pyrroles has been researched along with Leukemia, Myeloid in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 14 (70.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Breen, M; Culver, S; Dunbar, M; Kow, K; Milner, RJ; Owen, JL; Pérez, ML | 1 |
| Chang, CN; Chen, CH; Chen, GS; Chen, YC; Chern, JW; Chou, NT; Chou, SH; Hseu, TH; Hsu, HC; Hu, TL; Huang, CH; Hwang, CS; Khanwelkar, RR; Ko, CH; Lee, O; Lin, HC; Lin, MW; Liu, CP; Shih, YC; Tsai, YJ; Tseng, HW; Tu, CM; Wang, HC; Wang, LM; Yu, CW | 1 |
| Chu, DT | 1 |
| Attkisson, E; Aust, MM; Ferreira-Gonzalez, A; Grant, S; Rahmani, M; Williams, DC | 1 |
| Giles, FJ | 1 |
| Abrams, TJ; Cherrington, JM; Heinrich, MC; Hong, W; Lee, LB; Louie, SG; Manning, WC; Murray, LJ; Ngai, TJ; O'Farrell, AM; Smolich, BD; Town, A; Wong, LM; Yee, KW; Yuen, HA | 1 |
| Albitar, M; Cherrington, JM; Cooper, MA; Cortes, JE; Giles, FJ; Hannah, AL; Hong, W; Kantarjian, HM; Karp, JE; Lancet, JE; Louie, SG; O'Brien, SM; O'Farrell, AM; Silverman, LR; Stopeck, AT; Verstovsek, S; Yuen, HA | 1 |
| Albitar, M; Cherrington, JM; Giles, FJ; Hannah, AL; Hong, W; Karp, JE; Lancet, JE; Louie, SG; O'Farrell, AM; Silverman, LR; Smolich, B; Stopeck, AT; Yuen, HA | 1 |
| Advani, AS | 1 |
| Böhmer, FD; Cénac, C; Dove, S; Eichhorn, E; Elz, S; Fischer, T; Heidel, F; Höcher, H; Hufsky, H; Mahboobi, S; Pongratz, H; Sellmer, A; Sicker, M; Stocking, C; Trümpler, A; Uecker, A | 1 |
| Bainbridge, T; Braziel, RM; Cherrington, JM; Griffith, DJ; Haley, AD; Heinrich, MC; McGreevey, L; O'Farrell, AM; Schittenhelm, MM; Town, A; Tyner, JW; Yee, KW | 1 |
| Hiramatsu, A; Imai, N; Imamura, A; Itoh, M; Mihara, H; Miwa, H; Nitta, M; Satoh, A; Shikami, M; Suganuma, K; Watarai, M | 1 |
| Buhaescu, I; Deray, G; Izzedine, H; Rixe, O | 1 |
| Campiani, G; Greene, LM; Kelly, L; Lawler, M; Onnis, V; Williams, DC; Zisterer, DM | 1 |
| Blaser, BW; Briesewitz, R; Caligiuri, MA; Duchemin, AM; Kusewitt, DF; Liu, T; Wang, J; Wang, L | 1 |
| Hida, T; Ikeda, Y; Kizaki, M; Koeffler, HP; Matsushita, H; Muto, A; Nishihara, T; Ueno, H; Yamato, K; Yoshimura, H | 1 |
| Albitar, M; Cherrington, JM; Giles, FJ; Smolich, BD; West, KA; Yuen, HA | 1 |
| Berdel, WE; Bieker, R; Büchner, T; Fiedler, W; Göner, M; Kelsey, S; Kreuter, M; Mesters, RM; Padró, T; Scigalla, P; Steins, M | 1 |
| Dimitroulakos, J; Minden, MD; Penn, LZ; Tan, MM; Wong, WW; Xia, Z | 1 |
| Lalezari, I; Schwartz, EL | 1 |
3 review(s) available for pyrroles and Leukemia, Myeloid
| Article | Year |
|---|---|
[Clinical manifestation of targeted drugs in individualized therapy of malignant tumors].
Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cyclophosphamide; Doxorubicin; Drug Delivery Systems; ErbB Receptors; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid; Lymphoma, Large B-Cell, Diffuse; Mutation; Neoplasms; Piperazines; Prednisone; Pyrimidines; Pyrroles; Remission Induction; Rituximab; Sunitinib; Vincristine | 2010 |
New drugs in acute myeloid leukemia.
Topics: Acute Disease; Adenine Nucleotides; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents; Arabinonucleosides; Azacitidine; Bevacizumab; Boronic Acids; Bortezomib; Clofarabine; Cytosine; Decitabine; Dioxolanes; Humans; Indoles; Leukemia, Myeloid; Phthalazines; Pyrazines; Pyridines; Pyrroles; Thionucleotides | 2002 |
C-kit as a target in the treatment of acute myelogenous leukemia.
Topics: Acute Disease; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Clinical Trials as Topic; Hematopoiesis; Humans; Imatinib Mesylate; Indoles; Leukemia, Myeloid; Mice; Oxindoles; Piperazines; Propionates; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Stem Cell Factor | 2005 |
2 trial(s) available for pyrroles and Leukemia, Myeloid
| Article | Year |
|---|---|
SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes.
Topics: Acute Disease; Adult; Aged; Antineoplastic Agents; Apoptosis; Bone Marrow Cells; Bone Marrow Examination; Humans; Indoles; Leukemia, Myeloid; Middle Aged; Myelodysplastic Syndromes; Necrosis; Pharmacokinetics; Protein-Tyrosine Kinases; Pyrroles; Remission Induction; Salvage Therapy | 2003 |
Effects of SU5416, a small molecule tyrosine kinase receptor inhibitor, on FLT3 expression and phosphorylation in patients with refractory acute myeloid leukemia.
Topics: Acute Disease; Adult; Aged; Bone Marrow; Down-Regulation; Female; fms-Like Tyrosine Kinase 3; Humans; Indoles; Leukemia, Myeloid; Male; Membrane Proteins; Middle Aged; Mutation; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrroles; Receptor Protein-Tyrosine Kinases; Stem Cell Factor | 2004 |
15 other study(ies) available for pyrroles and Leukemia, Myeloid
| Article | Year |
|---|---|
Partial cytogenetic response with toceranib and prednisone treatment in a young dog with chronic monocytic leukemia.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Dog Diseases; Dogs; Female; Fusion Proteins, bcr-abl; In Situ Hybridization, Fluorescence; Indoles; Leukemia, Myeloid; Prednisone; Pyrroles; Translocation, Genetic; Treatment Outcome | 2013 |
Synthesis and structure-activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors.
Topics: Animals; Aurora Kinases; Binding Sites; Cell Line, Tumor; Computer Simulation; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Indoles; Leukemia, Myeloid; Mice; Oxindoles; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrroles; Receptors, Platelet-Derived Growth Factor; Structure-Activity Relationship; Transplantation, Heterologous; Urea | 2010 |
Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Benzenesulfonates; Cells, Cultured; Drug Synergism; Female; HL-60 Cells; Humans; Indoles; Leukemia, Myeloid; Membrane Proteins; Mice; Mice, Nude; Niacinamide; Phenylurea Compounds; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyridines; Pyrroles; Sorafenib; U937 Cells; Up-Regulation; Xenograft Model Antitumor Assays | 2012 |
SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo.
Topics: Acute Disease; Amino Acid Substitution; Animals; Antineoplastic Agents; Apoptosis; Bone Marrow Transplantation; Endothelial Growth Factors; Enzyme Inhibitors; Female; fms-Like Tyrosine Kinase 3; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Leukemia, Myeloid; Lymphokines; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Neoplasm Proteins; Phosphorylation; Point Mutation; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proto-Oncogene Proteins; Pyrroles; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Signal Transduction; Sunitinib; Tandem Repeat Sequences; Transfection; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xenograft Model Antitumor Assays | 2003 |
Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase.
Topics: Acute Disease; Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Cell Line; Cell Line, Tumor; fms-Like Tyrosine Kinase 3; Humans; In Vitro Techniques; Indoles; Leukemia, Myeloid; Ligands; Mice; Models, Molecular; Phosphorylation; Pyrroles; Receptors, Platelet-Derived Growth Factor; Structure-Activity Relationship | 2006 |
FLT3 K663Q is a novel AML-associated oncogenic kinase: Determination of biochemical properties and sensitivity to Sunitinib (SU11248).
Topics: Acute Disease; Amino Acid Sequence; Amino Acid Substitution; Animals; Antineoplastic Agents; Apoptosis; Base Sequence; Cell Division; Cell Line, Tumor; fms-Like Tyrosine Kinase 3; Humans; Indoles; Leukemia, Myeloid; Mice; Mice, Inbred BALB C; Mice, Nude; Mutagenesis, Site-Directed; Neoplasm Transplantation; Point Mutation; Pyrroles; Sunitinib | 2006 |
t(8;21) acute myeloid leukaemia cells are dependent on vascular endothelial growth factor (VEGF)/VEGF receptor type2 pathway and phosphorylation of Akt.
Topics: Acute Disease; Adult; Aged; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromosomes, Human, Pair 15; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 21; Chromosomes, Human, Pair 8; Female; Humans; Indoles; Leukemia, Myeloid; Male; Middle Aged; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrroles; Translocation, Genetic; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2006 |
Sunitinib malate.
Topics: Antineoplastic Agents; Carcinoma, Small Cell; Cell Division; Cell Line, Tumor; Disease Progression; Endothelium, Vascular; Enzyme Inhibitors; Gastrointestinal Stromal Tumors; Humans; Indoles; Leukemia, Myeloid; Lung Neoplasms; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Sunitinib | 2007 |
STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells.
Topics: Apoptosis; bcl-X Protein; Benzamides; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Survival; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Fusion Proteins, bcr-abl; HL-60 Cells; Humans; Imatinib Mesylate; K562 Cells; Leukemia, Myeloid; Microtubules; Monocytes; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Oxazepines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Pyrroles | 2007 |
Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia.
Topics: Acute Disease; Animals; Blotting, Western; Bone Marrow Cells; Cell Proliferation; Cyclin D2; Cyclin D3; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; fms-Like Tyrosine Kinase 3; G1 Phase; Humans; Immunoprecipitation; Indoles; Intracellular Signaling Peptides and Proteins; Leukemia, Myeloid; Mice; Mice, SCID; Morpholines; Mutation; Phosphorylation; Piperazines; Pyridines; Pyrroles; Retinoblastoma Protein; Signal Transduction; Tumor Cells, Cultured | 2007 |
A novel retinoic acid receptor (RAR)-selective antagonist inhibits differentiation and apoptosis of HL-60 cells: implications of RARalpha-mediated signals in myeloid leukemic cells.
Topics: Alitretinoin; Anthracenes; Apoptosis; Cell Differentiation; Cell Division; Drug Resistance; HL-60 Cells; Humans; Leukemia, Myeloid; Leukocytes; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Signal Transduction; Tretinoin | 1998 |
The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts.
Topics: Angiogenesis Inhibitors; Apoptosis; Caspase 3; Caspases; Cell Division; Dose-Response Relationship, Drug; Humans; Indoles; Leukemia, Myeloid; Mitogen-Activated Protein Kinases; Oxindoles; Phosphorylation; Propionates; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Pyrroles; Stem Cell Factor; Tumor Cells, Cultured | 2001 |
Stable remission after administration of the receptor tyrosine kinase inhibitor SU5416 in a patient with refractory acute myeloid leukemia.
Topics: Acute Disease; Angiogenesis Inhibitors; Antineoplastic Agents; Bone Marrow Cells; Endothelium, Vascular; Female; Humans; Immunohistochemistry; Indoles; Leukemia, Myeloid; Middle Aged; Protein-Tyrosine Kinases; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Remission Induction | 2001 |
Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin.
Topics: Acute Disease; Apoptosis; Atorvastatin; Cell Division; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Leukemia, Myeloid; Lovastatin; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyridines; Pyrroles; Sensitivity and Specificity; Tumor Cells, Cultured | 2001 |
Synthesis and antineoplastic activity of 5-aryl-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-dimethanol 6,7-bis(isopropylcarbamates).
Topics: Carbamates; Cell Division; Cell Survival; Chemical Phenomena; Chemistry; Colonic Neoplasms; Humans; Leukemia, Myeloid; Neoplasms; Pyrroles; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured | 1988 |