pyrroles has been researched along with Leukemia, Myelogenous, Chronic, BCR-ABL Positive in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.45) | 18.2507 |
| 2000's | 15 (51.72) | 29.6817 |
| 2010's | 10 (34.48) | 24.3611 |
| 2020's | 3 (10.34) | 2.80 |
| Authors | Studies |
|---|---|
| Andrade, CAS; Avelino, KYPS; Lucena-Silva, N; Oliveira, LS; Oliveira, MDL; Santos, MR | 1 |
| Abe, A; Hayakawa, F; Ichihara, M; Inoue, C; Kawamoto, Y; Murate, T; Nishizawa, Y; Nozawa, Y; Sobue, S; Suzuki, M | 1 |
| Cao, X; Huang, H; Lei, X; Liu, J; Peng, J; Tang, G; Zhang, Y | 1 |
| Sendo, T; Shimada, A; Yagi, K | 1 |
| Almeida, VH; Berzoti-Coelho, MG; Borges, CS; Cacemiro, MDC; Castro, FA; Ferreira, AF; Figueiredo-Pontes, LL; Gomes, FG; Monteiro, RQ; Nunes, NS; Simões, BP | 1 |
| Burley, GA; Fang, L; Gómez-Castañeda, E; Hayatigolkhatmi, K; Hsieh, YC; Jackson, L; Jørgensen, HG; Padroni, G; Pellicano, F; Su, W | 1 |
| Czarnecka, AM; Oborska, S; Rzepecki, P; Szczylik, C | 1 |
| Bagan, P; Bilan, P; Couffinhal, JC; Dakhil, B; Fargeas, C; Mahé, E; Roger, A; Sigal, ML; Sin, C | 1 |
| Balabanov, S; Bokemeyer, C; Brümmendorf, TH; Fiedler, W; Gontarewicz, A; Keller, G; Moll, J; Panse, J; Schafhausen, P | 1 |
| Donato, NJ; Pene-Dumitrescu, T; Peterson, LF; Smithgall, TE | 1 |
| Di Stefano, C; Marfe, G | 1 |
| Bright, SA; Campiani, G; Deininger, MW; Lawler, M; Williams, DC; Zisterer, DM | 1 |
| Bright, SA; Campiani, G; Carroll, P; Conneally, E; Deininger, MW; Lawler, M; McElligott, AM; O'Connell, JW; O'Connor, L; Williams, DC; Zisterer, DM | 1 |
| Addya, S; Audia, A; Calabretta, B; Cattelani, S; Ferrari-Amorotti, G; Fragliasso, V; Holyoake, TL; Lidonnici, MR; Manzotti, G; Mariani, SA; Perini, G; Peterson, L; Soliera, AR | 1 |
| Airley, R | 1 |
| Choi, HJ; Kamens, J; Schreiner, SJ; Smithgall, TE; Wilson, MB | 1 |
| Buchdunger, E; Fabbro, D; Hallek, M; Hu, Y; Li, S; Liu, Y; Pelletier, S; Van Etten, RA; Warmuth, M | 1 |
| Galski, H; Lazarovici, P; Nagler, A; Sivan, H | 1 |
| Mahadevan, D | 1 |
| Campiani, G; Mc Gee, MM; McGrath, LB; Onnis, V; Williams, DC; Zisterer, DM | 1 |
| Abruzzese, E; Amadori, S; Artico, M; Catalano, G; Cirilli, R; Ciriolo, MR; Di Stefano, C; Filomeni, G; La Regina, G; La Torre, F; Lavecchia, A; Marfè, G; Morgante, E; Morgante, M; Novellino, E; Russo, MA; Silvestri, R; Sinibaldi Salimei, P | 1 |
| Nishida, T | 1 |
| Berets, O; Bladé, JS; Defuentes, G | 1 |
| Kimura, S; Maekawa, T; Morinaga, K; Ueda, T; Yamauchi, T | 1 |
| Alvarez, D; Chou, CJ; Dervan, PB; Farkas, ME; Gottesfeld, JM; Tsai, SM | 1 |
| Hartley, JA; Haskell, MK; Lee, M; McAdam, SR; Roldan, MC | 1 |
| Campiani, G; Fattorusso, C; Lawler, M; Mc Gee, MM; Nacci, V; Ramunno, A; Williams, DC; Zisterer, DM | 1 |
| Allen, SL; Bentley, M; Brody, JP; Carnicero, F; Cross, NC; Demiroglu, A; Doody, ML; Goldman, JM; Hawson, G; Heath, C; Koduru, P; Melo, JV; Reiter, A; Rodwell, R; Steer, EJ; Taylor, K | 1 |
| Campiani, G; Lawler, M; Mc Gee, MM; Nacci, V; Ramunno, A; Williams, DC; Zisterer, DM | 1 |
2 review(s) available for pyrroles and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
Recent advances in Bcr-Abl tyrosine kinase inhibitors for overriding T315I mutation.
Topics: Binding Sites; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Docking Simulation; Polymorphism, Single Nucleotide; Protein Kinase Inhibitors; Proto-Oncogene Mas; Pyridines; Pyrroles | 2021 |
In vitro anti-leukaemia activity of pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs).
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Structure; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Thiazepines | 2010 |
27 other study(ies) available for pyrroles and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
Electrochemical DNA biosensor for chronic myelocytic leukemia based on hybrid nanostructure.
Topics: Biosensing Techniques; DNA; Electrochemical Techniques; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Nanocomposites; Polymers; Pyrroles; Reproducibility of Results | 2022 |
Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells.
Topics: Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cyclin D2; Drug Resistance, Neoplasm; Drug Synergism; Glycogen Synthase Kinase 3; Humans; Imatinib Mesylate; Imidazoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leupeptins; Macrocyclic Compounds; Myeloid Cell Leukemia Sequence 1 Protein; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Phosphatase 2; Proteolysis; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Pyridazines; Pyrroles; Signal Transduction; Wortmannin | 2020 |
Pharmacological inhibition of JAK3 enhances the antitumor activity of imatinib in human chronic myeloid leukemia.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Humans; Imatinib Mesylate; Janus Kinase 3; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplastic Stem Cells; Piperidines; Pyrimidines; Pyrroles; Signal Transduction | 2018 |
Crosstalk between BCR-ABL and protease-activated receptor 1 (PAR1) suggests a novel target in chronic myeloid leukemia.
Topics: Adult; Aged; Antineoplastic Agents; Apoptosis; Case-Control Studies; Cell Line, Tumor; Chromones; Disease Progression; Dose-Response Relationship, Drug; Female; Flavonoids; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Morpholines; Myeloid Cells; Philadelphia Chromosome; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinazolines; Receptor, PAR-1; Signal Transduction; Treatment Outcome; Vascular Endothelial Growth Factor A | 2018 |
An investigation of targeted inhibition of transcription factor activity with pyrrole imidazole polyamide (PA) in chronic myeloid leukemia (CML) blast crisis cells.
Topics: Antineoplastic Agents; Blast Crisis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; E2F1 Transcription Factor; Humans; Imidazoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Structure; Nylons; Protein Kinase Inhibitors; Pyrroles; Structure-Activity Relationship | 2019 |
Development of chronic myeloid leukaemia in patients treated with anti-VEGF therapies for clear cell renal cell cancer.
Topics: Adult; Aged; Bone Marrow Cells; Carcinoma, Renal Cell; Humans; Indoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Molecular Targeted Therapy; Niacinamide; Phenylurea Compounds; Pyrroles; Sorafenib; Sunitinib; Vascular Endothelial Growth Factor A | 2015 |
[Leg ulcers occurring under tyrosine kinase inhibitor therapy (sunitinib, nilotinib)].
Topics: Aged, 80 and over; Antineoplastic Agents; Bile Duct Neoplasms; Cholangiocarcinoma; Female; Humans; Indoles; Leg Ulcer; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Pyrimidines; Pyrroles; Sunitinib; Withholding Treatment; Wound Healing | 2017 |
PHA-680626 exhibits anti-proliferative and pro-apoptotic activity on Imatinib-resistant chronic myeloid leukemia cell lines and primary CD34+ cells by inhibition of both Bcr-Abl tyrosine kinase and Aurora kinases.
Topics: Antigens, CD; Antigens, CD34; Antineoplastic Agents; Apoptosis; Aurora Kinase B; Aurora Kinases; Benzamides; Cell Division; Cell Line, Tumor; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrroles | 2008 |
An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Fusion Proteins, bcr-abl; Humans; Insecta; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mutation; Proto-Oncogene Proteins c-hck; Pyrimidines; Pyrroles; src-Family Kinases | 2008 |
Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Flavonoids; Humans; Imatinib Mesylate; Inhibitor of Apoptosis Proteins; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Microtubule-Associated Proteins; Oxazepines; Piperazines; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Survivin | 2010 |
Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo.
Topics: Adult; Aged; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Separation; Cell Survival; Drug Resistance, Neoplasm; Female; Flow Cytometry; Genes, abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Mice, Inbred BALB C; Middle Aged; Mutation; Oxazepines; Pyrroles | 2010 |
Gfi-1 inhibits proliferation and colony formation of p210BCR/ABL-expressing cells via transcriptional repression of STAT 5 and Mcl-1.
Topics: Biomarkers, Tumor; Blotting, Western; Cell Proliferation; Chromatin Immunoprecipitation; Colony-Forming Units Assay; DNA-Binding Proteins; Down-Regulation; Gene Expression Profiling; Humans; Immunoenzyme Techniques; Indoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Luciferases; Myeloid Cell Leukemia Sequence 1 Protein; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; STAT5 Transcription Factor; Transcription Factors; Tumor Cells, Cultured | 2012 |
Lab reports and cat scans: can veterinary oncology guide our way to new treatments for human cancers?
Topics: Animals; Antineoplastic Agents; Benzamides; Breast Neoplasms; Cats; Disease Models, Animal; Dogs; Female; Humans; Imatinib Mesylate; Indoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mast-Cell Sarcoma; Neoplasms; Piperazines; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Thiazoles; Transcriptome | 2012 |
Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis.
Topics: Apoptosis; Cell Division; Cell Transformation, Neoplastic; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; K562 Cells; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Milk Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monocytes; Neoplasm Proteins; Phosphorylation; Protein Processing, Post-Translational; Pyrimidines; Pyrroles; Signal Transduction; src-Family Kinases; STAT5 Transcription Factor; Trans-Activators; Tumor Cells, Cultured | 2002 |
Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia.
Topics: Animals; Benzamides; Burkitt Lymphoma; Cell Division; Drug Therapy, Combination; Enzyme Activation; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Piperazines; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-hck; Pyrimidines; Pyrroles; src-Family Kinases | 2004 |
In vitro and in vivo reversal of MDR1-mediated multidrug resistance by KT-5720: implications on hematological malignancies.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blast Crisis; Carbazoles; Cell Line, Tumor; Daunorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Indoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Inbred BALB C; Mice, Transgenic; Multiple Myeloma; Pyrroles | 2006 |
Will MDR-1/P-gp modulators provide clinical benefit in hematologic malignancies?
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blast Crisis; Carbazoles; Cell Line, Tumor; Daunorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Indoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Inbred BALB C; Mice, Transgenic; Multiple Myeloma; Pyrroles | 2006 |
Caspase-activated DNase (CAD)-independent oligonucleosomal DNA fragmentation in chronic myeloid leukaemia cells; a requirement for serine protease and Mn2+-dependent acidic endonuclease activity.
Topics: Apoptosis; Caspase 3; Cell Extracts; Cytoplasm; Deoxyribonucleases; DNA Fragmentation; Endonucleases; Humans; Hydrogen-Ion Concentration; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Manganese; Mitochondria; Oxazepines; Peptide Hydrolases; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Serine Endopeptidases | 2006 |
Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A new class of agents with high apoptotic activity in chronic myelogenous leukemia K562 cells and in cells from patients at onset and who were imatinib-resistant.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Bone Marrow Cells; Caspase 3; Caspase 8; Caspase 9; Caspases; Drug Resistance, Neoplasm; Enzyme Activation; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Thiazepines; Tumor Cells, Cultured | 2006 |
[Imatinib . Sunitinib].
Topics: Angiogenesis Inhibitors; Benzamides; Carcinoma, Renal Cell; Dermatofibrosarcoma; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Kidney Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Skin Neoplasms; Sunitinib; Survival Rate | 2007 |
Tyrosine kinase inhibitors for chronic myelogenous leukemia.
Topics: Benzamides; Fusion Proteins, bcr-abl; Humans; Hypothyroidism; Imatinib Mesylate; Indoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Sunitinib | 2007 |
Overcoming imatinib resistance using Src inhibitor CGP76030, Abl inhibitor nilotinib and Abl/Lyn inhibitor INNO-406 in newly established K562 variants with BCR-ABL gene amplification.
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzamides; Blotting, Western; Cell Proliferation; Drug Resistance, Neoplasm; Flow Cytometry; Fusion Proteins, bcr-abl; Gene Amplification; Genes, abl; Humans; Imatinib Mesylate; In Situ Hybridization, Fluorescence; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mutation; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; src-Family Kinases | 2008 |
Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia.
Topics: Alkylation; Animals; Base Sequence; Blotting, Western; Cell Cycle; Cell Proliferation; Cell Survival; Chlorambucil; Female; Histones; Humans; Imidazoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Nude; Molecular Sequence Data; Nylons; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2008 |
In vitro photoinduced cytotoxicity and DNA binding properties of psoralen and coumarin conjugates of netropsin analogues: DNA sequence-directed alkylation and cross-link formation.
Topics: Alkylation; Antineoplastic Agents; Base Composition; Coumarins; Cross-Linking Reagents; DNA; Ficusin; Furocoumarins; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Light; Molecular Structure; Netropsin; Photochemistry; Photochemotherapy; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 3; Caspases; Down-Regulation; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Oncogene Proteins, Fusion; Oxazepines; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein-Tyrosine Kinases; Pyrroles; Reactive Oxygen Species; Tumor Cells, Cultured | 2001 |
The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins.
Topics: Aged; Amino Acid Sequence; Base Sequence; Cell Division; Chromosomes, Human, Pair 22; Chromosomes, Human, Pair 8; Enzyme Inhibitors; Female; Fusion Proteins, bcr-abl; Humans; In Situ Hybridization, Fluorescence; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Middle Aged; Molecular Sequence Data; Oncogene Proteins; Oncogene Proteins, Fusion; Phosphoinositide-3 Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcr; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transfection; Translocation, Genetic | 2001 |
Activation of the c-Jun N-terminal kinase (JNK) signaling pathway is essential during PBOX-6-induced apoptosis in chronic myelogenous leukemia (CML) cells.
Topics: Activating Transcription Factor 2; Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Carrier Proteins; Cyclic AMP Response Element-Binding Protein; Dicumarol; Enzyme Activation; Enzyme Inhibitors; Humans; JNK Mitogen-Activated Protein Kinases; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mitogen-Activated Protein Kinases; Oxazepines; Phosphorylation; Proto-Oncogene Proteins c-jun; Pyrroles; Signal Transduction; Substrate Specificity; Transcription Factors | 2002 |