pyrroles has been researched along with Experimental Neoplasms in 101 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 17 (16.83) | 18.7374 |
1990's | 5 (4.95) | 18.2507 |
2000's | 24 (23.76) | 29.6817 |
2010's | 48 (47.52) | 24.3611 |
2020's | 7 (6.93) | 2.80 |
Authors | Studies |
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Feng, Z; Gao, C; He, H; Li, X; Liu, Z; Ran, K; Shi, Y; Wang, N; Wei, W; Ye, T; Yu, L; Zhu, Y | 1 |
Ding, L; Huang, T; Jiang, H; Liang, Y; Liu, Y; Sattar, S; Shang, Y; Wang, M; Wei, Y; Wu, B; Yang, T; Zhang, D; Zhou, F | 1 |
Cong, L; Dong, J; Ke, M; Li, Y; Lv, Y; Wang, X; Zhang, Z; Zhao, S; Zhu, Y | 1 |
Geng, S; Yang, X; Zhan, G; Zhao, H; Zhao, Y | 1 |
Andreeva, DV; Dezhenkova, LG; Kaluzhny, DN; Litvinova, VA; Moisenovich, MM; Ramonova, AA; Schols, D; Shchekotikhin, AE; Shtil, AA; Tikhomirov, AS; Treshalin, ID; Tsvetkov, VB; Volodina, YL | 1 |
Chen, Z; Fan, Q; Hu, X; Li, T; Zhang, R; Zheng, Z | 1 |
Deng, Q; Huang, Y; Jin, X; Liu, Z; Qing, W; Xing, X | 1 |
Bouakaz, A; Chen, J; Feng, Y; Qin, D; Wan, M; Wu, D; Zhang, L; Zhu, H | 1 |
Cheng, B; Cheng, Y; Ding, Z; Fang, L; Li, H; Li, M; Li, Y; Lin, X; Liu, K; Lu, D; Shao, X; Shi, W; Su, W; Wu, C; Zhang, J | 1 |
Agalou, A; Argyros, O; Asvos, X; Beis, D; Davos, CH; Fokas, D; Karampelas, T; Papakyriakou, A; Tamvakopoulos, C; Varela, A | 1 |
Alon, L; Bar-Shir, A; Bulte, JWM; Gilad, AA; Kato, Y; Korrer, MJ; Lim, HS; Pathak, AP; Yadav, NN | 1 |
Bao, Y; Cao, Y; Huang, Y; Li, Y; Liu, L; Sun, L; Yang, X; Yi, J; Yu, C | 1 |
Beauvineau, C; Busser, B; Coll, JL; Falson, P; Fernando Díaz, J; Frachet, V; Gilson, P; Hurbin, A; Josa-Prado, F; Lafanechère, L; Mahuteau-Betzer, F; Moreno, A; Naud-Martin, D; Vanwonterghem, L | 1 |
Dong, X; Liang, P; Si, W; Wang, P; Wang, Y; Xu, H; Zhang, Y; Zou, J | 1 |
Cao, H; Gao, Y; Jiang, X; Liu, Y; Qu, Z; Sun, H | 1 |
Xie, Z; Zhang, T; Zhang, W; Zheng, M | 1 |
Cai, C; Hu, Y; Lu, S; Peng, C; Popovtzer, R; Shen, M; Shi, X; Sun, W; Yu, J; Zhou, Y | 1 |
Jin, Y; Tian, J; Yang, X | 1 |
He, H; Liu, S; Shuai, X; Wang, Y; Xie, Z; Yu, M; Zheng, M; Zheng, X | 1 |
Cao, Y; Guo, Y; Kang, Y; Li, CM; Li, W; Liu, H; Lu, SY; Ran, HT; Wang, J; Wang, X; Wang, ZG | 1 |
Morton, D; Nambiar, PR | 1 |
Behrendt, FF; Bzyl, J; Mottaghy, FM; Palmowski, K; Palmowski, M; Rix, A; Verburg, FA; Winz, O | 1 |
Banerjee, S; Baral, R; Barik, S; Bhuniya, A; Bose, A; Das, A; Ghosh, S; Ghosh, T; Pal, S; Paul, T; Roy, S; Sarkar, M | 1 |
Dai, Z; Jin, Y; Qu, E; Wang, J; Wang, S; Zha, Z; Zhang, S | 1 |
Bremer, C; Budny, T; Hahnenkamp, A; Heindel, W; Persigehl, T; Remmele, S; Ring, J; Schwartz, LH; Spiegel, HU; Stoeppeler, S | 1 |
Beraldi, E; Crafter, C; Davies, BR; Fazli, L; Gleave, ME; Kim, S; Lamoureux, F; Thaper, D; Thomas, C; Zoubeidi, A | 1 |
Blackwood, E; Del Nagro, C; Evangelista, M; Jackson, PK; Kowanetz, K; Malek, S; O'Brien, T; Ramiscal, J; Xiao, Y | 1 |
Dai, Z; Qu, E; Wang, J; Wang, S; Zha, Z; Zhang, S; Zhang, Y | 1 |
Behrendt, FF; Gray, BD; Kiessling, F; Lederle, W; Mottaghy, FM; Pak, KY; Palmowski, K; Palmowski, M; Rix, A | 1 |
Awad, GA; El-Safoury, DM; Motaleb, MA; Sakr, TM | 1 |
Dong, Z; Imai, A; Krishnamurthy, S; Nör, JE; Zeitlin, BD; Zhang, Z | 1 |
Bize, PE; Borchard, G; Denys, A; Doelker, E; Dormond, O; Fuchs, K; Jordan, O | 1 |
Conney, AH; Cui, XX; Ding, N; Du, Z; Gao, Z; Hu, C; Huang, H; Lin, Y; Rabson, AB; Shih, WJ; Wei, X; Zheng, X | 1 |
Bernhardt, A; Fallon, J; Greiner, JW; Guzman, W; Kradjian, G; Lan, Y; Neuteboom, B; Sabzevari, H; Schlom, J; Tighe, R | 1 |
Fan, C; Gong, X; Yang, Y; Zhang, L; Zhao, S; Zheng, Q; Zhou, H | 1 |
Arlot-Bonnemains, Y; Belaud-Rotureau, MA; Bensalah, K; Collet, N; Dolley-Hitze, T; Jouan, F; Lavenu, A; Oger, E; Rioux-Leclercq, N; Verhoest, G; Vigneau, C | 1 |
Avanzi, N; Ballinari, D; Bandiera, T; Bertrand, J; Bindi, S; Brasca, MG; Canevari, G; Carenzi, D; Casero, D; Ceriani, L; Ciomei, M; Cirla, A; Colombo, M; Cribioli, S; Cristiani, C; Della Vedova, F; Donati, D; Fachin, G; Fasolini, M; Felder, ER; Galvani, A; Gnocchi, P; Isacchi, A; Mirizzi, D; Motto, I; Nesi, M; Panzeri, A; Pesenti, E; Vianello, P | 1 |
Coplin, MA; Donahue, RN; Farsaci, B; Grenga, I; Hodge, JW; Lepone, LM; Molinolo, AA | 1 |
Balansky, R; D'Agostini, F; De Flora, S; Ganchev, G; Iltcheva, M; La Maestra, S; Micale, RT; Nikolov, M; Steele, VE | 1 |
Baldini, C; Bridal, SL; Comperat, E; Dizeux, A; Lamuraglia, M; Le Guillou-Buffello, D; Lucidarme, O; Payen, T | 1 |
Taieb, J; Tartour, É; Terme, M; Voron, T | 1 |
Choi, EK; Jeong, SY; Kim, J; Kim, N; Koo, HJ; Lee, JS; Lee, M; Woo, CW | 1 |
Boos, A; Chen, B; Fairhurst, RA; Furet, P; Guagnano, V; Jeay, S; Jiang, S; Lu, W; Marsilje, TH; McCarthy, C; Michellys, PY; Niklaus, M; Schnell, C; Stauffer, F; Stutz, S; Vaupel, A | 1 |
Andrews, KL; Booker, SK; Cee, VJ; Chavez, F; Chen, J; Chen, Y; Eastwood, H; Guerrero, N; Herberich, B; Hickman, D; Lanman, BA; Laszlo, J; Lee, MR; Lipford, JR; Mattson, B; Mohr, C; Nguyen, Y; Norman, MH; Pettus, LH; Powers, D; Reed, AB; Rex, K; Sastri, C; Tamayo, N; Tasker, AS; Wang, HL; Wang, P; Winston, JT; Wu, B; Wu, T; Wurz, RP; Xu, Y; Zhou, Y | 1 |
Arosio, D; Battistini, L; Bianchini, F; Calorini, L; Portioli, E; Pupi, A; Sartori, A; Vacondio, F; Zanardi, F | 1 |
Guan, XY; Huang, XR; Lan, HY; Li, CJ; Lian, GY; Meng, XM; Tang, PM; Tang, YJ; To, KF; Wang, QM; Yan, BP; Zhou, S | 1 |
Angeles, TS; Mallamo, JP; Tripathy, R; Yang, SX | 1 |
Ajith, TA; Anu, V; Riji, T | 1 |
Dabora, SL; Lee, N; Messina, MP; Nobil, AM; Rauktys, AE; Woodrum, CL | 1 |
Arregi, A; Azpiroz, A; Beitia, G; Garmendia, L; Vegas, O | 1 |
Suddek, GM | 1 |
Christensen, JG; Esparza, CO; Feng, J; Hu-Lowe, DD; Lee, JH; Plumlee, PA; Shojaei, F; Simmons, BH; Stewart, AE; Wong, A | 1 |
Jiao, XD; Li, R; Su, B; Takayama, K; Wang, JJ; Zhang, HP | 1 |
Farsaci, B; Higgins, JP; Hodge, JW | 1 |
Belisario, DC; Bolli, E; Bosia, A; Calogero, RA; Cavallo, F; Pinto, H; Riganti, C | 1 |
Calcinaro, F; D'Agostino, M; Durante, C; Filetti, S; Moretti, S; Puxeddu, E; Rhoden, K; Russo, D; Sponziello, M; Tallini, G; Tamburrano, G; Voce, P | 1 |
Berman, JN; Colpitts, J; Corkery, DP; Dellaire, G; Forrester, AM; McFarland, SA; Smithen, DA; Thompson, A | 1 |
Dai, Z; Ren, Q; Yue, X; Zha, Z | 1 |
Czarnota, GJ; El Kaffas, A; Giles, A | 1 |
Baker, CH; Bucana, CD; Fidler, IJ; Kedar, D; McCarty, MF; Tsan, R; Weber, KL | 1 |
Gallo, JM; Guo, P; Li, S; Ma, J; Reed, K | 1 |
Donnelly, E; Geng, L; Hallahan, DE; Himmelfarb, E; McMahon, G; Mendel, D; Schueneman, AJ; Tan, J | 1 |
Bäckman, U; Christofferson, R; Svensson, A | 1 |
LEPESHKINA, GN; ROSSOLIMO, OK; STANISLAVSKAIA, MS | 1 |
FINGER, H; FRETZDORFF, AM; SCHNEIDER, F; SEYNSCHE, K; WEITZEL, G | 1 |
CAMPBELL, GW; DULANEY, EL; GITTERMAN, CO; HENDLIN, D; KACZKA, EA; WOODRUFF, HB | 1 |
MAN'KO, IV; PETROVA, MF; PUKHAL'SKAIA, ACh | 1 |
French, KJ; Lee, BD; Smith, CD; Zhuang, Y | 1 |
Engel, JB; Halmos, G; Hammann, B; Keller, G; Nagy, A; Schally, AV | 1 |
Fu, M; Guo, S; Li, S; Liang, X; Lin, C; Lu, H; Wu, M; Zhang, X; Zheng, Z | 1 |
Chowbay, B; Lye, KY; Moore, S; Olivo, M; Sharma, A; Zhou, Q | 1 |
Garcia-Echeverria, C | 1 |
Jiang, XT; Tao, HQ; Zou, SC | 1 |
Bibby, MC; Burger, AM; Fiebig, HH; Loadman, PM; Schultz, R; Thurston, DE | 1 |
Boschi, F; D'Onofrio, M; Faccioli, N; Marzola, P; Pozzi Mucelli, R; Sbarbati, A | 1 |
Alaoui-Jamali, MA; Chen, G; Hu, K; Li, B; Li, J; Lyle, MP; Tang, L; Webster, J | 1 |
Alexander, HR; Blansfield, JA; Caragacianu, D; Libutti, SK; Lorang, D; Morita, SY; Muller, G; Royal, RE; Schafer, P; Stirling, D; Tangrea, MA | 1 |
Courtright, J; Houghton, PJ; Keir, ST; Kolb, EA; Lock, R; Maris, JM; Morton, CL; Reynolds, CP; Smith, MA; Tajbakhsh, M; Wu, J | 1 |
Anderson, WK | 1 |
Anderson, WK; McPherson, HL; New, JS; Rick, AC | 1 |
Anderson, WK; Chang, CP; Corey, PF; Halat, MJ; Jones, AN; McPherson, HL; New, JS; Rich, AC | 1 |
Higuchi, S; Saito, K; Sakamoto, Y; Yamaguchi, T; Yosida, S; Yuki, H | 1 |
App, H; Fong, TA; Hirth, KP; Kim, YH; McMahon, G; Powell, TJ; Risau, W; Schreck, R; Shawver, LK; Sun, L; Tang, C; Ullrich, A; Wang, X | 1 |
Arakawa, H; Kawamoto, H; Kojiri, K; Kondo, H; Morishima, H; Nishimura, I; Nishimura, S; Nishimura, T; Ohkubo, M; Suda, H; Tanaka, S; Yoshinari, T | 1 |
Andoh, T; Edatsugi, H; Ishizu, K; Kohno, H; Komatsu, H; Komi, A; Matsuba, Y; Matsunaga, A; Mita, I; Nakajima, Y; Nakanishi, O; Sato, S; Takezawa, K; Tsuruo, T; Yamazaki, K; Yamori, T | 1 |
Blake, RA; Fong, TA; Hawtin, R; Hirth, KP; Hubbard, SR; Laird, AD; Liang, C; McMahon, G; Mohammadi, M; Schlessinger, J; Shawver, LK; Shenoy, N; Strawn, LM; Sun, L; Tang, C; Tang, F; Thurnher, A; Ullrich, A; Vajkoczy, P | 1 |
Amishiro, N; Gomi, K; Kobayashi, E; Nagamura, S; Okabe, M; Okamoto, A; Saito, H | 1 |
Csernus, B; Halmos, G; Hebert, F; Nagy, A; Schally, AV; Sun, B; Szepeshazi, K | 1 |
Halmos, G; Nagy, A; Plonowski, A; Schally, AV; Sun, B | 1 |
Carver, J; Cherrington, JM; Christensen, JG; Laird, AD; Li, G; Louie, SG; Mendel, DB; Moss, KG; Smith, K; Xin, X | 1 |
Biaglow, JE; Chapman, JD; Durand, RE; Raleigh, JA; Rauth, AM; Reuvers, AP | 1 |
Cabral, JR; Mattocks, AR | 1 |
Sydor, A | 1 |
Herzfeld, A; Knox, WE; Mezl, VA | 1 |
Dominick, MA; McGuire, EJ; Sigler, RE | 1 |
Braune, M; Freyer, W; Lewald, T; Naether, D; Nowak, C; Roeder, B | 1 |
Pitot, HC; Weiss, JW | 1 |
Muzik, H; Paterson, AR; Warnick, CT | 1 |
Gitterman, CO | 1 |
Artico, M; Dolfini, E; Giuliano, R; Morasca, L; Porretta, GC; Scalzo, M; Vomero, S | 1 |
Balitskiĭ, KP; Struk, VI | 1 |
1 trial(s) available for pyrroles and Experimental Neoplasms
Article | Year |
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Enhancing the therapeutic responsiveness of photodynamic therapy with the antiangiogenic agents SU5416 and SU6668 in murine nasopharyngeal carcinoma models.
Topics: Adenocarcinoma; Angiogenesis Inhibitors; Animals; Anthracenes; Antineoplastic Agents; Chemotherapy, Adjuvant; Drug Screening Assays, Antitumor; Gene Expression; Indoles; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nasopharyngeal Neoplasms; Neoplasm Transplantation; Neoplasms, Experimental; Oxindoles; Perylene; Photochemotherapy; Propionates; Protein-Tyrosine Kinases; Proteins; Pyrroles; Survival Rate | 2005 |
100 other study(ies) available for pyrroles and Experimental Neoplasms
Article | Year |
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Design, synthesis and biological evaluation of 7-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-2,3-dihydro-1H-inden-1-one derivatives as potent FAK inhibitors for the treatment of ovarian cancer.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Female; Focal Adhesion Kinase 1; Humans; Indans; Mice; Mice, Inbred BALB C; Mice, Nude; Microsomes, Liver; Molecular Structure; Neoplasms, Experimental; Ovarian Neoplasms; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured | 2022 |
TGF-β receptor inhibitor LY2109761 enhances the radiosensitivity of gastric cancer by inactivating the TGF-β/SMAD4 signaling pathway.
Topics: Animals; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Male; Mice, Nude; Neoplasms, Experimental; Pyrazoles; Pyrroles; Radiation Tolerance; Signal Transduction; Smad4 Protein; Stomach Neoplasms; Transforming Growth Factor beta | 2019 |
MicroRNA-148b-colony-stimulating factor-1 signaling-induced tumor-associated macrophage infiltration promotes hepatocellular carcinoma metastasis.
Topics: Aminopyridines; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Macrophage Colony-Stimulating Factor; Macrophages; Male; Mice; Mice, Nude; MicroRNAs; Neoplasm Metastasis; Neoplasms, Experimental; Pyrroles; Signal Transduction | 2019 |
Injectable in Situ Forming Hydrogels of Thermosensitive Polypyrrole Nanoplatforms for Precisely Synergistic Photothermo-Chemotherapy.
Topics: Acrylic Resins; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Combined Modality Therapy; Delayed-Action Preparations; Doxorubicin; Drug Delivery Systems; Drug Liberation; Humans; Hydrogels; Hyperthermia, Induced; Infrared Rays; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Nanogels; Neoplasms, Experimental; NIH 3T3 Cells; Phase Transition; Phototherapy; Polymers; Pyrroles; Temperature; Xenograft Model Antitumor Assays | 2020 |
Amides of pyrrole- and thiophene-fused anthraquinone derivatives: A role of the heterocyclic core in antitumor properties.
Topics: Amides; Animals; Anthraquinones; Antineoplastic Agents; Apoptosis; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Heterocyclic Compounds; Humans; K562 Cells; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Docking Simulation; Molecular Structure; Neoplasms, Experimental; Pyrroles; Structure-Activity Relationship; Thiophenes | 2020 |
The Novel DPP-BDT Nanoparticles as Efficient Photoacoustic Imaging and Positron Emission Tomography Agents in Living Mice.
Topics: Animals; Contrast Media; Copper Radioisotopes; Female; Hep G2 Cells; Humans; Injections; Ketones; Mice; Mice, Nude; Multimodal Imaging; Nanoparticles; Neoplasms, Experimental; NIH 3T3 Cells; Phosphatidylethanolamines; Photoacoustic Techniques; Polyethylene Glycols; Polymers; Positron-Emission Tomography; Pyrroles; Radiopharmaceuticals; Xenograft Model Antitumor Assays | 2020 |
Molecular engineering of diketopyrrolopyrrole-conjugated polymer nanoparticles by chalcogenide variation for photoacoustic imaging guided photothermal therapy.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chalcogens; Drug Screening Assays, Antitumor; Humans; Ketones; Mice; Mice, Nude; Nanoparticles; Neoplasms, Experimental; Photoacoustic Techniques; Photothermal Therapy; Polymers; Pyrroles | 2021 |
A Highly Efficient One-for-All Nanodroplet for Ultrasound Imaging-Guided and Cavitation-Enhanced Photothermal Therapy.
Topics: Animals; Contrast Media; Female; Fluorocarbons; HeLa Cells; Humans; Mice, Inbred BALB C; Microbubbles; Nanostructures; Neoplasms; Neoplasms, Experimental; Phase Transition; Photoacoustic Techniques; Photothermal Therapy; Polymers; Pyrroles; Ultrasonography; Xenograft Model Antitumor Assays | 2021 |
A novel pyrrole-imidazole polyamide targets Aurora kinase A and suppresses tumor growth in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Aurora Kinase A; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Female; Humans; Imidazoles; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Nylons; Protein Kinase Inhibitors; Pyrroles; Tumor Cells, Cultured | 2021 |
Targeting of the breast cancer microenvironment with a potent and linkable oxindole based antiangiogenic small molecule.
Topics: Angiogenesis Inhibitors; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Mice; Mice, Inbred C57BL; Mice, SCID; Neoplasms, Experimental; Oxindoles; Pyrroles; Sunitinib; Tumor Burden; Tumor Microenvironment; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays | 2017 |
Quantification and tracking of genetically engineered dendritic cells for studying immunotherapy.
Topics: Animals; Biomedical Research; Brain Neoplasms; Cell Tracking; Dendritic Cells; Deoxycytidine; Drosophila melanogaster; Flow Cytometry; Genes, Insect; Genes, Reporter; Genetic Engineering; HEK293 Cells; Humans; Immunotherapy; Magnetic Resonance Imaging; Neoplasms, Experimental; Phosphotransferases (Alcohol Group Acceptor); Pyrroles | 2018 |
Efficient Cancer Regression by a Thermosensitive Liposome for Photoacoustic Imaging-Guided Photothermal/Chemo Combinatorial Therapy.
Topics: Animals; Hep G2 Cells; Humans; Hypothermia, Induced; Ketones; Liposomes; Mice; Neoplasms, Experimental; Photoacoustic Techniques; Phototherapy; Polyethylene Glycols; Pyrroles; Xenograft Model Antitumor Assays | 2017 |
Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer properties.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chick Embryo; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Neoplasms, Experimental; Pyrimidines; Pyrroles; Tubulin; Tubulin Modulators; Xenograft Model Antitumor Assays | 2017 |
Triphenylamine flanked furan-diketopyrrolopyrrole for multi-imaging guided photothermal/photodynamic cancer therapy.
Topics: Animals; Furans; HeLa Cells; Humans; Ketones; Mice; Nanoparticles; Neoplasms, Experimental; Photochemotherapy; Phototherapy; Pyrroles | 2017 |
pH Switchable Nanoassembly for Imaging a Broad Range of Malignant Tumors.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Cells, Cultured; Drug Screening Assays, Antitumor; HeLa Cells; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen-Ion Concentration; Ketones; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Neoplasms; Neoplasms, Experimental; Pyrroles; Thiophenes; Tumor Microenvironment | 2017 |
Near-infrared BODIPY-paclitaxel conjugates assembling organic nanoparticles for chemotherapy and bioimaging.
Topics: Animals; Antineoplastic Agents, Phytogenic; Boron Compounds; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Fluorescent Dyes; Halogenation; Humans; Infrared Rays; Mice; Mice, Inbred Strains; Nanoparticles; Neoplasms, Experimental; Optical Imaging; Paclitaxel; Particle Size; Pyrroles; Surface Properties; Tumor Cells, Cultured | 2018 |
Radiotherapy-Sensitized Tumor Photothermal Ablation Using γ-Polyglutamic Acid Nanogels Loaded with Polypyrrole.
Topics: Animals; Female; Gels; Mice; Mice, Inbred BALB C; Nanostructures; Neoplasms, Experimental; Photoacoustic Techniques; Photochemotherapy; Polyglutamic Acid; Polymerization; Polymers; Pyrroles; Radiotherapy; X-Rays; Xenograft Model Antitumor Assays | 2018 |
Targeted polypyrrole nanoparticles for the identification and treatment of hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Human Umbilical Vein Endothelial Cells; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Neoplasms, Experimental; Optical Imaging; Phototherapy; Polymers; Pyrroles; Theranostic Nanomedicine | 2018 |
Diketopyrrolopyrrole-based carbon dots for photodynamic therapy.
Topics: Animals; Carbon; Chitosan; Female; Hep G2 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Ketones; Mice; Neoplasms, Experimental; Photochemotherapy; Pyrroles; Quantum Dots; Xenograft Model Antitumor Assays | 2018 |
Enhanced Photoacoustic and Photothermal Effect of Functionalized Polypyrrole Nanoparticles for Near-Infrared Theranostic Treatment of Tumor.
Topics: Animals; HeLa Cells; Humans; Hyperthermia, Induced; Indocyanine Green; Indoles; Infrared Rays; Mice; Mice, Nude; Nanoparticles; Neoplasms, Experimental; Photoacoustic Techniques; Phototherapy; Polyethylene Glycols; Polymers; Pyrroles | 2019 |
The rasH2 mouse model for assessing carcinogenic potential of pharmaceuticals.
Topics: Animals; Body Weight; Carcinogenicity Tests; Cell Proliferation; Female; Genes, ras; Indoles; Male; Mice; Mice, Transgenic; Models, Animal; Neoplasms, Experimental; Pyrroles; Rats; Rats, Sprague-Dawley; Sunitinib | 2013 |
Accuracy of a clinical PET/CT vs. a preclinical μPET system for monitoring treatment effects in tumour xenografts.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Monitoring; Equipment Design; Equipment Failure Analysis; Female; Fluorodeoxyglucose F18; Indoles; Mice; Mice, Nude; Multimodal Imaging; Neoplasms, Experimental; Positron-Emission Tomography; Pyrroles; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Sunitinib; Tomography, X-Ray Computed; Treatment Outcome | 2013 |
Neem leaf glycoprotein is superior than cisplatin and sunitinib malate in restricting melanoma growth by normalization of tumor microenvironment.
Topics: Animals; Antineoplastic Agents; Azadirachta; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cisplatin; Cytokines; Female; Gene Expression Regulation, Neoplastic; Glycoproteins; Indoles; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Plant Leaves; Pyrroles; Sunitinib | 2013 |
Polypyrrole hollow microspheres as echogenic photothermal agent for ultrasound imaging guided tumor ablation.
Topics: Animals; Cell Line, Tumor; Contrast Media; Humans; Microspheres; Neoplasms, Experimental; Photosensitizing Agents; Phototherapy; Polymers; Pyrroles; Rabbits; Treatment Outcome; Ultrasonography, Interventional | 2013 |
Vessel size imaging (VSI) by robust magnetic resonance (MR) relaxometry: MR-VSI of solid tumors in correlation with immunohistology and intravital microscopy.
Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Dextrans; Female; Humans; Immunohistochemistry; Indoles; Magnetic Resonance Imaging; Magnetite Nanoparticles; Mice; Mice, Nude; Microscopy; Neoplasm Transplantation; Neoplasms, Experimental; Neovascularization, Pathologic; Pyrroles; Random Allocation; Sunitinib | 2013 |
Synergistic targeting of PI3K/AKT pathway and androgen receptor axis significantly delays castration-resistant prostate cancer progression in vivo.
Topics: Androgen Receptor Antagonists; Anilides; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Disease Progression; Drug Therapy, Combination; Humans; Male; Mice; Mice, Nude; Neoplasms, Experimental; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Prostatic Neoplasms, Castration-Resistant; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptors, Androgen; Signal Transduction; Tosyl Compounds; Xenograft Model Antitumor Assays | 2013 |
Identification of preferred chemotherapeutics for combining with a CHK1 inhibitor.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carbolines; Cell Cycle Checkpoints; Checkpoint Kinase 1; Dacarbazine; Deoxycytidine; DNA Damage; Gemcitabine; HCT116 Cells; High-Throughput Nucleotide Sequencing; HT29 Cells; Humans; Irinotecan; Mice; Mice, Nude; Neoplasms; Neoplasms, Experimental; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Pyrroles; Temozolomide; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2013 |
Engineering of perfluorooctylbromide polypyrrole nano-/microcapsules for simultaneous contrast enhanced ultrasound imaging and photothermal treatment of cancer.
Topics: Animals; Cells, Cultured; Female; Fluorocarbons; Humans; Hydrocarbons, Brominated; Hyperthermia, Induced; Mice; Mice, Inbred BALB C; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Neoplasms, Experimental; Particle Size; Phototherapy; Polymers; Pyrroles; Ultrasonography | 2014 |
A low molecular weight zinc2+-dipicolylamine-based probe detects apoptosis during tumour treatment better than an annexin V-based probe.
Topics: Amines; Angiogenesis Inhibitors; Animals; Annexin A5; Apoptosis; Carcinoma, Squamous Cell; Female; Fluorodeoxyglucose F18; Humans; Immunohistochemistry; Indoles; Mice; Mice, Nude; Molecular Probes; Molecular Weight; Neoplasms, Experimental; Organometallic Compounds; Picolinic Acids; Pyrroles; Skin Neoplasms; Sunitinib; Tumor Cells, Cultured; Zinc | 2014 |
Biodistribution of 99mTc-sunitinib as a potential radiotracer for tumor hypoxia imaging.
Topics: Animals; Cell Hypoxia; Indoles; Isotope Labeling; Mice; Neoplasms, Experimental; Organotechnetium Compounds; Pyrroles; Radiopharmaceuticals; Sunitinib; Tomography, Emission-Computed, Single-Photon | 2013 |
Xenograft tumors vascularized with murine blood vessels may overestimate the effect of anti-tumor drugs: a pilot study.
Topics: Animals; Blood Vessels; Cell Proliferation; Cisplatin; Endothelial Cells; Heterografts; Humans; Indoles; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Pilot Projects; Pyrroles; Signal Transduction; Species Specificity; Sunitinib; Tissue Engineering; Tumor Microenvironment | 2013 |
Drug-eluting beads loaded with antiangiogenic agents for chemoembolization: in vitro sunitinib loading and release and in vivo pharmacokinetics in an animal model.
Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cell Survival; Chemoembolization, Therapeutic; Delayed-Action Preparations; Drug-Eluting Stents; Indoles; Metabolic Clearance Rate; Microspheres; Neoplasms, Experimental; Organ Specificity; Pyrroles; Rabbits; Sunitinib; Tissue Distribution | 2014 |
A triple combination of atorvastatin, celecoxib and tipifarnib strongly inhibits pancreatic cancer cells and xenograft pancreatic tumors.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Atorvastatin; Celecoxib; Cell Line, Tumor; Cell Proliferation; Female; Heptanoic Acids; Humans; Injections, Intraperitoneal; Mice; Mice, SCID; Neoplasms, Experimental; Pancreatic Neoplasms; Pyrazoles; Pyrroles; Quinolones; Sulfonamides; Xenograft Model Antitumor Assays | 2014 |
The immunocytokine NHS-IL12 as a potential cancer therapeutic.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cancer Vaccines; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Docetaxel; Female; Humans; Immunoglobulin G; Immunomodulation; Indoles; Interferon-gamma; Interleukin-12; Lymphocyte Activation; Macaca fascicularis; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasms, Experimental; Protein Engineering; Pyrroles; Recombinant Fusion Proteins; Sunitinib; Survival Rate; Taxoids; Tumor Burden | 2014 |
Synthesis and in vivo SAR study of indolin-2-one-based multi-targeted inhibitors as potential anticancer agents.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Indoles; Mice; Molecular Structure; Neoplasms, Experimental; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Structure-Activity Relationship; Sunitinib | 2014 |
Sunitinib combined with angiotensin-2 type-1 receptor antagonists induces more necrosis: a murine xenograft model of renal cell carcinoma.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Benzoates; Carcinoma, Renal Cell; Female; Humans; Indoles; Kidney Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Pyrroles; Sunitinib; Telmisartan; Xenograft Model Antitumor Assays | 2014 |
Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Janus Kinase 2; Mice; Mice, SCID; Models, Molecular; Molecular Structure; Neoplasms, Experimental; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Structure-Activity Relationship; Substrate Specificity | 2014 |
Immune consequences of decreasing tumor vasculature with antiangiogenic tyrosine kinase inhibitors in combination with therapeutic vaccines.
Topics: Angiogenesis Inhibitors; Animals; Cancer Vaccines; Cell Line, Tumor; Combined Modality Therapy; Female; Flow Cytometry; Humans; Indoles; Lymphocytes, Tumor-Infiltrating; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Experimental; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Sorafenib; Sunitinib; Vaccines, Synthetic | 2014 |
Modulation by licofelone and celecoxib of experimentally induced cancer and preneoplastic lesions in mice exposed to cigarette smoke.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Body Weight; Celecoxib; Cyclooxygenase 2 Inhibitors; Enzyme Inhibitors; Female; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Precancerous Conditions; Pyrroles; Smoking; Survival Rate; Toxicity Tests, Subchronic | 2015 |
VEGFR2-Targeted Contrast-Enhanced Ultrasound to Distinguish between Two Anti-Angiogenic Treatments.
Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cell Survival; Contrast Media; Drug Monitoring; Female; Imatinib Mesylate; Indoles; Mice; Mice, Inbred BALB C; Molecular Imaging; Neoplasms, Experimental; Pyrroles; Reproducibility of Results; Sensitivity and Specificity; Sunitinib; Treatment Outcome; Ultrasonography; Vascular Endothelial Growth Factor Receptor-2 | 2015 |
[Impact of VEGF-A in exhaustion of intratumoral T cells].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; CD8-Positive T-Lymphocytes; Gene Expression Regulation, Neoplastic; Humans; Indoles; Lymphocytes, Tumor-Infiltrating; Molecular Targeted Therapy; Neoplasm Proteins; Neoplasms, Experimental; Programmed Cell Death 1 Receptor; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Sunitinib; T-Lymphocytes, Cytotoxic; Vascular Endothelial Growth Factor A | 2015 |
Synergistic Effect of Anti-Angiogenic and Radiation Therapy: Quantitative Evaluation with Dynamic Contrast Enhanced MR Imaging.
Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Combined Modality Therapy; Contrast Media; Gadolinium DTPA; Humans; Indoles; Lung Neoplasms; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Mice, Nude; Muscle, Skeletal; Neoplasms, Experimental; Pyrroles; Random Allocation; Sunitinib; Thigh; Transplantation, Heterotopic; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Imidazoles; Mice; Mice, Nude; Molecular Structure; Neoplasms, Experimental; NIH 3T3 Cells; Protein Kinase Inhibitors; Pyrazines; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2016 |
Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Humans; Mice; Models, Molecular; Molecular Structure; Neoplasms, Experimental; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-pim-1; Pyrroles; Quinazolinones; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2016 |
Synthesis of Novel c(AmpRGD)-Sunitinib Dual Conjugates as Molecular Tools Targeting the α
Topics: Angiogenesis Inhibitors; Animals; Cell Line; Humans; Indoles; Integrin alphaVbeta3; Mice; Neoplasms, Experimental; Neovascularization, Pathologic; Oligopeptides; Pyrroles; Sunitinib; Vascular Endothelial Growth Factor Receptor-2 | 2017 |
Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Cell Differentiation; Cell Line, Tumor; Disease Progression; Female; Isoquinolines; Kaplan-Meier Estimate; Killer Cells, Natural; Male; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Mice, Transgenic; Neoplasms, Experimental; Pyridines; Pyrroles; RNA Interference; Smad3 Protein | 2017 |
TrkA kinase inhibitors from a library of modified and isosteric Staurosporine aglycone.
Topics: Animals; Antineoplastic Agents; Carbazoles; Male; Molecular Conformation; Neoplasms, Experimental; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor, trkA; Small Molecule Libraries; Staurosporine; Stereoisomerism; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2008 |
Antitumor and apoptosis promoting properties of atorvastatin, an inhibitor of HMG-CoA reductase, against Dalton's Lymphoma Ascites tumor in mice.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Atorvastatin; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Peroxidation; Male; Mice; Models, Chemical; Neoplasms, Experimental; Pyrroles; Reactive Oxygen Species | 2008 |
Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models.
Topics: Animals; Atorvastatin; Benzenesulfonates; Cystadenoma; Disease Models, Animal; Doxycycline; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Heptanoic Acids; Immunosuppressive Agents; Interferon-gamma; Kidney Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Neoplasms, Experimental; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pyridines; Pyrroles; Sirolimus; Sorafenib; Survival Analysis; Treatment Outcome; Tuberous Sclerosis; Tuberous Sclerosis Complex 2 Protein; Tumor Burden; Tumor Suppressor Proteins | 2009 |
Effects of antalarmin and nadolol on the relationship between social stress and pulmonary metastasis development in male OF1 mice.
Topics: Adrenergic beta-Antagonists; Aggression; Animals; Central Nervous System Agents; Corticosterone; Interferon-gamma; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Nadolol; Neoplasms, Experimental; Pyrimidines; Pyrroles; Random Allocation; Receptors, Corticotropin-Releasing Hormone; Social Behavior; Stress, Psychological | 2009 |
Sunitinib improves chemotherapeutic efficacy and ameliorates cisplatin-induced nephrotoxicity in experimental animals.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antioxidants; Body Weight; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Cisplatin; Drug Synergism; Female; Indoles; Kidney; Male; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Organ Size; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Sunitinib; Tumor Burden; Vascular Endothelial Growth Factor A | 2011 |
HGF/c-Met acts as an alternative angiogenic pathway in sunitinib-resistant tumors.
Topics: Angiogenesis Inhibitors; Animals; Drug Resistance, Neoplasm; Hepatocyte Growth Factor; Humans; Indoles; Mice; Mice, Nude; Neoplasms, Experimental; Neovascularization, Pathologic; NIH 3T3 Cells; Proto-Oncogene Proteins c-met; Pyrroles; Signal Transduction; Sunitinib; Transfection | 2010 |
Effect of sunitinib combined with ionizing radiation on endothelial cells.
Topics: Animals; Cell Line, Tumor; Cell Survival; Cells, Cultured; Combined Modality Therapy; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Endothelial Cells; Humans; Indoles; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Pyrroles; Radiation Tolerance; Radiation-Sensitizing Agents; Radiation, Ionizing; Sunitinib; Treatment Outcome | 2011 |
Consequence of dose scheduling of sunitinib on host immune response elements and vaccine combination therapy.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cancer Vaccines; Carcinoembryonic Antigen; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Flow Cytometry; Humans; Immune System; Indoles; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Experimental; Pyrroles; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Sunitinib; T-Lymphocytes, Regulatory; Treatment Outcome | 2012 |
Atorvastatin modulates anti-proliferative and pro-proliferative signals in Her2/neu-positive mammary cancer.
Topics: Animals; Antineoplastic Agents; Atorvastatin; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Heptanoic Acids; Hypolipidemic Agents; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 6; Neoplasms, Experimental; NF-kappa B; Pyrroles; ras Proteins; Receptor, ErbB-2; rhoA GTP-Binding Protein; Terpenes | 2011 |
Sunitinib inhibits tumor vascularity and growth but does not affect Akt and ERK phosphorylation in xenograft tumors.
Topics: Angiogenesis Inhibitors; Angiogenic Proteins; Animals; Cell Growth Processes; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Female; HEK293 Cells; Humans; Indoles; Mice; Mice, Inbred NOD; Mice, SCID; Microvessels; Neoplasms, Experimental; Neovascularization, Pathologic; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrroles; Random Allocation; Sunitinib; Xenograft Model Antitumor Assays | 2011 |
Investigations regarding the utility of prodigiosenes to treat leukemia.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Leukemia; Molecular Structure; Neoplasms, Experimental; Prodigiosin; Pyrroles; Structure-Activity Relationship; Zebrafish | 2013 |
Uniform polypyrrole nanoparticles with high photothermal conversion efficiency for photothermal ablation of cancer cells.
Topics: HeLa Cells; Humans; Hyperthermia, Induced; Materials Testing; Nanoparticles; Neoplasms, Experimental; Photosensitizing Agents; Phototherapy; Polymers; Pyrroles; Treatment Outcome | 2013 |
Dose-dependent response of tumor vasculature to radiation therapy in combination with Sunitinib depicted by three-dimensional high-frequency power Doppler ultrasound.
Topics: Angiogenesis Inhibitors; Animals; Dose-Response Relationship, Drug; Immunohistochemistry; Indoles; Mice; Neoplasms, Experimental; Pyrroles; Sunitinib; Ultrasonography, Doppler | 2013 |
Blockade of epidermal growth factor receptor signaling on tumor cells and tumor-associated endothelial cells for therapy of human carcinomas.
Topics: Animals; Antineoplastic Agents; Deoxycytidine; Endothelium, Vascular; ErbB Receptors; Gemcitabine; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Neovascularization, Pathologic; Paclitaxel; Pyrimidines; Pyrroles; Signal Transduction; Tumor Cells, Cultured | 2002 |
Pharmacodynamic-mediated effects of the angiogenesis inhibitor SU5416 on the tumor disposition of temozolomide in subcutaneous and intracerebral glioma xenograft models.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Dacarbazine; Disease Models, Animal; Drug Interactions; Glioma; Indoles; Neoplasm Transplantation; Neoplasms, Experimental; Pyrroles; Rats; Rats, Nude; Receptors, Vascular Endothelial Growth Factor; Temozolomide; Tumor Cells, Cultured | 2003 |
SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models.
Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Lewis Lung; Combined Modality Therapy; Endothelium, Vascular; Glioblastoma; Humans; Indoles; Mice; Mice, Inbred C57BL; Neoplasm Recurrence, Local; Neoplasms, Experimental; Neovascularization, Pathologic; Pyrroles; Receptor Protein-Tyrosine Kinases; Sunitinib | 2003 |
Importance of vascular endothelial growth factor A in the progression of experimental neuroblastoma.
Topics: Angiogenesis Inhibitors; Animals; Cell Division; Endothelial Growth Factors; Female; Humans; Indoles; Male; Mice; Mice, Nude; Neoplasms, Experimental; Neuroblastoma; Protein-Tyrosine Kinases; Pyrroles; Transplantation, Heterologous; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2002 |
[Studies on a combined effect of the antibiotic 6270 and certain synthetic preparations with antineoplastic action on the growth of experimental tumors].
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antineoplastic Agents; Neoplasms, Experimental; Pyrroles | 1961 |
[ADDITIONAL CLASSES OF COMPOUNDS INHIBITING TUMORS. I. CYTOSTATIC EFFECTS OF N- AND S-HYDROXYMETHYL COMPOUNDS].
Topics: Amides; Animals; Antineoplastic Agents; Benzimidazoles; Carbohydrate Metabolism; Carcinoma, Ehrlich Tumor; Cytostatic Agents; Formaldehyde; Hydantoins; Imidazoles; Isonicotinic Acids; Mice; Morpholines; Neoplasms, Experimental; Niacin; Niacinamide; Piperazines; Piperidines; Pyrroles; Research; Urea | 1963 |
THE HUMAN TUMOR-EGG HOST SYSTEM. III. TUMOR-INHIBITORY PROPERTIES OF TENUAZONIE ACID.
Topics: Adenocarcinoma; Antineoplastic Agents; Aspergillus; Azaserine; Carcinoma, Bronchogenic; Chick Embryo; Glycine; Mercaptopurine; Neoplasms; Neoplasms, Experimental; Puromycin; Pyrroles; Research; Saccharomyces; Tissue Culture Techniques; Triethylenemelamine | 1964 |
[Studies on the effect of 6 alkaloids related to 1-methylpyrrolizidine on the growth of hepatoma and of certain other transplanted tumors in animals].
Topics: Alkaloids; Animals; Carcinoma, Hepatocellular; Liver Neoplasms; Liver Neoplasms, Experimental; Neoplasm Transplantation; Neoplasms, Experimental; Pyrroles | 1959 |
Development of a syngeneic in vivo tumor model and its use in evaluating a novel P-glycoprotein modulator, PGP-4008.
Topics: Acetanilides; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Line, Transformed; Disease Models, Animal; Drug Resistance, Multiple; Humans; Mice; Neoplasms, Experimental; Pyrroles; Quinolines | 2003 |
Growth inhibition of experimental non-Hodgkin's lymphomas with the targeted cytotoxic somatostatin analogue AN-238.
Topics: Animals; Antineoplastic Agents; Body Weight; Doxorubicin; Humans; Kinetics; Leukocytes; Lymphoma, Non-Hodgkin; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Peptides; Pyrroles; Receptors, Somatostatin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatostatin; Time Factors | 2005 |
Angiogenesis inhibitor Z24 induces endothelial cell apoptosis and suppresses tumor growth and metastasis.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Line; Cell Line, Tumor; Colonic Neoplasms; Endothelium, Vascular; Humans; Lung Neoplasms; Male; Mesylates; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Neovascularization, Pathologic; Pyrroles; Transplantation, Heterologous | 2005 |
Medicinal chemistry approaches to target the kinase activity of IGF-1R.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Benzimidazoles; Drug Evaluation, Preclinical; Humans; Neoplasms, Experimental; Podophyllotoxin; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Pyridones; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Signal Transduction; Tyrphostins | 2006 |
[Effect of angiogenesis inhibitor SU6668 on the growth and metastasis of gastric cancer in SCID mice].
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Line, Tumor; Drug Synergism; Fluorouracil; Humans; Indoles; Liver Neoplasms; Male; Mice; Mice, SCID; Neoplasm Transplantation; Neoplasms, Experimental; Neovascularization, Pathologic; Oxindoles; Propionates; Pyrroles; Stomach Neoplasms | 2006 |
Preclinical pharmacology of the pyrrolobenzodiazepine (PBD) monomer DRH-417 (NSC 709119).
Topics: Animals; Anthramycin; Antibiotics, Antineoplastic; Benzodiazepines; Cell Proliferation; Chromatography, High Pressure Liquid; Gene Expression Profiling; Humans; Mass Spectrometry; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Pyrroles; Transplantation, Heterologous | 2007 |
Pathological animal models in the experimental evaluation of tumour microvasculature with magnetic resonance imaging.
Topics: Adenocarcinoma; Albumins; Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Hormonal; Colonic Neoplasms; Contrast Media; Gadolinium DTPA; Indoles; Magnetic Resonance Imaging; Mammary Neoplasms, Experimental; Microcirculation; Neoplasms, Experimental; Organometallic Compounds; Oxindoles; Propionates; Protein-Tyrosine Kinases; Pyrroles; Rats; Tamoxifen | 2007 |
Substituted 6-amino-4H-[1,2]dithiolo[4,3-b]pyrrol-5-ones: synthesis, structure-activity relationships, and cytotoxic activity on selected human cancer cell lines.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Female; Heterocyclic Compounds, 2-Ring; Male; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Pyrroles; Structure-Activity Relationship | 2007 |
Combining agents that target the tumor microenvironment improves the efficacy of anticancer therapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Cyclophosphamide; Endothelial Cells; Female; Fluorescent Antibody Technique; Humans; Indoles; Lenalidomide; Mice; Neoplasms, Experimental; Neovascularization, Pathologic; Pyrroles; Rats; Sunitinib; Thalidomide; Xenograft Model Antitumor Assays | 2008 |
Initial testing (stage 1) of sunitinib by the pediatric preclinical testing program.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Child; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Indoles; Mice; Neoplasms, Experimental; Pyrroles; Sunitinib; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays | 2008 |
Activity of bis-carbamoyloxymethyl derivatives of pyrroles and pyrrolizines against human tumor xenografts in nude mice.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Carcinoma, Small Cell; Cell Line; Colonic Neoplasms; Drug Evaluation, Preclinical; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Pyrroles; Pyrrolidines; Transplantation, Heterologous | 1982 |
Synthesis and murine antineoplastic activity of bis[(carbamoyloxy)methyl] derivatives of pyrrolo[2,1-a]isoquinoline.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carbamates; Chemical Phenomena; Chemistry; Isoquinolines; Leukemia P388; Magnetic Resonance Spectroscopy; Mice; Neoplasms, Experimental; Pyrroles; Spectrophotometry, Infrared; Structure-Activity Relationship; Transplantation, Heterologous | 1984 |
Vinylogous carbinolamine tumor inhibitors. 8. Activity of bis(acyloxymethyl) derivatives of pyrroles and pyrrolizines against a panel of murine leukemias and solid tumors.
Topics: Animals; Drug Evaluation, Preclinical; Leukemia, Experimental; Male; Mice; Neoplasms, Experimental; Pyrroles; Pyrrolidines; Structure-Activity Relationship | 1982 |
[Studies on tenuazonic acid analogs. IV. Preparation of condensation products of 3-acetyltetramanilide with substituted benzaldehydes and their antitumor activities (author's transl)].
Topics: Animals; Antibiotics, Antineoplastic; Benzaldehydes; Chemical Phenomena; Chemistry, Physical; Mice; Neoplasms, Experimental; Pyrroles; Tenuazonic Acid | 1981 |
SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.
Topics: 3T3 Cells; Animals; Catalysis; Cell Division; Endothelium, Vascular; Enzyme Inhibitors; Glioma; Humans; Indoles; Mice; Neoplasms, Experimental; Neovascularization, Pathologic; Protein-Tyrosine Kinases; Pyrroles; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Mitogen; Receptors, Vascular Endothelial Growth Factor; Tumor Cells, Cultured | 1999 |
Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506.
Topics: Animals; Antineoplastic Agents; Carbazoles; DNA Topoisomerases, Type I; Enzyme Inhibitors; Glucosides; Humans; Indoles; Inhibitory Concentration 50; Kinetics; Mice; Models, Chemical; Neoplasms, Experimental; Pyrroles; Topoisomerase I Inhibitors; Tumor Cells, Cultured | 1999 |
Potent antitumor activity of MS-247, a novel DNA minor groove binder, evaluated by an in vitro and in vivo human cancer cell line panel.
Topics: Animals; Antineoplastic Agents, Alkylating; Benzimidazoles; DNA-Binding Proteins; DNA, Neoplasm; Drug Screening Assays, Antitumor; Humans; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Pyrroles; Transplantation, Heterologous; Tumor Cells, Cultured | 1999 |
SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.
Topics: 3T3 Cells; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Division; Crystallography, X-Ray; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Indoles; Kinetics; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Molecular; Neoplasm Transplantation; Neoplasms, Experimental; Neovascularization, Pathologic; Oxindoles; Propionates; Protein-Tyrosine Kinases; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Receptors, Fibroblast Growth Factor; Receptors, Growth Factor; Receptors, Mitogen; Receptors, Vascular Endothelial Growth Factor; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Synthesis and antitumor activity of duocarmycin derivatives: A-ring pyrrole compounds bearing beta-(5',6',7'-trimethoxy-2'-indolyl)acryloyl group.
Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Duocarmycins; HeLa Cells; Humans; Indoles; Inhibitory Concentration 50; Leukocyte Count; Male; Mice; Neoplasms, Experimental; Platelet Count; Pyrroles; Pyrrolidinones; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Targeting of cytotoxic somatostatin analog AN-238 to somatostatin receptor subtypes 5 and/or 3 in experimental pancreatic cancers.
Topics: Animals; Antibiotics, Antineoplastic; Binding, Competitive; Cell Division; Doxorubicin; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Nude; Neoplasms, Experimental; Pancreatic Neoplasms; Pyrroles; Receptors, Somatostatin; RNA, Messenger; Survival Analysis; Time Factors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2001 |
Effective treatment of experimental DU-145 prostate cancers with targeted cytotoxic somatostatin analog AN-238.
Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Cytotoxins; Doxorubicin; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Octreotide; Prostatic Neoplasms; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Treatment Outcome; Tumor Cells, Cultured | 2002 |
SU6668 inhibits Flk-1/KDR and PDGFRbeta in vivo, resulting in rapid apoptosis of tumor vasculature and tumor regression in mice.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Blood Vessels; Cell Division; Dose-Response Relationship, Drug; Humans; Indoles; Kinetics; Mice; Mice, Nude; Neoplasms, Experimental; Oxindoles; Propionates; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2002 |
Nitropyrrole radiosensitizers: structure function relationships.
Topics: Animals; Cell Survival; In Vitro Techniques; Mice; Neoplasms, Experimental; Oxygen Consumption; Pyrroles; Radiation-Sensitizing Agents; Structure-Activity Relationship | 1978 |
Effects of some pyrrolic and dihydropyrrolizine esters on mouse skin: a preliminary study.
Topics: Alkylating Agents; Animals; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Pyrroles; Pyrrolizidine Alkaloids; Skin Neoplasms; Structure-Activity Relationship | 1979 |
[Effect of a synthetic derivative of verrucarine E and endoxan Guerin's tumor in rats].
Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Cyclophosphamide; Male; Neoplasms, Experimental; Pyrroles; Rats; Syndrome | 1975 |
Enzymes metabolizing delta1-pyrroline-5-carboxylate in rat tissues.
Topics: Animals; Fetus; Neoplasms, Experimental; Oxidoreductases; Proline; Pyrroles; Pyrroline Carboxylate Reductases; Rats; Stereoisomerism; Temperature | 1977 |
Subacute toxicity of a halogenated pyrrole hydroxymethylglutaryl-coenzyme A reductase inhibitor in Wistar rats.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Keratosis; Liver; Male; Mevalonic Acid; Necrosis; Neoplasms, Experimental; Organ Size; Pyrroles; Rats; Rats, Wistar; Stomach; Stomach Diseases | 1992 |
Photophysical properties and photodynamic activity in vivo of some tetrapyrroles.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Female; Fluorescence; Luminescent Measurements; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Metastasis; Neoplasms, Experimental; Photochemistry; Photochemotherapy; Pyrroles; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1990 |
Inhibition of ribosomal RNA maturation in Novikoff hepatoma cells by toyocamycin, tubercidin, and 6-thioguanosine.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Carcinoma, Hepatocellular; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Guanosine; Liver Neoplasms; Mercaptopurine; Methionine; Neoplasms, Experimental; Nitriles; Pyrimidines; Pyrroles; Ribonucleosides; RNA, Neoplasm; RNA, Ribosomal; Tritium; Uridine | 1974 |
Interference with nucleoside transport in mouse lymphoma cells proliferating in culture.
Topics: Adenosine; Animals; Ascitic Fluid; Aza Compounds; Biological Transport; Bromodeoxyuridine; Carbon Isotopes; Cell Division; Cell-Free System; Cells, Cultured; Guanosine; Inosine; Lymphoma; Male; Mercaptopurine; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Pyrazoles; Pyrimidinones; Pyrroles; Ribonucleosides; Thymidine; Time Factors; Transplantation, Homologous | 1972 |
Antitumor, cytotoxic, and antibacterial activities of tenuazonic acid and congeneric tetramic acids.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Bacillus megaterium; Chemistry, Pharmaceutical; Chick Embryo; Culture Techniques; Neoplasms, Experimental; Pyrroles | 1965 |
[Research on compounds with antineoplastic activity. 47. 1-(2,5-Dimethoxyphenyl)pyrrole derivatives: synthesis and cytostatic activity].
Topics: Aldehydes; Antineoplastic Agents; Carboxylic Acids; Culture Media; Magnetic Resonance Spectroscopy; Neoplasms, Experimental; Pyrroles; Spectrophotometry, Infrared; Structure-Activity Relationship | 1972 |
[Activation of protective reactions of the organism in malignant growths].
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Benzimidazoles; Drug Synergism; Immunity, Active; Neoplasms, Experimental; Parasympatholytics; Pigments, Biological; Prodigiosin; Pyrroles; Rabbits; Rats; Zymosan | 1968 |