Page last updated: 2024-08-18

pyrroles and Astrocytoma, Grade IV

pyrroles has been researched along with Astrocytoma, Grade IV in 56 studies

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (1.79)	18.2507
2000's	10 (17.86)	29.6817
2010's	41 (73.21)	24.3611
2020's	4 (7.14)	2.80

Authors

Authors	Studies
Brahm, CG; de Goeij-de Haas, R; De Witt Hamer, PC; Dekker, H; Henneman, AA; Honeywell, RJ; Hovinga, KE; Jiménez, CR; Knol, JC; Labots, M; Peters, GJ; Pham, TV; Piersma, SR; van Linde, ME; Vandertop, WP; Verheul, HMW	1
Fermi, V; Herold-Mende, C; Regulska, E; Romero-Nieto, C; Rominger, F; Wessling, P; Wolfram, A	1
Bai, R; Biagioni, S; Cavallini, C; Coluccia, A; Coluccia, AML; Da Pozzo, E; Hamel, E; La Regina, G; Liu, T; Martini, C; Mazzoccoli, C; Mazzoni, C; Nalli, M; Orlando, V; Puxeddu, M; Shen, H; Silvestri, R	1
Mason, WP; Richardson, PG; Roth, P; Weller, M	1
Burghardt, I; Papa, E; Szabó, E; Ventura, E; Weiss, T; Weller, M	1
Boger, DL; Boyle, KE; Vazquez, M; Wroe, A	1
Agati, R; Bartolini, S; Brandes, AA; Di Battista, M; Franceschi, E; Genestreti, G; Lamberti, G; Minichillo, S; Mura, A; Paccapelo, A	1
Baeza-Kallee, N; Cappaï, J; Chocry, M; Colin, C; Figarella-Branger, D; Kovacic, H; Lafitte, D; Nuccio, C; Quillien, V; Raujol, J; Rougon, G; Soubéran, A; Tchoghandjian, A	1
Deng, Q; Huang, Y; Lee, CS; Li, S; Li, X; Liu, F; Liu, Z; Qing, W; Wang, H	1
Lei, C; Shuyun, H; Xiangrong, C; Yiquan, K; Yongjun, Y; Zhilin, Y	1
Bonezzi, K; Borsotti, P; Cvitkovic, E; D'Incalci, M; Frapolli, R; Giavazzi, R; Noel, K; Sala, F; Taraboletti, G; Ubezio, P; Zangarini, M; Zucchetti, M	1
Buchroithner, J; Capper, D; Embacher, S; Gotwald, T; Haybaeck, J; Herrlinger, U; Holzner, B; Hutterer, M; Marosi, C; Moik, M; Nowosielski, M; Oberndorfer, S; Preusser, M; Seiz, M; Stockhammer, F; Stockhammer, G; Tuettenberg, J; Vajkoczy, P; Wick, A	1
Balaña, C; Capellades, J; Gallego, O; Gil, MJ; Gonzalez, S; Perez, P; Reynes, G; Ribalta, T; Verger, E	1
Jia, B; Liu, H; Liu, Z; Ma, T; Shi, J; Sun, X; Wang, F; Wu, Y; Yu, X; Zhao, H	1
Burrell, K; Chung, C; Foltz, W; Hill, R; Jalali, S; Singh, S; Zadeh, G	1
Bao, X; Wang, MW; Zhang, YJ; Zhang, YP	1
Coquerel, B; Demange, E; Kassim, Y; Le Cerf, D; Perrot, V; Petit, A; Simon, T; Vannier, JP	1
Corbacioglu, S; Debatin, KM; Engelke, J; Fulda, S; Halatsch, ME; Karpel-Massler, G; Nonnenmacher, L; Simmet, T; Westhoff, MA	1
Barnhart, TE; Cai, W; Chen, F; Goel, S; Hernandez, R; Hong, H; Shi, S; Valdovinos, HF	1
Cheng, SY; Feng, H; Gao, WQ; Hou, Y; Hu, B; James, CD; Li, Y; Li, Z; Parsa, AT; Raizer, JJ; Sarkaria, JN; Xie, B; Yin, Y; Zhang, L; Zhang, W	1
Huo, L; Jiang, B; Liu, H; Liu, J; Liu, Z; Lu, J	1
Martinho, O; Reis, RM; Zucca, LE	1
Cardoso, AL; Costa, PM; Cunha, P; Custódia, C; Pedroso de Lima, MC; Pereira de Almeida, L	1
Butowski, N; Cloughesy, TF; Colman, H; De Groot, JF; Haidar, S; Hsu, HH; Huse, J; Ligon, KL; Marimuthu, A; Molinaro, AM; Nayak, L; Nolop, KB; Omuro, AM; Perry, A; Phillips, J; Prados, M; Wen, PY; West, BL	1
Bailey, CP; Bouchier-Hayes, L; Chandra, J; Johnson, B; Manton, CA; Singh, M	1
Baeza-Kallee, N; Colin, C; Denicolaï, E; El-Battari, A; Figarella-Branger, D; Jiguet-Jiglaire, C; Soubéran, A; Tabouret, E; Tchoghandjian, A; Villard, C	1
Jiang, X; Qi, B; Wang, Z; Xia, H; Zhou, T	1
Burbidge, S; Colapietro, A; Delle Monache, S; Festuccia, C; Gravina, GL; Mancini, A; Marampon, F; Patient, L; Richardson, PJ; Sferra, R; Vitale, F	1
Rivera-Delgado, E; von Recum, HA	1
de Barros e Silva, MJ; de Paiva, TF; Fanelli, MF; Gimenes, DL; Rinck, JA	1
Czabanka, M; Heppner, F; Ullrich, A; Vajkoczy, P; Vinci, M	1
Abdulkarim, B; Aghi, M; Chahal, M; Christensen, JG; Famulski, K; Graham, K; Jacques, A; Lesniak, D; Murray, D; Sabri, S; Xu, Y	1
Gariboldi, MB; Monti, E; Ravizza, R	1
Jane, EP; Pollack, IF; Premkumar, DR	1
Argyriou, AA; Dimitropoulos, K; Giannopoulou, E; Kalofonos, HP; Petsas, T; Tsiata, E; Zolota, V	1
Beer, AJ; Schwaiger, M	1
Allen, L; Barnett, J; Battle, MR; Goggi, JL; Morrison, MS	1
Bielen, A; Box, GM; de Haven Brandon, A; Eccles, SA; Gowan, S; Hargrave, D; Hofmann, F; Jeay, S; Jones, C; Jury, A; Martins, V; Perryman, L; Popov, S; Raynaud, FI; Valenti, M	1
Han, N; Hauser, K; Herion, TW; Huber, PE; Lahn, M; Peschke, P; Timke, C; Weber, KJ; Wirkner, U; Zhang, M	1
Debus, J; Han, N; Huber, PE; Kleber, S; Lahn, M; Martin-Villalba, A; Peschke, P; Röhrich, M; Timke, C; Tuettenberg, J; Wirkner, U; Zhang, M	1
Cho, G; Kang, JS; Kang, MR; Kim, JK; Kim, YR; Lee, CK; Park, SB; Song, Y; Suh, JY	1
Bruce, JN; Canoll, P; Christensen, JG; Crisman, C; D'Amico, R; Ebiana, V; Gil, O; Kennedy, BC; Lei, L; Rosenfeld, SS; Sisti, J	1
Barcellos-Hoff, MH; Hardee, ME; Lonning, SM; Marciscano, AE; Medina-Ramirez, CM; Narayana, A; Zagzag, D	1
de Groot, JF; Henry, V; Heymach, JV; Holmes, L; Liang, J; Piao, Y; Zurita, AJ	1
Gallia, GL; Joshi, AD; Loilome, W; Riggins, GJ; Siu, IM; Tyler, B	1
Fine, HA; Iwamoto, FM; Kreisl, TN; Salgado, C; Shih, JH; Smith, P; Sul, J	1
Bruce, JN; Canoll, P; Cardoso, AL; Costa, PM; Nóbrega, C; Pedroso de Lima, MC; Pereira de Almeida, LF	1
Fueller, T; Hummel, V; Rieckmann, P; Tonn, JC; Wagner, S	1
Donnelly, E; Geng, L; Hallahan, DE; Himmelfarb, E; McMahon, G; Mendel, D; Schueneman, AJ; Tan, J	1
Abdollahi, A; Bischof, M; Debus, J; Grone, HJ; Hahnfeldt, P; Han, X; Hlatky, L; Huber, PE; Klenke, F; Krix, M; Lipson, KE; Poerschke, D; Roth, A; Sckell, A; Zieher, H	1
Bernsen, HJ; Bussink, J; Peeters, W; Schuuring, J; van Der Kogel, AJ	1
Christensen, JG; de Boüard, S; Gauduchon, P; Guillamo, JS; Herlin, P; Lemoisson, E; Raymond, E	1
Halmos, G; Kiaris, H; Nagy, A; Schally, AV; Sun, B; Szepeshazi, K	1
Hirth, KP; Menger, MD; Schilling, L; Schmiedek, P; Thurnher, A; Ullrich, A; Vajkoczy, P	1
Fong, TA; Hirth, KP; Menger, MD; Schilling, L; Schmiedek, P; Ullrich, A; Vajkoczy, P; Vollmar, B	1
Donnelly, E; Geng, L; Hallahan, DE; Lin, PC; McMahon, G; Oshinka, H; Sierra-Rivera, E	1

Reviews

1 review(s) available for pyrroles and Astrocytoma, Grade IV

Article	Year
Proteasome inhibition for the treatment of glioblastoma. Expert opinion on investigational drugs, 2020, Volume: 29, Issue:10 Topics: Animals; Antineoplastic Agents; Bortezomib; Brain Neoplasms; Drug Development; Glioblastoma; Humans; Lactones; Proteasome Inhibitors; Pyrroles	2020

Trials

4 trial(s) available for pyrroles and Astrocytoma, Grade IV

Article	Year
A single-arm phase II Austrian/German multicenter trial on continuous daily sunitinib in primary glioblastoma at first recurrence (SURGE 01-07). Neuro-oncology, 2014, Volume: 16, Issue:1 Topics: Adult; Aged; Angiogenesis Inhibitors; Brain Neoplasms; Drug Administration Schedule; Female; Follow-Up Studies; Glioblastoma; Humans; Indoles; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Prospective Studies; Pyrroles; Sunitinib; Survival Rate	2014
Sunitinib administered prior to radiotherapy in patients with non-resectable glioblastoma: results of a phase II study. Targeted oncology, 2014, Volume: 9, Issue:4 Topics: Aged; Antineoplastic Agents; Biopsy; Brain Neoplasms; Disease Progression; Disease-Free Survival; Female; Glioblastoma; Humans; Indoles; Magnetic Resonance Imaging; Male; Middle Aged; Pyrroles; Radiotherapy; Sunitinib; Time Factors; Treatment Outcome	2014
Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study. Neuro-oncology, 2016, Volume: 18, Issue:4 Topics: Administration, Oral; Aminopyridines; Biomarkers, Tumor; Blood-Brain Barrier; Brain Neoplasms; Cohort Studies; Female; Follow-Up Studies; Glioblastoma; Humans; Immunoenzyme Techniques; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Tissue Distribution; Tumor Burden	2016
Continuous daily sunitinib for recurrent glioblastoma. Journal of neuro-oncology, 2013, Volume: 111, Issue:1 Topics: Administration, Oral; Adult; Aged; Angiogenesis Inhibitors; Brain Neoplasms; Drug Administration Schedule; Female; Follow-Up Studies; Glioblastoma; Humans; Indoles; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Pyrroles; Quality of Life; Sunitinib; Survival Rate	2013

Other Studies

51 other study(ies) available for pyrroles and Astrocytoma, Grade IV

Article	Year
Tumor Drug Concentration and Phosphoproteomic Profiles After Two Weeks of Treatment With Sunitinib in Patients with Newly Diagnosed Glioblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2022, 04-14, Volume: 28, Issue:8 Topics: Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Humans; Indoles; Proteomics; Pyrroles; Sunitinib	2022
Luminescent Pyrrole-Based Phosphaphenalene Gold Complexes: Versatile Anticancer Tools with Wide Applicability. Chemistry (Weinheim an der Bergstrasse, Germany), 2022, Jun-15, Volume: 28, Issue:34 Topics: Antineoplastic Agents; Brain Neoplasms; Glioblastoma; Gold; Humans; Luminescence; Pyrroles	2022
Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies. European journal of medicinal chemistry, 2020, Jan-01, Volume: 185 Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Glioblastoma; Hematologic Neoplasms; Humans; Injections, Intraperitoneal; Injections, Subcutaneous; Mice; Mice, Inbred BALB C; Molecular Structure; Optical Imaging; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured	2020
Negative control of the HGF/c-MET pathway by TGF-β: a new look at the regulation of stemness in glioblastoma. Cell death & disease, 2017, 12-13, Volume: 8, Issue:12 Topics: Antineoplastic Agents; Butadienes; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Hepatocyte Growth Factor; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplastic Stem Cells; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Pteridines; Pyrazoles; Pyridazines; Pyrimidines; Pyrroles; Quinolines; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta	2017
Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation. Bioorganic & medicinal chemistry letters, 2018, 09-01, Volume: 28, Issue:16 Topics: Antibiotics, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Duocarmycins; Glioblastoma; Humans; Indoles; Necrosis; Protons; Pyrroles; Radiation-Sensitizing Agents	2018
Third-line therapy in recurrent glioblastoma: is it another chance for bevacizumab? Journal of neuro-oncology, 2018, Volume: 139, Issue:2 Topics: Acetanilides; Adult; Aged; Antineoplastic Agents, Immunological; Bevacizumab; Biomarkers, Tumor; Brain Neoplasms; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Pyrroles; Quinolines; Retreatment; Survival Analysis; Treatment Outcome; Tumor Suppressor Proteins; Young Adult	2018
Inhibitor of Apoptosis Proteins Determines Glioblastoma Stem-Like Cell Fate in an Oxygen-Dependent Manner. Stem cells (Dayton, Ohio), 2019, Volume: 37, Issue:6 Topics: Adaptor Proteins, Signal Transducing; Adrenomedullin; Apoptosis; Baculoviral IAP Repeat-Containing 3 Protein; Brain Neoplasms; Carbonic Anhydrase IX; Cell Differentiation; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cyclohexanes; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Inhibitor of Apoptosis Proteins; Neoplasm Proteins; Neoplastic Stem Cells; Oxygen; Pyrroles; Signal Transduction; Spheroids, Cellular; Tissue Culture Techniques; X-Linked Inhibitor of Apoptosis Protein	2019
Bis-diketopyrrolopyrrole conjugated polymer nanoparticles as photothermic nanoagonist for specific and synergistic glioblastoma therapy. Biomaterials, 2019, Volume: 216 Topics: Animals; Cell Line, Tumor; Female; Glioblastoma; Humans; Hyperthermia, Induced; Ketones; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Phototherapy; Pyrroles	2019
Atorvastatin suppresses glioma invasion and migration by reducing microglial MT1-MMP expression. Journal of neuroimmunology, 2013, Jul-15, Volume: 260, Issue:1-2 Topics: Atorvastatin; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioblastoma; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; MAP Kinase Signaling System; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Microglia; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Pyrroles	2013
Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib. Cancer chemotherapy and pharmacology, 2013, Volume: 72, Issue:4 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Calixarenes; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Endothelial Cells; Female; Galectin 1; Glioblastoma; Half-Life; Humans; Indoles; Inhibitory Concentration 50; Mice; Mice, Nude; Molecular Targeted Therapy; Ovarian Neoplasms; Pyrroles; Sunitinib; Tissue Distribution; Xenograft Model Antitumor Assays	2013
Longitudinal monitoring of tumor antiangiogenic therapy with near-infrared fluorophore-labeled agents targeted to integrin αvβ3 and vascular endothelial growth factor. European journal of nuclear medicine and molecular imaging, 2014, Volume: 41, Issue:7 Topics: Animals; Colonic Neoplasms; Fluorescent Dyes; Glioblastoma; HT29 Cells; Humans; Indoles; Infrared Rays; Integrin alphaVbeta3; Longitudinal Studies; Mice; Molecular Targeted Therapy; Neovascularization, Pathologic; Optical Imaging; Pyrroles; Sunitinib; Vascular Endothelial Growth Factor A	2014
MRI biomarkers identify the differential response of glioblastoma multiforme to anti-angiogenic therapy. Neuro-oncology, 2014, Volume: 16, Issue:6 Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Bevacizumab; Biomarkers; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Glioblastoma; Humans; Image Processing, Computer-Assisted; Indoles; Magnetic Resonance Imaging; Mice; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Sunitinib	2014
Early monitoring antiangiogenesis treatment response of Sunitinib in U87MG Tumor Xenograft by (18)F-FLT MicroPET/CT imaging. BioMed research international, 2014, Volume: 2014 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Dideoxynucleosides; Drug Monitoring; Early Detection of Cancer; Female; Glioblastoma; Indoles; Mice; Mice, Inbred C57BL; Mice, Nude; Multimodal Imaging; Positron-Emission Tomography; Pyrroles; Radiopharmaceuticals; Sunitinib; Tomography, X-Ray Computed; Treatment Outcome	2014
Direct effect of bevacizumab on glioblastoma cell lines in vitro. Neuromolecular medicine, 2014, Volume: 16, Issue:4 Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Autocrine Communication; Bevacizumab; Brain Neoplasms; Calcium Signaling; Cell Culture Techniques; Cell Division; Cell Line, Tumor; Cell Movement; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hyaluronic Acid; Hydrogels; Indoles; MAP Kinase Signaling System; Neoplasm Invasiveness; Neoplasm Proteins; Placenta Growth Factor; Pregnancy Proteins; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrroles; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2	2014
RIST: a potent new combination therapy for glioblastoma. International journal of cancer, 2015, Feb-15, Volume: 136, Issue:4 Topics: Adolescent; Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Cell Line, Tumor; Child; Dacarbazine; Female; Glioblastoma; Humans; Indoles; Irinotecan; Male; Membrane Potential, Mitochondrial; Mice, Inbred NOD; Molecular Targeted Therapy; Pyrroles; Sirolimus; Sunitinib; Temozolomide; Xenograft Model Antitumor Assays	2015
VEGF₁₂₁-conjugated mesoporous silica nanoparticle: a tumor targeted drug delivery system. ACS applied materials & interfaces, 2014, Dec-10, Volume: 6, Issue:23 Topics: Animals; Drug Delivery Systems; Glioblastoma; Glioma; Humans; Indoles; Mice; Nanoparticles; Pyrroles; Silicon Dioxide; Sunitinib; Vascular Endothelial Growth Factor Receptor-1; Xenograft Model Antitumor Assays	2014
Protein kinase A-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived-growth factor receptor α. Neuro-oncology, 2015, Volume: 17, Issue:6 Topics: Animals; Brain Neoplasms; Carbazoles; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Female; Glioblastoma; HEK293 Cells; Humans; Isoquinolines; Mice; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pyrroles; rac GTP-Binding Proteins; Receptor, Platelet-Derived Growth Factor alpha; Signal Transduction; Sulfonamides	2015
Synthetic miR-145 Mimic Enhances the Cytotoxic Effect of the Antiangiogenic Drug Sunitinib in Glioblastoma. Cell biochemistry and biophysics, 2015, Volume: 72, Issue:2 Topics: Angiogenesis Inhibitors; Apoptosis; Cell Line; Glioblastoma; Humans; Indoles; MicroRNAs; Pyrroles; Sunitinib	2015
AXL as a modulator of sunitinib response in glioblastoma cell lines. Experimental cell research, 2015, Mar-01, Volume: 332, Issue:1 Topics: Angiogenesis Inhibitors; Axl Receptor Tyrosine Kinase; Cell Line, Tumor; Cell Movement; Cell Survival; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Activation; ErbB Receptors; Gene Knockdown Techniques; Glioblastoma; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Proto-Oncogene Proteins; Pyrroles; Receptor Protein-Tyrosine Kinases; Signal Transduction; Sunitinib	2015
MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma. Journal of controlled release : official journal of the Controlled Release Society, 2015, Jun-10, Volume: 207 Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Chemotherapy, Adjuvant; Drug Carriers; Gene Expression Regulation, Neoplastic; Glioblastoma; Indoles; Male; Mice, Inbred C57BL; MicroRNAs; Nanomedicine; Nanoparticles; Oligonucleotides, Antisense; Protein Kinase Inhibitors; Pyrroles; rhoB GTP-Binding Protein; RNAi Therapeutics; Scorpion Venoms; Sunitinib; Technology, Pharmaceutical; Time Factors; Tumor Burden	2015
Induction of cell death by the novel proteasome inhibitor marizomib in glioblastoma in vitro and in vivo. Scientific reports, 2016, Jan-25, Volume: 6 Topics: Animals; Apoptosis; Biomarkers, Tumor; Bortezomib; Caspases; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Lactones; Mice; Proliferating Cell Nuclear Antigen; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles	2016
Inhibitor of apoptosis protein expression in glioblastomas and their in vitro and in vivo targeting by SMAC mimetic GDC-0152. Cell death & disease, 2016, 08-04, Volume: 7, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromatography; Cyclohexanes; Glioblastoma; Humans; Immunohistochemistry; Inhibitor of Apoptosis Proteins; Mice, Nude; Middle Aged; Molecular Targeted Therapy; Paraffin Embedding; Prognosis; Pyrroles; Tissue Fixation; Young Adult	2016
HSP47 Promotes Glioblastoma Stemlike Cell Survival by Modulating Tumor Microenvironment Extracellular Matrix through TGF-β Pathway. ACS chemical neuroscience, 2017, 01-18, Volume: 8, Issue:1 Topics: Analysis of Variance; Animals; Brain Neoplasms; Cell Survival; Computational Biology; Disease Models, Animal; Extracellular Matrix; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glioblastoma; HSP47 Heat-Shock Proteins; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplastic Stem Cells; Platelet Endothelial Cell Adhesion Molecule-1; Pyrazoles; Pyrroles; RNA, Messenger; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Microenvironment; Xenograft Model Antitumor Assays	2017
The brain-penetrating CXCR4 antagonist, PRX177561, increases the antitumor effects of bevacizumab and sunitinib in preclinical models of human glioblastoma. Journal of hematology & oncology, 2017, 01-05, Volume: 10, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain; Brain Neoplasms; Cell Line, Tumor; Drug Evaluation, Preclinical; Drug Interactions; Drug Synergism; Glioblastoma; Heterografts; Humans; Indoles; Mice; Pyrroles; Receptors, CXCR4; Sunitinib	2017
Using Affinity To Provide Long-Term Delivery of Antiangiogenic Drugs in Cancer Therapy. Molecular pharmaceutics, 2017, 03-06, Volume: 14, Issue:3 Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cellulose; Cyclodextrins; Drug Delivery Systems; Estradiol; Female; Glioblastoma; Humans; Indoles; Mice; Mice, Nude; ortho-Aminobenzoates; Pyrroles; Silybin; Silymarin	2017
Tuberculosis in a patient on temozolomide: a case report. Journal of neuro-oncology, 2009, Volume: 92, Issue:1 Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antibiotics, Antitubercular; Anticholesteremic Agents; Anticonvulsants; Antineoplastic Agents, Alkylating; Atorvastatin; Brain Neoplasms; Combined Modality Therapy; Cyclosporine; Dacarbazine; Dexamethasone; Female; Fluoxetine; Glioblastoma; Heptanoic Acids; Humans; Immunosuppressive Agents; Isoniazid; Middle Aged; Omeprazole; Phenobarbital; Prednisone; Pyrazinamide; Pyrroles; Radiotherapy; Red-Cell Aplasia, Pure; Rifampin; Temozolomide; Trimethoprim, Sulfamethoxazole Drug Combination; Tuberculosis, Pulmonary	2009
Effects of sunitinib on tumor hemodynamics and delivery of chemotherapy. International journal of cancer, 2009, Mar-15, Volume: 124, Issue:6 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Division; Cell Line, Tumor; Desmin; Doxorubicin; Glioblastoma; Hemodynamics; Indoles; Mice; Mice, Nude; Microcirculation; Pyrroles; Sunitinib	2009
MGMT modulates glioblastoma angiogenesis and response to the tyrosine kinase inhibitor sunitinib. Neuro-oncology, 2010, Volume: 12, Issue:8 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Separation; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression; Gene Expression Profiling; Glioblastoma; Humans; Indoles; Mice; Mice, Nude; Neovascularization, Pathologic; Protein Kinase Inhibitors; Pyrroles; Radiotherapy; Reverse Transcriptase Polymerase Chain Reaction; Sunitinib; Temozolomide; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays	2010
The IGFR1 inhibitor NVP-AEW541 disrupts a pro-survival and pro-angiogenic IGF-STAT3-HIF1 pathway in human glioblastoma cells. Biochemical pharmacology, 2010, Aug-15, Volume: 80, Issue:4 Topics: Angiogenesis Inhibitors; Cell Line, Tumor; Cell Survival; Drug Synergism; Glioblastoma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin-Like Growth Factor I; Pyrimidines; Pyrroles; Receptor, IGF Type 1; STAT3 Transcription Factor	2010
Co-administration of NVP-AEW541 and dasatinib induces mitochondrial-mediated apoptosis through Bax activation in malignant human glioma cell lines. International journal of oncology, 2010, Volume: 37, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Cell Cycle; Cell Cycle Proteins; Cell Growth Processes; Cell Line, Tumor; Dasatinib; Drug Synergism; Fluorescent Antibody Technique; Glioblastoma; Humans; Mitochondria; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; Thiazoles; Transfection	2010
The effects of anti-VEGFR and anti-EGFR agents on glioma cell migration through implication of growth factors with integrins. Anticancer research, 2010, Volume: 30, Issue:12 Topics: Cell Line, Tumor; Cell Movement; ErbB Receptors; Focal Adhesion Kinase 1; Glioblastoma; Humans; Indoles; Integrin beta1; Integrin beta3; Integrins; Lapatinib; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Sunitinib; Vascular Endothelial Growth Factor Receptor-1	2010
PET of αvbeta3-integrin and αvbeta5-integrin expression with 18F-fluciclatide for assessment of response to targeted therapy: ready for prime time? Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Volume: 52, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Glioblastoma; Humans; Indoles; Integrin alphaVbeta3; Male; Mice; Mice, Nude; Peptides; Polyethylene Glycols; Pyrroles; Radionuclide Imaging; Radiopharmaceuticals; Receptors, Vitronectin; Reproducibility of Results; Sensitivity and Specificity; Sunitinib	2011
Monitoring tumor response to antiangiogenic sunitinib therapy with 18F-fluciclatide, an 18F-labeled αVbeta3-integrin and αV beta5-integrin imaging agent. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Volume: 52, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Glioblastoma; Humans; Indoles; Integrin alphaVbeta3; Male; Mice; Mice, Nude; Peptides; Polyethylene Glycols; Pyrroles; Radionuclide Imaging; Radiopharmaceuticals; Receptors, Vitronectin; Reproducibility of Results; Sensitivity and Specificity; Sunitinib	2011
Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRα/β. Molecular cancer therapeutics, 2011, Volume: 10, Issue:8 Topics: Animals; Antineoplastic Agents; Autophagy; Cell Line, Tumor; Child; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Mice; Mice, Nude; Neoplasm Staging; Phosphatidylinositol 3-Kinases; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Receptor, Platelet-Derived Growth Factor alpha; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Xenograft Model Antitumor Assays	2011
Trimodal glioblastoma treatment consisting of concurrent radiotherapy, temozolomide, and the novel TGF-β receptor I kinase inhibitor LY2109761. Neoplasia (New York, N.Y.), 2011, Volume: 13, Issue:6 Topics: Angiopoietin-1; Angiopoietin-2; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Cells, Cultured; Combined Modality Therapy; Dacarbazine; Gene Expression Regulation, Neoplastic; Glioblastoma; Immunohistochemistry; Ki-67 Antigen; Mice; Mice, Inbred BALB C; Mice, Nude; Platelet Endothelial Cell Adhesion Molecule-1; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Radiotherapy; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; Temozolomide; Tumor Burden; Xenograft Model Antitumor Assays	2011
Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma. Cancer research, 2011, Dec-01, Volume: 71, Issue:23 Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA Damage; DNA Repair; Glioblastoma; Humans; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, SCID; Microarray Analysis; Neoplasm Invasiveness; Neoplastic Stem Cells; Neovascularization, Pathologic; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Radiation Tolerance; Radiation-Sensitizing Agents; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta; Xenograft Model Antitumor Assays	2011
Is apparent diffusion coefficient reliable and accurate for monitoring effects of antiangiogenic treatment in a longitudinal study? Journal of magnetic resonance imaging : JMRI, 2012, Volume: 35, Issue:6 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Diffusion Magnetic Resonance Imaging; Female; Glioblastoma; Image Enhancement; Image Interpretation, Computer-Assisted; Indoles; Longitudinal Studies; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Pyrroles; Reproducibility of Results; Sensitivity and Specificity; Sunitinib; Treatment Outcome	2012
The addition of Sunitinib to radiation delays tumor growth in a murine model of glioblastoma. Neurological research, 2012, Volume: 34, Issue:3 Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Disease Models, Animal; Disease Progression; Glioblastoma; Indoles; Mice; Mice, Transgenic; Pyrroles; Radiation Dosage; Sunitinib	2012
Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β. Cancer research, 2012, Aug-15, Volume: 72, Issue:16 Topics: Animals; Antibodies, Neutralizing; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; DNA Damage; DNA, Neoplasm; Female; Glioblastoma; Humans; Mice; Mice, Inbred C57BL; Mink; Neoplastic Stem Cells; Neural Stem Cells; Pyrazoles; Pyrroles; Radiation Tolerance; Radiation-Sensitizing Agents; Signal Transduction; Transforming Growth Factor beta; Tumor Microenvironment	2012
Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype. Neuro-oncology, 2012, Volume: 14, Issue:11 Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Cell Hypoxia; Cell Line, Tumor; Drug Resistance, Neoplasm; Flow Cytometry; Glioblastoma; Humans; Immunohistochemistry; Indoles; Mesoderm; Mice; Mice, Nude; Myeloid Cells; Neovascularization, Pathologic; Phenotype; Pyrroles; Real-Time Polymerase Chain Reaction; Receptors, Vascular Endothelial Growth Factor; Stem Cells; Sunitinib; Tumor Microenvironment; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays	2012
Evaluation of tyrosine kinase inhibitor combinations for glioblastoma therapy. PloS one, 2012, Volume: 7, Issue:10 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Evaluation, Preclinical; Drug Synergism; Female; Gefitinib; Glioblastoma; Humans; Immunoblotting; Indoles; Inhibitory Concentration 50; Mice; Mice, Nude; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Quinazolines; Rats, Inbred F344; Spheroids, Cellular; Sunitinib; Treatment Outcome; Xenograft Model Antitumor Assays	2012
MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma. Human molecular genetics, 2013, Mar-01, Volume: 22, Issue:5 Topics: Angiogenesis Inhibitors; Animals; Apoptosis Regulatory Proteins; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Indoles; Mice; MicroRNAs; PTEN Phosphohydrolase; Pyrroles; RNA-Binding Proteins; Signal Transduction; Sunitinib; Up-Regulation	2013
Influence of VEGF-R2 inhibition on MMP secretion and motility of microvascular human cerebral endothelial cells (HCEC). Journal of neuro-oncology, 2003, Volume: 62, Issue:3 Topics: Angiogenesis Inhibitors; Brain Neoplasms; Cell Movement; Cerebral Cortex; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Glioblastoma; Humans; Immunoenzyme Techniques; In Vitro Techniques; Indoles; Interleukin-10; Matrix Metalloproteinases; Microcirculation; Neovascularization, Pathologic; Protein-Tyrosine Kinases; Pyrroles; Spheroids, Cellular; Tumor Cells, Cultured; Umbilical Veins; Vascular Endothelial Growth Factor Receptor-2	2003
SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer research, 2003, Jul-15, Volume: 63, Issue:14 Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Lewis Lung; Combined Modality Therapy; Endothelium, Vascular; Glioblastoma; Humans; Indoles; Mice; Mice, Inbred C57BL; Neoplasm Recurrence, Local; Neoplasms, Experimental; Neovascularization, Pathologic; Pyrroles; Receptor Protein-Tyrosine Kinases; Sunitinib	2003
Combined therapy with direct and indirect angiogenesis inhibition results in enhanced antiangiogenic and antitumor effects. Cancer research, 2003, Dec-15, Volume: 63, Issue:24 Topics: Adenocarcinoma; Angiogenesis Inhibitors; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Movement; Cell Survival; Drug Synergism; Endostatins; Endothelium, Vascular; Female; Glioblastoma; Humans; Indoles; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, SCID; Neoplasms; Neovascularization, Pathologic; Prostatic Neoplasms; Pyrroles; Ultrasonography; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays	2003
Irradiation combined with SU5416: microvascular changes and growth delay in a human xenograft glioblastoma tumor line. International journal of radiation oncology, biology, physics, 2005, Feb-01, Volume: 61, Issue:2 Topics: Angiogenesis Inhibitors; Animals; Cell Hypoxia; Cell Line, Tumor; Combined Modality Therapy; Dose-Response Relationship, Radiation; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Indoles; Mice; Mice, Inbred BALB C; Mice, Nude; Microcirculation; Necrosis; Pyrroles; Recurrence; Remission Induction; Transplantation, Heterologous	2005
Antiangiogenic and anti-invasive effects of sunitinib on experimental human glioblastoma. Neuro-oncology, 2007, Volume: 9, Issue:4 Topics: Angiogenesis Inhibitors; Animals; Blotting, Western; Brain; Brain Neoplasms; Cell Line, Tumor; Flow Cytometry; Focal Adhesion Protein-Tyrosine Kinases; Glioblastoma; Humans; Immunohistochemistry; Immunoprecipitation; Indoles; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Neovascularization, Pathologic; Organ Culture Techniques; Phosphorylation; Pyrroles; src-Family Kinases; Sunitinib; Xenograft Model Antitumor Assays	2007
Regression of U-87 MG human glioblastomas in nude mice after treatment with a cytotoxic somatostatin analog AN-238. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:2 Topics: Animals; Antibiotics, Antineoplastic; Body Weight; Cell Survival; Doxorubicin; Glioblastoma; Humans; Male; Mice; Mice, Nude; Octreotide; Pyrroles; Transfection; Tumor Cells, Cultured	2000
Measuring VEGF-Flk-1 activity and consequences of VEGF-Flk-1 targeting in vivo using intravital microscopy: clinical applications. The oncologist, 2000, Volume: 5 Suppl 1 Topics: Analysis of Variance; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Endothelial Growth Factors; Enzyme Inhibitors; Glioblastoma; Indoles; Lymphokines; Male; Mice; Mice, Nude; Microcirculation; Microscopy, Fluorescence; Microscopy, Video; Neoplasm Transplantation; Neovascularization, Pathologic; Protein Isoforms; Protein-Tyrosine Kinases; Pyrroles; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Mitogen; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Skin Neoplasms; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2000
Inhibition of tumor growth, angiogenesis, and microcirculation by the novel Flk-1 inhibitor SU5416 as assessed by intravital multi-fluorescence videomicroscopy. Neoplasia (New York, N.Y.), 1999, Volume: 1, Issue:1 Topics: Animals; Antineoplastic Agents; Enzyme Inhibitors; Glioblastoma; Indoles; Male; Mice; Mice, Nude; Microcirculation; Neovascularization, Pathologic; Pyrroles; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor	1999
Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy. Cancer research, 2001, Mar-15, Volume: 61, Issue:6 Topics: Angiogenesis Inhibitors; Animals; Cell Survival; Dose-Response Relationship, Radiation; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Glioblastoma; Indoles; Lymphokines; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Pyrroles; Radiation Tolerance; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2001