Page last updated: 2024-08-18

pyrroles and Liver Diseases

pyrroles has been researched along with Liver Diseases in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (30.56)	18.7374
1990's	1 (2.78)	18.2507
2000's	9 (25.00)	29.6817
2010's	7 (19.44)	24.3611
2020's	8 (22.22)	2.80

Authors

Authors	Studies
Boinpally, R; Lu, K	1
Greenberg, J; Healey, JH; Hsu, C; LaCreta, F; Lasseter, KC; Marbury, TC; Stacchiotti, S; Tap, WD; Xu, LA; Zahir, H	1
Hayes, H; Lawitz, E; Momin, T; Parmar, D; Patel, H; Shaikh, F; Swint, K	1
Inoue, M; Ishizuka, H; Ishizuka, T; Kato, M; Kurata, A; Nakatsu, T; Nishikawa, Y; Shimizu, T; Yoshida, T	1
Barbour, AM; Chen, X; Cimino, E; Epstein, N; Leonetti-Whalen, C; Punwani, N; Rockich, K; Yeleswaram, S; Zhou, G	1
Boinpally, R; Borbridge, L; Butler, M; Jakate, A; Periclou, A	1
Chen, X; Epstein, N; Ji, T; Overholt, H; Punwani, N; Rockich, K; Wang, P; Yeleswaram, S	1
Hu, K; Huang, J; Jiang, R; Li, L; Lin, L; Lv, X; Shen, Y; Tang, L; Wan, J; Yang, Y; Zhang, L; Zhou, H	1
Acikgoz, E; Aktug, H; Demir, K; Duzagac, F; Guven, U; Oktem, G; Oltulu, F; Yavasoglu, A; Yigitturk, G	1
Chebib, FT; Constans, MM; Pellegrini, L; Torres, VE; Wang, X	1
Chen, X; Dai, X; Hou, X; Yang, Y; Zhang, Y; Zhong, D	1
Chang, CH; Chang, YC; Chuang, LM; Lee, YC; Lin, JW; Liu, YC	1
Alvey, CW; Chan, G; Krishnaswami, S; Lamba, M; Lawendy, N; Wang, R	1
González-Gallego, J; Mauriz, JL; Tuñón, MJ	1
Amura, CR; Barry, NP; Brodsky, KS; Doctor, RB; McWilliams, RR	1
Cadamuro, M; Fabris, L; Fiorotto, R; Lecchi, S; Okolicsanyi, S; Somlo, S; Spirli, C; Strazzabosco, M; Tian, X	1
Bonkovsky, HL; Russo, MW; Scobey, M	1
Bello, CL; Garrett, M; Ryan, B; Sherman, L; Smeraglia, J; Toh, M	1
Chin, YW; Kim, J; Kim, SH; Kim, YB; Kim, YC; Lim, SW; Shin, DY; Suh, YG	1
HULUBEI, P; MIHAI, C; OANCEA, C	1
CHISOLM, JJ	1
Boiadjiev, SE; Lightner, DA; McDonagh, AF; Norona, WS; Woydziak, ZR	1
Becx, MC; Kuypers, KC; Seldenrijk, CA; Stolk, MF	1
Andrade, RJ; Barriocanal, A; Borraz, Y; Costa, J; Durán, JA; Fernández, MC; García-Cortés, M; García-Muņoz, B; Guarner, C; Hidalgo, R; Kaplowitz, N; Lucena, MI; Muņoz-Yagüe, T; Pachkoria, K; Pelaez, G; Planas, R; Rodrigo, L; Romero-Gomez, M; Salmerón, J	1
Alsheikh-Ali, AA; Karas, RH	1
Amura, CR; Brodsky, KS; Doctor, RB; Gattone, VH; Groff, R; Voelkel, NF	1
Grenier, A; Meister, A; New, MI; Rifkind, AB; Sassa, S; Starkman, H; Steinherz, PG; Stoner, E; Wellner, D; Wellner, VP	1
Fevery, J	1
Moravec, M	1
Chiu, HF; Lee, SG; Lin, CC; Lin, JM; Yang, JJ	1
Ford, EJ	1
Richard, JL	1
Allen, JR; Chesney, CF	1
Gross, SR; Hutton, JJ	1
Goldberg, A	1
McMillin, JM; Watson, CJ; Zimmerman, TS	1

Reviews

5 review(s) available for pyrroles and Liver Diseases

Article	Year
Apoptotic signaling pathways as a target for the treatment of liver diseases. Mini reviews in medicinal chemistry, 2008, Volume: 8, Issue:14 Topics: Animals; Apoptosis; Atorvastatin; Gliotoxin; Heptanoic Acids; Humans; Liver Diseases; Molecular Conformation; Pyrroles; Signal Transduction; Ursodeoxycholic Acid	2008
Drug-induced liver injury associated with statins. Seminars in liver disease, 2009, Volume: 29, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Atorvastatin; Autoimmunity; Biomarkers; Biopsy; Chemical and Drug Induced Liver Injury; Chronic Disease; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Liver; Liver Diseases; Male; Middle Aged; Practice Guidelines as Topic; Pyrroles; Risk Assessment; Treatment Outcome; Young Adult	2009
PEDIATRIC ASPECTS OF THE PORPHYRIAS. The Journal of pediatrics, 1964, Volume: 64 Topics: Blood Chemical Analysis; Child; Erythropoiesis; Feces; Genetics, Medical; Glycine; Humans; Liver Diseases; Porphyrias; Porphyrins; Pyrroles	1964
[The conjugation of bilirubin: clinico-experimental studies]. Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie, 1980, Volume: 42, Issue:5-6 Topics: Animals; Bile Pigments; Bilirubin; Chromatography, Thin Layer; Crigler-Najjar Syndrome; Erythropoiesis; Gilbert Disease; Glucuronates; Hemolysis; Humans; Hyperbilirubinemia; Hyperbilirubinemia, Hereditary; Infant, Newborn; Kidney; Liver; Liver Diseases; Microsomes, Liver; Pyrroles; Tetrapyrroles	1980
Mycotoxin photosensitivity. Journal of the American Veterinary Medical Association, 1973, Dec-01, Volume: 163, Issue:11 Topics: Animal Feed; Animals; Cattle; Cattle Diseases; Chemical and Drug Induced Liver Injury; Cholestasis; Eczema; Indoles; Liver Diseases; Medicago sativa; Mitosporic Fungi; Mycotoxins; Photosensitivity Disorders; Pyrazines; Pyrroles; Sheep; Sheep Diseases; United States	1973

Trials

6 trial(s) available for pyrroles and Liver Diseases

Article	Year
Single-Dose Pharmacokinetics and Safety of Ubrogepant in Adults With Hepatic Impairment: Results From an Open-Label, Phase 1 Trial. Clinical pharmacology in drug development, 2022, Volume: 11, Issue:7 Topics: Adult; Humans; Liver Diseases; Migraine Disorders; Pyridines; Pyrroles	2022
Pharmacokinetics and Safety of Single-Dose Esaxerenone in Japanese Subjects with Mild to Moderate Hepatic Impairment. Advances in therapy, 2020, Volume: 37, Issue:1 Topics: Administration, Oral; Adult; Aged; Area Under Curve; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Humans; Japan; Liver Diseases; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Pyrroles; Severity of Illness Index; Sulfones	2020
Single-Dose Pharmacokinetics and Safety of Atogepant in Adults With Hepatic Impairment: Results From an Open-Label, Phase 1 Trial. Clinical pharmacology in drug development, 2021, Volume: 10, Issue:7 Topics: Administration, Oral; Aged; Calcitonin Gene-Related Peptide Receptor Antagonists; Female; Half-Life; Humans; Liver Diseases; Male; Middle Aged; Piperidines; Pyridines; Pyrroles; Severity of Illness Index; Spiro Compounds	2021
Evaluation of the pharmacokinetics of pemigatinib in patients with impaired hepatic or renal function. British journal of clinical pharmacology, 2022, Volume: 88, Issue:1 Topics: Area Under Curve; Chromatography, Liquid; Humans; Kidney; Kidney Failure, Chronic; Liver Diseases; Morpholines; Pyrimidines; Pyrroles; Renal Insufficiency; Tandem Mass Spectrometry	2022
The effect of mild and moderate hepatic impairment on the pharmacokinetics of tofacitinib, an orally active Janus kinase inhibitor. Clinical pharmacology in drug development, 2014, Volume: 3, Issue:6 Topics: Administration, Oral; Adult; Area Under Curve; Biotransformation; Cytochrome P-450 CYP2C19; Female; Florida; Genotype; Humans; Janus Kinase Inhibitors; Liver; Liver Diseases; Liver Function Tests; Male; Metabolic Clearance Rate; Middle Aged; Pharmacogenetics; Pharmacogenomic Variants; Phenotype; Piperidines; Pyrimidines; Pyrroles; Severity of Illness Index	2014
Pharmacokinetics of sunitinib malate in subjects with hepatic impairment. Cancer chemotherapy and pharmacology, 2010, Volume: 66, Issue:4 Topics: Aged; Alanine Transaminase; Antineoplastic Agents; Area Under Curve; Endpoint Determination; Female; Humans; Indoles; Liver Diseases; Liver Function Tests; Male; Middle Aged; Pyrroles; Sample Size; Sunitinib	2010

Other Studies

25 other study(ies) available for pyrroles and Liver Diseases

Article	Year
Effect of Mild and Moderate Hepatic Impairment (Defined by Child-Pugh Classification and National Cancer Institute Organ Dysfunction Working Group Criteria) on Pexidartinib Pharmacokinetics. Journal of clinical pharmacology, 2022, Volume: 62, Issue:8 Topics: Aminopyridines; Area Under Curve; Humans; Liver Diseases; Multiple Organ Failure; National Cancer Institute (U.S.); Neoplasms; Pyrroles; United States	2022
Pharmacokinetics and Safety Evaluation of Single-Dose Saroglitazar Magnesium in Subjects with Hepatic Impairment. Clinical pharmacology in drug development, 2023, Volume: 12, Issue:12 Topics: Area Under Curve; Humans; Liver Diseases; Phenylpropionates; Pyrroles	2023
Effect of Hepatic Impairment on the Pharmacokinetics of Itacitinib. Journal of clinical pharmacology, 2021, Volume: 61, Issue:7 Topics: Acetonitriles; Adult; Aged; Area Under Curve; Body Mass Index; Female; Humans; Janus Kinase Inhibitors; Liver Diseases; Liver Function Tests; Male; Metabolic Clearance Rate; Middle Aged; Patient Acuity; Protein Binding; Pyrazoles; Pyrimidines; Pyrroles	2021
Activation of PKM2 metabolically controls fulminant liver injury via restoration of pyruvate and reactivation of CDK1. Pharmacological research, 2021, Volume: 172 Topics: Animals; Apoptosis; CDC2 Protein Kinase; Galactosamine; Hepatocytes; Lipopolysaccharides; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Pyridazines; Pyrroles; Pyruvate Kinase; Pyruvates; Pyruvic Acid	2021
Repression of the Notch pathway prevents liver damage in streptozotocin-induced diabetic mice. Folia histochemica et cytobiologica, 2017, Volume: 55, Issue:3 Topics: Animals; Diabetes Mellitus, Experimental; Down-Regulation; Immunohistochemistry; Indoles; Jagged-1 Protein; Liver; Liver Diseases; Male; Mice; Pyrroles; Receptor, Notch1; Signal Transduction; Sunitinib	2017
Effect of a Vasopressin V2 Receptor Antagonist on Polycystic Kidney Disease Development in a Rat Model. American journal of nephrology, 2019, Volume: 49, Issue:6 Topics: Administration, Oral; Animals; Antidiuretic Hormone Receptor Antagonists; Benzamides; Creatinine; Cysts; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Kidney; Liver; Liver Diseases; Mutation; Organ Size; Polycystic Kidney, Autosomal Dominant; Pyrroles; Rats; Receptors, Cell Surface; Receptors, Vasopressin	2019
Simultaneous determination of imrecoxib and its two active metabolites in plasma of hepatic impairment patients by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2019, Aug-01, Volume: 1122-1123 Topics: Chromatography, Liquid; Humans; Limit of Detection; Linear Models; Liver Diseases; Pyrroles; Reproducibility of Results; Sulfides; Tandem Mass Spectrometry	2019
Severe hepatic injury associated with different statins in patients with chronic liver disease: a nationwide population-based cohort study. Journal of gastroenterology and hepatology, 2015, Volume: 30, Issue:1 Topics: Adult; Aged; Atorvastatin; Chemical and Drug Induced Liver Injury; Chronic Disease; Cohort Studies; Follow-Up Studies; Heptanoic Acids; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Liver Diseases; Male; Middle Aged; Pyrroles; Risk; Severity of Illness Index; Taiwan; Time Factors	2015
Liver cyst cytokines promote endothelial cell proliferation and development. Experimental biology and medicine (Maywood, N.J.), 2009, Volume: 234, Issue:10 Topics: Animals; Cell Proliferation; Cells, Cultured; Cyst Fluid; Cysts; Cytokines; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Humans; Indoles; Liver Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Polycystic Kidney, Autosomal Dominant; Pyrroles; TRPP Cation Channels; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2009
ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice. Gastroenterology, 2010, Volume: 138, Issue:1 Topics: Animals; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cysts; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Liver Diseases; MAP Kinase Signaling System; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phenotype; Phosphorylation; Proliferating Cell Nuclear Antigen; Protein Kinase Inhibitors; Pyrroles; Repressor Proteins; TRPP Cation Channels; Tumor Suppressor Proteins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2010
Hepatoprotective pyrrole derivatives of Lycium chinense fruits. Bioorganic & medicinal chemistry letters, 2003, Jan-06, Volume: 13, Issue:1 Topics: Animals; Carbon Tetrachloride; Dose-Response Relationship, Drug; Drug Antagonism; Fruit; Hepatocytes; Liver Diseases; Lycium; Magnetic Resonance Spectroscopy; Plants, Medicinal; Protective Agents; Pyrroles; Rats; Structure-Activity Relationship	2003
[Clinical value of urinary pentdyopent and porphobilinogen in patients with hepatic and renal diseases]. Medicina interna, 1963, Volume: 15 Topics: Hemoglobins; Humans; Kidney Diseases; Liver Diseases; Porphobilinogen; Porphyrins; Pyrroles	1963
Synthesis and hepatic transport of strongly fluorescent cholephilic dipyrrinones. The Journal of organic chemistry, 2005, Oct-14, Volume: 70, Issue:21 Topics: Animals; Bile; Bilirubin; Colchicine; Drug Evaluation, Preclinical; Feasibility Studies; Fluorescent Dyes; Liver; Liver Diseases; Male; Mitochondrial Proteins; Pyrimidinones; Pyrroles; Rats; Rats, Gunn; Rats, Sprague-Dawley; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Spectrometry, Fluorescence; Sulfonic Acids; Urine	2005
Severe hepatic side effects of ezetimibe. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2006, Volume: 4, Issue:7 Topics: Anticholesteremic Agents; Atorvastatin; Azetidines; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Ezetimibe; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Liver Diseases; Male; Middle Aged; Pyrroles; Transaminases	2006
Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry. Hepatology (Baltimore, Md.), 2006, Volume: 44, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Amoxicillin-Potassium Clavulanate Combination; Atorvastatin; Azepines; Captopril; Cardiovascular Agents; Central Nervous System Agents; Chemical and Drug Induced Liver Injury; Chronic Disease; Disease Progression; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Heptanoic Acids; Humans; Liver; Liver Diseases; Male; Middle Aged; Pyrroles; Registries; Spain	2006
Safety of lovastatin/extended release niacin compared with lovastatin alone, atorvastatin alone, pravastatin alone, and simvastatin alone (from the United States Food and Drug Administration adverse event reporting system). The American journal of cardiology, 2007, Feb-01, Volume: 99, Issue:3 Topics: Adverse Drug Reaction Reporting Systems; Atorvastatin; Chemical and Drug Induced Liver Injury; Drug Prescriptions; Drug Therapy, Combination; Dyslipidemias; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Liver Diseases; Lovastatin; Niacin; Pravastatin; Prevalence; Pyrroles; Retrospective Studies; Rhabdomyolysis; Risk Factors; Simvastatin; United States; United States Food and Drug Administration	2007
VEGF receptor inhibition blocks liver cyst growth in pkd2(WS25/-) mice. American journal of physiology. Cell physiology, 2007, Volume: 293, Issue:1 Topics: Animals; Cell Proliferation; Cells, Cultured; Cyst Fluid; Cysts; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial Cells; Indoles; Liver; Liver Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Polycystic Kidney, Autosomal Dominant; Protein Kinase Inhibitors; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Time Factors; TRPP Cation Channels; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2	2007
Biochemical studies of a patient with hereditary hepatorenal tyrosinemia: evidence of glutathione deficiency. Pediatric research, 1984, Volume: 18, Issue:12 Topics: Erythrocytes; Fanconi Syndrome; Female; Glutathione; Heme; Humans; Infant; Liver; Liver Diseases; Mass Spectrometry; Mixed Function Oxygenases; Phosphates; Pyrroles; Rickets; Syndrome; Tyrosine	1984
[Origin and pathogenesis of polymeric dipyrrilmethenes]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1980, Jul-15, Volume: 35, Issue:14 Topics: Anemia, Megaloblastic; Benzopyrans; Bile; Cholestasis; Common Bile Duct; Duodenum; Hemolysis; Humans; Leukemia; Liver Diseases; Pyrroles	1980
Evaluation of the anti-inflammatory and liver-protective effects of anoectochilus formosanus, ganoderma lucidum and gynostemma pentaphyllum in rats. The American journal of Chinese medicine, 1993, Volume: 21, Issue:1 Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Biopsy; Carbon Tetrachloride; Carrageenan; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Edema; Liver Diseases; Male; Pyrroles; Rats; Rats, Wistar	1993
Activity of gamma-glutamyl transpeptidase and other enzymes in the serum of sheep with liver or kidney damage. Journal of comparative pathology, 1974, Volume: 84, Issue:2 Topics: Alcohol Oxidoreductases; Animals; Arginase; Aspartate Aminotransferases; Bilirubin; Brain; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Female; gamma-Glutamyltransferase; Glutamate Dehydrogenase; Indoles; Intestine, Small; Kidney; Kidney Diseases; Ligation; Liver; Liver Diseases; Male; Mercury Poisoning; Muscles; Mycotoxins; Myocardium; Pancreas; Pyrazines; Pyrroles; Sheep; Sheep Diseases; Urea	1974
Effect of age on development of cor pulmonale in nonhuman primates following pyrrolizidine alkaloid intoxication. Experimental and molecular pathology, 1972, Volume: 17, Issue:2 Topics: Age Factors; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Enzymes; Female; Formaldehyde; Haplorhini; Hepatic Veins; Injections, Subcutaneous; Liver; Liver Diseases; Lung; Macaca; Male; Microsomes, Liver; Myocardium; Necrosis; Pulmonary Artery; Pulmonary Heart Disease; Pyrroles; Pyrrolizidine Alkaloids	1972
Chemical induction of hepatic porphyria in inbred strains of mice. Archives of biochemistry and biophysics, 1970, Volume: 141, Issue:1 Topics: Acyltransferases; Amino Acids; Animals; Chemical and Drug Induced Liver Injury; Feedback; Female; Genotype; Hydro-Lyases; Inbreeding; Levulinic Acids; Liver; Liver Diseases; Lyases; Mice; Porphyrias; Porphyrins; Propionates; Pyridines; Pyrroles; Succinates	1970
Diagnosis and treatment of the porphyrias. Proceedings of the Royal Society of Medicine, 1968, Volume: 61, Issue:2 Topics: Acute Disease; Amino Acids; Erythropoiesis; Feces; Female; Humans; Levulinic Acids; Liver Diseases; Male; Photosensitivity Disorders; Porphyrias; Porphyrins; Pyrroles; Skin Diseases; Skin Manifestations	1968
Onset of manifestations of hepatic porphyria in relation to the influence of female sex hormones. Archives of internal medicine, 1966, Volume: 118, Issue:3 Topics: Adult; Aged; Alkaline Phosphatase; Bilirubin; Blood; Estrogens; Female; Humans; In Vitro Techniques; Liver Diseases; Male; Menstruation Disturbances; Middle Aged; Neurologic Manifestations; Porphyrias; Porphyrins; Pregnancy; Pregnancy Complications; Pyrroles; Skin Manifestations; Sulfobromophthalein	1966