pyrroles has been researched along with Alloxan Diabetes in 97 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (6.19) | 18.7374 |
| 1990's | 18 (18.56) | 18.2507 |
| 2000's | 25 (25.77) | 29.6817 |
| 2010's | 41 (42.27) | 24.3611 |
| 2020's | 7 (7.22) | 2.80 |
| Authors | Studies |
|---|---|
| El Medany, AMH; Ghazala, RA; Hammadi, SHM; Khalifa, HM; Zakaria Mohammed, HS | 1 |
| Alarifi, S; Gautam, N; Mohseen, M; Pal, AK; Palanivel, H; Prabhu, SV; Saxena, M | 1 |
| Gao, L; Li, R; Li, Y; Lu, W; Peng, M; Qiu, C; Shan, Y; Wang, X; Zheng, X | 1 |
| Bako, HY; Ibrahim, MA; Ibrahim, S; Isah, MS | 1 |
| Abe, M; Endo, M; Fukuda, N; Horikoshi, S; Okamura, M; Otsuki, M; Tsunemi, A | 1 |
| Cheng, Q; Jia, X; Sheng, D; Wu, J; Xiao, C; Yang, M; Zhang, S | 1 |
| Han, Y; Li, Y; Sun, P; Xu, N | 1 |
| Kanasaki, K; Koya, D; Kumagai, A; Liu, H; Takagaki, Y | 1 |
| Jain, M; Joharapurkar, A; Kshirsagar, S; Patel, MS; Patel, V; Savsani, H | 1 |
| Acikgoz, E; Aktug, H; Demir, K; Duzagac, F; Guven, U; Oktem, G; Oltulu, F; Yavasoglu, A; Yigitturk, G | 1 |
| Cho, S; Kim, E; Park, KW; Yang, J | 1 |
| Bell, A; Clapper, W; Gunnet, J; Haug, P; Hua, H; Huebert, N; Jenkinson, C; Koudriakova, T; Leonard, J; Murray, WV; Suckow, A; Sui, Z; Wall, M; Wang, Y; Winters, MP; Yan, W | 1 |
| Dong, P; Wang, YH; Wu, JJ; Zhang, M; Zhu, XN | 1 |
| Abd-El Hameed, RH; Fatahala, SS; Mahgub, S; Taha, H | 1 |
| Feng, B; Li, X; Wang, H; Xu, L | 1 |
| Alizadeh-Fanalou, S; Amniattalab, A; Hassani-Dizaj, S; Malekinejad, H; Rezabakhsh, A; Rokhsartalab-Azar, S | 1 |
| Cai, W; Cao, Y; Chen, X; Li, S; Ma, W; Su, J; Wang, F; Zou, W | 1 |
| Aslam, M; Bhattacharya, SK; Galav, V; Jafri, AA; Madhu, SV | 1 |
| Casiano, H; Crespo, MJ; Cruz, N; Hernandez, C; Quidgley, J; Rivera, K; Torres, H | 1 |
| Chang, CY; Chang, KC; Chang, RW; Chen, YS; Ko, WJ; Ko, YH; Tsai, PR; Wang, CH; Wang, SS; Young, TH | 1 |
| Chaudagar, KK; Mehta, AA | 1 |
| Akdemir, A; Aktug, H; Erbas, O; Ergenoglu, M; Taskiran, D; Yavasoglu, A; Yildirim, N; Zeybek, B | 1 |
| Deng, T; Li, H; Li, Y; Tian, L; Zhao, P; Zhou, S | 1 |
| Abdelaziz, DH; Ali, SA; Fathallah, SS; Mohamed, MS | 1 |
| Grabowski, T; Grześkowiak, E; Karbownik, A; Lewandowska, M; Matuszewski, M; Połom, W; Sobańska, K; Szałek, E; Wolc, A | 1 |
| Bento, CF; Fernandes, R; Matafome, P; Pereira, P; Seiça, RM; Sena, CM | 1 |
| Akman, L; Akman, T; Aktug, H; Artunc Ulkumen, B; Erbas, O; Oltulu, F; Pala, EE; Pala, HG; Yavasoglu, A | 1 |
| Brown, CE; Gerrow, K; Holmes, A; Lockhart, KL; Nahirney, PC; Reeson, P; Tennant, KA; Thompson, K; Wang, J; Weiser Novak, S | 1 |
| Han, SH; Kang, HY; Kang, SW; Kim, CH; Kim, S; Lee, MJ; Lee, SH; Moon, SJ; Nam, BY; Oh, HJ; Paeng, J; Park, JT; Yoo, TH | 1 |
| Du, M; Guo, F; Huang, F; Li, W; Ma, X; Qin, G; Wang, H; Wang, Q; Wu, L; Zhao, S | 1 |
| Chen, XM; Field, MJ; Kelly, DJ; Mangiafico, S; Mather, A; McGinn, S; Pollock, CA; Sumual, S; Zhang, Y | 1 |
| Amaral, C; Cipriano, A; Crisóstomo, J; Louro, T; Matafome, P; Moedas, AR; Monteiro, P; Nunes, E; Rodrigues, L; Seiça, R | 1 |
| Bantly, A; Hamamdzic, D; Mohler, ER; Moore, J; Parmacek, M; Putt, M; Rader, DJ; Shi, Y; Wilensky, RL; Yoder, M; Zhang, L | 1 |
| Chavalmane, AK; Fibbi, B; Filippi, S; Forti, G; Maggi, M; Morelli, A; Sarchielli, E; Silvestrini, E; Vannelli, GB; Vignozzi, L; Zhang, XH | 1 |
| Boyle, A; Connelly, KA; Gilbert, RE; Kelly, D; Kompa, A; Krum, H; Martin, JH; Zhang, Y | 1 |
| Abe, T; Kakehashi, A; Matsushita, M; Miyajima, K; Morinaga, H; Ohta, T; Sasase, T; Shinohara, M | 1 |
| Cayc, MK; Erbilen, E; Gulcan, E; Olgun, EG; Ozay, Y; Toker, S | 1 |
| Chen, L; Ding, G; Jia, R; Tu, Y | 1 |
| Bijjem, KV; Goyal, S; Kumar, S; Singh, M | 1 |
| Arany, EJ; Hill, DJ; Marchand, KC | 1 |
| Barut, T; Ekerbiçer, N; Gürpınar, T; Harzadın, NU; Tarakçı, F; Tuglu, MI | 1 |
| Sharma, PL; Sharma, S; Singh, M | 1 |
| Bando, YK; Monji, A; Morimoto, Y; Murohara, T; Shigeta, T | 1 |
| Gade, J; Neerati, P | 1 |
| Amaral, C; Cipriano, A; Crisóstomo, J; Louro, T; Matafome, P; Monteiro, P; Nunes, E; Rodrigues, L; Seiça, R | 1 |
| Advani, A; Cox, AJ; Gilbert, RE; Kelly, DJ; Wiggins, KJ; Zhang, Y | 1 |
| Bromberg, JS; Ding, Y; Shi, Q; Xu, J; Yin, N; Zhang, N | 1 |
| Ahmed, D; Pillai, KK; Sharma, M | 1 |
| Chen, QJ; Lu, L; Peng, WH; Shen, WF; Wang, LJ; Wang, W | 1 |
| Huang, YJ; Li, Y; Wang, S | 1 |
| Reddy, PJ; Sekhar, MC | 1 |
| Carpenter, AJ; Chandrasekar, B; Das, NA; Delafontaine, JL; Siebenlist, U; Valente, AJ; Venkatesan, B; Yoshida, T | 1 |
| Cao, Y; Fan, Y; Huang, Y; Yang, S; Zhang, X | 1 |
| Bidasee, KR; Kutty, S; Moore, CJ; Nagai, R; Shao, CH; Singh, J | 1 |
| Dixon, JL; Shen, S; Sturek, M; Sun, GY; Vuchetich, JP; Wysocka, E | 1 |
| Besch, HR; Bidasee, KR; Dincer, UD; Nallani, K | 1 |
| LAHIRI, SC; PATHAK, B | 1 |
| Ichihara, K; Kanda, M; Satoh, K | 1 |
| Agarwal, N; Dixit, M; Goel, A; Maulik, PR; Pratap, R; Ram, VJ; Sharon, A; Singh, FV; Srivastava, AK; Tiwari, P | 1 |
| Chakrabarti, S; Cukiernik, M; Downey, D; Evans, T; Hileeto, D; Mukherjee, S | 1 |
| Gilbert, RE; Kelly, DJ; Wassef, L | 1 |
| Kakuta, H; Kihara, R; Shimano, H; Suzuki, M; Tada-Iida, K; Takahashi, A; Yamada, N; Yokoo, T | 1 |
| Kummerow, FA; Mahfouz, MM | 1 |
| Abe, T; Imagawa, N; Ito, M; Matsushita, M; Sagawa, S; Sakoda, K; Sasase, T; Tanaka, M; Yamada, H | 1 |
| Brumeanu, TD; Casares, S; Goldstein, R | 1 |
| Abraham, NG; Bolognesi, M; Di Pascoli, M; Rodella, L; Sacerdoti, D; Turkseven, S | 1 |
| Shah, DI; Singh, M | 1 |
| Dhayat, N; Dhayat, S; Du, J; Hilfiker-Kleiner, D; Laufs, U; Noutsias, M; Riad, A; Schultheiss, HP; Spillmann, F; Tschöpe, C; Van Linthout, S; Westermann, D | 1 |
| Chen, P; Edwards, PA; Guo, AM; Scicli, AG; Trick, G | 1 |
| Adams, V; Doehner, W; Du, J; Mohr, Z; Pauschinger, M; Riad, A; Schultheiss, HP; Sobirey, M; Stiehl, S; Tschöpe, C; Westermann, D | 1 |
| Bauersachs, J; Brandt, M; Closs, E; Daiber, A; Ertl, G; Förstermann, U; Münzel, T; Oelze, M; Thum, T; Wenzel, P; Xu, J; Zou, MH | 1 |
| Kam, KL; Pfaffendorf, M; van Zwieten, PA | 1 |
| Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Narita, M; Suzuki, T | 1 |
| Igaki, N; Kasuga, M; Miyata, S; Miyauchi, Y; Ohara, T; Oimomi, M; Sakai, M; Shoda, H; Yamada, H; Yatabe, H | 1 |
| Mayhan, WG | 1 |
| Das, DK; Engelman, DT; Engelman, RM; Tosaki, A | 1 |
| Angel, I; Burcelin, R; Girard, J; Langer, SZ; Prouteau, M | 1 |
| Das, DK; Engelman, RM; Tosaki, A | 1 |
| Elgawish, AH; Friedlander, MA; Glomb, M; Monnier, VM; Nagaraj, RH; Portero-Otin, M; Sell, DR | 1 |
| Kasuga, M; Liu, BF; Miyata, S; Ohara, T; Oimomi, M; Shoda, H; Suzuki, K; Yamada, H | 1 |
| Anthony, DM; Buckett, WR; Dickinson, K; Jones, RB; Kaul, CL; Marita, AR | 1 |
| Das, DK; Tosaki, A | 1 |
| Kamato, T; Miyata, K; Nagakura, Y; Yamano, M | 1 |
| Angel, I; Coste, A; Eon, MT; Guillot, E | 1 |
| Kamei, J; Ohsawa, M | 1 |
| Kasuga, M; Kojima, H; Kusunoki, H; Liu, BF; Miyata, S; Suzuki, K; Uriuhara, A | 1 |
| Rauscher, FM; Sanders, RA; Watkins, JB | 1 |
| Gajdosik, A; Gajdosikova, A; Krizanova, L; Stefek, M | 1 |
| Dixon, JL; Hill, BJ; Sturek, M | 1 |
| Kamata, K; Kasuya, Y; Miyata, N; Otomo, S; Tsuchida, K; Yamaura, H | 1 |
| Honoré, E; Lazdunski, M | 1 |
| Hirata, Y; Okada, K | 1 |
| Kamata, K; Kasuya, Y; Miyata, N | 1 |
| Fujimori, S; Hirata, Y; Okada, K | 1 |
| Fujimori, S; Hirata, Y; Okada, K; Segawa, M | 1 |
| Duhault, J; Lebon, F | 1 |
| Fang, VS | 1 |
2 review(s) available for pyrroles and Alloxan Diabetes
| Article | Year |
|---|---|
Down-regulation of autoreactive T-cells by HMG CoA reductase inhibitors.
Topics: Animals; Antigen-Presenting Cells; Atorvastatin; Autoimmune Diseases; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Down-Regulation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pyrroles; T-Lymphocytes | 2006 |
Structure of advanced Maillard reaction products and their pathological role.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Glycation End Products, Advanced; Humans; Kidney Failure, Chronic; Lens, Crystalline; Maillard Reaction; Molecular Structure; Norleucine; Peritoneal Dialysis; Pyrroles; Renal Dialysis | 1996 |
95 other study(ies) available for pyrroles and Alloxan Diabetes
| Article | Year |
|---|---|
The vascular impact of dapagliflozin, liraglutide, and atorvastatin alone or in combinations in type 2 diabetic rat model.
Topics: Animals; Atorvastatin; Benzhydryl Compounds; C-Reactive Protein; Cholesterol, LDL; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucosides; Glycated Hemoglobin; Liraglutide; Male; Pyrroles; Rats; Thyrotropin | 2022 |
Antidiabetic Effect of
Topics: Adipocytes; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Down-Regulation; Gene Expression; Glucose; Hypoglycemic Agents; Inflammation; Lipoproteins, LDL; Momordica charantia; Phenylpropionates; Plant Extracts; Pyrroles; Tamarindus | 2022 |
Cathelicidin-related antimicrobial peptide protects against cardiac fibrosis in diabetic mice heart by regulating endothelial-mesenchymal transition.
Topics: AMP-Activated Protein Kinases; Animals; Antimicrobial Cationic Peptides; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Echocardiography; Endothelial Cells; Endothelium; Epithelial-Mesenchymal Transition; Fibrosis; Glucose; Hemodynamics; Hyperglycemia; Male; Mice; Mice, Inbred C57BL; Pyrazoles; Pyrroles; Signal Transduction; Transforming Growth Factor beta | 2019 |
Inhibition of JAK-STAT and NF-κB signalling systems could be a novel therapeutic target against insulin resistance and type 2 diabetes.
Topics: Animals; Aspirin; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Interleukin-6; Janus Kinases; Male; NF-kappa B; Piperidines; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Serum Amyloid A Protein; Signal Transduction; STAT Transcription Factors; Tumor Necrosis Factor-alpha | 2019 |
Contribution of TGF-β1 and Effects of Gene Silencer Pyrrole-Imidazole Polyamides Targeting TGF-β1 in Diabetic Nephropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Gene Silencing; Imidazoles; Male; Nylons; Pyrroles; Rats; Rats, Wistar; Transforming Growth Factor beta1 | 2020 |
TRPV4 Mediates Cardiac Fibrosis via the TGF-β1/Smad3 Signaling Pathway in Diabetic Rats.
Topics: Animals; Cell Proliferation; Cells, Cultured; Collagen Type I; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Fibroblasts; Fibrosis; Male; Morpholines; Myocardium; Phosphorylation; Pyrroles; Rats, Sprague-Dawley; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1; TRPV Cation Channels | 2020 |
Destruction of the blood-retina barrier in diabetic retinopathy depends on angiotensin-converting enzyme-mediated TGF-β1/Smad signaling pathway activation.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cells, Cultured; Coculture Techniques; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelial Cells; Ependymoglial Cells; Fosinopril; Male; Peptidyl-Dipeptidase A; Pyrazoles; Pyrroles; Rats; Rats, Sprague-Dawley; Retina; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1 | 2020 |
The PKM2 activator TEPP-46 suppresses kidney fibrosis via inhibition of the EMT program and aberrant glycolysis associated with suppression of HIF-1α accumulation.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Epithelial-Mesenchymal Transition; Fibrosis; Glycolysis; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Mice; Oxidative Phosphorylation; Pyridazines; Pyrroles; Pyruvate Kinase; Streptozocin | 2021 |
Effect of dual PPAR-α/γ agonist saroglitazar on diabetic retinopathy and oxygen-induced retinopathy.
Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Chick Embryo; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Female; Hyperoxia; Intercellular Adhesion Molecule-1; Male; Neovascularization, Physiologic; Oxidative Stress; Phenylpropionates; PPAR alpha; PPAR gamma; Pyrroles; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; Retina; Retinal Neovascularization; Retinal Vessels; Signal Transduction; Streptozocin; Transcription Factor RelA | 2021 |
Repression of the Notch pathway prevents liver damage in streptozotocin-induced diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Down-Regulation; Immunohistochemistry; Indoles; Jagged-1 Protein; Liver; Liver Diseases; Male; Mice; Pyrroles; Receptor, Notch1; Signal Transduction; Sunitinib | 2017 |
Inhibition of VEGF Signaling Reduces Diabetes-Exacerbated Brain Swelling, but Not Infarct Size, in Large Cerebral Infarction in Mice.
Topics: Animals; Blood Glucose; Brain Edema; Brain Ischemia; Cerebral Infarction; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucose Tolerance Test; Indoles; Insulin; Male; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; Proteoglycans; Pyrroles; RNA, Messenger; Signal Transduction; Stroke; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2018 |
Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Discovery; Humans; Hypoglycemic Agents; Mice; Molecular Structure; Pyrroles; Receptors, G-Protein-Coupled; Structure-Activity Relationship | 2018 |
[Correlation between expressions of VEGF and TRPC6 and their roles in podocyte injury in rats with diabetic nephropathy].
Topics: Animals; Chromones; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Indoles; Kidney; Membrane Proteins; Morpholines; Podocytes; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; TRPC Cation Channels; Vascular Endothelial Growth Factor A | 2018 |
Synthesis and evaluation of novel spiro derivatives for pyrrolopyrimidines as anti-hyperglycemia promising compounds.
Topics: Animals; Blood Glucose; Cyclization; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Hypoglycemic Agents; Male; Proton Magnetic Resonance Spectroscopy; Pyrimidines; Pyrroles; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spiro Compounds; Streptozocin | 2018 |
Multiple statistical methods for assessing differential gene expression in microarray data of diabetic model rats to predict the molecular mechanism of atorvastatin on anti-atherogenesis.
Topics: Animals; Anticholesteremic Agents; Atherosclerosis; Atorvastatin; Data Interpretation, Statistical; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Gene Expression Profiling; Heptanoic Acids; Male; Microarray Analysis; Prognosis; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Streptozocin; Treatment Outcome | 2013 |
Effects of silymarin on the pharmacokinetics of atorvastatin in diabetic rats.
Topics: Animals; Atorvastatin; Cytochrome P-450 CYP3A; Diabetes Mellitus, Experimental; Drug Interactions; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Male; Pyrroles; Rats; Rats, Wistar; Silymarin; Streptozocin; Testosterone | 2014 |
Atorvastatin ameliorates contrast medium-induced renal tubular cell apoptosis in diabetic rats via suppression of Rho-kinase pathway.
Topics: Acute Kidney Injury; Animals; Apoptosis; Atorvastatin; bcl-2-Associated X Protein; Caspase 3; Contrast Media; Diabetes Mellitus, Experimental; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Iohexol; Kidney Tubules; Male; Protein Phosphatase 1; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Rats; Rats, Wistar; rho-Associated Kinases | 2014 |
Atorvastatin prevents type 2 diabetes mellitus--an experimental study.
Topics: Animals; Atorvastatin; Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Insulin Resistance; Lipid Metabolism; Male; Pyrroles; Rats; Rats, Wistar; Triglycerides | 2014 |
Daily administration of atorvastatin and simvastatin for one week improves cardiac function in type 1 diabetic rats.
Topics: Animals; Atorvastatin; Blood Glucose; Cardiac Output; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Administration Schedule; Heart; Heart Rate; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pravastatin; Pyrroles; Rats; Rats, Sprague-Dawley; Simvastatin; Ventricular Function, Left | 2014 |
Prevention of arterial stiffening by using low-dose atorvastatin in diabetes is associated with decreased malondialdehyde.
Topics: Animals; Arginine; Atorvastatin; Blood Glucose; Blood Pressure; Body Weight; C-Reactive Protein; Cholesterol; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Fatty Acids; Glycation End Products, Advanced; Hemodynamics; Heptanoic Acids; Lysine; Male; Malondialdehyde; Organ Size; Pyrroles; Rats, Wistar; Streptozocin; Vascular Stiffness | 2014 |
Effect of atorvastatin on the angiogenic responsiveness of coronary endothelial cells in normal and streptozotocin (STZ) induced diabetic rats.
Topics: Androstadienes; Animals; Anticholesteremic Agents; Atorvastatin; Benzophenanthridines; Chick Embryo; Chorioallantoic Membrane; Coronary Vessels; Diabetes Mellitus, Experimental; Endothelial Cells; Enzyme Inhibitors; Heptanoic Acids; Male; Myocardial Reperfusion Injury; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pyrroles; Rats; Rats, Wistar; Streptozocin; Vascular Endothelial Growth Factor A; Wortmannin | 2014 |
High-dose atorvastatin ameliorates the uterine microenvironment in streptozotocin-induced diabetic rats.
Topics: Animals; Atorvastatin; Diabetes Mellitus, Experimental; Endometrium; ErbB Receptors; Female; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Uterus; Vascular Endothelial Growth Factor A | 2014 |
Renoprotective effect of atorvastatin on STZ-diabetic rats through attenuating kidney-associated dysmetabolism.
Topics: Animals; Atorvastatin; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Insulin; Kidney; Lipoproteins, HDL; Lipoproteins, LDL; Male; Proteinuria; Pyrroles; Rats, Sprague-Dawley; RNA, Messenger; Streptozocin; Transforming Growth Factor beta1 | 2014 |
Synthesis and evaluation of novel pyrroles and pyrrolopyrimidines as anti-hyperglycemic agents.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Design; Hyperglycemia; Hypoglycemic Agents; Magnetic Resonance Spectroscopy; Male; Models, Chemical; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Structure-Activity Relationship; Sucrose; Sulfonylurea Compounds; Temperature | 2014 |
The pharmacokinetics and hypoglycaemic effect of sunitinib in the diabetic rabbits.
Topics: Administration, Oral; Animals; Area Under Curve; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Hyperglycemia; Hypoglycemic Agents; Indoles; Male; Protein Kinase Inhibitors; Pyrroles; Rabbits; Sunitinib | 2014 |
Atorvastatin-mediated protection of the retina in a model of diabetes with hyperlipidemia.
Topics: Animals; Antioxidants; Atorvastatin; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Diet, Atherogenic; Heptanoic Acids; Hyperlipidemias; Insulin Resistance; Lipid Metabolism; Male; Oxidative Stress; Proteasome Endopeptidase Complex; Pyrroles; Rats; Reactive Oxygen Species; Retina; Ubiquitin | 2014 |
Therapeutic effect of sunitinib on diabetes mellitus related ovarian injury: an experimental rat model study.
Topics: Angiogenesis Inhibitors; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Fibrosis; Immunohistochemistry; Indoles; NF-kappa B; Ovary; Primary Ovarian Insufficiency; Pyrroles; Rats; Sunitinib | 2015 |
Delayed inhibition of VEGF signaling after stroke attenuates blood-brain barrier breakdown and improves functional recovery in a comorbidity-dependent manner.
Topics: Animals; Blood-Brain Barrier; Brain; Capillaries; Dendritic Spines; Diabetes Mellitus, Experimental; Disease Models, Animal; Endothelial Cells; Gene Expression; Indoles; Infarction; Insulin; Mice; Permeability; Pyrroles; Recovery of Function; Signal Transduction; Stroke; Synapses; Transcytosis; Vascular Endothelial Growth Factor Receptor-2 | 2015 |
Podocyte hypertrophy precedes apoptosis under experimental diabetic conditions.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Aspartic Acid; Caspase 3; Caspase Inhibitors; Cells, Cultured; Diabetes Mellitus, Experimental; ErbB Receptors; Gene Expression; Hypertrophy; Kidney Glomerulus; Male; Mice; Podocytes; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Streptozocin | 2015 |
Overexpression of FOXO1 ameliorates the podocyte epithelial-mesenchymal transition induced by high glucose in vitro and in vivo.
Topics: Animals; Azo Compounds; Desmin; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Epithelial-Mesenchymal Transition; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation; Glucose; Isoquinolines; Male; Membrane Proteins; Mice; Podocytes; Protein Serine-Threonine Kinases; Pyrazoles; Pyridines; Pyrroles; Smad3 Protein; Transforming Growth Factor beta1 | 2016 |
High glucose induced endothelial cell growth inhibition is associated with an increase in TGFbeta1 secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway.
Topics: Animals; Atorvastatin; Cell Proliferation; Diabetes Mellitus, Experimental; Down-Regulation; Endothelial Cells; Glucose; Heptanoic Acids; Humans; Kidney; Male; Mevalonic Acid; Oncogene Protein p21(ras); Oncogene Protein v-akt; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Prenylation; Pyrroles; Rats; Signal Transduction; Transforming Growth Factor beta1; Umbilical Veins | 2009 |
A role for atorvastatin and insulin combination in protecting from liver injury in a model of type 2 diabetes with hyperlipidemia.
Topics: Administration, Oral; Animals; Anticholesteremic Agents; Atorvastatin; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Drug Therapy, Combination; Fatty Liver; Heptanoic Acids; Hyperlipidemias; Hypoglycemic Agents; Injections, Subcutaneous; Insulin; Insulin Resistance; Lipids; Oxidative Stress; Pyrroles; Rats; Rats, Inbred Strains | 2009 |
Diabetes reduces bone marrow and circulating porcine endothelial progenitor cells, an effect ameliorated by atorvastatin and independent of cholesterol.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Antibiotics, Antineoplastic; Anticholesteremic Agents; Atorvastatin; Azetidines; Bone Marrow Cells; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Endothelial Cells; Ezetimibe; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pyrroles; Stem Cells; Swine; Vasodilation | 2009 |
Atorvastatin ameliorates sildenafil-induced penile erections in experimental diabetes by inhibiting diabetes-induced RhoA/Rho-kinase signaling hyperactivation.
Topics: Animals; Atorvastatin; Diabetes Mellitus, Experimental; Disease Models, Animal; Electric Stimulation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Penile Erection; Phosphodiesterase Inhibitors; Phosphorylation; Piperazines; Purines; Pyrroles; Rabbits; rho-Associated Kinases; Signal Transduction; Sildenafil Citrate; Sulfones | 2009 |
Effect of atorvastatin on cardiac remodelling and mortality in rats following hyperglycemia and myocardial infarction.
Topics: Animals; Atorvastatin; Body Weight; Cardiac Volume; Collagen Type I; Collagen Type III; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Myocardial Infarction; Myocardium; Pyrroles; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2010 |
Protein kinase C beta inhibitor prevents diabetic peripheral neuropathy, but not histopathological abnormalities of retina in Spontaneously Diabetic Torii rat.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Indans; Male; Neural Conduction; Protein Kinase C; Protein Kinase C beta; Pyrroles; Rats | 2009 |
Topical atorvastatin in the treatment of diabetic wounds.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Diabetes Mellitus, Experimental; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pyrroles; Rats; Rats, Wistar; Wound Healing; Wounds and Injuries | 2009 |
Effect of atorvastatin on dendritic cells of tubulointerstitium in diabetic rats.
Topics: Animals; Anti-Inflammatory Agents; Atorvastatin; Cell Movement; Dendritic Cells; Diabetes Mellitus, Experimental; Disease Models, Animal; Heptanoic Acids; Nephritis, Interstitial; P-Selectin; Pyrroles; Rats | 2010 |
Role of glucagon-like peptide- 1 in vascular endothelial dysfunction.
Topics: Animals; Atorvastatin; Diabetes Mellitus, Experimental; Endothelium, Vascular; Exenatide; Female; Glucagon-Like Peptide 1; Heptanoic Acids; Hyperhomocysteinemia; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Peptides; Pyrroles; Rats; Rats, Wistar; Venoms | 2010 |
Effects of atorvastatin on the regeneration of pancreatic {beta}-cells after streptozotocin treatment in the neonatal rodent.
Topics: Animals; Animals, Newborn; Atorvastatin; Body Weight; Diabetes Mellitus, Experimental; Female; Glucose Tolerance Test; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Insulin; Insulin-Secreting Cells; Male; Neovascularization, Physiologic; Organ Size; Pregnancy; Pyrroles; Rats; Rats, Wistar | 2010 |
Statin treatment reduces oxidative stress-associated apoptosis of sciatic nerve in diabetes mellitus.
Topics: Animals; Apoptosis; Atorvastatin; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nitric Oxide Synthase; Oxidative Stress; Pyrroles; Rats; Rats, Wistar; Sciatic Nerve; Streptozocin; Transforming Growth Factor beta1 | 2011 |
Beneficial effect of insulin in hyperhomocysteinemia and diabetes mellitus-induced vascular endothelium dysfunction: role of phosphoinositide dependent kinase and protein kinase B.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Atorvastatin; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperhomocysteinemia; Hypoglycemic Agents; Insulin; Male; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyrroles; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Vasodilation; Vasodilator Agents | 2011 |
Atorvastatin prevents ischemic limb loss in type 2 diabetes: role of p53.
Topics: Animals; Atorvastatin; Blotting, Western; Cells, Cultured; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Extremities; Heart; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin Resistance; Ischemia; Male; Mice; Myoblasts; Peripheral Arterial Disease; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-mdm2; Pyrroles; Tumor Suppressor Protein p53; Ubiquitin; Wound Healing | 2011 |
Influence of atorvastatin on the pharmacokinetics and pharmacodynamics of glyburide in normal and diabetic rats.
Topics: Animals; Anticholesteremic Agents; Area Under Curve; Atorvastatin; Blood Glucose; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Female; Glyburide; Half-Life; Heptanoic Acids; Hypoglycemic Agents; Male; Pyrroles; Rats; Rats, Wistar | 2011 |
Metformin and atorvastatin combination further protect the liver in type 2 diabetes with hyperlipidaemia.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Body Weight; C-Reactive Protein; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Combinations; Fatty Liver; Heptanoic Acids; Hyperlipidemias; Hypoglycemic Agents; Insulin Resistance; Interleukin-6; Liver; Metformin; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Pyrroles; Rats; Rats, Inbred Strains; Tumor Necrosis Factor-alpha | 2011 |
Inhibition of the epidermal growth factor receptor preserves podocytes and attenuates albuminuria in experimental diabetic nephropathy.
Topics: Albuminuria; Animals; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Nephropathies; ErbB Receptors; Female; Hypertrophy; Kidney; Mice; Podocytes; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Transgenic; Renin; WT1 Proteins | 2011 |
Targeting lymphangiogenesis after islet transplantation prolongs islet allograft survival.
Topics: Animals; Antibodies, Monoclonal; Diabetes Mellitus, Experimental; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Immunosuppressive Agents; Indoles; Islets of Langerhans Transplantation; Lymphangiogenesis; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Propylene Glycols; Pyrroles; Sphingosine; Sunitinib; T-Lymphocytes; Transplantation Tolerance; Transplantation, Homologous; Vascular Endothelial Growth Factor Receptor-3 | 2011 |
The effects of triple vs. dual and monotherapy with rosiglitazone, glimepiride, and atorvastatin on lipid profile and glycemic control in type 2 diabetes mellitus rats.
Topics: Administration, Oral; Animals; Anticholesteremic Agents; Atorvastatin; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Synergism; Drug Therapy, Combination; Female; Glycated Hemoglobin; Heptanoic Acids; Hypolipidemic Agents; Lipids; Male; Pyrroles; Rats; Rosiglitazone; Sulfonylurea Compounds; Thiazolidinediones | 2012 |
Effects of atorvastatin on progression of diabetic nephropathy and local RAGE and soluble RAGE expressions in rats.
Topics: Animals; Atorvastatin; Blotting, Western; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Gene Expression Regulation; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; Streptozocin | 2011 |
[The effects of VEGF-R inhibitor on podocytopathy of rats with type I diabetic nephropathy].
Topics: Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Gene Expression Regulation; Indoles; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Podocytes; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; RNA, Messenger; Vascular Endothelial Growth Factor A | 2011 |
Influence of atorvastatin on the pharmacodynamic and pharmacokinetic activity of repaglinide in rats and rabbits.
Topics: Animals; Atorvastatin; Blood Glucose; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Diabetes Mellitus, Experimental; Drug Interactions; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Piperidines; Pyrroles; Rabbits; Rats | 2012 |
CIKS (Act1 or TRAF3IP2) mediates high glucose-induced endothelial dysfunction.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Adhesion; Cell Line; Cell Movement; Chemokines; Cytokines; Diabetes Mellitus, Experimental; Endothelial Cells; Gene Expression Regulation; Glucose; Humans; I-kappa B Kinase; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Monocytes; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins c-jun; Pyrroles; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Transcription Factor AP-1; Transcription Factor RelA | 2013 |
Comparison of cardioprotective efficacy resulting from a combination of atorvastatin and ischaemic post-conditioning in diabetic and non-diabetic rats.
Topics: Animals; Atorvastatin; Cardiotonic Agents; Diabetes Mellitus, Experimental; Heart; Hemodynamics; Heptanoic Acids; Ischemic Postconditioning; Male; Myocardial Reperfusion Injury; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Pyrroles; Rats; Rats, Wistar; Signal Transduction | 2012 |
Malondialdehyde and 4-hydroxynonenal adducts are not formed on cardiac ryanodine receptor (RyR2) and sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2) in diabetes.
Topics: Aldehydes; Animals; Arginine; Calcium; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Echocardiography; Guanidines; Lysine; Male; Malondialdehyde; Myocytes, Cardiac; Norleucine; Protein Carbonylation; Pyridoxamine; Pyrroles; Rats; Rats, Sprague-Dawley; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Spin Labels | 2013 |
Increased atherosclerosis in diabetic dyslipidemic swine: protection by atorvastatin involves decreased VLDL triglycerides but minimal effects on the lipoprotein profile.
Topics: Animals; Anticholesteremic Agents; Arteriosclerosis; Atorvastatin; Blood Glucose; Cholesterol; Collagen; Diabetes Mellitus, Experimental; Diet, Atherogenic; Fasting; Heptanoic Acids; Hyperlipidemias; Insulin; Lipoproteins, VLDL; Liver; Male; Pyrroles; Swine; Swine, Miniature; Triglycerides; Vitamin A; Vitamin E | 2002 |
Streptozotocin-induced diabetes increases disulfide bond formation on cardiac ryanodine receptor (RyR2).
Topics: Animals; Diabetes Mellitus, Experimental; Disulfides; Heart; Male; Myocardium; Oxidation-Reduction; Pyrroles; Rats; Rats, Sprague-Dawley; Ryanodine; Ryanodine Receptor Calcium Release Channel; Streptozocin; Tritium | 2003 |
NOVEL ORAL HYPOGLYCEMIC AGENTS. I. HEXAHYDROINDENO(1,2-C)PYRROLES AND INDANAMINES.
Topics: Animals; Chemistry, Pharmaceutical; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Indenes; Pharmacology; Pyrroles; Rabbits; Research | 1965 |
Effects of atorvastatin and pravastatin on glucose tolerance in diabetic rats mildly induced by streptozotocin.
Topics: Administration, Oral; Animals; Atorvastatin; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Glucose; Glucose Tolerance Test; Heptanoic Acids; Injections, Intravenous; Insulin; Insulin Secretion; Male; Pravastatin; Pyrroles; Rats; Rats, Sprague-Dawley; Streptozocin; Time Factors | 2003 |
Antihyperglycemic activity of 2-methyl-3,4,5-triaryl-1H-pyrroles in SLM and STZ models.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Sucrose | 2004 |
Vascular endothelial growth factor in diabetes induced early retinal abnormalities.
Topics: Animals; Capillary Permeability; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelin-1; Endothelin-3; Indoles; Male; MAP Kinase Signaling System; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A | 2004 |
Epidermal growth factor receptor inhibition attenuates early kidney enlargement in experimental diabetes.
Topics: Animals; Apoptosis; Bromodeoxyuridine; Cell Division; Cell Line; Diabetes Mellitus, Experimental; Epithelial Cells; ErbB Receptors; Glomerular Filtration Rate; Immunohistochemistry; Kidney; Kidney Glomerulus; Male; Organ Size; Proliferating Cell Nuclear Antigen; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley | 2004 |
Effects of atorvastatin on glucose metabolism and insulin resistance in KK/Ay mice.
Topics: Animals; Arteriosclerosis; Atorvastatin; Biomarkers; Blood Glucose; Blotting, Northern; CCAAT-Enhancer-Binding Proteins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Glucose Tolerance Test; Glucose-6-Phosphatase; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin Resistance; Lipids; Male; Mice; Mice, Inbred Strains; Pyrroles; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Transcription Factors | 2005 |
Atorvastatin reduces the plasma lipids and oxidative stress but did not reverse the inhibition of prostacyclin generation by aortas in streptozotocin diabetic rats.
Topics: Animals; Aorta; Atorvastatin; Diabetes Mellitus, Experimental; Epoprostenol; Heptanoic Acids; Lipids; Male; Oxidative Stress; Pyrroles; Rats; Rats, Sprague-Dawley; Streptozocin | 2005 |
Novel protein kinase C-beta isoform selective inhibitor JTT-010 ameliorates both hyper- and hypoalgesia in streptozotocin- induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hyperalgesia; Hypesthesia; Indans; Male; Neural Conduction; Protein Kinase C; Protein Kinase C beta; Pyrroles; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 2005 |
Chronic CO levels have [corrected] a beneficial effect on vascular relaxation in diabetes.
Topics: Acetylcholine; Animals; Aorta; Biliverdine; Blotting, Western; Carbon Monoxide; Chromium; Densitometry; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelium, Vascular; Femoral Artery; Guanylate Cyclase; Heme; Immunohistochemistry; Male; Mesoporphyrins; Muscle Contraction; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organometallic Compounds; Oxadiazoles; Oxidative Stress; Protoporphyrins; Pyrazines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Time Factors | 2006 |
Involvement of Rho-kinase in experimental vascular endothelial dysfunction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Antibiotics, Antineoplastic; Aorta, Thoracic; Atorvastatin; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Endothelium, Vascular; Heptanoic Acids; Homocysteine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperhomocysteinemia; Intracellular Signaling Peptides and Proteins; Male; Nitrates; Nitrites; Oxidative Stress; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrroles; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Streptozocin; Thiobarbituric Acid Reactive Substances; Vasodilation | 2006 |
Anti-inflammatory effects of atorvastatin improve left ventricular function in experimental diabetic cardiomyopathy.
Topics: Animals; Anti-Inflammatory Agents; Atorvastatin; Collagen; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Heart; Heptanoic Acids; Inflammation; Myocardium; Pyrroles; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Left; Ventricular Function, Left | 2007 |
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis.
Topics: Acetophenones; Acetylcysteine; Angiogenesis Inhibitors; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Imidazoles; Indoles; Leukostasis; Losartan; Male; NADPH Oxidases; Pyridines; Pyrroles; Rats; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Retinal Diseases; Vascular Endothelial Growth Factor A; Vasoconstrictor Agents | 2007 |
Low-dose treatment with atorvastatin leads to anti-oxidative and anti-inflammatory effects in diabetes mellitus.
Topics: Animals; Anti-Inflammatory Agents; Anticholesteremic Agents; Antioxidants; Atorvastatin; Diabetes Mellitus, Experimental; Endothelium, Vascular; Gene Expression; Heptanoic Acids; Inflammation; Inflammation Mediators; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NADPH Oxidases; Oxidative Stress; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Streptozocin; Transcription Factor RelA; Vasodilation | 2007 |
Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus.
Topics: Animals; Atorvastatin; Biopterins; Body Weight; Cell Adhesion Molecules; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; GTP Cyclohydrolase; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intramolecular Oxidoreductases; Male; Microfilament Proteins; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphoproteins; Pyrroles; Rats; Rats, Wistar; Stem Cells; Tetrahydrofolate Dehydrogenase; Vasodilation | 2008 |
Drug-induced endothelium-dependent and -independent relaxations in isolated resistance vessels taken from simultaneously hypertensive and streptozotocin-diabetic rats.
Topics: Animals; Benzopyrans; Bradykinin; Calcium; Cromakalim; Diabetes Mellitus, Experimental; Endothelium, Vascular; Glyburide; Histamine; Hypertension; Male; Mesenteric Arteries; Methacholine Chloride; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nitroprusside; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Streptozocin; Vascular Resistance; Vasodilation; Vasodilator Agents | 1994 |
Reduction in ATP-sensitive potassium channel-mediated antinociception in diabetic mice.
Topics: Adenosine Triphosphate; Analgesics; Animals; Benzopyrans; Blood Glucose; Cromakalim; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glyburide; Male; Mice; Mice, Inbred ICR; Morphine; Pain Measurement; Potassium Channels; Pyrroles; Receptors, Opioid, mu; Tetraethylammonium Compounds | 1994 |
Increase in 3-deoxyglucosone levels in diabetic rat plasma. Specific in vivo determination of intermediate in advanced Maillard reaction.
Topics: 2-Naphthylamine; Animals; Chromatography, High Pressure Liquid; Deoxyglucose; Diabetes Mellitus, Experimental; Gas Chromatography-Mass Spectrometry; Maillard Reaction; Male; Norleucine; Pyrroles; Rats; Rats, Wistar; Serum Albumin, Bovine; Spectrophotometry, Ultraviolet | 1994 |
Effect of diabetes mellitus on response of the basilar artery to activation of ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Basilar Artery; Benzopyrans; Blood Pressure; Cromakalim; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Nitroglycerin; Picolines; Potassium Channels; Pyrans; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Diabetes and ATP-sensitive potassium channel openers and blockers in isolated ischemic/reperfused hearts.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzopyrans; Cations; Cromakalim; Diabetes Mellitus, Experimental; Glyburide; Heart Function Tests; Hypoglycemic Agents; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Streptozocin | 1995 |
Normalization of insulin secretion by a selective alpha 2-adrenoceptor antagonist restores GLUT-4 glucose transporter expression in adipose tissue of type II diabetic rats.
Topics: Adipose Tissue; Adipose Tissue, Brown; Adrenergic alpha-Antagonists; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gene Expression; Glucose Tolerance Test; Glucose Transporter Type 4; Indoles; Insulin; Insulin Secretion; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Myocardium; Pyrroles; Rats; Rats, Wistar; RNA, Messenger | 1996 |
Effects of cromakalim and glibenclamide in ischemic and reperfused hearts.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Cromakalim; Diabetes Mellitus, Experimental; Glyburide; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Pyrroles; Rats; Rats, Sprague-Dawley | 1996 |
Inhibitory effects of tenilsetam on the Maillard reaction.
Topics: Animals; Aorta; Blood Glucose; Collagen; Deoxyglucose; Diabetes Mellitus, Experimental; Fructose; Glucose; Glycated Hemoglobin; Kidney Cortex; Macromolecular Substances; Maillard Reaction; Male; Muramidase; Norleucine; Piperazines; Psychotropic Drugs; Pyrroles; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Thiophenes | 1997 |
Evaluation of BTS 67 582, a novel antidiabetic agent, in normal and diabetic rats.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Glucose; Brain; Cromakalim; Diabetes Mellitus, Experimental; Diazoxide; Glucose; Glyburide; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Insulin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channel Blockers; Pyrroles; Rats; Rats, Wistar; Tumor Cells, Cultured | 1997 |
Extracellular Mg++ manipulation prevents the proarrhythmic activity of cromakalim in ischemic/reperfused diabetic hearts.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Calcium; Cromakalim; Diabetes Mellitus, Experimental; Heart; Magnesium; Male; Myocardial Ischemia; Myocardial Reperfusion; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Sodium; Streptozocin | 1997 |
Effects of gastroprokinetic agents on gastroparesis in streptozotocin-induced diabetic rats.
Topics: Animals; Benzamides; Benzimidazoles; Blood Glucose; Cisapride; Diabetes Mellitus, Experimental; Gastric Emptying; Gastrointestinal Motility; Gastroparesis; Granisetron; Male; Morpholines; Ondansetron; Piperidines; Pyrroles; Rats; Rats, Wistar; Serotonin Antagonists; Serotonin Receptor Agonists; Vagotomy | 1997 |
Mechanisms of the hypoglycemic effects of the alpha2-adrenoceptor antagonists SL84.0418 and deriglidole.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Chlorisondamine; Diabetes Mellitus, Experimental; Diazoxide; Female; Glucose Tolerance Test; Hypoglycemic Agents; Imidazoles; Indoles; Insulin; Insulin Antagonists; Insulin Secretion; Male; Mice; Norepinephrine; Propranolol; Pyrroles; Rats; Rats, Sprague-Dawley; Species Specificity | 1998 |
Modification of the expression of naloxone-precipitated withdrawal signs in morphine-dependent mice by diabetes: possible involvement of protein kinase C.
Topics: Animals; Behavior, Animal; Carbazoles; Carcinogens; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Frontal Lobe; Indoles; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Naloxone; Naphthalenes; Narcotic Antagonists; Narcotics; Norepinephrine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrroles; Substance Withdrawal Syndrome | 1999 |
Low phagocytic activity of resident peritoneal macrophages in diabetic mice: relevance to the formation of advanced glycation end products.
Topics: Adenosine Triphosphate; Animals; Cattle; Cell Separation; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Female; Flow Cytometry; Glycation End Products, Advanced; Indoles; Macrophages, Peritoneal; Maleimides; Mice; Mice, Inbred BALB C; NG-Nitroarginine Methyl Ester; Norleucine; Phagocytosis; Protein Kinase C; Pyrroles | 1999 |
Effects of new antioxidant compounds PNU-104067F and PNU-74389G on antioxidant defense in normal and diabetic rats.
Topics: Animals; Antioxidants; Body Weight; Diabetes Mellitus, Experimental; Liver; Male; Organ Size; Pregnatrienes; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley | 2000 |
p-Dimethylaminobenzaldehyde-reactive substances in tail tendon collagen of streptozotocin-diabetic rats: temporal relation to biomechanical properties and advanced glycation endproduct (AGE)-related fluorescence.
Topics: Animals; Benzaldehydes; Collagen; Diabetes Mellitus, Experimental; Disease Models, Animal; Enzyme Inhibitors; Glycation End Products, Advanced; Guanidines; Indicators and Reagents; Male; Pepsin A; Pyrroles; Rats; Rats, Wistar; Spectrophotometry; Stress, Mechanical; Tail; Tendons; Time Factors | 2000 |
Effect of atorvastatin on intracellular calcium uptake in coronary smooth muscle cells from diabetic pigs fed an atherogenic diet.
Topics: Animals; Atorvastatin; Caffeine; Calcium; Coronary Vessels; Cytoplasm; Diabetes Mellitus, Experimental; Diet, Atherogenic; Fluorescent Dyes; Fura-2; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; In Vitro Techniques; Ionomycin; Ionophores; Male; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Pyrroles; Sarcoplasmic Reticulum; Sodium; Swine; Swine, Miniature; Thapsigargin | 2001 |
Changes in responsiveness of the aorta to vasorelaxant agents in genetically diabetic rats: a study in WBN/Kob rats.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Colforsin; Cromakalim; Diabetes Mellitus, Experimental; Endothelium, Vascular; Isoproterenol; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Vasodilator Agents | 1992 |
Hormone-regulated K+ channels in follicle-enclosed oocytes are activated by vasorelaxing K+ channel openers and blocked by antidiabetic sulfonylureas.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic AMP; Diabetes Mellitus, Experimental; Female; Hormones; Oocytes; Potassium Channels; Pyrroles; Sulfonylurea Compounds; Vasodilator Agents; Xenopus laevis | 1991 |
Relation of Na+, K(+)-ATPase to delayed motor nerve conduction velocity: effect of aldose reductase inhibitor, ADN-138, on Na+, K(+)-ATPase activity.
Topics: Aldehyde Reductase; Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Inositol; Male; Motor Activity; Nervous System Physiological Phenomena; Neural Conduction; Oxazines; Pyrroles; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase; Sugar Alcohol Dehydrogenases; Time Factors | 1990 |
Functional changes in potassium channels in aortas from rats with streptozotocin-induced diabetes.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Glucose; Cromakalim; Diabetes Mellitus, Experimental; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Niacinamide; Nicorandil; Norepinephrine; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1989 |
Effect of a new aldose reductase inhibitor, 8'-chloro-2',3'-dihydrospiro [pyrrolidine-3,6'(5'H)-pyrrolo[1,2,3-de] [1,4]benzoxazine]-2,5,5'- trione (ADN-138), on delayed motor nerve conduction velocity in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Motor Neurons; Neural Conduction; Oxazines; Pyrroles; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohol Dehydrogenases | 1988 |
The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Electroretinography; Galactitol; Galactosemias; Hyperglycemia; Inositol; Insulin; Male; Oxazines; Pyrroles; Rats; Rats, Inbred Strains; Retina; Sorbitol; Sugar Alcohols | 1988 |
The pharmacology of S 1702, a new highly effective oral antidiabetic drug with unusual properties. 2. Protective activity of S 1702 on the microvascular system in normal and diabetic rats.
Topics: Animals; Blood Coagulation Tests; Capillaries; Capillary Permeability; Cyclopentanes; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Hypoglycemic Agents; Male; Mesentery; Pyrroles; Rats; Skin; Sulfonylurea Compounds; Thrombosis | 1972 |
Salicylate hypoglycemic action in alloxan-diabetic rats and structural relationships.
Topics: Animals; Benzene Derivatives; Blood Glucose; Diabetes Mellitus, Experimental; Female; Heterocyclic Compounds; Male; Mass Screening; Nicotinic Acids; Pyrazines; Pyridinium Compounds; Pyrimidines; Pyrroles; Rats; Salicylates; Thiophenes | 1968 |