pyrroles has been researched along with B-Cell Chronic Lymphocytic Leukemia in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (39.39) | 29.6817 |
| 2010's | 19 (57.58) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Ashelford, K; Corcoran, DB; Fegan, CD; Giles, PJ; Lewis, T; Miraz Rahman, K; Pepper, AGS; Pepper, C; Thurston, DE; Walsby, EJ | 1 |
| Alinari, L; Baiocchi, RA; Baskin, E; Beaver, L; Blachly, JS; Bollag, G; Brinton, L; Byrd, JC; Cannon, M; Carias, H; Dong, K; El-Gamal, D; Ewing, T; Goettl, VM; Grieselhuber, NR; Habets, G; Harrington, B; Hing, ZA; Ibrahim, P; Lai, TH; Lapalombella, R; Lehman, AM; Lucas, DM; Ma, Y; Marimuthu, A; Mathé, EA; Matusow, B; Mitchell, S; Nespi, M; Ozer, HG; Powell, B; Rezaei, H; Sampath, D; Sanftner, L; Severson, P; Shellooe, R; Shi, S; Spevak, W; Tantoy, C; Tsang, G; Walters, J; Williams, K; Woyach, JA; Yu, L; Zhang, C; Zhang, J; Zhang, Y | 1 |
| Borowiak, A; Błoński, JZ; Cebula-Obrzut, B; Hikisz, P; Kiliańska, ZM; Robak, T; Smolewski, P; Żołnierczyk, JD | 1 |
| Bolaman, Z; Kadikoylu, G; Karul, A; Sargin, G; Yavasoglu, I | 1 |
| Abesada, G; Belgnaoui, SM; Beljanski, V; Ben Yebdri, F; Brown, D; Goulet, ML; Haddad, EK; He, Z; Hiscott, J; Nichols, C; Richards, S; Samuel, S; Shamy, A; Steel, C; Van Grevenynghe, J | 1 |
| Andritsos, L; Awan, FT; Blachly, JS; Byrd, JC; Cannon, M; Chen, CS; El-Gamal, D; Jones, J; LaFollette, TD; Lapalombella, R; Lehman, A; Maddocks, K; Williams, E; Williams, K; Woyach, JA; Wu, CH; Zhang, X; Zhong, Y | 1 |
| Anderson, MA; Huang, D; Roberts, A | 1 |
| Cheng, S; Coleman, M; Guo, A; Lu, P; Ma, J; Wang, YL | 1 |
| Di Stefano, C; Maffei, G; Mirone, G; Perna, S | 1 |
| Brown, JR; Fisher, DC; Freedman, AS; Mikler, E; Neuberg, D; Reynolds, HM; Takebe, N; Tesar, B; Thompson, C; Werner, L; Yu, L | 1 |
| Andrews, DW; Brauer, PM; Hariharan, S; Leber, B; Oakes, CC; Oppermann, S; Shi, Y; Spaner, DE; Ylanko, J; Zúñiga-Pflücker, JC | 1 |
| Davids, MS; Lampson, BL | 1 |
| Campo, E; Colomer, D; López-Guerra, M; Montserrat, E; Nguyen, M; Pérez-Galán, P; Roué, G; Shore, GC; Villamor, N | 1 |
| Cheson, BD; Claxton, DF; Crump, M; Faderl, S; Keating, MJ; Kipps, T; O'Brien, SM; Viallet, J | 1 |
| Lin, TS | 1 |
| Chandra, J; Keating, MJ; Miller, CP; Palladino, M; Rudra, S; Wierda, WG | 1 |
| Browne, PV; Butini, S; Campiani, G; Catherwood, MA; Greene, LM; Hayat, A; Lawler, M; Maginn, EN; McElligott, AM; McGuckin, S; Vandenberghe, E; Williams, DC; Zisterer, DM | 1 |
| Abrams, ST; Brown, BR; Slupsky, JR; Zuzel, M | 1 |
| Cwynarski, K; Hart, SM; Hoffbrand, AV; Lowdell, MW; Prentice, AG; Samuel, ER; Steele, AJ; Wickremasinghe, RG | 1 |
| Bell, J; Hiscott, J; Nguyên, TL; Oliere, S; Samuel, S; Shamy, A; Tumilasci, VF | 1 |
| Bowen, D; Byrd, J; Call, T; Erlichman, C; Ghosh, A; Hanson, C; Jelinek, D; Kay, N; Laplant, B; Laumann, K; Shanafelt, T; Villalona-Calero, M; Wu, W; Zent, C | 1 |
| Chu, DT | 1 |
| Catherwood, MA; Kliszczak, AE; Montagnoli, A; Murillo, LS; Natoni, A; O'Dwyer, M; Samali, A; Santocanale, C | 1 |
| Coll-Mulet, L; Cosialls, AM; de Frias, M; de la Banda, E; de Sevilla, AF; Gil, J; González-Gironès, DM; Iglesias-Serret, D; Pérez-Perarnau, A; Pons, G; Rubio-Patiño, C | 1 |
| Billard, C | 1 |
| Delavault, P; Fegan, CD; Hambly, RM; Pepper, CJ; Thurston, DE | 1 |
| Balakrishnan, K; Gandhi, V; Keating, MJ; Nimmanapalli, R; Ravandi, F | 1 |
| Chandra, J; Keating, M; Krupnik, Y; McConkey, D; Palladino, M; Ruiz, S | 1 |
| Abrams, ST; Farahani, M; Hughes, M; Jones, GM; Lakum, T; Lin, K; Slupsky, JR; Treweeke, AT; Zuzel, M | 1 |
| Barragán, M; Campàs, C; Coll-Mulet, L; Cosialls, AM; de Frias, M; Domingo, A; Gil, J; Iglesias-Serret, D; Pons, G; Santidrián, AF | 1 |
| Bargetzi, M; Puric, E; Schönenberger, A; Sendi, P | 1 |
| Delavault, P; Fegan, C; Hartley, JA; Lowe, H; Pepper, C; Thurieau, C; Thurston, DE | 1 |
| Grosicka, A; Grosicki, S; Hołowiecki, J | 1 |
5 review(s) available for pyrroles and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Targeting BCL2 for the treatment of lymphoid malignancies.
Topics: Aniline Compounds; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Gossypol; Hematologic Neoplasms; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2014 |
The Development and Current Use of BCL-2 Inhibitors for the Treatment of Chronic Lymphocytic Leukemia.
Topics: Aniline Compounds; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Gossypol; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Neutropenia; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Thionucleotides | 2017 |
Novel agents in chronic lymphocytic leukemia: efficacy and tolerability of new therapies.
Topics: Antineoplastic Agents; Bendamustine Hydrochloride; Flavonoids; Humans; Indoles; Lenalidomide; Leukemia, Lymphocytic, Chronic, B-Cell; Maximum Tolerated Dose; Nitrogen Mustard Compounds; Piperidines; Pyrroles; Thalidomide; Thionucleotides; Treatment Outcome | 2008 |
[Clinical manifestation of targeted drugs in individualized therapy of malignant tumors].
Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cyclophosphamide; Doxorubicin; Drug Delivery Systems; ErbB Receptors; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid; Lymphoma, Large B-Cell, Diffuse; Mutation; Neoplasms; Piperazines; Prednisone; Pyrimidines; Pyrroles; Remission Induction; Rituximab; Sunitinib; Vincristine | 2010 |
[Clinical importance of angiogenesis and angiogenic factors in oncohematology].
Topics: Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Angiopoietin-1; Angiopoietin-2; Hematologic Neoplasms; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasm Metastasis; Neovascularization, Pathologic; Oxindoles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Propionates; Pyrroles; Receptor, TIE-2; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factors | 2007 |
3 trial(s) available for pyrroles and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Obatoclax in combination with fludarabine and rituximab is well-tolerated and shows promising clinical activity in relapsed chronic lymphocytic leukemia.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Chromosome Aberrations; Combined Modality Therapy; Disease Progression; Female; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Mutation; Neoplasm Staging; Pyrroles; Recurrence; Retreatment; Rituximab; Treatment Outcome; Vidarabine | 2015 |
Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia.
Topics: Aged; Anemia; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Female; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocyte Count; Male; Maximum Tolerated Dose; Middle Aged; Platelet Count; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Thrombocytosis | 2009 |
Phase II trials of single-agent anti-VEGF therapy for patients with chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Female; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Pyrroles; Quinazolines; Sunitinib; Treatment Outcome; Vascular Endothelial Growth Factor A | 2010 |
25 other study(ies) available for pyrroles and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers.
Topics: Adenine; Animals; Apoptosis; Benzodiazepines; Bortezomib; Hematologic Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Mice, Inbred NOD; Mice, SCID; NF-kappa B; Piperidines; Pyrroles; Tumor Microenvironment | 2021 |
BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor.
Topics: Animals; Antineoplastic Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Humans; Isoxazoles; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Mice, SCID; Nuclear Proteins; Pyridines; Pyrroles; Signal Transduction; Transcription Factors; Xenograft Model Antitumor Assays | 2018 |
Promising anti-leukemic activity of atorvastatin.
Topics: Aged; Aged, 80 and over; Apoptosis; Apoptosis Regulatory Proteins; Atorvastatin; bcl-2-Associated X Protein; Cell Membrane Permeability; Cell Survival; Cyclin-Dependent Kinase Inhibitor p27; DNA Fragmentation; Female; Heptanoic Acids; Humans; Lamin B Receptor; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Male; Middle Aged; Mitochondria; Mitochondrial Membranes; Myeloid Cell Leukemia Sequence 1 Protein; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Receptors, Cytoplasmic and Nuclear | 2013 |
The activity of atorvastatin and rosiglitazone on CD38, ZAP70 and apoptosis in lymphocytes of B-cell chronic lymphocytic leukemia in vitro.
Topics: ADP-ribosyl Cyclase 1; Annexin A5; Apoptosis; Atorvastatin; Calcium; CD5 Antigens; Female; Heptanoic Acids; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Lymphocytes; Male; Middle Aged; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Rosiglitazone; Thiazolidinediones; ZAP-70 Protein-Tyrosine Kinase | 2013 |
BCL-2 inhibitors sensitize therapy-resistant chronic lymphocytic leukemia cells to VSV oncolysis.
Topics: Animals; Biphenyl Compounds; Blotting, Western; Cell Line, Tumor; Cell Survival; Cells, Cultured; Flow Cytometry; Fluorescent Antibody Technique; Humans; Immunoprecipitation; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Nitrophenols; Oncolytic Viruses; Piperazines; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Vesicular stomatitis Indiana virus | 2013 |
PKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL.
Topics: Apoptosis; beta Catenin; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Protein Kinase C beta; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Receptors, Antigen, B-Cell; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Microenvironment; Wnt Signaling Pathway | 2014 |
Functional characterization of BTK(C481S) mutation that confers ibrutinib resistance: exploration of alternative kinase inhibitors.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Agents; B-Lymphocytes; Cell Line, Tumor; Cyclohexylamines; Dasatinib; Drug Resistance, Neoplasm; Female; Gene Expression; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged; Mutation; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrroles; RNA, Small Interfering; Signal Transduction; Structure-Activity Relationship; Thiazoles | 2015 |
The effects of pyrrolo[1,2-b][1,2,5]benzothiadiazepines in MEC1 cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; bcl-2-Associated X Protein; Beclin-1; Benzodiazepines; Blotting, Western; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Survival; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Membrane Proteins; Microtubule-Associated Proteins; Molecular Structure; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Signal Transduction; Thiazepines | 2015 |
High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells.
Topics: Adenine; bcl-X Protein; Bridged Bicyclo Compounds, Heterocyclic; Cellular Microenvironment; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Humans; Imaging, Three-Dimensional; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Mutation; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyrimidines; Pyrroles; Quinazolinones; Reproducibility of Results; Signal Transduction; Stromal Cells; Sulfonamides; Sunitinib; Up-Regulation | 2016 |
BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Drug Synergism; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Mantle-Cell; Mitochondria; Phosphorylation; Protease Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyrroles; Tumor Cells, Cultured | 2008 |
Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells.
Topics: Acetylation; Antioxidants; Apoptosis; Boronic Acids; Bortezomib; Caspase 8; Drug Synergism; Drug Therapy, Combination; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Immunoblotting; Immunoprecipitation; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Oxidative Stress; Protease Inhibitors; Proteasome Inhibitors; Protein Processing, Post-Translational; Pyrazines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxides; Tumor Cells, Cultured; Vorinostat | 2009 |
The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Caspase 8; DNA (Cytosine-5-)-Methyltransferases; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunoblotting; Immunoglobulin Heavy Chains; JNK Mitogen-Activated Protein Kinases; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Microtubules; Middle Aged; Oxazepines; Prognosis; Pyrroles; Tubulin; Vidarabine; ZAP-70 Protein-Tyrosine Kinase | 2009 |
Vascular endothelial growth factor stimulates protein kinase CbetaII expression in chronic lymphocytic leukemia cells.
Topics: Agammaglobulinaemia Tyrosine Kinase; Base Sequence; DNA Primers; Enzyme Activation; Gene Expression; Humans; In Vitro Techniques; Leukemia, Lymphocytic, Chronic, B-Cell; Mesylates; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Recombinant Proteins; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Vascular Endothelial Growth Factor A | 2010 |
The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment.
Topics: Apoptosis; bcl-X Protein; Bone Marrow Cells; Calcium-Calmodulin-Dependent Protein Kinases; Cytochromes c; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation, Leukemic; Humans; Interleukin-4; Janus Kinase 3; Leukemia, Lymphocytic, Chronic, B-Cell; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Pyrroles; STAT6 Transcription Factor; Stromal Cells; T-Lymphocytes; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2010 |
VSV oncolysis in combination with the BCL-2 inhibitor obatoclax overcomes apoptosis resistance in chronic lymphocytic leukemia.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; Female; Genetic Therapy; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Mice, SCID; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; Vesiculovirus | 2010 |
Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspases; CD40 Ligand; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Cyclin-Dependent Kinase 9; DNA Replication; Gene Expression Regulation, Leukemic; Humans; Interleukin-4; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Myeloid Cell Leukemia Sequence 1 Protein; NIH 3T3 Cells; Phosphorylation; Piperidones; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Pyrroles; RNA Polymerase II; Signal Transduction | 2011 |
Analysis of apoptosis regulatory genes altered by histone deacetylase inhibitors in chronic lymphocytic leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Leukemia, Lymphocytic, Chronic, B-Cell; Pyrroles; RNA, Messenger; Tumor Cells, Cultured; Vorinostat | 2011 |
Development of Noxa-like BH3 mimetics for apoptosis-based therapeutic strategy in chronic lymphocytic leukemia.
Topics: Aniline Compounds; Apoptosis; Biomimetic Materials; Gossypol; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Myeloid Cell Leukemia Sequence 1 Protein; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2012 |
The novel sequence-specific DNA cross-linking agent SJG-136 (NSC 694501) has potent and selective in vitro cytotoxicity in human B-cell chronic lymphocytic leukemia cells with evidence of a p53-independent mechanism of cell kill.
Topics: Apoptosis; B-Lymphocytes; Benzodiazepines; Benzodiazepinones; Case-Control Studies; Caspase 3; Caspases; Cross-Linking Reagents; DNA Damage; DNA Repair; Enzyme Activation; Humans; K562 Cells; Leukemia, Lymphocytic, Chronic, B-Cell; Pyrroles; T-Lymphocytes; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vidarabine | 2004 |
Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; B-Lymphocytes; Caspases; DNA Damage; Enzyme Inhibitors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Mitochondria; Phosphorylation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; T-Lymphocytes; Tumor Suppressor Protein p53 | 2006 |
The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia.
Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Humans; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; Pyrroles | 2006 |
B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CbetaII.
Topics: Bryostatins; Calcium; Cell Survival; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Macrolides; Mesylates; Protein Kinase C; Protein Kinase C beta; Pyrroles; Receptors, Antigen, B-Cell; Signal Transduction | 2007 |
Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cells.
Topics: Antimycin A; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzopyrans; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Mantle-Cell; Nitriles; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Splenic Neoplasms | 2006 |
[Chronic lymphocytic leukemia and loss of strength in the right arm--not a typical combination].
Topics: Administration, Oral; Aged; Antineoplastic Agents; Arm; Benzenesulfonates; Bone Neoplasms; Carcinoma, Renal Cell; Clinical Trials, Phase III as Topic; Disease Progression; Humans; Hypesthesia; Indoles; Kidney Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Liver Neoplasms; Lung Neoplasms; Magnetic Resonance Imaging; Male; Muscle Weakness; Neoplasms, Second Primary; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pyridines; Pyrroles; Radiography, Abdominal; Radiography, Thoracic; Risk; Risk Factors; Sex Factors; Sorafenib; Splenic Neoplasms; Sunitinib; Time Factors; Tomography, X-Ray Computed | 2007 |
Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 (NSC 694501) in chronic lymphocytic leukaemia cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzodiazepinones; Cross-Linking Reagents; DNA; DNA Repair; DNA-Binding Proteins; Drug Synergism; Endonucleases; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Pyrroles; Transcription, Genetic; Tumor Cells, Cultured; Vidarabine | 2007 |