pyrroles has been researched along with Invasiveness, Neoplasm in 97 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 28 (28.87) | 29.6817 |
| 2010's | 62 (63.92) | 24.3611 |
| 2020's | 7 (7.22) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, XY; Xu, J; Zhang, H; Zhang, P | 1 |
| Chen, CY; Lan, SJ; Lan, YH; Lin, YJ; Sheu, MJ; Wang, CCN | 1 |
| Lang, L; Shay, C; Teng, Y; Wang, X; Xiong, Y; Zhao, X | 1 |
| Alchami, F; Bale, C; Bezecny, P; Butler, R; Carucci, M; Casbard, A; Cox, C; Foxley, A; Howell, SJ; Joffe, J; Jones, RH; Madden, TA; Moon, S; Twelves, C; Venkitaraman, R; Waters, S | 1 |
| Ren, H; Wang, J; Xue, R; Zhou, Y | 1 |
| Abe, H; Fujiwara, K; Fukuda, N; Midorikawa, Y; Miki, T; Nagase, H; Soma, M; Takagi, K; Takayama, T | 1 |
| Al-Gayyar, MMH; Alattar, A; Alshaman, R; El-Kannishy, SMH; Hamdan, AM; Hassan, HM | 1 |
| Chow, Z; Evers, BM; Johnson, J; Lee, E; Rychahou, P; Weiss, HL | 1 |
| Apostolidi, M; Gassaway, BM; Gaule, P; Muthusamy, V; Rimm, DL; Rinehart, J; Vathiotis, IA | 1 |
| Chen, H; Li, H; Liu, C; Qian, B; Yao, Y; Zhang, J | 1 |
| Aerts, JG; Bezemer, K; Dammeijer, F; Hegmans, JP; Hendriks, RW; Kaijen-Lambers, ME; Lievense, LA; van Hall, T; van Nimwegen, M | 1 |
| Bao, L; Cao, Q; Chen, K; Chen, X; Gao, Y; Hu, W; Li, X; Liu, L; Qu, Y; Ru, Z; Ruan, H; Song, Z; Tong, J; Wang, K; Xiao, H; Xiao, W; Xiong, Z; Xu, G; Yang, H; Yuan, C; Zhang, X | 1 |
| Mikami, Y; Murofushi, T; Suzuki, N; Tsuda, H; Yamaguchi, Y | 1 |
| Bullova, P; Cougnoux, A; Kopacek, J; Marzouca, G; Pacak, K | 1 |
| Chen, X; Guo, J; Lin, Z; Liu, L; Qu, Y; Wang, J; Wang, Z; Xiong, Y; Xu, J; Yang, Y | 1 |
| Hirasaka, K; Nagano, H; Nikawa, T; Ohno, A; Teshima-Kondo, S; Tomida, C; Uchida, T; Yamagishi, N | 1 |
| Hou, XF; Li, K; Li, S; Wang, JF; Wu, C; Xu, SN | 1 |
| Aubé, J; Baserga, SJ; Bian, Y; Chen, W; Chow, E; Dextras, C; Fang, M; Farley, KI; Feldman, C; Ferrer, M; Frankowski, KJ; Goldberg, E; Griner, LM; Hu, D; Huang, H; Huang, S; Kandela, I; Kang, J; Khanolkar, O; Kim, HR; Knotts, Z; Kozlov, S; Lewandowska, MA; Li, D; Long, C; Marugan, JJ; Mazar, A; Meng, Z; Nagashima, K; Norton, J; Patnaik, S; Powers, AS; Quadri, HS; Rudloff, U; Sahagian, G; Schoenen, FJ; Shilatifard, A; Southall, N; Sultan, J; Sun, W; Teper, Y; Titus, S; Vilimas, T; Wang, C; Wen, Y; Xi, R; Zheng, W; Zhou, M | 1 |
| Li, B; Liang, H; Ou-Yang, Q; Xu, M | 1 |
| Ghosh, PM; Sam, A; Steele, TM; Talbott, GC; Tepper, CG; Vinall, RL | 1 |
| Barone, C; Basso, M; Biolato, M; Castaldi, P; De Gaetano, AM; Grieco, A; Iaculli, A; Leccisotti, L; Miele, L; Pompili, M; Riccardi, L; Rufini, V | 1 |
| Cassinelli, G; Cominetti, D; Favini, E; Lanzi, C; Penco, S; Petrangolini, G; Pisano, C; Tortoreto, M; Vlodavsky, I; Zaffaroni, N; Zunino, F | 1 |
| Aline-Fardin, A; Bouchekioua, A; Cervera, P; Coppo, P; de Wever, O; Douay, L; Gaulard, P; Gespach, C; Jeziorowska, D; Louache, F; Mercher, T; Nyga, R; Scourzic, L; Solary, E; Vainchenker, W; Zhang, Y | 1 |
| Lei, C; Shuyun, H; Xiangrong, C; Yiquan, K; Yongjun, Y; Zhilin, Y | 1 |
| Castiglioni, V; Cesca, M; Decio, A; Giavazzi, R; Rovida, A; Scanziani, E; Scarlato, V | 1 |
| Fujiwara, K; Fukuda, N; Kawata, N; Nagase, H; Obinata, D; Sato, A; Soma, M; Takahashi, S; Yamaguchi, K | 1 |
| Fujita, K; Hatano, K; Kawashima, A; Nakai, Y; Nakata, W; Nonomura, N; Sato, M; Takayama, H; Uemura, M; Yoshida, T | 1 |
| Ebos, JM; Francia, G; Guerin, E; Kerbel, RS; Lee, CR; Man, S; Xu, P | 1 |
| Babaian, KN; Hu, X; Kenney, PA; Lin, X; Maity, T; Merrill, MM; Su, SC; Wood, CG; Yang, SF; Zhang, XY | 1 |
| Cho, JY; Choi, SW; Heo, JN; Kim, SH; Lee, H; Lee, J; Lee, SY; Ryu, BJ; Yeon, JT | 1 |
| Ghalali, A; Högberg, J; Stenius, U; Wiklund, F; Zheng, H | 1 |
| Barbounis, V; Efremidis, A; Kostakis, ID; Koumakis, G; Lypas, G; Panopoulos, C; Tolia, M; Tryfonopoulos, D; Tsoukalas, N | 1 |
| Cho, Y; Je, DW; Ji, YG; Lee, DH; O, YM | 1 |
| Biddick, L; Kopelovich, L; Li, Q; Lightfoot, S; Madka, V; Mohammed, A; Patlolla, JM; Rao, CV; Steele, V; Wu, XR; Zhang, Y | 1 |
| Chou, A; Field, M; Gill, AJ; Hasovits, C; Hugh, TJ; Paik, J; Pavlakis, N; Toon, CW | 1 |
| Coquerel, B; Demange, E; Kassim, Y; Le Cerf, D; Perrot, V; Petit, A; Simon, T; Vannier, JP | 1 |
| Kosaka, T; Mikami, S; Mizuno, R; Okada, Y; Oya, M; Saya, H | 1 |
| Bubendorf, L; Erne, P; Frachet, A; Frismantiene, A; Kyriakakis, E; Maslova, K; Pfaff, D; Philippova, M; Resink, TJ; Ruiz, C; Vlajnic, T | 1 |
| Altuntaş, O; Güllü, İ; Petekkaya, İ; Süslü, N | 1 |
| Albuquerque, M; Benhadji, KA; de Gramont, A; Dos Santos, C; Faivre, S; Neuzillet, C; Paradis, V; Raymond, E; Serova, M; Tijeras-Raballand, A | 1 |
| Jeon, M; Kim, S; Lee, J; Lee, JE; Nam, SJ | 1 |
| Cao, Y; Cao, Z; Chen, X; Hosaka, K; Jensen, L; Liu, Y; Sun, Y; Wang, J; Yang, H; Zhuang, R | 1 |
| Beaumont, JL; Cella, D; Diaz, J; Khan, S; Lai, JS | 1 |
| Ju, RJ; Li, XT; Li, XY; Lu, WL; Mu, LM; Shi, JF; Sun, MG; Yan, Y; Zeng, F; Zhao, Y | 1 |
| Armstrong, AJ; Broderick, S; Eisen, T; Garcia, JA; George, DJ; Hainsworth, JD; Halabi, S; Hawkins, RE; Jones, RJ; Kollmannsberger, CK; Logan, TF; Lusk, CM; Oberg, S; Pickering, LM; Picus, J; Protheroe, A; Puzanov, I; Ryan, CW; Stadler, WM; Vaishampayan, UN | 1 |
| Furukawa, S; Handa, H; Hashimoto, A; Hashimoto, S; Mikami, S; Oikawa, T; Okada, Y; Onodera, Y; Oya, M; Sabe, H; Sugino, H; Yoshikawa, A | 1 |
| Fang, L; Jiang, K; Wang, D; Wang, J; Zhao, J; Zhu, L | 1 |
| Abe, H; Arai, K; Fukuda, T; Kamai, T; Masuda, A; Nukui, A; Yoshida, K | 1 |
| Jeong, YK; Jung, WG; Kim, EH; Lee, H | 1 |
| M, Eel D | 1 |
| Cheng, S; Dong, X; Gu, Q; Li, L; Lin, X; Liu, F; Liu, J; Sun, H; Sun, S; Wang, Y; Yao, N; Yao, Z; Zhang, D | 1 |
| Strumberg, D | 1 |
| Fromigué, O; Hamidouche, Z; Marie, PJ | 1 |
| Datta, PK; Halder, SK; Zhang, B; Zhang, S | 1 |
| Balleyguier, C; Celier, C; Escudier, B; Gautier, J; Medioni, J; Negrier, S; Oudard, S; Ravaud, A; Sablin, MP | 1 |
| Bjarnason, GA; Bukowski, RM; Chen, I; Figlin, RA; Garcia-del-Muro, X; Huang, X; Hutson, TE; Kim, ST; Michaelson, MD; Motzer, RJ; Negrier, S; Oudard, S; Pili, R; Solska, E; Sosman, JA; Szczylik, C; Thompson, JA; Tomczak, P; Wilding, G | 1 |
| Adachi, Y; Arimura, Y; Carbone, DP; Imai, K; Imsumran, A; Lee, CT; Li, H; Li, R; Min, Y; Piao, W; Shinomura, Y; Wang, Y; Yamamoto, H | 1 |
| McBride, D | 1 |
| Baritaki, S; Bonavida, B; Chapman, A; Palladino, M; Spandidos, DA; Yeung, K | 1 |
| Eisterer, W; Ploner, F | 1 |
| Cho, YJ; Datta, A; Datta, PK; Gorden, DL; Halder, SK; Kashikar, ND; Zhang, B | 1 |
| Hohenberger, P | 1 |
| Chioni, AM; Djamgoz, MB; Grose, R; Shao, D | 1 |
| Gajda, M; Kroeger, N; Petersen, I; Settmacher, U; Steiner, T; Wunderlich, H; Zanow, J | 1 |
| Fischer, BS; Gan, J; Ganapathi, R; Gong, J; Iyer, R; Masson, E; Mekhail, T; Patricia, D; Pursley, J; Williams, D | 1 |
| Antón, I; Calvo, A; Catena, R; Larzábal, L; Lecanda, F; Luis-Ravelo, D; Salazar-Colocho, P; Zandueta, C | 1 |
| Barbry, P; Fromigue, O; Hamidouche, Z; Lecanda, F; Mari, B; Marie, PJ; Patino, A; Vaudin, P | 1 |
| Abel, EJ; Brugarolas, J; Chapin, BF; Cost, NG; Culp, S; Delacroix, SE; Karam, JA; Margulis, V; Raj, GV; Sagalowsky, AI; Sleeper, JP; Smith, PJ; Wood, CG; Youssef, RF | 1 |
| Bex, A; Clarke, N | 1 |
| Reichardt, A; Reichardt, P | 1 |
| Cao, K; Chen, J; Guo, S; Huang, B; Li, X; Mao, X; Mo, C; Pan, J; Qiu, S; Wang, Z; Zhuang, J | 1 |
| Debus, J; Han, N; Huber, PE; Kleber, S; Lahn, M; Martin-Villalba, A; Peschke, P; Röhrich, M; Timke, C; Tuettenberg, J; Wirkner, U; Zhang, M | 1 |
| Kang, SG; Kim, SG; Lee, WH; Lee, YH; Lee, YS | 1 |
| Bussolino, F; Capano, S; Casanovas, O; Giacca, M; Giraudo, E; Maione, F; Regano, D; Serini, G; Zentilin, L | 1 |
| Chan, ES; Hansel, DE; Heston, WD; Larchian, WA; Patel, AR | 1 |
| Gong, K; Li, T; Ning, X; Wang, X; Wu, P; Zhang, C; Zhang, N | 1 |
| Asmar, L; Galsky, MD; Gardner, TA; Hahn, NM; Hellerstedt, BA; Hutson, TE; Kocs, D; Lerner, SP; McKenney, SA; Melnyk, AM; O'Rourke, M; Powles, T; Rauch, M; Sonpavde, G; Vogelzang, NJ; Wang, Y; Yu, M | 1 |
| Iljin, K; Kallioniemi, O; Ketola, K | 1 |
| Carranza, DC; Chen, IY; Collisson, EA; Kolodney, MS | 1 |
| Abdollahi, A; Debus, J; Hahnfeldt, P; Han, X; Hlatky, L; Howlett, AR; Huber, PE; Krempien, R; Lipson, KE; Trinh, T; Weber, KJ | 1 |
| Ledbetter, S; Pratt, BM; Teicher, BA; Walter-Yohrling, J | 1 |
| Bologna, M; Fabbro, D; Festuccia, C; Longo, M; MacKay, AR; Migliaccio, S; Recchia, I; Rucci, N; Susa, M; Teti, A | 1 |
| Collisson, EA; De, A; Gambhir, SS; Kleer, C; Kolodney, MS; Merajver, SD; Wu, M | 1 |
| Blake, RA; Chan, J; Harris, D; Howlett, AR; Kiewlich, D; Le, P; Liang, C; Lipson, KE; McMahon, G; Miller, T; Patel, N; Rice, A; Sun, L; Vasile, S; Wang, X | 1 |
| Anastasiadis, PZ; Fields, AP; Liu, Y; Thompson, EA; Zhang, J | 1 |
| Chen, B; Larsen, SH; Li, CY; Sun, HB; Wang, SY; Xu, WX; Yang, RF; Yang, X; Yue, PB; Zhan, YQ; Zheng, H | 1 |
| Barrio, J; Czernin, J; Halpern, BS; Mellinghoff, IK; Phelps, ME; Rozengurt, N; Safaei, A; Satyamurthy, N; Sawyers, CL; Silverman, DH; Stout, D; Tran, C; Waldherr, C; Weber, WA | 1 |
| Dominici, C; Mancini, C; Mancuso, M; McDowell, HP; Raschellà, G; Tanno, B; Vitali, R | 1 |
| Aggarwal, BB; Ahn, KS; Chao, TH; Chaturvedi, MM; Neuteboom, ST; Palladino, MA; Sethi, G; Younes, A | 1 |
| Christensen, JG; de Boüard, S; Gauduchon, P; Guillamo, JS; Herlin, P; Lemoisson, E; Raymond, E | 1 |
| Alba, E; Medina, MA; Quesada, AR | 1 |
| Brozmanova, K; Mardiak, J; Mego, M; Obertova, J; Reckova, M; Sycova-Mila, Z | 1 |
| Pinthus, J | 1 |
| Abbruzzese, JL; Chiao, PJ; Fleming, JB; Ishiyama, S; Melisi, D; Sclabas, GM; Tortora, G; Xia, Q | 1 |
| Fong, TA; Ge, S; Goldbrunner, R; Hirth, KP; Menger, MD; Rempel, SA; Schilling, L; Schmiedek, P; Tonn, JC; Ullrich, A; Vajkoczy, P; Vollmar, B | 1 |
7 review(s) available for pyrroles and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Preclinical recapitulation of antiangiogenic drug clinical efficacies using models of early or late stage breast cancer metastatis.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Clinical Trials, Phase III as Topic; Disease Models, Animal; Female; Heterografts; Humans; Indoles; Mice; Mice, Transgenic; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Neoplasm Transplantation; Pyrroles; Species Specificity; Sunitinib; Survival Analysis; Treatment Outcome | 2013 |
Renal cell carcinoma metastatic to the tongue: a case report and review of the literature.
Topics: Aged; Antineoplastic Agents; Biopsy; Carcinoma, Renal Cell; Follow-Up Studies; Glossectomy; Humans; Indoles; Interferon alpha-2; Interferon-alpha; Kidney Neoplasms; Male; Multimodal Imaging; Neoplasm Invasiveness; Palliative Care; Positron-Emission Tomography; Pyrroles; Recombinant Proteins; Sunitinib; Tomography, X-Ray Computed; Tongue Neoplasms | 2015 |
[Treatment of extensive disease].
Topics: Antineoplastic Agents; Benzamides; Clinical Trials as Topic; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Therapy, Combination; Follow-Up Studies; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Long-Term Care; Neoplasm Invasiveness; Piperazines; Pyrimidines; Pyrroles; Sunitinib | 2009 |
[Aspects of surgical treatment for gastro-intestinal stromal tumors].
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Benzamides; Combined Modality Therapy; Diagnostic Imaging; Disease Progression; Follow-Up Studies; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Laparoscopy; Minimally Invasive Surgical Procedures; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Staging; Piperazines; Pyrimidines; Pyrroles; Sunitinib | 2009 |
[Gastrointestinal stromal tumour (GIST): current standards in multimodal management].
Topics: Alleles; Benzamides; Chemotherapy, Adjuvant; Combined Modality Therapy; Disease-Free Survival; DNA Mutational Analysis; Exons; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Maintenance Chemotherapy; Neoplasm Invasiveness; Neoplasm Staging; Piperazines; Prognosis; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor alpha; Sunitinib | 2011 |
Early clinical data with small-molecule vascular endothelial growth factor tyrosine kinase receptor inhibitors.
Topics: Angiogenesis Inhibitors; Clinical Trials, Phase I as Topic; Female; Humans; Indoles; Lung Neoplasms; Male; Neoplasm Invasiveness; Neovascularization, Pathologic; Phthalazines; Prognosis; Pyridines; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Risk Assessment; Sunitinib; Treatment Outcome | 2004 |
Playing only one instrument may be not enough: limitations and future of the antiangiogenic treatment of cancer.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Indoles; Lung Neoplasms; Models, Biological; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; Pyridines; Pyrroles; Sorafenib; Sunitinib; Vascular Endothelial Growth Factor A | 2007 |
8 trial(s) available for pyrroles and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive breast cancer (FAKTION): a multicentre, randomised, controlled, phase 2 trial.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Double-Blind Method; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Fulvestrant; Humans; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Recurrence, Local; Prognosis; Pyrimidines; Pyrroles; Receptors, Estrogen; Salvage Therapy; Survival Rate | 2020 |
A phase II study of sunitinib in advanced hepatocellular carcinoma.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocellular; Disease Progression; Female; Humans; Indoles; Liver Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Pyrroles; Risk Assessment; Risk Factors; Sunitinib; Survival Analysis; Treatment Outcome | 2013 |
[In Process Citation].
Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Germany; Humans; Indoles; Ipilimumab; Kidney Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Nivolumab; Prognosis; Pyrroles; Societies, Medical; Sunitinib; Urology | 2015 |
Validation of a short questionnaire to measure symptoms and functional limitations associated with hand-foot syndrome and mucositis in patients with metastatic renal cell carcinoma.
Topics: Adult; Aged; Carcinoma, Renal Cell; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Hand-Foot Syndrome; Humans; Indazoles; Indoles; Kidney Neoplasms; Lymph Nodes; Male; Maximum Tolerated Dose; Middle Aged; Mucositis; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Pyrimidines; Pyrroles; Quality of Life; Risk Assessment; Sulfonamides; Sunitinib; Surveys and Questionnaires; Treatment Outcome | 2016 |
Everolimus versus sunitinib for patients with metastatic non-clear cell renal cell carcinoma (ASPEN): a multicentre, open-label, randomised phase 2 trial.
Topics: Adult; Aged; Carcinoma, Renal Cell; Confidence Intervals; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Everolimus; Female; Follow-Up Studies; Humans; Indoles; Kaplan-Meier Estimate; Kidney Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Proportional Hazards Models; Pyrroles; Sunitinib; Survival Analysis; Treatment Outcome | 2016 |
Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma.
Topics: Administration, Oral; Adult; Aged; Carcinoma, Renal Cell; Confidence Intervals; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Indoles; Injections, Subcutaneous; Interferon-alpha; Kaplan-Meier Estimate; Kidney Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Probability; Proportional Hazards Models; Pyrroles; Sunitinib; Survival Analysis; Treatment Outcome | 2009 |
Metabolism, excretion, and pharmacokinetics of oral brivanib in patients with advanced or metastatic solid tumors.
Topics: Administration, Oral; Aged; Alanine; Antineoplastic Agents; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Feces; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Pyrroles; Triazines | 2010 |
Gemcitabine, Cisplatin, and sunitinib for metastatic urothelial carcinoma and as preoperative therapy for muscle-invasive bladder cancer.
Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma, Transitional Cell; Cisplatin; Deoxycytidine; Female; Gemcitabine; Humans; Indoles; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; Pyrroles; Sunitinib; Survival Rate; Urinary Bladder Neoplasms; Urothelium | 2013 |
82 other study(ies) available for pyrroles and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Identification of TRPV4 as a novel target in invasiveness of colorectal cancer.
Topics: Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Epithelial-Mesenchymal Transition; Female; HCT116 Cells; Humans; Immunohistochemistry; Male; Middle Aged; Morpholines; Neoplasm Invasiveness; Neoplasm Metastasis; Proto-Oncogene Proteins c-akt; Pyrroles; Rectal Neoplasms; RNA, Small Interfering; Transfection; TRPV Cation Channels; Zinc Finger E-box-Binding Homeobox 1 | 2021 |
Epigallocatechin-3-gallate inhibits tumor angiogenesis: involvement of endoglin/Smad1 signaling in human umbilical vein endothelium cells.
Topics: Angiogenesis Inhibitors; Catechin; Cell Movement; Cell Proliferation; Cells, Cultured; Endoglin; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Neoplasm Invasiveness; Neovascularization, Pathologic; Pyrroles; Signal Transduction; Smad1 Protein; Vascular Endothelial Growth Factor A | 2019 |
Simultaneously inactivating Src and AKT by saracatinib/capivasertib co-delivery nanoparticles to improve the efficacy of anti-Src therapy in head and neck squamous cell carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzodioxoles; Biomarkers, Tumor; Cell Movement; Cell Proliferation; Drug Delivery Systems; Drug Resistance, Neoplasm; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Nanoparticles; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Quinazolines; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; src-Family Kinases; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2019 |
Puerarin inhibits hepatocellular carcinoma invasion and metastasis through miR-21-mediated PTEN/AKT signaling to suppress the epithelial-mesenchymal transition.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Disease Models, Animal; Drug Screening Assays, Antitumor; Epithelial-Mesenchymal Transition; Isoflavones; Liver Neoplasms; Male; MicroRNAs; Neoplasm Invasiveness; PTEN Phosphohydrolase; Pyrroles | 2020 |
Effects of Pyrrole-Imidazole Polyamides Targeting Human TGF-β1 on the Malignant Phenotypes of Liver Cancer Cells.
Topics: Cell Proliferation; Hep G2 Cells; Humans; Hyaluronan Receptors; Imidazoles; Liver Neoplasms; Neoplasm Invasiveness; Neoplastic Stem Cells; Nylons; Phenotype; Pyrroles; Spheroids, Cellular; Transforming Growth Factor beta1 | 2020 |
Therapeutic effects of blocking β-catenin against hepatocellular carcinoma-induced activation of inflammation, fibrosis and tumor invasion.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; beta Catenin; Cell Movement; Cytokines; Fibroblast Growth Factor 2; Fibrosis; Inflammation Mediators; Liver Neoplasms, Experimental; Male; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neovascularization, Pathologic; Pyridines; Pyrroles; Rats, Sprague-Dawley; Thiazolidinediones; Thioacetamide; Transforming Growth Factor beta1; Wnt Signaling Pathway | 2021 |
Role of AMPK and Akt in triple negative breast cancer lung colonization.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Cell Line, Tumor; Energy Metabolism; Female; Heterocyclic Compounds, 3-Ring; Humans; Lung Neoplasms; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Invasiveness; Neoplastic Cells, Circulating; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; RNA Interference; RNA, Small Interfering; Signal Transduction; Triple Negative Breast Neoplasms | 2021 |
Targeting Pyruvate Kinase M2 Phosphorylation Reverses Aggressive Cancer Phenotypes.
Topics: Active Transport, Cell Nucleus; Animals; Biomarkers, Tumor; Carrier Proteins; Cell Line, Tumor; Collagen; Cyclic N-Oxides; Drug Combinations; Genome, Human; Humans; Indolizines; Laminin; MCF-7 Cells; Membrane Proteins; Mice; Neoplasm Invasiveness; Neoplasm Transplantation; Neoplasms; Oxidation-Reduction; Phenotype; Phosphorylation; Protein Isoforms; Proteoglycans; Proteomics; Pyridazines; Pyridinium Compounds; Pyrroles; Pyruvate Kinase; Thyroid Hormone-Binding Proteins; Thyroid Hormones; Triple Negative Breast Neoplasms | 2021 |
SU6668 modulates prostate cancer progression by downregulating MTDH/AKT signaling pathway.
Topics: Angiogenesis Inhibitors; Cell Adhesion Molecules; Cell Line, Tumor; Cell Proliferation; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Indoles; Male; Membrane Proteins; Neoplasm Invasiveness; Oxindoles; Propionates; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Pyrroles; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Platelet-Derived Growth Factor beta; RNA-Binding Proteins; Signal Transduction; Vascular Endothelial Growth Factor Receptor-2 | 2017 |
Depletion of Tumor-Associated Macrophages with a CSF-1R Kinase Inhibitor Enhances Antitumor Immunity and Survival Induced by DC Immunotherapy.
Topics: Aminopyridines; Animals; Antigens, Neoplasm; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Dendritic Cells; Disease Models, Animal; Humans; Immunotherapy, Adoptive; Lung Neoplasms; Macrophages; Mesothelioma; Mesothelioma, Malignant; Neoplasm Invasiveness; Programmed Cell Death 1 Receptor; Protein Kinase Inhibitors; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor | 2017 |
Enhanced expression of caveolin-1 possesses diagnostic and prognostic value and promotes cell migration, invasion and sunitinib resistance in the clear cell renal cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Renal Cell; Caveolin 1; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Indoles; Kidney Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Prognosis; Pyrroles; Sunitinib; Young Adult | 2017 |
CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells.
Topics: Cell Division; Cell Line, Tumor; Cyclopentanes; Dimethyl Sulfoxide; Gingival Neoplasms; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Pyrroles; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; Sirtuin 1 | 2017 |
Bortezomib Alone and in Combination With Salinosporamid A Induces Apoptosis and Promotes Pheochromocytoma Cell Death In Vitro and in Female Nude Mice.
Topics: Adrenal Gland Neoplasms; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bortezomib; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Female; Lactones; Mice; Mice, Nude; Neoplasm Invasiveness; Neovascularization, Pathologic; Pheochromocytoma; Proteasome Inhibitors; Pyrroles | 2017 |
CXCR1 expression predicts benefit from tyrosine kinase inhibitors therapy in patients with metastatic renal cell carcinoma.
Topics: Aged; Biomarkers, Tumor; Carcinoma, Renal Cell; Female; Follow-Up Studies; Humans; Indoles; Kidney Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Niacinamide; Phenylurea Compounds; Prognosis; Protein Kinase Inhibitors; Pyrroles; Receptors, Interleukin-8A; Retrospective Studies; Sorafenib; Sunitinib; Survival Rate | 2018 |
VEGF pathway-targeting drugs induce evasive adaptation by activation of neuropilin-1/cMet in colon cancer cells.
Topics: Bevacizumab; Cell Movement; Colonic Neoplasms; Drug Resistance, Neoplasm; HCT116 Cells; Humans; Indoles; Neoplasm Invasiveness; Neuropilin-1; Proto-Oncogene Proteins c-met; Pyrroles; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor A | 2018 |
Effects of obatoclax combined with gemcitabine on the biological activity of pancreatic cancer cells under hypoxic conditions.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cadherins; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Deoxycytidine; Epithelial-Mesenchymal Transition; Gemcitabine; Humans; Indoles; Neoplasm Invasiveness; Pancreatic Neoplasms; Pyrroles; Tumor Suppressor Protein p53 | 2018 |
Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.
Topics: Animals; Cell Line, Tumor; Cell Nucleolus; Cell Proliferation; Chromatin; DNA, Ribosomal; Humans; Male; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Neoplasms; Peptide Elongation Factor 1; Promoter Regions, Genetic; Pyrimidines; Pyrroles; RNA Polymerase I; RNA Precursors; Survival Analysis; Transcription, Genetic; Xenograft Model Antitumor Assays | 2018 |
TRPV4 promotes the migration and invasion of glioma cells via AKT/Rac1 signaling.
Topics: Blotting, Western; Cell Line, Tumor; Cell Movement; Glioma; Humans; Leucine; Morpholines; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; Pyrroles; rac1 GTP-Binding Protein; Signal Transduction; Sulfonamides; TRPV Cation Channels | 2018 |
Obatoclax, a BH3 Mimetic, Enhances Cisplatin-Induced Apoptosis and Decreases the Clonogenicity of Muscle Invasive Bladder Cancer Cells via Mechanisms That Involve the Inhibition of Pro-Survival Molecules as Well as Cell Cycle Regulators.
Topics: bcl-X Protein; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Indoles; Neoplasm Invasiveness; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Urinary Bladder; Urinary Bladder Neoplasms | 2019 |
Antitumor efficacy of the heparanase inhibitor SST0001 alone and in combination with antiangiogenic agents in the treatment of human pediatric sarcoma models.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Bone Neoplasms; Cell Line, Tumor; Child; Drug Synergism; Female; Glucuronidase; Heparin; Humans; Indoles; Mice; Mice, Nude; Neoplasm Invasiveness; Neovascularization, Pathologic; Osteosarcoma; Pyrroles; Rhabdomyosarcoma; Sunitinib; Xenograft Model Antitumor Assays | 2013 |
JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Animals; Case-Control Studies; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Humans; Janus Kinase 3; Lymphoma, Extranodal NK-T-Cell; Male; Mice; Middle Aged; Mutation; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
Atorvastatin suppresses glioma invasion and migration by reducing microglial MT1-MMP expression.
Topics: Atorvastatin; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioblastoma; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; MAP Kinase Signaling System; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Microglia; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Pyrroles | 2013 |
Chemotherapy counteracts metastatic dissemination induced by antiangiogenic treatment in mice.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Lewis Lung; Cell Movement; Cisplatin; Deoxycytidine; Doxorubicin; Gemcitabine; Humans; Indoles; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Paclitaxel; Protein Kinase Inhibitors; Pyrroles; Sunitinib; Topotecan | 2013 |
Inhibition of MMP-9 using a pyrrole-imidazole polyamide reduces cell invasion in renal cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Blotting, Western; Carcinoma, Renal Cell; Cell Adhesion; Cell Division; Cell Proliferation; Female; Humans; Imidazoles; Immunoenzyme Techniques; Kidney Neoplasms; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Nylons; Prognosis; Pyrroles; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Tumor Cells, Cultured; Young Adult | 2013 |
EMMPRIN promotes angiogenesis, proliferation, invasion and resistance to sunitinib in renal cell carcinoma, and its level predicts patient outcome.
Topics: Adult; Aged; Aged, 80 and over; Animals; Apoptosis; Basigin; Blotting, Western; Carcinoma, Renal Cell; Cell Movement; Cell Proliferation; Down-Regulation; Drug Resistance, Neoplasm; Female; Humans; Immunoenzyme Techniques; Indoles; Kidney; Kidney Neoplasms; Male; Mice; Mice, Inbred BALB C; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Neovascularization, Pathologic; Pyrroles; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Sunitinib; Tumor Cells, Cultured | 2013 |
Autotaxin-lysophosphatidic acid signaling axis mediates tumorigenesis and development of acquired resistance to sunitinib in renal cell carcinoma.
Topics: Angiogenesis Inhibitors; Animals; Carcinogenesis; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Drug Resistance, Neoplasm; Female; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Kidney Neoplasms; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Nude; Microvessels; Neoplasm Invasiveness; Phosphoric Diester Hydrolases; Pyrroles; Signal Transduction; Sunitinib; Transcriptome; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
PF-3758309, p21-activated kinase 4 inhibitor, suppresses migration and invasion of A549 human lung cancer cells via regulation of CREB, NF-κB, and β-catenin signalings.
Topics: beta Catenin; Cell Line, Tumor; Cell Movement; Cyclic AMP Response Element-Binding Protein; Down-Regulation; Extracellular Matrix; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; p21-Activated Kinases; Pyrazoles; Pyrroles; Signal Transduction | 2014 |
Atorvastatin prevents ATP-driven invasiveness via P2X7 and EHBP1 signaling in PTEN-expressing prostate cancer cells.
Topics: Adenosine Triphosphate; Atorvastatin; Blotting, Western; Carrier Proteins; Cell Movement; Cell Nucleus; Cell Proliferation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoenzyme Techniques; Male; Neoplasm Invasiveness; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyrroles; Receptors, Purinergic P2X7; RNA, Small Interfering; Signal Transduction; Tumor Cells, Cultured | 2014 |
A collecting duct carcinoma producing carcinoembryonic antigen and Ca-125 in a 29-year-old woman.
Topics: Adult; Antineoplastic Agents; CA-125 Antigen; Carcinoembryonic Antigen; Carcinoma, Renal Cell; Female; Humans; Indoles; Kidney Neoplasms; Neoplasm Invasiveness; Positron-Emission Tomography; Pyrroles; Sunitinib; Tomography, X-Ray Computed | 2014 |
The inhibition of SRC family kinase suppresses pancreatic cancer cell proliferation, migration, and invasion.
Topics: Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; Neoplasm Invasiveness; Neoplasm Proteins; Pancreatic Neoplasms; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-hck; Proto-Oncogene Proteins c-yes; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; src-Family Kinases | 2014 |
Chemoprevention of urothelial cell carcinoma growth and invasion by the dual COX-LOX inhibitor licofelone in UPII-SV40T transgenic mice.
Topics: Animals; Antigens, Polyomavirus Transforming; Blotting, Western; Carcinoma in Situ; Cell Movement; Cell Proliferation; Female; Immunoenzyme Techniques; Lipoxygenase; Male; Mice; Mice, Transgenic; Neoplasm Invasiveness; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Pyrroles; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Urinary Bladder Neoplasms; Uroplakin II | 2014 |
Skin rash, a kidney mass and a family mystery dating back to World War II.
Topics: Adult; Alleles; Carcinoma, Renal Cell; Chromosome Deletion; Combined Modality Therapy; Drug Delivery Systems; Exanthema; Fumarate Hydratase; Genetic Counseling; Humans; Indoles; Kidney Medulla; Kidney Neoplasms; Leiomyomatosis; Liver Neoplasms; Lymph Node Excision; Lymphatic Metastasis; Male; Microfluidic Analytical Techniques; Multiplex Polymerase Chain Reaction; Neoplasm Invasiveness; Neoplasm Staging; Neoplasms, Multiple Primary; Nephrectomy; New South Wales; Oligonucleotide Array Sequence Analysis; Precision Medicine; Pyrroles; Rod Opsins; Skin; Skin Neoplasms; Sunitinib; World War II | 2014 |
Direct effect of bevacizumab on glioblastoma cell lines in vitro.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Autocrine Communication; Bevacizumab; Brain Neoplasms; Calcium Signaling; Cell Culture Techniques; Cell Division; Cell Line, Tumor; Cell Movement; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hyaluronic Acid; Hydrogels; Indoles; MAP Kinase Signaling System; Neoplasm Invasiveness; Neoplasm Proteins; Placenta Growth Factor; Pregnancy Proteins; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrroles; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2014 |
Expression of TNF-α and CD44 is implicated in poor prognosis, cancer cell invasion, metastasis and resistance to the sunitinib treatment in clear cell renal cell carcinomas.
Topics: Antineoplastic Agents; Cadherins; Carcinoma, Renal Cell; Cell Hypoxia; Cell Movement; Drug Resistance, Neoplasm; Gene Expression; Humans; Hyaluronan Receptors; Immunohistochemistry; Indoles; Kidney Neoplasms; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Prognosis; Pyrroles; Sunitinib; Tumor Necrosis Factor-alpha | 2015 |
EGFR and IGF-1R in regulation of prostate cancer cell phenotype and polarity: opposing functions and modulation by T-cadherin.
Topics: Cadherins; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Survival; Collagen; Drug Combinations; ErbB Receptors; Gefitinib; Gene Silencing; Golgi Apparatus; Humans; Laminin; Male; Neoplasm Invasiveness; Phenotype; Phosphorylation; Prostate; Prostatic Neoplasms; Proteoglycans; Pyrimidines; Pyrroles; Quinazolines; Receptor, IGF Type 1 | 2015 |
Effects of TGF-beta signalling inhibition with galunisertib (LY2157299) in hepatocellular carcinoma models and in ex vivo whole tumor tissue samples from patients.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cell Proliferation; Female; Hep G2 Cells; Humans; Immunohistochemistry; Indoles; Ki-67 Antigen; Liver Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Niacinamide; Phenylurea Compounds; Pyrazoles; Pyrroles; Quinolines; Signal Transduction; Sorafenib; Sunitinib; Transforming Growth Factor beta1 | 2015 |
Elevated TGF-β1 and -β2 expression accelerates the epithelial to mesenchymal transition in triple-negative breast cancer cells.
Topics: Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Movement; Enzyme-Linked Immunosorbent Assay; Epithelial-Mesenchymal Transition; Female; Fibronectins; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness; Pyrazoles; Pyrroles; RNA, Messenger; Signal Transduction; Snail Family Transcription Factors; Transcription Factors; Transforming Growth Factor beta1; Transforming Growth Factor beta2; Triple Negative Breast Neoplasms; Vimentin; Wound Healing | 2015 |
Invasiveness and metastasis of retinoblastoma in an orthotopic zebrafish tumor model.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Heterografts; Humans; Indoles; Mice; Morpholinos; Neoplasm Invasiveness; Neoplasm Metastasis; Neovascularization, Pathologic; Pyrroles; Retinoblastoma; Sunitinib; Vascular Endothelial Growth Factor A; Zebrafish | 2015 |
A Combination of Targeted Sunitinib Liposomes and Targeted Vinorelbine Liposomes for Treating Invasive Breast Cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Diffusion; Female; Indoles; Liposomes; Materials Testing; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Nanocapsules; Nanocomposites; Neoplasm Invasiveness; Particle Size; Pyrroles; Sunitinib; Surface Properties; Treatment Outcome; Tumor Burden; Vinblastine; Vinorelbine | 2015 |
Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.
Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Adult; Aged; Aged, 80 and over; Amides; Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; GTP-Binding Protein alpha Subunits, G12-G13; Guanine Nucleotide Exchange Factors; HEK293 Cells; Humans; Immunohistochemistry; Indoles; Isoxazoles; Kidney Neoplasms; Lysophospholipids; Male; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Nerve Tissue Proteins; Propionates; Pyridines; Pyrroles; Receptors, Lysophosphatidic Acid; Signal Transduction; Sirolimus; Sunitinib; Triazoles | 2016 |
Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma.
Topics: Animals; Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; Immunohistochemistry; Jumonji Domain-Containing Histone Demethylases; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Nuclear Proteins; Phosphorylation; Pyrazoles; Pyrroles; Repressor Proteins; RNA, Messenger; Smad2 Protein; Spheroids, Cellular | 2016 |
Higher preoperative serum levels of PD-L1 and B7-H4 are associated with invasive and metastatic potential and predictable for poor response to VEGF-targeted therapy and unfavorable prognosis of renal cell carcinoma.
Topics: Adult; Aged; Antineoplastic Agents; Axitinib; B7-H1 Antigen; Biomarkers, Tumor; Carcinoma, Renal Cell; CD28 Antigens; Chemotherapy, Adjuvant; Female; Humans; Imidazoles; Indazoles; Indoles; Kaplan-Meier Estimate; Karnofsky Performance Status; Kidney Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Proteins; Nephrectomy; Preoperative Period; Prognosis; Pyrroles; Retrospective Studies; Sunitinib; Treatment Outcome; V-Set Domain-Containing T-Cell Activation Inhibitor 1; Vascular Endothelial Growth Factor A; Young Adult | 2016 |
Mechanisms of SU5416, an inhibitor of vascular endothelial growth factor receptor, as a radiosensitizer for colon cancer cells.
Topics: Adenocarcinoma; Aging; Antineoplastic Agents; Apoptosis; beta-Galactosidase; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; DNA Repair; HCT116 Cells; HT29 Cells; Humans; Indoles; Neoplasm Invasiveness; Pyrroles; Radiation Tolerance; Radiation-Sensitizing Agents; Reactive Oxygen Species; Receptors, Vascular Endothelial Growth Factor | 2016 |
Utilization of Sunitinib for Renal Cell Cancer: an Egyptian University hospital experience.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Papillary; Carcinoma, Renal Cell; Egypt; Female; Follow-Up Studies; Hospitals, University; Humans; Indoles; Kidney Neoplasms; Male; Middle Aged; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Prognosis; Pyrroles; Sunitinib; Survival Rate; Young Adult | 2016 |
Anti-angiogenic treatment promotes triple-negative breast cancer invasion via vasculogenic mimicry.
Topics: Adult; Aged; Angiogenesis Inhibitors; Animals; Antigens, CD; Breast; Cadherins; Cell Line, Tumor; Female; Fluorescent Antibody Technique; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Matrix Metalloproteinase 2; Mice; Mice, Inbred BALB C; Mice, Nude; Microcirculation; Middle Aged; Neoplasm Invasiveness; Neovascularization, Pathologic; Nuclear Proteins; Pyrroles; Sunitinib; Tissue Array Analysis; Treatment Outcome; Triple Negative Breast Neoplasms; Twist-Related Protein 1; Up-Regulation; Xenograft Model Antitumor Assays | 2017 |
Efficacy of sunitinib and sorafenib in non-clear cell renal cell carcinoma: results from expanded access studies.
Topics: Benzenesulfonates; Carcinoma, Renal Cell; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Indoles; Kidney Neoplasms; Male; Maximum Tolerated Dose; Multicenter Studies as Topic; Neoplasm Invasiveness; Neoplasm Staging; Niacinamide; Phenylurea Compounds; Prognosis; Pyridines; Pyrroles; Randomized Controlled Trials as Topic; Risk Assessment; Sorafenib; Sunitinib; Survival Analysis; Treatment Outcome | 2008 |
Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion.
Topics: Animals; Apoptosis; Atorvastatin; Cell Line, Tumor; Cell Movement; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; MAP Kinase Kinase 4; MAP Kinase Signaling System; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Osteosarcoma; Phosphorylation; Proto-Oncogene Proteins c-jun; Pyrroles; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Tissue Inhibitor of Metalloproteinase-2 | 2008 |
Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer.
Topics: Animals; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Genes, ras; Humans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mutation; Neoplasm Invasiveness; Pyrazoles; Pyrroles; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2009 |
Sequential sorafenib and sunitinib for renal cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Carcinoma, Renal Cell; Cohort Studies; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Follow-Up Studies; Humans; Indoles; Kaplan-Meier Estimate; Kidney Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Niacinamide; Phenylurea Compounds; Probability; Pyridines; Pyrroles; Retrospective Studies; Risk Assessment; Sorafenib; Sunitinib; Survival Analysis; Treatment Outcome | 2009 |
Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers via blocking production of matrilysin.
Topics: Adenocarcinoma; Animals; Blotting, Western; Female; Fluorescent Antibody Technique; Gastrointestinal Neoplasms; Genes, Dominant; Humans; Immunoenzyme Techniques; Immunoprecipitation; Infusions, Subcutaneous; Matrix Metalloproteinase 7; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Somatomedins; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2009 |
New study sheds light on angiogenesis inhibitors.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Humans; Indoles; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Pyrroles; Sunitinib | 2009 |
Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction.
Topics: Cell Differentiation; Cell Line, Tumor; Cell Movement; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Lactones; Male; Mesoderm; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Phosphatidylethanolamine Binding Protein; Prostatic Neoplasms; Protease Inhibitors; Proteasome Inhibitors; Pyrroles; Snail Family Transcription Factors; Transcription Factors | 2009 |
Antimetastatic role of Smad4 signaling in colorectal cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Female; Humans; Liver Neoplasms; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Invasiveness; NM23 Nucleoside Diphosphate Kinases; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad4 Protein; Time Factors; Transfection; Transforming Growth Factor beta1; Urokinase-Type Plasminogen Activator | 2010 |
Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migration.
Topics: Animals; Breast Neoplasms; Carbazoles; Cell Line, Tumor; Cell Movement; Colforsin; Cyclic AMP-Dependent Protein Kinases; Feedback, Physiological; Gene Expression Regulation, Neoplastic; Humans; Infant, Newborn; Muscle Proteins; NAV1.5 Voltage-Gated Sodium Channel; Neoplasm Invasiveness; Phosphorylation; Pyrroles; Rats; Sodium Channels; Stromal Cells; Tetrodotoxin; Up-Regulation | 2010 |
Downsizing a tumor thrombus of advanced renal cell carcinoma with neoadjuvant systemic therapy and resulting histopathological effects.
Topics: Antineoplastic Agents; Carcinoma, Renal Cell; Chemotherapy, Adjuvant; Humans; Indoles; Kidney Neoplasms; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplastic Cells, Circulating; Nephrectomy; Pyrroles; Sunitinib; Thrombectomy; Tomography, X-Ray Computed; Treatment Outcome; Vena Cava, Inferior; Venous Thrombosis | 2010 |
PDGFR signaling blockade in marrow stroma impairs lung cancer bone metastasis.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Bone Marrow Cells; Bone Neoplasms; Cell Adhesion; Cell Line; Cell Proliferation; Gene Expression Profiling; Humans; Indoles; Lung Neoplasms; Mice; Neoplasm Invasiveness; Pyrroles; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Stromal Cells; Sunitinib | 2011 |
CYR61 downregulation reduces osteosarcoma cell invasion, migration, and metastasis.
Topics: Animals; Apoptosis; Atorvastatin; Bone and Bones; Cell Line; Cell Movement; Cell Proliferation; Cell Survival; Cysteine-Rich Protein 61; Down-Regulation; Gene Expression Regulation, Neoplastic; Heptanoic Acids; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Osteosarcoma; Prenylation; Pyrroles | 2011 |
The impact of targeted molecular therapies on the level of renal cell carcinoma vena caval tumor thrombus.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Carcinoma, Renal Cell; Chemotherapy, Adjuvant; Chi-Square Distribution; Drug Administration Schedule; Female; Humans; Indoles; Kidney Neoplasms; Male; Middle Aged; Molecular Targeted Therapy; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Staging; Nephrectomy; Patient Selection; Proportional Hazards Models; Protein Kinase Inhibitors; Pyrroles; Radiography; Retrospective Studies; Risk Assessment; Risk Factors; Sunitinib; Texas; Thrombectomy; Time Factors; Treatment Outcome; Tumor Burden; Vena Cava, Inferior; Venous Thrombosis | 2011 |
Targeted caval cytoreduction: solid foundations or shifting sands?
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Carcinoma, Renal Cell; Chemotherapy, Adjuvant; Drug Administration Schedule; Evidence-Based Medicine; Humans; Indoles; Kidney Neoplasms; Molecular Targeted Therapy; Neoadjuvant Therapy; Neoplasm Invasiveness; Nephrectomy; Patient Selection; Protein Kinase Inhibitors; Pyrroles; Risk Assessment; Risk Factors; Sunitinib; Thrombectomy; Time Factors; Treatment Outcome; Tumor Burden; Vena Cava, Inferior; Venous Thrombosis | 2011 |
The expression and role of protein kinase C (PKC) epsilon in clear cell renal cell carcinoma.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biomarkers, Tumor; Blotting, Western; Carcinoma, Renal Cell; Caspase 3; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colony-Forming Units Assay; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Immunoenzyme Techniques; Indoles; Kidney Neoplasms; Male; Middle Aged; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Protein Kinase C-epsilon; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Sunitinib; Wound Healing | 2011 |
Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA Damage; DNA Repair; Glioblastoma; Humans; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, SCID; Microarray Analysis; Neoplasm Invasiveness; Neoplastic Stem Cells; Neovascularization, Pathologic; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Radiation Tolerance; Radiation-Sensitizing Agents; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta; Xenograft Model Antitumor Assays | 2011 |
Hypoxia-inducible factor-1α inhibition by a pyrrolopyrazine metabolite of oltipraz as a consequence of microRNAs 199a-5p and 20a induction.
Topics: Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cobalt; HT29 Cells; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; MicroRNAs; Neoplasm Invasiveness; Neovascularization, Pathologic; Pyrazines; Pyridazines; Pyrroles; Thiones; Thiophenes | 2012 |
Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice.
Topics: Angiogenesis Inhibitors; Animals; Cell Hypoxia; Combined Modality Therapy; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Female; Genetic Therapy; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Liver Neoplasms; Lymphatic Metastasis; Mice; Mice, Transgenic; Neoplasm Invasiveness; Neovascularization, Physiologic; Neuroendocrine Tumors; NF-kappa B; Pancreatic Neoplasms; Pericytes; Proto-Oncogene Proteins c-met; Pyrroles; Recombinant Proteins; Semaphorin-3A; Sunitinib; Tumor Burden; Uterine Cervical Neoplasms | 2012 |
Sunitinib malate provides activity against murine bladder tumor growth and invasion in a preclinical orthotopic model.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Humans; Indoles; Mice; Mice, Inbred C3H; Neoplasm Invasiveness; Pyrroles; Sunitinib; Urinary Bladder Neoplasms | 2012 |
The erythropoietin/erythropoietin receptor signaling pathway promotes growth and invasion abilities in human renal carcinoma cells.
Topics: Animals; Apoptosis; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Erythropoietin; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Indoles; Kidney Neoplasms; Matrix Metalloproteinase 2; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Protein Kinase Inhibitors; Pyrroles; Receptors, Erythropoietin; Recombinant Proteins; Signal Transduction; Sunitinib | 2012 |
Chemical biology drug sensitivity screen identifies sunitinib as synergistic agent with disulfiram in prostate cancer cells.
Topics: Apoptosis; Cadherins; Cell Line, Tumor; Cell Movement; Cell Survival; Disulfiram; Drug Screening Assays, Antitumor; Drug Synergism; High-Throughput Screening Assays; Humans; Indoles; Male; Neoplasm Invasiveness; Oncogene Proteins, Fusion; Prostate-Specific Antigen; Prostatic Neoplasms; Pyrroles; Receptors, Androgen; Signal Transduction; Sunitinib | 2012 |
Isoprenylation is necessary for the full invasive potential of RhoA overexpression in human melanoma cells.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Biocompatible Materials; Cell Movement; Collagen; Drug Combinations; Gene Expression Regulation, Neoplastic; Heptanoic Acids; Humans; Laminin; Melanoma; Neoplasm Invasiveness; Neoplasm Metastasis; Protein Prenylation; Protein Processing, Post-Translational; Proteoglycans; Pyrroles; rhoA GTP-Binding Protein; Signal Transduction; Skin Neoplasms; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro.
Topics: Angiogenesis Inhibitors; Cell Division; Cells, Cultured; Dose-Response Relationship, Radiation; Endothelial Growth Factors; Endothelium, Vascular; Fibroblast Growth Factor 2; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Kinetics; Lymphokines; Male; Neoplasm Invasiveness; Neovascularization, Pathologic; Oxindoles; Particle Accelerators; Propionates; Prostatic Neoplasms; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; X-Rays | 2003 |
Myofibroblasts enable invasion of endothelial cells into three-dimensional tumor cell clusters: a novel in vitro tumor model.
Topics: Adult; Angiogenesis Inhibitors; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cells, Cultured; Endothelial Cells; Fibroblasts; Humans; Immunohistochemistry; Indoles; Metalloproteases; Neoplasm Invasiveness; Neoplasms; Oxindoles; Paclitaxel; Propionates; Protease Inhibitors; Pyrroles; Stromal Cells | 2003 |
Pyrrolopyrimidine c-Src inhibitors reduce growth, adhesion, motility and invasion of prostate cancer cells in vitro.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Adhesion; Cell Division; Cell Movement; Cell Size; CSK Tyrosine-Protein Kinase; Drug Screening Assays, Antitumor; Humans; Male; Matrix Metalloproteinases; Neoplasm Invasiveness; Prostatic Neoplasms; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; src-Family Kinases; Tumor Cells, Cultured | 2003 |
Atorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human melanoma cells.
Topics: Animals; Atorvastatin; Cell Movement; Green Fluorescent Proteins; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Immunoblotting; Immunohistochemistry; Luciferases; Luminescent Proteins; Melanoma; Mice; Mice, SCID; Microscopy, Fluorescence; Neoplasm Invasiveness; Neoplasm Metastasis; Plasmids; Protein Processing, Post-Translational; Pyrroles; ras Proteins; rho GTP-Binding Proteins; rhoC GTP-Binding Protein; Serum Response Factor; Subcellular Fractions; Time Factors; Tumor Cells, Cultured | 2003 |
Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion.
Topics: Binding Sites; Cell Division; Cell Line, Tumor; Cell Movement; Enzyme Inhibitors; Hepatocyte Growth Factor; Humans; Indoles; Models, Molecular; Neoplasm Invasiveness; Neoplasms; Phosphorylation; Phosphotyrosine; Protein Conformation; Proto-Oncogene Proteins c-met; Pyrroles; Signal Transduction | 2003 |
Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway.
Topics: Animals; Apoptosis Regulatory Proteins; Butadienes; Carrier Proteins; Cell Line; Colonic Neoplasms; Cyclooxygenase 2; Enzyme Activation; Enzyme Inhibitors; Genes, Dominant; Genetic Predisposition to Disease; Glutathione Transferase; GTP-Binding Proteins; Humans; Intestinal Mucosa; Intracellular Signaling Peptides and Proteins; Isoenzymes; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Membrane Proteins; Mesylates; Models, Biological; Mutation; Neoplasm Invasiveness; Nitriles; p21-Activated Kinases; Phenotype; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Kinase C beta; Protein Serine-Threonine Kinases; Pyrroles; rac1 GTP-Binding Protein; ras Proteins; Rats; Retroviridae; Signal Transduction; Transfection | 2004 |
SU5416 is a potent inhibitor of hepatocyte growth factor receptor (c-Met) and blocks HGF-induced invasiveness of human HepG2 hepatoma cells.
Topics: 3T3 Cells; Animals; Carcinoma, Hepatocellular; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Gene Expression; Hepatocyte Growth Factor; Hepatocytes; Humans; Indoles; Liver Neoplasms; Mice; Neoplasm Invasiveness; Oncogene Proteins, Fusion; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Pyrroles; Tyrosine | 2004 |
Monitoring antiproliferative responses to kinase inhibitor therapy in mice with 3'-deoxy-3'-18F-fluorothymidine PET.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Dideoxynucleosides; Disease Models, Animal; Fluorodeoxyglucose F18; Humans; Mice; Mice, SCID; Neoplasm Invasiveness; Positron-Emission Tomography; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Radiopharmaceuticals; Treatment Outcome | 2005 |
Down-regulation of insulin-like growth factor I receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo.
Topics: Adrenal Gland Neoplasms; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Proliferation; Down-Regulation; Humans; Kidney Neoplasms; Male; Mice; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Neuroblastoma; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Transplantation, Heterologous; Tumor Burden; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2006 |
Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Cell Differentiation; Cell Line; Down-Regulation; Enzyme Activation; Gene Expression Regulation; Genes, Reporter; Humans; I-kappa B Proteins; Lactones; Mice; Mice, Knockout; Neoplasm Invasiveness; NF-kappa B; Osteoclasts; Phosphorylation; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles; RANK Ligand; Time Factors; Tumor Necrosis Factors | 2007 |
Antiangiogenic and anti-invasive effects of sunitinib on experimental human glioblastoma.
Topics: Angiogenesis Inhibitors; Animals; Blotting, Western; Brain; Brain Neoplasms; Cell Line, Tumor; Flow Cytometry; Focal Adhesion Protein-Tyrosine Kinases; Glioblastoma; Humans; Immunohistochemistry; Immunoprecipitation; Indoles; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Neovascularization, Pathologic; Organ Culture Techniques; Phosphorylation; Pyrroles; src-Family Kinases; Sunitinib; Xenograft Model Antitumor Assays | 2007 |
Increased cardiotoxicity of sorafenib in sunitinib-pretreated patients with metastatic renal cell carcinoma.
Topics: Aged; Atrial Fibrillation; Benzenesulfonates; Carcinoma, Renal Cell; Cardiovascular Diseases; Chest Pain; Drug Interactions; Follow-Up Studies; Humans; Indoles; Kidney Neoplasms; Middle Aged; Myocardial Ischemia; Neoplasm Invasiveness; Neoplasm Staging; Niacinamide; Phenylurea Compounds; Pyridines; Pyrroles; Risk Assessment; Sampling Studies; Severity of Illness Index; Sorafenib; Sunitinib | 2007 |
Editorial comment on: Metastin inhibits migration and invasion of renal cell carcinoma with overexpression of metastin receptor.
Topics: Antineoplastic Agents; Carcinoma, Renal Cell; Cell Movement; Humans; Indoles; Kisspeptins; Matrix Metalloproteinase Inhibitors; Molecular Biology; Neoplasm Invasiveness; Pyrroles; Receptors, G-Protein-Coupled; Receptors, Kisspeptin-1; Sunitinib; Treatment Outcome; Tumor Suppressor Proteins | 2009 |
LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis.
Topics: Animals; Anoikis; Antimetabolites, Antineoplastic; Apoptosis; Cell Movement; Deoxycytidine; Drug Therapy, Combination; Gemcitabine; Humans; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Invasiveness; Neovascularization, Pathologic; Pancreatic Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Ribonucleotide Reductases; Signal Transduction; Smad2 Protein; Survival Rate; Transforming Growth Factor beta; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2008 |
Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC.
Topics: Angiogenesis Inhibitors; Animals; Biomarkers, Tumor; Cell Division; Cell Movement; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glioma; Immunohistochemistry; Indoles; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Microscopy, Video; Neoplasm Invasiveness; Neoplasm Transplantation; Neovascularization, Pathologic; Osteonectin; Pyrroles; Rats; Solvents; Time Factors; Tumor Cells, Cultured | 2000 |