pyrroles has been researched along with Bone Loss, Osteoclastic in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 9 (42.86) | 29.6817 |
| 2010's | 7 (33.33) | 24.3611 |
| 2020's | 4 (19.05) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Z; Fang, J; Gao, J; He, D; Lai, H; Liu, S; Lou, C; Ni, K; Pan, B; Pan, W; Ye, L; Zhang, Y; Zheng, L | 1 |
| Chen, D; Chen, K; Chen, P; Davis, RA; Jin, H; Kuek, V; Liu, Q; Qiu, H; Song, D; Song, F; Wang, C; Wang, Q; Xu, J; Xu, K; Ye, Z; Zhao, J | 1 |
| Lu, X; Luo, S; Pang, C; Qin, H; Wen, L; Zhu, B | 1 |
| Canhão, H; Cascão, R; da Glória, VG; Finnilä, MAJ; Fonseca, JE; Lopes, IP; Saarakkala, S; Vidal, B; Zioupos, P | 1 |
| Du, GH; Jian, LL; Li, CH; Liu, XY; Sun, L; Xu, LL; Yu, RH; Zhao, JX | 1 |
| Hayashi, M; Kim, Y; Nakashima, T; Ono, T; Takayanagi, H; Yoda, T | 1 |
| Ge, XT; Guo, JX; Li, CL; Li, TY; Lv, F; Wang, XF; Wang, YJ | 1 |
| Akiyama, Y; Araki, Y; Kayama, H; Kitaura, H; Mimura, T; Miyazaki, T; Miyoshi, F; Sato, K; Takeda, K; Yokota, K | 1 |
| Choi, SW; Heo, JC; Kim, KJ; Kim, SH; Lee, H; Lee, MS; Lee, SY; Moon, SH; Park, SJ; Ryu, BJ; Yeon, JT | 1 |
| Ehara, T; Fukaya, H; Hitomi, Y; Irie, O; Iwasaki, G; Kometani, M; Kosaka, T; Masuya, K; Matsuura, N; Miyake, T; Nonomura, K; Sugiyama, I; Teno, N; Toriyama, K; Uchiyama, N; Umemura, I | 1 |
| Masuya, K; Teno, N | 1 |
| Bailey, SA; Bansal, PN; Bollinger, CS; Bonar, SL; Guzova, JA; Happa, FA; Head, RD; Hegen, M; Jesson, MI; Kishore, N; LaBranche, TP; Mbalaviele, G; Meyer, DM; Radi, ZA; Stewart, ZS; Storer, CE; Symanowicz, PT; Thompson, JM; Wellen, JW; Wilkie, DP; Zhan, Y | 1 |
| Kawashima, H; Nagai, K; Nishikawa, A; Ochi, T; Ohkuma, S; Sato, T; Tanaka, Y; Tanigaki, K | 1 |
| Asai, T; Iguchi, A; Kanda, S; Koike, T; Kuzuya, M; Nakamura, A; Satake, S; Suzuki, Y; Umegaki, H | 1 |
| Fabbro, D; Funari, A; Kneissel, M; Longo, M; Migliaccio, S; Recchia, I; Rucci, N; Susa, M; Taranta, A; Teti, A | 1 |
| Boileau, C; Boily, M; Brunet, J; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Pelletier, JP; Reboul, P | 1 |
| Kang, SK; Kim, CH; Kim, YH; Park, YG | 1 |
| Feyen, J; Glatt, M; Green, J; Jeschke, M; Missbach, M; Müller, K; Susa, M | 1 |
| Farnier, M; Mercuri, M; Stein, EA; Waldstreicher, J | 1 |
| Nagy, Z; Radeff, JM; Stern, PH | 1 |
| Conradie, MM; Gopal, R; Hough, S; Hulley, PA; Maritz, FJ | 1 |
1 review(s) available for pyrroles and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Orally bioavailable cathepsin K inhibitors with pyrrolopyrimidine scaffold.
Topics: Administration, Oral; Animals; Biological Availability; Bone Resorption; Cathepsin K; Cysteine Proteinase Inhibitors; Humans; Osteoporosis; Pyrimidines; Pyrroles; Structure-Activity Relationship | 2010 |
1 trial(s) available for pyrroles and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Effects of statins on biomarkers of bone metabolism: a randomised trial.
Topics: Adult; Aged; Alkaline Phosphatase; Anticholesteremic Agents; Atorvastatin; Biomarkers; Bone and Bones; Bone Development; Bone Resorption; Collagen; Collagen Type I; Dose-Response Relationship, Drug; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Male; Middle Aged; Peptides; Pyrroles; Simvastatin | 2001 |
19 other study(ies) available for pyrroles and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
SIS3 suppresses osteoclastogenesis and ameliorates bone loss in ovariectomized mice by modulating Nox4-dependent reactive oxygen species.
Topics: Animals; Blotting, Western; Bone Resorption; Cell Survival; Cells, Cultured; Female; Gene Expression Regulation; Isoquinolines; Mice, Inbred C57BL; Microscopy, Confocal; NADPH Oxidase 4; Osteoblasts; Osteoclasts; Osteogenesis; Ovariectomy; Pyridines; Pyrroles; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction | 2022 |
Hymenialdisine: A Marine Natural Product That Acts on Both Osteoblasts and Osteoclasts and Prevents Estrogen-Dependent Bone Loss in Mice.
Topics: Animals; Azepines; Biological Products; Bone Resorption; Cell Differentiation; Estrogens; Female; Glycogen Synthase Kinase 3; Mice; Mice, Inbred C57BL; NF-kappa B; NFATC Transcription Factors; Osteoblasts; Osteoclasts; Osteogenesis; Osteolysis; Pyrroles; RANK Ligand | 2020 |
Sotrastaurin, a PKC inhibitor, attenuates RANKL-induced bone resorption and attenuates osteochondral pathologies associated with the development of OA.
Topics: Animals; Bone and Bones; Bone Resorption; Cartilage Diseases; Cartilage, Articular; Cattle; Cell Differentiation; Female; Male; Mice; Mice, Inbred C57BL; Osteoarthritis; Osteoclasts; Protein Kinase C; Pyrroles; Quinazolines; RANK Ligand; Signal Transduction | 2020 |
Effects of tofacitinib in early arthritis-induced bone loss in an adjuvant-induced arthritis rat model.
Topics: Adjuvants, Immunologic; Animals; Arthritis; Bone and Bones; Bone Remodeling; Bone Resorption; Disease Models, Animal; Female; Osteocalcin; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Treatment Outcome; X-Ray Microtomography | 2018 |
Stattic inhibits RANKL-mediated osteoclastogenesis by suppressing activation of STAT3 and NF-κB pathways.
Topics: Animals; Arthritis, Rheumatoid; Bone Resorption; Cyclic S-Oxides; Gene Expression Regulation; Genes, fos; Humans; Janus Kinases; Macrophages; Mice; NF-kappa B; NFATC Transcription Factors; Osteogenesis; Piperidines; Pyrimidines; Pyrroles; RANK Ligand; RAW 264.7 Cells; Signal Transduction; STAT3 Transcription Factor | 2018 |
Suppression of hematopoietic cell kinase ameliorates the bone destruction associated with inflammation.
Topics: Animals; Blotting, Western; Bone Resorption; Cell Differentiation; Cells, Cultured; Gene Expression Regulation; Inflammation; Mice; Mice, Inbred BALB C; Osteoclasts; Osteogenesis; Proto-Oncogene Proteins c-hck; Pyrimidines; Pyrroles; RNA; src-Family Kinases | 2020 |
Colony-stimulating factor 1 receptor inhibition prevents against lipopolysaccharide -induced osteoporosis by inhibiting osteoclast formation.
Topics: Aminopyridines; Animals; Biomechanical Phenomena; Bone Density; Bone Resorption; Cancellous Bone; Disease Models, Animal; Lipopolysaccharides; Male; Osteoclasts; Osteoporosis; Pyrroles; Rats, Sprague-Dawley; Receptor, Macrophage Colony-Stimulating Factor; Tibia | 2019 |
Combination of tumor necrosis factor α and interleukin-6 induces mouse osteoclast-like cells with bone resorption activity both in vitro and in vivo.
Topics: Animals; Bone Resorption; Cell Differentiation; Cells, Cultured; Interleukin-6; Macrophages; Mice; NF-kappa B; NFATC Transcription Factors; Osteoclasts; Osteoprotegerin; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Pyrimidines; Pyrroles; RANK Ligand; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2014 |
Repositioning Potential of PAK4 to Osteoclastic Bone Resorption.
Topics: Animals; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Disease Models, Animal; Humans; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Osteoclasts; p21-Activated Kinases; Pyrazoles; Pyrroles | 2015 |
Effect of cathepsin K inhibitors on bone resorption.
Topics: Animals; Bone Marrow; Bone Resorption; Cathepsin K; Cathepsins; Collagen Type I; Cysteine Proteinase Inhibitors; Haplorhini; Pyrimidines; Pyrroles; Rats; Spiro Compounds; Tissue Distribution | 2008 |
JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production.
Topics: Animals; Arthritis, Experimental; Bone Resorption; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Female; Humans; Janus Kinases; Macrophages; Monocytes; Osteoclasts; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; RANK Ligand; Rats; Rats, Inbred Lew; Signal Transduction; T-Lymphocytes | 2012 |
BE-18591 as a new H(+)/Cl(-) symport ionophore that inhibits immunoproliferation and gastritis.
Topics: Adenosine Triphosphatases; Animals; Antiporters; Bone Resorption; Cell Division; CHO Cells; Cricetinae; Gastric Acid; Gastritis; Guinea Pigs; Male; PC12 Cells; Pyrroles; Rats; Rats, Wistar; Spleen | 2002 |
Atorvastatin, 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, reduces bone resorption in the elderly.
Topics: Aged; Aged, 80 and over; Alkaline Phosphatase; Atorvastatin; Biomarkers; Bone Density; Bone Resorption; Case-Control Studies; Collagen; Collagen Type I; Creatinine; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Peptides; Prospective Studies; Pyrroles; Treatment Outcome | 2003 |
Reduction of c-Src activity by substituted 5,7-diphenyl-pyrrolo[2,3-d]-pyrimidines induces osteoclast apoptosis in vivo and in vitro. Involvement of ERK1/2 pathway.
Topics: Actins; Adenocarcinoma, Clear Cell; Animals; Apoptosis; Bone Resorption; Caspases; Cell Adhesion; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Female; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Osteoclasts; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Pyrroles; Rats; Rats, Wistar | 2004 |
The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.
Topics: Acetates; Animals; Bone Resorption; Cathepsin K; Cathepsins; Collagenases; Dogs; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Pyrroles | 2004 |
cAMP-PKA signaling pathway regulates bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts.
Topics: Animals; Antibodies; Bone Resorption; Carbazoles; Cathepsin K; Cathepsins; Cells, Cultured; Chloroquine; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Indoles; Isoquinolines; Lysosomes; Mannose; Mice; Monensin; Naphthalenes; Osteoclasts; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Pyrroles; Receptor, IGF Type 2; Signal Transduction; Sulfonamides | 2006 |
A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo.
Topics: 3T3 Cells; Animals; Bone Diseases, Metabolic; Bone Resorption; Cell Adhesion Molecules; Cell Survival; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Disease Models, Animal; Enzyme Inhibitors; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Male; Mice; Oncogene Protein pp60(v-src); Osteoblasts; Ovariectomy; Paxillin; Phosphoproteins; Phosphorylation; Pregnancy; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; src-Family Kinases | 1999 |
Involvement of PKC-beta in PTH, TNF-alpha, and IL-1 beta effects on IL-6 promoter in osteoblastic cells and on PTH-stimulated bone resorption.
Topics: Animals; Bone Resorption; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Interleukin-1; Interleukin-6; Isoenzymes; Mesylates; Osteoblasts; Parathyroid Hormone; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C beta; Protein Transport; Pyrroles; Rats; Tumor Necrosis Factor-alpha | 2001 |
Effect of statins on bone mineral density and bone histomorphometry in rodents.
Topics: Animals; Atorvastatin; Bone Density; Bone Development; Bone Resorption; Dose-Response Relationship, Drug; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ovariectomy; Pravastatin; Pyrroles; Radiography; Rats; Rats, Sprague-Dawley; Simvastatin | 2001 |