pyrroles and Anoxemia

Topics: Animals; Disease Models, Animal; Disease Progression; Humans; Hypoxia; Indoles; MAP Kinase Signaling System; Mice; Mice, Knockout; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats

Topics: Angiogenesis Inhibitors; Angiopoietins; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Ephrins; Humans; Hypoxia; Indoles; Lung; Lung Diseases; Pleural Diseases; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Transcription, Genetic; Vascular Endothelial Growth Factor A

Topics: Adenosine Triphosphate; Adolescent; Adult; Altitude; Animals; Blood Glucose; Calcium; Corticosterone; Corticotropin-Releasing Hormone; Cyclic AMP; Humans; Hydrocortisone; Hypoxia; Insulin; Male; Pancreas; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Young Adult

Topics: Administration, Inhalation; Adult; Atorvastatin; Brachial Artery; Cardiovascular Diseases; Cholesterol; Endothelium, Vascular; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Hyperoxia; Hypoxia; Lipoproteins; Male; Middle Aged; Nitroglycerin; Oxygen; Pyrroles; Regional Blood Flow; Research Design; Risk Factors; Treatment Outcome; Triglycerides; Ultrasonography; Vasoconstriction; Vasodilation; Vasodilator Agents

Topics: Administration, Inhalation; Administration, Oral; Animals; Collagen; Disease Models, Animal; Epoprostenol; Heart; Hemodynamics; Hypoxia; Indoles; Male; Myocardium; Phosphodiesterase 5 Inhibitors; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Sildenafil Citrate; Vascular Remodeling; Vasodilator Agents

Topics: Animals; Diaphragm; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Interleukin-1 Receptor-Like 1 Protein; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Mitochondrial Diseases; Muscle Contraction; Protein Kinase Inhibitors; Pulmonary Arterial Hypertension; Pyrroles

Topics: Animals; Cell Proliferation; Heart Ventricles; Humans; Hypoxia; Indoles; Isoquinolines; Lung; Male; Metabolome; Myosin Light Chains; Phosphorylation; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pyrroles; Rats, Sprague-Dawley; Sulfonamides; TOR Serine-Threonine Kinases; Vascular Remodeling

Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Mineralocorticoid Receptor Antagonists; Pulmonary Arterial Hypertension; Pyrroles; Rats; Ventricular Dysfunction, Right

Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Hypoxia; Liver Neoplasms; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Sorafenib; Sulfonamides

Topics: Animals; Cell Line, Tumor; Hydrogen Peroxide; Hypoxia; Magnetic Phenomena; Mice; Mice, Nude; Nanoparticles; Neoplasms; Photochemotherapy; Photosensitizing Agents; Photothermal Therapy; Polymers; Pyrroles; Silicon Dioxide

Topics: Humans; Hypoxia; Neoplasms; Photochemotherapy; Photosensitizing Agents; Pyrroles; Reactive Oxygen Species; Recurrence

Topics: Humans; Hypoxia; Ion Exchange; Iron; Oxygen; Pyrroles

Topics: Animals; Emphysema; Hypertension, Pulmonary; Hypoxia; Indoles; Phenotype; Pulmonary Arterial Hypertension; Pyrroles; Rats

Topics: Animals; Emphysema; Hypertension, Pulmonary; Hypoxia; Indoles; Phenotype; Pulmonary Arterial Hypertension; Pyrroles; Rats

Topics: Angiogenesis Inhibitors; Animals; Calcium; Cells, Cultured; Endothelial Cells; Hypoxia; Indoles; Lung; Male; Mitochondria; Oxygen Consumption; Pulmonary Arterial Hypertension; Pyrroles; Rats; Rats, Wistar; Reactive Oxygen Species; Vascular Remodeling

Topics: Animals; Extracellular Vesicles; Fibroblasts; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Macrophage Activation; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; MicroRNAs; Muscle, Smooth; Neovascularization, Physiologic; Pyrroles; Rats, Sprague-Dawley; Vascular Remodeling; von Willebrand Factor

Topics: Animals; Emphysema; Hypertension, Pulmonary; Hypoxia; Indoles; Pyrroles; Rats; Rats, Sprague-Dawley

Topics: Adult; Animals; Emphysema; Hypertension, Pulmonary; Hypoxia; Indoles; Pulmonary Emphysema; Pyrroles; Rats; Receptors, Vascular Endothelial Growth Factor

Topics: Animals; Cells, Cultured; Chronic Disease; Disease Models, Animal; Endothelial Cells; Epithelial-Mesenchymal Transition; Glucosides; Humans; Hypoxia; Indoles; Injections, Subcutaneous; Male; Monoterpenes; Oxygen; Pulmonary Arterial Hypertension; Pyrroles; Rats; Rats, Sprague-Dawley

Topics: Amides; Animals; Chronic Disease; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Eicosanoids; Hypertension, Pulmonary; Hypoxia; Ion Channel Gating; Male; Mice, Inbred C57BL; Morpholines; Pulmonary Artery; Pyrroles; Serotonin; TRPV Cation Channels; Vasoconstriction

Topics: Animals; Hypertension, Pulmonary; Hypoxia; Indoles; Pyrroles; Rats

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetamides; Animals; Cell Proliferation; Collagen Type I; Disease Models, Animal; Heart Ventricles; Hemodynamics; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Lung; Male; Pulmonary Arterial Hypertension; Pyrazines; Pyrroles; Rats, Sprague-Dawley; Receptors, Epoprostenol; Systole; Vascular Remodeling

Topics: Angiogenesis Inhibitors; Animals; Drug Therapy, Combination; Hypoxia; Indoles; Male; Pulmonary Arterial Hypertension; Pyrroles; Rats; Rats, Wistar; Receptors, Thromboxane A2, Prostaglandin H2; Sildenafil Citrate; Treatment Outcome; Vasodilator Agents

Topics: Animals; Antihypertensive Agents; Basigin; Cyclophilin A; Disease Models, Animal; Humans; Hypoxia; Indoles; Mice; Mice, Transgenic; Myocytes, Cardiac; Pentacyclic Triterpenes; Pulmonary Arterial Hypertension; Pyrroles; Rats; Triterpenes; Ventricular Dysfunction, Right

Topics: Animals; Antihypertensive Agents; Coronary Angiography; Coronary Vessels; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Monocrotaline; Predictive Value of Tests; Pulmonary Arterial Hypertension; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Severity of Illness Index; Sulfonamides; Synchrotrons; Vasodilation; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling

Topics: Animals; Citric Acid Cycle; Fatty Acids; Glucose; Heart Ventricles; Humans; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Oxidation-Reduction; Pulmonary Arterial Hypertension; Pyrroles; Rats; Rats, Sprague-Dawley; Ventricular Remodeling

Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Epithelial-Mesenchymal Transition; Female; Gene Expression Profiling; Heart Failure; Heart Ventricles; Humans; Hypoxia; Indoles; Male; Middle Aged; Monocrotaline; Pulmonary Arterial Hypertension; Pyrroles; Rats; Real-Time Polymerase Chain Reaction; RNA-Seq; Transcriptome; Ventricular Dysfunction, Right; Ventricular Remodeling

Topics: Angiogenesis Inhibitors; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Tracking; Disease Models, Animal; Female; Hypoxia; Indoles; Lung; Male; Neointima; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats; Transplantation Chimera; Vascular Remodeling

Topics: Animals; Antipsychotic Agents; Cardiovascular Agents; Cell Proliferation; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Repositioning; Female; Forkhead Box Protein O3; Gene Expression Regulation; Hemodynamics; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Survivin; Trifluoperazine

Topics: Animals; Blood Pressure; Capillaries; Disease Models, Animal; Endothelial Cells; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; In Situ Nick-End Labeling; Indoles; Male; MAP Kinase Signaling System; Myocardium; Myocytes, Cardiac; Oxidative Stress; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; RNA, Messenger; Ventricular Remodeling

Topics: Angiogenesis Inhibitors; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Renal Cell; Carrier Proteins; Cell Line, Tumor; Cytokines; Endothelial Cells; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Intracellular Signaling Peptides and Proteins; Kidney Neoplasms; Models, Biological; Protein Binding; Protein Kinase Inhibitors; Proteolysis; Pyrroles; Ribonucleoproteins, Small Nuclear; Sunitinib; Ubiquitination

Topics: Animals; Autophagy; Cell Proliferation; Endothelial Cells; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Indoles; Lung; Male; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor

Topics: Benzodiazepines; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Humans; Hypoxia; Molecular Structure; NADPH-Ferrihemoprotein Reductase; Prodrugs; Pyrroles; Structure-Activity Relationship

Topics: Angiogenesis Inhibitors; Animals; Calcium; Cells, Cultured; Endothelium, Vascular; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Microvessels; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; TRPV Cation Channels; Vascular Diseases

Topics: Animals; Cell Survival; Cells, Cultured; Curcumin; Hypertrophy; Hypertrophy, Right Ventricular; Hypoxia; Male; Mitochondria; Myocytes, Cardiac; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley

Topics: Adaptation, Physiological; Animals; Apoptosis; Cell Proliferation; Endothelial Cells; Female; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Mice, Inbred C57BL; Pyrroles; Rats, Sprague-Dawley

Topics: Animals; Biomarkers; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Contrast Media; Disease Models, Animal; Female; Humans; Hypoxia; Image Enhancement; Immunohistochemistry; Indoles; Magnetic Resonance Imaging; Male; Mice; Neovascularization, Pathologic; Pancreatic Neoplasms; Pyrroles; Sunitinib; Tumor Microenvironment; Xenograft Model Antitumor Assays

Topics: Adoptive Transfer; Adult; Animals; Antibodies; Blood Pressure; Bone Marrow; Cell Proliferation; Chimera; Chronic Disease; Disease Models, Animal; Female; Gene Deletion; Humans; Hypertension, Pulmonary; Hypoxia; Immunity; Indoles; Lung; Lymphocyte Activation; Male; Mice; Ovalbumin; Pulmonary Artery; Pyrroles; Receptors, Immunologic; Receptors, Prostaglandin; STAT6 Transcription Factor; Th2 Cells; Up-Regulation

Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Pulmonary Artery; Pyrroles; Vascular Remodeling

Topics: Angiogenesis Inhibitors; Animals; Antihypertensive Agents; Epoprostenol; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Protein Kinase Inhibitors; Pyrroles; Rats, Sprague-Dawley; Vascular Remodeling; Vasodilator Agents; Ventricular Function, Right

Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Mice; Pyrroles; Receptors, Vascular Endothelial Growth Factor

Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Mice; Pyrroles; Receptors, Vascular Endothelial Growth Factor

Topics: Animals; Caspase Inhibitors; Cysteine Endopeptidases; Extracellular Matrix Proteins; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Inflammation; Lung; Macrophages; Male; Matrix Metalloproteinase 2; Mice; Middle Aged; Monocrotaline; Pyrroles; Rats; Severity of Illness Index; Signal Transduction; Transforming Growth Factor beta1; Vascular Remodeling

Topics: Animals; Arterial Pressure; Cells, Cultured; Disease Models, Animal; Fibrosis; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Mesenchymal Stem Cell Transplantation; Myocardial Contraction; Myocardium; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Recovery of Function; Regeneration; Tissue Scaffolds; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling; von Willebrand Factor

Topics: Adolescent; Adult; Aged; Animals; Bone Morphogenetic Protein Receptors, Type II; Case-Control Studies; Caveolin 1; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Extracellular Vesicles; Female; Humans; Hypoxia; Indoles; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Nitric Oxide Synthase Type III; Pulmonary Arterial Hypertension; Pyrroles; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Vascular Remodeling; Young Adult

Topics: Angiogenic Proteins; Animals; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Cells, Cultured; Dependovirus; Disease Models, Animal; Genetic Therapy; Genetic Vectors; Hypertension, Pulmonary; Hypoxia; Indoles; Lung; Male; Mice, Inbred C57BL; MicroRNAs; Microvessels; Neovascularization, Physiologic; Pyrroles; Recovery of Function; Signal Transduction; Vascular Remodeling

Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Protein Kinase Inhibitors; Pulmonary Emphysema; Pyrroles; Rats; X-Ray Microtomography

Topics: Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Energy Metabolism; High-Throughput Screening Assays; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Male; Metabolome; Mice; Mitochondria; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthoquinones; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats; Reactive Oxygen Species; Resorcinols; Transcription Factors

Topics: Angiogenesis Inhibitors; Animals; Chronic Disease; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Pyrroles

Topics: Animals; Anticholesteremic Agents; Atorvastatin; Blood Pressure; Cardiovascular Diseases; Disease Models, Animal; Heptanoic Acids; Hypoxia; Oxidative Stress; Pyrroles; Rats; Treatment Outcome

Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Brain Neoplasms; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Immunohistochemistry; In Situ Hybridization; Indoles; Male; Meningioma; Middle Aged; Pyrroles; Sunitinib; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2

Topics: Animals; Apoptosis; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Drug Evaluation, Preclinical; Endothelial Cells; Gene Expression Regulation; Genes, p53; Humans; Hypertension, Pulmonary; Hypoxia; Imidazoles; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Phosphorylation; Piperazines; Protein Processing, Post-Translational; Protein Stability; Pulmonary Artery; Pyrroles; Serotonin Plasma Membrane Transport Proteins; Single-Blind Method; Tumor Suppressor Protein p53; Ultrasonography

Topics: Adult; Aged; Animals; Apoptosis; Arterial Pressure; Bone Morphogenetic Protein Receptors, Type II; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Glycation End Products, Advanced; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR gamma; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA Interference; S100 Proteins; Signal Transduction; STAT3 Transcription Factor; Transfection; Up-Regulation

Topics: Animals; Apoptosis; Blood Pressure; Dehydroepiandrosterone; Fibrosis; Gene Expression; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Male; NADP; NFATC Transcription Factors; Oxidative Stress; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; STAT3 Transcription Factor; Ventricular Dysfunction

Topics: Animals; Calcium Signaling; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypoxia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Pulmonary Artery; Pyrroles; Serotonin; Sulfonamides; Time Factors; TRPV Cation Channels; Vasoconstriction; Vasoconstrictor Agents

Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Endothelium, Vascular; Familial Primary Pulmonary Hypertension; Female; Hypertension, Pulmonary; Hypoxia; Indoles; Lac Operon; Male; Mice; Mice, Transgenic; Phenotype; Protein Serine-Threonine Kinases; Pulmonary Circulation; Pyrroles; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Receptors, Vascular Endothelial Growth Factor; Scleroderma, Systemic; Signal Transduction; Transforming Growth Factor beta

Topics: Animals; Arterial Pressure; Blood Gas Analysis; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Data Interpretation, Statistical; Enzyme Inhibitors; Hypoglossal Nerve; Hypoxia; Injections, Spinal; Long-Term Potentiation; Male; NADPH Oxidases; Phenols; Phrenic Nerve; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, G-Protein-Coupled; Receptors, Serotonin; Serotonin Antagonists; Spinal Cord; Sulfonamides

Topics: Animals; Antibodies, Monoclonal; Bone Morphogenetic Proteins; Chronic Disease; Familial Primary Pulmonary Hypertension; Heart Ventricles; HEK293 Cells; Hemodynamics; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Intercellular Signaling Peptides and Proteins; Lung; Mice; Pyrroles; Signal Transduction

Topics: Angiogenesis Inhibitors; Animals; Blood Pressure; Chronic Disease; Collagen; Elastic Modulus; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Proteoglycans; Pyrroles; Stress, Mechanical; Vascular Stiffness; Ventricular Dysfunction, Right; Viscosity

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiogenesis Inhibitors; Animals; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents

Topics: Animals; Atorvastatin; Blotting, Western; Heptanoic Acids; Hypertension, Pulmonary; Hypoxia; Male; NF-kappa B; Pyrroles; Random Allocation; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction

Topics: Animals; Atorvastatin; Cardiomegaly; Cytokines; Heart; Heptanoic Acids; Hypoxia; Male; Myeloid Differentiation Factor 88; Myocardium; Oxidative Stress; Pyrroles; Rats; Rats, Wistar; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Sleep Apnea, Obstructive; Toll-Like Receptor 4; Ventricular Remodeling

Topics: Acetophenones; Benzopyrans; Cell Proliferation; Cells, Cultured; Endothelial Cells; Gene Expression; Glucose; Humans; Hypoxia; Indoles; Primary Cell Culture; Protein Kinase C-delta; Protein Transport; Pyrroles; Retinal Pigment Epithelium

Topics: Animals; Apoptosis; CD4-Positive T-Lymphocytes; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Inflammation; Interleukin-6; Leukocyte Common Antigens; Lung; NF-kappa B; Pulmonary Artery; Pyrroles; Pyrrolidines; Rats; Signal Transduction; Thiocarbamates; Time Factors

Topics: Adult; Animals; Arginine; Cell Proliferation; Epinephrine; Female; Humans; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Indoles; Lung; Male; Mice, Inbred C57BL; Monocrotaline; Myocytes, Smooth Muscle; Neuropeptide Y; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Vasoconstriction; Vasoconstrictor Agents; Young Adult

Topics: Angiogenesis Inhibitors; Animals; Circadian Rhythm; Disease Models, Animal; Disease Progression; Echocardiography; Heart Ventricles; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Lung; Male; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Systole; Telemetry; Tunica Intima; Vascular Remodeling

Topics: Animals; Arterial Pressure; Cardiotonic Agents; Compliance; Disease Models, Animal; Drug Implants; Estradiol; Estrogen Replacement Therapy; Estrogens; Female; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Mice, Inbred C57BL; Myocardial Contraction; Ovariectomy; Pulmonary Artery; Pyrroles; Stroke Volume; Time Factors; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right

Topics: Adventitia; Animals; Antihypertensive Agents; Cell Movement; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Matrix; Familial Primary Pulmonary Hypertension; Fibroblasts; HEK293 Cells; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Monocrotaline; NADPH Oxidase 4; NADPH Oxidases; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Time Factors; Transfection; Up-Regulation

Topics: AC133 Antigen; Adult; Aged; Angiogenesis Inhibitors; Animals; Antigens, CD; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Hypoxia; Indoles; MCF-7 Cells; Mice; Mice, Nude; Middle Aged; Neoplasm Transplantation; Neoplastic Cells, Circulating; Nuclear Proteins; Peptides; Pyrroles; Sunitinib; Triple Negative Breast Neoplasms; Twist-Related Protein 1

Topics: Animals; Collagen; Cyclic AMP-Dependent Protein Kinases; Echocardiography; Fibroblasts; Fibrosis; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Iloprost; Indoles; Male; Matrix Metalloproteinase 9; Microscopy, Phase-Contrast; Physical Conditioning, Animal; Procollagen; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta1; Vasodilator Agents; Ventricular Function, Right

Topics: Animals; Apelin; Arterioles; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelial Cells; Fibroblast Growth Factor 2; Hemodynamics; Histone Deacetylase Inhibitors; Hydroxamic Acids; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Intercellular Signaling Peptides and Proteins; Male; MEF2 Transcription Factors; MicroRNAs; Monocrotaline; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Transcription, Genetic

Topics: Animals; Hypertension, Pulmonary; Hypoxia; Indoles; Lipids; Liposomes; Lung; Male; MicroRNAs; Nanoparticles; Oligonucleotides; Pyrroles; Rats, Sprague-Dawley

Topics: Aged; Antineoplastic Agents; Biomarkers; Carcinoma, Renal Cell; Clinical Trials, Phase II as Topic; Cluster Analysis; Comparative Genomic Hybridization; DNA-Binding Proteins; Drug Design; Female; Gene Expression Profiling; Genotype; Humans; Hypoxia; Indoles; Kidney Neoplasms; Male; Middle Aged; Mutation; Neoplasm Metastasis; Nephrectomy; Nuclear Proteins; Pilot Projects; Protein Array Analysis; Protein Kinase Inhibitors; Pyrroles; RNA, Messenger; Sunitinib; Transcription Factors; Von Hippel-Lindau Tumor Suppressor Protein

Topics: 3' Untranslated Regions; Animals; Binding Sites; Cell Proliferation; Cells, Cultured; Endothelial Cells; Endothelin-1; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; PPAR gamma; Pulmonary Artery; Pyrroles; RNA Interference; Rosiglitazone; Signal Transduction; Thiazolidinediones; Transfection; Vascular Remodeling

Topics: Animals; Biological Transport; Fatty Acid Transport Proteins; Fatty Acids; Female; Glucose; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Lipoprotein Lipase; Oxidation-Reduction; Positron-Emission Tomography; Protein Kinase Inhibitors; Pyrroles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor

Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Pyrroles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Sprague-Dawley; Species Specificity

Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin; Up-Regulation; Ventricular Remodeling

Topics: Animals; Calcium; Cell Line; Drinking; Gadolinium; HEK293 Cells; Heme Oxygenase (Decyclizing); Humans; Hydrogen-Ion Concentration; Hypoxia; Male; Morpholines; Neurons; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sodium; Subfornical Organ; Temperature; TRPV Cation Channels; Urea

Topics: Angiogenesis Inducing Agents; Animals; Animals, Newborn; Cognition; Disease Models, Animal; Erythropoietin; Hippocampus; Hypoxia; Hypoxia-Ischemia, Brain; Indoles; Male; Pyrroles; Random Allocation; Rats, Sprague-Dawley; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; White Matter

Topics: Animals; Arterial Pressure; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Focal Adhesion Kinase 1; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Integrin alphaVbeta3; Male; Mice, Knockout; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Osteoprotegerin; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; RNA Interference; Severity of Illness Index; Signal Transduction; Transfection; Vascular Remodeling; Walk Test

Topics: Animals; Cardiomegaly; Cell Proliferation; Chronic Disease; Heart Function Tests; Hemodynamics; Hyperplasia; Hypertension, Pulmonary; Hypoxia; Indoles; Ki-67 Antigen; Lung; Male; Microspheres; Oxygen Consumption; P-Selectin; Partial Pressure; Physical Conditioning, Animal; Plasminogen Activator Inhibitor 1; Polystyrenes; Pulmonary Embolism; Pyrroles; Rats, Sprague-Dawley; Tissue Inhibitor of Metalloproteinase-1; Vascular Endothelial Growth Factor A; Ventricular Dysfunction

Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Green Fluorescent Proteins; Humans; Hypoxia; Indoles; Microscopy, Confocal; Neovascularization, Pathologic; Pyrroles; Receptors, Notch; Retinal Diseases; Retinal Neovascularization; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor A; Zebrafish

Topics: Animals; Animals, Newborn; Anticoagulants; Cell Death; Factor Xa; Fondaparinux; Gene Expression Regulation; Glucose; Hippocampus; Hypoxia; Ischemia; JNK Mitogen-Activated Protein Kinases; Organ Culture Techniques; Polysaccharides; Pyrroles; Quinazolines; Rats; Receptor, PAR-1; Serine; Signal Transduction; Thrombin

Topics: Animals; Antineoplastic Agents; Capillary Permeability; Carcinoma, Renal Cell; Contrast Media; Female; Gadolinium DTPA; Humans; Hypoxia; Immunoprecipitation; Indoles; Kidney Neoplasms; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Pyrroles; Receptors, Platelet-Derived Growth Factor; Sunitinib; Tumor Cells, Cultured; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

Topics: Animals; Animals, Newborn; Brain Injuries; Cell Survival; Cells, Cultured; Chromones; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Glial Fibrillary Acidic Protein; Glucose; Hypoxia; Hypoxia-Ischemia, Brain; Indoles; Injections, Intraventricular; Male; Morpholines; Neurons; Phosphorylation; Placenta Growth Factor; Platelet Endothelial Cell Adhesion Molecule-1; Pregnancy Proteins; Pyrroles; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction; Time Factors; Transfection; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

Topics: Angiogenesis Inhibitors; Animals; Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Cell Movement; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoenzyme Techniques; Indoles; Mice; Mice, Inbred NOD; Mice, SCID; Neovascularization, Pathologic; Neuroblastoma; Proto-Oncogene Proteins c-kit; Proto-Oncogene Proteins c-ret; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Receptors, Interleukin-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Sunitinib; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-3; Xenograft Model Antitumor Assays

Topics: Aerobiosis; Apoptosis; Cell Cycle; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Microtubules; Neoplasms; Oxazepines; Pyrroles; Radiation Tolerance; Radiation-Sensitizing Agents

Topics: Animals; Anticholesteremic Agents; Atorvastatin; Hemodynamics; Heptanoic Acids; Hypertension, Pulmonary; Hypoxia; Male; Pulmonary Artery; Pyrroles; Random Allocation; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Ventricular Remodeling

Topics: Amino Acid Sequence; Animals; Drug Delivery Systems; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Lung; Male; Molecular Sequence Data; Monocrotaline; Peptides; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; Time Factors

Topics: Animals; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Lung; Male; Natriuretic Agents; Natriuretic Peptide, C-Type; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor

Topics: Acute Disease; Animals; Blotting, Western; Cytokines; Disease Models, Animal; Echocardiography; Female; Fluorescent Antibody Technique; Gene Expression Profiling; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Indoles; Lung; Male; Mice; Mice, Inbred C57BL; Pyrroles; Receptors, Vascular Endothelial Growth Factor

Topics: Animals; Animals, Newborn; Atorvastatin; Blotting, Western; Cells, Cultured; Electrophoretic Mobility Shift Assay; Extracellular Signal-Regulated MAP Kinases; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy; Hypoxia; Myocytes, Cardiac; Nuclear Proteins; Pyrroles; Rats; Rats, Wistar; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Trans-Activators

Topics: Animals; Caspases; Cell Division; Cells, Cultured; Chelating Agents; Copper; Diet; Endothelium, Vascular; Enzyme Activation; Humans; Hypertension, Pulmonary; Hypoxia; Immunohistochemistry; Indoles; Male; Microvessels; Molybdenum; Neovascularization, Pathologic; Pyrroles; Rats; Rats, Sprague-Dawley

Topics: Animals; Apoptosis; Blood Pressure; Blotting, Western; Caspase 3; Cell Proliferation; Cyclic GMP; Guanylate Cyclase; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Immunohistochemistry; Indoles; Lung; Male; Nitric Oxide Synthase Type III; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sildenafil Citrate; Soluble Guanylyl Cyclase; Sulfones; Time Factors; Treatment Outcome

Topics: Animals; Caffeine; Calcium Channel Agonists; Calcium Signaling; Cell Hypoxia; Cells, Cultured; Dantrolene; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Macrocyclic Compounds; Male; Morpholines; Muscle Contraction; Muscle Relaxants, Central; Myocytes, Smooth Muscle; Oxazoles; Patch-Clamp Techniques; Phorbols; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Ryanodine; Ryanodine Receptor Calcium Release Channel; TRPV Cation Channels

Topics: Animals; Benzamides; Disease Models, Animal; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Imatinib Mesylate; Indoles; Mice; Mice, Knockout; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Serotonin; Tryptophan Hydroxylase

Topics: Animals; Anxiety; Behavior, Animal; Female; Hypoxia; Male; Paraventricular Hypothalamic Nucleus; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Sex Factors

Topics: Angiography; Animals; Animals, Newborn; Birth Weight; Chronic Disease; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Lung; Pulmonary Alveoli; Pulmonary Artery; Pulmonary Circulation; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Stress, Physiological

Topics: Animals; Hypoxia; Lipid Peroxidation; Male; Maze Learning; Oxidative Stress; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Sleep Apnea Syndromes; Spatial Behavior

Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Benzoates; Chloromercuribenzoates; Cysteine; Glutathione; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Hypoxia; Lung; Manometry; Oxygen; Pharmacology; Pyrroles; Research; Sulfhydryl Compounds; Sulfites; Thioglycolates

Topics: Animals; Apoptosis; Cell Survival; Hypoxia; Indoles; Microcirculation; Models, Biological; Neoplasms; Neovascularization, Pathologic; Oxindoles; Pericytes; Platelet-Derived Growth Factor; Propionates; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Blotting, Western; Butadienes; Cell Division; Cell Line, Tumor; Chromones; Deoxycytidine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gemcitabine; Humans; Hypoxia; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Pathologic; NF-kappa B; Nitriles; Oxygen; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Signal Transduction; Sp1 Transcription Factor; Time Factors; Tyrosine

Topics: Adrenalectomy; Adrenocorticotropic Hormone; Animals; Cold Temperature; Corticotropin-Releasing Hormone; Hypoxia; Immunohistochemistry; Male; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Pituitary Gland; Prolactin; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Restraint, Physical; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stress, Psychological

Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Count; Cells, Cultured; Drug Interactions; Glucose; Hippocampus; Hypoxia; Neural Cell Adhesion Molecules; Neurons; Neuroprotective Agents; Organ Culture Techniques; Phosphorylation; Propidium; Pyridinium Compounds; Pyrroles; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Fibroblast Growth Factor; Synapses; Tetrazolium Salts; Thiazoles; Time Factors

Topics: Atherosclerosis; Atorvastatin; Blotting, Western; Cells, Cultured; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypoxia; Microcirculation; Nitric Oxide Synthase Type III; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction

Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Atorvastatin; CD55 Antigens; CD59 Antigens; Cells, Cultured; Cobalt; Cytoprotection; Deferoxamine; Diterpenes; Endothelial Cells; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia; Iron Chelating Agents; Mevalonic Acid; Pyrroles; RNA, Messenger; Up-Regulation

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Disease Progression; Endothelin A Receptor Antagonists; Hypertension, Pulmonary; Hypoxia; Indoles; Intracellular Signaling Peptides and Proteins; Male; Myosin-Light-Chain Phosphatase; Organ Culture Techniques; Peptides, Cyclic; Phosphorylation; Protein Serine-Threonine Kinases; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vascular Endothelial Growth Factor Receptor-2; Vasoconstriction; Vasodilator Agents

Topics: Altitude; Animals; Blood Glucose; Body Weight; Corticosterone; Eating; Glucagon; Hypoxia; Insulin; Leptin; Liver Glycogen; Male; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone

Topics: Acute Disease; Adenine; Animals; Blood Pressure; Carbazoles; Coronary Circulation; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Glyburide; Hypoxia; In Vitro Techniques; Indoles; Male; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pyrroles; Rabbits; Signal Transduction; Thionucleotides; Vasodilation

Topics: Animals; Corticosterone; Endothelin-1; Gene Expression Regulation; Hypoxia; Male; Paraventricular Hypothalamic Nucleus; Pyrimidines; Pyrroles; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; RNA, Messenger; Time Factors

Topics: Animals; Cattle; Dogs; Hypertension, Pulmonary; Hypoxia; Monocrotaline; Pyrroles; Pyrrolizidine Alkaloids; Rabbits; Rats; Sheep; Species Specificity; Swine

Topics: Animals; Benzopyrans; Cromakalim; Cyclooxygenase Inhibitors; Ferrets; Hypoxia; Male; Nitric Oxide Synthase; Potassium Channel Blockers; Potassium Channels; Pulmonary Artery; Pyrroles; Vasodilation; Vasomotor System

Topics: Animals; Arginine; Arteries; Benzopyrans; Cerebrovascular Circulation; Cromakalim; Glyburide; Hypercapnia; Hypoxia; Nitric Oxide Synthase; omega-N-Methylarginine; Pyrroles; Rats; Theophylline; Vasodilator Agents

Topics: Animals; Benzopyrans; Cardiac Pacing, Artificial; Cromakalim; Deoxyglucose; Dose-Response Relationship, Drug; Female; Glyburide; Glycolysis; Guinea Pigs; Heart Atria; Hypoxia; In Vitro Techniques; Male; Myocardial Contraction; Parasympatholytics; Potassium Channels; Pyrroles

Topics: Aged; Animals; Benzopyrans; Calcium; Calcium Channels; Cromakalim; Glyburide; Humans; Hypoxia; In Vitro Techniques; Iodoacetates; Iodoacetic Acid; Male; Middle Aged; Muscle, Smooth, Vascular; Nifedipine; Potassium Channels; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Vasoconstriction; Verapamil

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Deoxyglucose; Endothelium, Vascular; Glyburide; Glycolysis; Hypoxia; In Vitro Techniques; Indomethacin; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Swine; Theophylline; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents

Topics: Animals; Benzopyrans; Biological Assay; Coronary Vessels; Cromakalim; Glyburide; Guinea Pigs; Hypoxia; In Vitro Techniques; Muscle, Smooth, Vascular; Perfusion; Potassium Channels; Pyrroles; Vasodilator Agents

Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cardiotonic Agents; Cromakalim; Energy Metabolism; Glycogen; Guinea Pigs; Heart; Hypoxia; In Vitro Techniques; Lactates; Myocardium; Phosphocreatine; Pyrroles

Topics: Animals; Benzopyrans; Calcium; Cromakalim; Dinoprost; Endothelium, Vascular; Hypoxia; In Vitro Techniques; Male; Potassium Chloride; Pulmonary Artery; Pyrroles; Quaternary Ammonium Compounds; Rats; Vasoconstriction; Vasodilator Agents

Topics: Action Potentials; Adenosine Triphosphate; Aging; Animals; Benzopyrans; Cromakalim; Depression, Chemical; Electrophysiology; Female; Guinea Pigs; Heart; Heart Ventricles; Hypoxia; In Vitro Techniques; Kinetics; Male; Myocardial Contraction; Potassium Channels; Pregnancy; Pyrroles; Ventricular Function

Topics: Adenosine; Animals; Arginine; Benzopyrans; Blood Pressure; Cromakalim; Drug Synergism; Ear, External; Guanidines; Hypoxia; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Pinacidil; Pyrroles; Rabbits; Regional Blood Flow; Vasodilation; Vasodilator Agents; Xanthines

Topics: Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Carbachol; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hypoxia; In Vitro Techniques; Isoproterenol; Muscle Relaxation; Potassium Channels; Pyrroles; Swine

Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Drug Interactions; Glucose; Glyburide; Guinea Pigs; Heart; Hypoxia; In Vitro Techniques; Kinetics; Papillary Muscles; Phentolamine; Potassium Channels; Pyrroles

Topics: Animals; Brain; Fermentation; Hypoxia; Lipid Peroxidation; Male; Mice; Proline; Pyrroles; Rats; Rats, Wistar; Streptomyces

Topics: Acetylcholine; Animals; Arginine; Benzopyrans; Cromakalim; Ear, External; Guanidines; Hypoxia; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxidative Phosphorylation; Pinacidil; Piperazines; Pyrroles; Rabbits; Receptors, N-Methyl-D-Aspartate; Regional Blood Flow; Vasodilator Agents; Verapamil

Topics: Acute Disease; Adenosine Triphosphate; Animals; Benzopyrans; Blood Gas Analysis; Blood Pressure; Chronic Disease; Cromakalim; Glyburide; Heart Rate; Hemodynamics; Hypoglycemic Agents; Hypoxia; Male; Phenylephrine; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vascular Resistance; Vasoconstrictor Agents

Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hippocampus; Hypoxia; Male; Mice; Pyrroles; Thiazoles

Topics: Acute Disease; Amlodipine; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Endothelium, Vascular; Hypoxia; In Vitro Techniques; Male; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Vasoconstriction; Vasodilator Agents

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Cromakalim; Drug Interactions; Glyburide; Hypoxia; In Vitro Techniques; Male; Potassium Channel Blockers; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Thromboxane A2; Vasoconstrictor Agents

Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Female; Guinea Pigs; Heart; Heart Ventricles; Hypoxia; Male; Methoxamine; Niacinamide; Nicorandil; Papillary Muscles; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Ventricular Function

Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Endothelium, Vascular; Glyburide; Hypoglycemia; Hypoxia; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents

Topics: Acetylcholine; Animals; Benzopyrans; Bradykinin; Calcium; Cattle; Coronary Vessels; Cromakalim; Endothelium, Vascular; Glyburide; Hypoxia; In Vitro Techniques; Membrane Potentials; Microelectrodes; Microscopy, Video; Oxygen; Perfusion; Pyrroles; Vascular Resistance; Vasodilation; Vasodilator Agents

Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Arterioles; Benzimidazoles; Benzopyrans; Cerebral Arteries; Cromakalim; Cyclic GMP; Female; Hypoxia; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Penicillamine; Pia Mater; Potassium Channels; Pyrroles; S-Nitroso-N-Acetylpenicillamine; Swine; Vasodilation; Vasodilator Agents

Topics: Adenosine Triphosphate; Animals; Arteries; Benzopyrans; Blood Pressure; Capillaries; Cromakalim; Dogs; Female; Hypoxia; Male; Potassium Channels; Pulmonary Circulation; Pyrroles; Serotonin; Serotonin Antagonists; Vascular Resistance; Vasoconstrictor Agents; Vasodilator Agents; Veins

Topics: Amino Acid Sequence; Amnesia; Animals; Antidepressive Agents; Azocines; Electroencephalography; Hypoxia; Magnetic Resonance Spectroscopy; Mice; Molecular Sequence Data; Protein Conformation; Pyrazines; Pyrroles; Rats; Thyrotropin-Releasing Hormone

Topics: Animals; Blood Pressure; Enzyme Inhibitors; Heart Rate; Hypercapnia; Hypoxia; Indoles; Male; Neocortex; Protein Kinase C; Pulmonary Ventilation; Pyrroles; Rats; Rats, Sprague-Dawley

Topics: Age Factors; Animals; Battered Child Syndrome; Body Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Free Radical Scavengers; Glutamic Acid; Head Injuries, Closed; Humans; Hypoxia; Infant; Lipid Peroxidation; Male; Nerve Degeneration; Neuroprotective Agents; Pregnatrienes; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Riluzole; Time Factors

Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Blood Pressure; Caspase 3; Caspases; Cell Death; Cell Division; Endothelium, Vascular; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Muscle, Smooth, Vascular; Myocardium; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor

Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Glyburide; Hypoxia; In Vitro Techniques; Lung; Male; Potassium Channels; Pyrroles; Rats; Tolbutamide; Vasoconstriction

Topics: Angiotensin II; Animals; Benzopyrans; Cromakalim; Guanidines; Hypoxia; In Vitro Techniques; Pinacidil; Potassium Channels; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilator Agents

Topics: Animals; Aorta; Benzopyrans; Biological Assay; Biological Factors; Cromakalim; Epithelium; Glyburide; Guinea Pigs; Hypoxia; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Pyrroles; Rats; Rats, Inbred Strains; Respiratory Physiological Phenomena

Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Glyburide; Hypoxia; In Vitro Techniques; Male; Potassium Channels; Pyrroles; Rabbits; Vasodilation; Vasodilator Agents

Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Glucose; Guanidines; Hypoxia; Permeability; Pinacidil; Portal Vein; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes

Topics: Animals; Aziridines; Cell Line; Cell Survival; Cricetinae; Cricetulus; Cytotoxins; Free Radicals; Hypoxia; In Vitro Techniques; Magnetic Resonance Spectroscopy; Nitro Compounds; Polarography; Pyrazoles; Pyrroles; Radiation-Sensitizing Agents

Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Ferrets; Glucose; Glyburide; Hypoxia; In Vitro Techniques; Lung; Male; Oxygen; Potassium Channels; Pyrroles; Vasoconstriction; Vasodilator Agents

Topics: Animals; Benzopyrans; Cromakalim; Dogs; Hemodynamics; Hypoxia; Infusions, Intravenous; Lung; Pulmonary Circulation; Pyrroles; Time Factors; Vasodilator Agents

Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Bradykinin; Coronary Vessels; Cromakalim; Endothelium, Vascular; Glyburide; Guinea Pigs; Hypoxia; In Vitro Techniques; Ischemia; Potassium Channels; Pyrroles; Vasodilation

Topics: Animals; Benzopyrans; Cromakalim; Endothelium, Vascular; Glyburide; Hypoxia; In Vitro Techniques; Male; Mesenteric Arteries; Potassium; Pulmonary Artery; Pyrroles; Rats; Rats, Inbred Strains; Rest; Vasoconstriction; Vasodilator Agents; Verapamil

Topics: Action Potentials; Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Electrophysiology; Ferrets; Glyburide; Guinea Pigs; Heart; Hypoxia; Ion Channels; Myocardium; Potassium; Pyrroles