pyrroles has been researched along with Disease Models, Animal in 848 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (0.94) | 18.7374 |
| 1990's | 26 (3.07) | 18.2507 |
| 2000's | 204 (24.06) | 29.6817 |
| 2010's | 534 (62.97) | 24.3611 |
| 2020's | 76 (8.96) | 2.80 |
| Authors | Studies |
|---|---|
| Chapman, RW; Chun, D; Cipolla, D; Corboz, MR; Gauani, H; Li, Z; Malinin, V; Perkins, WR; Plaunt, AJ | 1 |
| Bigby, TD; Breen, EC; Cannon, DT; Gilmore, NK; Gutierrez-Gonzalez, AK; Nogueira, L | 1 |
| Ishida, H; Ishii, R; Katsuragi, S; Kogaki, S; Narita, J; Ozono, K; Suginobe, H; Tsuru, H; Ueyama, A; Wang, R; Yoshihara, C | 1 |
| Akar, FG; Akar, JG; Bisserier, M; Cacheux, M; Fargnoli, A; Hadri, L; Hummel, JP; Katz, MG; Obus, E; Sassi, Y; Strauss, B | 1 |
| Beke, L; Bhargava, V; Boeckx, A; Brehmer, D; De Lange, D; Diels, G; Fan, Y; Fiore, D; Gilbert, A; Graubert, TA; Gu, J; Gustin, EM; Johnson, A; Keersmaekers, V; Laquerre, S; Lorenzi, MV; Mannens, G; Meerpoel, L; Millar, HJ; Morschhäuser, B; Moy, C; Nys, T; Packman, K; Pande, V; Pastore, F; Philippar, U; Rai, S; Safabakhsh, P; Schepens, W; Sun, W; Thuring, JW; van Heerde, E; Verbist, B; Verhulst, T; Viellevoye, M; Vinken, P; Walker, D; Wu, T; Zhou, L | 1 |
| Afarin, R; Akbari, R; Behdarvand, T; Jalali, MT; Mohammadtaghvaei, N; Yaghooti, H | 1 |
| Bora, V; Goyal, RK; Johar, K; Patel, BM; Patel, D | 1 |
| Chen, Y; Gao, M; Guo, Y; Jiang, M; Li, T; Liu, H; Qu, Y; Sun, X; Wan, X; Wang, F; Wang, Y; Zhao, X | 1 |
| Cao, W; Chen, L; Deng, Y; He, J; Li, W; Liu, Z; Luo, M; Shi, M; Wan, W; Xu, Y; Zeng, J; Zhang, Y; Zhong, X | 1 |
| Hishinuma, S; Michinaga, S; Mizuguchi, H; Onishi, K; Shimizu, K | 1 |
| Basta, MD; Paulson, H; Walker, JL | 1 |
| Chen, J; Dai, Y; Nie, X; Shen, C; Sun, H; Tan, J; Wang, W; Wu, Z; Yang, X | 1 |
| Gao, X; Han, Z; Lei, P; Li, M; Li, X; Liu, M; Liu, Q; Zhang, W | 1 |
| Aoyama, Y; Hayashi, Y; Imafuji, H; Kato, T; Kimura, M; Matsuo, Y; Mitsui, A; Morimoto, M; Murase, H; Ogawa, R; Omi, K; Saito, K; Takahashi, H; Takiguchi, S; Tsuboi, K; Ueda, G | 1 |
| Anderson, SA; Chen, LY; Danner, RL; Dougherty, EJ; Elinoff, JM; Gairhe, S; Johnston, KA; Lu, M; Mazer, AJ; Nelson, JNH; Noguchi, A; Siddique, MAH; Solomon, MA; Solomon, SB; Sun, J; Vanderpool, RR; Wang, H; Wang, S; Yu, ZX; Zou, Y | 1 |
| Gong, Y; Hong, Z; Jiang, T; Lu, F; Qiu, J; Wang, Z; Wu, X; Zhang, W; Zheng, X | 1 |
| Feng, Y; Li, Y; Liu, L; Liu, X; Liu, Y; Wang, L; Wu, Q; Zhang, L | 1 |
| Collins, LM; Foley, T; Goulding, SR; Mazzocchi, M; Morales-Prieto, N; O'Keeffe, GW; Sullivan, AM | 1 |
| Li, H; Liu, Z; Shu, J; Su, G; Xu, J; Yang, P; Zhou, C | 1 |
| Appel, D; Hummel, R; Klein, M; Li, S; Ritter, K; Schäfer, MKE; Strehle, J; Tegeder, I; Wang, Y; Wernersbach, I | 1 |
| Cai, Y; Chen, P; Kopchuk, DS; Kovalev, IS; Li, J; Li, S; Ma, L; Wang, Z; Zyryanov, GV | 1 |
| Akcakanat, A; Chen, H; Damodaran, S; DiPeri, TP; Evans, KW; Ha, MJ; Kirby, BP; Meric-Bernstam, F; Mills, GB; Ng, PKS; Rodon Ahnert, J; Saridogan, T; Scott, S; Yuca, E; Zhao, M; Zheng, X | 1 |
| Alexander, G; Bai, D; Chhonker, YS; Coulter, DW; Li, J; Li, R; Liu, Y; McGuire, TR; McIntyre, EM; Murry, DJ; Qiao, Z; Sharp, JG; Sughroue, JA; Yang, Z | 1 |
| Campbell, H; Davies, BR; De Velasco, MA; Hatanaka, Y; Kim, Y; Klein, S; Kura, Y; MacLeod, AR; Nishio, K; Sakai, K; Sugimoto, K; Uemura, H; Yoshikawa, K | 1 |
| Batista, DDGJ; Caljon, G; da Silva, CF; Hulpia, F; Lin, C; Maes, L; Soeiro, MNC; Van Calenbergh, S; Van Hecke, K | 1 |
| Altamirano-Lagos, MJ; Fernández-Fierro, A; Funes, SC; Gómez-Santander, F; Jara, EL; Kalergis, AM; Mackern-Oberti, JP; Pulgar-Sepúlveda, R; Rebolledo-Zelada, D; Ríos, M; Rivera-Perez, D; Roa, JC; Villarroel, A | 1 |
| Burvenich, IJG; Harris, MA; Hawkins, CJ; Parker, BS; Rigopoulos, A; Scott, AM; Shekhar, TM; Spurling, A; Walkley, CR; Zanker, D | 1 |
| Balansky, R; De Flora, S; Izzotti, A; La Maestra, S; Micale, RT; Pulliero, A | 1 |
| Holtzman, DM; Hoyle, R; Long, J; Manis, M; Remolina Serrano, J; Shi, Y; Sullivan, PM; Wang, K | 1 |
| Baht, GS; Gelbard, HA; Kong, C; Miller-Rhodes, P; Rodriguiz, RM; Saminathan, P; Terrando, N; Wetsel, WC | 1 |
| Gao, X; Li, S; Liu, Y; Pan, X; Sun, H; Wang, C; Wang, Q; Zhang, M; Zhang, X; Zhang, Y; Zhu, W | 1 |
| Benninger, F; Lenz, M; Maggio, N; Neufeld, MY; Shavit-Stein, E; Shimon, MB; Vlachos, A | 1 |
| Dhammu, TS; Khan, M; Kumar, P; Qiao, F; Singh, AK; Singh, I | 1 |
| Bako, HY; Ibrahim, MA; Ibrahim, S; Isah, MS | 1 |
| Fujiwara, Y; Hattori, M; Higashimori, A; Hosomi, S; Kamata, N; Kosaka, S; Matsumoto, Y; Nadatani, Y; Nagami, Y; Nakata, A; Otani, K; Suda, W; Taira, K; Tanaka, F; Tanigawa, T; Watanabe, T; Yamagami, H | 1 |
| Li, B; Li, C; Qiu, X; Song, C; Wang, L; Wang, Q; Wen, F; Xing, MMQ; Xiong, W; Xu, K; Zhang, X | 1 |
| Di Ciano, P; Kim, A; Le Foll, B; Leca, J; Pushparaj, A | 1 |
| Kato, F; Kurosaka, D; Oto, Y; Takahashi, Y | 1 |
| Crapser, JD; Green, KN; Ochaba, J; Reidling, JC; Soni, N; Thompson, LM | 1 |
| Andrew, AK; Cooper, CA; Moore, JM; Morffy Smith, CD; Russ, BN | 1 |
| Amano, W; Egawa, G; Hamada, Y; Hayashi, M; Honda, T; Ishida, Y; Kabashima, K; Konishi, N; Matsushita, M; Nakashima, C; Otsuka, A; Tanimoto, A; Usui, K; Wada, M; Yamamoto, Y | 1 |
| Appleyard, CB; Gorabi, V; Rana, M; Rivera-Lopez, LL; Torres-Reverón, A | 1 |
| Cano, M; Gad, M; Green, KN; Leslie, FM; Linker, KE; Tawadrous, P; Wood, MA | 1 |
| Chen, FH; Chernikov, OV; Chiu, HW; Fang, Z; Gan, CH; Hsieh, CY; Hsu, CH; Hua, KF; Ju, TC; Lam, Y; Li, LH; Liu, ML; Rao, YK; Wong, WT | 1 |
| Besirli, CG; Dai, L; Hager, H; Lyssiotis, CA; Pai, MP; Pawar, M; Sajjakulnukit, P; Smith, A; Weh, E; Wubben, TJ; Zhang, L | 1 |
| Aoyagi, H; Hirasawa, N; Kajiwara, D; Miyoshi, K; Tanaka, K; Tsunekuni, K | 1 |
| Chen, A; Duncan, L; Jensen, C; Kong, FC; Kurago, ZB; Lam, T; Lang, L; Shay, C; Teng, Y | 1 |
| Aricioglu, F; Bekci, H; Cumaoglu, A; Unal, G; Yerer, MB | 1 |
| Ding, Y; Huang, W; Kong, H; Liu, P; Peng, L; Tan, Q; Wang, H; Wang, J; Wang, Y; Xie, W; Yang, M; Yu, M; Zhou, H | 1 |
| Ren, H; Wang, J; Xue, R; Zhou, Y | 1 |
| Akaike, T; Kuga, K; Kusakari, Y; Minamisawa, S; Semba, K; Uesugi, K; Urashima, T | 1 |
| Feng, W; Islam, SMT; Khan, M; Kumar, P; Qiao, F; Singh, AK; Singh, I; Won, JS | 1 |
| Chen, H; Chen, J; Chen, Y; Duan, X; He, W; Hou, C; Jiang, Q; Kuang, M; Li, Y; Liao, J; Liu, S; Lu, W; Luo, X; Tang, H; Wang, J; Yan, H; Yang, K; Zheng, Q; Zhou, Y; Zou, G | 1 |
| Hanada, K; Itoh, K; Kato, T; Kawamura, Y; Kitayama, K; Kudo, N; Miura, N; Nakata, M; Narita, M; Nozaka, M; Tatara, Y; Tomita, H; Toyama, Y; Tsushima, M; Yokono, Y | 1 |
| Butcher, EC; Dahms, P; Gandjeva, A; Granucci, E; Jiang, X; Nicolls, MR; Pasupneti, S; Semenza, GL; Tian, W; Tu, AB; Tuder, RM; Xiang, M | 1 |
| Alonso, C; Bedossa, P; Bhat, M; Caffrey, R; Giri, SR; Jain, MR; Koduru, SV; Kumar, DP; Marioneaux, J; Philip, B; Santhekadur, PK; Sanyal, AJ | 1 |
| Bikou, O; Hadri, L; Hajjar, RJ; Sassi, Y | 1 |
| Álvarez-Mejía, L; Buzoianu-Anguiano, V; Coyoy-Salgado, A; Cruz, GJ; Damián-Matsumura, P; Díaz-Ruíz, A; Fabela-Sánchez, O; González-Ruiz, C; Mondragón-Lozano, R; Morales, J; Morales-Guadarrama, A; Olayo, MG; Olayo, R; Orozco-Barrios, C; Orozco-Suárez, S; Ríos, C; Salgado-Ceballos, H; Sánchez-Torres, S | 1 |
| Banerjee, P; Behravesh, S; Dodick, DW; Navratilova, E; Oyarzo, J; Porreca, F | 1 |
| Bian, JS; Chen, J; Chen, Y; Dai, Y; Nie, X; Shen, C; Tan, J; Wang, W; Wu, Z; Yang, X; Ye, S | 1 |
| Choi, HD; Choi, JY; Jeong, YJ; Lee, HJ; Nam, KR; Oh, SJ; Shin, NR; Son, Y | 1 |
| Chen, W; Mai, Z; Rong, Z; Su, X; Wan, C; Wu, Q; Wu, Y; Xue, Y; Yu, X; Zheng, H | 1 |
| Blazer-Yost, BL; Fulkerson, D; Hochstetler, AE; Preston, DC; Reed, MM; Shim, JW; Smith, HM; Territo, PR | 1 |
| Chen, JC; Liao, IM | 1 |
| Barati, S; Kashani, IR; Madadi, S; Pasbakhsh, P; Tahmasebi, F | 1 |
| Aricioglu, F; Sirvanci, S; Unal, G | 1 |
| Chen, B; Liu, F; Liu, XP; Wang, DC; Xie, YM; Yan, TT | 1 |
| Bartolucci, M; Cancedda, L; Catelani, T; Contestabile, A; Fumagalli, A; Morelli, G; Perlini, LE; Petretto, A; Pinto, B; Rastogi, M; Savardi, A; Varea, E | 1 |
| Fuchikami, C; Honda, Y; Kosugi, K; Kuramoto, K; Kuwano, K; Numakura, Y | 1 |
| Berve, K; Groh, J; Martini, R; West, BL | 1 |
| Alhudaithi, SS; Almuqbil, RM; Bielski, ER; Bos, PD; da Rocha, SRP; Du, W; Sunbul, FS; Zhang, H | 1 |
| Andersen, A; Andersen, S; Axelsen, JB; Bogaard, HJ; da Silva Goncalves Bos, D; de Man, FS; Gomez-Puerto, MC; Goumans, MJ; Kurakula, K; Pan, X; Peters, EL; Schalij, I; Schiepers, REJ; Sun, XQ; Szulcek, R; van der Laarse, WJ; Vonk Noordegraaf, A | 1 |
| Chen, X; Huang, X; Jiang, Y; Li, Y; Liang, Q; Lin, Q; Luo, W; Nong, J; Pinhu, L; Qin, C; Sooranna, SR | 1 |
| Chen, X; Chen, XP; Datta, PK; Dong, SL; Dong, W; Leng, C; Luo, X; Wang, C; Yin, P; Zhang, BH; Zhang, BX | 1 |
| Bin, Y; Chen, X; Chen, Y; Li, G; Yan, H; Zhou, X | 1 |
| Kikuchi, N; Kurosawa, R; Miyata, S; Nakata, T; Nogi, M; Omura, J; Satoh, K; Satoh, T; Shimokawa, H; Shindo, T; Siddique, MAH; Sunamura, S; Takeuchi, Y | 1 |
| Higuchi, T; Inagaki, T; Masaki, T; Nakaoka, Y; Pearson, JT; Saito, S; Schwenke, DO; Shirai, M; Tsuchimochi, H; Umetani, K | 1 |
| Banerjee, S; Clark, VR; Fishbein, G; Hong, J; Park, JF; Razee, A; Saddic, L; Umar, S; Williams, T | 1 |
| Aoki, Y; de Groot, AP; Eguchi, M; Fujiki, S; Hashimoto, M; Ishii, E; Ishikawa, F; Kajita, H; Kaneko, A; Kawakami, E; Koh, K; Mizutani, S; Ogahara, I; Ohara, O; Ono, R; Saito, Y; Sato, K; Shultz, LD; Takagi, M; Tomizawa, D; Watanabe, T | 1 |
| Hata, A; Kato, F; Kobayashi, T; Miwa, H; Nishimura, R; Sakao, S; Sanada, TJ; Shiina, Y; Suzuki, H; Tanabe, N; Tatsumi, K; Voelkel, N; Yoshino, I | 1 |
| Dan, H; Huang, X; Lei, X; Ma, N; Shen, Y; Xing, Y | 1 |
| Bousquet, P; Fellmann, L; Monassier, L; Niederhoffer, N; Regnard, P; Weiss, M | 1 |
| Boyd, MM; Collier, LS; Hagemann, TL; Litscher, SJ; Messing, A; Seitz, LL | 1 |
| Blankenberg, FG; Deuse, T; Fadel, E; Guihaire, J; Reichenspurner, H; Schrepfer, S; Spin, JM; Wang, D | 1 |
| Awada, C; Bonnet, S; Boucherat, O; Bourgeois, A; Breuils-Bonnet, S; Grobs, Y; Lemay, SE; Nadeau, V; Orcholski, M; Paulin, R; Provencher, S; Romanet, C; Shimauchi, K; Toro, V; Tremblay, E | 1 |
| Bahtiar, A; Fujio, Y; Kametani, Y; Kobayashi, A; Maeda, M; Matsumoto, K; Miyake, Y; Mori, S; Obana, M; Tanaka, S; Tomimatsu, M; Wahyuni, T; Yamamoto, A | 1 |
| Barati, S; Kashani, IR; Tahmasebi, F | 1 |
| Ci, L; Dong, H; Fei, J; Huang, F; Li, Q; Liu, Z; Ma, Y; Shen, C; Shen, R; Sun, R; Wang, J; Wang, Z; Yu, M; Zhang, X | 1 |
| Ding, J; Hu, LD; Kong, X; Liao, HP; Ma, QY; Meng, LH; Sun, P; Wang, HL; Wang, RJ; Wang, Y; Xu, L; Zhang, X | 1 |
| He, S; Hou, J; Huang, Q; Tan, G; Xu, F; Yan, J; Yu, X; Zhang, X; Zhang, Z; Zheng, C | 1 |
| Luo, QY; Qiu, ZL; Shen, CT; Song, HJ; Sun, ZK; Wei, WJ; Zhang, XY | 1 |
| Chen, G; He, Y; Jia, D; Liu, H; Lu, A; Yu, Y; Zhu, Q; Zuo, C | 1 |
| Bergh, A; Bergström, SH; Bovinder-Ylitalo, E; Lerner, UH; Nordstrand, A; Thysell, E; Widmark, A; Wikström, P | 1 |
| Hou, L; Li, Q; Liu, Z; Zhang, G; Zhang, M; Zhang, X; Zhou, X; Zhu, L | 1 |
| Fujiwara, Y; Hayashi, T; Ijiri, Y; Imano, H; Izumi, Y; Kato, R; Katsumata, T; Okada, Y; Woo, E; Yamaguchi, T; Yoshiyama, M | 1 |
| Aerts, JG; Bezemer, K; Dammeijer, F; Hegmans, JP; Hendriks, RW; Kaijen-Lambers, ME; Lievense, LA; van Hall, T; van Nimwegen, M | 1 |
| Barrish, JC; Carter, PH; Duan, JJ; Fura, A; Gillooly, K; Hynes, J; Jiang, B; Kempson, J; Khan, JA; Lippy, JS; Lu, Z; McIntyre, K; Nadler, SG; Pitt, S; Pitts, WJ; Sack, JS; Salter-Cid, LM; Schieven, GL; Shen, G; Stachura, S; Tokarski, JS; Wrobleski, ST; Wu, H; Zhang, RF | 1 |
| Chen, Q; Guan, F; Li, M; Wang, J; Wang, W; Wang, Y; Wang, Z; Zhang, W | 1 |
| Aguilar-Pimentel, A; Alessandrini, F; Blank, S; Chaker, A; Fuchs, H; Gailus-Durner, V; Graessel, A; Gutermuth, J; Hrabě de Angelis, M; Ollert, M; Russkamp, D; Schmidt-Weber, CB | 1 |
| Baldwin, GS; Dumesny, CJ; He, H; Huynh, N; Nikfarjam, M; Sandrin, MS; Wang, K; Yim, M | 1 |
| Afif-Rider, S; Bezabeh, B; Breen, S; Chen, C; Dimasi, N; Dixit, R; Gunsior, M; Harper, J; Hinrichs, MJM; Howard, PW; Masterson, L; Patel, N; Rebelatto, M; Reed, M; Ryan, PC; Ryan, PM; Tiberghien, A; Vashisht, K; Yu, XQ; Zheng, B; Zhong, H | 1 |
| Benoit, SM; de la Tremblaye, PB; Plamondon, H; Schock, S | 1 |
| Aisenberg, N; Akirav, I; Sabban, EL; Serova, L | 1 |
| Akkari, L; Huse, JT; Joyce, JA; Kowal, J; Schuhmacher, AJ; West, BL; Yan, D | 1 |
| Higashi, Y; Hondo, T; Inami, M; Inoue, T; Ito, M; Maeda, J; Morio, H; Moritomo, A; Nakajima, Y; Nakamori, F; Nakamura, K; Shirakami, S; Tominaga, H; Usuda, H; Yamagishi, H | 1 |
| Goto, K; Hayashi, T; Inoue, S; Kitadai, Y; Kitano, H; Matsubara, A; Sentani, K; Shinmei, S; Teishima, J; Yasui, W; Yuge, R | 1 |
| Bartko, J; De Vries, F; Derhaschnig, U; Harcken, C; Jilma, B; Leuschner, J; Nabozny, GH; Neels, T | 1 |
| Jiang, H; Liu, D; Liu, Y; Pan, F; Xu, J | 1 |
| Canhão, H; Cascão, R; da Glória, VG; Finnilä, MAJ; Fonseca, JE; Lopes, IP; Saarakkala, S; Vidal, B; Zioupos, P | 1 |
| Fukahori, H; Hanaoka, K; Hirose, J; Inami, M; Ito, M; Kaneko, Y; Kawato, Y; Kubo, K; Maeda, M; Morokata, T; Nakamura, K; Nakanishi, T; Noto, T | 1 |
| Di Cesare Mannelli, L; Farina, C; Ghelardini, C; Maresca, M; Micheli, L; Scherz, MW | 1 |
| Ceric-Dehdari, P; Meurer, M | 1 |
| Higuchi, M; Hikasa, Y; Leong, ZP; Okida, A; Yamano, Y | 1 |
| Berry, GJ; Goronzy, JJ; Tian, L; Watanabe, R; Weyand, CM; Zhang, H | 1 |
| Arcella, A; Esposito, V; Fucile, S; Martinello, K; Mascia, A; Morace, R; Sciaccaluga, M | 1 |
| Cho, S; Kim, E; Park, KW; Yang, J | 1 |
| Alfonso, S; Ballell, L; Barros Aguirre, D; Bates, RH; Biava, M; Cocozza, M; Consalvi, S; De Logu, A; Fernandez-Menendez, R; Poce, G; Venditti, G; Vistoli, G | 1 |
| Belshaw, S; Bower, J; Clarke, M; Cordes, J; Crighton, D; Croft, DR; Drysdale, MJ; Garnett, MJ; Gill, K; Gray, C; Greenhalgh, DA; Hall, JAM; Konczal, J; Lilla, S; McArthur, D; McConnell, P; McDonald, L; McGarry, L; McKinnon, H; McMenemy, C; Mezna, M; Morrice, NA; Munro, J; Naylor, G; Olson, MF; Rath, N; Schüttelkopf, AW; Sime, M; Unbekandt, M | 1 |
| Fukuda, I; Hasegawa, M; Higashino, K; Hinata, M; Horita, N; Ikeda, M; Imai, M; Imai, S; Kanemasa, T; Minami, M; Morioka, Y; Morita, A; Sakaguchi, G; Sanaki, T; Soga, M; Tsuchida, J; Yamamoto, M; Yamane, S; Yoshioka, T | 1 |
| Csernansky, J; Dong, H; Gallardo, C; Hong, E; Keegan, JM; Montalvo-Ortiz, J; Rice, KC; Wang, B | 1 |
| Albay, R; Baglietto-Vargas, D; Glabe, CG; LaFerla, FM; Philipp, S; Reyes-Ruiz, JM; Sosna, J | 1 |
| Strielkov, I; Weissmann, N | 1 |
| Banon-Maneus, E; Brunet, M; Campistol, JM; Cucchiari, D; Diekmann, F; Hierro-Garcia, N; Lazo-Rodríguez, M; Moya-Rull, D; Oppenheimer, F; Piñeiro, GJ; Ramírez-Bajo, MJ; Revuelta, I; Rovira, J; Tubita, V; Ventura-Aguiar, P | 1 |
| Aftab, BT; Ferguson, ID; Hann, BC; Lam, C; Lin, YT; Liu, H; Liu, JO; Mariano, MC; Mitsiades, CS; Murnane, M; Smith, GA; Taunton, J; Wiita, AP; Wong, SW | 1 |
| Dyavarshetty, B; Gelbard, HA; Gendelman, HE; Kiyota, T; Lu, Y; Machhi, J; Mosley, RL; Nemati, M; Zhang, G | 1 |
| Dehpour, AR; Fakhraei, N; Ghasemkhani, N; Mokhtari, R; Mousavi, SE; Saberi, P | 1 |
| Burnouf, T; Chen, CH; Chiang, CW; Chuang, EY; Ho, PH; Jheng, PR; Nyambat, B; Satapathy, MK; Tseng, CL; Wong, PC | 1 |
| Henderson, MX; Lee, VMY; Peng, C; Trojanowski, JQ | 1 |
| Allikmets, R; Cioffi, CL; Johnson, G; Kong, J; Pearson, PG; Petrukhin, K; Racz, B; Varadi, A | 1 |
| Huang, XR; Lan, HY; Meng, XM; Zhang, Y | 1 |
| Grant, FM; Gyori, D; Hawkins, PT; Lim, EL; Okkenhaug, K; Roychoudhuri, R; Shuttleworth, SJ; Spensberger, D; Stephens, LR | 1 |
| Andersen, LMK; Gaustad, JV; Hauge, A; Rofstad, EK; Simonsen, TG; Wegner, CS | 1 |
| Baines, CP; Domeier, TL; Hill, MA; Jones, JL; Karasseva, NG; Krenz, M; Lambert, MD; Lindman, BR; Nourian, Z; Peana, D; Veteto, AB | 1 |
| Bäumer, W; Ehling, S; Fukuyama, T; Wilzopolski, J | 1 |
| Chen, D; Chen, G; Gao, P; Jia, D; Jing, ZC; Liu, G; Liu, J; Liu, Q; Lu, A; Qin, Z; Ruan, C; Shen, Y; Tang, J; Wang, XJ; Wang, Y; Ye, J; Yu, Y; Yuan, P; Zhang, J; Zhang, P; Zhou, Y; Zhu, Q; Zuo, C; Zuo, S | 1 |
| Pei, ZM; Zhu, YH | 1 |
| Bueno-Beti, C; Hadri, L; Hajjar, RJ; Sassi, Y | 1 |
| Abraham, S; Adaikan, G; Beatch, GN; Goldin, AL; Hayes, ES; MacLeod, BA; Pugsley, MK; Saint, DA; Walker, MJA; Wall, RA | 1 |
| Bogaard, HJ; da Silva Gonçalves Bos, D; de Man, FS; de Raaf, MA; Dickhoff, C; Goumans, MJ; Guignabert, C; Happé, C; Herrmann, FE; Koolwijk, P; Kuiper, VP; Kurakula, K; Lodder, K; Pan, X; Rol, N; Schalij, I; Sun, XQ; Szulcek, R; Thuillet, R; Tu, L; van Nieuw Amerongen, GP; Vonk-Noordegraaf, A; Wollin, L | 1 |
| Chen, X; Deng, H; Huang, H; Ji, S; Jin, W; Shen, J; Shen, Q; Tang, H; Yan, P; Zhang, J; Zhao, X | 1 |
| Hikasa, Y; Leong, ZP | 1 |
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| Fujioka, Y; Fujita, H; Gomori, A; Harada, N; Haruma, T; Hashimoto, A; Inada, M; Ito, K; Kataoka, Y; Matsuo, K; Oda, N; Sakuragi, M; Suzuki, T; Tanaka, K; Yamamoto-Yokoi, H; Yonekura, K | 1 |
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| Birnbaum, Y; Lin, Y; Martinez, JD; Perez-Polo, RJ; Uretsky, BF; Ye, Y | 1 |
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19 review(s) available for pyrroles and Disease Models, Animal
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosphate; Adsorption; Adult; Africa, Eastern; Aged; Air Pollutants; Air Pollution; Air Pollution, Indoor; Alcohol Drinking; Allergens; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Immobilized; Antigen Presentation; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Aptamers, Nucleotide; Asthma; Asthma, Exercise-Induced; Atrophy; Autophagy; Azoospermia; Bacillus cereus; Bacterial Infections; Beclin-1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biofouling; Biological Monitoring; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Blastocyst; Bone Neoplasms; Bone Regeneration; Bronchoconstriction; Burkitt Lymphoma; C9orf72 Protein; Campylobacter; Campylobacter Infections; Campylobacter jejuni; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cardiomyopathies; Caregivers; Carmine; Case-Control Studies; Catalysis; Cattle; Cause of Death; CCAAT-Enhancer-Binding Protein-alpha; CD8-Positive T-Lymphocytes; Cefepime; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Transdifferentiation; Chelating Agents; Chemical and Drug Induced Liver Injury, Chronic; Chemoradiotherapy, Adjuvant; Child; Child, Preschool; China; Chlorquinaldol; Cholangiocarcinoma; Cholera; Chromatin; Clinical Trials as Topic; Cognitive Dysfunction; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Colorimetry; Cooking; Coordination Complexes; COVID-19; Creatinine; CRISPR-Cas Systems; Critical Care; Critical Illness; Cross-Sectional Studies; Cryopreservation; Cryoprotective Agents; Cysteine; Cytokines; Device Removal; Diet; Diet, High-Fat; Diet, Mediterranean; Dietary Supplements; Dimethyl Sulfoxide; Dipeptides; Disease Models, Animal; Dithiothreitol; DNA; DNA Repeat Expansion; DNA, Bacterial; DNA, Complementary; Dopamine; Electrochemical Techniques; Electrodes; Endocannabinoids; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Enzyme-Linked Immunosorbent Assay; Erlotinib Hydrochloride; Escherichia coli; Escherichia coli O157; Esophageal Neoplasms; Esophagitis, Peptic; Ethylene Glycol; Europium; Exanthema; Fallopian Tubes; Feces; Female; Fertilization in Vitro; Fluoresceins; Fluorescent Dyes; Follicle Stimulating Hormone; Follow-Up Studies; Food Microbiology; Forced Expiratory Volume; Forkhead Transcription Factors; Frontotemporal Dementia; G-Quadruplexes; Galactose; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Neoplasms; Gastrointestinal Tract; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genital Neoplasms, Female; Genome-Wide Association Study; Genome, Viral; Genomics; Genotype; Glucose; Glutathione; Glycerol; Gold; Graphite; GTPase-Activating Proteins; Heat-Shock Proteins; Heme Oxygenase-1; Hepacivirus; Hepatitis C; Hepatocytes; Histamine; Histocompatibility Antigens Class II; Hoarseness; Hospice and Palliative Care Nursing; Humans; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydroxybenzoates; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Hysteroscopy; Immunoassay; Indigo Carmine; Inflammation; Inflammatory Bowel Diseases; Insulin Resistance; Intensive Care Units; Interleukin-11; Interleukin-6; Interleukins; Iodine Radioisotopes; Iran; Iridium; Islets of Langerhans; Kinetics; Lactation; Lactobacillus; Lactobacillus plantarum; Lamins; Latin America; Lead; Lectins; Leukopenia; Ligands; Limit of Detection; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Cirrhosis; Liver Neoplasms; Lolium; Luminescent Measurements; Luminol; Lung; Luteinizing Hormone; Macrophages; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Malnutrition; Maltose; Manganese Compounds; Maternal Nutritional Physiological Phenomena; Melatonin; Metabolic Engineering; Metal Nanoparticles; Metallocenes; Metaplasia; Methicillin-Resistant Staphylococcus aureus; Methylation; Mevalonic Acid; Mexico; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Microbiota; MicroRNAs; Milk; Mitomycin; Molecular Diagnostic Techniques; Molecular Docking Simulation; Monte Carlo Method; Moringa oleifera; Multiple Sclerosis; Muscle Strength; Muscle, Skeletal; Nanocomposites; Nanotubes, Carbon; Neoadjuvant Therapy; Neoplasms; Neurodegenerative Diseases; Neurotransmitter Agents; NF-E2-Related Factor 2; Nickel; Nitrogen Dioxide; Non-alcoholic Fatty Liver Disease; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Nucleocapsid Proteins; Nutritional Status; Obesity; Osteogenesis; Osteosarcoma; Oxidation-Reduction; Oxides; Oxygen; Oxyquinoline; Pain; Palliative Care; Pancreatic Neoplasms; Pandemics; Particulate Matter; Peroxidase; Peroxidases; Phagocytosis; Phaseolus; Photothermal Therapy; Point-of-Care Systems; Polyethyleneimine; Polymers; Polymorphism, Single Nucleotide; Polysomnography; Postoperative Complications; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Prevalence; Printing, Three-Dimensional; Probability; Probiotics; Prognosis; Prophages; Prospective Studies; Proteomics; Proto-Oncogene Proteins; Pseudomonas aeruginosa; Pseudomonas putida; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Pyridines; Pyrroles; Quality of Life; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Histamine; Receptors, Histamine H2; Recombinases; Rectal Neoplasms; Reperfusion Injury; Respiration; Respiratory Function Tests; Respiratory Rate; Respiratory Sounds; Retrospective Studies; rho GTP-Binding Proteins; Risk Assessment; Risk Factors; RNA; RNA, Messenger; RNA, Ribosomal, 16S; Robotic Surgical Procedures; Running; Rural Population; Saccharomyces cerevisiae; Salpingectomy; Sarcopenia; SARS-CoV-2; Seeds; Semen; Sensitivity and Specificity; Sepsis; Shock, Septic; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Skin Neoplasms; Sleep Apnea, Obstructive; Soil; Spain; Spectrum Analysis, Raman; Sperm Retrieval; Spermatozoa; Spirometry; Staphylococcus aureus; STAT3 Transcription Factor; Stereoisomerism; Sterilization, Tubal; Stroke Volume; Sulfadiazine; Sulfites; Superoxide Dismutase; Surface Plasmon Resonance; tau Proteins; Testis; Testosterone; Thioredoxin-Disulfide Reductase; Thyroid Neoplasms; Thyroidectomy; Trans-Activators; Transcription Factor AP-1; Treatment Outcome; Triazoles; Triclosan; Trifluridine; Tumor Microenvironment; Tumor Necrosis Factor-alpha; United States; Uracil; Vagina; Vegetables; Ventricular Function, Left; Ventricular Pressure; Vibrio cholerae; Vietnam; Virulence; Vital Capacity; Vitrification; Walking; Water; Water Pollutants, Radioactive; Whole Genome Sequencing; Wind; YAP-Signaling Proteins; Zeolites; Zinc Oxide | 2023 |
[Systemic treatment of vitiligo : Balance and current developments].
Topics: alpha-MSH; Animals; Biomarkers; Combined Modality Therapy; Disease Models, Animal; Humans; Immunosuppressive Agents; Interferon-alpha; Janus Kinases; Nitriles; Piperidines; Pyrazoles; Pyrimidines; Pyrroles; Ultraviolet Therapy; Vitiligo | 2017 |
Plexiform Arteriopathy in Rodent Models of Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Disease Progression; Humans; Hypoxia; Indoles; MAP Kinase Signaling System; Mice; Mice, Knockout; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats | 2019 |
Evaluation of lixivaptan in euvolemic and hypervolemic hyponatremia and heart failure treatment.
Topics: Animals; Benzamides; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation; Electrolytes; Heart Failure; Humans; Hyponatremia; Outpatients; Pyrroles; Receptors, Vasopressin; Sodium; Treatment Outcome | 2013 |
Preclinical recapitulation of antiangiogenic drug clinical efficacies using models of early or late stage breast cancer metastatis.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Clinical Trials, Phase III as Topic; Disease Models, Animal; Female; Heterografts; Humans; Indoles; Mice; Mice, Transgenic; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Neoplasm Transplantation; Pyrroles; Species Specificity; Sunitinib; Survival Analysis; Treatment Outcome | 2013 |
Comparative pathophysiology, toxicology, and human cancer risk assessment of pharmaceutical-induced hibernoma.
Topics: Animals; Benzazepines; Carcinogenicity Tests; Disease Models, Animal; Humans; Hydromorphone; Lipoma; Mutagenicity Tests; Neoplasms; Phentolamine; Piperidines; Pyrimidines; Pyrroles; Quinoxalines; Rats; Risk Assessment; Varenicline | 2013 |
Therapeutic targeting of the Jak/STAT pathway.
Topics: Animals; Autoimmune Diseases; Cytokines; Disease Models, Animal; Humans; Janus Kinases; Nitriles; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Pyrroles; Signal Transduction; STAT Transcription Factors | 2014 |
Therapeutic potential of vasopressin-receptor antagonists in heart failure.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Benzazepines; Body Water; Clinical Trials as Topic; Disease Models, Animal; Heart Failure; Homeostasis; Humans; Hyponatremia; Morpholines; Pyrroles; Receptors, Vasopressin; Spiro Compounds; Tolvaptan; Ventricular Remodeling | 2014 |
Current State of Immunosuppression: Past, Present, and Future.
Topics: Abatacept; Alemtuzumab; Animals; Antibodies, Monoclonal, Humanized; Azathioprine; Bone Marrow Transplantation; Calcineurin Inhibitors; Cyclosporine; Disease Models, Animal; Everolimus; Heart Transplantation; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Kidney Transplantation; Lung Transplantation; Mycophenolic Acid; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Sirolimus; Tacrolimus | 2015 |
What is the promise of new antiepileptic drugs in status epilepticus? Focus on brivaracetam, carisbamate, lacosamide, NS-1209, and topiramate.
Topics: Acetamides; Animals; Anticonvulsants; Carbamates; Disease Models, Animal; Fructose; Humans; Lacosamide; Pyrroles; Pyrrolidinones; Rats; Receptors, AMPA; Status Epilepticus; Tetrahydroisoquinolines; Topiramate; Treatment Outcome | 2009 |
Inhibition of JAK kinases in patients with rheumatoid arthritis: scientific rationale and clinical outcomes.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Health Status; Humans; Janus Kinase 3; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome | 2010 |
The effects of antiangiogenic compound SU5416 in a rat model of pulmonary arterial hypertension.
Topics: Angiogenesis Inhibitors; Animals; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Hypertension, Pulmonary; Indoles; Pyrroles; Rats; Receptors, Vascular Endothelial Growth Factor | 2011 |
Targeting angiogenesis in esophagogastric adenocarcinoma.
Topics: Adenocarcinoma; Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzenesulfonates; Bevacizumab; Biomarkers, Tumor; Clinical Trials, Phase III as Topic; Disease Models, Animal; Disease-Free Survival; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Indoles; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; Polymorphism, Genetic; Protein Kinase Inhibitors; Pyridines; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vascular Endothelial Growth Factor; Sorafenib; Sunitinib; Vascular Endothelial Growth Factor A | 2011 |
Heart failure associated with sunitinib: lessons learned from animal models.
Topics: AMP-Activated Protein Kinases; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Cardiotoxins; Disease Models, Animal; Gastrointestinal Stromal Tumors; Heart Failure; Humans; Indoles; Kidney Neoplasms; Mitochondria; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Risk Factors; Signal Transduction; Sunitinib | 2011 |
The pharmacology of CP-154,526, a non-peptide antagonist of the CRH1 receptor: a review.
Topics: Animals; Anxiety; Autonomic Nervous System; Behavior, Animal; Depression; Digestive System; Disease Models, Animal; Drug Evaluation, Preclinical; Genitalia; Haplorhini; Immune System; Mice; Motor Skills; Neurodegenerative Diseases; Neurosecretory Systems; Pyrimidines; Pyrroles; Rats; Receptors, Corticotropin-Releasing Hormone | 2003 |
The pressure is rising.
Topics: Animals; Atorvastatin; Critical Care; Disease Models, Animal; Drug Evaluation, Preclinical; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Pulmonary Embolism; Pyrroles; Rats | 2007 |
Protective effects of ATP-sensitive potassium-channel openers in experimental myocardial ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dihydropyridines; Disease Models, Animal; Dogs; Guanidines; Guinea Pigs; Myocardial Contraction; Myocardial Infarction; Myocardial Ischemia; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Rats; Vasodilator Agents | 1994 |
Potassium channel activator drugs: mechanism of action, pharmacological properties, and therapeutic potential.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cardiovascular System; Central Nervous System; Clinical Trials as Topic; Cromakalim; Disease Models, Animal; Guanidines; Humans; Muscle, Smooth, Vascular; Muscles; Neurons; Niacinamide; Nicorandil; Pancreas; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
Pathogenesis of experimental giant neurofilamentous axonopathies: a unified hypothesis based on chemical modification of neurofilaments.
Topics: Animals; Axonal Transport; Axons; Chickens; Cytoskeleton; Disease Models, Animal; Glyceraldehyde-3-Phosphate Dehydrogenases; Hexanones; Humans; In Vitro Techniques; Intermediate Filament Proteins; Intermediate Filaments; Mice; Nervous System Diseases; Neurofilament Proteins; Nitriles; Phosphorylation; Pyrroles; Rats | 1985 |
3 trial(s) available for pyrroles and Disease Models, Animal
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosphate; Adsorption; Adult; Africa, Eastern; Aged; Air Pollutants; Air Pollution; Air Pollution, Indoor; Alcohol Drinking; Allergens; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Immobilized; Antigen Presentation; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Aptamers, Nucleotide; Asthma; Asthma, Exercise-Induced; Atrophy; Autophagy; Azoospermia; Bacillus cereus; Bacterial Infections; Beclin-1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biofouling; Biological Monitoring; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Blastocyst; Bone Neoplasms; Bone Regeneration; Bronchoconstriction; Burkitt Lymphoma; C9orf72 Protein; Campylobacter; Campylobacter Infections; Campylobacter jejuni; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cardiomyopathies; Caregivers; Carmine; Case-Control Studies; Catalysis; Cattle; Cause of Death; CCAAT-Enhancer-Binding Protein-alpha; CD8-Positive T-Lymphocytes; Cefepime; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Transdifferentiation; Chelating Agents; Chemical and Drug Induced Liver Injury, Chronic; Chemoradiotherapy, Adjuvant; Child; Child, Preschool; China; Chlorquinaldol; Cholangiocarcinoma; Cholera; Chromatin; Clinical Trials as Topic; Cognitive Dysfunction; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Colorimetry; Cooking; Coordination Complexes; COVID-19; Creatinine; CRISPR-Cas Systems; Critical Care; Critical Illness; Cross-Sectional Studies; Cryopreservation; Cryoprotective Agents; Cysteine; Cytokines; Device Removal; Diet; Diet, High-Fat; Diet, Mediterranean; Dietary Supplements; Dimethyl Sulfoxide; Dipeptides; Disease Models, Animal; Dithiothreitol; DNA; DNA Repeat Expansion; DNA, Bacterial; DNA, Complementary; Dopamine; Electrochemical Techniques; Electrodes; Endocannabinoids; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Enzyme-Linked Immunosorbent Assay; Erlotinib Hydrochloride; Escherichia coli; Escherichia coli O157; Esophageal Neoplasms; Esophagitis, Peptic; Ethylene Glycol; Europium; Exanthema; Fallopian Tubes; Feces; Female; Fertilization in Vitro; Fluoresceins; Fluorescent Dyes; Follicle Stimulating Hormone; Follow-Up Studies; Food Microbiology; Forced Expiratory Volume; Forkhead Transcription Factors; Frontotemporal Dementia; G-Quadruplexes; Galactose; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Neoplasms; Gastrointestinal Tract; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genital Neoplasms, Female; Genome-Wide Association Study; Genome, Viral; Genomics; Genotype; Glucose; Glutathione; Glycerol; Gold; Graphite; GTPase-Activating Proteins; Heat-Shock Proteins; Heme Oxygenase-1; Hepacivirus; Hepatitis C; Hepatocytes; Histamine; Histocompatibility Antigens Class II; Hoarseness; Hospice and Palliative Care Nursing; Humans; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydroxybenzoates; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Hysteroscopy; Immunoassay; Indigo Carmine; Inflammation; Inflammatory Bowel Diseases; Insulin Resistance; Intensive Care Units; Interleukin-11; Interleukin-6; Interleukins; Iodine Radioisotopes; Iran; Iridium; Islets of Langerhans; Kinetics; Lactation; Lactobacillus; Lactobacillus plantarum; Lamins; Latin America; Lead; Lectins; Leukopenia; Ligands; Limit of Detection; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Cirrhosis; Liver Neoplasms; Lolium; Luminescent Measurements; Luminol; Lung; Luteinizing Hormone; Macrophages; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Malnutrition; Maltose; Manganese Compounds; Maternal Nutritional Physiological Phenomena; Melatonin; Metabolic Engineering; Metal Nanoparticles; Metallocenes; Metaplasia; Methicillin-Resistant Staphylococcus aureus; Methylation; Mevalonic Acid; Mexico; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Microbiota; MicroRNAs; Milk; Mitomycin; Molecular Diagnostic Techniques; Molecular Docking Simulation; Monte Carlo Method; Moringa oleifera; Multiple Sclerosis; Muscle Strength; Muscle, Skeletal; Nanocomposites; Nanotubes, Carbon; Neoadjuvant Therapy; Neoplasms; Neurodegenerative Diseases; Neurotransmitter Agents; NF-E2-Related Factor 2; Nickel; Nitrogen Dioxide; Non-alcoholic Fatty Liver Disease; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Nucleocapsid Proteins; Nutritional Status; Obesity; Osteogenesis; Osteosarcoma; Oxidation-Reduction; Oxides; Oxygen; Oxyquinoline; Pain; Palliative Care; Pancreatic Neoplasms; Pandemics; Particulate Matter; Peroxidase; Peroxidases; Phagocytosis; Phaseolus; Photothermal Therapy; Point-of-Care Systems; Polyethyleneimine; Polymers; Polymorphism, Single Nucleotide; Polysomnography; Postoperative Complications; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Prevalence; Printing, Three-Dimensional; Probability; Probiotics; Prognosis; Prophages; Prospective Studies; Proteomics; Proto-Oncogene Proteins; Pseudomonas aeruginosa; Pseudomonas putida; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Pyridines; Pyrroles; Quality of Life; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Histamine; Receptors, Histamine H2; Recombinases; Rectal Neoplasms; Reperfusion Injury; Respiration; Respiratory Function Tests; Respiratory Rate; Respiratory Sounds; Retrospective Studies; rho GTP-Binding Proteins; Risk Assessment; Risk Factors; RNA; RNA, Messenger; RNA, Ribosomal, 16S; Robotic Surgical Procedures; Running; Rural Population; Saccharomyces cerevisiae; Salpingectomy; Sarcopenia; SARS-CoV-2; Seeds; Semen; Sensitivity and Specificity; Sepsis; Shock, Septic; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Skin Neoplasms; Sleep Apnea, Obstructive; Soil; Spain; Spectrum Analysis, Raman; Sperm Retrieval; Spermatozoa; Spirometry; Staphylococcus aureus; STAT3 Transcription Factor; Stereoisomerism; Sterilization, Tubal; Stroke Volume; Sulfadiazine; Sulfites; Superoxide Dismutase; Surface Plasmon Resonance; tau Proteins; Testis; Testosterone; Thioredoxin-Disulfide Reductase; Thyroid Neoplasms; Thyroidectomy; Trans-Activators; Transcription Factor AP-1; Treatment Outcome; Triazoles; Triclosan; Trifluridine; Tumor Microenvironment; Tumor Necrosis Factor-alpha; United States; Uracil; Vagina; Vegetables; Ventricular Function, Left; Ventricular Pressure; Vibrio cholerae; Vietnam; Virulence; Vital Capacity; Vitrification; Walking; Water; Water Pollutants, Radioactive; Whole Genome Sequencing; Wind; YAP-Signaling Proteins; Zeolites; Zinc Oxide | 2023 |
Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Atorvastatin; Biomarkers; Cardiomegaly; Cells, Cultured; Cholesterol; Cholesterol, LDL; Coronary Vessels; Cross-Over Studies; Cytoskeletal Proteins; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Guanine Nucleotide Exchange Factors; Heptanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Japan; Male; Mice; Mice, Knockout; Neuropeptides; Oxidative Stress; Phosphatidylinositol 3-Kinase; Pravastatin; Proto-Oncogene Proteins c-akt; Pyrroles; Quinolines; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; RNA Interference; Signal Transduction; Transfection | 2013 |
Heterogeneity in lung (18)FDG uptake in pulmonary arterial hypertension: potential of dynamic (18)FDG positron emission tomography with kinetic analysis as a bridging biomarker for pulmonary vascular remodeling targeted treatments.
Topics: Adult; Aged; Animals; Benzamides; Cell Division; Dichloroacetic Acid; Disease Models, Animal; Drug Monitoring; Familial Primary Pulmonary Hypertension; Female; Fibroblasts; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Gene Expression Profiling; Glycolysis; Humans; Hypertension, Pulmonary; Imatinib Mesylate; Indoles; Lung; Male; Middle Aged; Monocrotaline; Piperazines; Positron-Emission Tomography; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Sunitinib; Young Adult | 2013 |
827 other study(ies) available for pyrroles and Disease Models, Animal
| Article | Year |
|---|---|
Treprostinil palmitil inhibits the hemodynamic and histopathological changes in the pulmonary vasculature and heart in an animal model of pulmonary arterial hypertension.
Topics: Administration, Inhalation; Administration, Oral; Animals; Collagen; Disease Models, Animal; Epoprostenol; Heart; Hemodynamics; Hypoxia; Indoles; Male; Myocardium; Phosphodiesterase 5 Inhibitors; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Sildenafil Citrate; Vascular Remodeling; Vasodilator Agents | 2022 |
Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416/hypoxia model of pulmonary hypertension.
Topics: Animals; Diaphragm; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Interleukin-1 Receptor-Like 1 Protein; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Mitochondrial Diseases; Muscle Contraction; Protein Kinase Inhibitors; Pulmonary Arterial Hypertension; Pyrroles | 2022 |
Riociguat can ameliorate bronchopulmonary dysplasia in the SU5416 induced rat experimental model.
Topics: Animals; Animals, Newborn; Bronchopulmonary Dysplasia; Disease Models, Animal; Humans; Hyperoxia; Indoles; Infant, Newborn; Lung; Models, Theoretical; Pyrazoles; Pyrimidines; Pyrroles; Rats | 2021 |
Right predominant electrical remodeling in a pure model of pulmonary hypertension promotes reentrant arrhythmias.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Disease Models, Animal; Hypertension, Pulmonary; Indoles; Magnetic Resonance Imaging; Male; Pneumonectomy; Pyrroles; Rats; Rats, Sprague-Dawley; Thoracotomy; Ventricular Remodeling | 2022 |
Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Humans; Lung Neoplasms; Mice; Protein-Arginine N-Methyltransferases; Pyrimidines; Pyrroles | 2021 |
Saroglitazar improved hepatic steatosis and fibrosis by modulating inflammatory cytokines and adiponectin in an animal model of non-alcoholic steatohepatitis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cytokines; Disease Models, Animal; Gene Expression Regulation; Liver; Liver Cirrhosis; Male; Non-alcoholic Fatty Liver Disease; Phenylpropionates; PPAR alpha; PPAR gamma; Pyrroles; Rats, Wistar | 2021 |
Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia.
Topics: Animals; Benzamides; Butyric Acid; Cachexia; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Female; Heart Diseases; Histone Deacetylase Inhibitors; Hydroxamic Acids; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasms; Pyridines; Pyrroles | 2022 |
Myosin 1f-mediated activation of microglia contributes to the photoreceptor degeneration in a mouse model of retinal detachment.
Topics: Aminopyridines; Animals; Calcium-Binding Proteins; Cell Death; Cell Line; Disease Models, Animal; Gene Expression Profiling; Light; MAP Kinase Signaling System; Mice, Knockout; Microfilament Proteins; Microglia; Models, Biological; Myosin Type I; Myosins; Photoreceptor Cells, Vertebrate; Proto-Oncogene Proteins c-akt; Pyrroles; Retinal Degeneration; Retinal Detachment; Up-Regulation | 2021 |
TRPV4 inhibitor HC067047 produces antidepressant-like effect in LPS-induced depression mouse model.
Topics: Animals; Antidepressive Agents; Astrocytes; Depression; Disease Models, Animal; Doublecortin Protein; Hippocampus; Inflammasomes; Lipopolysaccharides; Male; Mice, Inbred C57BL; Microglia; Neurogenesis; Neuroinflammatory Diseases; NLR Family, Pyrin Domain-Containing 3 Protein; Pyrroles; TRPV Cation Channels | 2021 |
Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 Reduces Vasogenic Edema after Traumatic Brain Injury in Mice.
Topics: Animals; Astrocytes; Blood-Brain Barrier; Brain Edema; Brain Injuries, Traumatic; Disease Models, Animal; Male; Matrix Metalloproteinase 9; Mice; Morpholines; Pyrroles; Real-Time Polymerase Chain Reaction; Sulfonamides; TRPV Cation Channels; Vascular Endothelial Growth Factor A | 2021 |
The local wound environment is a key determinant of the outcome of TGFβ signaling on the fibrotic response of CD44
Topics: Actins; Animals; Blotting, Western; Capsule Opacification; Cataract Extraction; Cell Proliferation; Chick Embryo; Collagen Type I; Disease Models, Animal; Fibronectins; Fibrosis; Hyaluronan Receptors; Imidazoles; Integrin alphaVbeta3; Microscopy, Fluorescence; Myofibroblasts; Posterior Capsule of the Lens; Postoperative Complications; Pyrazoles; Pyrroles; Quinoxalines; Receptor, Transforming Growth Factor-beta Type I; Signal Transduction; Transforming Growth Factor beta; Wound Healing | 2021 |
Andrographolide Attenuates Established Pulmonary Hypertension via Rescue of Vascular Remodeling.
Topics: Animals; Anti-Inflammatory Agents; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Disease Models, Animal; Diterpenes; Female; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Indoles; Male; Mice; Primary Cell Culture; Pyrroles; Signal Transduction; Vascular Remodeling | 2021 |
Microglial replacement in the aged brain restricts neuroinflammation following intracerebral hemorrhage.
Topics: Aging; Aminopyridines; Animals; Blood-Brain Barrier; Brain; Brain Injuries; Cell Death; Cerebral Hemorrhage; Chemotaxis, Leukocyte; Disease Models, Animal; Mice; Microglia; Neuroinflammatory Diseases; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor | 2022 |
10Z‑Hymenialdisine inhibits angiogenesis by suppressing NF‑κB activation in pancreatic cancer cell lines.
Topics: Angiogenesis Inhibitors; Animals; Azepines; Cell Line, Tumor; Disease Models, Animal; Humans; Mice; Neovascularization, Pathologic; NF-kappa B; Pancreatic Neoplasms; Pyrroles | 2022 |
Mineralocorticoid receptor antagonist treatment of established pulmonary arterial hypertension improves interventricular dependence in the SU5416-hypoxia rat model.
Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Mineralocorticoid Receptor Antagonists; Pulmonary Arterial Hypertension; Pyrroles; Rats; Ventricular Dysfunction, Right | 2022 |
VX-11e protects articular cartilage and subchondral bone in osteoarthritis by inhibiting the RIP1/RIP3/MLKL and MAPK signaling pathways.
Topics: Animals; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Mice; Molecular Docking Simulation; Osteoarthritis; Protein Kinases; Pyrimidines; Pyrroles; Signal Transduction | 2022 |
Corticotropin-Releasing Factor Aggravates Ischemic Stroke Injury by the Inflammatory Activation of Microglia.
Topics: Animals; Corticotropin-Releasing Hormone; Disease Models, Animal; Inflammation; Ischemic Stroke; Male; Mice; Microglia; Neurons; NF-kappa B; Peptide Fragments; Peptides, Cyclic; Phosphorylation; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone | 2022 |
Peripheral administration of the Class-IIa HDAC inhibitor MC1568 partially protects against nigrostriatal neurodegeneration in the striatal 6-OHDA rat model of Parkinson's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Neurodegenerative Diseases; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Pyrroles; Rats; Substantia Nigra | 2022 |
PD-1 Targeted Nanoparticles Inhibit Activated T Cells and Alleviate Autoimmunity via Suppression of Cellular Energy Metabolism Mediated by PKM2.
Topics: Animals; Autoimmune Diseases; Autoimmunity; Disease Models, Animal; Energy Metabolism; Mice; Mice, Inbred C57BL; Nanoparticles; Programmed Cell Death 1 Receptor; Pyridazines; Pyrroles; Pyruvate Kinase; Th1 Cells; Th17 Cells | 2022 |
Early posttraumatic CSF1R inhibition via PLX3397 leads to time- and sex-dependent effects on inflammation and neuronal maintenance after traumatic brain injury in mice.
Topics: Aminopyridines; Animals; Brain Injuries, Traumatic; Disease Models, Animal; Female; Inflammation; Macrophage Colony-Stimulating Factor; Male; Mice; Mice, Inbred C57BL; Microglia; Oxidoreductases; Pyrroles; Receptors, Colony-Stimulating Factor; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor | 2022 |
New Degradable Semiconducting Polymers for Photoacoustic Imaging of λ-Carrageenan-Induced Arthritis Mouse Model.
Topics: Animals; Arthritis; Carrageenan; Contrast Media; Disease Models, Animal; Ketones; Mice; Nanoparticles; Photoacoustic Techniques; Polymers; Pyrroles; Spectroscopy, Near-Infrared | 2022 |
Efficacy of futibatinib, an irreversible fibroblast growth factor receptor inhibitor, in FGFR-altered breast cancer.
Topics: Animals; Breast Neoplasms; Disease Models, Animal; Female; Humans; Pyrazoles; Pyrimidines; Pyrroles; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor | 2023 |
Effects of novel pyrrolomycin MP1 in MYCN amplified chemoresistant neuroblastoma cell lines alone and combined with temsirolimus.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers; Cell Cycle; Cell Line, Tumor; Disease Models, Animal; Drug Interactions; Drug Resistance, Neoplasm; Gene Amplification; Humans; Mice; Molecular Structure; N-Myc Proto-Oncogene Protein; Neuroblastoma; Pyrroles; Sirolimus; Spectrum Analysis; Xenograft Model Antitumor Assays | 2019 |
Targeting castration-resistant prostate cancer with androgen receptor antisense oligonucleotide therapy.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotides, Antisense; Phosphatidylinositol 3-Kinases; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptors, Androgen; Signal Transduction; Transcriptome | 2019 |
Discovery of Pyrrolo[2,3-
Topics: Administration, Oral; Animals; Chagas Disease; Crystallography, X-Ray; Disease Models, Animal; Male; Mice; Molecular Conformation; Nucleosides; Pyridines; Pyrroles; Structure-Activity Relationship; Survival Rate; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Tolerogenic dendritic cell transfer ameliorates systemic lupus erythematosus in mice.
Topics: Animals; Antibodies, Antinuclear; Cell Differentiation; Cells, Cultured; Dendritic Cells; Dexamethasone; Disease Models, Animal; Humans; Immune Tolerance; Immunotherapy, Adoptive; Kidney; Lupus Erythematosus, Systemic; Lymphocyte Activation; Mice; Mice, Inbred MRL lpr; Pyrazines; Pyrroles; Rosiglitazone; T-Lymphocytes, Regulatory | 2019 |
Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclohexanes; Disease Models, Animal; Humans; Magnetic Resonance Imaging; Mice; Neoplasms; Positron-Emission Tomography; Pyrroles; Thiazoles; Xenograft Model Antitumor Assays | 2019 |
Modulation of smoke-induced DNA and microRNA alterations in mouse lung by licofelone, a triple COX-1, COX-2 and 5-LOX inhibitor.
Topics: Animals; Anticarcinogenic Agents; Arachidonate 5-Lipoxygenase; Carcinogenesis; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; DNA Adducts; DNA Damage; Drug Administration Schedule; Female; Humans; Inflammation; Lung; Lung Neoplasms; Male; Membrane Proteins; Mice; MicroRNAs; Pyrroles; Time Factors; Tobacco Smoke Pollution; Toxicity Tests, Subchronic | 2020 |
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model.
Topics: Alzheimer Disease; Aminopyridines; Animals; Apolipoproteins E; Brain; Dietary Supplements; Disease Models, Animal; Humans; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microglia; Neurodegenerative Diseases; Pyrroles; tau Proteins; Tauopathies | 2019 |
The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders.
Topics: Animals; Cognitive Dysfunction; Disease Models, Animal; Female; Male; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Microglia; Mitogen-Activated Protein Kinase Kinase Kinase 11; Neurocognitive Disorders; Perioperative Care; Pyridines; Pyrroles | 2019 |
Role of Elevated Thrombospondin-1 in Kainic Acid-Induced Status Epilepticus.
Topics: Animals; Chondroitin Sulfates; Disease Models, Animal; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Imidazoles; Isoquinolines; Kainic Acid; Male; Protein Kinase Inhibitors; Pyridazines; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad2 Protein; Smad3 Protein; Status Epilepticus; Thrombospondin 1; Transforming Growth Factor beta1 | 2020 |
Systemic thrombin inhibition ameliorates seizures in a mouse model of pilocarpine-induced status epilepticus.
Topics: Animals; Anticoagulants; Disease Models, Animal; Hippocampus; Male; Mice; Pilocarpine; Pyrroles; Quinazolines; Receptor, PAR-1; Status Epilepticus; Thrombin | 2019 |
S-Nitrosoglutathione Mimics the Beneficial Activity of Endothelial Nitric Oxide Synthase-Derived Nitric Oxide in a Mouse Model of Stroke.
Topics: Alcohol Dehydrogenase; Animals; Behavior, Animal; Benzamides; Brain; Brain Edema; Disease Models, Animal; Enzyme Inhibitors; Infarction, Middle Cerebral Artery; Male; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrroles; S-Nitrosoglutathione | 2019 |
Inhibition of JAK-STAT and NF-κB signalling systems could be a novel therapeutic target against insulin resistance and type 2 diabetes.
Topics: Animals; Aspirin; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Interleukin-6; Janus Kinases; Male; NF-kappa B; Piperidines; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Serum Amyloid A Protein; Signal Transduction; STAT Transcription Factors; Tumor Necrosis Factor-alpha | 2019 |
Gastric acid inhibitor aggravates indomethacin-induced small intestinal injury via reducing Lactobacillus johnsonii.
Topics: Animals; Disease Models, Animal; Dysbiosis; Fecal Microbiota Transplantation; High-Throughput Nucleotide Sequencing; Humans; Indomethacin; Injections, Intraperitoneal; Intestine, Small; Lactobacillus johnsonii; Male; Mice; Mice, Inbred C57BL; Proton Pump Inhibitors; Pyrroles; Rabeprazole; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Sulfonamides | 2019 |
An Injectable Conductive Three-Dimensional Elastic Network by Tangled Surgical-Suture Spring for Heart Repair.
Topics: Animals; Cell Adhesion; Cell Differentiation; Cell Survival; Dihydroxyphenylalanine; Disease Models, Animal; Elasticity; Electric Conductivity; Electrochemistry; Heart Function Tests; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Injections; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Neovascularization, Physiologic; Polyglutamic Acid; Polymers; Pyrroles; Rats, Sprague-Dawley; Sutures; Wound Healing | 2019 |
The effects of dopamine D4 receptor ligands on operant alcohol self-administration and cue- and stress-induced reinstatement in rats.
Topics: Alcoholism; Animals; Behavior, Animal; Benzamides; Conditioning, Operant; Cues; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Antagonists; Drug-Seeking Behavior; Ethanol; Extinction, Psychological; Humans; Male; Piperazines; Pyridines; Pyrroles; Rats; Receptors, Dopamine D4; Self Administration; Stress, Psychological | 2020 |
Alterations of voluntary behavior in the course of disease progress and pharmacotherapy in mice with collagen-induced arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Disease Progression; Humans; Joints; Male; Mice, Inbred DBA; Motor Activity; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Synovitis; Temperature | 2019 |
Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease.
Topics: Aminopyridines; Animals; Astrocytes; Chondroitin Sulfate Proteoglycans; Cytokines; Disease Models, Animal; Down-Regulation; Extracellular Matrix; Hand Strength; Humans; Huntingtin Protein; Huntington Disease; Inflammation; Mice; Mice, Transgenic; Microglia; Neostriatum; Neurites; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Recognition, Psychology; RNA, Messenger; Synapses; Transcriptome | 2020 |
A novel murine model for assessing fetal and birth outcomes following transgestational maternal malaria infection.
Topics: Animals; Cell Survival; Chromosome Pairing; Disease Models, Animal; Female; Finite Element Analysis; Malaria; Malaria, Falciparum; Mice; Nerve Regeneration; Polymers; Pregnancy; Pregnancy Complications, Parasitic; Pyrroles; Tissue Scaffolds | 2019 |
Janus kinase inhibitor delgocitinib suppresses pruritus and nerve elongation in an atopic dermatitis murine model.
Topics: Administration, Cutaneous; Animals; Antipruritics; Dermatitis, Atopic; Disease Models, Animal; Female; Humans; Janus Kinase Inhibitors; Male; Mice; Pruritus; Pyrroles; Skin | 2020 |
Short treatment with antalarmin alters adrenal gland receptors in the rat model of endometriosis.
Topics: Adrenal Glands; Animals; Disease Models, Animal; Endometriosis; Female; Pituitary-Adrenal System; Pyrimidines; Pyrroles; Rats; Receptors, Corticotropin-Releasing Hormone; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; RNA, Messenger; Up-Regulation | 2020 |
Microglial activation increases cocaine self-administration following adolescent nicotine exposure.
Topics: Aminopyridines; Animals; Chemokine CX3CL1; Cocaine; Disease Models, Animal; Drug-Seeking Behavior; Electronic Nicotine Delivery Systems; Female; Gene Expression Regulation; Male; Microglia; Minocycline; Nicotine; Phenotype; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Reinforcement, Psychology; Reward; Self Administration; Synaptophysin | 2020 |
Synthetic 4-Hydroxy Auxarconjugatin B, a Novel Autophagy Inducer, Attenuates Gouty Inflammation by Inhibiting the NLRP3 Inflammasome.
Topics: Animals; Arthritis, Gouty; Autophagy; CARD Signaling Adaptor Proteins; Cell Line; Disease Models, Animal; Humans; Inflammasomes; Inflammation; Lipopolysaccharides; Lysosomes; Macrophages; Male; Mice, Inbred C57BL; Mitochondria; Models, Biological; NLR Family, Pyrin Domain-Containing 3 Protein; Organelle Biogenesis; Protein Multimerization; Pyrroles; Sirtuin 1 | 2020 |
Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis.
Topics: Animals; Apoptosis; Blindness; Cell Line; Disease Models, Animal; Enzyme Activators; Glycolysis; Humans; Intravitreal Injections; Male; Mice; Mice, Knockout; Photoreceptor Cells; Protein Isoforms; Pyridazines; Pyrroles; Pyruvate Kinase; Rabbits; Rats; Retinal Diseases | 2020 |
Potential synergistic effects of novel hematopoietic prostaglandin D synthase inhibitor TAS-205 and different types of anti-allergic medicine on nasal obstruction in a Guinea pig model of experimental allergic rhinitis.
Topics: Acetates; Animals; Anti-Allergic Agents; Cell Line; Cyclopropanes; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Guinea Pigs; Humans; Intramolecular Oxidoreductases; Lipocalins; Male; Morpholines; Nasal Mucosa; Nasal Obstruction; Ovalbumin; Piperidines; Prostaglandin D2; Pyrroles; Quality of Life; Quinolines; Rats; Rhinitis, Allergic; Sulfides; Terfenadine | 2020 |
Circumventing AKT-Associated Radioresistance in Oral Cancer by Novel Nanoparticle-Encapsulated Capivasertib.
Topics: Animals; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred NOD; Mouth Neoplasms; Nanoparticles; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Xenograft Model Antitumor Assays | 2020 |
Alpha 7 nicotinic receptor agonist and positive allosteric modulators improved social and molecular deficits of MK-801 model of schizophrenia in rats.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Avoidance Learning; Clozapine; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Dizocilpine Maleate; Glycogen Synthase Kinase 3 beta; Isoxazoles; Male; Phenylurea Compounds; Prefrontal Cortex; Proto-Oncogene Proteins c-akt; Pyridazines; Pyrroles; Rats; Rats, Wistar; Schizophrenia; Signal Transduction; Social Interaction; Treatment Outcome | 2020 |
Paeoniflorin Ameliorates Chronic Hypoxia/SU5416-Induced Pulmonary Arterial Hypertension by Inhibiting Endothelial-to-Mesenchymal Transition.
Topics: Animals; Cells, Cultured; Chronic Disease; Disease Models, Animal; Endothelial Cells; Epithelial-Mesenchymal Transition; Glucosides; Humans; Hypoxia; Indoles; Injections, Subcutaneous; Male; Monoterpenes; Oxygen; Pulmonary Arterial Hypertension; Pyrroles; Rats; Rats, Sprague-Dawley | 2020 |
Puerarin inhibits hepatocellular carcinoma invasion and metastasis through miR-21-mediated PTEN/AKT signaling to suppress the epithelial-mesenchymal transition.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Disease Models, Animal; Drug Screening Assays, Antitumor; Epithelial-Mesenchymal Transition; Isoflavones; Liver Neoplasms; Male; MicroRNAs; Neoplasm Invasiveness; PTEN Phosphohydrolase; Pyrroles | 2020 |
Fibrosis growth factor 23 is a promoting factor for cardiac fibrosis in the presence of transforming growth factor-β1.
Topics: Actins; Animals; Cells, Cultured; Disease Models, Animal; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibrosis; Heart Diseases; Male; Myocytes, Cardiac; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor, Fibroblast Growth Factor, Type 1; Transforming Growth Factor beta1; Up-Regulation | 2020 |
Targeting GSNOR for functional recovery in a middle-aged mouse model of stroke.
Topics: Aging; Alcohol Dehydrogenase; Animals; Benzamides; Disease Models, Animal; Drug Delivery Systems; Male; Mice; Mice, Inbred C57BL; Pyrroles; Recovery of Function; Stroke | 2020 |
A novel rat model of pulmonary hypertension induced by mono treatment with SU5416.
Topics: Animals; Blood Pressure; Cardiac Output; Disease Models, Animal; Heart; Hypertension, Pulmonary; Indoles; Lung; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Vascular Resistance | 2020 |
Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice.
Topics: Animals; Collagen Type III; Cytokines; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibrosis; HEK293 Cells; Humans; Hypertension; Hypertrophy, Left Ventricular; Inflammation Mediators; Macrophages; Male; Mice, Inbred C57BL; Mice, Transgenic; Myocardium; Pyrroles; Quinazolines; Receptor, PAR-1; Renin; Signal Transduction; Transforming Growth Factor beta1; Up-Regulation; Ventricular Function, Left; Ventricular Remodeling | 2020 |
Endothelial HIF-2α as a Key Endogenous Mediator Preventing Emphysema.
Topics: Angiogenesis Inhibitors; Animals; Basic Helix-Loop-Helix Transcription Factors; Deferoxamine; Disease Models, Animal; Endothelial Cells; Hepatocyte Growth Factor; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Iron Chelating Agents; Lung; Mice; Mice, Knockout; Microvessels; Pericytes; Pulmonary Circulation; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Pyrroles; Smoke | 2020 |
The PPAR α/γ Agonist Saroglitazar Improves Insulin Resistance and Steatohepatitis in a Diet Induced Animal Model of Nonalcoholic Fatty Liver Disease.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Dyslipidemias; Endoplasmic Reticulum Stress; Gene Expression Profiling; Insulin Resistance; Liver; Liver Cirrhosis; Metabolomics; Non-alcoholic Fatty Liver Disease; Phenylpropionates; PPAR alpha; PPAR gamma; Pyrroles; Signal Transduction | 2020 |
Induction and Characterization of Pulmonary Hypertension in Mice using the Hypoxia/SU5416 Model.
Topics: Animals; Cell Hypoxia; Disease Models, Animal; Fibrosis; Heart Ventricles; Humans; Hydrogen-Ion Concentration; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indoles; Male; Mice; Pulmonary Artery; Pulmonary Circulation; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Remodeling; Ventricular Remodeling | 2020 |
Recovery of motor function after traumatic spinal cord injury by using plasma-synthesized polypyrrole/iodine application in combination with a mixed rehabilitation scheme.
Topics: Animals; Argon Plasma Coagulation; Biocompatible Materials; Chemical Precipitation; Combined Modality Therapy; Disease Models, Animal; Environment Design; Exercise Therapy; Female; Injections, Spinal; Iodine; Laminectomy; Lasers, Gas; Motor Activity; Nerve Regeneration; Polymers; Pyrroles; Rats; Rats, Long-Evans; Recovery of Function; Spinal Cord Injuries; Spinal Cord Regeneration; Swimming | 2020 |
Ubrogepant does not induce latent sensitization in a preclinical model of medication overuse headache.
Topics: Analgesics; Animals; Central Nervous System Sensitization; Disease Models, Animal; Female; Headache Disorders, Secondary; Hyperalgesia; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Sumatriptan | 2020 |
Periostin: A Potential Therapeutic Target For Pulmonary Hypertension?
Topics: Animals; Biomarkers; Bone Morphogenetic Protein Receptors, Type II; Cell Adhesion Molecules; Cell Hypoxia; Cell Movement; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Endothelin-1; Humans; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Membrane Glycoproteins; Mice; Myocytes, Smooth Muscle; Protein-Tyrosine Kinases; Pulmonary Artery; Pyrroles; Receptor, trkB; Vascular Endothelial Growth Factor A | 2020 |
Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice.
Topics: Aging; Alzheimer Disease; Aminopyridines; Amyloid; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Hippocampus; Humans; Macrophage Colony-Stimulating Factor; Mice; Mice, Transgenic; Pyrroles; Receptors, Colony-Stimulating Factor; Signal Transduction | 2020 |
Inhibition of the Extracellular Signal-Regulated Kinase/Ribosomal S6 Kinase Cascade Limits Chlamydia trachomatis Infection.
Topics: Aminopyridines; Animals; Chlamydia Infections; Chlamydia trachomatis; Chlorocebus aethiops; Disease Models, Animal; Female; Gene Knockdown Techniques; HeLa Cells; Host-Pathogen Interactions; Humans; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Targeted Therapy; Protein Kinase Inhibitors; Pyrroles; Ribosomal Protein S6 Kinases, 90-kDa; Vero Cells | 2021 |
TRPV4 antagonists ameliorate ventriculomegaly in a rat model of hydrocephalus.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Hydrocephalus; Morpholines; Nervous System Malformations; Pyrroles; Rats; TRPV Cation Channels | 2020 |
Lack of dopamine D4 receptor participation in mouse hyperdopaminergic locomotor response.
Topics: Amphetamine-Related Disorders; Animals; Antipsychotic Agents; Behavior, Animal; Central Nervous System Sensitization; Clozapine; Disease Models, Animal; Dopamine Agents; Locomotion; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Transgenic; Psychotic Disorders; Pyridines; Pyrroles; Receptors, Dopamine D4 | 2021 |
The effect of microglial ablation and mesenchymal stem cell transplantation on a cuprizone-induced demyelination model.
Topics: Aminopyridines; Animals; Behavior, Animal; Biomarkers; Calcium-Binding Proteins; Chemokine CX3CL1; Corpus Callosum; Cuprizone; CX3C Chemokine Receptor 1; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Injections, Intraventricular; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Myelin Sheath; Pyrroles | 2021 |
α7 nicotinic receptor agonist and positive allosteric modulators differently improved schizophrenia-like cognitive deficits in male rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Behavior, Animal; Cognitive Dysfunction; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Isoxazoles; Male; Nicotinic Agonists; Phenylurea Compounds; Pyridazines; Pyrroles; Rats; Rats, Wistar; Recognition, Psychology; Schizophrenia | 2021 |
SIS3, a good candidate for the reverse of type 2 diabetes mellitus in mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Glucose Tolerance Test; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Pyridines; Pyrroles | 2021 |
Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome.
Topics: Adult; Age Factors; Aminopyridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cognition; Disease Models, Animal; Down Syndrome; Female; Hippocampus; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Pyrroles | 2020 |
The selective PGI2 receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetamides; Animals; Cell Proliferation; Collagen Type I; Disease Models, Animal; Heart Ventricles; Hemodynamics; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Lung; Male; Pulmonary Arterial Hypertension; Pyrazines; Pyrroles; Rats, Sprague-Dawley; Receptors, Epoprostenol; Systole; Vascular Remodeling | 2020 |
Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice.
Topics: Aminopyridines; Animals; Brain; Disease Models, Animal; Female; Macrophages; Male; Mice; Microglia; Nerve Degeneration; Neuronal Ceroid-Lipofuscinoses; Neurons; Pyrroles; Retina; Sex Factors; T-Lymphocytes; Tomography, Optical Coherence | 2020 |
Local Targeting of Lung-Tumor-Associated Macrophages with Pulmonary Delivery of a CSF-1R Inhibitor for the Treatment of Breast Cancer Lung Metastases.
Topics: Administration, Inhalation; Administration, Intravenous; Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Lung Neoplasms; Mice; Paclitaxel; Phosphorylation; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Tumor Microenvironment; Tumor-Associated Macrophages | 2020 |
Increased MAO-A Activity Promotes Progression of Pulmonary Arterial Hypertension.
Topics: Animals; Clorgyline; Disease Models, Animal; Disease Progression; Heart Ventricles; Humans; Hypertrophy, Right Ventricular; Indoles; Monoamine Oxidase; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats; Vascular Remodeling; Vascular Stiffness; Vasodilation | 2021 |
Effect of SIS3 on Extracellular Matrix Remodeling and Repair in a Lipopolysaccharide-Induced ARDS Rat Model.
Topics: Animals; Biomarkers; Collagen; Disease Models, Animal; Extracellular Matrix; Gene Expression; Isoquinolines; Lipopolysaccharides; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neutrophils; Pyridines; Pyrroles; Rats; Receptor for Advanced Glycation End Products; Respiratory Distress Syndrome; Smad3 Protein; Transforming Growth Factor beta1 | 2020 |
A novel approach for monitoring TGF-β signaling in vivo in colon cancer.
Topics: Animals; Benzamides; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Dioxoles; Disease Models, Animal; Humans; Mice; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta | 2021 |
Moderate oxidative stress promotes epithelial-mesenchymal transition in the lens epithelial cells via the TGF-β/Smad and Wnt/β-catenin pathways.
Topics: Animals; Antioxidants; beta Catenin; Capsule Opacification; Cataract; Cell Proliferation; Cell Survival; Disease Models, Animal; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Lens, Crystalline; Mice; Oxidative Stress; Oxygen; Pyrazoles; Pyrroles; Swine; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tropicamide; Wnt Signaling Pathway | 2021 |
Identification of Celastrol as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension and Right Ventricular Failure Through Suppression of Bsg (Basigin)/CyPA (Cyclophilin A).
Topics: Animals; Antihypertensive Agents; Basigin; Cyclophilin A; Disease Models, Animal; Humans; Hypoxia; Indoles; Mice; Mice, Transgenic; Myocytes, Cardiac; Pentacyclic Triterpenes; Pulmonary Arterial Hypertension; Pyrroles; Rats; Triterpenes; Ventricular Dysfunction, Right | 2021 |
Evaluation of right coronary vascular dysfunction in severe pulmonary hypertensive rats using synchrotron radiation microangiography.
Topics: Animals; Antihypertensive Agents; Coronary Angiography; Coronary Vessels; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Monocrotaline; Predictive Value of Tests; Pulmonary Arterial Hypertension; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Severity of Illness Index; Sulfonamides; Synchrotrons; Vasodilation; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2021 |
Transcriptomic Analysis of Right Ventricular Remodeling in Two Rat Models of Pulmonary Hypertension: Identification and Validation of Epithelial-to-Mesenchymal Transition in Human Right Ventricular Failure.
Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Epithelial-Mesenchymal Transition; Female; Gene Expression Profiling; Heart Failure; Heart Ventricles; Humans; Hypoxia; Indoles; Male; Middle Aged; Monocrotaline; Pulmonary Arterial Hypertension; Pyrroles; Rats; Real-Time Polymerase Chain Reaction; RNA-Seq; Transcriptome; Ventricular Dysfunction, Right; Ventricular Remodeling | 2021 |
Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Gene Rearrangement; Histone-Lysine N-Methyltransferase; Humans; Immunohistochemistry; Mice; Mice, Knockout; Myeloid-Lymphoid Leukemia Protein; Pyrimidines; Pyrroles; Steroids; Xenograft Model Antitumor Assays | 2021 |
Cell Tracking Suggests Pathophysiological and Therapeutic Role of Bone Marrow Cells in Sugen5416/Hypoxia Rat Model of Pulmonary Arterial Hypertension.
Topics: Angiogenesis Inhibitors; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Tracking; Disease Models, Animal; Female; Hypoxia; Indoles; Lung; Male; Neointima; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats; Transplantation Chimera; Vascular Remodeling | 2021 |
CM082, a novel VEGF receptor tyrosine kinase inhibitor, can inhibit angiogenesis in vitro and in vivo.
Topics: Angiogenesis Inhibitors; Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Hyperoxia; Indoles; Mice, Inbred C57BL; Neovascularization, Physiologic; Protein Kinase Inhibitors; Pyrroles; Pyrrolidines; Retinal Neovascularization; Retinopathy of Prematurity; Signal Transduction; Vascular Endothelial Growth Factor Receptor-2 | 2021 |
Protective effects of the imidazoline-like drug lnp599 in a marmoset model of obesity-induced metabolic disorders.
Topics: Aniline Compounds; Animals; Body Weight; Callithrix; Disease Models, Animal; Imidazolines; Male; Metabolic Diseases; Obesity; Protective Agents; Pyrroles | 2021 |
Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and increases glial fibrillary acidic protein levels, yet has minimal impact on other disease phenotypes.
Topics: Alexander Disease; Aminopyridines; Animals; Disease Models, Animal; Glial Fibrillary Acidic Protein; Macrophages; Mice; Mice, Inbred C57BL; Phenotype; Pyrroles | 2021 |
Immunomodulation Therapy Using Tolerogenic Macrophages in a Rodent Model of Pulmonary Hypertension.
Topics: Animals; Disease Models, Animal; Gene Expression Profiling; Humans; Hypertension, Pulmonary; Immune Tolerance; Immunomodulation; Immunotherapy; Indoles; Lung; Macrophages; Male; Nerve Tissue Proteins; Potassium Channels, Tandem Pore Domain; Protein Kinase Inhibitors; Pyrroles; Rats, Nude; Rodentia; Stroke Volume; Tomography, Emission-Computed, Single-Photon | 2021 |
Preclinical Investigation of Trifluoperazine as a Novel Therapeutic Agent for the Treatment of Pulmonary Arterial Hypertension.
Topics: Animals; Antipsychotic Agents; Cardiovascular Agents; Cell Proliferation; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Repositioning; Female; Forkhead Box Protein O3; Gene Expression Regulation; Hemodynamics; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Survivin; Trifluoperazine | 2021 |
Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Disease Models, Animal; Docosahexaenoic Acids; Gene Expression Regulation; Insulin-Like Growth Factor I; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocytes, Cardiac; Nuclear Receptor Subfamily 1, Group F, Member 1; Paracrine Communication; Phosphatidylinositol 3-Kinases; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Rats; Ribonucleosides; Signal Transduction; Sulfonamides; Thiophenes; Wortmannin | 2021 |
Effect of CSF1R inhibitor on glial cells population and remyelination in the cuprizone model.
Topics: Aminopyridines; Animals; Cuprizone; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Neuroglia; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Remyelination | 2021 |
Partial depletion and repopulation of microglia have different effects in the acute MPTP mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aminopyridines; Animals; Behavior, Animal; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Dopaminergic Neurons; Inflammation Mediators; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Microglia; MPTP Poisoning; Neuroprotective Agents; Pyrroles; Receptors, Immunologic | 2021 |
PI3Kα inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8
Topics: Animals; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Fatty Acids; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Nude; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Pyrroles; Random Allocation; Tumor Microenvironment | 2021 |
Antiviral activity of PHA767491 against human herpes simplex virus in vitro and in vivo.
Topics: Animals; Antiviral Agents; Cell Line; Disease Models, Animal; Drug Resistance, Viral; Gene Expression Regulation, Viral; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Mice; Microbial Sensitivity Tests; Piperidones; Pyrroles; Viral Proteins; Virus Replication | 2017 |
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Drug Resistance; Enzyme Inhibitors; Heterografts; Humans; Indoles; Mice, Nude; Phenylurea Compounds; Protein Multimerization; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Pyrimidines; Pyrroles; Sulfonamides; Thyroid Neoplasms; Treatment Outcome; Vemurafenib | 2017 |
RAGE-mediated extracellular matrix proteins accumulation exacerbates HySu-induced pulmonary hypertension.
Topics: Animals; Case-Control Studies; Cell Hypoxia; Cells, Cultured; Cytoskeletal Proteins; Disease Models, Animal; DNA-Binding Proteins; Extracellular Matrix Proteins; Extracellular Signal-Regulated MAP Kinases; Female; HMGB1 Protein; Humans; Hypertension, Pulmonary; Indoles; Intracellular Signaling Peptides and Proteins; Ligands; LIM Domain Proteins; Male; Middle Aged; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pulmonary Artery; Pyrroles; Receptor for Advanced Glycation End Products; RNA Interference; S100 Calcium Binding Protein beta Subunit; Transfection; Vascular Remodeling | 2017 |
Inhibition of the insulin-like growth factor-1 receptor potentiates acute effects of castration in a rat model for prostate cancer growth in bone.
Topics: Animals; Apoptosis; Bone Neoplasms; Cell Proliferation; Disease Models, Animal; Humans; Male; Neoplasm Staging; Phosphorylation; Prognosis; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Pyrimidines; Pyrroles; Rats; Receptor, IGF Type 1; Receptors, Somatomedin; Signal Transduction; Survival Rate; Tumor Cells, Cultured | 2017 |
Participation of Antidiuretic Hormone (ADH) in Asthma Exacerbations Induced by Psychological Stress via PKA/PKC Signal Pathway in Airway-Related Vagal Preganglionic Neurons (AVPNs).
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Asthma; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cytokines; Disease Models, Animal; Eosinophils; Female; Mice; Mice, Inbred BALB C; Morpholines; Neurons; Ovalbumin; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Receptors, Vasopressin; Signal Transduction; Spiro Compounds; Stress, Psychological; Vasopressins | 2017 |
Capillary Degeneration and Right Ventricular Remodeling Due to Hypoxic Stress with Sugen5416.
Topics: Animals; Blood Pressure; Capillaries; Disease Models, Animal; Endothelial Cells; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; In Situ Nick-End Labeling; Indoles; Male; MAP Kinase Signaling System; Myocardium; Myocytes, Cardiac; Oxidative Stress; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; RNA, Messenger; Ventricular Remodeling | 2017 |
Depletion of Tumor-Associated Macrophages with a CSF-1R Kinase Inhibitor Enhances Antitumor Immunity and Survival Induced by DC Immunotherapy.
Topics: Aminopyridines; Animals; Antigens, Neoplasm; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Dendritic Cells; Disease Models, Animal; Humans; Immunotherapy, Adoptive; Lung Neoplasms; Macrophages; Mesothelioma; Mesothelioma, Malignant; Neoplasm Invasiveness; Programmed Cell Death 1 Receptor; Protein Kinase Inhibitors; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor | 2017 |
Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors.
Topics: Animals; Binding Sites; Catalytic Domain; Cell Line; Crystallography, X-Ray; Disease Models, Animal; Drug Evaluation, Preclinical; Half-Life; Humans; Inflammation; Inhibitory Concentration 50; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Mice; Mice, Inbred BALB C; Molecular Conformation; Molecular Dynamics Simulation; Protein Kinase Inhibitors; Pyridazines; Pyrroles; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; TYK2 Kinase | 2017 |
GSK-3β as a target for protection against transient cerebral ischemia.
Topics: Animals; beta Catenin; Blood-Brain Barrier; Brain; Disease Models, Animal; Gene Expression Regulation; Glycogen Synthase Kinase 3 beta; Humans; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Pyrimidines; Pyrroles; Rats; Stroke; Wnt Signaling Pathway; Zonula Occludens-1 Protein | 2017 |
Improved efficacy of allergen-specific immunotherapy by JAK inhibition in a murine model of allergic asthma.
Topics: Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Differentiation; Cytokines; Desensitization, Immunologic; Disease Models, Animal; Humans; Janus Kinases; Mice; Mice, Inbred C57BL; Ovalbumin; Piperidines; Pyrimidines; Pyrroles | 2017 |
Depletion of p21-activated kinase 1 up-regulates the immune system of APC
Topics: Animals; Biomarkers; Cell Line, Tumor; Cell Transformation, Neoplastic; Colorectal Neoplasms; Disease Models, Animal; Genes, APC; Genotype; Immune System; Immunohistochemistry; Immunomodulation; Leukocyte Count; Lymphocytes; Mice; Mice, Knockout; Neutrophils; p21-Activated Kinases; Polycomb Repressive Complex 1; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pyrazoles; Pyrroles | 2017 |
Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates.
Topics: Animals; Antibodies, Monoclonal; Benzodiazepines; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Haplorhini; Humans; Immunoconjugates; Male; Mice; Prostatic Neoplasms; Pyrroles; Rats; Therapeutic Index; Trastuzumab; Xenograft Model Antitumor Assays | 2017 |
CRHR1 exacerbates the glial inflammatory response and alters BDNF/TrkB/pCREB signaling in a rat model of global cerebral ischemia: implications for neuroprotection and cognitive recovery.
Topics: Animals; Anxiety; Brain; Brain Ischemia; Brain-Derived Neurotrophic Factor; Central Nervous System Agents; Cognition; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Male; Neuroglia; Neuroimmunomodulation; Neuronal Plasticity; Neuroprotection; Pyrimidines; Pyrroles; Rats, Wistar; Receptor, trkB; Receptors, Corticotropin-Releasing Hormone; Recovery of Function; RNA, Messenger; Signal Transduction | 2017 |
The effects of enhancing endocannabinoid signaling and blocking corticotrophin releasing factor receptor in the amygdala and hippocampus on the consolidation of a stressful event.
Topics: Amidohydrolases; Animals; Anxiety; Basolateral Nuclear Complex; Benzamides; CA1 Region, Hippocampal; Carbamates; Disease Models, Animal; Endocannabinoids; Male; Memory Consolidation; Nootropic Agents; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Corticotropin-Releasing Hormone; Reflex, Startle; RNA, Messenger; Stress Disorders, Post-Traumatic; Stress, Psychological | 2017 |
Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas.
Topics: Aminopyridines; Animals; Becaplermin; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Glioma; Humans; Mice; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Tumor Microenvironment | 2017 |
Discovery of tricyclic dipyrrolopyridine derivatives as novel JAK inhibitors.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Biological Availability; Cell Membrane Permeability; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Female; Graft Survival; Heart Transplantation; Humans; Janus Kinases; Male; Molecular Structure; Protein Kinase Inhibitors; Pyridines; Pyrroles; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Rats, Sprague-Dawley; Structure-Activity Relationship | 2017 |
Combination therapy using molecular-targeted drugs modulates tumor microenvironment and impairs tumor growth in renal cell carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Therapy, Combination; Everolimus; Female; Humans; Immunohistochemistry; Indoles; Kidney Neoplasms; Luminescent Measurements; Mice; Molecular Imaging; Molecular Targeted Therapy; Neovascularization, Pathologic; Platelet-Derived Growth Factor; Pyrroles; Signal Transduction; Stromal Cells; Sunitinib; TOR Serine-Threonine Kinases; Tumor Burden; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2017 |
Selective glucocorticoid receptor modulation inhibits cytokine responses in a canine model of mild endotoxemia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Bone and Bones; C-Peptide; Cytokines; Disease Models, Animal; Dogs; Endotoxemia; Insulin; Male; Osteocalcin; Pyridines; Pyrimidines; Pyrroles; Receptors, Glucocorticoid | 2017 |
Early adolescent stress-induced changes in prefrontal cortex miRNA-135a and hippocampal miRNA-16 in male rats.
Topics: Age Factors; Animals; Anxiety; Disease Models, Animal; Hippocampus; Male; MicroRNAs; Paroxetine; Prefrontal Cortex; Pyrimidines; Pyrroles; Rats; Receptor, Serotonin, 5-HT1A; Receptors, Corticotropin-Releasing Hormone; Selective Serotonin Reuptake Inhibitors; Spatial Memory; Stress, Psychological | 2017 |
Effects of tofacitinib in early arthritis-induced bone loss in an adjuvant-induced arthritis rat model.
Topics: Adjuvants, Immunologic; Animals; Arthritis; Bone and Bones; Bone Remodeling; Bone Resorption; Disease Models, Animal; Female; Osteocalcin; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Treatment Outcome; X-Ray Microtomography | 2018 |
Prevention of chronic renal allograft rejection by AS2553627, a novel JAK inhibitor, in a rat transplantation model.
Topics: Allografts; Animals; Chronic Disease; Disease Models, Animal; Drug Therapy, Combination; Glomerulosclerosis, Focal Segmental; Graft Rejection; Humans; Interleukin-6; Janus Kinases; Kidney Transplantation; Piperidines; Pyrroles; Rats; Rats, Inbred Lew; Tacrolimus | 2018 |
A rat model of FOLFOX-induced neuropathy: effects of oral dimiracetam in comparison with duloxetine and pregabalin.
Topics: Administration, Oral; Animals; Disease Models, Animal; Duloxetine Hydrochloride; Fluorouracil; Humans; Imidazoles; Neuralgia; Pregabalin; Pyrroles; Rats; Rats, Sprague-Dawley | 2017 |
Reversal effects of low-dose imatinib compared with sunitinib on monocrotaline-induced pulmonary and right ventricular remodeling in rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Indoles; Male; Monocrotaline; Nestin; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-raf; Pulmonary Artery; Pyrroles; Rats, Wistar; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2018 |
Inhibition of JAK-STAT Signaling Suppresses Pathogenic Immune Responses in Medium and Large Vessel Vasculitis.
Topics: Adaptive Immunity; Adoptive Transfer; Aged; Animals; Cell Proliferation; Cytokines; Disease Models, Animal; Female; Gene Expression Regulation; Giant Cell Arteritis; Heterografts; Humans; Immunity, Innate; Immunologic Memory; Janus Kinase 1; Janus Kinase 3; Janus Kinase Inhibitors; Janus Kinases; Lymphocyte Activation; Male; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Middle Aged; Neointima; Neovascularization, Pathologic; Piperidines; Pyrimidines; Pyrroles; Signal Transduction; STAT Transcription Factors; T-Lymphocytes; Temporal Arteries; Vascular Remodeling | 2018 |
Loss of constitutive functional γ-aminobutyric acid type A-B receptor crosstalk in layer 5 pyramidal neurons of human epileptic temporal cortex.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adolescent; Adult; Animals; Baclofen; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Drug Resistant Epilepsy; Enzyme Inhibitors; Epilepsy; Epilepsy, Temporal Lobe; Female; GABA-B Receptor Agonists; Humans; Inhibitory Postsynaptic Potentials; Male; Middle Aged; Muscarinic Agonists; Neocortex; Patch-Clamp Techniques; Pertussis Toxin; Pilocarpine; Protein Kinase C; Pyramidal Cells; Pyrroles; Rats; Receptors, GABA-A; Receptors, GABA-B; Temporal Lobe | 2018 |
Inhibition of VEGF Signaling Reduces Diabetes-Exacerbated Brain Swelling, but Not Infarct Size, in Large Cerebral Infarction in Mice.
Topics: Animals; Blood Glucose; Brain Edema; Brain Ischemia; Cerebral Infarction; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucose Tolerance Test; Indoles; Insulin; Male; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; Proteoglycans; Pyrroles; RNA, Messenger; Signal Transduction; Stroke; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2018 |
In vivo potent BM635 analogue with improved drug-like properties.
Topics: Animals; Antitubercular Agents; Cell Proliferation; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Hep G2 Cells; Humans; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Pyrroles; Structure-Activity Relationship; Tuberculosis | 2018 |
Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Disease Models, Animal; Drug Discovery; HEK293 Cells; Humans; Mice; Mice, Nude; Myotonin-Protein Kinase; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Skin Neoplasms; Xenograft Model Antitumor Assays | 2018 |
Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis.
Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Ganglia, Spinal; Hand Strength; Iodoacetic Acid; Leucine; Male; Morpholines; Neurons; Osteoarthritis; Pain; Pain Measurement; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides; TRPV Cation Channels | 2018 |
Corticotrophin releasing factor receptor 1 antagonists prevent chronic stress-induced behavioral changes and synapse loss in aged rats.
Topics: Age Factors; Animals; Anxiety; Behavior; Behavior, Animal; Corticotropin-Releasing Hormone; Depression; Disease Models, Animal; Female; Hypothalamo-Hypophyseal System; Male; Pituitary-Adrenal System; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Stress, Psychological; Synapses | 2018 |
Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Aminopyridines; Amyloidogenic Proteins; Animals; Brain; Disease Models, Animal; Mice; Mice, Transgenic; Microglia; Neurons; Plaque, Amyloid; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor | 2018 |
Role of the Aryl Hydrocarbon Receptor in Su5416/Hypoxia-induced Pulmonary Hypertension: A New Mechanism for an "Old" Model.
Topics: Animals; Apoptosis; Azo Compounds; Cell Hypoxia; Disease Models, Animal; Emphysema; Endothelial Cells; Humans; Hypertension, Pulmonary; Indoles; Mice; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; Rats; Receptors, Aryl Hydrocarbon; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2018 |
Tofacitinib Halts Progression of Graft Dysfunction in a Rat Model of Mixed Cellular and Humoral Rejection.
Topics: Animals; Chronic Disease; Complement C4b; Disease Models, Animal; Disease Progression; Graft Rejection; Graft Survival; Humans; Immunity, Cellular; Immunity, Humoral; Immunosuppressive Agents; Janus Kinase 3; Kidney; Kidney Transplantation; Male; Peptide Fragments; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Signal Transduction; Treatment Outcome | 2018 |
Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment.
Topics: Animals; Bone Marrow; Cell Communication; Disease Models, Animal; Drug Repositioning; Humans; Janus Kinases; Mesenchymal Stem Cells; Mice; Multiple Myeloma; Phosphoproteins; Piperidines; Plasma Cells; Protein Kinase Inhibitors; Proteome; Proteomics; Pyrimidines; Pyrroles; Signal Transduction; STAT Transcription Factors; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2018 |
URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Disease Models, Animal; Hippocampus; Humans; Mice; Mice, Transgenic; Presenilin-1; Protein Kinase Inhibitors; Pyridines; Pyrroles | 2018 |
Licofelone Attenuates LPS-induced Depressive-like Behavior in Mice: A Possible Role for Nitric Oxide.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Injections, Intraperitoneal; Lipopolysaccharides; Male; Mice; Nitric Oxide; Pyrroles | 2018 |
A Gelatin Hydrogel-Containing Nano-Organic PEI⁻Ppy with a Photothermal Responsive Effect for Tissue Engineering Applications.
Topics: Animals; Disease Models, Animal; Gelatin; Hydrogels; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Molecular Structure; Nanoparticles; Polyethyleneimine; Porosity; Pyrroles; Rats; Rats, Wistar; Temperature; Tissue Engineering; Wound Healing | 2018 |
LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.
Topics: alpha-Synuclein; Animals; Animals, Newborn; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression Regulation; Hippocampus; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neurons; Organ Culture Techniques; Parkinson Disease; Pyrimidines; Pyrroles; Tyrosine 3-Monooxygenase | 2018 |
A non-retinoid antagonist of retinol-binding protein 4 rescues phenotype in a model of Stargardt disease without inhibiting the visual cycle.
Topics: Animals; Carboxylic Acids; Dark Adaptation; Disease Models, Animal; Lipofuscin; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrimidines; Pyrroles; Retina; Retinoids; Retinol-Binding Proteins, Plasma; Rhodopsin; Stargardt Disease | 2018 |
The preventive and therapeutic implication for renal fibrosis by targetting TGF-β/Smad3 signaling.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fibrosis; Isoquinolines; Kidney; Male; Mice, Inbred C57BL; Pyridines; Pyrroles; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta; Ureteral Obstruction | 2018 |
Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy.
Topics: Aminopyridines; Animals; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Diphtheria Toxin; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Forkhead Transcription Factors; Gene Knockout Techniques; Humans; Lymphocyte Depletion; Macrophages; Male; Mice; Mice, Transgenic; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Primary Cell Culture; Purines; Pyrroles; Quinazolinones; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; T-Lymphocytes, Regulatory; Tumor Microenvironment | 2018 |
DCE-MRI of Sunitinib-Induced Changes in Tumor Microvasculature and Hypoxia: A Study of Pancreatic Ductal Adenocarcinoma Xenografts.
Topics: Animals; Biomarkers; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Contrast Media; Disease Models, Animal; Female; Humans; Hypoxia; Image Enhancement; Immunohistochemistry; Indoles; Magnetic Resonance Imaging; Male; Mice; Neovascularization, Pathologic; Pancreatic Neoplasms; Pyrroles; Sunitinib; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2018 |
TRPV4 increases cardiomyocyte calcium cycling and contractility yet contributes to damage in the aged heart following hypoosmotic stress.
Topics: Age Factors; Animals; Calcium; Calcium Signaling; Disease Models, Animal; Humans; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Osmotic Pressure; Pyrroles; Sarcoplasmic Reticulum; TRPV Cation Channels | 2019 |
Comparison of topical tofacitinib and 0.1% hypochlorous acid in a murine atopic dermatitis model.
Topics: Administration, Topical; Animals; Cells, Cultured; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Female; Ganglia, Spinal; Hypochlorous Acid; Immunoglobulin E; Mice; Neurons; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Skin | 2018 |
Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice.
Topics: Adoptive Transfer; Adult; Animals; Antibodies; Blood Pressure; Bone Marrow; Cell Proliferation; Chimera; Chronic Disease; Disease Models, Animal; Female; Gene Deletion; Humans; Hypertension, Pulmonary; Hypoxia; Immunity; Indoles; Lung; Lymphocyte Activation; Male; Mice; Ovalbumin; Pulmonary Artery; Pyrroles; Receptors, Immunologic; Receptors, Prostaglandin; STAT6 Transcription Factor; Th2 Cells; Up-Regulation | 2018 |
Sustenance of endothelial cell stability in septic mice through appropriate activation of transient receptor potential vanilloid-4.
Topics: Animals; Apoptosis; Biomarkers; Blood Coagulation; Caspase 3; Cytoprotection; Disease Models, Animal; Endothelial Cells; Interleukin-6; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Morpholines; Pyrroles; Sepsis; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2018 |
The Sugen 5416/Hypoxia Mouse Model of Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Pulmonary Artery; Pyrroles; Vascular Remodeling | 2018 |
Pharmacological and toxicological activity of RSD921, a novel sodium channel blocker.
Topics: Action Potentials; Administration, Intravenous; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart Rate; Humans; Injections, Intradermal; Isolated Heart Preparation; Male; Mice; Myocytes, Cardiac; Neural Conduction; Pain Threshold; Papio; Pyrroles; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Thiophenes; Time Factors; Xenopus laevis | 2018 |
Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension.
Topics: Adult; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Extracellular Matrix; Female; Fibroblasts; Fibrosis; Humans; Indoles; Male; Myocardium; Protein Kinase Inhibitors; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling; Young Adult | 2019 |
Tamoxifen attenuates dialysate-induced peritoneal fibrosis by inhibiting GSK-3β/β-catenin axis activation.
Topics: Animals; beta Catenin; Disease Models, Animal; Epithelial-Mesenchymal Transition; Gene Expression Regulation; Glucose; Glycogen Synthase Kinase 3 beta; Humans; Matrix Metalloproteinase 9; Mice; Peritoneal Dialysis; Peritoneal Fibrosis; Peritoneum; Phosphorylation; Pyrimidines; Pyrroles; Snail Family Transcription Factors; Tamoxifen | 2018 |
Effects of toceranib compared with sorafenib on monocrotaline-induced pulmonary arterial hypertension and cardiopulmonary remodeling in rats.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Autophagy; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indoles; Male; Monocrotaline; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pulmonary Artery; Pyrroles; Rats, Wistar; Signal Transduction; Sorafenib; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2018 |
SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads.
Topics: Animals; Antineoplastic Agents, Immunological; Benzodiazepines; Biomarkers; Cell Line, Tumor; Disease Models, Animal; Gene Expression; Gene Silencing; Humans; Immunoconjugates; Maytansine; Melanoma, Experimental; Mice; Pyrroles; Xenograft Model Antitumor Assays | 2018 |
High-throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in alopecia areata.
Topics: Adolescent; Adult; Alopecia Areata; Animals; Autoimmune Diseases; CD8-Positive T-Lymphocytes; Disease Models, Animal; Female; Follow-Up Studies; Hair Follicle; High-Throughput Nucleotide Sequencing; Humans; Lymph Nodes; Male; Mice; Mice, Inbred C3H; Middle Aged; NK Cell Lectin-Like Receptor Subfamily K; Pilot Projects; Piperidines; Pyrimidines; Pyrroles; Receptors, Antigen, T-Cell; Scalp; Treatment Outcome; Young Adult | 2018 |
Dihydroorotate dehydrogenase inhibitor olorofim exhibits promising activity against all clinically relevant species within Aspergillus section Terrei.
Topics: Acetamides; Animals; Antifungal Agents; Aspergillosis; Aspergillus; Dihydroorotate Dehydrogenase; Disease Models, Animal; Immunocompromised Host; Invasive Fungal Infections; Male; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Oxidoreductases Acting on CH-CH Group Donors; Piperazines; Pyrimidines; Pyrroles | 2018 |
Small Molecule Derived From Carboxyethylpyrrole Protein Adducts Promotes Angiogenesis in a Mouse Model of Peripheral Arterial Disease.
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelium, Vascular; Female; Hindlimb; Humans; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Peripheral Arterial Disease; Pyrroles | 2018 |
Inhibition of protease-activated receptor 1 ameliorates behavioral deficits and restores hippocampal synaptic plasticity in a rat model of status epilepticus.
Topics: Animals; Behavior, Animal; CA1 Region, Hippocampal; Disease Models, Animal; Epilepsy, Temporal Lobe; Lithium; Long-Term Potentiation; Male; Pilocarpine; Pyrroles; Quinazolines; Rats, Wistar; Receptor, PAR-1; Status Epilepticus | 2019 |
Partial reduction of microglia does not affect tau pathology in aged mice.
Topics: Aging; Aminopyridines; Animals; Blood Vessels; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cytokines; Disease Models, Animal; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Mutation; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; RNA, Messenger; tau Proteins; Tauopathies | 2018 |
Antagonizing the corticotropin releasing hormone receptor 1 with antalarmin reduces the progression of endometriosis.
Topics: Animals; Disease Models, Animal; Disease Progression; Endometriosis; Female; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Treatment Outcome | 2018 |
Antipruritic Effects of Janus Kinase Inhibitor Tofacitinib in a Mouse Model of Psoriasis.
Topics: Animals; Antipruritics; Behavior, Animal; Disease Models, Animal; Imiquimod; Interleukin-22; Interleukin-23; Interleukins; Janus Kinase Inhibitors; Male; Mice, Inbred C57BL; Nerve Fibers; Piperidines; Pruritus; Psoriasis; Pyrimidines; Pyrroles; Skin | 2019 |
CrossTalk opposing view: The mouse SuHx model is not a good model of pulmonary arterial hypertension.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Mice; Pyrroles; Receptors, Vascular Endothelial Growth Factor | 2019 |
CrossTalk proposal: The mouse SuHx model is a good model of pulmonary arterial hypertension.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Mice; Pyrroles; Receptors, Vascular Endothelial Growth Factor | 2019 |
1-Pyrroline-5-carboxylate released by prostate Cancer cell inhibit T cell proliferation and function by targeting SHP1/cytochrome c oxidoreductase/ROS Axis.
Topics: Adenosine Triphosphate; Animals; Cell Line, Tumor; Cell Proliferation; Chromatography, Liquid; Cytochromes c; Cytokines; Disease Models, Animal; Electron Transport Chain Complex Proteins; Heterografts; Humans; Lymphocyte Activation; Male; Metabolome; Metabolomics; Mice; Mitochondria; Prostatic Neoplasms; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Pyrroles; Reactive Oxygen Species; T-Lymphocytes; Tandem Mass Spectrometry | 2018 |
Targeting microglia attenuates neuroinflammation-related neural damage in mice carrying human PLP1 mutations.
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Central Nervous System Diseases; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Microscopy, Electron, Transmission; Mutation; Myelin Proteolipid Protein; Neurons; Pyrroles; T-Lymphocytes; Tomography, Optical Coherence | 2019 |
Long-term characterization of activated microglia/macrophages facilitating the development of experimental brain metastasis through intravital microscopic imaging.
Topics: Aminopyridines; Animals; Brain; Brain Neoplasms; Cell Line, Tumor; CX3C Chemokine Receptor 1; Disease Models, Animal; Functional Laterality; Gene Expression Regulation, Neoplastic; Green Fluorescent Proteins; Intravital Microscopy; Macrophages; Matrix Metalloproteinase 3; Melanoma; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Pyrroles; Time Factors; Zonula Occludens-1 Protein | 2019 |
53BP1 Deficiency Promotes Pathological Neovascularization in Proliferative Retinopathy.
Topics: Animals; Apoptosis; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Genetic Predisposition to Disease; Homologous Recombination; Humans; Mice, Knockout; Morpholines; Phenotype; Pyrroles; Retinal Neovascularization; Retinal Vessels; Retinopathy of Prematurity; Signal Transduction; Tumor Suppressor p53-Binding Protein 1 | 2019 |
Effect of the CSF1R inhibitor PLX3397 on remyelination of corpus callosum in a cuprizone-induced demyelination mouse model.
Topics: Aminopyridines; Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Indoles; Macrophage Colony-Stimulating Factor; Male; Mice, Inbred C57BL; Microglia; Microscopy, Electron, Transmission; Multiple Sclerosis; Myelin Sheath; Pyrroles; Real-Time Polymerase Chain Reaction; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Rotarod Performance Test | 2019 |
Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea.
Topics: Acetamides; Afatinib; Animals; Cell Membrane Permeability; Clotrimazole; Colon; Cystic Fibrosis Transmembrane Conductance Regulator; Diarrhea; Disease Models, Animal; Epithelial Cells; ErbB Receptors; Female; Humans; Intestinal Mucosa; Neoplasms; Oxazines; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Pyrimidinones; Pyrroles; Rats; Trityl Compounds | 2019 |
BET Inhibition Modifies Melanoma Infiltrating T Cells and Enhances Response to PD-L1 Blockade.
Topics: Animals; Antineoplastic Agents, Immunological; CD8-Positive T-Lymphocytes; Cell Growth Processes; Cell Line, Tumor; Disease Models, Animal; Drug Synergism; Forkhead Transcription Factors; Humans; Immunotherapy; Lymphocytes, Tumor-Infiltrating; Melanoma; Mice; Nerve Tissue Proteins; Oxazoles; Programmed Cell Death 1 Receptor; Pyridines; Pyrroles; Receptors, Cell Surface; Skin Neoplasms; T-Lymphocytes, Regulatory; Tumor Burden | 2019 |
I
Topics: Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Diet, High-Fat; Disease Models, Animal; Heart Rate; Imidazoline Receptors; Lipids; Male; Metabolic Syndrome; Microcirculation; Pyrroles; Rats; Rats, Wistar; Sympathetic Nervous System | 2019 |
Tofacitinib enhances delivery of antibody-based therapeutics to tumor cells through modulation of inflammatory cells.
Topics: Animals; Antibodies; Arginase; Breast Neoplasms; Cell Line, Tumor; Cytokines; Disease Models, Animal; Female; Immunoconjugates; Immunotherapy; Immunotoxins; Macrophages; Mice; Mice, Nude; Monocytes; Neoplasms; Neutrophils; Piperidines; Pyrimidines; Pyrroles; RNA, Messenger; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2019 |
Beneficial effects of mesenchymal stem cell delivery via a novel cardiac bioscaffold on right ventricles of pulmonary arterial hypertensive rats.
Topics: Animals; Arterial Pressure; Cells, Cultured; Disease Models, Animal; Fibrosis; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Mesenchymal Stem Cell Transplantation; Myocardial Contraction; Myocardium; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Recovery of Function; Regeneration; Tissue Scaffolds; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling; von Willebrand Factor | 2019 |
A Macromolecular Janus Kinase (JAK) Inhibitor Prodrug Effectively Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice.
Topics: Animals; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Inflammation; Janus Kinases; Male; Methacrylates; Mice; Piperidines; Polymers; Prodrugs; Pyrimidines; Pyrroles | 2019 |
Renal expression of JAK2 is high in polycystic kidney disease and its inhibition reduces cystogenesis.
Topics: Animals; Cell Line; Cell Proliferation; Curcumin; Disease Models, Animal; Epithelial Cells; Humans; Janus Kinase 2; Kidney; Mice; Phosphorylation; Piperidines; Polycystic Kidney, Autosomal Dominant; Pyrimidines; Pyrroles; TRPP Cation Channels; Up-Regulation | 2019 |
The blockade of corticotropin-releasing factor 1 receptor attenuates anxiety-related symptoms and hypothalamus-pituitary-adrenal axis reactivity in mice with mild traumatic brain injury.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Anxiety Disorders; Brain Concussion; Corticosterone; Corticotropin-Releasing Hormone; Disease Models, Animal; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Inbred Strains; Pituitary-Adrenal System; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Stress, Physiological | 2019 |
The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Indoles; Lung; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley | 2019 |
Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice.
Topics: Animals; Antibodies; Azoxymethane; Benzamides; Carcinogens; Cell Line, Transformed; Cerebral Cortex; Disease Models, Animal; Hepatic Encephalopathy; Inflammation; Isoquinolines; Liver; Liver Failure, Acute; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neurons; Phagocytosis; Pyrazoles; Pyridines; Pyrroles; Receptor, Transforming Growth Factor-beta Type II; Signal Transduction; Transforming Growth Factor beta1; Up-Regulation | 2019 |
Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)-Dependent Pulmonary Arterial Hypertension.
Topics: Adolescent; Adult; Aged; Animals; Bone Morphogenetic Protein Receptors, Type II; Case-Control Studies; Caveolin 1; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Extracellular Vesicles; Female; Humans; Hypoxia; Indoles; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Nitric Oxide Synthase Type III; Pulmonary Arterial Hypertension; Pyrroles; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Vascular Remodeling; Young Adult | 2019 |
Janus kinase inhibitor tofacitinib does not facilitate the repigmentation in mouse model of rhododendrol-induced vitiligo.
Topics: Administration, Oral; Animals; Butanols; Disease Models, Animal; Humans; Janus Kinase Inhibitors; Mice; Mice, Hairless; Mice, Transgenic; Piperidines; Pyrimidines; Pyrroles; Skin Lightening Preparations; Skin Pigmentation; Treatment Failure; Vitiligo | 2019 |
Inhibition of miR-495 Improves Both Vascular Remodeling and Angiogenesis in Pulmonary Hypertension.
Topics: Angiogenic Proteins; Animals; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Cells, Cultured; Dependovirus; Disease Models, Animal; Genetic Therapy; Genetic Vectors; Hypertension, Pulmonary; Hypoxia; Indoles; Lung; Male; Mice, Inbred C57BL; MicroRNAs; Microvessels; Neovascularization, Physiologic; Pyrroles; Recovery of Function; Signal Transduction; Vascular Remodeling | 2019 |
Severe Emphysema in the SU5416/Hypoxia Rat Model of Pulmonary Hypertension.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Protein Kinase Inhibitors; Pulmonary Emphysema; Pyrroles; Rats; X-Ray Microtomography | 2019 |
Colony-stimulating factor 1 receptor inhibition prevents against lipopolysaccharide -induced osteoporosis by inhibiting osteoclast formation.
Topics: Aminopyridines; Animals; Biomechanical Phenomena; Bone Density; Bone Resorption; Cancellous Bone; Disease Models, Animal; Lipopolysaccharides; Male; Osteoclasts; Osteoporosis; Pyrroles; Rats, Sprague-Dawley; Receptor, Macrophage Colony-Stimulating Factor; Tibia | 2019 |
Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension.
Topics: Animals; Cell Line; Cyclin-Dependent Kinases; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Indoles; Lung; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Piperazines; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; Pyrroles; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Treatment Outcome | 2019 |
Vx-11e protects against titanium-particle-induced osteolysis and osteoclastogenesis by supressing ERK activity.
Topics: Animals; Cell Survival; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Male; Mice; Mice, Inbred C57BL; Osteoclasts; Osteogenesis; Particle Size; Protective Agents; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Titanium | 2019 |
Effect of a Vasopressin V2 Receptor Antagonist on Polycystic Kidney Disease Development in a Rat Model.
Topics: Administration, Oral; Animals; Antidiuretic Hormone Receptor Antagonists; Benzamides; Creatinine; Cysts; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Kidney; Liver; Liver Diseases; Mutation; Organ Size; Polycystic Kidney, Autosomal Dominant; Pyrroles; Rats; Receptors, Cell Surface; Receptors, Vasopressin | 2019 |
Target identification, screening and in vivo evaluation of pyrrolone-fused benzosuberene compounds against human epilepsy using Zebrafish model of pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Class I Phosphatidylinositol 3-Kinases; Coumarins; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Gene Expression Profiling; Gene Expression Regulation; Humans; Molecular Docking Simulation; Pentylenetetrazole; Proto-Oncogene Proteins c-akt; Pyrroles; Signal Transduction; TOR Serine-Threonine Kinases; Zebrafish; Zebrafish Proteins | 2019 |
Chronic inflammation, cognitive impairment, and distal brain region alteration following intracerebral hemorrhage.
Topics: Aminopyridines; Animals; Brain; Cerebral Hemorrhage; Cognition; Cognitive Dysfunction; Disease Models, Animal; Fingolimod Hydrochloride; Flow Cytometry; Hippocampus; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroimaging; Neuronal Plasticity; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor | 2019 |
Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension.
Topics: Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Energy Metabolism; High-Throughput Screening Assays; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Male; Metabolome; Mice; Mitochondria; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthoquinones; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats; Reactive Oxygen Species; Resorcinols; Transcription Factors | 2019 |
IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization.
Topics: Aminopyridines; Animals; Cell Degranulation; Cromolyn Sodium; Disease Models, Animal; Epithelium; Female; Gastric Mucosa; Humans; Interleukin-1 Receptor-Like 1 Protein; Interleukin-33; Macrophages; Male; Mast Cells; Mice; Mice, Transgenic; Pyrroles; Signal Transduction; Stomach Neoplasms; Tissue Array Analysis; Tumor Microenvironment | 2019 |
FGF-2 signaling activation in the hippocampus contributes to the behavioral and cellular responses to puerarin.
Topics: Anhedonia; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Fibroblast Growth Factor 2; Food Preferences; Hippocampus; Isoflavones; Male; Mice; Mice, Inbred C57BL; Neurogenesis; Pyrroles; Receptor, Fibroblast Growth Factor, Type 1; Stress, Psychological | 2019 |
Antiretroviral drug-induced endothelial dysfunction is improved by dual PPARα/γ stimulation in obesity.
Topics: Animals; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Aorta, Thoracic; Disease Models, Animal; Endothelium, Vascular; Male; NADPH Oxidases; Nitric Oxide Synthase Type III; Obesity; Phenylpropionates; PPAR alpha; PPAR gamma; Proto-Oncogene Proteins c-akt; Pyrroles; Rats, Wistar; Signal Transduction; Vasodilation | 2019 |
Role of corticotropin-releasing factor on bladder function in rats with psychological stress.
Topics: Animals; Case-Control Studies; Corticotropin-Releasing Hormone; Disease Models, Animal; Injections, Intraperitoneal; Male; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Corticotropin-Releasing Hormone; Stress, Psychological; Urinary Bladder; Urination | 2019 |
Inhibition of PDE5 attenuates streptozotocin-induced neuroinflammation and tau hyperphosphorylation in a streptozotocin-treated rat model.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Encephalitis; Insulin; Male; Phosphodiesterase 5 Inhibitors; Phosphorylation; Pyrimidinones; Pyrroles; Rats, Wistar; Streptozocin; tau Proteins | 2019 |
A novel fluorescent probe for the early detection of prostate cancer based on endogenous zinc sensing.
Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Disease Models, Animal; Early Detection of Cancer; Fluorescent Dyes; Humans; Ions; Ketones; Male; Mice; Mice, Inbred BALB C; Prostatic Neoplasms; Pyrroles; Zinc | 2019 |
TGF-β signaling promotes tube-structure-forming growth in pancreatic duct adenocarcinoma.
Topics: Animals; Benzamides; Carcinogenesis; Carcinoma, Pancreatic Ductal; Cell Culture Techniques; Cell Line, Tumor; Dioxoles; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Pancreatic Neoplasms; Pyrazoles; Pyrroles; Recombinant Proteins; RNA-Seq; Signal Transduction; Spheroids, Cellular; Transforming Growth Factor beta1 | 2019 |
Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates interstitial lung disease in SKG mice.
Topics: Animals; Cell Differentiation; Cell Proliferation; Dendritic Cells; Disease Models, Animal; Immunity, Innate; Lung Diseases, Interstitial; Male; Mice; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Th17 Cells | 2019 |
Atorvastatin protects against deleterious cardiovascular consequences induced by chronic intermittent hypoxia.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Blood Pressure; Cardiovascular Diseases; Disease Models, Animal; Heptanoic Acids; Hypoxia; Oxidative Stress; Pyrroles; Rats; Treatment Outcome | 2013 |
CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.
Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Cycle Proteins; Cell Line, Transformed; Disease Models, Animal; DNA-Binding Proteins; Enzyme Inhibitors; Frontal Lobe; Gene Expression Regulation; Humans; Movement; Mutation; Neurodegenerative Diseases; Phosphorylation; Piperidones; Protein Serine-Threonine Kinases; Pyrroles; RNA, Small Interfering; Serine; TDP-43 Proteinopathies; Transfection | 2013 |
Enhanced effectivity of an ALK5-inhibitor after cell-specific delivery to hepatic stellate cells in mice with liver injury.
Topics: Animals; Collagen; Disease Models, Animal; Hepatic Stellate Cells; Hepatocytes; Humans; Liver Cirrhosis; Male; Mice; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Rats; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta | 2013 |
Altered microRNA expression in the ischemic-reperfusion spinal cord with atorvastatin therapy.
Topics: Animals; Atorvastatin; Disease Models, Animal; Gene Expression; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; MicroRNAs; Neuroprotective Agents; Pyrroles; Rats; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Spinal Cord; Spinal Cord Ischemia | 2013 |
Establishment of a novel experimental model of human angiosarcoma and a VEGF-targeting therapeutic experiment.
Topics: Aged, 80 and over; Angiogenesis Inhibitors; Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal, Humanized; Bevacizumab; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Hemangiosarcoma; Heterografts; Humans; In Vitro Techniques; Indoles; Male; Mice; Mice, Inbred NOD; Mice, SCID; Pyrroles; Receptor Protein-Tyrosine Kinases; Signal Transduction; Skin Neoplasms; Sunitinib; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2013 |
Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology.
Topics: Adult; Aged; Animals; Apoptosis; Arterial Pressure; Bone Morphogenetic Protein Receptors, Type II; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Glycation End Products, Advanced; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR gamma; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA Interference; S100 Proteins; Signal Transduction; STAT3 Transcription Factor; Transfection; Up-Regulation | 2013 |
Atorvastatin improves cognitive, emotional and motor impairments induced by intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in rats, an experimental model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Administration, Intranasal; Analysis of Variance; Animals; Antiparkinson Agents; Atorvastatin; Brain; Cognition Disorders; Cytokines; Disease Models, Animal; Food Preferences; Heptanoic Acids; Male; Maze Learning; Mood Disorders; Motor Activity; Parkinsonian Disorders; Pyrroles; Rats; Rats, Wistar; Social Behavior; Sucrose; Sweetening Agents; Swimming; Tyrosine 3-Monooxygenase | 2013 |
Synergistical neuroprotection of rofecoxib and statins against malonic acid induced Huntington's disease like symptoms and related cognitive dysfunction in rats.
Topics: Animals; Atorvastatin; Behavior, Animal; Brain; Cognition Disorders; Cyclooxygenase 2 Inhibitors; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Heptanoic Acids; Huntington Disease; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactones; Male; Malonates; Neurons; Neuroprotective Agents; Nootropic Agents; Oxidative Stress; Pyrroles; Rats; Rats, Wistar; Simvastatin; Sulfones | 2013 |
Sunitinib inhibits inflammatory corneal lymphangiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Cell Proliferation; Corneal Neovascularization; Disease Models, Animal; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Glycoproteins; Indoles; Lymphangiogenesis; Lymphatic Vessels; Macrophages, Peritoneal; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Placenta Growth Factor; Platelet Endothelial Cell Adhesion Molecule-1; Pregnancy Proteins; Protein-Tyrosine Kinases; Pyrroles; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sunitinib; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2013 |
Monitoring plaque inflammation in atherosclerotic rabbits with an iron oxide (P904) and (18)F-FDG using a combined PET/MR scanner.
Topics: Animals; Aorta, Abdominal; Aortic Diseases; Atherosclerosis; Atorvastatin; Contrast Media; Dextrans; Disease Models, Animal; Disease Progression; Fluorodeoxyglucose F18; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Magnetic Resonance Imaging; Magnetite Nanoparticles; Plaque, Atherosclerotic; Positron-Emission Tomography; Predictive Value of Tests; Pyrroles; Rabbits; Radiography; Radiopharmaceuticals; Time Factors | 2013 |
Impact of methylene blue and atorvastatin combination therapy on the apparition of cerebral malaria in a murine model.
Topics: Animals; Antimalarials; Atorvastatin; Disease Models, Animal; Drug Synergism; Female; Heptanoic Acids; Kaplan-Meier Estimate; Malaria, Cerebral; Methylene Blue; Mice; Mice, Inbred C57BL; Parasitemia; Pyrroles | 2013 |
Protease-activated receptor 1 inhibition by SCH79797 attenuates left ventricular remodeling and profibrotic activities of cardiac fibroblasts.
Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Imaging, Three-Dimensional; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Infarction; Myocardial Reperfusion Injury; Phosphorylation; Pyrroles; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, PAR-1; Transforming Growth Factor beta; Ventricular Remodeling | 2013 |
A model of postsurgical advanced metastatic breast cancer more accurately replicates the clinical efficacy of antiangiogenic drugs.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Indoles; Mice; Mice, SCID; Neoplasm Metastasis; Neoplasm Transplantation; Pyrroles; Randomized Controlled Trials as Topic; Research Design; Sunitinib; Time Factors; Treatment Outcome | 2013 |
Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice--a translational model for atherosclerosis.
Topics: Animals; Anticholesteremic Agents; Apolipoprotein E3; Atherosclerosis; Atorvastatin; Cholesterol Ester Transfer Proteins; Cholesterol, Dietary; Disease Models, Animal; Heptanoic Acids; Humans; Hypercholesterolemia; Mice; Mice, Transgenic; Osteoarthritis; Pyrroles | 2014 |
Pharmacologic inhibition of CXCL10 in combination with anti-malarial therapy eliminates mortality associated with murine model of cerebral malaria.
Topics: Animals; Antimalarials; Apoptosis; Artemether; Artemisinins; Atorvastatin; Blood-Brain Barrier; Caspases; Cell Count; Chemokine CXCL10; Disease Models, Animal; Drug Interactions; Endothelial Cells; Gene Expression Regulation; Heme Oxygenase-1; Heptanoic Acids; Humans; Leukocytes; Malaria, Cerebral; Membrane Proteins; Mice; Mice, Inbred C57BL; Models, Molecular; Neuroglia; Nucleic Acid Conformation; Pyrroles; Survival Analysis | 2013 |
JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Animals; Case-Control Studies; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Humans; Janus Kinase 3; Lymphoma, Extranodal NK-T-Cell; Male; Mice; Middle Aged; Mutation; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
PPARα is involved in the multitargeted effects of a pretreatment with atorvastatin in experimental stroke.
Topics: Animals; Atorvastatin; Cerebral Cortex; Disease Models, Animal; Gene Expression; Heptanoic Acids; Intercellular Adhesion Molecule-1; Interleukin-6; Lipids; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; Nitric Oxide Synthase Type II; PPAR alpha; Pyrroles; Stroke; Vascular Cell Adhesion Molecule-1 | 2014 |
Focal histopathological progression of porcine experimental abdominal aortic aneurysm is mitigated by atorvastatin.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Atorvastatin; Disease Models, Animal; Disease Progression; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pancreatic Elastase; Pyrroles; Sus scrofa; Time Factors; Ultrasonography | 2013 |
Effect of atorvastatin on expression of TLR4 and NF-κB p65 in atherosclerotic rabbits.
Topics: Animals; Anticholesteremic Agents; Aorta; Atherosclerosis; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Disease Models, Animal; Gene Expression; Heptanoic Acids; Histocytochemistry; Male; Pyrroles; Rabbits; Random Allocation; Toll-Like Receptor 4; Transcription Factor RelA | 2013 |
TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension.
Topics: Animals; Calcium Signaling; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypoxia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Pulmonary Artery; Pyrroles; Serotonin; Sulfonamides; Time Factors; TRPV Cation Channels; Vasoconstriction; Vasoconstrictor Agents | 2013 |
Atorvastatin enhance efficacy of mesenchymal stem cells treatment for swine myocardial infarction via activation of nitric oxide synthase.
Topics: Animals; Apoptosis; Atorvastatin; C-Reactive Protein; Disease Models, Animal; Enzyme Activation; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Mesenchymal Stem Cell Transplantation; Myocardial Infarction; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pyrroles; Swine; Tomography, Emission-Computed, Single-Photon; Ventricular Function, Left | 2013 |
The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders.
Topics: Animals; Bone Marrow Transplantation; Cell Line, Transformed; Cells, Cultured; CX3C Chemokine Receptor 1; Cytokines; Disease Models, Animal; Embryo, Mammalian; Gene Products, tat; Green Fluorescent Proteins; Hippocampus; HIV Infections; HIV-1; Humans; Inflammation; MAP Kinase Kinase Kinases; Mice; Mice, Transgenic; Microscopy, Immunoelectron; Mitogen-Activated Protein Kinase Kinase Kinase 11; Neuroprotective Agents; Phagocytosis; Phosphorylation; Pyridines; Pyrroles; Rats; Receptors, Chemokine; Signal Transduction; Statistics, Nonparametric; tat Gene Products, Human Immunodeficiency Virus; Time Factors; Transfection | 2013 |
Atorvastatin reduces myocardial fibrosis in a rat model with post-myocardial infarction heart failure by increasing the matrix metalloproteinase-2/tissue matrix metalloproteinase inhibitor-2 ratio.
Topics: Animals; Atorvastatin; Collagen; Disease Models, Animal; Female; Fibrosis; Heart Failure; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Matrix Metalloproteinase 2; Myocardial Infarction; Myocardium; Pyrroles; Rats; Rats, Wistar; Tissue Inhibitor of Metalloproteinase-2; Ventricular Remodeling | 2013 |
Atorvastatin counteracts aberrant soft tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6⁻/⁻).
Topics: Animals; Atorvastatin; ATP-Binding Cassette Transporters; Calcinosis; Calcium; Connective Tissue; Dermis; Disease Models, Animal; Genotype; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Mice; Mice, Knockout; Pseudoxanthoma Elasticum; Pyrroles | 2013 |
Neuropilin-1 modulates vascular endothelial growth factor-induced poly(ADP-ribose)-polymerase leading to reduced cerebrovascular apoptosis.
Topics: Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Gene Expression Regulation; Humans; Indoles; Infarction, Middle Cerebral Artery; Male; Neurons; Neuropilin-1; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Time Factors; Umbilical Veins; Vascular Endothelial Growth Factor A | 2013 |
Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Endothelium, Vascular; Familial Primary Pulmonary Hypertension; Female; Hypertension, Pulmonary; Hypoxia; Indoles; Lac Operon; Male; Mice; Mice, Transgenic; Phenotype; Protein Serine-Threonine Kinases; Pulmonary Circulation; Pyrroles; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Receptors, Vascular Endothelial Growth Factor; Scleroderma, Systemic; Signal Transduction; Transforming Growth Factor beta | 2013 |
Autocrine IGF-I/insulin receptor axis compensates for inhibition of AKT in ER-positive breast cancer cells with resistance to estrogen deprivation.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Estrogen Receptor Modulators; Female; Humans; Insulin-Like Growth Factor I; Ligands; MCF-7 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptor, IGF Type 1; Receptor, Insulin; Receptors, Estrogen; Tumor Burden; Up-Regulation; Xenograft Model Antitumor Assays | 2013 |
MicroRNA-22 downregulation by atorvastatin in a mouse model of cardiac hypertrophy: a new mechanism for antihypertrophic intervention.
Topics: Angiotensin II; Animals; Anticholesteremic Agents; Atorvastatin; Atrial Natriuretic Factor; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Down-Regulation; Heptanoic Acids; Male; Mice; MicroRNAs; Myocardium; Myocytes, Cardiac; Myosin Heavy Chains; Natriuretic Peptide, Brain; Oligonucleotides, Antisense; Phosphoric Monoester Hydrolases; PTEN Phosphohydrolase; Pyrroles; Rats | 2013 |
Antihyperalgesic and anti-inflammatory effects of atorvastatin in chronic constriction injury-induced neuropathic pain in rats.
Topics: Analgesia; Animals; Anti-Inflammatory Agents; Atorvastatin; Constriction; Dinoprostone; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1beta; Male; Matrix Metalloproteinase 2; Nerve Growth Factor; Neuralgia; Pain Measurement; Pyrroles; Rats; Rats, Wistar; Sciatic Nerve; Spinal Cord; Tumor Necrosis Factor-alpha | 2013 |
Insulin-dependent diabetes induced by pancreatic beta cell expression of IL-15 and IL-15Rα.
Topics: Animals; Diabetes Mellitus, Type 1; Disease Models, Animal; Humans; Insulin-Secreting Cells; Interleukin-15; Interleukin-15 Receptor alpha Subunit; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Transgenic; Piperidines; Pyrimidines; Pyrroles; Signal Transduction | 2013 |
Combination therapy with atorvastatin and amlodipine suppresses angiotensin II-induced aortic aneurysm formation.
Topics: Amlodipine; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apoptosis; Atorvastatin; Blood Pressure; Calcium Channel Blockers; Disease Models, Animal; Drug Therapy, Combination; Enzyme Activation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lipids; Male; Matrix Metalloproteinases; Mice; Mice, Knockout; Pyrroles; rho-Associated Kinases | 2013 |
Aurora and IKK kinases cooperatively interact to protect multiple myeloma cells from Apo2L/TRAIL.
Topics: Aged; Aged, 80 and over; Animals; Apoptosis; Aurora Kinase A; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Humans; I-kappa B Kinase; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Multiple Myeloma; Piperazines; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Xenograft Model Antitumor Assays | 2013 |
Effect of atorvastatin on atherosclerotic plaque formation and platelet activation in hypercholesterolemic rats.
Topics: Animals; Aorta; Aortic Diseases; Atherosclerosis; Atorvastatin; Biomarkers; CD40 Antigens; CD40 Ligand; Cholesterol, Dietary; Disease Models, Animal; Disease Progression; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Interleukin-6; Lipids; Male; P-Selectin; Plaque, Atherosclerotic; Platelet Activation; Platelet Factor 4; Pyrroles; Rats; Rats, Wistar | 2013 |
Improvement of the efficacy of dihydroartemisinin with atorvastatin in an experimental cerebral malaria murine model.
Topics: Animals; Anti-Inflammatory Agents; Antimalarials; Artemisinins; Atorvastatin; Biomarkers; Disease Models, Animal; Drug Therapy, Combination; Female; Heptanoic Acids; Inflammation; Malaria, Cerebral; Mice; Mice, Inbred C57BL; Pyrroles; Survival Analysis; Treatment Outcome | 2013 |
Atorvastatin improves microenvironment to enhance the beneficial effects of BMSCs therapy in a rabbit model of acute myocardial infarction.
Topics: Animals; Atorvastatin; Cells, Cultured; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Mesenchymal Stem Cell Transplantation; Myocardial Infarction; Myocytes, Cardiac; Pyrroles; Rabbits | 2013 |
Sulphiredoxin plays peroxiredoxin-dependent and -independent roles via the HOG signalling pathway in Cryptococcus neoformans and contributes to fungal virulence.
Topics: Animals; Anti-Infective Agents, Local; Cryptococcosis; Cryptococcus neoformans; Dioxoles; Disease Models, Animal; Ergosterol; Female; Fungal Proteins; Gene Deletion; Gene Expression Regulation, Fungal; Genes, Fungal; Humans; Hydrogen Peroxide; Mice; Mice, Inbred CBA; Peroxiredoxins; Pyrroles; Signal Transduction | 2013 |
Synergistic effects of atorvastatin and all-trans retinoic acid in ameliorating animal model of multiple sclerosis.
Topics: Animals; Atorvastatin; Brain; Cytokines; Disease Models, Animal; Drug Synergism; Encephalomyelitis, Autoimmune, Experimental; Female; Forkhead Transcription Factors; Heptanoic Acids; Mice; Multiple Sclerosis; Pyrroles; T-Lymphocytes, Regulatory; Tretinoin; Weight Loss | 2014 |
The AKT inhibitor AZD5363 is selectively active in PI3KCA mutant gastric cancer, and sensitizes a patient-derived gastric cancer xenograft model with PTEN loss to Taxotere.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asian People; Cell Line, Tumor; Cell Proliferation; China; Disease Models, Animal; Docetaxel; Female; Humans; Immunohistochemistry; Mice; Mice, Nude; Mutation; Nuclear Proteins; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyrimidines; Pyrroles; Stomach Neoplasms; Taxoids; Transcription Factors; Treatment Outcome; Xenograft Model Antitumor Assays | 2013 |
CEP biomarkers as potential tools for monitoring therapeutics.
Topics: Animals; Autoantibodies; Biomarkers; Disease Models, Animal; Docosahexaenoic Acids; Light; Macular Degeneration; Male; Oxidation-Reduction; Pyrroles; Rats; Retina | 2013 |
TRPC4 inactivation confers a survival benefit in severe pulmonary arterial hypertension.
Topics: Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Cardiac Output; Disease Models, Animal; Hypertension, Pulmonary; Indoles; Male; Pulmonary Artery; Pyrroles; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Time Factors; TRPC Cation Channels | 2013 |
A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation.
Topics: Allografts; Animals; Atorvastatin; Biopsy; Cohort Studies; Dasatinib; Databases as Topic; Disease Models, Animal; Drug Approval; Electronic Health Records; Gene Expression Regulation; Gene Regulatory Networks; Graft Rejection; Graft Survival; Heart Transplantation; Heptanoic Acids; Humans; Kidney; Kidney Transplantation; Meta-Analysis as Topic; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Organ Specificity; Pyrimidines; Pyrroles; Reproducibility of Results; Retrospective Studies; Thiazoles; Transplantation; United States; United States Food and Drug Administration | 2013 |
Dual HER/VEGF receptor targeting inhibits in vivo ovarian cancer tumor growth.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cluster Analysis; Disease Models, Animal; Disease Progression; Female; Humans; Mice; Neoplasm Grading; Ovarian Neoplasms; Piperidines; Protein Kinase Inhibitors; Proteomics; Pyrroles; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Triazines; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
Inhibition of corneal neovascularization by subconjunctival and topical bevacizumab and sunitinib in a rabbit model.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Corneal Neovascularization; Disease Models, Animal; Female; Indoles; Pyrroles | 2013 |
Reply: To PMID 23377751.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Corneal Neovascularization; Disease Models, Animal; Female; Indoles; Pyrroles | 2013 |
Inhibitory effect of co-administration of atorvastatin and endothelin-1 receptor antagonist on the progression of atherosclerosis in rabbit.
Topics: Animals; Aorta, Abdominal; Atherosclerosis; Atorvastatin; Diet, High-Fat; Disease Models, Animal; Disease Progression; Down-Regulation; Drug Synergism; Drug Therapy, Combination; Endothelin A Receptor Antagonists; Endothelin-1; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Iliac Artery; Inflammation Mediators; Lipids; Male; Matrix Metalloproteinase 9; NF-kappa B; Phenylpropionates; Plaque, Atherosclerotic; Pyrimidines; Pyrroles; Rabbits; RNA, Messenger | 2014 |
Near-infrared fluorescence imaging of murine atherosclerosis using an oxidized low density lipoprotein-targeted fluorochrome.
Topics: Animals; Antibodies; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Atorvastatin; Cell Line; Cholesterol, Dietary; Disease Models, Animal; Disease Progression; Feasibility Studies; Fluorescent Dyes; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isothiocyanates; Lipoproteins, LDL; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Optical Imaging; Plaque, Atherosclerotic; Pyrroles; Time Factors | 2014 |
Evaluation of anastomotic strength and drug safety after short-term sunitinib administration in rabbits.
Topics: Administration, Oral; Anastomosis, Surgical; Angiogenesis Inhibitors; Animals; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Heart; Indoles; Liver; Placebos; Postoperative Complications; Pyrroles; Rabbits; Random Allocation; Stress, Mechanical; Sunitinib; Wound Healing | 2014 |
Inflammatory stress induces statin resistance by disrupting 3-hydroxy-3-methylglutaryl-CoA reductase feedback regulation.
Topics: Animals; Apolipoproteins E; Atorvastatin; CD36 Antigens; Cholesterol; Cholesterol, Dietary; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Feedback, Physiological; Hep G2 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Inflammation; Inflammation Mediators; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pyrroles; RNA Interference; Scavenger Receptors, Class A; Stress, Physiological; Time Factors; Transfection | 2014 |
[Vascular morphological and microdensity changes of corneal neovascularization induced by topical bevacizumab and sunitinib in an animal model].
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Arteries; Bevacizumab; Cornea; Corneal Neovascularization; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Synergism; Indoles; Male; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pyrroles; Rabbits; Sunitinib; Sutures; Vascular Endothelial Growth Factor A; Veins | 2013 |
The therapeutic potential of atorvastatin in a mouse model of postoperative cognitive decline.
Topics: Administration, Oral; Animals; Atorvastatin; Cognition; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Memory; Mice; Mice, Inbred C57BL; Nephrectomy; Postoperative Complications; Pyrroles; Recovery of Function; Treatment Outcome | 2014 |
10-Dehydrogingerdione raises HDL-cholesterol through a CETP inhibition and wards off oxidation and inflammation in dyslipidemic rabbits.
Topics: Animals; Atorvastatin; C-Reactive Protein; Cell Proliferation; Cholesterol Ester Transfer Proteins; Cholesterol, HDL; Diet, Atherogenic; Disease Models, Animal; Dyslipidemias; Guaiacol; Heptanoic Acids; Inflammation; Male; Mass Spectrometry; Oxygen; Pyrroles; Rabbits; Risk Factors | 2013 |
The thyroid receptor modulator KB3495 reduces atherosclerosis independently of total cholesterol in the circulation in ApoE deficient mice.
Topics: Animals; Anticholesteremic Agents; Apolipoproteins B; Apolipoproteins E; Atherosclerosis; Atorvastatin; Bile Acids and Salts; Biological Transport; Cytokines; Disease Models, Animal; Drug Synergism; Feces; Heptanoic Acids; Male; Mice; Mice, Knockout; Molecular Mimicry; Plaque, Atherosclerotic; Pyrroles; Thyroid Hormones | 2013 |
Effects of topical Janus kinase inhibition on ocular surface inflammation and immunity.
Topics: Adaptive Immunity; Administration, Topical; Animals; CD11b Antigen; Cell Movement; Cytokines; Disease Models, Animal; Dry Eye Syndromes; Female; Flow Cytometry; Gene Expression Regulation; Janus Kinase 3; Keratitis; Leukocyte Common Antigens; Leukocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ophthalmic Solutions; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Real-Time Polymerase Chain Reaction; Receptors, Chemokine | 2014 |
BH3-mimetic drugs prevent tumour onset in an orthotopic mouse model of hepatoblastoma.
Topics: Animals; Biomimetic Materials; Biphenyl Compounds; Cell Transformation, Neoplastic; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Hepatoblastoma; Humans; Indoles; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Nude; Mice, Transgenic; Nitrophenols; Peptide Fragments; Piperazines; Proto-Oncogene Proteins; Pyrroles; Sulfonamides | 2014 |
Atorvastatin and sildenafil lower blood pressure and improve endothelial dysfunction, but only atorvastatin increases vascular stores of nitric oxide in hypertension.
Topics: Animals; Aorta; Atorvastatin; Blood Pressure; Body Weight; Disease Models, Animal; Drug Therapy, Combination; Heptanoic Acids; Hypertension, Renovascular; Male; Nitric Oxide; Piperazines; Purines; Pyrroles; Rats; Rats, Wistar; Sildenafil Citrate; Sulfonamides | 2013 |
APOE*3Leiden.CETP transgenic mice as model for pharmaceutical treatment of the metabolic syndrome.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Apolipoprotein E3; Atorvastatin; Cholesterol Ester Transfer Proteins; Disease Models, Animal; Fenofibrate; Glucagon-Like Peptide 1; Heptanoic Acids; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Liraglutide; Male; Metabolic Syndrome; Mice, Transgenic; Niacin; Non-alcoholic Fatty Liver Disease; Obesity; Pyrroles; Rosiglitazone; Thiazolidinediones | 2014 |
Effects of atorvastatin, amlodipine, and their combination on vascular dysfunction in insulin-resistant rats.
Topics: Amlodipine; Animals; Atorvastatin; Biopterins; Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Fructose; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin Resistance; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrroles; Rats; Rats, Sprague-Dawley; Superoxides; Vasoconstriction; Vasodilation | 2014 |
Inhibition of vascular endothelial growth factor receptor under hypoxia causes severe, human-like pulmonary arterial hypertension in mice: potential roles of interleukin-6 and endothelin.
Topics: Animals; Biomarkers; Body Weight; Cell Hypoxia; Cell Line; Disease Models, Animal; Endothelial Cells; Endothelin-1; Heart Rate; Humans; Hypertension, Pulmonary; Indoles; Inflammation; Interleukin-6; Lung; Male; Mice; Pulmonary Artery; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Up-Regulation | 2014 |
Combination therapy of amlodipine and atorvastatin has more beneficial vascular effects than monotherapy in salt-sensitive hypertension.
Topics: Amlodipine; Animals; Antihypertensive Agents; Aorta; Atorvastatin; Blood Pressure; C-Reactive Protein; Calcium Channel Blockers; Chemokine CCL2; Disease Models, Animal; Drug Therapy, Combination; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Hypertrophy; Male; Nitric Oxide Synthase Type III; Pyrroles; Rats, Inbred Dahl; Scavenger Receptors, Class E; Sodium Chloride, Dietary; Superoxides; Time Factors; Vasodilation | 2014 |
Atorvastatin treatment attenuates renal injury in an experimental model of ischemia-reperfusion in rats.
Topics: Acute Kidney Injury; Animals; Anticholesteremic Agents; Atorvastatin; Disease Models, Animal; Glomerular Filtration Rate; Heptanoic Acids; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Treatment Outcome | 2014 |
Broad spectrum and prolonged efficacy of dimiracetam in models of neuropathic pain.
Topics: Analysis of Variance; Animals; Anti-Retroviral Agents; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Hyperalgesia; Imidazoles; Male; Neuralgia; Osteoarthritis, Knee; Paclitaxel; Pain Measurement; Pain Threshold; Physical Stimulation; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Vincristine; Weight-Bearing | 2014 |
Neither T-helper type 2 nor Foxp3+ regulatory T cells are necessary for therapeutic benefit of atorvastatin in treatment of central nervous system autoimmunity.
Topics: Adenylyl Cyclases; Animals; Atorvastatin; Cell Differentiation; Cell Proliferation; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Forkhead Transcription Factors; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-4; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pyrroles; Rats; STAT6 Transcription Factor; T-Lymphocytes, Regulatory; Th2 Cells | 2014 |
Pyrrolo[1,2-α][1,4]benzodiazepines show potent in vitro antifungal activity and significant in vivo efficacy in a Microsporum canis dermatitis model in guinea pigs.
Topics: Administration, Oral; Administration, Topical; Animals; Antifungal Agents; Azepines; Cell Line; Dermatomycoses; Disease Models, Animal; Guinea Pigs; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Microsporum; Pyrroles | 2014 |
Potential involvement of μ-opioid receptor dysregulation on the reduced antinociception of morphine in the inflammatory pain state in mice.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Indoles; Inflammation; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine; Pain; Phosphorylation; Protein Kinase C-alpha; Pyrroles; Receptors, Opioid, mu; Spinal Cord | 2014 |
Effects of single-dose atorvastatin on interleukin-6, interferon gamma, and myocardial no-reflow in a rabbit model of acute myocardial infarction and reperfusion.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Coronary Occlusion; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Heptanoic Acids; Immunohistochemistry; Inflammation; Interferon-gamma; Interleukin-6; Ligation; Male; Multivariate Analysis; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Necrosis; No-Reflow Phenomenon; Pyrroles; Rabbits; Random Allocation | 2014 |
The phosphoinositide 3-kinase α selective inhibitor BYL719 enhances the effect of the protein kinase C inhibitor AEB071 in GNAQ/GNA11-mutant uveal melanoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Silencing; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Melanoma; Mice; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrroles; Quinazolines; RNA Interference; Signal Transduction; Thiazoles; Tumor Burden; Uveal Neoplasms; Xenograft Model Antitumor Assays | 2014 |
Drug-induced suppression of ACTH secretion does not promote anti-depressive or anxiolytic effects.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Dose-Response Relationship, Drug; Indoles; Interpersonal Relations; Male; Maze Learning; Pyrimidines; Pyrroles; Pyrrolidines; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Swimming | 2014 |
Increased KIT inhibition enhances therapeutic efficacy in gastrointestinal stromal tumor.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Benzamides; Biopsy; Cell Survival; Disease Models, Animal; Drug Evaluation, Preclinical; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Inhibitory Concentration 50; Mice, Knockout; Molecular Targeted Therapy; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Tumor Burden | 2014 |
Probucol suppresses macrophage infiltration and MMP expression in atherosclerotic plaques of WHHL rabbits.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Cells, Cultured; Disease Models, Animal; Heptanoic Acids; Humans; Hyperlipoproteinemia Type II; Lipids; Macrophages; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Plaque, Atherosclerotic; Probucol; Pyrroles; Rabbits; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2014 |
T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration.
Topics: Animals; Biological Transport; Cyclosporine; Disease Models, Animal; Female; Humans; Immunization; Interferon-gamma; Interleukin-7; Macrophages; Macular Degeneration; Male; Mice; Oxidative Stress; Pyrroles; Retinal Pigment Epithelium; Sirolimus; T-Lymphocytes | 2014 |
Activity of anti-cancer protein kinase inhibitors against Leishmania spp.
Topics: Animals; Antineoplastic Agents; Antiprotozoal Agents; Disease Models, Animal; Drug Repositioning; Indoles; Inhibitory Concentration 50; Lapatinib; Leishmania; Leishmaniasis; Mice, Inbred BALB C; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Treatment Outcome | 2014 |
The relevance of testing the efficacy of anti-angiogenesis treatments on cells derived from primary tumors: a new method for the personalized treatment of renal cell carcinoma.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carcinoma, Renal Cell; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gene Expression; Humans; Indoles; Kidney Neoplasms; Mice; Molecular Targeted Therapy; Neoplasm Metastasis; Neoplasm Staging; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; Precision Medicine; Pyrroles; Receptor Protein-Tyrosine Kinases; Sorafenib; Sunitinib; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2014 |
Role of calcifying nanoparticle in the development of hyperplasia and vascular calcification in an animal model.
Topics: Angioplasty, Balloon; Animals; Atorvastatin; Calcifying Nanoparticles; Carotid Arteries; Carotid Artery Injuries; Carotid Intima-Media Thickness; Cholesterol; Disease Models, Animal; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperplasia; Male; Muscle, Smooth, Vascular; Neointima; Pyrroles; Rabbits; Time Factors; Triglycerides; Vascular Calcification | 2014 |
A TGF-β receptor 1 inhibitor for prevention of proliferative vitreoretinopathy.
Topics: Animals; Cell Proliferation; Cell Transdifferentiation; Disease Models, Animal; Fibroblasts; Humans; Intravitreal Injections; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Rabbits; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Retinal Pigment Epithelium; Tenon Capsule; Tetrazolium Salts; Thiazoles; Vitreoretinopathy, Proliferative | 2014 |
Atorvastatin ameliorates cardiac fibrosis and improves left ventricular diastolic function in hypertensive diastolic heart failure model rats.
Topics: Animals; Atorvastatin; Cells, Cultured; Disease Models, Animal; Fibroblasts; Fibrosis; Heart Failure, Diastolic; Heptanoic Acids; HSP47 Heat-Shock Proteins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Myocardium; Pyrroles; Rats; Rats, Inbred Dahl; rho-Associated Kinases; Ventricular Function, Left | 2014 |
Effects of atorvastatin on the inflammation regulation and elimination of subdural hematoma in rats.
Topics: Analysis of Variance; Animals; Atorvastatin; Blood Cell Count; Brain; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hematoma, Subdural; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Image Processing, Computer-Assisted; Inflammation; Lipids; Magnetic Resonance Imaging; Male; Neurologic Examination; Pyrroles; Rats; Rats, Wistar; Time Factors | 2014 |
SuHx rat model: partly reversible pulmonary hypertension and progressive intima obstruction.
Topics: Angiogenesis Inhibitors; Animals; Circadian Rhythm; Disease Models, Animal; Disease Progression; Echocardiography; Heart Ventricles; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Lung; Male; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Systole; Telemetry; Tunica Intima; Vascular Remodeling | 2014 |
Critical neuroprotective roles of heme oxygenase-1 induction against axonal injury-induced retinal ganglion cell death.
Topics: Animals; Axons; Disease Models, Animal; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation; Heme Oxygenase-1; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; Optic Nerve Injuries; Protoporphyrins; Pyrazines; Pyrroles; Retinal Ganglion Cells; Statistics, Nonparametric; Stilbamidines; Time Factors | 2014 |
Fas/Fas ligand mediates keratinocyte death in sunitinib-induced hand-foot skin reaction.
Topics: Administration, Oral; Animals; Apoptosis; Biomarkers; Biopsy; Cell Death; Cell Line, Tumor; Disease Models, Animal; Erythema; Fas Ligand Protein; fas Receptor; Female; Foot; Gene Expression Regulation; Hand; Humans; Indoles; Keratinocytes; Mice; Mice, Inbred C3H; Pyrroles; Sunitinib; Time Factors | 2014 |
Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection.
Topics: Animals; Capsid Proteins; Cats; Cell Line; Cell Survival; Disease Models, Animal; HIV Infections; Humans; Immunodeficiency Virus, Feline; Molecular Structure; Pyrroles; Small Molecule Libraries; Thiazines | 2014 |
Effectiveness of combination therapy of atorvastatin and non lipid-modifying tanshinone IIA from Danshen in a mouse model of atherosclerosis.
Topics: Abietanes; Animals; Atherosclerosis; Atorvastatin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drugs, Chinese Herbal; Heptanoic Acids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyrroles; Salvia miltiorrhiza; Treatment Outcome | 2014 |
Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Corticotropin-Releasing Hormone; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Hippocampus; Male; Memory; Mice; Mice, Transgenic; Neurons; Plaque, Amyloid; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Signal Transduction | 2014 |
Effects of the vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor SU5416 on in vitro cultures of Plasmodium falciparum.
Topics: Animals; Antimalarials; Cytosol; Disease Models, Animal; Erythrocytes; Female; Flow Cytometry; Humans; Immunohistochemistry; Indoles; Malaria; Mice, Inbred C57BL; Plasmodium berghei; Plasmodium falciparum; Pyrroles; Tyrosine; Vascular Endothelial Growth Factor Receptor-2 | 2014 |
Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; DNA-Binding Proteins; Dose-Response Relationship, Drug; Female; Gene Expression; Humans; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Pyrroles; Regulatory Factor X Transcription Factors; Regulatory Factor X1; Signal Transduction; STAT3 Transcription Factor; Transcription Factors; Triple Negative Breast Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
Direct and indirect protection of right ventricular function by estrogen in an experimental model of pulmonary arterial hypertension.
Topics: Animals; Arterial Pressure; Cardiotonic Agents; Compliance; Disease Models, Animal; Drug Implants; Estradiol; Estrogen Replacement Therapy; Estrogens; Female; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Mice, Inbred C57BL; Myocardial Contraction; Ovariectomy; Pulmonary Artery; Pyrroles; Stroke Volume; Time Factors; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right | 2014 |
Atorvastatin exerts anti-nociceptive activity and decreases serum levels of high-sensitivity C-reactive protein and tumor necrosis factor-α in a rat endometriosis model.
Topics: Analgesics; Animals; Atorvastatin; C-Reactive Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Endometriosis; Endometrium; Female; Heptanoic Acids; Humans; Leuprolide; Nociception; Nociceptive Pain; Pyrroles; Rats; Rats, Wistar; Treatment Outcome; Tumor Necrosis Factor-alpha | 2014 |
GluN2B N-methyl-D-aspartic acid receptor subunit mediates atorvastatin-Induced neuroprotection after focal cerebral ischemia.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Embryo, Mammalian; Heptanoic Acids; Male; Maze Learning; Nerve Tissue Proteins; Nervous System Diseases; Piperidines; Platelet Aggregation Inhibitors; Pyrroles; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recovery of Function; Somatosensory Cortex; Time Factors | 2014 |
NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling.
Topics: Adventitia; Animals; Antihypertensive Agents; Cell Movement; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Matrix; Familial Primary Pulmonary Hypertension; Fibroblasts; HEK293 Cells; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Monocrotaline; NADPH Oxidase 4; NADPH Oxidases; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Time Factors; Transfection; Up-Regulation | 2014 |
Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099).
Topics: Adenosine Triphosphatases; Amides; Animals; Anti-Bacterial Agents; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Knockout; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Pyrroles; Rats; Rats, Wistar; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles; Topoisomerase II Inhibitors | 2014 |
Intravesical TRPV4 blockade reduces repeated variate stress-induced bladder dysfunction by increasing bladder capacity and decreasing voiding frequency in male rats.
Topics: Administration, Intravesical; Animals; Disease Models, Animal; Gene Expression Regulation; Leucine; Male; Morpholines; Pyrroles; Rats; Rats, Wistar; RNA, Messenger; Sulfonamides; Time Factors; TRPV Cation Channels; Urinary Bladder; Urinary Bladder, Neurogenic; Urinary Incontinence, Stress; Urodynamics; Urological Agents | 2014 |
Effect of beta-3 adrenoceptor stimulation on the levels of ApoA-I, PPARα, and PPARγ in apolipoprotein E-deficient mice.
Topics: Adrenergic beta-3 Receptor Agonists; Adrenergic beta-3 Receptor Antagonists; Animals; Apolipoprotein A-I; Apolipoproteins E; Atherosclerosis; Atorvastatin; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Heptanoic Acids; Lipids; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; PPAR alpha; PPAR gamma; Pyrroles; Real-Time Polymerase Chain Reaction; Receptors, Adrenergic, beta-3; RNA, Messenger | 2014 |
Assessing treatment response of osteolytic lesions by manual volumetry, automatic segmentation, and RECIST in experimental bone metastases.
Topics: Algorithms; Animals; Antineoplastic Agents; Bone Density Conservation Agents; Bone Neoplasms; Cone-Beam Computed Tomography; Diphosphonates; Disease Models, Animal; Follow-Up Studies; Imidazoles; Indoles; Pyrroles; Radiographic Image Interpretation, Computer-Assisted; Rats; Rats, Nude; Reproducibility of Results; Sensitivity and Specificity; Sunitinib; Treatment Outcome; Zoledronic Acid | 2014 |
Evaluation of statin therapy on endothelial function in hypercholesterolemic rabbits by automatic measurement of arterial wall movement using ultrasound images.
Topics: Algorithms; Animals; Atorvastatin; Blood Flow Velocity; Disease Models, Animal; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Image Processing, Computer-Assisted; Male; Pyrroles; Rabbits; Ultrasonography, Doppler; Vasodilator Agents | 2014 |
Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antidepressive Agents; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Glycogen Synthase Kinase 3; Learning; Lithium Compounds; Long-Term Potentiation; Memory; Mice, Transgenic; Pyrroles; Quinolines; tau Proteins | 2014 |
Oral warfarin and the thrombin inhibitor dabigatran increase blood pressure in rats: hidden danger of anticoagulants?
Topics: Acetylcysteine; Animals; Anticoagulants; Antifibrinolytic Agents; Antithrombins; Benzimidazoles; beta-Alanine; Blood Pressure; Dabigatran; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; Nephrectomy; Pyrroles; Quinazolines; Rats; Receptor, PAR-1; Renal Insufficiency, Chronic; Vitamin K; Warfarin | 2015 |
SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1/SHP-1 activation in hepatocellular carcinoma.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; DNA-Binding Proteins; Drug Resistance, Neoplasm; Drug Synergism; Humans; Liver Neoplasms; Male; Mice; Niacinamide; Phenylurea Compounds; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Pyrroles; Regulatory Factor X Transcription Factors; Regulatory Factor X1; Sorafenib; STAT3 Transcription Factor; Transcription Factors; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2014 |
HspB8 expression in brain tissue after cerebral ischemic reperfusion and atorvastatin intervention in Sprague-Dawley rats.
Topics: Animals; Apoptosis; Atorvastatin; Blotting, Western; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Heat-Shock Proteins; Heptanoic Acids; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Pyrroles; Random Allocation; Rats, Sprague-Dawley; Reperfusion Injury; Severity of Illness Index; Tetrazolium Salts | 2015 |
Novel dual endothelin receptor antagonist macitentan reverses severe pulmonary arterial hypertension in rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indoles; Male; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Sulfonamides; Time Factors; Vascular Endothelial Growth Factor A | 2014 |
The effects of sunitinib on endometriosis.
Topics: Angiogenesis Inhibitors; Animals; Danazol; Disease Models, Animal; Endometriosis; Estrogen Antagonists; Female; Indoles; Peritoneal Diseases; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; Sunitinib; Tissue Adhesions | 2015 |
Effect of angiotensin II and small GTPase Ras signaling pathway inhibition on early renal changes in a murine model of obstructive nephropathy.
Topics: Angiotensin II; Animals; Atorvastatin; Disease Models, Animal; Fibrosis; Heptanoic Acids; Humans; Kidney; Kidney Diseases; Mice; Monomeric GTP-Binding Proteins; Pyrroles; Receptor, Angiotensin, Type 1; Signal Transduction; Ureteral Obstruction | 2014 |
Rosuvastatin activates ATP-binding cassette transporter A1-dependent efflux ex vivo and promotes reverse cholesterol transport in macrophage cells in mice fed a high-fat diet.
Topics: Animals; Apolipoprotein A-I; Atherosclerosis; Atorvastatin; ATP Binding Cassette Transporter 1; Biological Transport; Cell Line; Cholesterol Esters; Cholesterol, Dietary; Cholesterol, HDL; Cholesterol, VLDL; Diet, High-Fat; Disease Models, Animal; Dyslipidemias; Female; Fluorobenzenes; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Macrophages; Male; Mice; Mice, Inbred C57BL; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Sulfonamides; Time Factors | 2014 |
Inhibition of neointimal hyperplasia in rats treated with atorvastatin after carotid artery injury may be mainly associated with down-regulation of survivin and Fas expression.
Topics: Animals; Apoptosis; Atorvastatin; Carotid Artery Injuries; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; fas Receptor; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperplasia; In Situ Nick-End Labeling; Male; Microtubule-Associated Proteins; Muscle, Smooth, Vascular; Neointima; Pyrroles; Rats; Survivin | 2014 |
Transforming growth factor-β1 mediates psoriasis-like lesions via a Smad3-dependent mechanism in mice.
Topics: Animals; Disease Models, Animal; Humans; Interleukin-17; Interleukin-23; Interleukin-6; Isoquinolines; Mice; Mice, Transgenic; Ointments; Psoriasis; Pyridines; Pyrroles; Real-Time Polymerase Chain Reaction; Signal Transduction; Skin; Smad3 Protein; Transforming Growth Factor beta1 | 2014 |
Effects of dorsal periaqueductal gray CRF1- and CRF2-receptor stimulation in animal models of panic.
Topics: Animals; Anxiety; Behavior, Animal; Corticotropin-Releasing Hormone; Disease Models, Animal; Male; Microinjections; Panic; Periaqueductal Gray; Pyrimidines; Pyrroles; Rats; Receptors, Corticotropin-Releasing Hormone; Urocortins | 2014 |
The pharmacokinetics and hypoglycaemic effect of sunitinib in the diabetic rabbits.
Topics: Administration, Oral; Animals; Area Under Curve; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Hyperglycemia; Hypoglycemic Agents; Indoles; Male; Protein Kinase Inhibitors; Pyrroles; Rabbits; Sunitinib | 2014 |
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Halogenation; Hydrocarbons, Fluorinated; Male; Mice; Molecular Structure; Pentylenetetrazole; Pilocarpine; Pyrazines; Pyrroles; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship | 2014 |
Insights into the antiatherogenic molecular mechanisms of andrographolide against Porphyromonas gingivalis-induced atherosclerosis in rabbits.
Topics: Animals; Anti-Inflammatory Agents; Aorta; Atherosclerosis; Atorvastatin; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Heptanoic Acids; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Male; Plaque, Atherosclerotic; Porphyromonas gingivalis; Pyrroles; Rabbits; Vascular Cell Adhesion Molecule-1 | 2014 |
Treatment of hypertension and renal injury induced by the angiogenesis inhibitor sunitinib: preclinical study.
Topics: Acute Kidney Injury; Amlodipine; Angiogenesis Inhibitors; Animals; Blood Pressure; Disease Models, Animal; Drug Therapy, Combination; Endothelin A Receptor Antagonists; Follow-Up Studies; Glomerular Filtration Rate; Hypertension; Indoles; Pyrimidines; Pyrroles; Rats; Rats, Inbred WKY; Sulfonamides; Sunitinib; Treatment Outcome | 2014 |
JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.
Topics: Acute Disease; Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Enzyme Activation; Janus Kinase 1; Janus Kinase 3; Leukemia, T-Cell; Male; Mice; Mice, Inbred BALB C; Mutation; Piperidines; Pyrimidines; Pyrroles; Signal Transduction; T-Lymphocytes | 2014 |
Immunomodulatory effectiveness of licofelone in preventing epidural fibrosis in post-laminectomy rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cicatrix; Disease Models, Animal; Double-Blind Method; Epidural Space; Failed Back Surgery Syndrome; Fibrosis; Gene Expression; Hydroxyproline; Interleukin-6; Laminectomy; Lumbar Vertebrae; Male; Pyrroles; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Tissue Adhesions; Transforming Growth Factor beta1 | 2015 |
Disruption of ldlr causes increased LDL-c and vascular lipid accumulation in a zebrafish model of hypercholesterolemia.
Topics: Animals; Atorvastatin; Base Sequence; Blood Vessels; Cholesterol, LDL; Disease Models, Animal; Embryo, Nonmammalian; Gene Expression Regulation; Gene Knockdown Techniques; Hepatomegaly; Heptanoic Acids; Hypercholesterolemia; Liver; Molecular Sequence Data; Morpholinos; Oxidation-Reduction; Pyrroles; Receptors, LDL; Veins; Zebrafish | 2014 |
Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.
Topics: Animals; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Exons; Female; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Imidazoles; Indoles; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation; Mutation; Neoplasm Recurrence, Local; Piperazines; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridazines; Pyrimidines; Pyrroles; Sunitinib; Tomography, X-Ray Computed; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
Differential effects of atorvastatin on autophagy in ischemic and nonischemic myocardium in Ossabaw swine with metabolic syndrome.
Topics: Animals; Atorvastatin; Autophagy; Biomarkers; Cholesterol, Dietary; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Metabolic Syndrome; Myocardial Ischemia; Myocardium; Pyrroles; Signal Transduction; Swine | 2014 |
Modulation of enteric neurons by interleukin-6 and corticotropin-releasing factor contributes to visceral hypersensitivity and altered colonic motility in a rat model of irritable bowel syndrome.
Topics: Adolescent; Adult; Aged; Animals; Antibodies, Monoclonal; Case-Control Studies; Disease Models, Animal; Enteric Nervous System; Female; Gastrointestinal Motility; Humans; Interleukin-6; Irritable Bowel Syndrome; Male; Middle Aged; Myenteric Plexus; Neuroimmunomodulation; Neurosecretory Systems; Pain Threshold; Pyrimidines; Pyrroles; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Receptors, Interleukin-6; Visceral Pain; Young Adult | 2014 |
Pharmacologic inhibition of MLK3 kinase activity blocks the in vitro migratory capacity of breast cancer cells but has no effect on breast cancer brain metastasis in a mouse xenograft model.
Topics: Animals; Brain Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Female; MAP Kinase Kinase Kinases; Mice; Mice, Nude; Mitogen-Activated Protein Kinase Kinase Kinase 11; Neoplasm Transplantation; Protein Kinase Inhibitors; Pyridines; Pyrroles; Transplantation, Heterologous | 2014 |
TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.
Topics: Animals; Butadienes; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fixatives; Formaldehyde; Keratinocytes; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Neurons; Nitriles; Pain; Pyrroles; Trigeminal Ganglion; TRPV Cation Channels; Ubiquitin Thiolesterase; Vibrissae | 2014 |
L-745,870 reduces the expression of abnormal involuntary movements in the 6-OHDA-lesioned rat.
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Female; Levodopa; Oxidopamine; Parkinsonian Disorders; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Species Specificity | 2015 |
Effect of atorvastatin on the expression of gamma-glutamyl transferase in aortic atherosclerotic plaques of apolipoprotein E-knockout mice.
Topics: Animals; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Atorvastatin; Cholesterol, Dietary; Diet, High-Fat; Disease Models, Animal; Down-Regulation; gamma-Glutamyltransferase; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Intercellular Adhesion Molecule-1; Male; Mice, Inbred C57BL; Mice, Knockout; Plaque, Atherosclerotic; Pyrroles; Time Factors; Vascular Cell Adhesion Molecule-1 | 2014 |
Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension.
Topics: Animals; Apelin; Arterioles; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelial Cells; Fibroblast Growth Factor 2; Hemodynamics; Histone Deacetylase Inhibitors; Hydroxamic Acids; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Intercellular Signaling Peptides and Proteins; Male; MEF2 Transcription Factors; MicroRNAs; Monocrotaline; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Transcription, Genetic | 2015 |
Lack of involvement of CEP adducts in TLR activation and in angiogenesis.
Topics: Animals; Choroidal Neovascularization; Disease Models, Animal; HEK293 Cells; Humans; Lasers; Leukocytes; Mice, Inbred C57BL; Neovascularization, Pathologic; Pyrroles; Retina; Toll-Like Receptor 2 | 2014 |
Activation of TRPV4 channels does not mediate inversion of neurovascular coupling after SAH.
Topics: Animals; Astrocytes; Calcium Signaling; Disease Models, Animal; Hyperemia; Male; Morpholines; Organ Culture Techniques; Pyrroles; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; TRPV Cation Channels | 2015 |
Activation of Transient Receptor Potential Vanilloid 4 is Involved in Neuronal Injury in Middle Cerebral Artery Occlusion in Mice.
Topics: Animals; Disease Models, Animal; Hippocampus; Infarction, Middle Cerebral Artery; Male; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Pyrroles; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; TRPV Cation Channels | 2016 |
Stress during a critical postnatal period induces region-specific structural abnormalities and dysfunction of the prefrontal cortex via CRF1.
Topics: Animals; Animals, Newborn; Anxiety Disorders; Cognition Disorders; Dendritic Spines; Disease Models, Animal; Female; Hormone Antagonists; Male; Mice, Inbred C57BL; Prefrontal Cortex; Pyramidal Cells; Pyrimidines; Pyrroles; Random Allocation; Receptors, Corticotropin-Releasing Hormone; Stress, Psychological | 2015 |
The effect of chronic stress on anti-angiogenesis of sunitinib in colorectal cancer models.
Topics: Adrenergic alpha-Agonists; Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Chronic Disease; Colorectal Neoplasms; Disease Models, Animal; Female; Humans; Indoles; Interleukin-8; Mice; Mice, Inbred BALB C; Norepinephrine; Pyrroles; Receptors, Adrenergic, beta; Signal Transduction; Stress, Psychological; Sunitinib; Vascular Endothelial Growth Factor A | 2015 |
Tissue specific up regulation of ACE2 in rabbit model of atherosclerosis by atorvastatin: role of epigenetic histone modifications.
Topics: Angiotensin-Converting Enzyme 2; Animals; Atherosclerosis; Atorvastatin; Disease Models, Animal; Epigenesis, Genetic; Heptanoic Acids; Histones; Male; Peptidyl-Dipeptidase A; Pyrroles; Rabbits; Tissue Distribution; Up-Regulation | 2015 |
Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke.
Topics: Animals; Brain; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibrosis; Gene Expression Regulation; Indoles; Infarction, Middle Cerebral Artery; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Pericytes; Pyrroles; Rats; Receptor, Platelet-Derived Growth Factor beta; RNA, Messenger; Time Factors | 2015 |
Atorvastatin regulates apoptosis in chronically ischemic myocardium.
Topics: Animals; Apoptosis; Atorvastatin; bcl-2-Associated X Protein; Caspase 3; Chronic Disease; Disease Models, Animal; Gene Expression Regulation, Developmental; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; MAP Kinase Signaling System; Metabolic Syndrome; Myocardial Ischemia; Myocardium; Neovascularization, Pathologic; Pyrroles; Swine; Swine, Miniature | 2015 |
Prostatic angiogenic responses in late life: antiangiogenic therapy influences and relation with the glandular microenvironment in the transgenic adenocarcinoma of mouse prostate (TRAMP) model.
Topics: 5-alpha Reductase Inhibitors; Adenocarcinoma; Angiogenesis Inhibitors; Animals; Blotting, Western; Cyclohexanes; Disease Models, Animal; Endostatins; Fibroblast Growth Factor 2; Finasteride; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Indoles; Male; Mice; Mice, Transgenic; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Prostatic Neoplasms; Pyrroles; Sesquiterpenes; Tumor Microenvironment; Vascular Endothelial Growth Factor A | 2015 |
Role of inflammation in the initiation and maintenance of atrial fibrillation and the protective effect of atorvastatin in a goat model of aseptic pericarditis.
Topics: Animals; Atorvastatin; Atrial Fibrillation; Cardiac Surgical Procedures; Cytokines; Disease Models, Animal; Goats; Heart Atria; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Inflammation Mediators; Male; Pericarditis; Pyrroles | 2015 |
Protection effect of atorvastatin in cerebral ischemia-reperfusion injury rats by blocking the mitochondrial permeability transition pore.
Topics: Animals; Anticholesteremic Agents; Apoptosis; Atorvastatin; Brain Ischemia; Cytochromes c; Disease Models, Animal; Heptanoic Acids; Infarction, Middle Cerebral Artery; Male; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Pyrroles; Rats, Sprague-Dawley; Reperfusion Injury | 2014 |
Pyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Female; Hematologic Neoplasms; Humans; Models, Molecular; Molecular Conformation; Myeloid Cell Leukemia Sequence 1 Protein; Phenols; Protein Binding; Protein Interaction Domains and Motifs; Proteolysis; Pyrroles; Stromal Cells; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
Rheumatoid arthritis in 2014: Exciting times for RA research.
Topics: Animals; Arthritis, Rheumatoid; Disease Models, Animal; Humans; Inflammation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; T-Lymphocytes, Regulatory | 2015 |
β2 adrenergic receptor activation governs cardiac repolarization and arrhythmogenesis in a guinea pig model of heart failure.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Amrinone; Animals; Arrhythmias, Cardiac; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Electric Stimulation; Electrocardiography; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Guinea Pigs; Heart Failure; In Vitro Techniques; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Pyrroles; Receptors, Adrenergic, beta-2; Thionucleotides; Ventricular Function | 2015 |
Repositioning Potential of PAK4 to Osteoclastic Bone Resorption.
Topics: Animals; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Disease Models, Animal; Humans; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Osteoclasts; p21-Activated Kinases; Pyrazoles; Pyrroles | 2015 |
Host-based Prophylaxis Successfully Targets Liver Stage Malaria Parasites.
Topics: Animals; Antimalarials; Cell Line; Disease Models, Animal; Female; Imidazoles; Indoles; Life Cycle Stages; Liver; Malaria; Malaria, Falciparum; Mice; Mice, Transgenic; Parasite Load; Piperazines; Plasmodium; Plasmodium falciparum; Post-Exposure Prophylaxis; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Tumor Suppressor Protein p53 | 2015 |
Neuroprotective effect of atorvastatin in spinal cord ischemia-reperfusion injury.
Topics: Animals; Atorvastatin; Biopsy; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Malondialdehyde; Neuroprotective Agents; Nitric Oxide; Paraplegia; Pyrroles; Rabbits; Random Allocation; Reperfusion Injury; Reproducibility of Results; Spinal Cord Ischemia; Superoxide Dismutase; Time Factors | 2015 |
Discovery of 7-azaindole derivatives as potent Orai inhibitors showing efficacy in a preclinical model of asthma.
Topics: Animals; Asthma; Aza Compounds; Calcium Channel Blockers; Calcium Channels; Disease Models, Animal; Drug Evaluation, Preclinical; Half-Life; Humans; Hypersensitivity; Indoles; Interleukin-2; Jurkat Cells; Microsomes; Models, Biological; Ovalbumin; Protein Binding; Pyridines; Pyrroles; Rats; Structure-Activity Relationship | 2015 |
Therapeutic effect of sunitinib on diabetes mellitus related ovarian injury: an experimental rat model study.
Topics: Angiogenesis Inhibitors; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Fibrosis; Immunohistochemistry; Indoles; NF-kappa B; Ovary; Primary Ovarian Insufficiency; Pyrroles; Rats; Sunitinib | 2015 |
Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Calcium; Disease Models, Animal; Gene Knockout Techniques; Guanidines; HEK293 Cells; Humans; Inflammation; Macrophages, Peritoneal; Male; Melanins; Melanoma, Experimental; Mice; Neutrophils; Peritonitis; Phagocytosis; Pyrroles; Receptor, Melanocortin, Type 1; Receptor, Melanocortin, Type 3; Receptors, Melanocortin; Signal Transduction | 2015 |
Successful combination of sunitinib and girentuximab in two renal cell carcinoma animal models: a rationale for combination treatment of patients with advanced RCC.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cell Line, Tumor; Disease Models, Animal; Female; Heterografts; Humans; Indoles; Kidney Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Pyrroles; Real-Time Polymerase Chain Reaction; Sunitinib | 2015 |
Angiostatic treatment prior to chemo- or photodynamic therapy improves anti-tumor efficacy.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Axitinib; Cell Line, Tumor; Chick Embryo; Combined Modality Therapy; Cymenes; Disease Models, Animal; Doxorubicin; Drug Synergism; Humans; Imidazoles; Indazoles; Indoles; Neoplasms; Neovascularization, Pathologic; Organometallic Compounds; Oxygen Consumption; Photochemotherapy; Protein Kinase Inhibitors; Pyrroles; Sunitinib; Tumor Burden | 2015 |
The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models.
Topics: Animals; Antineoplastic Agents; Carcinoma, Papillary; Carcinoma, Renal Cell; Cell Line, Tumor; Crizotinib; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Indoles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyrazines; Pyrazoles; Pyridines; Pyrroles; Sunitinib; Triazines; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Optimal treatment scheduling of ionizing radiation and sunitinib improves the antitumor activity and allows dose reduction.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Humans; Indoles; Neovascularization, Pathologic; Pyrroles; Radiation Dosage; Radiation, Ionizing; Sunitinib; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Delayed inhibition of VEGF signaling after stroke attenuates blood-brain barrier breakdown and improves functional recovery in a comorbidity-dependent manner.
Topics: Animals; Blood-Brain Barrier; Brain; Capillaries; Dendritic Spines; Diabetes Mellitus, Experimental; Disease Models, Animal; Endothelial Cells; Gene Expression; Indoles; Infarction; Insulin; Mice; Permeability; Pyrroles; Recovery of Function; Signal Transduction; Stroke; Synapses; Transcytosis; Vascular Endothelial Growth Factor Receptor-2 | 2015 |
Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.
Topics: Aminopyridines; Animals; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Glycogen Synthase Kinase 3; Humans; Mice; Mice, Transgenic; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Pyridones; Pyrroles; Structure-Activity Relationship | 2015 |
Long-term effects of early adolescent stress: dysregulation of hypothalamic-pituitary-adrenal axis and central corticotropin releasing factor receptor 1 expression in adult male rats.
Topics: Animals; Anxiety; Corticosterone; Depression; Disease Models, Animal; Electroshock; Exercise Therapy; Foot; Hypothalamo-Hypophyseal System; Male; Maze Learning; Pituitary-Adrenal System; Pyrimidines; Pyrroles; Random Allocation; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Running; Stress Disorders, Post-Traumatic; Stress, Psychological | 2015 |
Therapeutic Peptide Vaccine-Induced CD8 T Cells Strongly Modulate Intratumoral Macrophages Required for Tumor Regression.
Topics: Aminopyridines; Animals; Cancer Vaccines; CD8-Positive T-Lymphocytes; Cell Movement; Chemokines; Disease Models, Animal; Female; Lymphocytes, Tumor-Infiltrating; Macrophages; Mice, Inbred C57BL; Myeloid Cells; Ovarian Neoplasms; Protein-Tyrosine Kinases; Pyrroles; Vaccines, Subunit | 2015 |
The Suppression of Wound Healing Response with Sirolimus and Sunitinib Following Experimental Trabeculectomy in a Rabbit Model.
Topics: Alkylating Agents; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Fibroblast Growth Factor 2; Fibroblast Growth Factors; Immunosuppressive Agents; Indoles; Male; Mitomycin; Platelet-Derived Growth Factor; Pyrroles; Rabbits; Sirolimus; Sunitinib; Trabecular Meshwork; Trabeculectomy; Transforming Growth Factor beta; Wound Healing | 2016 |
Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Arachidonic Acid; Carcinoma in Situ; Carcinoma, Pancreatic Ductal; Cell Proliferation; Ceruletide; Cyclooxygenase 2; Disease Models, Animal; Disease Progression; Doublecortin-Like Kinases; Lipoxygenase Inhibitors; Mice; Mice, Knockout; MicroRNAs; Neoplastic Stem Cells; Pancreatic Neoplasms; Pancreatitis; Protein Serine-Threonine Kinases; Pyrroles | 2015 |
MicroRNA-208a Increases Myocardial Endoglin Expression and Myocardial Fibrosis in Acute Myocardial Infarction.
Topics: Animals; Atorvastatin; Blotting, Western; Cells, Cultured; Disease Models, Animal; Endoglin; Fibrosis; Gene Expression Regulation; Hemodynamics; Heptanoic Acids; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; MicroRNAs; Muscle Cells; Myocardial Infarction; Polymerase Chain Reaction; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Tetrazoles; Valine; Valsartan; Ventricular Remodeling | 2015 |
Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model.
Topics: Animals; Base Sequence; Binding Sites; Callithrix; Cicatrix, Hypertrophic; Disease Models, Animal; Gene Silencing; Gene Targeting; Humans; Imidazoles; Injections; Male; Molecular Sequence Data; Nylons; Ointments; Promoter Regions, Genetic; Pyrroles; RNA, Messenger; Transforming Growth Factor beta1 | 2015 |
Effects of Pazopanib, Sunitinib, and Sorafenib, Anti-VEGF Agents, on the Growth of Experimental Endometriosis in Rats.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Proliferation; Disease Models, Animal; Endometriosis; Endometrium; Female; Indazoles; Indoles; Niacinamide; Ovarian Reserve; Phenylurea Compounds; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Rats, Wistar; Signal Transduction; Sorafenib; Sulfonamides; Sunitinib; Vascular Endothelial Growth Factor A | 2015 |
Receptor-Mediated Mechanism Controlling Tissue Levels of Bioactive Lipid Oxidation Products.
Topics: Animals; Antigens, Differentiation; Apolipoproteins E; Atherosclerosis; CD36 Antigens; Disease Models, Animal; HEK293 Cells; Humans; Lipoproteins, LDL; Macrophages, Peritoneal; Melanoma, Experimental; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Physiologic; Oxidative Stress; Phenotype; Pyrroles; RNA Interference; Signal Transduction; Time Factors; Toll-Like Receptor 2; Transfection; Tumor Burden; Wound Healing | 2015 |
The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis.
Topics: Alcohol Oxidoreductases; Animals; Antitubercular Agents; Bacterial Proteins; Catalytic Domain; Disease Models, Animal; Hep G2 Cells; Humans; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Piperazines; Pyridines; Pyrroles; Spiro Compounds; Structure-Activity Relationship; Thiazines; Tuberculosis | 2015 |
Targeting cells of the myeloid lineage attenuates pain and disease progression in a prostate model of bone cancer.
Topics: Aminopyridines; Analgesics; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bone and Bones; Bone Neoplasms; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Dogs; Formaldehyde; Male; Mice; Mice, Nude; Neoplasm Transplantation; Pain; Pain Measurement; Prostatic Neoplasms; Protein Kinases; Pyrroles; Rats; Rats, Sprague-Dawley | 2015 |
The hypolipidemic effect of artesunate and ursolic acid in rats.
Topics: Animals; Artemisinins; Artesunate; Atorvastatin; Cholesterol; Disease Models, Animal; Heptanoic Acids; Hyperlipidemias; Hypolipidemic Agents; Pyrroles; Rats; Triglycerides; Triterpenes; Ursolic Acid | 2015 |
Pharmacological profile of CS-3150, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist.
Topics: Administration, Oral; Adrenalectomy; Aldosterone; Animals; Antihypertensive Agents; Binding, Competitive; Blood Pressure; Desoxycorticosterone Acetate; Disease Models, Animal; Dose-Response Relationship, Drug; Eplerenone; Female; HEK293 Cells; Humans; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Potassium; Protein Binding; Pyrroles; Rabbits; Radioligand Assay; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Sodium; Spironolactone; Sulfones; Transcriptional Activation; Transfection; Urological Agents; Water-Electrolyte Balance | 2015 |
Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration.
Topics: alpha-Synuclein; Animals; Antiparkinson Agents; Dependovirus; Disease Models, Animal; Female; Gene Expression Regulation; Genetic Vectors; Humans; Injections, Intraventricular; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Parkinson Disease; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction; Substantia Nigra | 2015 |
An examination of the cardiac actions of PD117,302, a κ-opioid receptor agonist.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Binding, Competitive; Cardiac Pacing, Artificial; Cerebellum; Coronary Occlusion; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Guinea Pigs; Heart Conduction System; Heart Rate; Heart Ventricles; Isolated Heart Preparation; Ligands; Male; Mice, Inbred BALB C; Myocardial Contraction; Pain; Pain Threshold; Potassium Channel Blockers; Potassium Channels; Protein Binding; Pyrroles; Radioligand Assay; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sodium Channel Blockers; Sodium Channels; Thiophenes; Ventricular Function, Left; Ventricular Pressure | 2015 |
Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model.
Topics: Animals; Antipsychotic Agents; Cognition; Disease Models, Animal; Long-Term Synaptic Depression; Male; Mice, Inbred C57BL; Mice, Knockout; Patch-Clamp Techniques; Phencyclidine; Pyridines; Pyrroles; Receptor, Muscarinic M1; Schizophrenia; Schizophrenic Psychology; Social Behavior | 2016 |
AKT Antagonist AZD5363 Influences Estrogen Receptor Function in Endocrine-Resistant Breast Cancer and Synergizes with Fulvestrant (ICI182780) In Vivo.
Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cluster Analysis; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Estradiol; Female; Fulvestrant; Gene Expression Profiling; Humans; Mice; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Pyrimidines; Pyrroles; Receptors, Estrogen; Signal Transduction; TOR Serine-Threonine Kinases; Transcriptional Activation; Xenograft Model Antitumor Assays | 2015 |
Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus.
Topics: Aminopyridines; Animals; Behavioral Symptoms; Blood-Brain Barrier; Brain Injuries; Cognition Disorders; Dendritic Spines; Disease Models, Animal; Doxycycline; Female; Hippocampus; Male; Maze Learning; Mice; Mice, Transgenic; Microglia; Neurons; Phosphopyruvate Hydratase; Pyrroles; Recovery of Function; Synaptophysin | 2015 |
Topically Administered Janus-Kinase Inhibitors Tofacitinib and Oclacitinib Display Impressive Antipruritic and Anti-Inflammatory Responses in a Model of Allergic Dermatitis.
Topics: Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents; Antipruritics; Cytokines; Dermatitis, Allergic Contact; Disease Models, Animal; Female; Inflammation; Janus Kinases; Lymph Nodes; Mice; Mice, Inbred BALB C; Piperidines; Pruritus; Pyrimidines; Pyrroles; Skin; Sulfonamides | 2015 |
Aggression behaviour induced by oral administration of the Janus-kinase inhibitor tofacitinib, but not oclacitinib, under stressful conditions.
Topics: Administration, Oral; Aggression; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Behavior, Animal; Brain; Dermatitis, Atopic; Disease Models, Animal; Female; Janus Kinases; Male; Mice, Inbred BALB C; Piperidines; Protein Kinase Inhibitors; Pruritus; Pyrimidines; Pyrroles; Stress, Psychological; Sulfonamides; Toluene 2,4-Diisocyanate | 2015 |
HIF-1 Dimerization Inhibitor Acriflavine Enhances Antitumor Activity of Sunitinib in Breast Cancer Model.
Topics: Acriflavine; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Drug Synergism; Female; Hypoxia-Inducible Factor 1; Indoles; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Myeloid Cells; Necrosis; Neovascularization, Pathologic; Protein Multimerization; Pyrroles; Spleen; Sunitinib; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A | 2014 |
Invasiveness and metastasis of retinoblastoma in an orthotopic zebrafish tumor model.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Heterografts; Humans; Indoles; Mice; Morpholinos; Neoplasm Invasiveness; Neoplasm Metastasis; Neovascularization, Pathologic; Pyrroles; Retinoblastoma; Sunitinib; Vascular Endothelial Growth Factor A; Zebrafish | 2015 |
The effect of obestatin on anxiety-like behaviour in mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Corticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Exploratory Behavior; Ghrelin; Male; Maze Learning; Mice; Oligopeptides; Pyrimidines; Pyrroles | 2015 |
Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications.
Topics: alpha-Synuclein; Animals; Brain; Disease Models, Animal; Enzyme Inhibitors; Humans; Male; Mice, Transgenic; Microglia; Motor Activity; Multiple System Atrophy; Myelin Proteolipid Protein; Neurons; Neuroprotective Agents; Nitro Compounds; Peroxidase; Propionates; Pyrimidinones; Pyrroles; Severity of Illness Index; Treatment Outcome | 2015 |
Monitoring therapeutic efficacy of sunitinib using [(18)F]FDG and [(18)F]FMISO PET in an immunocompetent model of luminal B (HER2-positive)-type mammary carcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Proliferation; Disease Models, Animal; Female; Fluorodeoxyglucose F18; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Mice; Misonidazole; Positron-Emission Tomography; Pyrroles; Sunitinib | 2015 |
Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury.
Topics: Acute Lung Injury; Animals; Bone Marrow Transplantation; Calcium Signaling; Capillary Permeability; Disease Models, Animal; Humans; Hydrochloric Acid; Lung; Male; Mice, Knockout; Morpholines; Neutrophil Activation; Neutrophils; Pneumonia; Pulmonary Edema; Pyrroles; TRPV Cation Channels | 2016 |
Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim.
Topics: Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Line, Tumor; Disease Models, Animal; Doxorubicin; Drug Synergism; Humans; Indoles; Lymphoma; Membrane Proteins; Mice; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins; Pyrroles; Xenograft Model Antitumor Assays | 2015 |
Synergistic antitumor responses by combined GITR activation and sunitinib in metastatic renal cell carcinoma.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; CD8-Positive T-Lymphocytes; Disease Models, Animal; Drug Synergism; Female; Glucocorticoid-Induced TNFR-Related Protein; Immunotherapy; Indoles; Kidney Neoplasms; Killer Cells, Natural; Lymphocyte Activation; Macrophage Activation; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrroles; Sunitinib | 2016 |
A model of neuropathic pain induced by sorafenib in the rat: Effect of dimiracetam.
Topics: Analgesics; Analysis of Variance; Animals; Antineoplastic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Imidazoles; Male; Neuralgia; Niacinamide; Pain Measurement; Pain Threshold; Phenylurea Compounds; Pyrroles; Rats; Rats, Sprague-Dawley; Reaction Time; Sorafenib; Time Factors | 2015 |
Oral Platelet-Derived Growth Factor and Vascular Endothelial Growth Factor Inhibitor Sunitinib Prevents Chronic Allograft Injury in Experimental Kidney Transplantation Model.
Topics: Administration, Oral; Allografts; Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Graft Rejection; Indoles; Kidney; Kidney Transplantation; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Pyrroles; Rats, Wistar; Signal Transduction; Sunitinib; Time Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor B; Vascular Endothelial Growth Factors | 2016 |
Marked Strain-Specific Differences in the SU5416 Rat Model of Severe Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Pyrroles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Sprague-Dawley; Species Specificity | 2016 |
Lifelong disturbance of serotonin transporter functioning results in fear learning deficits: Reversal by blockade of CRF1 receptors.
Topics: Animals; Basolateral Nuclear Complex; Disease Models, Animal; Dorsal Raphe Nucleus; Fear; Gene Knockout Techniques; Learning; Learning Disabilities; Male; Neurotransmitter Agents; Paroxetine; Prepulse Inhibition; Pyrimidines; Pyrroles; Rats, Transgenic; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Reflex, Startle; RNA-Binding Proteins; RNA, Messenger | 2015 |
Involvement of Mast Cells in α7 Nicotinic Receptor Agonist Exacerbation of Freund's Complete Adjuvant-Induced Monoarthritis in Mice.
Topics: Aconitine; Adjuvants, Immunologic; alpha7 Nicotinic Acetylcholine Receptor; Animals; Apolipoproteins E; Arthritis, Experimental; Bridged-Ring Compounds; Cell Movement; Cell Proliferation; Disease Models, Animal; Disease Progression; Freund's Adjuvant; Inflammation; Injections, Intra-Articular; Lipopolysaccharides; Male; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nicotinic Antagonists; Peptide Fragments; Pyrroles; Spiro Compounds; Xanthones | 2016 |
Preclinical Evidence for the Use of Sunitinib Malate in the Treatment of Plexiform Neurofibromas.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Proliferation; Disease Models, Animal; Female; Fibroblasts; Indoles; Male; Mast Cells; Mice; Mice, Transgenic; Neurofibroma, Plexiform; Positron-Emission Tomography; Pyrroles; Sunitinib; Tumor Microenvironment | 2016 |
Activation of Src-dependent Smad3 signaling mediates the neutrophilic inflammation and oxidative stress in hyperoxia-augmented ventilator-induced lung injury.
Topics: Animals; Capillary Permeability; Chemokine CXCL2; Disease Models, Animal; Genetic Predisposition to Disease; Hyperoxia; Isoquinolines; Lung; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Neutrophil Infiltration; Neutrophils; Oxidative Stress; Phenotype; Pneumonia; Pyridines; Pyrroles; Respiration, Artificial; Signal Transduction; Smad3 Protein; src-Family Kinases; Tidal Volume; Ventilator-Induced Lung Injury | 2015 |
Efficacy of Adjunctive Tofacitinib Therapy in Mouse Models of Tuberculosis.
Topics: Animals; Cytokines; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred BALB C; Piperidines; Pyrimidines; Pyrroles; Tuberculosis | 2015 |
Glutathione Deficit Affects the Integrity and Function of the Fimbria/Fornix and Anterior Commissure in Mice: Relevance for Schizophrenia.
Topics: Animals; Brain; Diffusion Tensor Imaging; Disease Models, Animal; Glutamate-Cysteine Ligase; Glutathione; Male; Mice, Knockout; Organ Size; Pyrroles; Schizophrenia; Tissue Culture Techniques; White Matter | 2015 |
Role of Janus Kinase 3 in Predisposition to Obesity-associated Metabolic Syndrome.
Topics: Animals; Body Weight; Caco-2 Cells; Cytokines; Diet, High-Fat; Disease Models, Animal; Genetic Predisposition to Disease; Glucose Tolerance Test; Humans; Immunity, Innate; Inflammation; Insulin; Janus Kinase 3; Liver; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; Obesity; Organ Size; Piperidines; Pyrimidines; Pyrroles; Risk Factors; Signal Transduction; Toll-Like Receptors | 2015 |
Janus Kinase Inhibitor Tofacitinib Shows Potent Efficacy in a Mouse Model of Autoimmune Lymphoproliferative Syndrome (ALPS).
Topics: Animals; Autoimmune Lymphoproliferative Syndrome; Disease Models, Animal; fas Receptor; Humans; Immunoglobulins; Janus Kinase 3; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Mutation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory | 2015 |
Cyclooxygenase-2 Inhibition Provides Lasting Protection Following Germinal Matrix Hemorrhage in Premature Infant Rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Blotting, Western; Brain; Cyclooxygenase 2; Disease Models, Animal; Intracranial Hemorrhages; Oligopeptides; Pyrroles; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, PAR-1; Receptors, Thrombin | 2016 |
The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats.
Topics: Animals; Avoidance Learning; Benzothiazoles; Cholinesterase Inhibitors; Disease Models, Animal; Dizocilpine Maleate; Donepezil; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Histamine H3 Antagonists; Indans; Male; Memory; Memory Disorders; Nootropic Agents; Phenoxypropanolamines; Piperidines; Pyrilamine; Pyrroles; Quinazolines; Random Allocation; Rats, Wistar; Receptors, Histamine H3 | 2016 |
Alcohol and high fat induced chronic pancreatitis: TRPV4 antagonist reduces hypersensitivity.
Topics: Analgesics; Animals; Diet, High-Fat; Disease Models, Animal; Drug Evaluation, Preclinical; Ethanol; Hot Temperature; Loperamide; Male; Morpholines; Oxidative Stress; Pain; Pain Threshold; Pancreatitis, Chronic; Pyrroles; Random Allocation; Rats, Inbred F344; Receptors, Opioid, mu; Touch; TRPV Cation Channels | 2015 |
Preclinical Evidence That Trametinib Enhances the Response to Antiangiogenic Tyrosine Kinase Inhibitors in Renal Cell Carcinoma.
Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Renal Cell; Cell Line, Tumor; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Drug Synergism; Endothelial Cells; Female; Humans; Indoles; Kidney Neoplasms; MAP Kinase Signaling System; Neovascularization, Pathologic; Protein Kinase Inhibitors; Pyridones; Pyrimidinones; Pyrroles; Sunitinib; Von Hippel-Lindau Tumor Suppressor Protein; Xenograft Model Antitumor Assays | 2016 |
Prodrug AST-003 Improves the Therapeutic Index of the Multi-Targeted Tyrosine Kinase Inhibitor Sunitinib.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Benzoates; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Synergism; Drug Tolerance; Esterases; Female; Humans; Hydrolysis; Indoles; Mice; Neoplasms; Phosphorylation; Prodrugs; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrroles; STAT3 Transcription Factor; Sunitinib; Tissue Distribution; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Stress activates the nucleus incertus and modulates plasticity in the hippocampo-medial prefrontal cortical pathway.
Topics: Animals; Brain Stem; Catheters, Indwelling; Cold Temperature; Disease Models, Animal; Electrodes, Implanted; Fluorescent Antibody Technique; Hippocampus; Long-Term Potentiation; Male; Neural Pathways; Neurons; Neurotransmitter Agents; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Stress, Psychological; Swimming | 2016 |
Discovery of Novel ROCK1 Inhibitors via Integrated Virtual Screening Strategy and Bioassays.
Topics: Actin Depolymerizing Factors; Amides; Animals; Atorvastatin; Binding Sites; Cerebral Hemorrhage; Databases, Chemical; Databases, Protein; Disease Models, Animal; Enzyme Activation; Human Umbilical Vein Endothelial Cells; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Phosphorylation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyridines; Pyrroles; rho-Associated Kinases; Signal Transduction; Structure-Activity Relationship; Zebrafish | 2015 |
Possible involvement of basic FGF in the upregulation of PDGFRβ in pericytes after ischemic stroke.
Topics: Animals; Brain; Brain Ischemia; Cell Hypoxia; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Fibroblast Growth Factor 2; Humans; Hydrogen-Ion Concentration; Infarction, Middle Cerebral Artery; Male; Mice, 129 Strain; Mice, Inbred C57BL; Pericytes; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Receptors, Fibroblast Growth Factor; Stroke; Up-Regulation | 2016 |
Berberine is a dopamine D1- and D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses.
Topics: Adaptive Immunity; Animals; Benzazepines; Berberine; Bone Marrow; Colitis; Cytokines; Dendritic Cells; Dextran Sulfate; Disease Models, Animal; Dopamine Antagonists; Immunity, Innate; Lipopolysaccharides; Lymph Nodes; Lymphocytes; Macrophages; Mice; Mice, Inbred C57BL; Protein Binding; Pyridines; Pyrroles; Receptors, Dopamine; Receptors, Serotonin; Time Factors | 2015 |
Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cyclohexylamines; Disease Models, Animal; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immunophenotyping; Intracellular Signaling Peptides and Proteins; Janus Kinases; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Syk Kinase | 2015 |
Marizomib activity as a single agent in malignant gliomas: ability to cross the blood-brain barrier.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Cell Line, Tumor; Disease Models, Animal; Glioma; Lactones; Mice, Inbred BALB C; Mice, Nude; Proteasome Inhibitors; Pyrroles | 2016 |
Anti-inflammatory effect of topical administration of tofacitinib on corneal inflammation.
Topics: Administration, Topical; Animals; Cells, Cultured; Cornea; Corneal Neovascularization; Disease Models, Animal; Janus Kinase 3; Keratitis; Male; Mice; Mice, Inbred BALB C; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2016 |
Effects of Dopamine D2-Like Receptor Antagonists on Light Responses of Ganglion Cells in Wild-Type and P23H Rat Retinas.
Topics: Action Potentials; Animals; Disease Models, Animal; Dopamine D2 Receptor Antagonists; Light; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Retinal Ganglion Cells; Retinitis Pigmentosa; Salicylamides; Sulpiride | 2015 |
Does angiogenesis play a role in the establishment of mesial temporal lobe epilepsy?
Topics: Angiogenesis Inhibitors; Animals; Cell Count; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Indoles; Lectins; Male; Neovascularization, Pathologic; Pilocarpine; Pyrroles; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Sunitinib; Time Factors | 2016 |
Prevention of Venous Neointimal Hyperplasia by a Multitarget Receptor Tyrosine Kinase Inhibitor.
Topics: Animals; Arteriovenous Shunt, Surgical; Becaplermin; Blood Vessel Prosthesis Implantation; Carotid Artery, Common; Cell Cycle Proteins; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Female; Graft Occlusion, Vascular; Humans; Hyperplasia; Indoles; Jugular Veins; Myocytes, Smooth Muscle; Neointima; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Pyrroles; Receptors, Platelet-Derived Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Sunitinib; Sus scrofa; Time Factors; Tissue Culture Techniques; Vascular Endothelial Growth Factor A | 2015 |
Behavioral Deficits in Juveniles Mediated by Maternal Stress Hormones in Mice.
Topics: Animals; Anxiety; Behavior, Animal; Depression; Depression, Postpartum; Disease Models, Animal; Female; Maternal Behavior; Mice; Mice, Knockout; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Receptors, GABA-A | 2016 |
Efficacy of targeted AKT inhibition in genetically engineered mouse models of PTEN-deficient prostate cancer.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Screening Assays, Antitumor; Genetic Engineering; Male; Mice; Mice, Knockout; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyrimidines; Pyrroles; Tumor Suppressor Protein p53 | 2016 |
Antitumoral Effect of Sunitinib-eluting Beads in the Rabbit VX2 Tumor Model.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Indoles; Liver Neoplasms, Experimental; Pyrroles; Rabbits; Sunitinib; Tumor Burden; Vascular Endothelial Growth Factor A | 2016 |
Detrimental Impact of Vasopressin V2 Receptor Antagonism in a SU5416/Hypoxia/Normoxia-Exposed Rat Model of Pulmonary Arterial Hypertension.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin; Up-Regulation; Ventricular Remodeling | 2016 |
Inhibition of development of laser-induced choroidal neovascularization with suppression of infiltration of macrophages in Smad3-null mice.
Topics: Animals; Choroidal Neovascularization; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Inflammation Mediators; Isoquinolines; Lasers, Gas; Macrophages; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Pyridines; Pyrroles; RNA, Messenger; Smad3 Protein; Transforming Growth Factor beta1 | 2016 |
Antinociceptive activity of intraperitoneally administered novel and potent anticonvulsive compound, CY-PROLL-SS, in animal neuropathic pain models.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Injections, Intraperitoneal; Male; Neuralgia; Pain Measurement; Pyrazines; Pyrroles; Rats; Streptozocin | 2016 |
The Na+/H+ exchanger contributes to increased smooth muscle proliferation and migration in a rat model of pulmonary arterial hypertension.
Topics: Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Hypertension, Pulmonary; Indoles; Male; Myocytes, Smooth Muscle; Pyrroles; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers | 2016 |
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Evoked Potentials; Imidazolidines; Indazoles; Iodoacetic Acid; Molecular Structure; NAV1.7 Voltage-Gated Sodium Channel; Osteoarthritis; Pain; Pain Measurement; Pyrroles; Rats; Sodium Channel Blockers; Structure-Activity Relationship | 2016 |
Discovery of novel pyrrole-based scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.
Topics: Administration, Oral; Animals; Biological Availability; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Discovery; Glucose Tolerance Test; Male; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Pyrroles; Receptors, G-Protein-Coupled; Structure-Activity Relationship | 2016 |
Multimodal Somatostatin Receptor Theranostics Using [(64)Cu]Cu-/[(177)Lu]Lu-DOTA-(Tyr(3))octreotate and AN-238 in a Mouse Pheochromocytoma Model.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Doxorubicin; Mice; Octreotide; Peptides, Cyclic; Pheochromocytoma; Pyrroles; Radiopharmaceuticals; Receptors, Somatostatin; Theranostic Nanomedicine; Treatment Outcome | 2016 |
Pneumonectomy combined with SU5416 induces severe pulmonary hypertension in rats.
Topics: Animals; Blood Pressure; Disease Models, Animal; Hypertension, Pulmonary; Indoles; Male; Pneumonectomy; Pyrroles; Rats, Sprague-Dawley | 2016 |
Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice.
Topics: Acetylcholinesterase; Animals; Antineoplastic Agents; Cholinergic Antagonists; Cholinesterase Inhibitors; Cognition Disorders; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Exploratory Behavior; Indans; Indoles; Male; Maze Learning; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Piperidines; Pyrroles; Scopolamine; Sunitinib | 2016 |
Use of a MCL-1 inhibitor alone to de-bulk melanoma and in combination to kill melanoma initiating cells.
Topics: Animals; Antineoplastic Agents; Bcl-2-Like Protein 11; Biphenyl Compounds; Cell Line, Tumor; Cell Self Renewal; Cell Survival; Disease Models, Animal; Drug Synergism; Female; Gene Knockout Techniques; Humans; Melanocytes; Melanoma; Mice; Mutation; Myeloid Cell Leukemia Sequence 1 Protein; Neoplastic Stem Cells; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Xenograft Model Antitumor Assays | 2017 |
Novel 1H-Pyrrolo[3,2-c]quinoline Based 5-HT6 Receptor Antagonists with Potential Application for the Treatment of Cognitive Disorders Associated with Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; CHO Cells; Cognition Disorders; Cricetulus; Cyclic AMP; Disease Models, Animal; HEK293 Cells; Humans; Male; Neuroblastoma; Phencyclidine; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Sulfones | 2016 |
Activation of the SDF1/CXCR4 pathway retards muscle atrophy during cancer cachexia.
Topics: Animals; Benzylamines; Biomarkers; Cachexia; Chemokine CXCL12; Cyclams; Cytokines; Disease Models, Animal; Female; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds; Humans; Indoles; Male; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Atrophy; Neoplasms; Pyrroles; Rats; Receptors, CXCR4; Signal Transduction; Sunitinib | 2016 |
JAK3-STAT pathway blocking benefits in experimental lupus nephritis.
Topics: Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Gene Expression Profiling; Janus Kinase 3; Lupus Nephritis; Mice; Mice, Inbred NZB; Piperidines; Polymerase Chain Reaction; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; STAT Transcription Factors; Transcriptome | 2016 |
The tyrosine kinase inhibitor, sunitinib malate, induces cognitive impairment in vivo via dysregulating VEGFR signaling, apoptotic and autophagic machineries.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Avoidance Learning; Body Temperature; Body Weight; Cognition Disorders; Disease Models, Animal; Female; Indoles; Locomotion; Maze Learning; Mice; Nerve Degeneration; Prepulse Inhibition; Pyrroles; RNA, Messenger; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor Receptor-2 | 2016 |
Sunitinib, a Small-Molecule Kinase Inhibitor, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice.
Topics: Animals; Bleomycin; Bronchi; Cell Proliferation; Disease Models, Animal; Epithelial Cells; Extracellular Matrix; Female; Fibroblasts; Humans; Indoles; Mesoderm; Mice; Mice, Inbred C57BL; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pulmonary Fibrosis; Pyrroles; Signal Transduction; Smad Proteins; Small Molecule Libraries; Sunitinib; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A | 2016 |
Distinct effects of inflammation on preconditioning and regeneration of the adult zebrafish heart.
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Cell Cycle; Cell Proliferation; Cryopreservation; Disease Models, Animal; Heart; Inflammation; Ischemic Preconditioning, Myocardial; Leukocytes; Myocardial Infarction; Myocytes, Cardiac; Pyrroles; Regeneration; Thoracotomy; Zebrafish | 2016 |
C-reactive protein promotes acute kidney injury via Smad3-dependent inhibition of CDK2/cyclin E.
Topics: Acute Kidney Injury; Animals; C-Reactive Protein; Cell Line, Tumor; Cell Proliferation; Creatinine; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Epithelial Cells; G1 Phase Cell Cycle Checkpoints; Humans; Isoquinolines; Kidney Tubules; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Phosphorylation; Pyridines; Pyrroles; Rats; Receptors, IgG; Regeneration; Smad3 Protein; Transforming Growth Factor beta | 2016 |
Everolimus affects vasculogenic mimicry in renal carcinoma resistant to sunitinib.
Topics: Angiogenesis Inhibitors; Animals; Axitinib; Carcinoma, Renal Cell; Disease Models, Animal; Disease Progression; Drug Resistance, Neoplasm; Everolimus; Female; Humans; Imidazoles; Indazoles; Indoles; Kidney Neoplasms; Mice; Mice, Nude; Neovascularization, Pathologic; Pyrroles; Random Allocation; Sunitinib; Xenograft Model Antitumor Assays | 2016 |
Successful chemoimmunotherapy against hepatocellular cancer in a novel murine model.
Topics: Adoptive Transfer; Animals; Carcinoma, Hepatocellular; CD8-Positive T-Lymphocytes; Cytotoxicity, Immunologic; Disease Models, Animal; Enzyme Inhibitors; Histocompatibility Antigens Class II; Immune Tolerance; Immunotherapy; Indoles; Liver Neoplasms; Mice; Neoplasm Staging; Programmed Cell Death 1 Receptor; Pyrroles; Sunitinib; T-Lymphocytes, Regulatory | 2017 |
ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzodiazepines; Cell Cycle; Cell Line, Tumor; Cell Survival; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hematologic Neoplasms; Histones; Humans; Immunoconjugates; Interleukin-2 Receptor alpha Subunit; Mice; Pyrroles; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Human heme oxygenase 1 is a potential host cell factor against dengue virus replication.
Topics: Animals; Biliverdine; Carbon Monoxide; Dengue; Dengue Virus; Disease Models, Animal; Diterpenes; Enzyme Inhibitors; Heme Oxygenase-1; Host-Pathogen Interactions; Humans; Interferon-alpha; Iron; Metalloporphyrins; Mice, Inbred ICR; Protoporphyrins; Pyrazines; Pyrroles; Serine Endopeptidases; Virus Replication | 2016 |
The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats.
Topics: Amnesia; Analysis of Variance; Animals; Avoidance Learning; Cholinesterase Inhibitors; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Histamine H3 Antagonists; Male; Pyrroles; Pyrrolidines; Quinazolines; Quinazolinones; Rats; Rats, Wistar; Scopolamine | 2016 |
NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility.
Topics: Ammonia; Animals; Animals, Newborn; Bumetanide; Cell Count; Cerebral Cortex; Disease Models, Animal; Epilepsy, Post-Traumatic; Evoked Potentials; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Phosphopyruvate Hydratase; Pyrazoles; Pyrroles; Seizures; Sodium Potassium Chloride Symporter Inhibitors; Solute Carrier Family 12, Member 2; Up-Regulation; Wakefulness | 2017 |
Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage.
Topics: Aminopyridines; Animals; Brain; Brain Edema; Cerebral Hemorrhage; Cytokines; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Microglia; Neuroimaging; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Species Specificity | 2017 |
Erythropoietin improves hypoxic-ischemic encephalopathy in neonatal rats after short-term anoxia by enhancing angiogenesis.
Topics: Angiogenesis Inducing Agents; Animals; Animals, Newborn; Cognition; Disease Models, Animal; Erythropoietin; Hippocampus; Hypoxia; Hypoxia-Ischemia, Brain; Indoles; Male; Pyrroles; Random Allocation; Rats, Sprague-Dawley; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; White Matter | 2016 |
HSP47 Promotes Glioblastoma Stemlike Cell Survival by Modulating Tumor Microenvironment Extracellular Matrix through TGF-β Pathway.
Topics: Analysis of Variance; Animals; Brain Neoplasms; Cell Survival; Computational Biology; Disease Models, Animal; Extracellular Matrix; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glioblastoma; HSP47 Heat-Shock Proteins; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplastic Stem Cells; Platelet Endothelial Cell Adhesion Molecule-1; Pyrazoles; Pyrroles; RNA, Messenger; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2017 |
Tofacitinib induces G1 cell-cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells.
Topics: Animals; Apoptosis; Biomarkers; Cell Line, Tumor; Disease Models, Animal; Epstein-Barr Virus Infections; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Viral; Herpesvirus 4, Human; Humans; Janus Kinase 3; Killer Cells, Natural; Lymphocyte Activation; Lymphoma, T-Cell; Mice; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; STAT5 Transcription Factor; T-Lymphocytes; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
High Potency VEGFRs/MET/FMS Triple Blockade by TAS-115 Concomitantly Suppresses Tumor Progression and Bone Destruction in Tumor-Induced Bone Disease Model with Lung Carcinoma Cells.
Topics: A549 Cells; Animals; Bone Neoplasms; Cell Differentiation; Cell Proliferation; Crizotinib; Disease Models, Animal; Humans; Indoles; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Osteoclasts; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyrazoles; Pyridines; Pyrroles; Quinolines; RANK Ligand; Receptor, Macrophage Colony-Stimulating Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Sunitinib; Thiourea; Tibia; Transplantation, Heterologous; X-Ray Microtomography | 2016 |
Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition.
Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Drug Discovery; Encephalomyelitis, Autoimmune, Experimental; Humans; Interleukin-10; Interleukin-1beta; Janus Kinase 1; Janus Kinase 3; Macrophages; Mice; Models, Molecular; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Th1 Cells; Th17 Cells; Tumor Necrosis Factor-alpha | 2016 |
Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration.
Topics: Adult; Aged; Animals; Annulus Fibrosus; Disease Models, Animal; Female; Humans; Interleukin-6; Intervertebral Disc Degeneration; Janus Kinases; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein | 2017 |
SCH 79797, a selective PAR1 antagonist, protects against ischemia/reperfusion-induced arrhythmias in the rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Male; Myocardial Reperfusion Injury; Pyrroles; Quinazolines; Rats; Rats, Wistar; Receptor, PAR-1 | 2016 |
Intestinal adaptation in proximal and distal segments: Two epithelial responses diverge after intestinal separation.
Topics: Adaptation, Physiological; Animals; beta Catenin; Biomarkers; Biopsy, Needle; Cell Proliferation; Disease Models, Animal; Immunohistochemistry; Intestinal Mucosa; Intestine, Small; Male; Pyrimidines; Pyrroles; Random Allocation; Real-Time Polymerase Chain Reaction; Reference Values; Sensitivity and Specificity; Short Bowel Syndrome; Zebrafish | 2017 |
The role of spinal thrombin through protease-activated receptor 1 in hyperalgesia after neural injury.
Topics: Animals; Antithrombins; Capillary Permeability; Central Nervous System Agents; Cervical Vertebrae; Disease Models, Animal; Fibrin; Hirudins; Hyperalgesia; Injections, Spinal; Male; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pyrroles; Quinazolines; Radiculopathy; Rats, Sprague-Dawley; Receptor, PAR-1; Spinal Cord | 2017 |
Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17/Treg Balance.
Topics: Animals; CD4 Lymphocyte Count; Cells, Cultured; Dendritic Cells; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Immune Tolerance; Immunotherapy, Adoptive; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells | 2016 |
Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin αvβ3/FAK/AKT Pathway Suppression.
Topics: Animals; Arterial Pressure; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Focal Adhesion Kinase 1; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Integrin alphaVbeta3; Male; Mice, Knockout; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Osteoprotegerin; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; RNA Interference; Severity of Illness Index; Signal Transduction; Transfection; Vascular Remodeling; Walk Test | 2017 |
Tofacitinib ameliorates inflammation in a rat model of airway neutrophilia induced by inhaled LPS.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Inflammation; Janus Kinases; Lipopolysaccharides; Lung; Male; Neutrophils; Phosphorylation; Piperidines; Pneumonia; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor | 2017 |
The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration.
Topics: Acyltransferases; Animals; Antineoplastic Agents; Autophagy; Cognitive Dysfunction; Cyclin-Dependent Kinase 5; Disease Models, Animal; Disease Progression; Gene Expression Regulation; HIV Infections; HIV-1; Humans; Indoles; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Neurons; Pyrroles; Sequestosome-1 Protein; Signal Transduction; Sunitinib; tat Gene Products, Human Immunodeficiency Virus; Transgenes | 2017 |
The Role of Vascular Endothelial Growth Factor in Small-airway Remodelling in a Rat Model of Chronic Obstructive Pulmonary Disease.
Topics: Airway Remodeling; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Indoles; Lipopolysaccharides; Male; Neovascularization, Pathologic; Nicotiana; Pulmonary Disease, Chronic Obstructive; Pyrroles; Rats, Sprague-Dawley; Smoke; Sunitinib; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2017 |
Dabigatran ameliorates post-haemorrhagic hydrocephalus development after germinal matrix haemorrhage in neonatal rat pups.
Topics: Administration, Intranasal; Animals; Animals, Newborn; Antithrombins; Dabigatran; Disease Models, Animal; Extracellular Matrix; Hydrocephalus; Injections, Intraperitoneal; Intracranial Hemorrhages; Maze Learning; Oligopeptides; Pyrroles; Quinazolines; Receptor, PAR-1; Rotarod Performance Test | 2017 |
In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis.
Topics: Animals; Brain; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Genetic Therapy; Mice, Inbred C57BL; Multiple Sclerosis; Pentosyltransferases; Pyrimidinones; Pyrroles; RNA, Transfer; Thioguanine | 2017 |
Blockage of transient receptor potential vanilloid 4 alleviates myocardial ischemia/reperfusion injury in mice.
Topics: Animals; Apoptosis; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression; Gene Knockout Techniques; Glycogen Synthase Kinase 3 beta; Heart Function Tests; Mice; Molecular Targeted Therapy; Morpholines; Myocardial Reperfusion Injury; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrroles; Signal Transduction; TRPV Cation Channels | 2017 |
Upregulation of long non-coding RNA PlncRNA-1 promotes proliferation and induces epithelial-mesenchymal transition in prostate cancer.
Topics: Animals; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Silencing; Humans; Male; Mice; Prostatic Neoplasms; Pyrazoles; Pyrroles; RNA, Long Noncoding; Signal Transduction; Transforming Growth Factor beta1; Xenograft Model Antitumor Assays | 2017 |
Multifunctional biocompatible chitosan-polypyrrole nanocomposites as novel agents for photoacoustic imaging-guided photothermal ablation of cancer.
Topics: Animals; Cell Line, Tumor; Chitosan; Disease Models, Animal; Female; Humans; Hyperthermia, Induced; Mice; Nanocomposites; Neoplasms; Photoacoustic Techniques; Phototherapy; Polymers; Pyrroles; Xenograft Model Antitumor Assays | 2017 |
Depletion of microglia exacerbates postischemic inflammation and brain injury.
Topics: Aminopyridines; Animals; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Inflammation Mediators; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Microglia; Neurons; Primary Cell Culture; Proto-Oncogene Proteins c-kit; Pyrroles; Reactive Oxygen Species; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor | 2017 |
Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: preventive and therapeutic effects on experimental autoimmune encephalomyelitis.
Topics: Adoptive Transfer; Animals; Benzazepines; Cell Differentiation; Cell Polarity; Dendritic Cells; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Interleukin-17; Lymphocyte Activation; Mice; Pyridines; Pyrroles; Receptors, Dopamine D1; T-Lymphocytes, Helper-Inducer | 2008 |
Characterization of angiotensin II antagonism displayed by Ib, a novel nonpeptide angiotensin AT(1) receptor antagonist.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Cattle; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Injections, Intravenous; Liver; Losartan; Male; Protein Binding; Pyrroles; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Time Factors; Triazoles; Vasoconstriction | 2008 |
Failure of oral atorvastatin to modulate a murine model of systemic lupus erythematosus.
Topics: Administration, Oral; Animals; Antibodies, Antinuclear; Atorvastatin; Cell Proliferation; Cholesterol; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-4; Lupus Erythematosus, Systemic; Mice; Mice, Inbred NZB; Pyrroles; T-Lymphocytes; Treatment Outcome | 2008 |
Effects of atorvastatin on progression-regression of renal injury in hyperlipidemic chickens.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Chickens; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Heptanoic Acids; Hyperlipidemias; Kidney Diseases; Kidney Glomerulus; Kidney Tubules; Lipids; Male; Pyrroles | 2008 |
Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell death.
Topics: Animals; Atorvastatin; Cell Death; Disease Models, Animal; Dose-Response Relationship, Drug; Ectodysplasins; Heptanoic Acids; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; Inflammation; Interleukin-1beta; Kainic Acid; Male; Nitric Oxide Synthase Type II; Pyrroles; Rats; Rats, Sprague-Dawley; Seizures; Tumor Necrosis Factor-alpha | 2008 |
Haloperidol both prevents and reverses quinpirole-induced nonregulatory water intake, a putative animal model of psychogenic polydipsia.
Topics: Administration, Oral; Animals; Antipsychotic Agents; Benzodiazepines; Clomipramine; Clozapine; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Haloperidol; Male; Olanzapine; Piperazines; Pyrroles; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Thiazepines | 2008 |
PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior.
Topics: Amygdala; Animals; Arthritis; Behavior; Butadienes; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Indoles; Male; Maleimides; Neuronal Plasticity; Neurons; Nitriles; Pain; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Thionucleotides | 2008 |
Hypoxia-induced retinal angiogenesis in zebrafish as a model to study retinopathy.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Green Fluorescent Proteins; Humans; Hypoxia; Indoles; Microscopy, Confocal; Neovascularization, Pathologic; Pyrroles; Receptors, Notch; Retinal Diseases; Retinal Neovascularization; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor A; Zebrafish | 2008 |
The effect of polypyrrole on arteriogenesis in an acute rat infarct model.
Topics: Alginates; Animals; Arteries; Cell Adhesion; Cell Proliferation; Cell Shape; Cell Survival; Disease Models, Animal; Electric Conductivity; Endothelial Cells; Female; Glucuronic Acid; Hexuronic Acids; Humans; Myocardial Infarction; Organogenesis; Polymers; Pyrroles; Rats; Rats, Sprague-Dawley; Tissue Scaffolds | 2008 |
Atorvastatin enhances hypothermia-induced neuroprotection after stroke.
Topics: Animals; Atorvastatin; Brain Infarction; CD11b Antigen; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypothermia, Induced; Magnetic Resonance Imaging; Male; Neurologic Examination; Nitric Oxide Synthase Type II; Pyrroles; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Stroke | 2008 |
Statins alone are ineffective in cerebral malaria but potentiate artesunate.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Atorvastatin; Disease Models, Animal; Drug Synergism; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Malaria, Cerebral; Malaria, Falciparum; Mice; Neuroprotective Agents; Pravastatin; Pyrroles; Simvastatin | 2008 |
Atorvastatin efficiency after traumatic brain injury in rats.
Topics: Analysis of Variance; Animals; Atorvastatin; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Craniotomy; Disease Models, Animal; Heptanoic Acids; Lipid Peroxidation; Male; Microcirculation; Microscopy, Electron, Transmission; Neuroprotective Agents; Organ Size; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley | 2009 |
Atorvastatin inhibits renal crystal retention in a rat stone forming model.
Topics: Animals; Apoptosis; Atorvastatin; Biopsy, Needle; Disease Models, Animal; Heptanoic Acids; Immunohistochemistry; Kidney Calculi; Kidney Tubules; Male; Oxalates; Oxidative Stress; Probability; Pyrroles; Random Allocation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Statistics, Nonparametric; Superoxide Dismutase; Urinalysis | 2008 |
Identification of 4-[1-[3-chloro-4-[N'-(5-fluoro-2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]benzoic acid as a potent, orally active VLA-4 antagonist.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Asthma; Benzoates; Cells, Cultured; Disease Models, Animal; Dogs; Female; Inhibitory Concentration 50; Integrin alpha4beta1; Mice; Mice, Inbred BALB C; Permeability; Pyrroles; Rats | 2008 |
Arrhythmogenic actions of the Ca2+ channel agonist FPL-64716 in Langendorff-perfused murine hearts.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Disease Models, Animal; Electric Stimulation; Heart; Homeostasis; Indoles; Mice; Mice, Inbred Strains; Myocytes, Cardiac; Nifedipine; Pyrroles; Sarcoplasmic Reticulum; Tachycardia, Ventricular | 2009 |
Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Atorvastatin; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Hepatic Stellate Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Infusion Pumps, Implantable; Intercellular Adhesion Molecule-1; Interleukin-6; Liver; Male; Oxidative Stress; Pyrroles; Rats; Rats, Wistar; Transforming Growth Factor beta1 | 2009 |
Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice.
Topics: Analysis of Variance; Anesthetics; Animals; Arginine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Histidine; Hyperalgesia; Indoles; Male; Mice; Mice, Mutant Strains; Motor Activity; Physical Stimulation; Point Mutation; Protein Subunits; Pyrroles; Receptors, GABA-A | 2009 |
A pyrrole-imidazole polyamide targeting transforming growth factor-beta1 inhibits restenosis and preserves endothelialization in the injured artery.
Topics: Animals; Carotid Artery Injuries; Carotid Stenosis; Cell Proliferation; Cells, Cultured; Collagen Type I; Connective Tissue Growth Factor; Disease Models, Animal; Endothelium, Vascular; Fibronectins; Gene Silencing; Hyperplasia; Imidazoles; Male; Muscle, Smooth, Vascular; Nylons; Promoter Regions, Genetic; Pyrroles; Rats; Rats, Inbred WKY; RNA, Messenger; Scavenger Receptors, Class E; Secondary Prevention; Transforming Growth Factor beta1 | 2009 |
Dopamine D3 receptor stimulation underlies the development of L-DOPA-induced dyskinesia in animal models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Benzopyrans; Callithrix; Corpus Striatum; Disease Models, Animal; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Antagonists; Dyskinesia, Drug-Induced; Enkephalins; Female; Levodopa; Male; Oxidopamine; Parkinsonian Disorders; Protein Precursors; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger | 2009 |
Atorvastatin ameliorates sildenafil-induced penile erections in experimental diabetes by inhibiting diabetes-induced RhoA/Rho-kinase signaling hyperactivation.
Topics: Animals; Atorvastatin; Diabetes Mellitus, Experimental; Disease Models, Animal; Electric Stimulation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Penile Erection; Phosphodiesterase Inhibitors; Phosphorylation; Piperazines; Purines; Pyrroles; Rabbits; rho-Associated Kinases; Signal Transduction; Sildenafil Citrate; Sulfones | 2009 |
Lack of efficacy of the statins atorvastatin and lovastatin in rodent mammary carcinogenesis.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Anticholesteremic Agents; Antineoplastic Agents, Hormonal; Apoptosis; Atorvastatin; Bexarotene; Cell Proliferation; Diet; Disease Models, Animal; Female; Genes, erbB-2; Heptanoic Acids; Lovastatin; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Knockout; Mice, Transgenic; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Retinoid X Receptors; Tamoxifen; Tetrahydronaphthalenes; Treatment Outcome; Tumor Suppressor Protein p53 | 2009 |
3-Hydroxy-3-methylglutaryl (HMG)-COA reductase inhibitors and phosphodiesterase type V inhibitors attenuate right ventricular pressure and remodeling in a rat model of pulmonary hypertension.
Topics: Animals; Atorvastatin; Disease Models, Animal; Hemodynamics; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; Phosphodiesterase Inhibitors; Pravastatin; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Simvastatin | 2009 |
Atorvastatin restores endothelial function in offspring of protein-restricted rats in a cholesterol-independent manner.
Topics: Animals; Atorvastatin; Cholesterol; Disease Models, Animal; Endothelium, Vascular; Female; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Male; Nitric Oxide Synthase Type III; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Protein-Energy Malnutrition; Pyrroles; Rats; Rats, Wistar; RNA, Messenger; Vasculitis; Vasoconstriction; Weight Gain | 2009 |
Statins reduce the neurofibrillary tangle burden in a mouse model of tauopathy.
Topics: Animals; Atorvastatin; Azetidines; Brain; Capillary Permeability; Diet; Disease Models, Animal; Ezetimibe; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Immunohistochemistry; Maze Learning; Mice; Mice, Transgenic; Neurofibrillary Tangles; Pyrroles; Simvastatin; Spinal Cord; Tauopathies | 2009 |
Anti-atherogenic effect of statins: role of nitric oxide, peroxynitrite and haem oxygenase-1.
Topics: Animals; Aorta; Arginine; Atherosclerosis; Atorvastatin; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Heme Oxygenase-1; Hemin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Peroxidation; Male; Malondialdehyde; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Protoporphyrins; Pyrroles; Rabbits; Simvastatin; Time Factors | 2009 |
Antitumor and apoptosis promoting properties of atorvastatin, an inhibitor of HMG-CoA reductase, against Dalton's Lymphoma Ascites tumor in mice.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Atorvastatin; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Peroxidation; Male; Mice; Models, Chemical; Neoplasms, Experimental; Pyrroles; Reactive Oxygen Species | 2008 |
Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Immunohistochemistry; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Pyridazines; Pyrroles; Receptors, Nicotinic; Signal Transduction; tau Proteins | 2009 |
VEGF and angiogenesis in acute and chronic MOG((35-55)) peptide induced EAE.
Topics: Angiogenesis Inhibitors; Angiogenic Proteins; Animals; Blood Vessels; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Glycoproteins; Indoles; Laminin; Mice; Mice, Inbred C57BL; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Neovascularization, Pathologic; Peptide Fragments; Pyrroles; RNA, Messenger; Spinal Cord; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Wallerian Degeneration | 2009 |
Evaluation of a novel calpain inhibitor as a treatment for cataract.
Topics: Animals; Calpain; Cataract; Cell Survival; Cells, Cultured; Cysteine Endopeptidases; Dipeptides; Disease Models, Animal; Glycoproteins; Humans; Models, Molecular; Ointments; Ophthalmic Solutions; Pyrroles; Sheep; Sheep Diseases | 2008 |
Up-regulating PPAR-γ expression and NO concentration, and down-regulating PAI-1 concentration in a rabbit atherosclerotic model: the possible antiatherogenic and antithrombotic effects of atorvastatin.
Topics: Animals; Atherosclerosis; Atorvastatin; Disease Models, Animal; Down-Regulation; Fibrinolytic Agents; Heptanoic Acids; Male; Nitric Oxide; Plasminogen Activator Inhibitor 1; PPAR gamma; Pyrroles; Rabbits; Up-Regulation | 2010 |
Sunitinib prolongs survival in genetically engineered mouse models of multistep lung carcinogenesis.
Topics: AMP-Activated Protein Kinases; Angiogenesis Inhibitors; Animals; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Disease Models, Animal; Genetic Engineering; Immunohistochemistry; Indoles; Lung Neoplasms; Mice; Mutation; Neoplasm Metastasis; Neovascularization, Pathologic; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins p21(ras); Pyrroles; Sunitinib | 2009 |
Antiangiogenic synergism of integrin-targeted fumagillin nanoparticles and atorvastatin in atherosclerosis.
Topics: Angiogenesis Inhibitors; Animals; Aorta, Thoracic; Atherosclerosis; Atorvastatin; Carbocyanines; Cyclohexanes; Disease Models, Animal; Drug Carriers; Drug Synergism; Drug Therapy, Combination; Fatty Acids, Unsaturated; Heptanoic Acids; Heterocyclic Compounds, 1-Ring; Integrin alphaVbeta3; Liver; Magnetic Resonance Imaging; Nanoparticles; Neovascularization, Pathologic; Pyrroles; Rabbits; Sesquiterpenes; Time Factors | 2008 |
Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models.
Topics: Animals; Atorvastatin; Benzenesulfonates; Cystadenoma; Disease Models, Animal; Doxycycline; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Heptanoic Acids; Immunosuppressive Agents; Interferon-gamma; Kidney Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Neoplasms, Experimental; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pyridines; Pyrroles; Sirolimus; Sorafenib; Survival Analysis; Treatment Outcome; Tuberous Sclerosis; Tuberous Sclerosis Complex 2 Protein; Tumor Burden; Tumor Suppressor Proteins | 2009 |
Atorvastatin prevents endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats: role of cyclooxygenase 2-derived contracting prostanoids.
Topics: Analysis of Variance; Animals; Atorvastatin; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Endothelium, Vascular; Heptanoic Acids; Male; Malondialdehyde; Mesenteric Arteries; Probability; Prostaglandins; Pyrroles; Random Allocation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sensitivity and Specificity; Vasodilation | 2009 |
Effect of atorvastatin on cardiac remodelling and mortality in rats following hyperglycemia and myocardial infarction.
Topics: Animals; Atorvastatin; Body Weight; Cardiac Volume; Collagen Type I; Collagen Type III; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Myocardial Infarction; Myocardium; Pyrroles; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2010 |
Antihyperlipidemic effect of the methanolic extract from Lagenaria siceraria Stand. fruit in hyperlipidemic rats.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Bile Acids and Salts; Cholesterol; Cucurbitaceae; Dietary Fats; Disease Models, Animal; Feces; Fruit; Heptanoic Acids; Hyperlipidemias; Hypolipidemic Agents; Male; Phytotherapy; Plant Extracts; Pyrroles; Rats; Rats, Wistar; Triglycerides; Weight Gain | 2009 |
Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors.
Topics: Animals; Atherosclerosis; Atorvastatin; Capillary Permeability; Cattle; Cells, Cultured; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Farnesol; Female; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins, LDL; Protein Kinase C; Protein Kinase Inhibitors; Protein-Lysine 6-Oxidase; Pyrroles; rho-Associated Kinases; rhoA GTP-Binding Protein; Risk Factors; RNA, Messenger; Simvastatin; Swine; Transfection; Tumor Necrosis Factor-alpha | 2009 |
In vivo antitumor and antimetastatic activity of sunitinib in preclinical neuroblastoma mouse model.
Topics: Angiogenesis Inhibitors; Animals; Blotting, Western; Cell Line, Tumor; Disease Models, Animal; Gene Expression; Humans; Immunohistochemistry; Indoles; Mice; Neovascularization, Pathologic; Neuroblastoma; Oligonucleotide Array Sequence Analysis; Pyrroles; Sunitinib; Xenograft Model Antitumor Assays | 2009 |
Vascular endothelial growth factor receptor inhibitor enhances dietary salt-induced hypertension in Sprague-Dawley rats.
Topics: Albuminuria; Angiogenesis Inhibitors; Animals; Blood Pressure; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Epithelial Cells; Heart Rate; Humans; Hypertension; Indoles; Injections, Intraperitoneal; Kidney; Kidney Glomerulus; Kidney Tubules, Proximal; Male; Natriuresis; Nitric Oxide; Nitric Oxide Synthase Type III; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; Sodium Chloride, Dietary; Vascular Endothelial Growth Factor A | 2009 |
Sunitinib and PF-562,271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Disease Models, Animal; Dose-Response Relationship, Drug; Focal Adhesion Kinase 2; Humans; Indoles; Liver Neoplasms; Male; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Nude; Sulfonamides; Sunitinib; Xenograft Model Antitumor Assays | 2009 |
VEGF inhibition and metastasis: possible implications for antiangiogenic therapy.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzenesulfonates; Bevacizumab; Disease Models, Animal; Humans; Indoles; Neoplasm Metastasis; Neoplasms; Niacinamide; Phenylurea Compounds; Pyridines; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Sorafenib; Sunitinib; Treatment Outcome; Vascular Endothelial Growth Factor A | 2009 |
Atorvastatin prevents hippocampal cell death due to quinolinic acid-induced seizures in mice by increasing Akt phosphorylation and glutamate uptake.
Topics: Analysis of Variance; Animals; Atorvastatin; Cell Death; Complex Mixtures; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Heptanoic Acids; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Male; Mice; Oncogene Protein v-akt; Phosphorylation; Pyrroles; Quinolinic Acid; Seizures; Tetrazolium Salts; Thiazoles; Tritium | 2009 |
Combination of sunitinib, cetuximab and irradiation in an orthotopic head and neck cancer model.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cetuximab; Combined Modality Therapy; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Head and Neck Neoplasms; Humans; Indoles; Mice; Mice, Nude; Neoplasm Transplantation; Pyrroles; Radiotherapy; Sunitinib; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2009 |
Swim stress excitation of nucleus incertus and rapid induction of relaxin-3 expression via CRF1 activation.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Gene Expression Regulation; Male; Nerve Tissue Proteins; Neurons; Paraventricular Hypothalamic Nucleus; Pons; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Relaxin; RNA, Messenger; Stress, Psychological; Swimming; Time Factors | 2010 |
Pivotal role of inflammation in vascular endothelial dysfunction of hyperlipidemic rabbit and effects by atorvastatin.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Biomarkers; Blood Glucose; Dietary Fats; Disease Models, Animal; Endothelium, Vascular; Heptanoic Acids; Hyperlipidemias; Insulin; Lipids; Male; Pyrroles; Rabbits; Vasculitis | 2011 |
Reduction in endothelial tip cell filopodia corresponds to reduced intravitreous but not intraretinal vascularization in a model of ROP.
Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Caspase 3; Cell Movement; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Indoles; Infant, Newborn; Integrin beta3; Neovascularization, Pathologic; Phosphorylation; Protein Kinase Inhibitors; Pseudopodia; Pyrroles; Rats; Rats, Sprague-Dawley; Retinal Vessels; Retinopathy of Prematurity; Time Factors; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Vitreous Body | 2009 |
Renal and liver tumors in Tsc2(+/-) mice, a model of tuberous sclerosis complex, do not respond to treatment with atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.
Topics: Animals; Atorvastatin; Cholesterol; Cystadenoma; Disease Models, Animal; Female; Hemangioma; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoenzyme Techniques; Kidney Neoplasms; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyrroles; Survival Rate; Tuberous Sclerosis; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2009 |
Liver cyst cytokines promote endothelial cell proliferation and development.
Topics: Animals; Cell Proliferation; Cells, Cultured; Cyst Fluid; Cysts; Cytokines; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Humans; Indoles; Liver Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Polycystic Kidney, Autosomal Dominant; Pyrroles; TRPP Cation Channels; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2009 |
Protein kinase C beta inhibitor prevents diabetic peripheral neuropathy, but not histopathological abnormalities of retina in Spontaneously Diabetic Torii rat.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Indans; Male; Neural Conduction; Protein Kinase C; Protein Kinase C beta; Pyrroles; Rats | 2009 |
Development and maturation of invariant NKT cells in the presence of lysosomal engulfment.
Topics: Animals; Cell Count; Cell Differentiation; Disease Models, Animal; Enzyme Inhibitors; Female; Leukodystrophy, Globoid Cell; Leukodystrophy, Metachromatic; Liver; Lymphocytes; Lysosomal Storage Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Mucopolysaccharidosis I; Multiple Sulfatase Deficiency Disease; Natural Killer T-Cells; Pyrroles; Receptor, Fibroblast Growth Factor, Type 1; Sandhoff Disease; Spleen; Thymus Gland | 2009 |
Atorvastatin extends the therapeutic window for tPA to 6 h after the onset of embolic stroke in rats.
Topics: Animals; Atorvastatin; Cerebrovascular Circulation; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Fibrinolytic Agents; Heptanoic Acids; Immunohistochemistry; Intracranial Embolism; Male; Neuroprotective Agents; Pyrroles; Rats; Rats, Wistar; Stroke; Time Factors; Tissue Plasminogen Activator | 2009 |
Simvastatin and atorvastatin improve neurological outcome after experimental intracerebral hemorrhage.
Topics: Animals; Apoptosis; Atorvastatin; Biomarkers; Brain; Brain Infarction; Bromodeoxyuridine; Cerebral Hemorrhage; Cytoprotection; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Microtubule-Associated Proteins; Nerve Degeneration; Neurogenesis; Neuronal Plasticity; Neuropeptides; Neuroprotective Agents; Pyrroles; Rats; Rats, Wistar; Regeneration; Simvastatin; Treatment Outcome | 2009 |
Atorvastatin reverses cardiac remodeling possibly through regulation of protein kinase D/myocyte enhancer factor 2D activation in spontaneously hypertensive rats.
Topics: Animals; Atorvastatin; Blood Pressure; Disease Models, Animal; Enzyme Activation; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxyproline; Hypertension; Hypertrophy, Left Ventricular; Lipids; Male; MEF2 Transcription Factors; Myocardium; Protein Kinase C; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction; Time Factors; Transcription Factors; Ventricular Remodeling | 2010 |
Atorvastatin attenuates NF-kappaB activation in trigeminal nucleus caudalis in a rat model of migraine.
Topics: Analysis of Variance; Animals; Atorvastatin; Blotting, Western; Cell Nucleus; Disease Models, Animal; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Migraine Disorders; Neoplasm Proteins; Neurons; NF-kappa B; Nitroglycerin; Nucleocytoplasmic Transport Proteins; Pyrroles; Rats; Rats, Sprague-Dawley; Trigeminal Caudal Nucleus | 2009 |
Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis.
Topics: Acetylcholine; Animals; Aorta; Atorvastatin; Biological Factors; Blood Cell Count; Blood Pressure; Calcium Channel Blockers; Cytochrome P-450 Enzyme Inhibitors; Disease Models, Animal; Endothelium, Vascular; Gene Expression; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypotension; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Nitroprusside; Phenylephrine; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Sepsis; Vasodilation | 2009 |
FDG-PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis.
Topics: Animals; Aorta; Atherosclerosis; Atorvastatin; Catheterization; Cholesterol, Dietary; Diagnosis, Differential; Disease Models, Animal; Fluorodeoxyglucose F18; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Macrophages; Male; Positron-Emission Tomography; Predictive Value of Tests; Pyrroles; Rabbits; Radiopharmaceuticals | 2010 |
Synthesis and structural characterization of carboxyethylpyrrole-modified proteins: mediators of age-related macular degeneration.
Topics: Amino Acid Sequence; Animals; Antibodies; Biotinylation; Disease Models, Animal; Macular Degeneration; Mice; Peptides; Protein Denaturation; Pyrroles; Retina; Serum Albumin; Trypsin | 2009 |
The functional changes of the perivascular adipose tissue in spontaneously hypertensive rats and the effects of atorvastatin therapy.
Topics: Adipose Tissue; Animals; Aorta, Thoracic; Atorvastatin; Connective Tissue; Disease Models, Animal; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasoconstriction; Vasodilation | 2009 |
Atorvastatin inhibits inflammatory angiogenesis in mice through down regulation of VEGF, TNF-alpha and TGF-beta1.
Topics: Administration, Oral; Animals; Atorvastatin; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Macrophages; Male; Mice; Neovascularization, Pathologic; Pyrroles; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2010 |
18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Atorvastatin; Binding, Competitive; Cells, Cultured; Contrast Media; Disease Models, Animal; Endothelium, Vascular; Feasibility Studies; Fluorodeoxyglucose F18; Graft Rejection; Half-Life; Heart Transplantation; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Inflammation Mediators; Iopamidol; Ligands; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Peptides; Positron-Emission Tomography; Predictive Value of Tests; Pyrroles; Radiopharmaceuticals; Reproducibility of Results; RNA, Messenger; Tissue Distribution; Tomography, X-Ray Computed; Vascular Cell Adhesion Molecule-1 | 2009 |
Atorvastatin prevents gentamicin-induced renal damage in rats through the inhibition of p38-MAPK and NF-kappaB pathways.
Topics: Analysis of Variance; Animals; Atorvastatin; Chi-Square Distribution; Disease Models, Animal; Free Radical Scavengers; Gentamicins; Heptanoic Acids; Immunohistochemistry; Kidney Function Tests; Kidney Tubular Necrosis, Acute; Male; MAP Kinase Signaling System; NF-kappa B; Nitric Oxide; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Probability; Pyrroles; Random Allocation; Rats; Rats, Wistar | 2009 |
D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD.
Topics: Amphetamine; Animals; Attention Deficit Disorder with Hyperactivity; Benzopyrans; Corpus Striatum; Dihydroxyphenylalanine; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Extracellular Space; Indoles; Locomotion; Mice; Mice, Knockout; Mice, Mutant Strains; Piperidines; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4 | 2010 |
Reduced intimal hyperplasia in rabbits via medical therapy after carotid venous bypass.
Topics: Administration, Oral; Animals; Atorvastatin; Benzopyrans; Calcium Dobesilate; Cardiovascular Agents; Carotid Stenosis; Clopidogrel; Disease Models, Animal; Ethanolamines; Graft Occlusion, Vascular; Heptanoic Acids; Hyperplasia; Jugular Veins; Male; Nebivolol; Pyrroles; Rabbits; Ticlopidine; Tunica Intima; Vascular Surgical Procedures | 2009 |
Lack of robust neurologic benefits with simvastatin or atorvastatin treatment after acute thoracic spinal cord contusion injury.
Topics: Analysis of Variance; Animals; Atorvastatin; Benzenesulfonates; Dietary Sucrose; Disease Models, Animal; Drug Administration Routes; Ectodysplasins; Exploratory Behavior; Food, Formulated; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Motor Activity; Nervous System Diseases; Pain Measurement; Pain Threshold; Psychomotor Performance; Pyrroles; Rats; Rats, Sprague-Dawley; Sacrococcygeal Region; Simvastatin; Spinal Cord Injuries | 2010 |
Effect of atorvastatin and diet on non-alcoholic fatty liver disease activity score in hyperlipidemic chickens.
Topics: Animals; Atorvastatin; Chickens; Cholesterol; Disease Models, Animal; Fatty Liver; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Inflammation; Male; Pyrroles; Severity of Illness Index; Triglycerides | 2010 |
Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Humans; In Vitro Techniques; Lactones; Lenalidomide; Mice; Mice, SCID; Multiple Myeloma; Proteasome Inhibitors; Pyrroles; Thalidomide; Xenograft Model Antitumor Assays | 2010 |
Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema.
Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Ceramides; Disease Models, Animal; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Indoles; Lysophospholipids; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Propylene Glycols; Pulmonary Alveoli; Pulmonary Emphysema; Pyrroles; Receptors, Lysosphingolipid; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Sphingosine | 2010 |
The alarm pheromone in male rats as a unique anxiety model: psychopharmacological evidence using anxiolytics.
Topics: Administration, Inhalation; Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Clonidine; Disease Models, Animal; Male; Midazolam; Phenelzine; Pheromones; Propranolol; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Reflex, Startle | 2010 |
TSU68, an antiangiogenic receptor tyrosine kinase inhibitor, induces tumor vascular normalization in a human cancer xenograft nude mouse model.
Topics: Angiogenesis Inhibitors; Animals; Colon; Colonic Neoplasms; Disease Models, Animal; Drug Delivery Systems; Humans; Indoles; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Neovascularization, Physiologic; Oxindoles; Propionates; Pyrroles; Receptors, Fibroblast Growth Factor; Receptors, Platelet-Derived Growth Factor; Sensitivity and Specificity; Transplantation, Heterologous; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays | 2009 |
Atorvastatin improves the impaired baroreflex sensitivity via anti-oxidant effect in the rostral ventrolateral medulla of SHRSP.
Topics: Animals; Atorvastatin; Baroreflex; Blood Pressure; Disease Models, Animal; Heart Rate; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Medulla Oblongata; Oxidative Stress; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2009 |
Vascular endothelial growth factor is involved in mediating increased de novo hippocampal neurogenesis in response to traumatic brain injury.
Topics: Animals; Biomarkers; Brain Injuries; Bromodeoxyuridine; Cell Death; Cell Proliferation; Disease Models, Animal; Doublecortin Domain Proteins; Hippocampus; In Situ Nick-End Labeling; Indoles; Infusion Pumps, Implantable; Male; Microtubule-Associated Proteins; Nerve Regeneration; Neurogenesis; Neuropeptides; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Recovery of Function; Stem Cells; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2010 |
Atorvastatin improves insulin sensitivity in mice with obesity induced by monosodium glutamate.
Topics: Adipose Tissue; Administration, Oral; Animals; Atorvastatin; Blood Glucose; Blotting, Western; Disease Models, Animal; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Insulin Resistance; Lipid Metabolism; Mice; Mice, Inbred ICR; Obesity; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sodium Glutamate | 2010 |
CREB activation mediates VEGF-A's protection of neurons and cerebral vascular endothelial cells.
Topics: Animals; Animals, Newborn; Brain Injuries; Cell Survival; Cells, Cultured; Chromones; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Glial Fibrillary Acidic Protein; Glucose; Hypoxia; Hypoxia-Ischemia, Brain; Indoles; Injections, Intraventricular; Male; Morpholines; Neurons; Phosphorylation; Placenta Growth Factor; Platelet Endothelial Cell Adhesion Molecule-1; Pregnancy Proteins; Pyrroles; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction; Time Factors; Transfection; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2010 |
Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke.
Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Apoptosis; Calpain; Caspase 3; Cell Proliferation; Cerebral Arteries; Disease Models, Animal; Endothelial Cells; Indoles; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Necrosis; Neovascularization, Physiologic; Pyrroles; Rats; Rats, Sprague-Dawley; Stroke; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2010 |
Atorvastatin causes regression of endometriotic implants in a rat model.
Topics: Animals; Antioxidants; Atorvastatin; Disease Models, Animal; Endometriosis; Endometrium; Female; Heptanoic Acids; Pyrroles; Rats; Rats, Wistar | 2010 |
CRF-1 antagonist and CRF-2 agonist decrease binge-like ethanol drinking in C57BL/6J mice independent of the HPA axis.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Corticotropin-Releasing Hormone; Disease Models, Animal; Hormone Antagonists; Hypothalamo-Hypophyseal System; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Mifepristone; Peptide Fragments; Pyridines; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Signal Transduction; Urocortins | 2010 |
Comparison of three rapamycin dosing schedules in A/J Tsc2+/- mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors.
Topics: Angiogenesis Inhibitors; Animals; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Phytogenic; Asparaginase; Bevacizumab; Cystadenoma; Disease Models, Animal; Drug Administration Schedule; Female; Indoles; Kidney Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Nude; Mice, Transgenic; Pyrroles; Sirolimus; Sunitinib; Survival Rate; Tuberous Sclerosis; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Vincristine | 2010 |
Age-related macular degeneration: the molecular link between oxidative damage, tissue-specific inflammation and outer retinal disease: the Proctor lecture.
Topics: Animals; Autoantibodies; Awards and Prizes; Complement Activation; Disease Models, Animal; DNA Adducts; Florida; Humans; Macular Degeneration; Ophthalmology; Oxidative Stress; Propionates; Pyrroles; Retinal Drusen; Retinal Pigment Epithelium; Societies, Scientific | 2010 |
Atorvastatin induces apoptosis in vitro and slows growth of tumor xenografts but not polyp formation in MIN mice.
Topics: Animals; Apoptosis; Atorvastatin; Colonic Neoplasms; Colonic Polyps; Disease Models, Animal; DNA Fragmentation; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoblotting; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Nude; Pyrroles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2010 |
A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration.
Topics: Animals; Complement Fixation Tests; Disease Models, Animal; Docosahexaenoic Acids; Haptens; Humans; Macular Degeneration; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Pyrroles; Retina; Serum Albumin | 2010 |
Marrow-derived MSCs and atorvastatin improve cardiac function in rat model of AMI.
Topics: Animals; Atorvastatin; Bone Marrow; Combined Modality Therapy; Disease Models, Animal; Heptanoic Acids; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Myocardial Infarction; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; Ventricular Function | 2011 |
Heparin binding epidermal growth factor in renal ischaemia/reperfusion injury.
Topics: Adult; Aged; Animals; Cells, Cultured; Disease Models, Animal; Epidermal Growth Factor; Female; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Kidney; Kidney Transplantation; Male; Mice; Middle Aged; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Reperfusion Injury; RNA, Messenger; Up-Regulation; Young Adult | 2010 |
Atorvastatin reduces plaque vulnerability in an atherosclerotic rabbit model by altering the 5-lipoxygenase pathway.
Topics: 5-Lipoxygenase-Activating Proteins; Animals; Anticholesteremic Agents; Arachidonate 5-Lipoxygenase; Atorvastatin; Carotid Stenosis; Carrier Proteins; Disease Models, Animal; Elastic Tissue; Enzyme-Linked Immunosorbent Assay; Gene Expression; Heptanoic Acids; Leukotriene D4; Lipids; Lipoxins; Membrane Proteins; Muscle, Smooth, Vascular; Pyrroles; Rabbits; Receptors, Leukotriene; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tunica Intima | 2010 |
Atorvastatin reduces tissue damage in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation.
Topics: Animals; Antioxidants; Atorvastatin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glutathione; Heptanoic Acids; Ischemia; Lipid Peroxidation; Ovary; Peroxidase; Pyrroles; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase | 2010 |
Effect of atorvastatin on dendritic cells of tubulointerstitium in diabetic rats.
Topics: Animals; Anti-Inflammatory Agents; Atorvastatin; Cell Movement; Dendritic Cells; Diabetes Mellitus, Experimental; Disease Models, Animal; Heptanoic Acids; Nephritis, Interstitial; P-Selectin; Pyrroles; Rats | 2010 |
Activation of 5-HT1B receptors inhibits the vasodepressor sensory CGRPergic outflow in pithed rats.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Heart Rate; Hexamethonium; Infusions, Intravenous; Male; Methoxamine; Piperidones; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Sodium Chloride; Spinal Cord; Spiro Compounds; Time Factors; Vasoconstrictor Agents | 2010 |
Atorvastatin preconditioning attenuates the production of endothelin-1 and prevents experimental vasospasm in rats.
Topics: Animals; Atorvastatin; Disease Models, Animal; Endothelin-1; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Preconditioning; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrroles; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Treatment Outcome; Vasodilation; Vasospasm, Intracranial | 2010 |
Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors.
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Corticotropin-Releasing Hormone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Hyperalgesia; Indomethacin; Inflammation; Male; Mice; Pain; Pain Threshold; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Spinal Cord Injuries; Stomach Ulcer; Stress, Psychological | 2010 |
Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats.
Topics: Adrenergic Antagonists; Animals; Carbazoles; Carvedilol; Disease Models, Animal; Hypertension, Pulmonary; Indoles; Male; Propanolamines; Pulmonary Circulation; Pyrroles; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Ventricular Dysfunction, Right; Ventricular Remodeling | 2010 |
Inhibition of corneal neovascularization by topical bevacizumab (Anti-VEGF) and Sunitinib (Anti-VEGF and Anti-PDGF) in an animal model.
Topics: Administration, Topical; Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Corneal Neovascularization; Disease Models, Animal; Fluorescein Angiography; Indoles; Male; Ophthalmic Solutions; Platelet-Derived Growth Factor; Pyrroles; Rabbits; Random Allocation; Sunitinib; Vascular Endothelial Growth Factor A | 2010 |
The influence of atorvastatin on tendon healing: an experimental study on rabbits.
Topics: Achilles Tendon; Administration, Oral; Animals; Atorvastatin; Disease Models, Animal; Dose-Response Relationship, Drug; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Orthopedic Procedures; Pyrroles; Rabbits; Tendon Injuries; Treatment Outcome; Wound Healing | 2010 |
VSV oncolysis in combination with the BCL-2 inhibitor obatoclax overcomes apoptosis resistance in chronic lymphocytic leukemia.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; Female; Genetic Therapy; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Mice, SCID; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; Vesiculovirus | 2010 |
Therapeutic effect of IL-12/23 and their signaling pathway blockade on brain ischemia model.
Topics: Animals; Antibodies, Monoclonal; Brain Ischemia; Disease Models, Animal; Humans; Immunologic Memory; Interleukin-12; Interleukin-17; Interleukin-23; Janus Kinase 3; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrimidines; Pyrroles; T-Lymphocytes | 2010 |
The immunocytokine F8-IL2 improves the therapeutic performance of sunitinib in a mouse model of renal cell carcinoma.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Renal Cell; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Indoles; Interleukin-2; Kidney Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Pyrroles; Recombinant Fusion Proteins; Sunitinib | 2010 |
Microwave induced solubility enhancement of poorly water soluble atorvastatin calcium.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Biological Availability; Calcium; Chemistry, Pharmaceutical; Crystallization; Disease Models, Animal; Dosage Forms; Heptanoic Acids; Hypercholesterolemia; Male; Microwaves; Polyethylene Glycols; Polymers; Pyrroles; Rats; Rats, Wistar; Solubility | 2010 |
Effect of atorvastatin on angiogenesis in degenerated intervertebral disc in rat.
Topics: Angiogenesis Inducing Agents; Animals; Atorvastatin; Biomarkers; Disease Models, Animal; Heptanoic Acids; Immunohistochemistry; Intervertebral Disc; Intervertebral Disc Degeneration; Male; Neovascularization, Physiologic; Pyrroles; Rats; Rats, Wistar; Time Factors; von Willebrand Factor | 2011 |
Effect atorvastatin on serum tumor necrosis factor alpha and interleukin-1β following acute pulmonary embolism.
Topics: Animals; Atorvastatin; Disease Models, Animal; Female; Heptanoic Acids; Interleukin-1beta; Male; Pulmonary Embolism; Pyrroles; Rabbits; Tumor Necrosis Factor-alpha | 2011 |
Effect on ex vivo platelet aggregation and in vivo cyclic flow with Na+/H+ exchange inhibition: Gumina, NHE-1 inhibition and platelet aggregation.
Topics: Animals; Benzamides; Blood Flow Velocity; Blood Platelets; Disease Models, Animal; Dogs; Femoral Artery; Humans; Mesylates; Platelet Aggregation; Pyrroles; Sodium-Hydrogen Exchangers | 2011 |
Effects of atorvastatin and losartan on monocrotaline-induced pulmonary artery remodeling in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Arterioles; Atorvastatin; Base Sequence; Calcium Channels, L-Type; Disease Models, Animal; DNA Primers; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Inositol 1,4,5-Trisphosphate Receptors; Losartan; Male; Monocrotaline; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2010 |
Reduction of liver fructokinase expression and improved hepatic inflammation and metabolism in liquid fructose-fed rats after atorvastatin treatment.
Topics: Animals; Atorvastatin; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cyclic AMP-Dependent Protein Kinases; Dietary Carbohydrates; Disease Models, Animal; Down-Regulation; Fatty Acids; Fatty Liver; Fructokinases; Fructose; Gene Expression Regulation; Hepatitis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertriglyceridemia; I-kappa B Proteins; Inflammation Mediators; Lipid Metabolism; Liver; Male; Metallothionein; Necrosis; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Triglycerides | 2011 |
Atorvastatin prevents ischemic limb loss in type 2 diabetes: role of p53.
Topics: Animals; Atorvastatin; Blotting, Western; Cells, Cultured; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Extremities; Heart; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin Resistance; Ischemia; Male; Mice; Myoblasts; Peripheral Arterial Disease; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-mdm2; Pyrroles; Tumor Suppressor Protein p53; Ubiquitin; Wound Healing | 2011 |
Atorvastatin inhibits plaque development and adventitial neovascularization in ApoE deficient mice independent of plasma cholesterol levels.
Topics: Angiogenesis Inhibitors; Animals; Apolipoproteins E; Atherosclerosis; Atorvastatin; Cell Line; Cell Proliferation; Cholesterol; Connective Tissue; Disease Models, Animal; Endothelial Cells; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Knockout; Microvessels; Neovascularization, Pathologic; Platelet Endothelial Cell Adhesion Molecule-1; Pyrroles; Time Factors | 2011 |
EC144, a synthetic inhibitor of heat shock protein 90, blocks innate and adaptive immune responses in models of inflammation and autoimmunity.
Topics: Adaptive Immunity; Animals; Autoimmune Diseases; Cell Line; Cell Line, Transformed; Crystallography, X-Ray; Disease Models, Animal; Female; HSP90 Heat-Shock Proteins; Humans; Immunity, Innate; Immunosuppressive Agents; Inflammation; Inflammation Mediators; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Pyrimidines; Pyrroles; Rats | 2011 |
Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injury.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Cholesterol, Dietary; Choline; Choline Deficiency; Disease Models, Animal; Disease Susceptibility; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Fatty Liver; Glutathione; Heptanoic Acids; Lipotropic Agents; Liver; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Mitochondria; Obesity; Pyrroles; Quinuclidines; Reperfusion Injury | 2011 |
Development and characterization of clinically relevant tumor models from patients with renal cell carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Disease Models, Animal; DNA Fingerprinting; Everolimus; Female; Humans; Immunosuppressive Agents; Indoles; Kidney Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Polymorphism, Single Nucleotide; Pyrroles; Sirolimus; Sunitinib; Transfection; Tumor Cells, Cultured; von Hippel-Lindau Disease; Xenograft Model Antitumor Assays | 2011 |
Augmentation of chemotherapeutic infusion effect by TSU-68, an oral targeted antiangiogenic agent, in a rabbit VX2 liver tumor model.
Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Doxorubicin; Drug Therapy, Combination; Ethiodized Oil; Indoles; Infusions, Intravenous; Liver Neoplasms, Experimental; Neovascularization, Pathologic; Oxindoles; Propionates; Pyrroles; Rabbits; Statistics, Nonparametric; Tomography, X-Ray Computed | 2012 |
Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action.
Topics: Alzheimer Disease; Animals; Antioxidants; Atorvastatin; Brain; Cholesterol; Disease Models, Animal; Dogs; Female; Heptanoic Acids; Male; Nitroso Compounds; Oxidative Stress; Pyrroles; Random Allocation | 2011 |
Effect of Atorvastatin in radiographic density on alveolar bone loss in wistar rats.
Topics: Alveolar Bone Loss; Analysis of Variance; Animals; Atorvastatin; Bone Density; Disease Models, Animal; Dose-Response Relationship, Drug; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Maxilla; Periodontitis; Pyrroles; Radiography, Dental, Digital; Rats; Rats, Wistar; Statistics, Nonparametric | 2010 |
Synthesis and molecular modeling studies of anti-inflammatory active 1H-pyrrolizine-5-carboxamides.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Disease Models, Animal; Edema; Female; Heterocyclic Compounds; Inflammation; Male; Models, Molecular; Pyrroles; Rats; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship | 2011 |
Comparison of fibrate, ezetimibe, low- and high-dose statin therapy for the dyslipidemia of the metabolic syndrome in a mouse model.
Topics: Animals; Atorvastatin; Azetidines; Disease Models, Animal; Dose-Response Relationship, Drug; Dyslipidemias; Ezetimibe; Fenofibrate; Heptanoic Acids; Hypolipidemic Agents; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Pyrroles | 2011 |
Licofelone attenuates quinolinic acid induced Huntington like symptoms: possible behavioral, biochemical and cellular alterations.
Topics: Animals; Behavior, Animal; Biochemical Phenomena; Corpus Striatum; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Huntington Disease; Lipid Peroxidation; Lipoxygenase Inhibitors; Male; Mitochondria; Motor Activity; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Pyrroles; Quinolinic Acid; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2011 |
Pleiotropic stromal effects of vascular endothelial growth factor receptor 2 antibody therapy in renal cell carcinoma models.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Carcinoma, Renal Cell; Disease Models, Animal; Drug Interactions; Female; Humans; Hypoxia-Inducible Factor 1; Indoles; Kidney Neoplasms; Lymphatic Vessels; Mice; Mice, Nude; Mutation; Neoplasm Transplantation; Neovascularization, Pathologic; Pericytes; Pyrroles; Stromal Cells; Sunitinib; Tumor Burden; Tumor Cells, Cultured; Vascular Endothelial Growth Factor Receptor-2; Von Hippel-Lindau Tumor Suppressor Protein | 2011 |
Small molecule inhibitor of type I transforming growth factor-β receptor kinase ameliorates the inhibitory milieu in injured brain and promotes regeneration of nigrostriatal dopaminergic axons.
Topics: Animals; Antigens; Axons; Brain Injuries; Cicatrix; Corpus Striatum; Disease Models, Animal; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Leukocyte Common Antigens; Male; Mice; Mice, Inbred ICR; Nerve Regeneration; Protein Serine-Threonine Kinases; Proteoglycans; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Substantia Nigra; Tyrosine 3-Monooxygenase | 2011 |
Combination of amlodipine and atorvastatin synergistically reduces leukocyte recruitment to mechanically injured mouse femoral artery.
Topics: Adoptive Transfer; Amlodipine; Animals; Atorvastatin; Calcium Channel Blockers; Cell Adhesion; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Femoral Artery; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukocytes; Leukocytes, Mononuclear; Male; Mice; Mice, Inbred C57BL; NADPH Oxidases; Oxidative Stress; Pyrroles | 2011 |
Synergistic protection against vascular inflammation with a calcium channel blocker and a statin.
Topics: Amlodipine; Animals; Atorvastatin; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Femoral Artery; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukocytes; Mice; Pyrroles; Vasculitis | 2011 |
Protection against ischemic stroke damage by synergistic treatment with amlodipine plus atorvastatin in Zucker metabolic rat.
Topics: Amlodipine; Animals; Atorvastatin; Brain Ischemia; Calcium Channel Blockers; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nerve Degeneration; Neuroprotective Agents; Pyrroles; Rats; Rats, Zucker; Stroke | 2011 |
[Effect of atorvastatin on MMP-9 and TIMP-1 levels in bronchoalveolar lavage fluid and serum of rats with bleomycin-induced pulmonary fibrosis].
Topics: Animals; Atorvastatin; Bleomycin; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; Heptanoic Acids; Matrix Metalloproteinase 9; Pulmonary Fibrosis; Pyrroles; Rats; Rats, Wistar; Tissue Inhibitor of Metalloproteinase-1 | 2011 |
Atorvastatin improved scopolamine-induced impairment in memory acquisition in mice: involvement of nitric oxide.
Topics: Animals; Arginine; Atorvastatin; Cholinergic Antagonists; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Heptanoic Acids; Learning Disabilities; Memory; Memory Disorders; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pyrroles; Scopolamine | 2011 |
The role of atorvastatin in regulating the immune response leading to vascular damage in a model of Kawasaki disease.
Topics: Animals; Antigens, Bacterial; Arteritis; Atorvastatin; Cell Wall; Coronary Aneurysm; Coronary Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Induction; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunologic Factors; Lacticaseibacillus casei; Lymphocyte Activation; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mevalonic Acid; Mice; Mice, Inbred C57BL; Mucocutaneous Lymph Node Syndrome; Pyrroles; Specific Pathogen-Free Organisms; Superantigens; Tumor Necrosis Factor-alpha | 2011 |
Antitumor effect of sunitinib against skeletal metastatic renal cell carcinoma through inhibition of osteoclast function.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Bone Neoplasms; Carcinoma, Renal Cell; Cell Proliferation; Collagen Type I; Disease Models, Animal; Female; Humans; Indoles; Kidney Neoplasms; Macrophage Colony-Stimulating Factor; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Osteoclasts; Peptides; Pyrroles; Sunitinib; Vascular Endothelial Growth Factor A | 2012 |
Anxiety states induced by post-weaning social isolation are mediated by CRF receptors in the dorsal raphe nucleus.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anxiety; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Peptide Fragments; Pyrimidines; Pyrroles; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Social Isolation | 2011 |
Why does atorvastatin inhibit renal crystal retention?
Topics: Animals; Atorvastatin; Calcium Oxalate; Catalase; Crystallization; Disease Models, Animal; Heptanoic Acids; Kidney; Kidney Calculi; Male; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidases; Pyrroles; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; Rats, Wistar; Superoxide Dismutase; Transforming Growth Factor beta | 2011 |
Suppression of choroidal neovascularization by intravitreal injection of liposomal SU5416.
Topics: Angiogenesis Inhibitors; Animals; Carbocyanines; Choroidal Neovascularization; Dextrans; Disease Models, Animal; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Indoles; Intravitreal Injections; Liposomes; Male; Oligopeptides; Protein-Tyrosine Kinases; Pyrroles; Rats; Rats, Inbred BN | 2011 |
Translational medicine: Cancer lessons from mice to humans.
Topics: Animals; Clinical Trials, Phase III as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Everolimus; Humans; Indoles; Mice; Neuroendocrine Tumors; Pancreatic Neoplasms; Pyrroles; Signal Transduction; Sirolimus; Sunitinib; Survival Rate; Translational Research, Biomedical | 2011 |
Atorvastatin and pitavastatin protect cerebellar Purkinje cells in AD model mice and preserve the cytokines MCP-1 and TNF-α.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Atorvastatin; Chemokine CCL2; Disease Models, Animal; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Mice; Mice, Transgenic; Purkinje Cells; Pyrroles; Quinolines; Tumor Necrosis Factor-alpha | 2011 |
The effect of atorvastatin and its role on systemic cytokine network in treatment of acute experimental colitis.
Topics: Acute Disease; Animals; Atorvastatin; Colitis; Cytokines; Disease Models, Animal; Down-Regulation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunologic Factors; Mice; Mice, Inbred BALB C; Pyrroles; Th1 Cells; Th2 Cells | 2011 |
S35972, a direct-acting thrombin inhibitor with high oral bioavailability and antithrombotic efficacy.
Topics: Administration, Oral; Animals; Anticoagulants; Benzimidazoles; Biological Availability; Blood Coagulation Tests; Dabigatran; Disease Models, Animal; Dogs; Drug Evaluation; Humans; In Vitro Techniques; Inhibitory Concentration 50; Pyrazines; Pyridines; Pyrroles; Rats; Thrombin; Thrombosis | 2011 |
Sunitinib inhibits postoperative adhesions in a rabbit model.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Female; Indoles; Microvessels; Protein Kinase Inhibitors; Pyrroles; Rabbits; Receptor Protein-Tyrosine Kinases; Sunitinib; Tensile Strength; Tissue Adhesions; Uterus; Wounds and Injuries | 2011 |
The beneficial effects of statin therapy may not apply to all forms of crescentic glomerulonephritis.
Topics: Animals; Atorvastatin; Disease Models, Animal; Glomerulonephritis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pyrroles; Rats; Rats, Inbred WKY; Simvastatin | 2011 |
Chemopreventive efficacy and mechanism of licofelone in a mouse lung tumor model via aspiration.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Biological Assay; Biomarkers, Tumor; Disease Models, Animal; Disease Progression; Drug Delivery Systems; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Models, Chemical; Pyrroles | 2011 |
Role of hematopoietic prostaglandin D synthase in biphasic nasal obstruction in guinea pig model of experimental allergic rhinitis.
Topics: Animals; Benzimidazoles; Dinoprostone; Disease Models, Animal; Eosinophils; Guinea Pigs; Histamine; Humans; Intramolecular Oxidoreductases; Leukotrienes; Lipocalins; Male; Nasal Lavage Fluid; Nasal Mucosa; Nasal Obstruction; Ovalbumin; Prostaglandin D2; Pyrroles; Rhinitis; Time Factors | 2011 |
Involvement of CRF2 receptor in the brain regions in restraint-induced anorexia.
Topics: Animals; Anorexia; Disease Models, Animal; Dose-Response Relationship, Drug; Feeding Behavior; Male; Microinjections; Peptide Fragments; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Restraint, Physical; Septal Nuclei; Septum of Brain | 2011 |
Inhibitory effects of SU5416, a selective vascular endothelial growth factor receptor tyrosine kinase inhibitor, on experimental corneal neovascularization.
Topics: Angiogenesis Inhibitors; Animals; Cautery; Corneal Neovascularization; Disease Models, Animal; Indoles; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Pyrroles; Silver Nitrate; Vascular Endothelial Growth Factor Receptor-2 | 2012 |
Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arthritis; Binding Sites; Crystallography, X-Ray; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Mice; Mitogen-Activated Protein Kinase 14; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyrroles; Rats; Structure-Activity Relationship; Triazines | 2011 |
Effects of dexamethasone and atorvastatin on atrial sodium current and its early tachycardia-induced electrical remodeling in rabbits.
Topics: Animals; Atorvastatin; Cardiac Pacing, Artificial; Cardiotonic Agents; Dexamethasone; Disease Models, Animal; Heart Atria; Heptanoic Acids; Membrane Potentials; Patch-Clamp Techniques; Pyrroles; Rabbits; Sodium Channels; Tachycardia | 2011 |
Drug repurposing for vascular protection after acute ischemic stroke.
Topics: Animals; Anticholesteremic Agents; Antihypertensive Agents; Atorvastatin; Benzimidazoles; Biphenyl Compounds; Brain Infarction; Diabetes Mellitus, Type 2; Disease Models, Animal; Enalapril; Enzyme-Linked Immunosorbent Assay; Functional Laterality; Hemoglobins; Hemorrhage; Heptanoic Acids; Male; Matrix Metalloproteinase 9; Pyrroles; Rats; Rats, Inbred SHR; Rats, Wistar; Reperfusion; Stroke; Tetrazoles; Vascular System Injuries | 2011 |
Atorvastatin treatment during epileptogenesis in a rat model for temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Atorvastatin; Blood-Brain Barrier; Brain; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Heptanoic Acids; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Seizures; Triglycerides | 2011 |
Effect of atorvastatin therapy on oxidant-antioxidant status and atherosclerotic plaque formation.
Topics: Animals; Antioxidants; Aorta; Aortic Diseases; Aryldialkylphosphatase; Atherosclerosis; Atorvastatin; Catalase; Disease Models, Animal; Erythrocytes; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipid Peroxidation; Lipoproteins, LDL; Male; Oxidation-Reduction; Plaque, Atherosclerotic; Pyrroles; Rabbits; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors | 2011 |
[A dyslipidemia animal model induced by poloxamer 407 in golden hamsters and pilot study on the mechanism].
Topics: Animals; Anticholesteremic Agents; Atorvastatin; CD36 Antigens; Cricetinae; Disease Models, Animal; Dyslipidemias; Fenofibrate; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Lipid Metabolism; Liver; Male; Malondialdehyde; Mesocricetus; Nitric Oxide; Phosphatidylcholine-Sterol O-Acyltransferase; Poloxamer; PPAR alpha; Pyrroles; RNA, Messenger; Superoxide Dismutase | 2011 |
Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain.
Topics: Analysis of Variance; Anilides; Animals; Ankyrins; Antineoplastic Agents, Phytogenic; Capsaicin; Carbazoles; Central Nervous System; Cinnamates; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Estrenes; Gene Expression Regulation; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Neuralgia; Oligopeptides; Paclitaxel; Pain Measurement; Physical Stimulation; Protein Kinase C; Pyrroles; Pyrrolidinones; Receptor, PAR-2; Sulfonamides; Time Factors; TRPV Cation Channels; Tryptases; Type C Phospholipases | 2011 |
Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain.
Topics: Aldehydes; Alzheimer Disease; Animals; Anticholesteremic Agents; Atorvastatin; Brain; Cognition Disorders; Disease Models, Animal; Dogs; Glutathione; Heme Oxygenase-1; Heptanoic Acids; Ketocholesterols; Linear Models; Liver; Oxidative Stress; Pyrroles; Up-Regulation | 2012 |
Divergent actions by inhibitors of DP IV and APN family enzymes on CD4+ Teff cell motility and functions.
Topics: Animals; CD13 Antigens; CD4-Positive T-Lymphocytes; Cells, Cultured; Chemokine CXCL12; Chemotaxis; Dipeptidyl Peptidase 4; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Humans; Hydroxamic Acids; Lymphocyte Activation; Lysine; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Pyrroles; Pyrrolidines; Thiazoles; Transgenes | 2011 |
Environmental enrichment has antidepressant-like action without improving learning and memory deficits in olfactory bulbectomized rats.
Topics: Analysis of Variance; Animals; Avoidance Learning; Body Weight; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Environment; Exercise Therapy; Exploratory Behavior; Indoles; Learning Disabilities; Locomotion; Maze Learning; Memory Disorders; Olfactory Bulb; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Recognition, Psychology; RNA, Messenger; Time Factors; Vascular Endothelial Growth Factor A | 2012 |
The effects of AEB071 (sotrastaurin) with tacrolimus on rat heterotopic cardiac allograft rejection and survival.
Topics: Acute Disease; Animals; Disease Models, Animal; Drug Therapy, Combination; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Kidney; Liver; Male; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Rats; Rats, Inbred BN; Rats, Inbred Lew; Tacrolimus; Transplantation, Heterotopic; Transplantation, Homologous | 2011 |
Complementary information from magnetic resonance imaging and (18)F-fluoromisonidazole positron emission tomography in the assessment of the response to an antiangiogenic treatment in a rat brain tumor model.
Topics: Angiogenesis Inhibitors; Animals; Biological Transport; Brain; Brain Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cerebrovascular Circulation; Disease Models, Animal; Glioma; Indoles; Kinetics; Magnetic Resonance Imaging; Misonidazole; Neovascularization, Pathologic; Permeability; Positron-Emission Tomography; Pyrroles; Rats; Sunitinib; Treatment Outcome | 2011 |
[Atorvastatin induced increase in homologous angiotensin I converting enzyme (ACE2) mRNA is associated to decreased fibrosis and decreased left ventricular hypertrophy in a rat model of diabetic cardiomyopathy].
Topics: Animals; Atorvastatin; Diabetic Cardiomyopathies; Disease Models, Animal; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy, Left Ventricular; Male; Peptidyl-Dipeptidase A; Pyrroles; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2011 |
Sunitinib inhibits tumor vascularity and growth but does not affect Akt and ERK phosphorylation in xenograft tumors.
Topics: Angiogenesis Inhibitors; Angiogenic Proteins; Animals; Cell Growth Processes; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Female; HEK293 Cells; Humans; Indoles; Mice; Mice, Inbred NOD; Mice, SCID; Microvessels; Neoplasms, Experimental; Neovascularization, Pathologic; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrroles; Random Allocation; Sunitinib; Xenograft Model Antitumor Assays | 2011 |
Discovery of potent and novel S-nitrosoglutathione reductase inhibitors devoid of cytochrome P450 activities.
Topics: Aldehyde Oxidoreductases; Animals; Asthma; Benzamides; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Imidazoles; Lung; Mice; Molecular Structure; Molecular Targeted Therapy; No-Observed-Adverse-Effect Level; Pyrroles; Receptors, Opioid, delta; S-Nitrosoglutathione; Structure-Activity Relationship | 2011 |
A novel murine model of severe pulmonary arterial hypertension.
Topics: Acute Disease; Animals; Blotting, Western; Cytokines; Disease Models, Animal; Echocardiography; Female; Fluorescent Antibody Technique; Gene Expression Profiling; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Indoles; Lung; Male; Mice; Mice, Inbred C57BL; Pyrroles; Receptors, Vascular Endothelial Growth Factor | 2011 |
Antinociception induced by atorvastatin in different pain models.
Topics: Animals; Atorvastatin; Disease Models, Animal; Dose-Response Relationship, Drug; Heptanoic Acids; Hot Temperature; Male; Mice; Pain; Pain Measurement; Pyrroles | 2011 |
Evaluation of anti-inflammatory, anti-nociceptive, and anti-ulcerogenic activities of novel synthesized thiazolyl and pyrrolyl steroids.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Carrageenan; Disease Models, Animal; Edema; Inflammation; Pain; Pyrroles; Rats; Rats, Sprague-Dawley; Steroids; Stomach Ulcer; Thiazoles; Ulcer | 2011 |
Regression of established hepatocellular carcinoma is induced by chemoimmunotherapy in an orthotopic murine model.
Topics: Adenocarcinoma; Adoptive Transfer; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; CD8-Positive T-Lymphocytes; Combined Modality Therapy; Disease Models, Animal; Hep G2 Cells; Hepatocytes; Humans; Immune Tolerance; Immunocompetence; Indoles; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pyrroles; STAT3 Transcription Factor; Sunitinib | 2012 |
Everolimus and sunitinib: from mouse models to treatment of pancreatic neuroendocrine tumors.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinoma, Neuroendocrine; Disease Models, Animal; Everolimus; Humans; Indoles; Mice; Pancreatic Neoplasms; Pyrroles; Sirolimus; Sunitinib; TOR Serine-Threonine Kinases | 2011 |
Mycophenolate mofetil but not atorvastatin attenuates atherosclerosis in lupus-prone LDLr(-/-) mice.
Topics: Animals; Atherosclerosis; Atorvastatin; CD4-Positive T-Lymphocytes; Cholesterol; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Genetic Predisposition to Disease; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunity, Cellular; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Mice; Mice, Inbred C57BL; Mycophenolic Acid; Pyrroles | 2012 |
Progressive neurovascular disturbances in the cerebral cortex of Alzheimer's disease-model mice: protection by atorvastatin and pitavastatin.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Atorvastatin; Blotting, Western; Cerebral Cortex; Cerebrovascular Circulation; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; Female; Fluorescent Antibody Technique; Heptanoic Acids; Humans; Immunohistochemistry; Matrix Metalloproteinase 9; Mice; Mice, Transgenic; Neuroprotective Agents; Pyrroles; Quinolines | 2011 |
Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response.
Topics: Animals; Apoptosis; Atorvastatin; Caspase 12; Cells, Cultured; Disease Models, Animal; Endoplasmic Reticulum Stress; Female; Heart Failure; Heat-Shock Proteins; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; Myocardial Infarction; Natriuretic Peptide, Brain; Pyrroles; Rats; Rats, Wistar; Transcription Factor CHOP | 2011 |
Efficacy of Atorvastatin combined with adipose-derived mesenchymal stem cell transplantation on cardiac function in rats with acute myocardial infarction.
Topics: Adipose Tissue; Animals; Atorvastatin; bcl-2-Associated X Protein; Cell Differentiation; Cell Proliferation; Cells, Cultured; Coculture Techniques; Disease Models, Animal; GATA4 Transcription Factor; Heart Function Tests; Heptanoic Acids; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Myocardial Infarction; Myocytes, Cardiac; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Rats; Rats, Sprague-Dawley; Troponin I; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2011 |
An anticholinergic reverses motor control and corticostriatal LTD deficits in Dyt1 ΔGAG knock-in mice.
Topics: Animals; Calcium Channel Agonists; Corpus Striatum; Disease Models, Animal; Dystonia Musculorum Deformans; Gene Knock-In Techniques; Humans; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Mice; Mice, Transgenic; Molecular Chaperones; Muscarinic Antagonists; Pyrroles; Receptors, Dopamine D2; Trihexyphenidyl | 2012 |
Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury.
Topics: Animals; Cardiac Output; Coronary Occlusion; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Heart; Heart Failure; Indoles; Maleimides; Myocardial Contraction; Myocardial Infarction; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Pyrroles; Stroke Volume; Swine | 2011 |
Anti-inflammatory and anti-thrombotic intervention strategies using atorvastatin, clopidogrel and knock-down of CD40L do not modify radiation-induced atherosclerosis in ApoE null mice.
Topics: Animals; Anti-Inflammatory Agents; Apolipoproteins E; Atherosclerosis; Atorvastatin; Carotid Arteries; CD40 Antigens; Clopidogrel; Disease Models, Animal; Heptanoic Acids; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Aggregation Inhibitors; Pyrroles; Radiation Dosage; Radiation Injuries, Experimental; Random Allocation; Reference Values; Statistics, Nonparametric; Ticlopidine | 2011 |
Effects of atorvastatin on pathological changes in brain tissue and plasma MMP-9 in rats with intracerebral hemorrhage.
Topics: Animals; Atorvastatin; Brain; Brain Edema; Cerebral Hemorrhage; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Matrix Metalloproteinase 9; Neuroprotective Agents; Pyrroles; Rats; Rats, Wistar; Water | 2012 |
HIF-VEGF pathways are critical for chronic otitis media in Junbo and Jeff mouse mutants.
Topics: Animals; Blister; Body Fluids; Cell Hypoxia; Disease Models, Animal; Ear, Middle; Gene Expression Regulation; Hearing Loss; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Nitroimidazoles; Otitis Media with Effusion; Phthalazines; Pyridines; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor A | 2011 |
VEGF regulates antidepressant effects of lamotrigine.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Exploratory Behavior; Food Preferences; Frontal Lobe; Hippocampus; Indoles; Lamotrigine; Male; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Stress, Psychological; Sucrose; Sweetening Agents; Triazines; Vascular Endothelial Growth Factor A | 2012 |
The interactions of atorvastatin and fluvastatin with carbamazepine, phenytoin and valproate in the mouse maximal electroshock seizure model.
Topics: Animals; Anticonvulsants; Atorvastatin; Brain; Carbamazepine; Disease Models, Animal; Drug Interactions; Electroshock; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Indoles; Male; Memory; Mice; Motor Activity; Phenytoin; Pyrroles; Seizures; Valproic Acid | 2012 |
Myeloperoxidase inhibition ameliorates multiple system atrophy-like degeneration in a transgenic mouse model.
Topics: Aged; alpha-Synuclein; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gliosis; Humans; Male; Mice; Mice, Transgenic; Microglia; Middle Aged; Motor Activity; Multiple System Atrophy; Nerve Degeneration; Peroxidase; Pyrimidinones; Pyrroles | 2012 |
Sunitinib inhibits the phosphorylation of platelet-derived growth factor receptor β in the skin of mice with scleroderma-like features and prevents the development of the disease.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Disease Progression; Fibroblasts; Indoles; Mice; Phosphorylation; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Receptors, Vascular Endothelial Growth Factor; Scleroderma, Systemic; Skin; Sunitinib | 2012 |
Atorvastatin treatment is effective when used in combination with mefloquine in an experimental cerebral malaria murine model.
Topics: Animals; Antimalarials; Apoptosis; Atorvastatin; Brain; Disease Models, Animal; Drug Therapy, Combination; Female; Heptanoic Acids; Histocytochemistry; Immunohistochemistry; Malaria, Cerebral; Mefloquine; Mice; Neurons; Plasmodium berghei; Pyrroles; Survival Analysis; Treatment Outcome | 2012 |
Probucol and atorvastatin in combination protect rat brains in MCAO model: upregulating Peroxiredoxin2, Foxo3a and Nrf2 expression.
Topics: Animals; Atorvastatin; Body Fluids; Brain; Disease Models, Animal; Drug Therapy, Combination; Forkhead Box Protein O3; Forkhead Transcription Factors; Heptanoic Acids; Infarction, Middle Cerebral Artery; Male; NF-E2-Related Factor 2; Peroxiredoxins; Probucol; Pyrroles; Rats; Up-Regulation; Water | 2012 |
Transforming growth factor-β induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction.
Topics: Animals; Cell Line; Disease Models, Animal; Fibroblasts; Fibrosis; Humans; Kidney Tubules; Lymphangiogenesis; Macrophages; Male; Membrane Glycoproteins; Mice; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptor, Transforming Growth Factor-beta Type I; Receptors, Cell Surface; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transforming Growth Factor beta1; Up-Regulation; Ureteral Obstruction; Vascular Endothelial Growth Factor C | 2012 |
Corticotropin-releasing factor modulation of forebrain GABAergic transmission has a pivotal role in the expression of anabolic steroid-induced anxiety in the female mouse.
Topics: Acoustic Stimulation; Action Potentials; Amygdala; Analysis of Variance; Androgens; Animals; Anxiety; Corticotropin-Releasing Hormone; Disease Models, Animal; Dose-Response Relationship, Drug; Female; GABAergic Neurons; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Injections, Intraventricular; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Prosencephalon; Proto-Oncogene Proteins c-fos; Pyrimidines; Pyrroles; RNA, Messenger; Sensory Gating; Time Factors | 2012 |
Protective effect of atorvastatin on bone tissue in orchidectomised male albino Wistar rats.
Topics: Animals; Atorvastatin; Biomarkers; Bone and Bones; Bone Density; Bone Density Conservation Agents; Calcium; Compressive Strength; Disease Models, Animal; Femur; Heptanoic Acids; Male; Orchiectomy; Osteoporosis; Pyrroles; Rats; Rats, Wistar; Tibia | 2012 |
Influence of atorvastatin and carboxymethylated glucan on the serum lipoprotein profile and MMP activity of mice with lipemia induced by poloxamer 407.
Topics: Animals; Atorvastatin; beta-Glucans; Biomarkers; Cholesterol, LDL; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Lipoproteins; Lipoproteins, LDL; Liver; Male; Matrix Metalloproteinases; Mice; Mice, Inbred ICR; Poloxamer; Pyrroles; Scattering, Small Angle; Time Factors; Triglycerides; X-Ray Diffraction | 2012 |
Nitric oxide enhances the anti-inflammatory and anti-atherogenic activity of atorvastatin in a mouse model of accelerated atherosclerosis.
Topics: Animals; Anti-Inflammatory Agents; Anticholesteremic Agents; Atherosclerosis; Atorvastatin; Disease Models, Animal; Heptanoic Acids; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Pyrroles; Receptors, LDL | 2012 |
N⁴-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.
Topics: Animals; Binding Sites; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Drug Design; Humans; Indoles; Mice; Mice, Nude; Molecular Dynamics Simulation; Neoplasms; Oxindoles; Propionates; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Transplantation, Heterologous; Vascular Endothelial Growth Factor Receptor-2 | 2012 |
Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model.
Topics: Animals; Beclomethasone; Breast Neoplasms; Cell Movement; Cell Transformation, Neoplastic; Disease Models, Animal; Endothelial Cells; Humans; Indoles; Mice; Myeloid Cells; Neoplasm Metastasis; Neutrophils; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Sunitinib; Xenograft Model Antitumor Assays; Zebrafish | 2012 |
Chronic administration of atorvastatin induced anti-convulsant effects in mice: the role of nitric oxide.
Topics: Analysis of Variance; Animals; Anticonvulsants; Atorvastatin; Convulsants; Disease Models, Animal; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Guanidines; Heptanoic Acids; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Pyrroles; Seizures; Time Factors | 2012 |
Normalization of the lymph node T cell stromal microenvironment in lpr/lpr mice is associated with SU5416-induced reduction in autoantibodies.
Topics: Animals; Antibodies, Antinuclear; Autoantibodies; B-Lymphocytes; Cellular Microenvironment; Disease Models, Animal; Immunophenotyping; Indoles; Lupus Erythematosus, Systemic; Lymph Nodes; Mice; Mice, Inbred MRL lpr; Pyrroles; Receptors, Vascular Endothelial Growth Factor; T-Lymphocytes | 2012 |
Atorvastatin protects obese mice against hepatic ischemia-reperfusion injury by Toll-like receptor-4 suppression and endothelial nitric oxide synthase activation.
Topics: Administration, Oral; Animals; Atorvastatin; Cell Adhesion Molecules; Cytokines; Cytoprotection; Disease Models, Animal; Down-Regulation; Drug Administration Schedule; Enzyme Activation; Fatty Liver; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intravenous; Liver; Male; Mice; Mice, Obese; NF-kappa B; Nitric Oxide Synthase Type III; Non-alcoholic Fatty Liver Disease; Obesity; Pyrroles; Reperfusion Injury; RNA, Messenger; Thromboxane B2; Time Factors; Toll-Like Receptor 4 | 2012 |
The addition of Sunitinib to radiation delays tumor growth in a murine model of glioblastoma.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Disease Models, Animal; Disease Progression; Glioblastoma; Indoles; Mice; Mice, Transgenic; Pyrroles; Radiation Dosage; Sunitinib | 2012 |
Risk of tuberculosis reactivation with tofacitinib (CP-690550).
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Immunologic Factors; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Piperidines; Pyrimidines; Pyrroles; Tuberculosis | 2012 |
The effect of herb-partition moxibustion on Toll-like receptor 4 in rabbit aorta during atherosclerosis.
Topics: Animals; Anticholesteremic Agents; Antigens; Aorta; Atherosclerosis; Atorvastatin; Diet, High-Fat; Disease Models, Animal; Heptanoic Acids; Magnoliopsida; Moxibustion; Plant Preparations; Polymerase Chain Reaction; Pyrroles; Rabbits; Random Allocation; RNA, Messenger; Toll-Like Receptor 4 | 2012 |
Antidepressant effects of fibroblast growth factor-2 in behavioral and cellular models of depression.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Bromodeoxyuridine; Depressive Disorder; Disease Models, Animal; Fibroblast Growth Factor 2; Fluoxetine; Imipramine; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neuroglia; Prefrontal Cortex; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Fibroblast Growth Factor; Stress, Psychological | 2012 |
Repression of malignant tumor progression upon pharmacologic IGF1R blockade in a mouse model of insulinoma.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Immunoblotting; In Situ Nick-End Labeling; Insulinoma; Mice; Mice, Transgenic; Oligonucleotide Array Sequence Analysis; Pancreatic Neoplasms; Phosphorylation; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Reverse Transcriptase Polymerase Chain Reaction; Tumor Burden | 2012 |
Effects of atorvastatin on expression of ICAM-1 in atherosclerotic rabbits.
Topics: Animals; Atherosclerosis; Atorvastatin; Disease Models, Animal; Gene Expression Regulation; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Intercellular Adhesion Molecule-1; Male; Pyrroles; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2013 |
Low-dose atorvastatin, losartan, and particularly their combination, provide cardiovascular protection in isolated rat heart and aorta.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Atorvastatin; Biomarkers; Blood Pressure; Coronary Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Heart; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Losartan; Male; Myocardial Reperfusion Injury; Perfusion; Pyrroles; Rats; Rats, Wistar; Time Factors; Vasodilation; Vasodilator Agents | 2013 |
Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Benzamides; Benzenesulfonates; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Imatinib Mesylate; In Vitro Techniques; Indoles; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; Piperazines; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Sorafenib; Sunitinib; Vascular Endothelial Growth Factor A | 2012 |
Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models.
Topics: Adenocarcinoma; Angiogenesis Inhibitors; Animals; Antibodies, Anti-Idiotypic; Disease Models, Animal; Drug Therapy, Combination; Genetic Engineering; Indoles; Kaplan-Meier Estimate; Lung Neoplasms; Mice; Neoplasm Metastasis; Neuroendocrine Tumors; Pancreatic Neoplasms; Proto-Oncogene Proteins p21(ras); Pyrroles; Small Cell Lung Carcinoma; Sunitinib; Vascular Endothelial Growth Factor A | 2012 |
Fgf-dependent glial cell bridges facilitate spinal cord regeneration in zebrafish.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Bromodeoxyuridine; Cell Differentiation; Cell Movement; Cell Proliferation; Dextrans; Disease Models, Animal; Enzyme Inhibitors; Fibroblast Growth Factor 2; Fibroblast Growth Factor 3; Fibroblast Growth Factor 8; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Humans; Intermediate Filament Proteins; Ki-67 Antigen; Mitogen-Activated Protein Kinase Kinases; Motor Activity; Nerve Regeneration; Nerve Tissue Proteins; Nestin; Neuroglia; Pyrroles; Receptor, Fibroblast Growth Factor, Type 1; Recovery of Function; Rhodamines; RNA, Messenger; Signal Transduction; Spinal Cord Injuries; Time Factors; Zebrafish; Zebrafish Proteins | 2012 |
Thrombin activity associated with neuronal damage during acute focal ischemia.
Topics: Amino Acids; Analysis of Variance; Animals; Antithrombins; Arginine; Avoidance Learning; Brain Injuries; Cell Death; Cognition Disorders; Disease Models, Animal; Factor X; Fibrinolysin; Gene Expression Regulation; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Male; Maze Learning; Motor Activity; Nerve Tissue Proteins; Pipecolic Acids; Pyrroles; Rats; Reaction Time; Receptor, PAR-1; Sulfonamides; Thrombin; Time Factors | 2012 |
Sunitinib malate provides activity against murine bladder tumor growth and invasion in a preclinical orthotopic model.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Humans; Indoles; Mice; Mice, Inbred C3H; Neoplasm Invasiveness; Pyrroles; Sunitinib; Urinary Bladder Neoplasms | 2012 |
Deleterious effects of high concentrations of (-)-epigallocatechin-3-gallate and atorvastatin in mice with colon inflammation.
Topics: Animals; Atorvastatin; Azoxymethane; Catechin; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gastrointestinal Hemorrhage; Heptanoic Acids; Leukotriene B4; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Pyrroles; Rectum; Weight Loss | 2012 |
Atorvastatin and pitavastatin reduce senile plaques and inflammatory responses in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Atorvastatin; Brain; Disease Models, Animal; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Inflammation; Mice; Mice, Transgenic; Plaque, Amyloid; Pyrroles; Quinolines | 2012 |
Efficacy of sequential treatment with sunitinib-everolimus in an orthotopic mouse model of renal cell carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cell Line, Tumor; Disease Models, Animal; Drug Administration Schedule; Everolimus; Female; Indoles; Kidney Neoplasms; Luciferases; Luminescent Measurements; Mice; Mice, Inbred BALB C; Pyrroles; Random Allocation; Sirolimus; Sunitinib | 2012 |
Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms.
Topics: Amphetamine; Analysis of Variance; Animals; Atorvastatin; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Glutathione; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Male; Malondialdehyde; Mitochondria; Motor Activity; NADH Dehydrogenase; Nitrites; Oxidopamine; Parkinsonian Disorders; Pyrroles; Rats; Rats, Wistar; Simvastatin; Tetrazolium Salts; Thiazoles; Tumor Necrosis Factor-alpha | 2012 |
Statins have therapeutic potential for the treatment of Alzheimer's disease, likely via protection of the neurovascular unit in the AD brain.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Anticholesteremic Agents; Atorvastatin; Cholesterol; Collagen Type IV; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glial Fibrillary Acidic Protein; Glucosamine; Heptanoic Acids; Humans; Matrix Metalloproteinase 9; Maze Learning; Methylcellulose; Mice; Mice, Transgenic; Mutation; Pyrroles; Quinolines | 2012 |
Severe pulmonary arterial hypertension induced by SU5416 and ovalbumin immunization.
Topics: Animals; Antilymphocyte Serum; Apoptosis; Asparagine; B-Lymphocytes; Caspase Inhibitors; Cell Proliferation; Dexamethasone; Disease Models, Animal; Hemodynamics; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Immunization; Indoles; Interleukin-6; Lung; Male; Ovalbumin; Proliferating Cell Nuclear Antigen; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A | 2012 |
Lab reports and cat scans: can veterinary oncology guide our way to new treatments for human cancers?
Topics: Animals; Antineoplastic Agents; Benzamides; Breast Neoplasms; Cats; Disease Models, Animal; Dogs; Female; Humans; Imatinib Mesylate; Indoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mast-Cell Sarcoma; Neoplasms; Piperazines; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Thiazoles; Transcriptome | 2012 |
Differential effects of acute morphine, and chronic morphine-withdrawal on obsessive-compulsive behavior: inhibitory influence of CRF receptor antagonists on chronic morphine-withdrawal.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Morphine; Motor Activity; Narcotics; Obsessive-Compulsive Disorder; Peptide Fragments; Peptides, Cyclic; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome | 2012 |
Sunitinib reduces recurrent pelvic adhesions in a rabbit model.
Topics: Animals; Disease Models, Animal; Female; Indoles; Postoperative Complications; Protein Kinase Inhibitors; Pyrroles; Rabbits; Recurrence; Sunitinib; Tissue Adhesions; Uterus | 2012 |
Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Hedgehog Proteins; Humans; Kruppel-Like Transcription Factors; Medulloblastoma; Mice; Mice, Nude; Models, Molecular; Molecular Structure; NIH 3T3 Cells; Pyridines; Pyrroles; RNA, Messenger; Signal Transduction; Solubility; Structure-Activity Relationship; Transplantation, Homologous; Zinc Finger Protein GLI1 | 2012 |
JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production.
Topics: Animals; Arthritis, Experimental; Bone Resorption; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Female; Humans; Janus Kinases; Macrophages; Monocytes; Osteoclasts; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; RANK Ligand; Rats; Rats, Inbred Lew; Signal Transduction; T-Lymphocytes | 2012 |
The involvement of nitric oxide in the anti-seizure effect of acute atorvastatin treatment in mice.
Topics: Animals; Anticonvulsants; Atorvastatin; Brain; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Enzyme Inhibitors; Epilepsy, Tonic-Clonic; Guanidines; Heptanoic Acids; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Pyrroles | 2012 |
Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors.
Topics: Animals; Arthritis, Rheumatoid; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Humans; In Vitro Techniques; Inflammation; Interleukin-6; Janus Kinases; Macrophages; Mice; Mice, Inbred C57BL; NF-kappa B; NFATC Transcription Factors; Nitriles; Piperidines; Proto-Oncogene Proteins c-jun; Pyrazoles; Pyrimidines; Pyrroles; Signal Transduction; STAT1 Transcription Factor; Synovial Membrane; Tumor Necrosis Factor-alpha | 2012 |
The dual cyclooxygenase/5-lipoxygenase inhibitor licofelone attenuates p-glycoprotein-mediated drug resistance in the injured spinal cord.
Topics: Animals; Arachidonate 5-Lipoxygenase; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Disease Models, Animal; Drug Resistance; Enzyme Inhibitors; Gene Knockout Techniques; Male; Mice; Mice, Knockout; Neuroprotective Agents; Prostaglandin-Endoperoxide Synthases; Pyrroles; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Recovery of Function; Riluzole; Spinal Cord Injuries; Tissue Array Analysis | 2013 |
The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins.
Topics: Animals; Atorvastatin; Cell Communication; Disease Models, Animal; Endothelial Cells; Gene Expression; Hepatic Stellate Cells; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Portal; Kruppel-Like Transcription Factors; Liver; Liver Circulation; Liver Cirrhosis, Experimental; Lovastatin; Male; Paracrine Communication; Pyrroles; Rats; Rats, Wistar; Simvastatin; Stress, Mechanical | 2013 |
Atorvastatin increases oxidative stress and modulates angiogenesis in Ossabaw swine with the metabolic syndrome.
Topics: Angiogenesis Inducing Agents; Angiogenic Proteins; Animals; Atorvastatin; Biomarkers; Collateral Circulation; Coronary Circulation; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Peroxidation; Male; Metabolic Syndrome; Microvessels; Myocardial Ischemia; Myocardial Perfusion Imaging; Myocardium; Neovascularization, Physiologic; Oxidative Stress; Pyrroles; Signal Transduction; Swine; Swine, Miniature; Vasodilation; Vasodilator Agents | 2012 |
FOXO1 impairs whereas statin protects endothelial function in diabetes through reciprocal regulation of Kruppel-like factor 2.
Topics: Animals; Atorvastatin; Base Sequence; Binding Sites; Blood Glucose; Cells, Cultured; Chromatin Immunoprecipitation; Cytoprotection; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation; Heptanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kruppel-Like Transcription Factors; Male; Mevalonic Acid; Molecular Sequence Data; Nerve Tissue Proteins; Nitric Oxide Synthase Type III; Phosphorylation; Promoter Regions, Genetic; Pyrroles; Rats; Rats, Inbred OLETF; RNA Interference; Time Factors; Transfection; Vasodilation; Vasodilator Agents | 2013 |
BDNF/TrkB signaling augments smooth muscle cell proliferation in pulmonary hypertension.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Hypoxia; Cell Proliferation; Disease Models, Animal; DNA; Early Growth Response Protein 1; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Indoles; Ligands; Lung; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Monocrotaline; Myocytes, Smooth Muscle; Protein Binding; Pyrroles; Rats; Receptor, trkB; Signal Transduction | 2012 |
Investigations regarding the utility of prodigiosenes to treat leukemia.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Leukemia; Molecular Structure; Neoplasms, Experimental; Prodigiosin; Pyrroles; Structure-Activity Relationship; Zebrafish | 2013 |
Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression.
Topics: Animals; Benzamides; Disease Models, Animal; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Imatinib Mesylate; Indoles; Mice; Mice, Knockout; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Serotonin; Tryptophan Hydroxylase | 2013 |
Neuroprotective effect of atorvastatin involves suppression of TNF-α and upregulation of IL-10 in a rat model of intracerebral hemorrhage.
Topics: Animals; Atorvastatin; Behavior, Animal; Brain Edema; Cerebral Hemorrhage; Disease Models, Animal; Heptanoic Acids; Interleukin-10; Male; Microglia; Neuroprotective Agents; Pyrroles; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Up-Regulation | 2013 |
Vasa vasorum and plaque progression, and responses to atorvastatin in a rabbit model of atherosclerosis: contrast-enhanced ultrasound imaging and intravascular ultrasound study.
Topics: Animals; Atorvastatin; Carotid Artery Diseases; Carotid Artery, Common; Cell Proliferation; Contrast Media; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Image Enhancement; Male; Plaque, Atherosclerotic; Pyrroles; Rabbits; Ultrasonography, Interventional; Vasa Vasorum | 2013 |
High-dose supplementation with natural α-tocopherol does neither alter the pharmacodynamics of atorvastatin nor its phase I metabolism in guinea pigs.
Topics: alpha-Tocopherol; Animals; Anticholesteremic Agents; Atorvastatin; Blotting, Western; Cholesterol; Cytochrome P-450 CYP3A; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Guinea Pigs; Heptanoic Acids; Liver; Pyrroles; Random Allocation | 2013 |
Protective effects of TGF-β inhibitors in a rat model of NMDA-induced retinal degeneration.
Topics: Animals; Benzamides; Capillaries; Dioxoles; Disease Models, Animal; Intravitreal Injections; Male; N-Methylaspartate; Pyrazoles; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Transforming Growth Factor beta; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; Transforming Growth Factor beta | 2013 |
Establishment and characterization of a novel xenograft model of human gastrointestinal stromal tumor in mice.
Topics: Aged; Animals; Benzamides; Disease Models, Animal; Esophageal Neoplasms; Exons; Gastrointestinal Stromal Tumors; Gene Expression Regulation, Neoplastic; Humans; Imatinib Mesylate; Indoles; Male; Mice; Molecular Targeted Therapy; Mutation; Piperazines; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Sunitinib; Transplantation, Heterologous | 2013 |
Tofacitinib, a janus kinase inhibitor demonstrates efficacy in an IL-15 transgenic mouse model that recapitulates pathologic manifestations of celiac disease.
Topics: Animals; Celiac Disease; Disease Models, Animal; Female; Humans; Immunophenotyping; Interleukin-15; Intestine, Small; Janus Kinases; Killer Cells, Natural; Lymphocyte Subsets; Mice; Mice, Transgenic; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Spleen; Time Factors | 2013 |
Ro 32-0432 attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; G-Protein-Coupled Receptor Kinase 5; Indoles; Male; Maze Learning; Mecamylamine; Mice; Nicotine; Pyrroles; Substance Withdrawal Syndrome | 2013 |
Atorvastatin and rosuvastatin do not prevent thioacetamide induced liver cirrhosis in rats.
Topics: Animals; Atorvastatin; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Fluorobenzenes; Hepatic Stellate Cells; Heptanoic Acids; Hypertension, Portal; In Vitro Techniques; Incidence; Injections; Liver Cirrhosis; Liver Cirrhosis, Experimental; Male; Oxidative Stress; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Rosuvastatin Calcium; Sulfonamides; Thioacetamide | 2013 |
N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastati
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Design; Humans; Melanoma, Experimental; Mice; Mice, Nude; Microwaves; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor Protein-Tyrosine Kinases; Structure-Activity Relationship | 2013 |
Inhibition of corneal neovascularization by subconjunctival and topical bevacizumab and sunitinib in a rabbit model.
Topics: Administration, Topical; Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Bevacizumab; Conjunctiva; Corneal Neovascularization; Disease Models, Animal; Female; Immunoenzyme Techniques; Indoles; Platelet Endothelial Cell Adhesion Molecule-1; Pyrroles; Rabbits; Sunitinib; Treatment Outcome; Vascular Endothelial Growth Factor A | 2013 |
Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Gene Knockdown Techniques; Hepatic Stellate Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Liver; Liver Cirrhosis, Experimental; Male; Mice; MicroRNAs; Pyrroles; RNA Interference | 2013 |
Atorvastatin attenuates the production of IL-1β, IL-6, and TNF-α in the hippocampus of an amyloid β1-42-induced rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anticholesteremic Agents; Atorvastatin; Disease Models, Animal; Heptanoic Acids; Hippocampus; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Male; Pyrroles; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2013 |
Role of Krüppel-like factor 2 and protease-activated receptor-1 in vulnerable plaques of ApoE(-/-) mice and intervention with statin.
Topics: Animals; Apolipoproteins E; Atorvastatin; Blotting, Western; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Kruppel-Like Transcription Factors; Mice; Mice, Knockout; Plaque, Atherosclerotic; Pyrroles; Receptor, PAR-1; Reverse Transcriptase Polymerase Chain Reaction | 2013 |
Raman spectroscopic investigation of atorvastatin, amlodipine, and both on atherosclerotic plaque development in APOE*3 Leiden transgenic mice.
Topics: Amlodipine; Animals; Antihypertensive Agents; Aorta; Apolipoprotein E3; Apolipoproteins E; Arteriosclerosis; Atorvastatin; Cholesterol; Disease Models, Animal; Drug Synergism; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Transgenic; Pyrroles; Spectrum Analysis, Raman | 2002 |
Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors.
Topics: Acetates; Administration, Oral; Animals; Apoptosis; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Immunohistochemistry; Interleukin-1; Matrix Metalloproteinase 1; Nitric Oxide Synthase; Osteoarthritis; Probability; Pyrroles; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric | 2002 |
Grey matter and white matter ischemic damage is reduced by the competitive AMPA receptor antagonist, SPD 502.
Topics: Aldehydes; Animals; Brain Ischemia; Carotid Artery, External; Carotid Artery, Internal; Disease Models, Animal; Functional Laterality; Growth Inhibitors; Humans; Isoquinolines; Male; Oligodendroglia; Periaqueductal Gray; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tetrahydroisoquinolines | 2002 |
Alpha2-adrenoceptor antagonist SL 84.0418 reduces the expression of neocortical spike-and-wave spindling episodes in DBA/2J mice.
Topics: Animals; Disease Models, Animal; Electroencephalography; Indoles; Male; Mice; Mice, Inbred DBA; Neocortex; Pyrroles; Receptors, Adrenergic, alpha | 2003 |
Withdrawal of statin treatment abrogates stroke protection in mice.
Topics: Animals; Aorta; Atorvastatin; Bleeding Time; Blood Coagulation; Brain; Brain Ischemia; Disease Models, Animal; Drug Administration Schedule; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ligation; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Platelet Activation; Pyrroles; rhoA GTP-Binding Protein; RNA, Messenger; Stroke; Substance Withdrawal Syndrome; Vena Cava, Inferior; Venous Thrombosis | 2003 |
Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by up-regulating a pro-survival pathway.
Topics: Animals; Atorvastatin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardial Ischemia; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Pyrroles; Reperfusion; Signal Transduction; Time Factors; Up-Regulation | 2003 |
Pharmacodynamic-mediated effects of the angiogenesis inhibitor SU5416 on the tumor disposition of temozolomide in subcutaneous and intracerebral glioma xenograft models.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Dacarbazine; Disease Models, Animal; Drug Interactions; Glioma; Indoles; Neoplasm Transplantation; Neoplasms, Experimental; Pyrroles; Rats; Rats, Nude; Receptors, Vascular Endothelial Growth Factor; Temozolomide; Tumor Cells, Cultured | 2003 |
Increased endothelin-induced Ca2+ signaling, tyrosine phosphorylation, and coronary artery disease in diabetic dyslipidemic Swine are prevented by atorvastatin.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Calcium; Calcium Signaling; Coronary Artery Disease; Diabetes Complications; Diet; Disease Models, Animal; Endothelin-1; Endothelins; Heptanoic Acids; Hyperlipidemias; Male; Phosphorylation; Pyrroles; Receptor, Endothelin A; Receptors, Endothelin; Swine; Tyrosine | 2003 |
Lipid-lowering effects of TAK-475, a squalene synthase inhibitor, in animal models of familial hypercholesterolemia.
Topics: Administration, Oral; Animals; Atorvastatin; Cholesterol, HDL; Disease Models, Animal; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Male; Mice; Mice, Knockout; Oxazepines; Piperidines; Pyrroles; Rabbits; Receptors, LDL; Simvastatin; Species Specificity; Time Factors; Triglycerides | 2003 |
Pretreatment with statins enhances myocardial protection during coronary revascularization.
Topics: Animals; Atorvastatin; Cardiopulmonary Bypass; Disease Models, Animal; Electric Countershock; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Myocardial Ischemia; Myocardial Revascularization; Premedication; Pyrroles; Random Allocation; Swine | 2003 |
Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice.
Topics: Animals; Depression; Disease Models, Animal; Drug Therapy, Combination; Fluoxetine; Male; Mice; Mice, Inbred BALB C; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Selective Serotonin Reuptake Inhibitors; Stress, Psychological | 2003 |
Increased depression-like behaviors in corticotropin-releasing factor receptor-2-deficient mice: sexually dichotomous responses.
Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Female; Male; Mice; Mice, Neurologic Mutants; Motor Activity; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Sex Factors; Stress, Physiological; Swimming | 2003 |
Anti arthritic drugs--SMi conference: dual inhibitors. 28-29 April 2003, London, UK.
Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Arthritis; Clinical Trials as Topic; Complement Activation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Humans; Isoenzymes; Lipoxygenase Inhibitors; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrroles; Thalidomide; Tumor Necrosis Factor-alpha | 2003 |
A neutrophil elastase inhibitor reduces cigarette smoke-induced remodelling of lung vessels.
Topics: Analysis of Variance; Animals; Cell Division; Disease Models, Animal; Guinea Pigs; Hypertension, Pulmonary; Leukocyte Elastase; Lung; Muscle, Smooth, Vascular; Pyrroles; Statistics, Nonparametric; Sulfonamides; Tobacco Smoke Pollution | 2003 |
SU5416 selectively impairs angiogenesis to induce prostate cancer-specific apoptosis.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Differentiation; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinical; Gene Expression Regulation, Neoplastic; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microcirculation; Neovascularization, Pathologic; Prostatic Neoplasms; Protein-Tyrosine Kinases; Pyrroles; Up-Regulation; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2003 |
Synthesis and initial results for MAO-B inhibition by new N-propargyl-3-pyrrol-1-ylindanamine derivatives, analogues of rasagiline.
Topics: Animals; Disease Models, Animal; Indans; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinsonian Disorders; Pyrroles; Stereoisomerism; Structure-Activity Relationship | 2003 |
Development of a syngeneic in vivo tumor model and its use in evaluating a novel P-glycoprotein modulator, PGP-4008.
Topics: Acetanilides; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Line, Transformed; Disease Models, Animal; Drug Resistance, Multiple; Humans; Mice; Neoplasms, Experimental; Pyrroles; Quinolines | 2003 |
Effects of atorvastatin and pravastatin on glucose tolerance in diabetic rats mildly induced by streptozotocin.
Topics: Administration, Oral; Animals; Atorvastatin; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Glucose; Glucose Tolerance Test; Heptanoic Acids; Injections, Intravenous; Insulin; Insulin Secretion; Male; Pravastatin; Pyrroles; Rats; Rats, Sprague-Dawley; Streptozocin; Time Factors | 2003 |
Atorvastatin reduces neurological deficit and increases synaptogenesis, angiogenesis, and neuronal survival in rats subjected to traumatic brain injury.
Topics: Administration, Oral; Animals; Atorvastatin; Brain; Brain Injuries; Cell Survival; Disease Models, Animal; Heptanoic Acids; Immunohistochemistry; Male; Neovascularization, Physiologic; Neurons; Neuroprotective Agents; Pyrroles; Rats; Rats, Wistar; Synapses; Synaptophysin | 2004 |
Implication of spinal protein kinase C in the suppression of morphine-induced rewarding effect under a neuropathic pain-like state in mice.
Topics: Analgesics, Opioid; Animals; Chronic Disease; Disease Models, Animal; Enzyme Inhibitors; Indoles; Ligation; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Neuralgia; Protein Kinase C; Pyrroles; Reward; Sciatic Neuropathy; Spinal Cord; Up-Regulation | 2004 |
Antidepressant effects of citalopram and CRF receptor antagonist CP-154,526 in a rat model of depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Pyrimidines; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Corticotropin-Releasing Hormone; Social Behavior; Swimming | 2004 |
Selective blockade of D(3) dopamine receptors enhances the anti-parkinsonian properties of ropinirole and levodopa in the MPTP-lesioned primate.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benzopyrans; Brain; Callithrix; Disease Models, Animal; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Indoles; Levodopa; Parkinsonian Disorders; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D3 | 2004 |
Does amygdaloid corticotropin-releasing hormone (CRH) mediate anxiety-like behaviors? Dissociation of anxiogenic effects and CRH release.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Bombesin; Brain Chemistry; Corticotropin-Releasing Hormone; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Electroshock; Environment; Glutamic Acid; Hormone Antagonists; Male; Microdialysis; Peptide Fragments; Pyrimidines; Pyrroles; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone | 2004 |
Improvement in neurological outcome after administration of atorvastatin following experimental intracerebral hemorrhage in rats.
Topics: Animals; Atorvastatin; Brain; Cerebral Hemorrhage; Disease Models, Animal; Dose-Response Relationship, Drug; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nervous System; Pyrroles; Rats; Rats, Wistar; Recovery of Function; Severity of Illness Index; Treatment Outcome | 2004 |
Involvement of the neuropeptide corticotropin-releasing hormone in an animal model of Shigella-related seizures.
Topics: Animals; Corticotropin-Releasing Hormone; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Pyrimidines; Pyrroles; Seizures; Shigella; Time Factors | 2004 |
Behavioural effects of the novel AMPA/GluR5 selective receptor antagonist NS1209 after systemic administration in animal models of experimental pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Antagonists; Male; Morphine; Narcotics; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Kainic Acid; Tetrahydroisoquinolines; Time Factors | 2004 |
Is it time for medical therapy for aortic valve disease?
Topics: Aged; Aged, 80 and over; Animals; Aortic Valve Stenosis; Atorvastatin; Biopsy, Needle; Calcinosis; Controlled Clinical Trials as Topic; Disease Models, Animal; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hypolipidemic Agents; Immunohistochemistry; Male; Middle Aged; Practice Guidelines as Topic; Prognosis; Pyrroles; Risk Assessment; Severity of Illness Index; Survival Rate; Treatment Outcome | 2004 |
A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer.
Topics: Adenoma, Islet Cell; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Clinical Protocols; Cyclophosphamide; Disease Models, Animal; Endothelial Cells; Imatinib Mesylate; Indoles; Mice; Mice, Transgenic; Neovascularization, Pathologic; Pancreatic Neoplasms; Pericytes; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Receptors, Platelet-Derived Growth Factor; Receptors, Vascular Endothelial Growth Factor; Remission Induction; Sunitinib | 2005 |
Assessment of the efficacy of different statins in murine collagen-induced arthritis.
Topics: Animals; Arthritis, Experimental; Atorvastatin; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Fluorobenzenes; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Lymph Nodes; Male; Mice; Mice, Inbred DBA; Nuclear Proteins; Pyrimidines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Trans-Activators; Treatment Outcome | 2004 |
Attenuation of acute inflammatory response by atorvastatin after spinal cord injury in rats.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Disease Models, Animal; Female; Gliosis; Heptanoic Acids; Interleukin-1; Motor Activity; Myelitis; Necrosis; Nerve Degeneration; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oligodendroglia; Oxidative Stress; Pyrroles; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Treatment Outcome; Tumor Necrosis Factor-alpha | 2005 |
Monitoring antiproliferative responses to kinase inhibitor therapy in mice with 3'-deoxy-3'-18F-fluorothymidine PET.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Dideoxynucleosides; Disease Models, Animal; Fluorodeoxyglucose F18; Humans; Mice; Mice, SCID; Neoplasm Invasiveness; Positron-Emission Tomography; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Radiopharmaceuticals; Treatment Outcome | 2005 |
Delayed thrombosis after traumatic brain injury in rats.
Topics: Animals; Atorvastatin; Blood Coagulation Factors; Brain; Brain Injuries; Disease Models, Animal; Fibrin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracranial Thrombosis; Male; Pyrroles; Rats; Rats, Wistar; Time Factors | 2004 |
Reduction of cerebral infarction in stroke-prone spontaneously hypertensive rats by statins associated with amelioration of oxidative stress.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Atorvastatin; Blood Pressure; Body Weight; Deoxyguanosine; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Infarction, Middle Cerebral Artery; Lipids; Lysine; Oxidative Stress; Pyrroles; Quinolines; Rats; Rats, Inbred SHR; Simvastatin; Survival Analysis | 2005 |
Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia.
Topics: Animals; Atorvastatin; Brain Ischemia; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracranial Embolism; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pyrroles; Simvastatin; Stroke; Tissue Plasminogen Activator | 2005 |
Microanatomy of axon/glial signaling during Wallerian degeneration.
Topics: Analysis of Variance; Animals; Axotomy; Blotting, Western; Bromodeoxyuridine; Cell Proliferation; Cells, Cultured; Coculture Techniques; Demyelinating Diseases; Disease Models, Animal; Embryo, Mammalian; Female; Fluorescent Antibody Technique; Ganglia, Spinal; Gene Expression; Glycoproteins; Immunoprecipitation; Mitogen-Activated Protein Kinase Kinases; Myelin Basic Protein; Myelin Sheath; Neuregulins; Neuroglia; Neurons; Platelet-Derived Growth Factor; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Schwann Cells; Sciatic Neuropathy; Signal Transduction; Sodium Channels; Time Factors; Wallerian Degeneration | 2005 |
Potential role of angiotensin-converting enzyme inhibitors and statins on early podocyte damage in a model of type 2 diabetes mellitus, obesity, and mild hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Atorvastatin; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Glomerulosclerosis, Focal Segmental; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Immunoenzyme Techniques; Kidney; Kidney Glomerulus; Linear Models; Microscopy, Electron; Obesity; Pyrroles; Quinapril; Rats; Rats, Zucker; Staining and Labeling; Tetrahydroisoquinolines | 2005 |
Prevention of cardiac hypertrophy by atorvastatin in a transgenic rabbit model of human hypertrophic cardiomyopathy.
Topics: Animals; Animals, Genetically Modified; Apoptosis; Atorvastatin; Cardiomyopathy, Hypertrophic; Cholesterol; Disease Models, Animal; DNA, Mitochondrial; Extracellular Signal-Regulated MAP Kinases; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy, Left Ventricular; Male; Myocytes, Cardiac; Myosin Heavy Chains; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyrroles; Rabbits; Ventricular Function, Left | 2005 |
Effect of atorvastatin on tumor necrosis factor alpha serum concentration and mRNA expression of adipose in hypercholesterolemic rabbits.
Topics: Adipose Tissue; Animals; Anticholesteremic Agents; Atorvastatin; Body Weight; Cholesterol; Cholesterol, LDL; Disease Models, Animal; Heptanoic Acids; Hypercholesterolemia; Male; Pyrroles; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2005 |
Combined effects of HMG-CoA-reductase inhibition and renin-angiotensin system blockade on experimental atherosclerosis.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Apolipoproteins E; Atherosclerosis; Atorvastatin; Benzimidazoles; Benzoates; Chemokine CCL2; Disease Models, Animal; Drug Therapy, Combination; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Interleukin-10; Interleukin-6; Macrophages; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Monocytes; Pyrroles; Ramipril; Renin-Angiotensin System; Telmisartan | 2005 |
A centrally acting, anxiolytic angiotensin II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine binding.
Topics: Amphibian Proteins; Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Autoradiography; Behavior, Animal; Benzimidazoles; Benzodiazepines; Biphenyl Compounds; Cerebral Cortex; Disease Models, Animal; Flunitrazepam; GABA Modulators; In Situ Hybridization; Male; Maze Learning; Peptide Hormones; Peptides; Protein Binding; Pyrimidines; Pyrroles; Rats; Receptor, Angiotensin, Type 2; Receptors, Corticotropin-Releasing Hormone; RNA, Messenger; Social Isolation; Stress, Physiological; Tetrazoles; Tyrosine 3-Monooxygenase | 2006 |
Targeted chemotherapy with cytotoxic bombesin analogue AN-215 can overcome chemoresistance in experimental renal cell carcinomas.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bombesin; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Cell Transplantation; Chemokines, CC; Disease Models, Animal; Doxorubicin; Drug Resistance, Neoplasm; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Pyrroles; Receptors, Bombesin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2005 |
Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists.
Topics: Animals; Anti-Obesity Agents; Disease Models, Animal; Eating; Isoquinolines; Pyrroles; Quinolines; Radioligand Assay; Rats; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists | 2006 |
Antimalarial activities of new pyrrolo[3,2-f]quinazoline-1,3-diamine derivatives.
Topics: Animals; Antimalarials; Disease Models, Animal; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum; Pyrroles; Quinazolines | 2005 |
MDOC and atorvastatin have potential antiinflammatory effects in vascular endothelium of apoE-/- mouse model of atherosclerosis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Apolipoproteins E; Atherosclerosis; Atorvastatin; Cellulose, Oxidized; Diet; Disease Models, Animal; Endothelium, Vascular; Heptanoic Acids; Hyperlipidemias; Intercellular Adhesion Molecule-1; Lipoproteins; Male; Mice; Mice, Knockout; Pyrroles; Simvastatin; Triglycerides; Vascular Cell Adhesion Molecule-1 | 2006 |
The anxiogenic drug yohimbine reinstates palatable food seeking in a rat relapse model: a role of CRF1 receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Anxiety; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Extinction, Psychological; Food Preferences; Interpersonal Relations; Male; Pyrimidines; Pyrroles; Rats; Rats, Long-Evans; Receptors, Corticotropin-Releasing Hormone; Yohimbine | 2006 |
Cardioprotective-mimetics reduce myocardial infarct size in animals resistant to ischemic preconditioning.
Topics: Animals; Benzamides; Benzopyrans; Cardiotonic Agents; Dihydropyridines; Disease Models, Animal; Dogs; Heart; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Potassium Channels; Pyrroles; Reperfusion Injury; Sodium-Hydrogen Exchangers; Time Factors | 2005 |
Inhibition of vascular endothelial growth factor receptor 2 activity in experimental brain contusions aggravates injury outcome and leads to early increased neuronal and glial degeneration.
Topics: Angiogenesis Inhibitors; Animals; Brain Injuries; Cell Count; Cell Death; Disease Models, Animal; Female; Fluoresceins; Glial Fibrillary Acidic Protein; Immunosorbent Techniques; In Situ Hybridization; In Situ Nick-End Labeling; Indoles; Microtubule-Associated Proteins; Myelin-Associated Glycoprotein; Nerve Degeneration; Nerve Growth Factors; Neuroglia; Organic Chemicals; Pyrroles; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Time Factors; Vascular Endothelial Growth Factor Receptor-2 | 2006 |
Anti-atherosclerotic effect of amlodipine, alone and in combination with atorvastatin, in APOE*3-Leiden/hCRP transgenic mice.
Topics: Amlodipine; Animals; Apolipoprotein E3; Apolipoproteins E; Atherosclerosis; Atorvastatin; Blood Pressure; C-Reactive Protein; Cholesterol; Disease Models, Animal; Drug Therapy, Combination; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Mice; Mice, Transgenic; Pyrroles; Serum Amyloid A Protein; von Willebrand Factor | 2006 |
Immunoregulatory effects of atorvastatin on experimental autoimmune myocarditis in Lewis rats.
Topics: Adoptive Transfer; Animals; Atorvastatin; Autoimmune Diseases; Disease Models, Animal; Echocardiography; Enzyme-Linked Immunosorbent Assay; Genes, MHC Class II; Heptanoic Acids; Histocompatibility Antigens Class II; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocarditis; Myocardium; Myocytes, Cardiac; Nuclear Proteins; Polymerase Chain Reaction; Pyrroles; Rats; Rats, Inbred Lew; RNA, Messenger; T-Lymphocytes; Th2 Cells; Trans-Activators | 2006 |
Atorvastatin and glatiramer acetate: new hope in MS?
Topics: Adjuvants, Immunologic; Animals; Anticholesteremic Agents; Atorvastatin; Clinical Trials as Topic; Disease Models, Animal; Drug Therapy, Combination; Glatiramer Acetate; Heptanoic Acids; Humans; Immunotherapy; Inflammation; Multiple Sclerosis; Peptides; Pyrroles | 2006 |
New potential antimalarial agents: therapeutic-index evaluation of pyrroloquinazolinediamine and its prodrugs in a rat model of severe malaria.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Malaria; Maximum Tolerated Dose; Parasitemia; Plasmodium berghei; Prodrugs; Pyrroles; Quinazolines; Random Allocation; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Therapeutic Equivalency | 2006 |
Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity.
Topics: Acetates; Animals; Anterior Cruciate Ligament; Cartilage, Articular; Collagenases; Disease Models, Animal; Disease Progression; Dogs; Enzyme Inhibitors; Metalloproteases; Osteoarthritis, Knee; Pyrroles; Stifle | 2006 |
Facilitation of cardiac vagal activity by CRF-R1 antagonists during swim stress in rats.
Topics: Animals; Bradycardia; Cholinergic Antagonists; Corticotropin-Releasing Hormone; Death, Sudden, Cardiac; Disease Models, Animal; Exercise Tolerance; Fatigue; Heart Rate; Hypothalamo-Hypophyseal System; Hypothermia, Induced; Male; Mifepristone; Peptide Fragments; Psychomotor Agitation; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Stress, Psychological; Swimming; Vagus Nerve; Vagus Nerve Diseases | 2006 |
Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats.
Topics: Animals; Antithrombins; Arachidonic Acids; Blood Pressure; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Carbazoles; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Disease Models, Animal; Endocannabinoids; Endotoxins; Ganglia, Spinal; Gene Expression Regulation; Hypotension; Indoles; Indomethacin; Lung; Male; Neurons, Afferent; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Peptide Fragments; Polyunsaturated Alkamides; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; RNA, Messenger; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2006 |
Atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived superoxide in ischemic stroke.
Topics: Animals; Atorvastatin; Cerebral Infarction; Disease Models, Animal; Heptanoic Acids; Male; NADPH Oxidases; Neuroprotective Agents; Nitric Oxide Synthase Type II; Pyrroles; Rats; Rats, Sprague-Dawley; Superoxides; Time Factors | 2006 |
PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity.
Topics: Animals; Antineoplastic Agents; Aurora Kinase B; Aurora Kinases; Biomarkers, Tumor; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; HeLa Cells; HL-60 Cells; Humans; Inhibitory Concentration 50; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Molecular Structure; Phenotype; Phosphorylation; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction | 2006 |
Atorvastatin prevented and reversed dexamethasone-induced hypertension in the rat.
Topics: Analysis of Variance; Animals; Atorvastatin; Biomarkers; Blood Pressure; Body Weight; Dexamethasone; Disease Models, Animal; Down-Regulation; Glucocorticoids; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Organ Size; Pyrroles; Rats; Rats, Sprague-Dawley; Superoxides; Thymus Gland | 2006 |
Intracellular retention of hepatic serpins caused by severe hyperlipidemia.
Topics: Animals; Antithrombins; Atorvastatin; Chickens; Dietary Fats; Disease Models, Animal; Factor Xa Inhibitors; Fatty Liver; Heparin Cofactor II; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Intracellular Fluid; Lipid Metabolism; Lipids; Liver; Male; Pyrroles; Serpins | 2006 |
Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats.
Topics: Alcoholism; Animals; Behavior, Animal; Central Nervous System Depressants; Conditioning, Operant; Corticotropin-Releasing Hormone; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Hormone Antagonists; Male; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Self Administration; Triazines | 2007 |
A novel vascular endothelial growth factor receptor 2 inhibitor, SU11248, suppresses choroidal neovascularization in vivo.
Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Capillary Permeability; Choroidal Neovascularization; Disease Models, Animal; Disease Progression; Female; Fluorescein; Fluorescein Angiography; Indoles; Mice; Mice, Inbred C57BL; Pyrroles; Sunitinib; Vascular Endothelial Growth Factor Receptor-2 | 2006 |
The lipoxygenase-cyclooxygenase inhibitor licofelone prevents thromboxane A2-mediated cardiovascular derangement triggered by the inflammatory peptide fMLP in the rabbit.
Topics: Acetates; Animals; Aspirin; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Electrocardiography; Heart Rate; Inflammation; Lactones; Leukotriene B4; Lipoxygenase Inhibitors; Male; Myocardial Ischemia; N-Formylmethionine Leucyl-Phenylalanine; Pyrroles; Rabbits; Sulfones; Thromboxane A2; Time Factors | 2006 |
N-acetylcysteine treatment protects against VEGF-receptor blockade-related emphysema.
Topics: Acetylcysteine; Animals; Apoptosis; Disease Models, Animal; Dose-Response Relationship, Drug; Emphysema; Heme Oxygenase-1; Hypertrophy, Right Ventricular; Indoles; Lung; Male; Oxidative Stress; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor | 2004 |
Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis.
Topics: Acetates; Animals; Atherosclerosis; Chemokine CCL2; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Leukotriene B4; Lipids; Lipoxygenase Inhibitors; Macrophages; Male; NF-kappa B; Pyrroles; Rabbits; RNA, Messenger; Thromboxane B2; Tunica Intima | 2007 |
Protective effects of atorvastatin in rat models of acute pulmonary embolism: involvement of matrix metalloproteinase-9.
Topics: Acute Disease; Analysis of Variance; Animals; Atorvastatin; Disease Models, Animal; Drug Evaluation, Preclinical; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Injections, Intravenous; Luminescence; Lung; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Microspheres; Nitrates; Nitrites; Proportional Hazards Models; Pulmonary Embolism; Pulmonary Wedge Pressure; Pyrroles; Random Allocation; Rats; Rats, Wistar; Survival Rate | 2007 |
Nerve growth factor enhances voltage-gated Na+ channel activity and Transwell migration in Mat-LyLu rat prostate cancer cell line.
Topics: Animals; Carbazoles; Cell Line, Tumor; Cell Movement; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Indole Alkaloids; Indoles; Male; NAV1.7 Voltage-Gated Sodium Channel; Nerve Growth Factor; Patch-Clamp Techniques; Prostatic Neoplasms; Pyrroles; Rats; Receptors, Nerve Growth Factor; RNA, Messenger; Sodium Channels; Time Factors; Up-Regulation | 2007 |
Effect of clopidogrel on the inflammatory progression of early atherosclerosis in rabbits model.
Topics: Animals; Aspirin; Atherosclerosis; Atorvastatin; Chemokine CCL2; Clopidogrel; Diet, Atherogenic; Disease Models, Animal; Femoral Artery; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Intercellular Adhesion Molecule-1; Male; P-Selectin; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Ticlopidine; Vascular Cell Adhesion Molecule-1 | 2007 |
Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis: possible pathogenic role in plaque destabilization.
Topics: Angioplasty, Balloon, Coronary; Animals; Apolipoproteins E; Atherosclerosis; Atorvastatin; Biopsy, Needle; Cells, Cultured; Chemokine CCL19; Chemokine CCL21; Chemokines, CC; Coronary Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Gene Expression Regulation; Heptanoic Acids; Humans; Immunohistochemistry; In Vitro Techniques; Leukocytes, Mononuclear; Mice; Mice, Transgenic; Prognosis; Pyrroles; Receptors, CCR7; Receptors, Chemokine; Reference Values; Risk Factors; RNA, Messenger; Sensitivity and Specificity; Simvastatin; Treatment Outcome | 2007 |
Differential impact of atorvastatin vs pravastatin on progressive insulin resistance and left ventricular diastolic dysfunction in a rat model of type II diabetes.
Topics: Adiponectin; Adipose Tissue; Animals; Anticholesteremic Agents; Atorvastatin; Chemokine CCL2; Diabetes Mellitus, Type 2; Disease Models, Animal; Gene Expression Regulation; Glucose; Heptanoic Acids; Hypertriglyceridemia; Insulin Resistance; Leptin; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Pravastatin; Pyrroles; Rats; Rats, Long-Evans; Rats, Mutant Strains; RNA, Messenger; Transforming Growth Factor beta1; Ventricular Dysfunction, Left | 2007 |
In vivo effects of amtolmetin guacyl on lipid peroxidation and antioxidant defence systems in different models of gastrointestinal injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Disease Models, Animal; Ethanol; Gastric Mucosa; Gastrointestinal Diseases; Glycine; Indomethacin; Intestinal Mucosa; Lipid Peroxidation; Liver; Male; Pyrroles; Rats; Rats, Wistar | 2007 |
Antiarrhythmic effect of atorvastatin on autoimmune myocarditis is mediated by improving myocardial repolarization.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Atorvastatin; Autoimmune Diseases; Disease Models, Animal; Heart; Heart Ventricles; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon-gamma; Mice; Mice, Inbred BALB C; Myocarditis; Myocardium; Myocytes, Cardiac; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Tumor Necrosis Factor-alpha; Ventricular Function | 2007 |
[Hypoadiponectinemia: a cardiovascular risk factor in uremia. A view from the evidence].
Topics: Adiponectin; Animals; Atorvastatin; Cardiovascular Diseases; Coronary Restenosis; Disease Models, Animal; Heptanoic Acids; Humans; Insulin Resistance; Kidney Failure, Chronic; Peritoneal Dialysis; PPAR gamma; Prospective Studies; Pyrroles; Rats; Renal Dialysis; Risk Factors; Thiazolidinediones; Uremia | 2006 |
An arginine vasopressin V1b antagonist, SSR149415 elicits antidepressant-like effects in an olfactory bulbectomy model.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Drug Administration Schedule; Indoles; Male; Olfactory Bulb; Pyrimidines; Pyrroles; Pyrrolidines; Rats; Rats, Wistar; Statistics, Nonparametric | 2007 |
High-dose atorvastatin causes regression of endometriotic implants: a rat model.
Topics: Animals; Atorvastatin; Disease Models, Animal; Dose-Response Relationship, Drug; Endometriosis; Endometrium; Female; Heptanoic Acids; Leuprolide; Pyrroles; Rats; Rats, Wistar; Vascular Endothelial Growth Factor A | 2007 |
Effect of the pyrrolopyrimidine lipid peroxidation inhibitor U-101033E on neuronal and astrocytic metabolism and infarct volume in rats with transient middle cerebral artery occlusion.
Topics: Acetates; Animals; Astrocytes; Cerebral Infarction; Disease Models, Animal; Glucose; Glycolysis; Lipid Peroxidation; Magnetic Resonance Imaging; Male; Middle Cerebral Artery; Nerve Tissue Proteins; Neurons; Pyrimidines; Pyrroles; Pyrrolidines; Rats; Rats, Wistar | 2007 |
Aspirin before reperfusion blunts the infarct size limiting effect of atorvastatin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Atorvastatin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Membrane Proteins; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Pyrroles; Rats; Rats, Sprague-Dawley | 2007 |
Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Hippocampus; Kainic Acid; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Status Epilepticus; Tetrahydroisoquinolines; Video Recording | 2007 |
Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Disease Progression; Endothelin A Receptor Antagonists; Hypertension, Pulmonary; Hypoxia; Indoles; Intracellular Signaling Peptides and Proteins; Male; Myosin-Light-Chain Phosphatase; Organ Culture Techniques; Peptides, Cyclic; Phosphorylation; Protein Serine-Threonine Kinases; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vascular Endothelial Growth Factor Receptor-2; Vasoconstriction; Vasodilator Agents | 2007 |
Blockade of the vascular endothelial growth factor-receptor 2 pathway inhibits the growth of human renal cell carcinoma, RBM1-IT4, in the kidney but not in the bone of nude mice.
Topics: Animals; Bone and Bones; Carcinoma, Renal Cell; Cell Proliferation; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Indoles; Kidney; Kidney Neoplasms; Loss of Heterozygosity; Mice; Mutation; Oxindoles; Propionates; Pyrroles; Radiography; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; von Hippel-Lindau Disease; Von Hippel-Lindau Tumor Suppressor Protein | 2007 |
Tyrosine kinase inhibitor SU6668 represses chondrosarcoma growth via antiangiogenesis in vivo.
Topics: Angiogenesis Inhibitors; Animals; Chondrosarcoma; Disease Models, Animal; Indoles; Injections, Subcutaneous; Male; Mice; Mice, SCID; Microcirculation; Oxindoles; Propionates; Pyrroles; Treatment Outcome | 2007 |
Novel C-5 aminomethyl pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Methylamines; Mice; Models, Molecular; Molecular Structure; Neoplasm Transplantation; Protein-Tyrosine Kinases; Pyrroles; Receptor, ErbB-2; Structure-Activity Relationship; Triazines; Xenograft Model Antitumor Assays | 2007 |
Inhibition of laser-induced choroidal neovascularization by atorvastatin by downregulation of monocyte chemotactic protein-1 synthesis in mice.
Topics: Administration, Oral; Animals; Atorvastatin; Cell Movement; Chemokine CCL2; Choroidal Neovascularization; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intercellular Adhesion Molecule-1; Laser Coagulation; Macrophages; Male; Mice; Mice, Inbred C57BL; Pyrroles; Vascular Endothelial Growth Factor A | 2007 |
Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling.
Topics: Adoptive Transfer; Angiogenesis Inhibitors; Animals; Dendritic Cells; Disease Models, Animal; Endothelial Cells; Homeostasis; Hypertension, Pulmonary; Immunohistochemistry; Indoles; Injections, Subcutaneous; Male; Pyrroles; Rats; Rats, Nude; Receptors, Vascular Endothelial Growth Factor; T-Lymphocytes | 2007 |
SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts.
Topics: Androstadienes; Animals; Cardiotonic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Hirudins; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Oligopeptides; omega-N-Methylarginine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Potassium Channel Blockers; Potassium Channels; Proto-Oncogene Proteins c-akt; Pyrroles; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, PAR-1; Recombinant Proteins; Research Design; RNA, Messenger; Signal Transduction; Thrombin; Time Factors; Ventricular Function, Left; Wortmannin | 2007 |
VEGF receptor inhibition blocks liver cyst growth in pkd2(WS25/-) mice.
Topics: Animals; Cell Proliferation; Cells, Cultured; Cyst Fluid; Cysts; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial Cells; Indoles; Liver; Liver Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Polycystic Kidney, Autosomal Dominant; Protein Kinase Inhibitors; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Time Factors; TRPP Cation Channels; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2007 |
Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury.
Topics: Animals; Anti-Inflammatory Agents; Atorvastatin; Brain Edema; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Chemotaxis, Leukocyte; Cognition Disorders; Cytokines; Disease Models, Animal; Encephalitis; Endothelial Cells; Heptanoic Acids; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Pyrroles; Recovery of Function; RNA, Messenger; Simvastatin; Treatment Outcome | 2007 |
Myocardial ischaemia-reperfusion injury is attenuated by intact glucagon like peptide-1 (GLP-1) in the in vitro rat heart and may involve the p70s6K pathway.
Topics: Animals; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Glucagon-Like Peptide 1; In Vitro Techniques; Incretins; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Phosphatidylinositol 3-Kinases; Protein Kinases; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Valine | 2007 |
Pharmacological profile of novel acid pump antagonist 7-(4-fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methyl cyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine (CS-526).
Topics: Animals; Disease Models, Animal; Dogs; Enzyme Inhibitors; Esophagitis, Peptic; Gastric Acid; Gastric Mucosa; Gastrointestinal Agents; Kidney; Male; Molecular Structure; Proton Pump Inhibitors; Pyridazines; Pyrroles; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Swine | 2007 |
Effects of long-term administration of HMG-CoA reductase inhibitor, atorvastatin, on stroke events and local cerebral blood flow in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Arginine; Atorvastatin; Brain; Cerebral Arteries; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Endothelial Cells; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Lipid Metabolism; Male; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Pyrroles; Rats; Rats, Inbred SHR; Stroke; Survival Rate; Time; Time Factors; Treatment Outcome | 2007 |
The PI3K/Akt pathway mediates the neuroprotective effect of atorvastatin in extending thrombolytic therapy after embolic stroke in the rat.
Topics: Animals; Atorvastatin; Biosynthetic Pathways; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Early Growth Response Protein 1; Fibrinolytic Agents; Heptanoic Acids; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrroles; Rats; Rats, Wistar; Tissue Plasminogen Activator; Vascular Endothelial Growth Factor A | 2007 |
Atorvastatin and portal pressure.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Blood Pressure; Cholesterol; Disease Models, Animal; Dose-Response Relationship, Drug; Heptanoic Acids; Humans; Liver Cirrhosis; Pyrroles; Rats | 2007 |
Activation of fibroblast growth factor receptor by axotomy, through downstream p38 in dorsal root ganglion, contributes to neuropathic pain.
Topics: Animals; Axotomy; Behavior, Animal; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Functional Laterality; Ganglia, Spinal; Gene Expression Regulation; Male; Nerve Tissue Proteins; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Fibroblast Growth Factor; Sciatica; Time Factors | 2007 |
Preclinical pharmacology profile of CS-706, a novel cyclooxygenase-2 selective inhibitor, with potent antinociceptive and anti-inflammatory effects.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arthritis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Inflammation; Inhibitory Concentration 50; Pain; Pain Measurement; Pyrroles; Rats; Rats, Inbred Lew; Rats, Wistar; Sulfonamides | 2008 |
ST2472: a new potential antipsychotic with very low liability to induce side-effects.
Topics: Amphetamine; Analysis of Variance; Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Blood Pressure; Catalepsy; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation; Heart Rate; Hyperkinesis; Locomotion; Male; Motor Activity; Piperazines; Prolactin; Psychotic Disorders; Pyrroles; Rats; Rats, Inbred F344; Reaction Time; Statistics, Nonparametric; Stereotyped Behavior; Thiazepines | 2008 |
Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats.
Topics: Angiogenesis Inhibitors; Animals; Cells, Cultured; Disease Models, Animal; Hypertension, Portal; Indoles; Inflammation; Liver Cirrhosis; Male; Portal Pressure; Pyrroles; Rats; Rats, Wistar; Sunitinib | 2007 |
Protective effect of neutrophil elastase inhibitor (FR136706) in lethal acute liver failure induced by D-galactosamine and lipopolysaccharide in rats.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cytokines; Disease Models, Animal; Galactosamine; L-Lactate Dehydrogenase; Lipopolysaccharides; Liver; Liver Failure, Acute; Male; Neutrophil Infiltration; NF-kappa B; Nitric Oxide Synthase Type II; Proteinase Inhibitory Proteins, Secretory; Pyrroles; Rats; Rats, Sprague-Dawley | 2008 |
Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.
Topics: Alkylation; Animals; Antiparasitic Agents; Cell Line, Tumor; Combinatorial Chemistry Techniques; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Design; Duocarmycins; Indoles; Injections, Intraperitoneal; Mice; Mice, Inbred DBA; Molecular Structure; Pyrroles; Stereoisomerism; Survival Rate; Xenograft Model Antitumor Assays | 2007 |
Atorvastatin attenuates mitochondrial toxin-induced striatal degeneration, with decreasing iNOS/c-Jun levels and activating ERK/Akt pathways.
Topics: Animals; Atorvastatin; Corpus Striatum; Disease Models, Animal; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Heptanoic Acids; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mitochondria; Nerve Degeneration; Neurotoxins; Nitric Oxide Synthase Type II; Nitro Compounds; Propionates; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrroles; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley | 2008 |
Novel delivery systems of atorvastatin should be evaluated for pharmacodynamics instead of pharmacokinetics.
Topics: Administration, Oral; Animals; Atorvastatin; Disease Models, Animal; Drug Delivery Systems; Emulsions; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Liver; Pyrroles; Tissue Distribution | 2007 |
Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus.
Topics: Animals; Atorvastatin; Biopterins; Body Weight; Cell Adhesion Molecules; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; GTP Cyclohydrolase; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intramolecular Oxidoreductases; Male; Microfilament Proteins; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphoproteins; Pyrroles; Rats; Rats, Wistar; Stem Cells; Tetrahydrofolate Dehydrogenase; Vasodilation | 2008 |
Atorvastatin promotes presenilin-1 expression and Notch1 activity and increases neural progenitor cell proliferation after stroke.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Basic Helix-Loop-Helix Transcription Factors; Cell Proliferation; Disease Models, Animal; Heptanoic Acids; Homeodomain Proteins; Male; Middle Cerebral Artery; Neurons; Presenilin-1; Pyrroles; Rats; Rats, Wistar; Receptor, Notch1; Signal Transduction; Stem Cells; Stroke; Transcription Factor HES-1 | 2008 |
Simultaneous determination of blood glucose and isoleucine levels in rats after chronic alcohol exposure by microwave-assisted derivatization and isotope dilution gas chromatography/mass spectrometry.
Topics: Administration, Oral; Alcoholism; Animals; Biomarkers; Blood Glucose; Disease Models, Animal; Drug Therapy, Combination; Ethanol; Gas Chromatography-Mass Spectrometry; Isoleucine; Isotope Labeling; Male; Microwaves; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley | 2008 |
[Effects of atorvastatin on expression of peroxisome proliferation activated receptor gamma in unilateral ureteral obstruction in rats].
Topics: Animals; Atorvastatin; Disease Models, Animal; Female; Heptanoic Acids; Kidney Tubules; Nephrosclerosis; PPAR gamma; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; Ureteral Obstruction | 2007 |
Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors.
Topics: Animals; Atorvastatin; Combinatorial Chemistry Techniques; Disease Models, Animal; Fluorobenzenes; Hepatocytes; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Molecular Structure; Muscle Cells; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Sulfonamides | 2008 |
Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Imidazoles; Neuralgia; Pain Threshold; Pyrroles; Rats; Structure-Activity Relationship | 2008 |
Oral nanoparticulate atorvastatin calcium is more efficient and safe in comparison to Lipicure in treating hyperlipidemia.
Topics: Administration, Oral; Animals; Anticholesteremic Agents; Atorvastatin; Blood Glucose; Cholesterol; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Lactic Acid; Lipids; Male; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Pyrroles; Rats; Rats, Sprague-Dawley | 2008 |
Disease modifying effect of statins in dextran sulfate sodium model of mouse colitis.
Topics: Animals; Apolipoprotein A-I; Atorvastatin; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, HDL; Mice; Occult Blood; Pyrroles; Simvastatin; Tumor Necrosis Factor-alpha | 2008 |
The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; B-Lymphocytes; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Female; Flow Cytometry; Histocompatibility Antigens Class II; In Vitro Techniques; Interleukin-4; Janus Kinase 3; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin; Piperidines; Pulmonary Eosinophilia; Pyrimidines; Pyrroles; Receptors, IgE; Th2 Cells | 2008 |
[Cardioprotective effects of atorvastatin preconditioning via iNOS upregulation in a rabbit ischemia/reperfusion model].
Topics: Animals; Atorvastatin; Disease Models, Animal; Heptanoic Acids; Ischemic Preconditioning, Myocardial; Male; Myocardial Reperfusion Injury; Nitric Oxide Synthase Type II; Potassium Channels; Pyrroles; Rabbits; Up-Regulation | 2007 |
Potent antimalarial and transmission-blocking activities of centanamycin, a novel DNA-binding agent.
Topics: Alkylating Agents; Animals; Anopheles; Antimalarials; Disease Models, Animal; Duocarmycins; Female; Indoles; Mice; Oocysts; Plasmodium; Pyrroles; Sporozoites | 2008 |
Pretreatment with high-dose statin, but not low-dose statin, ezetimibe, or the combination of low-dose statin and ezetimibe, limits infarct size in the rat.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anticholesteremic Agents; Atorvastatin; Azetidines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ezetimibe; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide Synthase; Pyrroles; Rats; Rats, Sprague-Dawley; Simvastatin; Up-Regulation | 2008 |
Atorvastatin has hypolipidemic and anti-inflammatory effects in apoE/LDL receptor-double-knockout mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Apolipoproteins E; Arteriosclerosis; Atorvastatin; Blotting, Western; Chemokine CCL2; Diet, Atherogenic; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Heptanoic Acids; Hypolipidemic Agents; Intercellular Adhesion Molecule-1; Lipids; Mice; Mice, Knockout; Myocardium; Pyrroles; Receptors, LDL | 2008 |
Systemic evaluation of gene expression changes in major target organs induced by atorvastatin.
Topics: Animals; Atorvastatin; Blood Pressure; Brain; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Heart; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Kidney; Lipids; Male; Myocardium; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reproducibility of Results; RNA, Messenger; Time Factors | 2008 |
Effects of traditional chinese medicine on endotoxin and its receptors in rats with non-alcoholic steatohepatitis.
Topics: Acute-Phase Proteins; Alanine Transaminase; Animals; Atorvastatin; Carrier Proteins; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drugs, Chinese Herbal; Endotoxins; Fatty Liver; Hepatitis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Interleukin-1beta; Lipids; Lipopolysaccharide Receptors; Liver; Lymphocyte Antigen 96; Male; Membrane Glycoproteins; NF-kappa B; Nitric Oxide Synthase Type II; Polymerase Chain Reaction; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Immunologic; RNA, Messenger; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2008 |
Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats.
Topics: Animals; Blood-Brain Barrier; Chronic Disease; Colon; Corticotropin-Releasing Hormone; Disease Models, Animal; Hyperalgesia; Infusion Pumps, Implantable; Injections, Subcutaneous; Male; Mechanotransduction, Cellular; Peptide Fragments; Pressure; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Rectum; Stress, Psychological | 2008 |
Caffeinated coffee blunts the myocardial protective effects of statins against ischemia-reperfusion injury in the rat.
Topics: Administration, Oral; Animals; Atorvastatin; Blood Pressure; Caffeine; Coffee; Disease Models, Animal; Food-Drug Interactions; Heart Rate; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1 | 2008 |
Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells.
Topics: Analysis of Variance; Animals; Apoptosis; Atorvastatin; bcl-2-Associated X Protein; Blotting, Western; Caspase 9; Cells, Cultured; Disease Models, Animal; Fas Ligand Protein; Female; Flow Cytometry; Hepatocytes; Heptanoic Acids; JNK Mitogen-Activated Protein Kinases; Male; Microscopy, Confocal; NF-kappa B; Probability; Pyrroles; Rats; Rats, Wistar; Sensitivity and Specificity | 2008 |
LPK-26, a novel kappa-opioid receptor agonist with potent antinociceptive effects and low dependence potential.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Behavior, Animal; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Humans; Male; Mice; Motor Activity; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Pain; Pain Measurement; Pain Threshold; Protein Binding; Pyrroles; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors; Transfection | 2008 |
Inhibition of intra-abdominal adhesion formation with the angiogenesis inhibitor sunitinib.
Topics: Abdominal Cavity; Administration, Oral; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Indoles; Mice; Mice, Inbred C57BL; Pyrroles; Sunitinib; Tissue Adhesions; Vascular Endothelial Growth Factor Receptor-2 | 2008 |
A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Movement; Disease Models, Animal; Disease Progression; Dopamine Antagonists; Female; Humans; Male; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Pyridines; Pyrroles; Spinal Cord | 2008 |
Leukocyte, plasma, and organ-associated cytokine profiles in an animal model of acute inflammation.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atorvastatin; Cytokines; Disease Models, Animal; Down-Regulation; Endotoxemia; Female; Heart; Heptanoic Acids; Inflammation Mediators; Kidney; Leukocytes; Lipopolysaccharides; Myocardium; Organ Specificity; Pyrroles; Random Allocation; Swine; Up-Regulation | 2008 |
Synthesis and structure based optimization of novel Akt inhibitors.
Topics: Animals; Antineoplastic Agents; Combinatorial Chemistry Techniques; Crystallography, X-Ray; Disease Models, Animal; Drug Design; Inhibitory Concentration 50; Mice; Molecular Conformation; Molecular Structure; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Spiro Compounds; Structure-Activity Relationship | 2008 |
Atorvastatin enhances interleukin-10 levels and improves cardiac function in rats after acute myocardial infarction.
Topics: Animals; Atorvastatin; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Hemodynamics; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Interleukin-10; Macrophages; Male; Myocardial Infarction; Pyrroles; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Left; Ventricular Function, Left | 2009 |
The role of eNOS, iNOS, and NF-kappaB in upregulation and activation of cyclooxygenase-2 and infarct size reduction by atorvastatin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Atorvastatin; Cyclooxygenase 2; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoblotting; Janus Kinases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardium; NF-kappa B; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peptides; Phosphorylation; Protein Kinase Inhibitors; Pyrroles; Time Factors; Tyrphostins; Up-Regulation | 2008 |
Inhibition of development of experimental aortic abdominal aneurysm in rat model by atorvastatin through inhibition of macrophage migration.
Topics: Animals; Anticholesteremic Agents; Aortic Aneurysm, Abdominal; Atorvastatin; Cell Movement; Collagen; Disease Models, Animal; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Macrophages; Pancreatic Elastase; Pyrroles; Rats; Rats, Wistar; Treatment Outcome | 2009 |
Cromakalim suppresses hypertonic saline-induced renal vasoconstriction in anaesthetized dogs.
Topics: Animals; Benzopyrans; Cromakalim; Disease Models, Animal; Diuresis; Dogs; Female; Glomerular Filtration Rate; Hematocrit; Male; Potassium Channels; Pyrroles; Renal Circulation; Saline Solution, Hypertonic; Sodium; Vasoconstriction; Vasodilator Agents | 1995 |
Ventricular overdrive pacing-induced preconditioning and no-flow ischemia-induced preconditioning in isolated working rat hearts.
Topics: Animals; Benzopyrans; Blood Pressure; Cardiac Pacing, Artificial; Coronary Circulation; Cromakalim; Disease Models, Animal; Glyburide; Heart; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1995 |
Analysis of the potassium channel openers celikalim, pinacidil and cromakalim in platelet models of thrombosis.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Blood Coagulation; Cromakalim; Disease Models, Animal; Evaluation Studies as Topic; Guanidines; Humans; Indoles; Male; Molecular Structure; Pinacidil; Platelet Aggregation Inhibitors; Potassium Channels; Pyrroles; Rabbits; Stereoisomerism; Thrombosis | 1994 |
Cromakalim does not protect against skeletal muscle fatigue in an anaesthetized rat model of acute hindlimb ischaemia.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Heart Rate; Hindlimb; Ischemia; Male; Muscle Contraction; Muscles; Pyrroles; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Vasodilator Agents | 1993 |
Antiinflammatory 4,5-diarylpyrroles: synthesis and QSAR.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Disease Models, Animal; Drug Tolerance; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1994 |
In vivo bronchodilator action of a novel K+ channel opener, KC 399, in the guinea pig.
Topics: Administration, Inhalation; Albuterol; Anesthesia; Animals; Antigens; Asthma; Benzopyrans; Bronchoconstriction; Bronchodilator Agents; Consciousness; Cromakalim; Disease Models, Animal; Guinea Pigs; Histamine; Immunization; Injections, Intravenous; Male; Potassium Channels; Pyrroles | 1994 |
Therapeutic potential of potassium channel openers in peripheral vascular disease and asthma.
Topics: Animals; Asthma; Benzopyrans; Cromakalim; Cyclopentanes; Disease Models, Animal; Humans; Parasympatholytics; Peripheral Vascular Diseases; Potassium Channels; Pyrroles; Rats | 1993 |
Evaluation of the anti-inflammatory and liver-protective effects of anoectochilus formosanus, ganoderma lucidum and gynostemma pentaphyllum in rats.
Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Biopsy; Carbon Tetrachloride; Carrageenan; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Edema; Liver Diseases; Male; Pyrroles; Rats; Rats, Wistar | 1993 |
Time-dependent blockade of neurogenic plasma extravasation in dura mater by 5-HT1B/D agonists and endopeptidase 24.11.
Topics: Animals; Capsaicin; Disease Models, Animal; Dura Mater; Electric Stimulation; Extravasation of Diagnostic and Therapeutic Materials; Guinea Pigs; Indoles; Male; Neprilysin; Neuropeptides; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Serotonin Receptor Agonists; Sulfonamides; Sumatriptan; Time Factors; Trigeminal Ganglion | 1993 |
Modulation of GABA transmission by diazoxide and cromakalim in the globus pallidus: implications for the treatment of Parkinson's disease.
Topics: Animals; Antihypertensive Agents; Behavior, Animal; Benzopyrans; Cromakalim; Diazoxide; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Globus Pallidus; Ion Channel Gating; Locomotion; Male; Parkinson Disease; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Reserpine; Time Factors | 1996 |
Antidepressant-like effects of CP-154,526, a selective CRF1 receptor antagonist.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Depression; Disease Models, Animal; Helplessness, Learned; Imipramine; Injections, Intraperitoneal; Male; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone | 1997 |
KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats.
Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Calcium Channel Blockers; Coronary Disease; Cromakalim; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Glyburide; Guanidines; Heart Rate; Male; Myocardial Reperfusion Injury; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Survival Rate; Vasodilator Agents; Ventricular Fibrillation | 1997 |
Tirilazad widens the therapeutic window for riluzole-induced attenuation of progressive cortical degeneration in an infant rat model of the shaken baby syndrome.
Topics: Age Factors; Animals; Battered Child Syndrome; Body Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Free Radical Scavengers; Glutamic Acid; Head Injuries, Closed; Humans; Hypoxia; Infant; Lipid Peroxidation; Male; Nerve Degeneration; Neuroprotective Agents; Pregnatrienes; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Riluzole; Time Factors | 1998 |
A serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function after experimentally-induced murine myocarditis.
Topics: Administration, Oral; Animals; Cardiovirus Infections; Disease Models, Animal; Encephalomyocarditis virus; Fibrosis; Heart; Inflammation; Male; Mice; Mice, Inbred DBA; Microcirculation; Myocarditis; Myocardium; Perfusion; Peroxidase; Pyrroles; Serine Proteinase Inhibitors; Sulfonamides | 1998 |
HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation in a rabbit model of atherosclerosis.
Topics: Animals; Atorvastatin; Chemokine CCL2; Coronary Artery Disease; Disease Models, Animal; Evaluation Studies as Topic; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; NF-kappa B; Pyrroles; Rabbits; Random Allocation; Tunica Intima | 1998 |
A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo.
Topics: 3T3 Cells; Animals; Bone Diseases, Metabolic; Bone Resorption; Cell Adhesion Molecules; Cell Survival; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Disease Models, Animal; Enzyme Inhibitors; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Male; Mice; Oncogene Protein pp60(v-src); Osteoblasts; Ovariectomy; Paxillin; Phosphoproteins; Phosphorylation; Pregnancy; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; src-Family Kinases | 1999 |
Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent.
Topics: Animals; Antimalarials; Disease Models, Animal; Drug Evaluation, Preclinical; Gram-Negative Aerobic Bacteria; Humans; In Vitro Techniques; Indoles; Malaria; Male; Mice; Mice, Inbred ICR; Plasmodium falciparum; Pyrroles | 1999 |
Nitric oxide synthase II (NOS II) gene expression correlates with atherosclerotic intimal thickening. Preventive effects of HMG-CoA reductase inhibitors.
Topics: Animals; Arteriosclerosis; Atorvastatin; Chemokine CCL2; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; DNA; Down-Regulation; Fibrinogen; Gene Expression; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Macrophages; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Polymerase Chain Reaction; Pyrroles; Rabbits; Simvastatin; Tunica Intima | 1999 |
Discovery of subtype-selective NMDA receptor ligands: 4-benzyl-1-piperidinylalkynylpyrroles, pyrazoles and imidazoles as NR1A/2B antagonists.
Topics: Animals; Disease Models, Animal; Imidazoles; Levodopa; Ligands; Molecular Structure; Oxidopamine; Parkinsonian Disorders; Piperidines; Pyrazoles; Pyrroles; Rats; Receptors, N-Methyl-D-Aspartate | 1999 |
The antitussive activity of delta-opioid receptor stimulation in guinea pigs.
Topics: Animals; Carbazoles; Cell Line; CHO Cells; Cloning, Organism; Codeine; Cough; Cricetinae; Dextromethorphan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Humans; Hydrocodone; Levallorphan; Male; Naloxone; Narcotic Antagonists; Protein Binding; Pyridines; Pyrroles; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Synthesis and pharmacology of a novel pyrrolo[2,1,5-cd] indolizine (NNC 45-0095), a high affinity non-steroidal agonist for the estrogen receptor.
Topics: Animals; Binding, Competitive; Biological Assay; Bone Density; Cytosol; Disease Models, Animal; Drug Evaluation; Estradiol; Estrogen Replacement Therapy; Female; Indolizines; Inhibitory Concentration 50; Mice; Myometrium; Pyrroles; Rabbits; Rats; Receptors, Estrogen | 2000 |
Regression of poloxamer 407-induced atherosclerotic lesions in C57BL/6 mice using atorvastatin.
Topics: Analysis of Variance; Animals; Anticholesteremic Agents; Arteriosclerosis; Atorvastatin; Cholesterol, Dietary; Cholesterol, LDL; Culture Techniques; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Heptanoic Acids; Injections, Intraperitoneal; Liver; Mice; Mice, Inbred C57BL; Poloxamer; Pyrroles; Reference Values; Remission Induction; Triglycerides | 2000 |
Vascular endothelial growth factor in human colon cancer: biology and therapeutic implications.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Division; Colonic Neoplasms; Disease Models, Animal; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Humans; Indoles; Liver Neoplasms; Lymphokines; Mice; Neoplasm Metastasis; Neovascularization, Pathologic; Prognosis; Protein Isoforms; Protein-Tyrosine Kinases; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Mitogen; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Measuring VEGF-Flk-1 activity and consequences of VEGF-Flk-1 targeting in vivo using intravital microscopy: clinical applications.
Topics: Analysis of Variance; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Endothelial Growth Factors; Enzyme Inhibitors; Glioblastoma; Indoles; Lymphokines; Male; Mice; Mice, Nude; Microcirculation; Microscopy, Fluorescence; Microscopy, Video; Neoplasm Transplantation; Neovascularization, Pathologic; Protein Isoforms; Protein-Tyrosine Kinases; Pyrroles; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Mitogen; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Skin Neoplasms; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Administration of a targeted cytotoxic analog of luteinizing hormone-releasing hormone inhibits growth of estrogen-independent MDA-MB-231 human breast cancers in nude mice.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Disease Models, Animal; DNA Primers; Doxorubicin; Drug Delivery Systems; Female; Gonadotropin-Releasing Hormone; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Pyrroles; Radioligand Assay; Receptors, LHRH; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Specific Pathogen-Free Organisms; Tumor Cells, Cultured | 2000 |
Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Pancreatic Elastase; Protease Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides | 2000 |
p-Dimethylaminobenzaldehyde-reactive substances in tail tendon collagen of streptozotocin-diabetic rats: temporal relation to biomechanical properties and advanced glycation endproduct (AGE)-related fluorescence.
Topics: Animals; Benzaldehydes; Collagen; Diabetes Mellitus, Experimental; Disease Models, Animal; Enzyme Inhibitors; Glycation End Products, Advanced; Guanidines; Indicators and Reagents; Male; Pepsin A; Pyrroles; Rats; Rats, Wistar; Spectrophotometry; Stress, Mechanical; Tail; Tendons; Time Factors | 2000 |
Effect of SMP-300, a new Na+/H+ exchange inhibitor, on myocardial ischemia and experimental angina models in rats.
Topics: Amiloride; Angina Pectoris; Animals; Azocines; Blood Pressure; Disease Models, Animal; Electrocardiography; Heart; Heart Rate; Isoproterenol; Male; Myocardial Ischemia; Myocardium; Neuroprotective Agents; Pyrroles; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Vasopressins | 2000 |
Pharmacological properties of a newly synthesized H(+)/K(+) ATPase inhibitor, 1-(2-methyl-4-methoxyphenyl)-4-.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cysteamine; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Gastric Acid; Gastric Mucosa; H(+)-K(+)-Exchanging ATPase; Indomethacin; Omeprazole; Perfusion; Proton Pump Inhibitors; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley; Sodium Hydroxide; Stomach; Stomach Ulcer; Time Factors | 2001 |
Atorvastatin prevents glomerulosclerosis and renal endothelial dysfunction in hypercholesterolaemic rabbits.
Topics: Acetylcholine; Animals; Anticholesteremic Agents; Atorvastatin; Bridged Bicyclo Compounds, Heterocyclic; Cholesterol, Dietary; Disease Models, Animal; Endothelium, Vascular; Glomerulosclerosis, Focal Segmental; Heptanoic Acids; Hypercholesterolemia; Kidney; Male; Nitroprusside; Oxazoles; Phenylephrine; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Renal Circulation; Vasodilation | 2001 |
Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis.
Topics: Acetates; Animals; Arachidonate 5-Lipoxygenase; Arthritis, Experimental; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Lipoxygenase Inhibitors; Probability; Prostaglandin-Endoperoxide Synthases; Pyrroles; Range of Motion, Articular; Rats; Rats, Inbred Lew; Reference Values; Sensitivity and Specificity; Severity of Illness Index; Statistics, Nonparametric; Treatment Outcome | 2001 |
GV196771A, an NMDA receptor/glycine site antagonist, attenuates mechanical allodynia in neuropathic rats and reduces tolerance induced by morphine in mice.
Topics: Animals; Behavior, Animal; Binding Sites; Constriction, Pathologic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Glycine; Indoles; Ligation; Male; Mice; Morphine; Narcotics; Neuralgia; Pain; Pain Measurement; Pain Threshold; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Stress, Mechanical | 2001 |
Magnetic resonance imaging of ethyl-nitrosourea-induced rat gliomas: a model for experimental therapeutics of low-grade gliomas.
Topics: Angiogenesis Inhibitors; Animals; Brain Neoplasms; Carcinogens; Diet; Disease Models, Animal; Diterpenes; Ethylnitrosourea; Glioma; Indoles; Magnetic Resonance Imaging; Neoplasms, Multiple Primary; Neoplasms, Second Primary; Pyrroles; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Retinyl Esters; Survival Analysis; Time Factors; Vitamin A | 2001 |
Atorvastatin reduces the expression of cyclooxygenase-2 in a rabbit model of atherosclerosis and in cultured vascular smooth muscle cells.
Topics: Animals; Arteriosclerosis; Atorvastatin; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-8; Isoenzymes; Lipids; Macrophages; Male; Matrix Metalloproteinases; Muscle, Smooth, Vascular; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Protein Isoforms; Pyrroles; Rabbits; Random Allocation; Randomized Controlled Trials as Topic; Time Factors | 2002 |
Evaluation of a cyclic GMP-dependent protein kinase inhibitor in treatment of murine toxoplasmosis: gamma interferon is required for efficacy.
Topics: Animals; Antiprotozoal Agents; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Enzyme Inhibitors; Female; Immune System; Interferon-gamma; Mice; Mice, Inbred C57BL; Pyridines; Pyrroles; Toxoplasma; Toxoplasmosis; Treatment Outcome | 2002 |
Reduction in hepatic non-esterified fatty acid concentration after long-term treatment with atorvastatin lowers hepatic triglyceride synthesis and its secretion in sucrose-fed rats.
Topics: Animals; Anticholesteremic Agents; Apolipoproteins B; Atorvastatin; Coenzyme A Ligases; Dietary Sucrose; Disease Models, Animal; Down-Regulation; Fatty Acids, Nonesterified; Heptanoic Acids; Hypertriglyceridemia; Lipase; Lipoproteins, VLDL; Liver; Male; Oleic Acid; Pyrroles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Triglycerides; Tritium | 2002 |
Treatment with atorvastatin ameliorates hepatic very-low-density lipoprotein overproduction in an animal model of insulin resistance, the fructose-fed Syrian golden hamster: evidence that reduced hypertriglyceridemia is accompanied by improved hepatic ins
Topics: Animals; Apolipoproteins B; Atorvastatin; Blood Glucose; Cells, Cultured; Cholesterol; Cricetinae; Disease Models, Animal; Fructose; Hepatocytes; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertriglyceridemia; Insulin Resistance; Kinetics; Lipoproteins, VLDL; Liver; Luminescent Measurements; Mesocricetus; Phosphorylation; Pyrroles; Receptor, Insulin; Triglycerides | 2002 |
Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve.
Topics: Alkaline Phosphatase; Animals; Anticholesteremic Agents; Aortic Valve; Atorvastatin; Biomarkers; C-Reactive Protein; Calcinosis; Cell Division; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Heart Valve Diseases; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Immunohistochemistry; Macrophages; Male; Microscopy, Immunoelectron; Osteoblasts; Osteopontin; Proliferating Cell Nuclear Antigen; Pyrroles; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sialoglycoproteins | 2002 |
Corticotropin releasing hormone (CRH) antagonist attenuates adjuvant induced arthritis: role of CRH in peripheral inflammation.
Topics: Animals; Arthritis, Experimental; Corticotropin-Releasing Hormone; Disease Models, Animal; Female; Immunohistochemistry; Male; Multivariate Analysis; Probability; Pyrimidines; Pyrroles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Receptors, Corticotropin-Releasing Hormone; Reference Values; Sensitivity and Specificity; Treatment Outcome | 2002 |
Loss of striatal serotonin synaptic receptor binding induced by kainic acid lesions: correlations with Huntington's Disease.
Topics: Animals; Caudate Nucleus; Disease Models, Animal; Humans; Huntington Disease; Lysergic Acid Diethylamide; Pyrroles; Pyrrolidines; Rats; Receptors, Serotonin; Serotonin | 1977 |
Long-term efficacy of tubercidin against schistosomiasis japonica and mansoni in primates.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Feces; Haplorhini; Intestines; Liver; Male; Papio; Parasite Egg Count; Pyrimidines; Pyrroles; Ribonucleosides; Schistosoma; Schistosoma mansoni; Schistosomiasis; Schistosomicides | 1975 |
Comparison of the effects of cromakalim in trachea isolated from normal and albumin-sensitive guinea-pigs.
Topics: Acetylcholine; Albumins; Animals; Asthma; Benzopyrans; Bronchodilator Agents; Cromakalim; Disease Models, Animal; Electric Stimulation; Flurbiprofen; Guinea Pigs; Immunization; In Vitro Techniques; Male; Potassium Channels; Pyrroles; Trachea | 1992 |
[The vasospasmolytic effects of nicorandil, cromakalim and pinacidil on 3,4-diaminopyridine-induced phasic contractions in canine coronary arteries as an experimental vasospasm model].
Topics: 4-Aminopyridine; Amifampridine; Animals; Benzopyrans; Coronary Vasospasm; Cromakalim; Disease Models, Animal; Dogs; Female; Glyburide; Guanidines; In Vitro Techniques; Ion Channel Gating; Male; Methylene Blue; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
Potassium channel activators cromakalim and celikalim (WAY-120,491) fail to decrease myocardial infarct size in the anesthetized canine.
Topics: Animals; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Disease Models, Animal; Dogs; Hemodynamics; Indoles; Myocardial Infarction; Perfusion; Potassium Channels; Pyrroles; Regional Blood Flow | 1992 |
Involvement of a peripheral component in the antinociceptive effects of opioids in a model of tonic pain.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Male; Morphine; Narcotics; Pain; Peripheral Nerves; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1990 |
Alpha 2-adrenergic model of gastroparesis: validation with renzapride, a stimulator of motility.
Topics: Adrenergic alpha-Agonists; Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cresols; Disease Models, Animal; Dogs; Duodenum; Eating; Gastric Emptying; Gastrointestinal Motility; Muscle, Smooth; Paralysis; Pyrroles; Receptors, Adrenergic, alpha; Serotonin Antagonists; Stomach Diseases; Technetium Tc 99m Sulfur Colloid | 1991 |
Right ventricular hypertrophy in monocrotaline pyrrole treated rats.
Topics: Animals; Blood Platelets; Blood Pressure; Capillaries; Cardiomegaly; Disease Models, Animal; Endothelium; Erythrocyte Count; Fibrin; Hematocrit; Hemoglobins; Lung; Male; Microscopy, Electron; Muscle, Smooth; Myocardium; Organ Size; Pulmonary Circulation; Pyrroles; Pyrrolizidine Alkaloids; Rats; Time Factors | 1974 |
Effect of age on development of cor pulmonale in nonhuman primates following pyrrolizidine alkaloid intoxication.
Topics: Age Factors; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Enzymes; Female; Formaldehyde; Haplorhini; Hepatic Veins; Injections, Subcutaneous; Liver; Liver Diseases; Lung; Macaca; Male; Microsomes, Liver; Myocardium; Necrosis; Pulmonary Artery; Pulmonary Heart Disease; Pyrroles; Pyrrolizidine Alkaloids | 1972 |
[Research on compounds with psychotropic activity. II. Synthesis of 5-phenylpyrrolo-(2,1-d)-benzothiazepin-6,6-dioxide and 1,2,3,3a,4,5-hexahydro-5-phenylpyrrolo-(2,1-d) (1,5)-benzo-thiazepin-1,4-dione-6,6-dioxide derivatives and their pharmacological pro
Topics: Animals; Benzazepines; Disease Models, Animal; Male; Mice; Pyrroles; Seizures; Thiazepines; Tranquilizing Agents | 1973 |
Diaryl pyrroles: a new series of anti-inflammatory agents.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Disease Models, Animal; Edema; Erythema; Female; Guinea Pigs; Hindlimb; Injections, Subcutaneous; Male; Pyrroles; Rats | 1972 |
Uroporphyrinogen 3 cosynthetase activity in the fox squirrel (Sciurus niger).
Topics: Animals; Blood Cell Count; Disease Models, Animal; Hemoglobins; Isomerases; Kidney; Liver; Myocardium; Porphyrias; Porphyrins; Propionates; Pyrroles; Reticulocytes; Sciuridae; Spleen | 1971 |