanoma; Middle Aged; Mutation; Proto-Oncogene Proteins c-kit; Pyrroles; Sunitinib; Survival Analysis; Treatment Outcome | 2012 |
Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. Part 2.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Humans; Melanoma; Pyridines; Pyrroles; Structure-Activity Relationship | 2012 |
Protein kinase C inhibitor AEB071 targets ocular melanoma harboring GNAQ mutations via effects on the PKC/Erk1/2 and PKC/NF-κB pathways.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; G1 Phase Cell Cycle Checkpoints; Gene Expression; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Isoenzymes; MAP Kinase Signaling System; Melanoma; NF-kappa B; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Pyrroles; Quinazolines; Uveal Neoplasms | 2012 |
Sunitinib treatment does not improve blood supply but induces hypoxia in human melanoma xenografts.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Basement Membrane; Blood Vessels; Cell Hypoxia; Female; Humans; Indoles; Melanoma; Mice; Mice, Nude; Neovascularization, Pathologic; Pyrroles; Spheroids, Cellular; Sunitinib; Tumor Burden; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2012 |
Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells.
Topics: Acetylation; Cell Line, Tumor; Cell Proliferation; DNA-Directed RNA Polymerases; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Interleukin-8; Melanoma; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-jun; Pyrroles; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factor TFIIB; Transcription, Genetic; Uveal Neoplasms | 2013 |
DC-81-enediyne induces apoptosis of human melanoma A375 cells: involvement of the ROS, p38 MAPK, and AP-1 signaling pathways.
Topics: Anthraquinones; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; DNA; DNA Damage; Enediynes; Enzyme Inhibitors; Humans; Imidazoles; MAP Kinase Signaling System; Melanoma; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Poly(ADP-ribose) Polymerases; Pyridines; Pyrroles; Reactive Oxygen Species; Transcription Factor AP-1 | 2013 |
Quantitative relationships between pigment-related mRNA and biochemical melanoma markers in melanoma cell lines.
Topics: Antigens, Neoplasm; Biomarkers, Tumor; Gene Expression Profiling; Humans; Intramolecular Oxidoreductases; MART-1 Antigen; Melanins; Melanoma; Membrane Glycoproteins; Monophenol Monooxygenase; Neoplasm Proteins; Neoplastic Cells, Circulating; Nerve Growth Factors; Oxidoreductases; Pigmentation; Polymerase Chain Reaction; Proteins; Pyrroles; RNA, Messenger; RNA, Neoplasm; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Tumor Cells, Cultured; Tyrosine | 2002 |
Synthesis of novel C2-aryl pyrrolobenzodiazepines (PBDs) as potential antitumour agents.
Topics: Antineoplastic Agents; Benzodiazepines; Cell Division; Drug Screening Assays, Antitumor; Female; Humans; Male; Melanoma; Ovarian Neoplasms; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
Isoprenylation is necessary for the full invasive potential of RhoA overexpression in human melanoma cells.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Biocompatible Materials; Cell Movement; Collagen; Drug Combinations; Gene Expression Regulation, Neoplastic; Heptanoic Acids; Humans; Laminin; Melanoma; Neoplasm Invasiveness; Neoplasm Metastasis; Protein Prenylation; Protein Processing, Post-Translational; Proteoglycans; Pyrroles; rhoA GTP-Binding Protein; Signal Transduction; Skin Neoplasms; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
Biological evaluation of an antibiotic DC-81-indole conjugate agent in human melanoma cell lines.
Topics: Antibiotics, Antineoplastic; Benzodiazepines; DNA; Humans; Melanoma; Organophosphorus Compounds; Pyrroles; Tumor Cells, Cultured | 2003 |
Atorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human melanoma cells.
Topics: Animals; Atorvastatin; Cell Movement; Green Fluorescent Proteins; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Immunoblotting; Immunohistochemistry; Luciferases; Luminescent Proteins; Melanoma; Mice; Mice, SCID; Microscopy, Fluorescence; Neoplasm Invasiveness; Neoplasm Metastasis; Plasmids; Protein Processing, Post-Translational; Pyrroles; ras Proteins; rho GTP-Binding Proteins; rhoC GTP-Binding Protein; Serum Response Factor; Subcellular Fractions; Time Factors; Tumor Cells, Cultured | 2003 |
Relationship between antiapoptotic molecules and metastatic potency and the involvement of DNA-dependent protein kinase in the chemosensitization of metastatic human cancer cells by epidermal growth factor receptor blockade.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Line, Tumor; DNA-Activated Protein Kinase; DNA-Binding Proteins; Drug Synergism; Electrophoretic Mobility Shift Assay; ErbB Receptors; Etoposide; Genes, MDR; Humans; Indicators and Reagents; Melanoma; Neoplasm Metastasis; Nuclear Proteins; Protein Serine-Threonine Kinases; Pyrimidines; Pyrroles; Radiation-Sensitizing Agents; Rats | 2004 |
Design, synthesis, and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugates as anticancer agents.
Topics: Antineoplastic Agents; Apoptosis; Benzodiazepines; Cell Cycle; Cell Line, Tumor; DNA; Drug Design; Drug Screening Assays, Antitumor; Humans; Indoles; Melanoma; Membrane Potentials; Mitochondrial Membranes; Models, Molecular; Pyrroles; Structure-Activity Relationship | 2006 |
PTCA determination in human hair: reliability and analytical aspects.
Topics: Chromatography, High Pressure Liquid; Female; Hair; Humans; Male; Melanoma; Pyrroles; Reproducibility of Results; Risk | 2006 |
Is 2,3,5-pyrroletricarboxylic acid in hair a better risk indicator for melanoma than traditional epidemiologic measures for skin phenotype?
Topics: Adult; Aged; Bayes Theorem; Case-Control Studies; Hair; Humans; Male; Melanins; Melanoma; Middle Aged; Phenotype; Pyrroles; Risk Factors; Skin Neoplasms; Spectroscopy, Near-Infrared | 2007 |
Rosmarinic acid induces melanogenesis through protein kinase A activation signaling.
Topics: Animals; Carbazoles; Cell Line, Tumor; Cinnamates; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Depsides; Enzyme Activation; Indoles; Isoquinolines; Melanins; Melanoma; Mice; Monophenol Monooxygenase; Oncogene Protein v-akt; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrroles; Rosmarinic Acid; Signal Transduction; Sulfonamides | 2007 |
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Boronic Acids; Bortezomib; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Drug Resistance, Neoplasm; Humans; Indoles; Melanoma; Mice; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyrroles | 2007 |
Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: synthesis, DNA interaction, cytotoxicity and differential cellular localization.
Topics: Benzodiazepines; Cell Nucleus; Cell Survival; Cytoplasm; DNA; Female; Humans; Melanoma; Microscopy, Fluorescence; Molecular Structure; Ovarian Neoplasms; Pyrroles; Tumor Cells, Cultured | 2008 |
Molecule of the month. Elesclomol and obatoclax mesylate.
Topics: Antineoplastic Agents; Controlled Clinical Trials as Topic; Humans; Hydrazines; Indoles; Melanoma; Neoplasm Metastasis; Neoplasms; Pyrroles | 2008 |
Off-label uses of sorafenib and sunitinib.
Topics: Adenocarcinoma; Angiogenesis Inhibitors; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase III as Topic; Digestive System Neoplasms; Drug Approval; Female; Gastrointestinal Stromal Tumors; Head and Neck Neoplasms; Humans; Indoles; Male; Melanoma; Neoplasms, Squamous Cell; Product Labeling; Pyridines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome; United States; United States Food and Drug Administration | 2008 |
Melanins in IGR 1 melanoma cells.
Topics: Chromatography, Liquid; Cysteinyldopa; Dicarboxylic Acids; Humans; Hydrolysis; Mass Spectrometry; Melanins; Melanoma; Monophenol Monooxygenase; Neoplasm Proteins; Oxidation-Reduction; Potassium Permanganate; Pyrroles; Sulfur; Thiazoles; Tumor Cells, Cultured; Tyrosine | 1994 |
Structure-activity studies of benzimidazole-based DNA-cleaving agents. Comparison of benzimidazole, pyrrolobenzimidazole, and tetrahydropyridobenzimidazole analogues.
Topics: Alkylation; Antineoplastic Agents; Base Sequence; Benzimidazoles; DNA; Leukemia; Magnetic Resonance Spectroscopy; Melanoma; Molecular Sequence Data; Molecular Structure; Molecular Weight; Pyridines; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
Macrophage-melanoma cell heterokaryons. IV. Unmasking the macrophage-specific membrane receptor.
Topics: Animals; Bromine; Carcinoma, Ehrlich Tumor; Cell Fusion; Cell Membrane; Cell Nucleus; Cells, Cultured; Chick Embryo; Cycloheximide; Enzymes; Erythrocytes; Histocytochemistry; Immunoglobulin G; Immunoglobulins; Macrophages; Melanoma; Methods; Mice; Microscopy, Phase-Contrast; Phagocytosis; Pyrimidines; Pyrroles; Radiation Effects; Ribonucleosides; RNA, Neoplasm; Trypsin; Ultraviolet Rays | 1971 |