Page last updated: 2024-08-18

pyrroles and Brain Ischemia

pyrroles has been researched along with Brain Ischemia in 58 studies

Research

Studies (58)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (10.34)	18.2507
2000's	21 (36.21)	29.6817
2010's	31 (53.45)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Benoit, SM; de la Tremblaye, PB; Plamondon, H; Schock, S	1
Cho, S; Kim, E; Park, KW; Yang, J	1
Aurigemma, C; D'Ambrosio, A; Di Sciascio, G; Giardina, A; Leporace, M; Macrì, M; Melfi, R; Patti, G; Ricottini, E; Sedati, P; Tomai, F	1
Delgado, G; Naves, M	1
Inaba, T; Kamiya, F; Katayama, Y; Katsura, K; Muraga, K; Nito, C; Saito, T; Ueda, M	1
de la Tremblaye, PB; Merali, Z; Milot, MR; Plamondon, H; Raymond, J	1
Cardona-Gómez, GP; Garcia-Segura, LM; Gutierrez-Vargas, JA; Muñoz-Manco, JI	1
Deng, J; He, J; Hu, Z; Lei, Q; Liu, J; Lu, W; Song, T; Tao, X; Zhang, J; Zheng, L	1
Deng, JG; Liu, J; Song, T; Tao, X	1
Anisimova, VA; Kosolapov, VA; Sorotskii, DV; Spasov, AA	1
Ago, T; Arimura, K; Kamouchi, M; Kitazono, T; Kuroda, J; Makihara, N; Nakamura, K; Nishimura, A; Ooboshi, H; Tachibana, M; Wakisaka, Y; Yoshikawa, Y	1
Chen, Q; Deng, G; Li, M; Li, Q; Wan, J; Wang, J; Wang, W; Wang, Y; Yang, Q	1
Freeling, JL; Lü, L; Martin, DS; Min, JW; Wang, H	1
Gonzales, RJ; Jin, WN; Li, M; Li, Z; Liu, Q; Shi, SX; Wood, K	1
Császár, A	1
Amarenco, P; Callahan, A; Goldstein, LB; Hennerici, MG; Messig, M; Sillesen, H; Welch, KM; Zivin, J	1
Hanhart, J; Koskas, P; Le Mer, Y; Obadia, M; Paques, M; Sahel, JA	1
Amarenco, P; Benavente, O; Callahan, A; Gilbert, S; Goldstein, LB; Hennerici, MG; Rudolph, AE; Sillesen, H; Simunovic, L; Welch, KM; Zivin, JA	1
El-Remessy, AB; Elewa, HF; Ergul, A; Fagan, SC; Frye, RF; Johnson, MH; Kozak, A	1
Cui, L; Li, M; Liu, L; Wang, L; Yang, R; Zhang, X	1
Cui, L; Du, W; Li, M; Liu, L; Wang, L; Yang, R; Zhang, X	1
Athyros, VG; Karagiannis, A; Mikhailidis, DP; Tziomalos, K; Wierzbicki, AS	1
Boaz, M; Gilad, R; Lampl, Y; Lorberboym, M; Sadeh, M; Tikozky, A; Vysberg, I	1
Cardona-Gómez, GP; Céspedes-Rubio, A; Jurado, FW	1
Hasegawa, E; Konoeda, F; Morita, R; Muto, G; Shichita, T; Sugiyama, Y; Suzuki, N; Yoshida, H; Yoshimura, A	1
Gaur, V; Kumar, A	1
Abe, A; Katayama, Y; Katsura, K; Nagayama, H; Nishiyama, Y; Otsuka, T; Ueda, M	1
Abe, K; Deguchi, K; Deguchi, S; Ikeda, Y; Kawai, H; Kurata, T; Matsuura, T; Ohta, Y; Omote, Y; Yamashita, T	1
Kasner, SE; Taylor, RA; Weigele, JB	1
Aout, M; Clarençon, F; Colonne, C; Fonfrede, M; Jean, B; Le Jean, L; Nouet, A; Puybasset, L; Sanchez-Peña, P; Vicaut, E	1
Beer, C; Blacker, D; Bynevelt, M; Hankey, GJ; Puddey, IB	1
Bhardwaj, A	1
Cheng, M; Feng, L; Hao, F; Ma, C; Pan, L; Tian, Y; Zhang, L	1
Chen, ZC; Lou, M; Shi, ZH; Sun, JZ	1
Ding, X; Huang, S; Li, W; Lu, X; Sun, B; Wang, B; Zhang, Y	1
Cao, X; Fang, YY; Gao, TM; Hou, FQ; Hu, HH; Li, SJ; Wang, P; Yan, HC; Zhu, XH	1
Dewar, D; Fowler, JH; McCracken, E; McCulloch, J; Morrison, S	1
Böhm, M; Dirnagl, U; Endres, M; Gertz, K; Laufs, U; Lindauer, U; Nickenig, G	1
Amin-Hanjani, S; Asahi, M; Huang, PL; Huang, Z; Liao, JK; Lo, EH; Mori, T; Moskowitz, MA; Qiu, J; Sumii, T; Thomas, S; Yoshimura, S	1
Appel, K; Fiebich, BL; Hüll, M; Kauppinen, RA; Kettunen, M; Koistinaho, J; Yrjänheikki, J	1
Chopp, M; Kapke, A; Liu, XS; Lu, M; Morris, DC; Zhang, L; Zhang, ZG	1
Berezin, VA; Bock, E; Dmitrieva, O; Klementiev, B; Lushnikova, IV; Novikova, T; Skibo, GG; Vaudano, E; Voronin, KY	1
Chopp, M; Ding, G; Ewing, JR; Jiang, Q; Li, L; Panda, S; Zhang, L; Zhang, ZG	1
Corado Ramírez, J; Eblen-Zajjurz, A; Oria de Suárez, C; Ponce Hernández, L; Suárez Rodríguez, S; Tovar Mendoza, R	1
Carod-Artal, FJ	1
Edvinsson, L; Henriksson, M; Stenman, E; Vikman, P	1
Guyton, JR; Laskowitz, DT; Lynch, JR; Mace, B; Song, P; Wang, H; Warner, DS; Yang, HJ; Yates, RB	1
Kulbertus, H	1
Blanco, M; Castellanos, M; Castillo, J; Dávalos, A; García-Gil, M; Leira, R; Lizasoain, I; Moro, MA; Nombela, F; Rodriguez-Yáñez, M; Serena, J; Vivancos, J	1
Bassi, A; Caltagirone, C; Colivicchi, F; Santini, M	1
Bertaina, V; Heurteaux, C; Lazdunski, M; Widmann, C	1
Oda, M; Yamamoto, N; Yamashita, A; Yokota, K	1
Oda, M; Yamamoto, N; Yamashita, A; Yokota, K; Yoshidomi, M	1
Carter, DB; Dunn, E; Hall, ED; Oostveen, JA	1
Barber, A; Bender, HM; Gottschlich, R; Greiner, HE; Harting, J; Mauler, F; Seyfried, CA	1
Böhm, M; Dirnagl, U; Endres, M; Gertz, K; Huang, P; Laufs, U; Nickenig, G	1
Basson, CT; Delanty, N; Vaughan, CJ	1
Hara, H; Kogure, K; Matsuda, Y; Onodera, H; Yoshidomi, M	1

Reviews

4 review(s) available for pyrroles and Brain Ischemia

Article	Year
[Important aim of statin therapy: ischemic cardiovascular event (stroke)]. Ideggyogyaszati szemle, 2008, Jul-30, Volume: 61, Issue:7-8 Topics: Acute Disease; Atorvastatin; Brain Ischemia; Cholesterol, LDL; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Meta-Analysis as Topic; Myocardial Ischemia; Pyrroles; Recurrence; Stroke	2008
Aggressive statin treatment, very low serum cholesterol levels and haemorrhagic stroke: is there an association? Current opinion in cardiology, 2010, Volume: 25, Issue:4 Topics: Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Cholesterol, LDL; Coronary Artery Disease; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Intracranial Hemorrhages; Primary Prevention; Pyrroles; Risk Factors; Secondary Prevention; Stroke	2010
Current management of symptomatic intracranial stenosis. Current atherosclerosis reports, 2011, Volume: 13, Issue:4 Topics: Angioplasty; Anticoagulants; Atorvastatin; Brain; Brain Ischemia; Cilostazol; Constriction, Pathologic; Endovascular Procedures; Fibrinolytic Agents; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracranial Arteriosclerosis; Phosphodiesterase 3 Inhibitors; Platelet Aggregation Inhibitors; Pyrroles; Stents; Stroke; Tetrazoles	2011
Statin therapy and stroke prevention. Current opinion in cardiology, 2001, Volume: 16, Issue:4 Topics: Anti-Inflammatory Agents; Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Encephalitis; Endothelium, Vascular; Fibrinolytic Agents; Heptanoic Acids; Humans; Lovastatin; Nitric Oxide Synthase; Pyrroles; Stroke	2001

Trials

5 trial(s) available for pyrroles and Brain Ischemia

Article	Year
Strategies of clopidogrel load and atorvastatin reload to prevent ischemic cerebral events in patients undergoing protected carotid stenting. Results of the randomized ARMYDA-9 CAROTID (Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting Journal of the American College of Cardiology, 2013, Apr-02, Volume: 61, Issue:13 Topics: Aged; Angioplasty, Balloon; Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Carotid Artery Diseases; Carotid Stenosis; Clopidogrel; Diffusion Magnetic Resonance Imaging; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Male; Platelet Aggregation Inhibitors; Pyrroles; Research Design; Stents; Ticlopidine; Treatment Outcome	2013
Results of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial by stroke subtypes. Stroke, 2009, Volume: 40, Issue:4 Topics: Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Cerebral Hemorrhage; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Male; Middle Aged; Placebos; Proportional Hazards Models; Pyrroles; Risk Factors; Stroke; Treatment Outcome	2009
Statin treatment decreased serum asymmetric dimethylarginine (ADMA) levels in ischemic stroke patients. Journal of atherosclerosis and thrombosis, 2011, Volume: 18, Issue:2 Topics: Aged; Aged, 80 and over; Arginine; Atherosclerosis; Atorvastatin; Brain Ischemia; Cholesterol, LDL; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Linear Models; Male; Middle Aged; Pravastatin; Prospective Studies; Pyrroles; Quinolines; Stroke	2011
A randomized placebo controlled trial of early treatment of acute ischemic stroke with atorvastatin and irbesartan. International journal of stroke : official journal of the International Stroke Society, 2012, Volume: 7, Issue:2 Topics: Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Atorvastatin; Biphenyl Compounds; Brain Ischemia; Cerebral Infarction; Disease Progression; Double-Blind Method; Female; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Irbesartan; Male; Middle Aged; Monitoring, Physiologic; Pyrroles; Sample Size; Stroke; Tetrazoles; Tomography, X-Ray Computed; Treatment Outcome	2012
Statin treatment withdrawal in ischemic stroke: a controlled randomized study. Neurology, 2007, Aug-28, Volume: 69, Issue:9 Topics: Acute Disease; Aged; Atorvastatin; Brain Ischemia; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Neuroprotective Agents; Odds Ratio; Pyrroles; Risk Factors; Stroke; Survival Analysis; Time Factors; Treatment Outcome; Withholding Treatment	2007

Other Studies

49 other study(ies) available for pyrroles and Brain Ischemia

Article	Year
CRHR1 exacerbates the glial inflammatory response and alters BDNF/TrkB/pCREB signaling in a rat model of global cerebral ischemia: implications for neuroprotection and cognitive recovery. Progress in neuro-psychopharmacology & biological psychiatry, 2017, 10-03, Volume: 79, Issue:Pt B Topics: Animals; Anxiety; Brain; Brain Ischemia; Brain-Derived Neurotrophic Factor; Central Nervous System Agents; Cognition; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Male; Neuroglia; Neuroimmunomodulation; Neuronal Plasticity; Neuroprotection; Pyrimidines; Pyrroles; Rats, Wistar; Receptor, trkB; Receptors, Corticotropin-Releasing Hormone; Recovery of Function; RNA, Messenger; Signal Transduction	2017
Inhibition of VEGF Signaling Reduces Diabetes-Exacerbated Brain Swelling, but Not Infarct Size, in Large Cerebral Infarction in Mice. Translational stroke research, 2018, Volume: 9, Issue:5 Topics: Animals; Blood Glucose; Brain Edema; Brain Ischemia; Cerebral Infarction; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucose Tolerance Test; Indoles; Insulin; Male; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; Proteoglycans; Pyrroles; RNA, Messenger; Signal Transduction; Stroke; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2018
Compliance and echographic carotid plaque evolution in patients with acute ischemic stroke treated with atorvastatin according to usual care. Vascular, 2014, Volume: 22, Issue:3 Topics: Aged; Atorvastatin; Brain Ischemia; Carotid Arteries; Carotid Artery Diseases; Cholesterol, HDL; Cholesterol, LDL; Drug Monitoring; Female; Follow-Up Studies; Heptanoic Acids; Humans; Hypolipidemic Agents; Lipid Metabolism; Male; Medication Adherence; Plaque, Atherosclerotic; Prospective Studies; Pyrroles; Spain; Stroke; Triglycerides; Ultrasonography	2014
Continuous oral administration of atorvastatin ameliorates brain damage after transient focal ischemia in rats. Life sciences, 2014, Jan-17, Volume: 94, Issue:2 Topics: Administration, Oral; Animals; Atorvastatin; Brain; Brain Edema; Brain Ischemia; DNA Damage; Heptanoic Acids; Lipid Peroxidation; Magnetic Resonance Imaging; Male; Microglia; Neuroimaging; Neuroprotective Agents; Oxidative Stress; Pyrroles; Rats; Rats, Sprague-Dawley; Time Factors; Tumor Necrosis Factor-alpha	2014
Evidence of lasting dysregulation of neuroendocrine and HPA axis function following global cerebral ischemia in male rats and the effect of Antalarmin on plasma corticosterone level. Hormones and behavior, 2014, Volume: 65, Issue:3 Topics: Animals; Behavior, Animal; Brain Ischemia; CA1 Region, Hippocampal; Central Amygdaloid Nucleus; Corticosterone; Corticotropin-Releasing Hormone; Hypothalamo-Hypophyseal System; Limbic System; Locus Coeruleus; Male; Memory, Short-Term; Neurosecretory Systems; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Receptors, Glucocorticoid; Stress, Psychological; Time Factors; Tyrosine 3-Monooxygenase	2014
GluN2B N-methyl-D-aspartic acid receptor subunit mediates atorvastatin-Induced neuroprotection after focal cerebral ischemia. Journal of neuroscience research, 2014, Volume: 92, Issue:11 Topics: Animals; Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Embryo, Mammalian; Heptanoic Acids; Male; Maze Learning; Nerve Tissue Proteins; Nervous System Diseases; Piperidines; Platelet Aggregation Inhibitors; Pyrroles; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recovery of Function; Somatosensory Cortex; Time Factors	2014
HspB8 expression in brain tissue after cerebral ischemic reperfusion and atorvastatin intervention in Sprague-Dawley rats. Neurological research, 2015, Volume: 37, Issue:3 Topics: Animals; Apoptosis; Atorvastatin; Blotting, Western; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Heat-Shock Proteins; Heptanoic Acids; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Pyrroles; Random Allocation; Rats, Sprague-Dawley; Reperfusion Injury; Severity of Illness Index; Tetrazolium Salts	2015
Protection effect of atorvastatin in cerebral ischemia-reperfusion injury rats by blocking the mitochondrial permeability transition pore. Genetics and molecular research : GMR, 2014, Dec-18, Volume: 13, Issue:4 Topics: Animals; Anticholesteremic Agents; Apoptosis; Atorvastatin; Brain Ischemia; Cytochromes c; Disease Models, Animal; Heptanoic Acids; Infarction, Middle Cerebral Artery; Male; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Pyrroles; Rats, Sprague-Dawley; Reperfusion Injury	2014
Effect of Pyrrolobenzimidazole Derivative RU-792 on Experimental Brain Ischemia. Bulletin of experimental biology and medicine, 2015, Volume: 159, Issue:3 Topics: Animals; Benzimidazoles; Brain Ischemia; Glutathione Peroxidase; Lipid Peroxidation; Male; Oxidation-Reduction; Picolines; Pyrroles; Rats	2015
Possible involvement of basic FGF in the upregulation of PDGFRβ in pericytes after ischemic stroke. Brain research, 2016, Jan-01, Volume: 1630 Topics: Animals; Brain; Brain Ischemia; Cell Hypoxia; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Fibroblast Growth Factor 2; Humans; Hydrogen-Ion Concentration; Infarction, Middle Cerebral Artery; Male; Mice, 129 Strain; Mice, Inbred C57BL; Pericytes; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Receptors, Fibroblast Growth Factor; Stroke; Up-Regulation	2016
GSK-3β inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats. Molecular neurobiology, 2016, Volume: 53, Issue:10 Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Ischemia; Cerebral Hemorrhage; Claudin-3; Glycogen Synthase Kinase 3 beta; Infarction, Middle Cerebral Artery; Male; Permeability; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Stroke; Tissue Plasminogen Activator; Wnt Signaling Pathway; Zonula Occludens-1 Protein	2016
USP14 inhibitor attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice. Journal of neurochemistry, 2017, Volume: 140, Issue:5 Topics: Animals; Behavior, Animal; Brain Ischemia; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrroles; Pyrrolidines; Recovery of Function; Reperfusion Injury; Survival Analysis; Ubiquitin Thiolesterase	2017
Depletion of microglia exacerbates postischemic inflammation and brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017, Volume: 37, Issue:6 Topics: Aminopyridines; Animals; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Inflammation Mediators; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Microglia; Neurons; Primary Cell Culture; Proto-Oncogene Proteins c-kit; Pyrroles; Reactive Oxygen Species; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor	2017
Atorvastatin reduces the risk of cardiovascular events in patients with carotid atherosclerosis: a secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial. Stroke, 2008, Volume: 39, Issue:12 Topics: Aged; Atorvastatin; Brain Ischemia; Carotid Stenosis; Cerebral Hemorrhage; Cholesterol, LDL; Coronary Disease; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Ischemic Attack, Transient; Male; Middle Aged; Pyrroles; Randomized Controlled Trials as Topic; Recurrence; Risk; Treatment Outcome	2008
[Brain hypoperfusion revealed by an ocular ischemic syndrome]. Journal francais d'ophtalmologie, 2008, Volume: 31, Issue:8 Topics: Antihypertensive Agents; Aspirin; Atorvastatin; Brain Ischemia; Carotid Artery Thrombosis; Ciliary Body; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Ischemia; Light Coagulation; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Middle Aged; Ophthalmic Artery; Platelet Aggregation Inhibitors; Pyrroles; Recurrence; Stroke; Ultrasonography	2008
Early atorvastatin reduces hemorrhage after acute cerebral ischemia in diabetic rats. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 330, Issue:2 Topics: Acute Disease; Animals; Atorvastatin; Brain Ischemia; Cerebral Hemorrhage; Diabetes Mellitus, Type 2; Drug Administration Schedule; Heptanoic Acids; Male; Pyrroles; Rats; Rats, Wistar; Time Factors	2009
Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1, HMGB1 receptors (RAGE and TLR4), NF-kappaB expression. Neuroscience letters, 2010, Mar-08, Volume: 471, Issue:3 Topics: Animals; Atorvastatin; Behavior, Animal; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Down-Regulation; Heptanoic Acids; HMGB1 Protein; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Neuroprotective Agents; NF-kappa B; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Toll-Like Receptor 4	2010
Neuroprotection of early and short-time applying atorvastatin in the acute phase of cerebral ischemia: down-regulated 12/15-LOX, p38MAPK and cPLA2 expression, ameliorated BBB permeability. Brain research, 2010, Apr-14, Volume: 1325 Topics: Acute Disease; Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Atorvastatin; Blood-Brain Barrier; Brain; Brain Edema; Brain Ischemia; Capillary Permeability; Down-Regulation; Heptanoic Acids; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Phospholipases A2, Cytosolic; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; Stroke; Time Factors	2010
Early outcome of acute ischemic stroke in hyperlipidemic patients under atorvastatin versus simvastatin. Clinical neuropharmacology, 2010, Volume: 33, Issue:3 Topics: Aged; Aged, 80 and over; Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Dose-Response Relationship, Drug; Female; Heptanoic Acids; Humans; Hyperlipidemias; Lipids; Male; Medical Records; Middle Aged; Neuroprotective Agents; Pyrroles; Retrospective Studies; Severity of Illness Index; Simvastatin; Statistics as Topic; Stroke; Stroke Rehabilitation; Treatment Outcome	2010
p120 catenin/αN-catenin are molecular targets in the neuroprotection and neuronal plasticity mediated by atorvastatin after focal cerebral ischemia. Journal of neuroscience research, 2010, Volume: 88, Issue:16 Topics: alpha Catenin; Analysis of Variance; Animals; Atorvastatin; Brain Ischemia; Catenins; Cell Adhesion Molecules; Cell Death; Cerebral Cortex; Delta Catenin; Gene Expression Regulation; Heptanoic Acids; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infarction, Middle Cerebral Artery; Longitudinal Studies; Male; Nerve Tissue Proteins; Neuronal Plasticity; Neuroprotective Agents; Protein Isoforms; Pyrroles; Rats; Rats, Wistar; Statistics, Nonparametric; Synapses	2010
Therapeutic effect of IL-12/23 and their signaling pathway blockade on brain ischemia model. Biochemical and biophysical research communications, 2010, Nov-19, Volume: 402, Issue:3 Topics: Animals; Antibodies, Monoclonal; Brain Ischemia; Disease Models, Animal; Humans; Immunologic Memory; Interleukin-12; Interleukin-17; Interleukin-23; Janus Kinase 3; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrimidines; Pyrroles; T-Lymphocytes	2010
Neuroprotective potentials of candesartan, atorvastatin and their combination against stroke induced motor dysfunction. Inflammopharmacology, 2011, Volume: 19, Issue:4 Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Atorvastatin; Behavior, Animal; Benzimidazoles; Biphenyl Compounds; Brain; Brain Ischemia; Dose-Response Relationship, Drug; Drug Therapy, Combination; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mitochondria; Motor Activity; Movement Disorders; Neurons; Organ Specificity; Oxidative Stress; Pyrroles; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Stroke; Tetrazoles	2011
Protection against ischemic stroke damage by synergistic treatment with amlodipine plus atorvastatin in Zucker metabolic rat. Brain research, 2011, Mar-25, Volume: 1382 Topics: Amlodipine; Animals; Atorvastatin; Brain Ischemia; Calcium Channel Blockers; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nerve Degeneration; Neuroprotective Agents; Pyrroles; Rats; Rats, Zucker; Stroke	2011
Atorvastatin decreases computed tomography and S100-assessed brain ischemia after subarachnoid aneurysmal hemorrhage: a comparative study. Critical care medicine, 2012, Volume: 40, Issue:2 Topics: Adult; Aged; Atorvastatin; Biomarkers; Brain Ischemia; Case-Control Studies; Confidence Intervals; Critical Care; Critical Illness; Female; Follow-Up Studies; Glasgow Coma Scale; Heptanoic Acids; Hospitals, University; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intensive Care Units; Male; Middle Aged; Nerve Growth Factors; Predictive Value of Tests; Pyrroles; Retrospective Studies; Risk Assessment; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Severity of Illness Index; Statistics, Nonparametric; Subarachnoid Hemorrhage; Survival Rate; Tomography, X-Ray Computed; Treatment Outcome; Vasospasm, Intracranial	2012
Statins as neuroprotectants after subarachnoid hemorrhage. Critical care medicine, 2012, Volume: 40, Issue:2 Topics: Atorvastatin; Brain Ischemia; Female; Heptanoic Acids; Humans; Male; Nerve Growth Factors; Pyrroles; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Subarachnoid Hemorrhage	2012
Synthesis and biological evaluation of (--)-linarinic acid derivatives as neuroprotective agents against OGD-induced cell damage. Archiv der Pharmazie, 2012, Volume: 345, Issue:6 Topics: Brain Ischemia; Cell Culture Techniques; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Culture Media; Dose-Response Relationship, Drug; Glucose; Humans; Models, Biological; Molecular Structure; Neurons; Neuroprotective Agents; Oxygen; Pyrroles; Quinazolines; Reperfusion Injury; Stereoisomerism; Structure-Activity Relationship	2012
Capsular warning syndrome caused by spontaneous middle cerebral artery dissection. CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:8 Topics: Angiography, Digital Subtraction; Aspirin; Atorvastatin; Brain Ischemia; Cerebral Angiography; Diffusion Magnetic Resonance Imaging; Echocardiography; Electrocardiography; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Image Processing, Computer-Assisted; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Middle Aged; Middle Cerebral Artery; Platelet Aggregation Inhibitors; Pyrroles; Smoking	2012
Atorvastatin and whisker stimulation synergistically enhance angiogenesis in the barrel cortex of rats following focal ischemia. Neuroscience letters, 2012, Sep-13, Volume: 525, Issue:2 Topics: Animals; Atorvastatin; Brain Ischemia; Brain-Derived Neurotrophic Factor; Fluorescent Antibody Technique; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Microvessels; Neovascularization, Physiologic; Pyrroles; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Vascular Endothelial Growth Factor A; Vibrissae	2012
An L-type calcium channel agonist, bay K8644, extends the window of intervention against ischemic neuronal injury. Molecular neurobiology, 2013, Volume: 47, Issue:1 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain Ischemia; Butadienes; Calcium Channels, L-Type; Extracellular Signal-Regulated MAP Kinases; Maze Learning; Memory; Neurons; Neuroprotective Agents; Nitriles; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar	2013
Grey matter and white matter ischemic damage is reduced by the competitive AMPA receptor antagonist, SPD 502. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2002, Volume: 22, Issue:9 Topics: Aldehydes; Animals; Brain Ischemia; Carotid Artery, External; Carotid Artery, Internal; Disease Models, Animal; Functional Laterality; Growth Inhibitors; Humans; Isoquinolines; Male; Oligodendroglia; Periaqueductal Gray; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tetrahydroisoquinolines	2002
Withdrawal of statin treatment abrogates stroke protection in mice. Stroke, 2003, Volume: 34, Issue:2 Topics: Animals; Aorta; Atorvastatin; Bleeding Time; Blood Coagulation; Brain; Brain Ischemia; Disease Models, Animal; Drug Administration Schedule; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ligation; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Platelet Activation; Pyrroles; rhoA GTP-Binding Protein; RNA, Messenger; Stroke; Substance Withdrawal Syndrome; Vena Cava, Inferior; Venous Thrombosis	2003
Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2005, Volume: 25, Issue:6 Topics: Animals; Atorvastatin; Brain Ischemia; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracranial Embolism; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pyrroles; Simvastatin; Stroke; Tissue Plasminogen Activator	2005
Long-term protective effect of atorvastatin in permanent focal cerebral ischemia. Brain research, 2005, Aug-09, Volume: 1052, Issue:2 Topics: Animals; Atorvastatin; Behavior, Animal; Blood Circulation; Brain Infarction; Brain Ischemia; Dizocilpine Maleate; Heptanoic Acids; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Male; Motor Activity; Neuroprotective Agents; Psychomotor Performance; Pyrroles; Rats; Rats, Long-Evans; Recovery of Function; Staining and Labeling; Time; Time Factors	2005
Atorvastatin downregulates tissue plasminogen activator-aggravated genes mediating coagulation and vascular permeability in single cerebral endothelial cells captured by laser microdissection. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2006, Volume: 26, Issue:6 Topics: Animals; Anticholesteremic Agents; Atorvastatin; Blood Coagulation; Brain; Brain Ischemia; Capillary Permeability; Down-Regulation; Endothelial Cells; Gene Expression; Heptanoic Acids; Humans; Lasers; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Microdissection; Pyrroles; Rats; Rats, Wistar; Receptor, PAR-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thromboplastin; Tissue Plasminogen Activator	2006
A synthetic NCAM-derived peptide, FGL, protects hippocampal neurons from ischemic insult both in vitro and in vivo. The European journal of neuroscience, 2005, Volume: 22, Issue:7 Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Count; Cells, Cultured; Drug Interactions; Glucose; Hippocampus; Hypoxia; Neural Cell Adhesion Molecules; Neurons; Neuroprotective Agents; Organ Culture Techniques; Phosphorylation; Propidium; Pyridinium Compounds; Pyrroles; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Fibroblast Growth Factor; Synapses; Tetrazolium Salts; Thiazoles; Time Factors	2005
MRI of combination treatment of embolic stroke in rat with rtPA and atorvastatin. Journal of the neurological sciences, 2006, Jul-15, Volume: 246, Issue:1-2 Topics: Animals; Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Cerebrovascular Circulation; Data Interpretation, Statistical; Heptanoic Acids; Intracranial Embolism; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Microcirculation; Microscopy, Fluorescence; Plasminogen Activators; Pyrroles; Rats; Rats, Wistar; Recombinant Proteins; Stroke	2006
[Effect of atorvastatin on Fas (CD95/Apo-1) expression in normal or ischemic brain]. Anales de medicina interna (Madrid, Spain : 1984), 2006, Volume: 23, Issue:4 Topics: Animals; Apoptosis; Atorvastatin; Brain Ischemia; fas Receptor; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Neuroprotective Agents; Pyrroles; Rats; Rats, Sprague-Dawley	2006
Statins and cerebral vasomotor reactivity: implications for a new therapy? Stroke, 2006, Volume: 37, Issue:10 Topics: Adult; Animals; Arginine; Atorvastatin; Brain Ischemia; Cerebrovascular Circulation; Clinical Trials, Phase II as Topic; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Intracranial Aneurysm; Mice; Middle Cerebral Artery; Nitric Oxide; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Research Design; Risk Factors; Simvastatin; Stroke; Subarachnoid Hemorrhage; Ultrasonography, Doppler, Transcranial; Vasodilation; Vasomotor System; Vasospasm, Intracranial	2006
Protein kinase C inhibition attenuates vascular ETB receptor upregulation and decreases brain damage after cerebral ischemia in rat. BMC neuroscience, 2007, Jan-09, Volume: 8 Topics: Animals; Atrophy; Brain; Brain Ischemia; Cerebrovascular Circulation; Indoles; Male; Middle Cerebral Artery; Protein Kinase C; Pyrroles; Rats; Rats, Wistar; Receptor, Endothelin B; Up-Regulation	2007
Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Experimental neurology, 2007, Volume: 206, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Atorvastatin; Brain Edema; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Chemotaxis, Leukocyte; Cognition Disorders; Cytokines; Disease Models, Animal; Encephalitis; Endothelial Cells; Heptanoic Acids; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Pyrroles; Recovery of Function; RNA, Messenger; Simvastatin; Treatment Outcome	2007
[The 2006 American Heart Association selection of the "top ten advances in heart disease and stroke research"]. Revue medicale de Liege, 2007, Volume: 62, Issue:4 Topics: Abnormalities, Drug-Induced; Adolescent; Adult; American Heart Association; Anti-Inflammatory Agents; Anticholesteremic Agents; Atherosclerosis; Atorvastatin; Brain Ischemia; Child; Coronary Disease; Heart Diseases; Heart Valve Prosthesis; Heart-Assist Devices; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Attack, Transient; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Obesity; Peptidyl-Dipeptidase A; Process Assessment, Health Care; Pyrroles; Stroke; Tissue Engineering; United States	2007
Discontinuation of statin therapy and clinical outcome after ischemic stroke. Stroke, 2007, Volume: 38, Issue:10 Topics: Aged; Atorvastatin; Brain Ischemia; Female; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Pyrroles; Simvastatin; Stroke; Substance Withdrawal Syndrome	2007
K+ channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein, and amyloid beta-protein precursor genes and neuronal death in rat hippocampus. Proceedings of the National Academy of Sciences of the United States of America, 1993, Oct-15, Volume: 90, Issue:20 Topics: Alternative Splicing; Amyloid beta-Protein Precursor; Animals; Base Sequence; Benzopyrans; Brain Ischemia; Cell Death; Cromakalim; Gene Expression Regulation; Guanidines; Heat-Shock Proteins; Hippocampus; In Situ Hybridization; Male; Molecular Sequence Data; Neurons; Niacinamide; Nicorandil; Oligonucleotide Probes; Pinacidil; Potassium Channels; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyrroles; Rats; Rats, Wistar; RNA, Messenger	1993
Effect of KBT-3022, a new cyclooxygenase inhibitor, on experimental brain edema in vitro and in vivo. European journal of pharmacology, 1996, Feb-22, Volume: 297, Issue:3 Topics: Animals; Arachidonic Acid; Aspirin; Brain; Brain Edema; Brain Ischemia; Cyclooxygenase Inhibitors; Gerbillinae; Guinea Pigs; In Vitro Techniques; Indomethacin; Lipid Peroxidation; Male; Pyrroles; Thiazoles	1996
Protective effect of KBT-3022, a new cyclooxygenase inhibitor, in cerebral hypoxia and ischemia. Japanese journal of pharmacology, 1995, Volume: 69, Issue:4 Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hippocampus; Hypoxia; Male; Mice; Pyrroles; Thiazoles	1995
Neuroprotective efficacy and mechanisms of novel pyrrolopyrimidine lipid peroxidation inhibitors in the gerbil forebrain ischemia model. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1998, Volume: 18, Issue:5 Topics: Animals; Brain Ischemia; Cell Death; Gerbillinae; Immunohistochemistry; Lipid Metabolism; Lipid Peroxidation; Male; Prosencephalon; Pyrimidines; Pyrroles	1998
Effects of GR-89696 and the novel peripherally selective OP2 agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat. Methods and findings in experimental and clinical pharmacology, 1999, Volume: 21, Issue:2 Topics: Animals; Binding, Competitive; Brain Edema; Brain Ischemia; Cerebral Arteries; Levodopa; Ligation; Male; Neuroprotective Agents; Piperazines; Pyrroles; Pyrrolidines; Rabbits; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, Opioid, kappa	1999
Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice. Stroke, 2000, Volume: 31, Issue:10 Topics: Animals; Aorta; Atorvastatin; beta-Thromboglobulin; Blood Coagulation; Blood Platelets; Brain Ischemia; Cholesterol; Dose-Response Relationship, Drug; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infarction, Middle Cerebral Artery; Mice; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Platelet Activation; Platelet Factor 4; Pyrroles; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; rho GTP-Binding Proteins; RNA, Messenger; Up-Regulation	2000
Staurosporine, a novel protein kinase C inhibitor, prevents postischemic neuronal damage in the gerbil and rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1990, Volume: 10, Issue:5 Topics: Alkaloids; Animals; Brain Ischemia; Carbazoles; Cell Survival; Gerbillinae; Hippocampus; Indoles; Male; Neurons; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Inbred WF; Staurosporine; Sulfonamides	1990