Compounds > pyrroles
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pyrroles and Leukemia

pyrroles has been researched along with Leukemia in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19902 (5.56)18.7374
1990's2 (5.56)18.2507
2000's14 (38.89)29.6817
2010's16 (44.44)24.3611
2020's2 (5.56)2.80

Authors

AuthorsStudies
Ahlert, H; Bhatia, S; Borkhardt, A; Breit, B; Günther, S; Hansen, FK; Hügle, M; Kraft, FB; Mishra, P; Schäker-Hübner, L; Schliehe-Diecks, J; Schöler, A; Warstat, R1
Bazinet, A; Bhalla, K; Borthakur, G; Curry, JL; Daver, N; Heberton, M; Kadia, T; Khoury, JD; Kim, K; Konopleva, M; Loghavi, S; Miller, D; Pemmaraju, N; Pierce, S; Wilson, NR1
Li, Z; Liang, F; Liu, Y; Shen, X; Sheng, H; Song, T; Xue, Z; Zhang, Z; Zhao, Y1
Ito, K; Koide, N; Komatsu, T; Naiki, Y; Odkhuu, E; Tsolmongyn, B; Yokochi, T; Yoshida, T1
Anderl, JL; Assaraf, YG; Cloos, J; Jansen, G; Kale, AJ; Kaspers, GJ; Moore, BS; Niewerth, D; Riethoff, LF; van Meerloo, J; Zweegman, S1
Hu, R; Li, J; Liu, Z; Miao, M; Yao, K1
Mazur, L; Opydo-Chanek, M1
Jackson, PJ; Mantaj, J; Rahman, KM; Thurston, DE1
Andreeff, M; Berger, M; Borthakur, G; Brandwein, J; Chang, H; Cheson, BD; Giles, F; Gupta, V; Kamel-Reid, S; Kantarjian, H; Koller, C; Minden, MD; O'Brien, S; Ravandi, F; Schimmer, AD; Schuh, A; Viallet, J; Yee, K1
Antico, G; Calogero, RA; Jordan, A; Lo Iacono, M; Platanias, LC; Sassano, A; Uddin, S1
Fuchs, O; Kuzelova, K; Marinov, I; Provaznikova, D; Spicka, I1
Desplat, V; Fabre, SB; Gay, A; Godde, F; Guillon, J; Jarry, C; Macky, G; Massip, S; Moreau, S; Mossalayi, D; Thiolat, D1
Garcia-Manero, G; Hu, Y; Jia, Y; Kadia, T; O'Brien, S; Tambaro, FP; Tong, W; Viallet, J; Wei, Y; Yang, H; Zhang, M1
Guo, ZJ; Wu, N; Xu, Y1
Basso, G; Bortolozzi, R; Brun, P; Castagliuolo, I; Ferlin, MG; Hamel, E; Viola, G1
Chandra, J; Debose, L; Hale, R; Macherla, VR; Manton, CA; Miller, CP; Palladino, MA; Potts, BC1
Fiedler, W; Wellbrock, J1
Amin, S; Awwad, A; Cheng, C; Daughdrill, G; Dewey, A; Doi, K; Krishnegowda, G; Li, R; Liu, X; Liu, Y; Loughran, TP; Manieri, W; Qin, Y; Schonbrunn, E; Sebti, S; Sung, SS; Wang, HG; Wu, H1
Claxton, D; Joudeh, J1
Berman, JN; Colpitts, J; Corkery, DP; Dellaire, G; Forrester, AM; McFarland, SA; Smithen, DA; Thompson, A1
Fang, W; Li, R; Qu, X; Quan, Z; Yang, SS1
Buchdunger, E; Fabbro, D; Forster, K; Hallek, M; Manley, PW; Mathes, R; Mitina, O; Moarefi, I; Simon, N; Warmuth, M1
BROWN, GB; CRESSWELL, RM; STRAUSS, T1
Campiani, G; Greene, LM; Lawler, M; Ledwidge, S; Mc Gee, MM; Nacci, V; Williams, DC; Zisterer, DM1
Bainbridge, T; Cherrington, JM; Heinrich, MC; McGreevey, L; O'Farrell, AM; Schittenhelm, M; Town, AR; Yee, KW1
Iwano, C; Matsuyama, K; Matzno, S; Nishikata, M; Yasuda, N1
Kiyoi, H1
Ikezoe, T; Koeffler, HP; Komatsu, N; Nishioka, C; Taguchi, H; Tasaka, T; Togitani, K; Yang, Y1
Ban, K; Chandra, J; Dujka, ME; McConkey, DJ; Miller, CP; Munsell, M; Palladino, M1
Ikezoe, T; Koeffler, HP; Komatsu, N; Nishioka, C; Takeshita, A; Taniguchi, A; Togitani, K; Yang, J; Yokoyama, A1
Andreeff, M; Bornmann, W; Contractor, R; Estrov, Z; Harris, D; Kantarjian, H; Konopleva, M; Samudio, I; Tsao, T; Viallet, J; Watt, J1
Andreeff, M; Jin, L; Konopleva, M; McQueen, T; Ohsaka, A; Tabe, Y; Watt, J; Xu, Y1
Moravec, M1
Heileman, MJ; Islam, I; Schulz, WG; Skibo, EB1
Aiello, E; Almerico, AM; Barraja, P; Cirrincione, G; Dattolo, G; Diana, P; Grimaudo, S; Mingola, F1
Bailly, C; Colson, P; Da Costa, H; Facompré, M; Houssier, C; Joseph, B; Mérour, JY; Routier, S1

Reviews

5 review(s) available for pyrroles and Leukemia

ArticleYear
From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs).
    Angewandte Chemie (International ed. in English), 2017, 01-09, Volume: 56, Issue:2

    Topics: Anthramycin; Antibiotics, Antineoplastic; Antibodies; Benzodiazepines; Cell Proliferation; Female; Humans; Leukemia; Molecular Structure; Ovarian Neoplasms; Pyrroles

2017
Antiproliferative and proapoptotic effects of proteasome inhibitors and their combination with histone deacetylase inhibitors on leukemia cells.
    Cardiovascular & hematological disorders drug targets, 2009, Volume: 9, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Lactones; Leukemia; Oligopeptides; Protease Inhibitors; Pyrazines; Pyrroles

2009
Clinical experience with antiangiogenic therapy in leukemia.
    Current cancer drug targets, 2011, Volume: 11, Issue:9

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Benzenesulfonates; Bevacizumab; Clinical Trials as Topic; Humans; Indoles; Lenalidomide; Leukemia; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; Pyridines; Pyrroles; Quinazolines; Sorafenib; Staurosporine; Sunitinib; Thalidomide; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A

2011
Obatoclax mesylate : pharmacology and potential for therapy of hematological neoplasms.
    Expert opinion on investigational drugs, 2012, Volume: 21, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Clinical Trials as Topic; Drug Delivery Systems; Drug Resistance, Neoplasm; Humans; Indoles; Leukemia; Lymphoma; Proto-Oncogene Proteins c-bcl-2; Pyrroles

2012
[Possibility of targeting FLT3 kinase for the treatment of leukemia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2005, Volume: 46, Issue:3

    Topics: Animals; Antibodies, Monoclonal; Benzoquinones; Carbazoles; Drug Design; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Lactams, Macrocyclic; Leukemia; Mutation; Piperazines; Pyrroles; Quinazolines; Quinones; Rifabutin; Staurosporine; Sunitinib

2005

Trials

1 trial(s) available for pyrroles and Leukemia

ArticleYear
A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Dec-15, Volume: 14, Issue:24

    Topics: Adult; Aged; Aged, 80 and over; Electrocardiography; Female; Humans; Indoles; Leukemia; Male; Middle Aged; Proto-Oncogene Proteins c-bcl-2; Pyrroles

2008

Other Studies

30 other study(ies) available for pyrroles and Leukemia

ArticleYear
4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads.
    Journal of medicinal chemistry, 2021, 10-14, Volume: 64, Issue:19

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Drug Screening Assays, Antitumor; Histone Deacetylases; Humans; Leukemia; Nuclear Proteins; Pyrroles; Transcription Factors

2021
Major clinical response in a patient with leukemia cutis treated with the bromodomain inhibitor PLX51107 and azacitidine.
    Leukemia research, 2022, Volume: 119

    Topics: Azacitidine; Humans; Leukemia; Leukemia, Myeloid, Acute; Oxazoles; Pyridines; Pyrroles; Skin Neoplasms

2022
An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1.
    British journal of cancer, 2013, May-14, Volume: 108, Issue:9

    Topics: Acenaphthenes; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; BH3 Interacting Domain Death Agonist Protein; Cell Line, Tumor; Hematologic Neoplasms; Humans; Lethal Dose 50; Leukemia; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Pyrroles

2013
Involvement of oncogenic protein β-catenin in LPS-induced cytotoxicity in mouse mononuclear leukemia RAW 264.7 cells.
    Oncology research, 2013, Volume: 21, Issue:1

    Topics: Animals; beta Catenin; Cell Line; Cell Line, Tumor; Chalcones; Drug Interactions; Endoplasmic Reticulum Stress; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Leukemia; Lipopolysaccharides; Mice; Monocytes; Phosphorylation; Pyrimidines; Pyrroles; RNA, Small Interfering; Toll-Like Receptor 4; Transfection

2013
Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor salinosporamide A (Marizomib).
    Molecular pharmacology, 2014, Volume: 86, Issue:1

    Topics: Actinobacteria; Boronic Acids; Bortezomib; Catalysis; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Lactones; Leukemia; Mutation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Up-Regulation

2014
GDC-0152 induces apoptosis through down-regulation of IAPs in human leukemia cells and inhibition of PI3K/Akt signaling pathway.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015, Volume: 36, Issue:2

    Topics: Apoptosis; Baculoviral IAP Repeat-Containing 3 Protein; Caspase 9; Cell Proliferation; Cyclohexanes; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Inhibitor of Apoptosis Proteins; Leukemia; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrroles; Signal Transduction; Ubiquitin-Protein Ligases; X-Linked Inhibitor of Apoptosis Protein

2015
Comparison of in vitro antileukemic activity of obatoclax and ABT-737.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:8

    Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Survival; Flow Cytometry; Humans; Indoles; Leukemia; Nitrophenols; Piperazines; Pyrroles; Sulfonamides

2016
Regulation of leukemic cell differentiation and retinoid-induced gene expression by statins.
    Molecular cancer therapeutics, 2009, Volume: 8, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Atorvastatin; Cell Differentiation; Drug Synergism; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Gene Regulatory Networks; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia; Oligonucleotide Array Sequence Analysis; Pyrroles; Retinoids; Time Factors; Tretinoin; Tumor Cells, Cultured

2009
Synthesis and evaluation of the antiproliferative activity of novel pyrrolo[1,2-a]quinoxaline derivatives, potential inhibitors of Akt kinase. Part II.
    Journal of enzyme inhibition and medicinal chemistry, 2010, Volume: 25, Issue:2

    Topics: Benzimidazoles; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Design; Esters; Female; Humans; Leukemia; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrroles; Quinoxalines

2010
The combination of a histone deacetylase inhibitor with the Bcl-2 homology domain-3 mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, Aug-01, Volume: 16, Issue:15

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Benzamides; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Hydroxamic Acids; Indoles; Leukemia; Microscopy, Electron, Transmission; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; Vorinostat

2010
Two new amide alkaloids with anti-leukaemia activities from Aconitum taipeicum.
    Fitoterapia, 2010, Volume: 81, Issue:8

    Topics: Aconitum; Alkaloids; Animals; Antineoplastic Agents, Phytogenic; HL-60 Cells; Humans; Leukemia; Molecular Structure; Plant Roots; Pyrimidinones; Pyrroles

2010
Synthesis and in vitro evaluation of 3h-pyrrolo[3,2-f]-quinolin-9-one derivatives that show potent and selective anti-leukemic activity.
    ChemMedChem, 2010, Aug-02, Volume: 5, Issue:8

    Topics: Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Tumor; Drug Screening Assays, Antitumor; G2 Phase; Humans; Leukemia; Pyrroles; Quinolines; Reactive Oxygen Species; Structure-Activity Relationship; Tubulin; Tubulin Modulators

2010
Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs.
    Chemico-biological interactions, 2011, Oct-15, Volume: 194, Issue:1

    Topics: Apoptosis; Caspase 8; Humans; Lactones; Leukemia; Oxidative Stress; Protease Inhibitors; Pyrroles; Reactive Oxygen Species; Tumor Cells, Cultured

2011
Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation.
    The Journal of biological chemistry, 2012, Mar-23, Volume: 287, Issue:13

    Topics: Animals; bcl-X Protein; Biphenyl Compounds; Drug Resistance, Neoplasm; HL-60 Cells; Humans; Jurkat Cells; K562 Cells; Leukemia; Mice; Myeloid Cell Leukemia Sequence 1 Protein; Nitrophenols; Piperazines; Proteasome Endopeptidase Complex; Proteolysis; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides

2012
Investigations regarding the utility of prodigiosenes to treat leukemia.
    Organic & biomolecular chemistry, 2013, Jan-07, Volume: 11, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Leukemia; Molecular Structure; Neoplasms, Experimental; Prodigiosin; Pyrroles; Structure-Activity Relationship; Zebrafish

2013
Atorvastatin decreases Toll-like receptor 4 expression and downstream signaling in human monocytic leukemia cells.
    Cellular immunology, 2012, Volume: 279, Issue:1

    Topics: Atorvastatin; Blotting, Western; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression Regulation, Leukemic; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1beta; Interleukin-6; Leukemia; Lipopolysaccharides; Monocytes; NF-kappa B; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2012
Dual-specific Src and Abl kinase inhibitors, PP1 and CGP76030, inhibit growth and survival of cells expressing imatinib mesylate-resistant Bcr-Abl kinases.
    Blood, 2003, Jan-15, Volume: 101, Issue:2

    Topics: Apoptosis; Benzamides; Binding Sites; Cell Division; Cell Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Imatinib Mesylate; Leukemia; Models, Molecular; Mutagenesis, Site-Directed; Oncogene Proteins v-abl; Piperazines; Protein Conformation; Pyrazoles; Pyrimidines; Pyrroles; src-Family Kinases

2003
SOME 2-SUBSTITUTED AMINOPURINES AND PURINE ANALOGS.
    Journal of medicinal chemistry, 1963, Volume: 6

    Topics: 2-Aminopurine; Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Leukemia; Leukemia, Experimental; Morpholines; Pharmacology; Piperidines; Purines; Pyrimidines; Pyrroles; Research; Sarcoma 180

1963
Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation o
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 310, Issue:3

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Carbazoles; Dactinomycin; Drug Resistance, Neoplasm; Etoposide; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; K562 Cells; Leukemia; Leukocytes, Mononuclear; Mitogen-Activated Protein Kinases; Oxazepines; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Subcellular Fractions; Tumor Cells, Cultured; Ultraviolet Rays

2004
Synergistic effect of SU11248 with cytarabine or daunorubicin on FLT3 ITD-positive leukemic cells.
    Blood, 2004, Dec-15, Volume: 104, Issue:13

    Topics: Antineoplastic Agents; Cell Division; Cell Line; Cell Line, Tumor; Cytarabine; Daunorubicin; Drug Synergism; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Leukemia; Pyrroles; Sunitinib; Zinc Fingers

2004
Evaluation of apoptosis and necrosis induced by statins using fluorescence-enhanced flow cytometry.
    Journal of pharmaceutical and biomedical analysis, 2005, Sep-15, Volume: 39, Issue:3-4

    Topics: Apoptosis; Atorvastatin; Avidin; Biotin; Cell Line; Cell Separation; Cells, Cultured; Drug Industry; Drug Screening Assays, Antitumor; Fatty Acids, Monounsaturated; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Leukemia; Microscopy, Fluorescence; Necrosis; Pharmaceutical Preparations; Pravastatin; Propidium; Pyridines; Pyrroles; Simvastatin; Time Factors

2005
The antitumor effects of sunitinib (formerly SU11248) against a variety of human hematologic malignancies: enhancement of growth inhibition via inhibition of mammalian target of rapamycin signaling.
    Molecular cancer therapeutics, 2006, Volume: 5, Issue:10

    Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Everolimus; Hematologic Neoplasms; Humans; Indoles; Leukemia; Mutation; Phosphoproteins; Protein Kinases; Pyrroles; Receptor Protein-Tyrosine Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Sunitinib; TOR Serine-Threonine Kinases

2006
NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells.
    Blood, 2007, Jul-01, Volume: 110, Issue:1

    Topics: Animals; Apoptosis; Caspase 8; Cell Line, Tumor; Histone Deacetylase Inhibitors; Humans; Lactones; Leukemia; Mice; Oxidative Stress; Protease Inhibitors; Proteasome Inhibitors; Pyrroles; Reactive Oxygen Species; Tumor Burden; Tumor Cells, Cultured

2007
Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene.
    Leukemia research, 2008, Volume: 32, Issue:6

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzimidazoles; Cell Proliferation; Female; fms-Like Tyrosine Kinase 3; Humans; Indoles; Leukemia; Leukemia, Megakaryoblastic, Acute; Leukemia, Myeloid, Acute; Male; MAP Kinase Kinase 1; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Pyrroles; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sunitinib; Tumor Cells, Cultured

2008
Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).
    Cancer research, 2008, May-01, Volume: 68, Issue:9

    Topics: Animals; Antineoplastic Agents; Apoptosis; AraC Transcription Factor; Biomimetics; Biphenyl Compounds; Cells, Cultured; Drug Synergism; HL-60 Cells; Humans; Indoles; Leukemia; Mice; Mice, Knockout; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Nitrophenols; Piperazines; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Tumor Stem Cell Assay; U937 Cells

2008
TGF-beta receptor kinase inhibitor LY2109761 reverses the anti-apoptotic effects of TGF-beta1 in myelo-monocytic leukaemic cells co-cultured with stromal cells.
    British journal of haematology, 2008, Volume: 142, Issue:2

    Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cells, Cultured; Coculture Techniques; Enzyme Inhibitors; Humans; Leukemia; Lipopolysaccharide Receptors; Mesenchymal Stem Cells; Pyrazoles; Pyrroles; Receptors, Transforming Growth Factor beta; Stromal Cells; Transforming Growth Factor beta1; U937 Cells

2008
[Origin and pathogenesis of polymeric dipyrrilmethenes].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1980, Jul-15, Volume: 35, Issue:14

    Topics: Anemia, Megaloblastic; Benzopyrans; Bile; Cholestasis; Common Bile Duct; Duodenum; Hemolysis; Humans; Leukemia; Liver Diseases; Pyrroles

1980
Structure-activity studies of benzimidazole-based DNA-cleaving agents. Comparison of benzimidazole, pyrrolobenzimidazole, and tetrahydropyridobenzimidazole analogues.
    Journal of medicinal chemistry, 1994, Jan-07, Volume: 37, Issue:1

    Topics: Alkylation; Antineoplastic Agents; Base Sequence; Benzimidazoles; DNA; Leukemia; Magnetic Resonance Spectroscopy; Melanoma; Molecular Sequence Data; Molecular Structure; Molecular Weight; Pyridines; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured

1994
2-Diazopyrroles: synthesis and antileukemic activity.
    Farmaco (Societa chimica italiana : 1989), 1996, Volume: 51, Issue:4

    Topics: Animals; Antineoplastic Agents; Humans; Leukemia; Mice; Pyrroles; Tumor Cells, Cultured

1996
Synthesis, cytotoxicity, DNA interaction and topoisomerase II inhibition properties of tetrahydropyrrolo[3,4-a]carbazole-1,3-dione and tetrahydropyrido-[3,2-b]pyrrolo[3,4-g]indole-1,3-dione derivatives.
    Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:6

    Topics: Animals; Biochemistry; Cell Cycle; Circular Dichroism; DNA; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Indoles; Leukemia; Mice; Molecular Structure; Pyrroles; Topoisomerase II Inhibitors; Toxicity Tests; Tumor Cells, Cultured

2001