Compounds > pyrroles
Page last updated: 2024-08-18

pyrroles and Edema

pyrroles has been researched along with Edema in 77 studies

Research

Studies (77)

TimeframeStudies, this research(%)All Research%
pre-199023 (29.87)18.7374
1990's10 (12.99)18.2507
2000's20 (25.97)29.6817
2010's22 (28.57)24.3611
2020's2 (2.60)2.80

Authors

AuthorsStudies
Padrón-Pérez, N1
Chamorro-Cevallos, GA; Cristobal-Luna, JM; Delgado, F; Escalante, CH; Esquivel-Campos, AL; Gómez-García, O; Gutiérrez-Rebolledo, GA; Hernández-Benitez, RI; Madrigal, DA; Pérez-Gutiérrez, S; Tamariz, J1
Abdalla, AN; Abourehab, MAS; Ahmed, M; Aslam, A; Attalah, KM; ElSawy, NA; Gouda, AM1
Kishibuchi, M; Takada, K; Yoshioka, K1
Bijev, AT; Kostadinov, I; Vladimirova, S; Zlatanova, H1
Adashek, JJ; Bergerot, PG; Boyd, T; Carret, AS; Chhabra, S; Forero-Torres, A; Gartner, EM; Hoimes, CJ; Li, H; Morris, JC; Pal, SK; Smith, DC; Thompson, JA; Vogelzang, NJ; Yu, X1
Delev, D; Deneva, T; Kostadinov, I; Kostadinova, I; Vladimirova, S; Zlatanova, H1
Almon, RR; DuBois, DC; Jusko, WJ; Song, D; Yu, R1
Beuselinck, B; Claus, F; Cornelissen, L; De Keyzer, F; Dumez, H; Lerut, E; Van Poppel, H; Wolter, P1
Gkermani, A; Hadjipavlou-Litina, D; Konstantinidou, M1
Anzini, M; Biava, M; Brindisi, M; Brogi, S; Cappelli, A; Di Capua, A; Di Cesare Mannelli, L; Ghelardini, C; Giordani, A; Giorgi, G; Pace, S; Poce, G; Rossi, A; Sautebin, L; Sticozzi, C; Valacchi, G1
Bowes, MA; Bradley, JD; Conaghan, PG; Fuerst, T; Hrycaj, P; Irazoque-Palazuelos, F; Soma, K; Soto-Raices, O; van der Heijde, D; Wilkinson, B; Wu, C; Wyman, BT; Xie, Z; Zhang, R; Østergaard, M1
Ahmad, A; Choudhary, D; Hasan, SM; Husain, A; Khan, SA; Khokra, SL1
Deng, J; Liang, AL; Tang, J; Wang, DX; Xiang, DK1
Anzellotti, P; Anzini, M; Biava, M; Botta, M; Cappelli, A; Ghelardini, C; Giordani, A; Makovec, F; Manetti, F; Norcini, M; Patrignani, P; Pergola, C; Rossi, A; Rovini, M; Sautebin, L; Vomero, S1
Anzellotti, P; Anzini, M; Biava, M; Botta, M; Cirilli, R; Ferretti, R; Forli, S; Gallinella, B; Ghelardini, C; Giordani, A; La Torre, F; Makovec, F; Manetti, F; Norcini, M; Patrignani, P; Pergola, C; Poce, G; Porretta, GC; Rossi, A; Sautebin, L; Supino, S1
Alam, MM; Anwer, T; Hasan, SM; Husain, A1
Chu, F; Feng, Z; Guo, Z; Sun, P1
Abbas, SE; Awadallah, FM; Gouda, AM; Ibrahim, NA1
Ahire, YS; Dandawate, PR; Gandhi, SP; Ghaisas, MM; Zawar, SA1
Barsoum, FF1
Bensdorf, K; Guo, C; Gust, R; Huang, W; Liu, H; Liu, W; Qian, H; Rubner, G; Wang, Y; Wellner, A; Zhang, H; Zhang, Y; Zhou, J1
Berlin, JD; Calcutt, MW; Chen, AP; Hachey, DL; Hartley, JA; Lee, W; Liao, CY; Puzanov, I; Rothenberg, ML; Spanswick, VJ; Vermeulen, WL1
Georgikopoulou, K; Hadjipavlou-Litina, D; Mavromoustakos, T; Michas, G; Moutevelis-Minakakis, P; Neophytou, N; Papavassilopoulou, E; Ragoussi, ME; Zoumpoulakis, P1
Fatahala, SS; Kamel, R; Mohamed, MS1
Baiuomy, AR; Elmegeed, GA; Eskander, EF; Mohareb, RM; William, MG1
Alfonso, S; Anzellotti, P; Anzini, M; Battilocchio, C; Biava, M; Bruno, A; Calderone, V; Di Cesare Mannelli, L; Ghelardini, C; Giordani, A; Giorgi, G; Martelli, A; Papa, G; Patrignani, P; Poce, G; Porretta, GC; Rossi, A; Rovini, M; Sautebin, L; Testai, L; Valenti, S1
Balagué, C; Godessart, N; Pont, M; Prats, N1
Blei, AT; Blendis, LM; Thuluvath, PJ; Wong, F1
Yang, Z; Zhang, SF; Zhao, LQ1
Goud, PS; Hegde, P; Kumar, MP; Kumar, PR; Raju, S; Reddy, GO; Reddy, VV; Sailaja, M; Sarma, MR; Suresh, T1
Bai, AP; Bai, JY; Chen, XH; Cheng, GF; Guo, ZR; Shen, F1
Barraclough, D; Colman, PG; Reed, MD1
Bijev, A; Bocheva, A; Lessigiarska, I; Nankov, A; Pajeva, I1
Barsante, MM; Castro, MS; Pinho, V; Roffê, E; Souza, DG; Tafuri, WL; Teixeira, MM; Yokoro, CM1
Kulkarni, SK; Patil, CS; Singh, VP1
Beeram, M; Berg, K; de Bono, JS; Eckhart, SG; Forero, L; Hammond, LA; Izbicka, E; Mita, AC; Mita, MM; Patnaik, A; Rowinsky, EK; Simmons, P; Takimoto, C; Tolcher, AW; Weiss, GR1
Bijev, A; Bocheva, A; Stoev, G; Yaneva, D1
Daidone, G; Harrak, Y; Plescia, S; Pujol, MD; Rosell, G; Schillaci, D1
Anzellotti, P; Anzini, M; Biava, M; Botta, M; Cappelli, A; Forli, S; Ghelardini, C; Makovec, F; Manetti, F; Patrignani, P; Pergola, C; Poce, G; Porretta, GC; Rossi, A; Rovini, M; Sautebin, L; Supino, S; Vivoli, E1
Wang, F; Wang, J; Zhang, S1
Andalib, S; Garjani, A; Maleki-Dizaji, N; Ziaee, M1
Artico, M; Corelli, F; Fanini, D; Giorgi, G; Massa, S; Palumbo, G; Pantaleoni, GC; Stefancich, G1
Burdisso, M; Leali, M; Panzone, G; Schiatti, P; Selva, D; Tarzia, G1
Ishii, K; Motoyoshi, S; Nakamura, H; Seto, Y; Shimizu, M; Yokoyama, Y1
Cenarruzabeitia, E; Fontan, JL; Lasheras, B1
Imazu, C; Ishii, K; Motoyoshi, S; Nakamura, H; Seto, Y; Shimizu, M; Yokoyama, Y1
Maloney, PJ; Rooks, WH; Schuler, ME; Tomolonis, AJ; Wallach, MB1
Kadokawa, T; Motoyoshi, S; Nakamura, H; Seto, Y; Shimizu, M; Yokoyama, Y1
Brain, SD; Gupta, P; Kajekar, R; Shepperson, NB1
Demopoulos, VJ; Rekka, E1
Albrecht, W; Algate, DR; Atterson, PR; Augustin, J; Elsässer, R; Guserle, R; Laufer, S; Munt, PL; Tries, S1
Augustin, J; Dannhardt, G; Laufer, S; Tries, S1
Chiu, HF; Lee, SG; Lin, CC; Lin, JM; Yang, JJ1
Morimoto, Y; Oda, M; Yamamoto, N; Yamashita, A; Yokota, K1
Gardner, DR; James, LF; Molyneux, RJ; Stegelmeier, BL1
Collins, PW; Currie, JL; Isakson, PC; Khanna, IK; Koboldt, CM; Miyashiro, JM; Seibert, K; Veenhuizen, AW; Weier, RM; Yu, Y1
Alcaraz, MJ; Gonzalez-Tejero, A; Molina, P; Rioja, I; Tárraga, A; Terencio, MC; Ubeda, A1
Laufer, S; Neupert, W; Tries, S1
Boyle, E; Freeman, PC; Goudie, AC; Mangan, FR; Thomson, M1
Ishii, K; Motoyoshi, S; Nakamura, H; Shimizu, M; Yokoyama, Y1
Panzone, G; Schiatti, P; Selva, D; Tarzia, G1
Rainsford, KD; Whitehouse, MW1
Carminati, P; Panzone, G; Schiatti, P; Selva, D; Tarzia, G1
Carty, TJ; Moore, PF; Mylari, BL; Zembrowski, WJ1
Arrigoni-Martelli, E1
Ackerman, N; Ballaron, SA; Galeazzi, E; Greenhouse, R; Guzmán, A; Muchowski, JM; Peréz, V; Rovito, JR; Tomolonis, AJ; Young, JM1
Cenarruzabeitia, E; Lasheras, B; Ucelay, M1
Auzzi, G; Bruni, F; Costanzo, A; Longo, G; Matucci, M; Messori, A; Pecori Vettori, L; Perretti, F; Pirisino, R1
Ackrell, J; Cheung, P; Cook, J; Cooper, GF; Gallegra, P; Halpern, O; Kluge, AF; Koehler, R; Muchowski, JM; Unger, SH1
Gardocki, JF; Pruss, TP; Wong, S1
Carson, JR; Wong, S1
Bauer, VJ; Safir, SR1
Iizuka, Y; Tanaka, K1
Iizuka, Y; Matsuda, K; Tanaka, K1
Iizuka, Y; Masuda, H; Tanaka, K; Tomita, K; Yoshida, N1
Carson, JR; McKinstry, DN; Wong, S1

Trials

5 trial(s) available for pyrroles and Edema

ArticleYear
A phase 1 trial of SGN-CD70A in patients with CD70-positive, metastatic renal cell carcinoma.
    Cancer, 2019, 04-01, Volume: 125, Issue:7

    Topics: Aged; Anemia; Benzodiazepines; Carcinoma, Renal Cell; CD27 Ligand; Edema; Fatigue; Female; Humans; Immunoconjugates; Kidney Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Pyrroles; Thrombocytopenia

2019
Comparing the effects of tofacitinib, methotrexate and the combination, on bone marrow oedema, synovitis and bone erosion in methotrexate-naive, early active rheumatoid arthritis: results of an exploratory randomised MRI study incorporating semiquantitati
    Annals of the rheumatic diseases, 2016, Volume: 75, Issue:6

    Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Bone Marrow; Bone Marrow Diseases; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Edema; Female; Hand; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Synovitis; Treatment Outcome; Wrist Joint

2016
Phase I pharmacokinetic and pharmacodynamic study of SJG-136, a novel DNA sequence selective minor groove cross-linking agent, in advanced solid tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Jun-01, Volume: 17, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Benzodiazepinones; Dexamethasone; Dyspnea; Edema; Fatigue; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Pyrroles

2011
A vasopressin receptor antagonist (VPA-985) improves serum sodium concentration in patients with hyponatremia: a multicenter, randomized, placebo-controlled trial.
    Hepatology (Baltimore, Md.), 2003, Volume: 37, Issue:1

    Topics: Aldosterone; Antidiuretic Hormone Receptor Antagonists; Ascites; Azepines; Benzamides; Edema; Female; Heart Failure; Hemodynamics; Humans; Hyponatremia; Inappropriate ADH Syndrome; Liver Cirrhosis; Male; Middle Aged; Norepinephrine; Pyrroles; Renin; Sodium; Thirst; Treatment Outcome; Water-Electrolyte Balance

2003
A phase II, pharmacokinetic, and biologic study of semaxanib and thalidomide in patients with metastatic melanoma.
    Cancer chemotherapy and pharmacology, 2007, Volume: 59, Issue:2

    Topics: Adult; Aged; Angiogenesis Inhibitors; Area Under Curve; Asthenia; Dose-Response Relationship, Drug; Edema; Female; Half-Life; Headache; Humans; Indoles; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Peripheral Nervous System Diseases; Protein Kinase Inhibitors; Pyrroles; Thalidomide; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Venous Thrombosis

2007

Other Studies

72 other study(ies) available for pyrroles and Edema

ArticleYear
Bilateral periorbital, eyelid, and conjunctival edema and hair color changes caused by avapritinib.
    Journal francais d'ophtalmologie, 2022, Volume: 45, Issue:5

    Topics: Conjunctival Diseases; Edema; Eyelid Diseases; Eyelids; Hair Color; Humans; Pyrazoles; Pyrroles; Triazines

2022
Synthesis and highly potent anti-inflammatory activity of licofelone- and ketorolac-based 1-arylpyrrolizin-3-ones.
    Bioorganic & medicinal chemistry, 2019, 10-15, Volume: 27, Issue:20

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Edema; Ketorolac; Lipopolysaccharides; Macrophages; Male; Mice; Molecular Docking Simulation; Molecular Structure; Nitric Oxide; Pyrroles; Structure-Activity Relationship; Tetradecanoylphorbol Acetate

2019
Ethyl benzoate bearing pyrrolizine/indolizine moieties: Design, synthesis and biological evaluation of anti-inflammatory and cytotoxic activities.
    Bioorganic chemistry, 2020, Volume: 94

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Benzoates; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Edema; Humans; Indolizines; Inflammation; Molecular Structure; Pain; Pyrroles; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

2020
Protein losing gastroenteropathy due to
    BMJ case reports, 2019, Nov-19, Volume: 12, Issue:11

    Topics: Aged, 80 and over; Anti-Bacterial Agents; Diagnosis, Differential; Drug Therapy, Combination; Edema; Endoscopy; Female; Gastric Mucosa; Gastrointestinal Diseases; Helicobacter Infections; Helicobacter pylori; Humans; Hypoproteinemia; Protein-Losing Enteropathies; Pyrroles; Radionuclide Imaging; Sulfonamides; Technetium Tc 99m Aggregated Albumin; Treatment Outcome

2019
In Vivo Evaluation of Anti-inflammatory Activity of 2-[3-Acetyl- 5-(4-chloro-phenyl)-2-methyl-pyrrol-1-yl]-4-methylsulfanylbutyric Acid.
    Folia medica, 2018, Jun-01, Volume: 60, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Butyrates; Carrageenan; Diclofenac; Edema; Foot; Hindlimb; Inflammation; Pyrroles; Rats

2018
Biological Screening of Novel Structural Analog of Celecoxib as Potential Anti-Inflammatory and Analgesic Agent.
    Medicina (Kaunas, Lithuania), 2019, Apr-05, Volume: 55, Issue:4

    Topics: Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Blood Platelets; Carrageenan; Celecoxib; Drug Evaluation, Preclinical; Edema; Erythrocytes; Hemoglobins; Indoles; Leukocytes; Male; Models, Animal; Pain Measurement; Pyrroles; Rats; Rats, Wistar

2019
Modeling Combined Anti-Inflammatory Effects of Dexamethasone and Tofacitinib in Arthritic Rats.
    The AAPS journal, 2019, 07-24, Volume: 21, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Dexamethasone; Disease Progression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Edema; Male; Pilot Projects; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Inbred Lew

2019
Incidence of bowel wall oedema on computed tomography exams and association with diarrhoea in renal cell carcinoma patients treated with sunitinib.
    European radiology, 2015, Volume: 25, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Belgium; Carcinoma, Renal Cell; Diarrhea; Edema; Female; Follow-Up Studies; Humans; Incidence; Indoles; Intestines; Kidney Neoplasms; Male; Middle Aged; Multidetector Computed Tomography; Pyrroles; Retrospective Studies; Sunitinib

2015
Synthesis and Pharmacochemistry of New Pleiotropic Pyrrolyl Derivatives.
    Molecules (Basel, Switzerland), 2015, Sep-10, Volume: 20, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biphenyl Compounds; Carrageenan; Chalcones; Edema; Lipid Peroxidation; Lipoxygenase; Picrates; Prostaglandin-Endoperoxide Synthases; Pyrroles; Rats

2015
Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity.
    European journal of medicinal chemistry, 2016, Feb-15, Volume: 109

    Topics: Adult; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Halogenation; Humans; Hyperalgesia; Models, Molecular; Pyrroles; Rats; Skin; Skin Neoplasms

2016
Rational Design and Synthesis of Biologically Active Disubstituted 2(3H) Furanones and Pyrrolone Derivatives as Potent and Safer Non Steroidal Anti-inflammatory Agents.
    Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2016, Volume: 15, Issue:1

    Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Female; Furans; Male; Mice; Molecular Docking Simulation; Pain; Pyrroles; Rats, Wistar; Stomach Ulcer

2016
Effects of baicalin on alveolar fluid clearance and α-ENaC expression in rats with LPS-induced acute lung injury.
    Canadian journal of physiology and pharmacology, 2017, Volume: 95, Issue:2

    Topics: Acute Lung Injury; Adenylyl Cyclase Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Edema; Epithelial Cells; Epithelial Sodium Channels; Flavonoids; Ionomycin; Lipopolysaccharides; Lung; Male; Mice; Protein Kinase Inhibitors; Pyrroles; Rats; Water

2017
Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity.
    Journal of medicinal chemistry, 2008, Aug-14, Volume: 51, Issue:15

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Computer Simulation; Cyclooxygenase 2 Inhibitors; Edema; Ether; Humans; Hydrophobic and Hydrophilic Interactions; Male; Mice; Models, Molecular; Molecular Structure; Pyrroles; Rats; Structure-Activity Relationship

2008
Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.
    Bioorganic & medicinal chemistry, 2008, Sep-01, Volume: 16, Issue:17

    Topics: Acetic Acid; Alcohols; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Carrageenan; Cells, Cultured; Computer Simulation; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Edema; Enzyme Activation; Enzyme Inhibitors; Ethers; Humans; Isoenzymes; Male; Mice; Models, Chemical; Molecular Structure; Pain; Pain Measurement; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship

2008
Synthesis and pharmacological evaluation of 2(3H)-furanones and 2(3H)-pyrrolones, combining analgesic and anti-inflammatory properties with reduced gastrointestinal toxicity and lipid peroxidation.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:6

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; Furans; Lipid Peroxidation; Male; Mice; Molecular Structure; Pain Measurement; Peptic Ulcer; Pyrroles; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship

2009
Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib.
    Bioorganic & medicinal chemistry letters, 2009, Apr-15, Volume: 19, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Edema; Humans; Mice; Pyrazoles; Pyrroles; Rats; Sulfides; Sulfonamides

2009
Novel substituted and fused pyrrolizine derivatives: synthesis, anti-inflammatory and ulcerogenecity studies.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:2

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Edema; Female; Male; Mice; Pyrroles; Rats; Ulcer

2010
Antioxidant, antinociceptive and anti-inflammatory activities of atorvastatin and rosuvastatin in various experimental models.
    Inflammopharmacology, 2010, Volume: 18, Issue:4

    Topics: Alkaline Phosphatase; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Atorvastatin; Edema; Fluorobenzenes; Granuloma; Heptanoic Acids; L-Lactate Dehydrogenase; Liver; Mice; Pain; Pain Measurement; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Rosuvastatin Calcium; Stomach Ulcer; Sulfonamides

2010
Synthesis and molecular modeling studies of anti-inflammatory active 1H-pyrrolizine-5-carboxamides.
    Archiv der Pharmazie, 2011, Volume: 344, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Disease Models, Animal; Edema; Female; Heterocyclic Compounds; Inflammation; Male; Models, Molecular; Pyrroles; Rats; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship

2011
Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cyclooxygenase Inhibitors; Edema; Female; Male; Mice; Pyrroles

2011
Synthesis, in silico docking experiments of new 2-pyrrolidinone derivatives and study of their anti-inflammatory activity.
    Bioorganic & medicinal chemistry, 2011, May-01, Volume: 19, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Catalytic Domain; Computer Simulation; Edema; Imidazoles; Lipoxygenases; Pyrroles; Pyrrolidinones; Rats

2011
New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:7

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacillus subtilis; Carrageenan; Edema; Hindlimb; Ibuprofen; Male; Microbial Sensitivity Tests; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Staphylococcus aureus; Structure-Activity Relationship

2011
Evaluation of anti-inflammatory, anti-nociceptive, and anti-ulcerogenic activities of novel synthesized thiazolyl and pyrrolyl steroids.
    Archiv der Pharmazie, 2011, Volume: 344, Issue:9

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Carrageenan; Disease Models, Animal; Edema; Inflammation; Pain; Pyrroles; Rats; Rats, Sprague-Dawley; Steroids; Stomach Ulcer; Thiazoles; Ulcer

2011
Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties.
    Journal of medicinal chemistry, 2011, Nov-24, Volume: 54, Issue:22

    Topics: Acetates; Animals; Cell Line; Constriction, Pathologic; Cyclooxygenase 2 Inhibitors; Edema; Esters; Humans; Hyperalgesia; In Vitro Techniques; Isoenzymes; Macrophages; Male; Mice; Models, Molecular; Nitric Oxide Donors; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Structure-Activity Relationship; Vasodilator Agents

2011
Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study.
    British journal of pharmacology, 2012, Volume: 166, Issue:4

    Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Crotonates; Dihydroorotate Dehydrogenase; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Gastrointestinal Tract; Half-Life; Hydroxybutyrates; Hypercholesterolemia; Immunosuppressive Agents; Janus Kinases; Joints; Leukocyte Disorders; Male; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; p38 Mitogen-Activated Protein Kinases; Piperidines; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Splenomegaly; Toluidines; Weight Loss

2012
[5,6-diaryl-2,3-dihydro-1-pyrrolizinone derivatives synthesis and antiiflammatory and analgesic activities].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2001, Volume: 36, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Mice; Molecular Structure; Pyrroles

2001
Synthesis and biological evaluation of thiophene [3,2-b] pyrrole derivatives as potential anti-inflammatory agents.
    Bioorganic & medicinal chemistry, 2004, Mar-01, Volume: 12, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Female; Male; Piroxicam; Pyrroles; Rats; Rats, Wistar; Structure-Activity Relationship; Thiophenes

2004
Imrecoxib: a novel and selective cyclooxygenase 2 inhibitor with anti-inflammatory effect.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Humans; Isoenzymes; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Prostaglandin-Endoperoxide Synthases; Pyrroles; Rats; Rats, Wistar; RNA, Messenger; Sulfides; U937 Cells

2004
Cyclical Cushing's disease causing recurrent oedema and knee effusions.
    Internal medicine journal, 2005, Volume: 35, Issue:3

    Topics: Adult; Antihypertensive Agents; Atorvastatin; Diuretics; Drug Therapy, Combination; Edema; Enalapril; Follow-Up Studies; Heptanoic Acids; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Knee; Male; Pituitary ACTH Hypersecretion; Pyrroles; Sodium Chloride Symporter Inhibitors

2005
3D-QSAR and preliminary evaluation of anti-inflammatory activity of series of N-pyrrolylcarboxylic acids.
    Farmaco (Societa chimica italiana : 1989), 2005, Volume: 60, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Indomethacin; Prostaglandin-Endoperoxide Synthases; Pyrroles; Quantitative Structure-Activity Relationship; Rats; Structure-Activity Relationship

2005
Anti-inflammatory and analgesic effects of atorvastatin in a rat model of adjuvant-induced arthritis.
    European journal of pharmacology, 2005, Jun-15, Volume: 516, Issue:3

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Atorvastatin; Chemokine CCL2; Chemokine CCL5; Chemokines, CC; Dose-Response Relationship, Drug; Edema; Female; Heptanoic Acids; Hindlimb; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperalgesia; Interleukin-1; Interleukin-10; Interleukin-6; Leukocytes; Neutrophils; Peroxidase; Pyrroles; Rats; Tarsal Joints; Time Factors; Tumor Necrosis Factor-alpha

2005
Anti-inflammatory effect of licofelone against various inflammatory challenges.
    Fundamental & clinical pharmacology, 2006, Volume: 20, Issue:1

    Topics: Acetates; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Female; Freund's Adjuvant; Granuloma; Hyperalgesia; Indomethacin; Lipoxygenase Inhibitors; Mice; Pain Measurement; Pain Threshold; Pyrroles; Rats; Rats, Wistar; Time Factors; Touch

2006
Ligand-based design, synthesis and primary in vivo screening of pyrrole derivatives as potential tricyclic anti-inflammatory agents.
    Arzneimittel-Forschung, 2006, Volume: 56, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Celecoxib; Chromatography, Thin Layer; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Design; Drug Evaluation, Preclinical; Edema; Foot; Injections, Intraperitoneal; Ligands; Magnetic Resonance Spectroscopy; Male; Mice; Pyrazoles; Pyrroles; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Structure-Activity Relationship; Sulfonamides

2006
Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system.
    Bioorganic & medicinal chemistry, 2007, Jul-15, Volume: 15, Issue:14

    Topics: Animals; Anti-Inflammatory Agents; Benzene; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Edema; Male; Molecular Structure; Oxyquinoline; Pyrroles; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

2007
Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity.
    Journal of medicinal chemistry, 2007, Nov-01, Volume: 50, Issue:22

    Topics: Acetates; Adult; Animals; Carrageenan; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Edema; Female; Humans; Male; Mice; Models, Molecular; Pain Measurement; Pyrroles; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Structure-Activity Relationship; T-Box Domain Proteins

2007
A novel synthesis of arylpyrrolo[1,2-a]pyrazinone derivatives.
    Molecules (Basel, Switzerland), 2004, Jun-30, Volume: 9, Issue:7

    Topics: Animals; Cyclization; Drug Evaluation, Preclinical; Edema; Male; Mice; Pyrazines; Pyrroles

2004
Biphasic effects of atorvastatin on inflammation.
    Pakistan journal of pharmaceutical sciences, 2008, Volume: 21, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Anticholesteremic Agents; Atorvastatin; Carrageenan; Edema; Heptanoic Acids; Hindlimb; Inflammation; Male; Mevalonic Acid; Mice; Pyrroles; Rats; Rats, Wistar

2008
[Non-steroidal anti-inflammatory agents. III. Synthesis and analgesic-anti-inflammatory activity of 4-(pyrrol-1-yl)phenylacetamides and 4-(pyrrol-1-yl)phenethylamines].
    Il Farmaco; edizione scientifica, 1984, Volume: 39, Issue:9

    Topics: Acetamides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemical Phenomena; Chemistry; Edema; Mice; Phenethylamines; Pyrroles; Rats; Rats, Inbred Strains

1984
Synthesis and pharmacological evaluation of a series of analgesic and antiinflammatory 4-aminopyrroles.
    Il Farmaco; edizione scientifica, 1984, Volume: 39, Issue:6

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Arthritis, Experimental; Carrageenan; Chemical Phenomena; Chemistry; Diarrhea; Edema; Lethal Dose 50; Male; Pyrroles; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Ulcer

1984
[Effect of a non-steroidal anti-inflammatory drug, tolmetin sodium on arthritic pain, traumatic edema and LPS-induced fever (author's transl)].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1981, Volume: 101, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Edema; Fever; Lipopolysaccharides; Male; Pyrroles; Rats; Rats, Inbred Strains; Tolmetin

1981
[Preliminary pharmacological studies of a new anti-inflammatory agent: 4'-acetamidophenyl-2-(5'-p-toluyl-1'-methylpyrrole)acetate].
    Bollettino chimico farmaceutico, 1982, Volume: 121, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Evaluation, Preclinical; Edema; Male; Pain; Pyrroles; Rats; Rats, Inbred Strains; Tolmetin

1982
[Analgesic activity of a non-steroidal antiinflammatory drug, zomepirac sodium, in experimental animals].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1982, Volume: 79, Issue:6

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Blood Pressure; Bradykinin; Dogs; Edema; Female; Lethal Dose 50; Male; Mice; Pyrroles; Rabbits; Rats; Rats, Inbred Strains; Tolmetin

1982
The analgesic and anti-inflammatory profile of (+/-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2a]pyrrole-1-carboxylic acid (RS-37619).
    Agents and actions, 1982, Volume: 12, Issue:5-6

    Topics: Adrenal Cortex Hormones; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cardiovascular System; Central Nervous System; Digestive System; Edema; Granuloma; Ketorolac; Mice; Mice, Inbred Strains; Pain; Pyrroles; Rats; Rats, Inbred Strains; Tolmetin

1982
[Anti-inflammatory activity of a non-steroidal anti-inflammatory agent, zomepirac sodium, in experimental animals].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1982, Volume: 79, Issue:6

    Topics: Adrenalectomy; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Capillary Permeability; Depression, Chemical; Edema; Guinea Pigs; In Vitro Techniques; Male; Mice; Peptic Ulcer; Prostaglandins; Protein Denaturation; Pyrroles; Rabbits; Rats; Tolmetin

1982
Effect of a 5-HT1 receptor agonist, CP-122,288, on oedema formation induced by stimulation of the rat saphenous nerve.
    British journal of pharmacology, 1995, Volume: 115, Issue:1

    Topics: Analysis of Variance; Animals; Edema; Electric Stimulation; Male; Neuritis; Neurons, Afferent; Pyridines; Pyrroles; Pyrrolidines; Rats; Rats, Wistar; Serotonin Receptor Agonists; Sumatriptan

1995
Effect of aminoethylpyrroles on carrageenan-induced inflammation and on lipid peroxidation in rats: some structural aspects.
    The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carrageenan; Edema; Inflammation; Lipid Peroxidation; Male; Microsomes, Liver; Pyrroles; Rats; Rats, Inbred F344; Structure-Activity Relationship

1994
Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4- chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid.
    Arzneimittel-Forschung, 1995, Volume: 45, Issue:1

    Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Body Weight; Carrageenan; Cyclooxygenase Inhibitors; Edema; Female; Foot; Indomethacin; Male; Pyrroles; Rats; Rats, Wistar

1995
Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase.
    Arzneimittel-Forschung, 1994, Volume: 44, Issue:5

    Topics: Acetates; Animals; Arachidonic Acid; Arthritis, Experimental; Benzoquinones; Blood Coagulation; Bronchoconstriction; Carrageenan; Cyclooxygenase Inhibitors; Edema; Female; Guinea Pigs; In Vitro Techniques; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; Pain Measurement; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Rats; Rats, Sprague-Dawley; Yeast, Dried

1994
Evaluation of the anti-inflammatory and liver-protective effects of anoectochilus formosanus, ganoderma lucidum and gynostemma pentaphyllum in rats.
    The American journal of Chinese medicine, 1993, Volume: 21, Issue:1

    Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Biopsy; Carbon Tetrachloride; Carrageenan; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Edema; Liver Diseases; Male; Pyrroles; Rats; Rats, Wistar

1993
Effect of KBT-3022, a new diphenylthiazole derivative, on platelet functions.
    The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:9

    Topics: Adenosine Diphosphate; Administration, Oral; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Edema; Erythema; Gastric Mucosa; Guinea Pigs; Humans; Mice; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Rats; Serotonin; Species Specificity; Thiazoles; Thrombin; Ultraviolet Rays

1995
Pyrrole detection and the pathologic progression of Cynoglossum officinale (houndstongue) poisoning in horses.
    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 1996, Volume: 8, Issue:1

    Topics: Alkaloids; Animals; Biopsy; Cecum; Colon; Dermatitis; Edema; Horse Diseases; Horses; Infarction; Liver; Necrosis; Plants, Toxic; Poisoning; Pyrroles

1996
1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase-2.
    Journal of medicinal chemistry, 1997, May-23, Volume: 40, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Humans; Isoenzymes; Membrane Proteins; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Pyrroles; Rats; Recombinant Proteins; Structure-Activity Relationship; Sulfonamides

1997
A pyrroloquinazoline derivative with anti-inflammatory and analgesic activity by dual inhibition of cyclo-oxygenase-2 and 5-lipoxygenase.
    European journal of pharmacology, 2002, Jan-11, Volume: 434, Issue:3

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Female; Humans; Isoenzymes; Lipoxygenase Inhibitors; Membrane Proteins; Mice; Monocytes; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Pyrroles; Quinazolines; Quinolines; Sheep

2002
The mechanism of action of the new antiinflammatory compound ML3000: inhibition of 5-LOX and COX-1/2.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2002, Volume: 51, Issue:3

    Topics: Acetates; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Cyclooxygenase Inhibitors; Edema; Gastric Mucosa; Humans; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stomach; Thromboxane B2

2002
The role of copper in preventing gastrointestinal damage by acidic anti-inflammatory drugs.
    The Journal of pharmacy and pharmacology, 1976, Volume: 28, Issue:12

    Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chelating Agents; Copper; Edema; Female; In Vitro Techniques; Indomethacin; Ketoprofen; Male; Naproxen; Niflumic Acid; Peptic Ulcer; Prostaglandins E; Pyrroles; Rats

1976
[Effect of a non-steroidal anti-inflammatory agent, tolmetin sodium on exudative inflammation in experimental animals (author's transl)].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1979, Volume: 75, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; Cell Differentiation; Edema; Erythrocyte Membrane; Exudates and Transudates; Guinea Pigs; Hemolysis; Hot Temperature; In Vitro Techniques; Inflammation; Kaolin; Lymphocytes; Male; Mice; Protein Denaturation; Pyrroles; Rats; Sunburn; Tolmetin

1979
Synthesis and anti-inflammatory properties of some pyrrolo(1H,3H)[3,4-d]pyrimidin-2-ones and pyrrolo(1H,6H)[3,4-d]pyrimidin-2-ones.
    Il Farmaco; edizione scientifica, 1979, Volume: 34, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Edema; Female; Indomethacin; Male; Mice; Pyrimidinones; Pyrroles; Rats

1979
Non-steroid anti-inflammatory drugs: combined assay for anti-edemic potency and gastric ulcerogenesis in the same animal.
    Life sciences, 1977, Aug-01, Volume: 21, Issue:3

    Topics: Acacia; Adjuvants, Pharmaceutic; Animals; Aspartic Acid; Aspirin; Carrageenan; Diclofenac; Drug Evaluation, Preclinical; Edema; Female; Glucose; Glycyrrhiza; Male; Phenylacetates; Plants, Medicinal; Pyrroles; Rats; Salicylates; Stomach Ulcer; Tolmetin

1977
Synthesis and pharmacological properties of derivatives of pyrrolo(3,4-d)pyrimidines and pyrrolo(3,4-b)pyridines (I).
    Il Farmaco; edizione scientifica, 1976, Volume: 31, Issue:2

    Topics: Animals; Edema; Female; Prostaglandins; Pyridines; Pyrimidines; Pyrroles; Rats

1976
1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with antiinflammatory activity.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Cell Line; Cyclooxygenase Inhibitors; Edema; Indicators and Reagents; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Models, Molecular; Molecular Structure; Prostaglandin Antagonists; Pyrroles; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiazines

1990
Profile of activity of a new anti-inflammatory agent, ST 679 (MED 15).
    Drugs under experimental and clinical research, 1990, Volume: 16, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Concanavalin A; Dose-Response Relationship, Drug; Drug Administration Schedule; Edema; Female; Glycine; Inflammation; Nystatin; Pyrroles; Rats; Rats, Inbred Strains

1990
Synthesis and antiinflammatory and analgesic activity of 5-aroyl-6-(methylthio)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-ca rboxyl ic acids and 1-methyl-4-(methylthio)-5-aroylpyrrole-2-acetic acids.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:6

    Topics: Acetates; Analgesia; Animals; Aspirin; Benzoquinones; Carboxylic Acids; Carrageenan; Chemical Phenomena; Chemistry; Edema; Inflammation; Mice; Molecular Structure; Pain Measurement; Phenylbutazone; Pyrroles; Quinones; Rats

1989
Pharmacological study of the new nonsteroidal antiinflammatory agent 4'-acetamidophenyl-2-(5'-p-toluyl-1'-methylpyrrole)acetate.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Arthritis, Experimental; Carrageenan; Edema; Female; Gossypium; Guinea Pigs; Hemodynamics; Male; Mice; Platelet Aggregation; Psychomotor Performance; Pyrroles; Rats; Rats, Inbred Strains; Reaction Time; Stomach Ulcer; Tolmetin

1988
Pharmacological activity of some pyrrolo and pyrazolo pyrimidine derivatives.
    Il Farmaco; edizione scientifica, 1987, Volume: 42, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Humans; In Vitro Techniques; Indomethacin; Lethal Dose 50; Male; Platelet Aggregation Inhibitors; Pyrazoles; Pyrimidines; Pyrroles; Rats; Restraint, Physical; Stomach Ulcer

1987
Synthesis and antiinflammatory and analgesic activity of 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and related compounds.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:8

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Edema; Male; Mice; Pain; Pyrroles; Rats; Structure-Activity Relationship

1985
Pharmacologic evaluation of tolectin (tolmetin, mcn-2559) and mcn-2891, two anti-inflammatory agents.
    The Journal of pharmacology and experimental therapeutics, 1973, Volume: 185, Issue:1

    Topics: Acetylcholine; Analysis of Variance; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Behavior, Animal; Benzoates; Blood Pressure; Carrageenan; Dose-Response Relationship, Drug; Edema; Female; Freund's Adjuvant; Heart; Indomethacin; Male; Osteoarthritis; Phenylbutazone; Pyrroles; Quinones; Rats; Saccharomyces cerevisiae; Toluene

1973
5-Benzoyl-1-methylpyrrole-2-acetic acids as antiinflammatory agents. 2. The 4-methyl compounds.
    Journal of medicinal chemistry, 1973, Volume: 16, Issue:2

    Topics: Acetates; Animals; Anti-Inflammatory Agents; Benzoates; Carrageenan; Edema; Kaolin; Methylation; Pyrroles; Structure-Activity Relationship

1973
4-Anilino-1-phenyl-3-pyrrolecarboxylic acids. Analogs of the fenamic acids.
    Journal of medicinal chemistry, 1972, Volume: 15, Issue:4

    Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents; Arthritis; Benzoates; Carboxylic Acids; Carrageenan; Edema; Foot; ortho-Aminobenzoates; Pyrroles; Rats; Structure-Activity Relationship

1972
[Anti-inflammatory effect of bimetopyrol. I. Suppressive effect on acute inflammation].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1972, Volume: 92, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cyproheptadine; Edema; Erythema; Fever; Flufenamic Acid; Glucocorticoids; Granuloma; Indomethacin; Lethal Dose 50; Male; Mice; Phenylbutazone; Pyrroles; Rats; Rats, Inbred Strains; Triamcinolone Acetonide

1972
[Anti-inflammatory effect of bimetopyrol. 3. Possible active substance and site of action].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1972, Volume: 92, Issue:3

    Topics: Administration, Oral; Adrenalectomy; Animals; Anisoles; Anti-Inflammatory Agents; Binding Sites; Edema; Indomethacin; Injections, Subcutaneous; Male; Phenylbutazone; Pyrroles; Rats; Rats, Inbred Strains

1972
Diaryl pyrroles: a new series of anti-inflammatory agents.
    Experientia, 1972, Aug-15, Volume: 28, Issue:8

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Disease Models, Animal; Edema; Erythema; Female; Guinea Pigs; Hindlimb; Injections, Subcutaneous; Male; Pyrroles; Rats

1972
5-Benzoyl-1-methylpyrrole-2-acetic acids as antiinflammatory agents.
    Journal of medicinal chemistry, 1971, Volume: 14, Issue:17

    Topics: Acetates; Animals; Anti-Inflammatory Agents; Benzoates; Carrageenan; Edema; Granuloma; Indomethacin; Kaolin; Male; Phenylbutazone; Pyrroles; Structure-Activity Relationship

1971