Compounds > pyrroles
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pyrroles and Adjuvant Arthritis

pyrroles has been researched along with Adjuvant Arthritis in 65 studies

Research

Studies (65)

TimeframeStudies, this research(%)All Research%
pre-19909 (13.85)18.7374
1990's10 (15.38)18.2507
2000's10 (15.38)29.6817
2010's33 (50.77)24.3611
2020's3 (4.62)2.80

Authors

AuthorsStudies
Bedaj, M; Benson, RA; Bonilha, CS; Garside, P; McInnes, IB1
Abria, C; Chaudhari, AJ; Harmany, ZT; Kundu-Raychaudhuri, S; Raychaudhuri, S; Raychaudhuri, SP; Smith, CM1
Kato, F; Kurosaka, D; Oto, Y; Takahashi, Y1
Ibrahim, SSA; Salama, MA; Selima, E; Shehata, RR1
Alesse, E; Berardicurti, O; Ciccia, F; Cipriani, P; Di Benedetto, P; Di Francesco, B; Di Vito Nolfi, M; Dolo, V; Giacomelli, R; Grazia, N; Guggino, G; Maurizi, A; Navarini, L; Panzera, N; Rucci, N; Ruscitti, P; Teti, AM; Zazzeroni, F1
Amital, H; Gertel, S; Karmon, G; Mahagna, H; Watad, A1
Poorvashree, J; Suneela, D1
Chen, L; He, L; Lan, T; Pei, H; Tang, M; Zhang, C1
Arnold, EP; Banker, ME; Basak, A; Brown, MF; Casavant, JM; Caspers, N; Clark, JD; Dowty, ME; Duclos, BA; Fenwick, AE; Flanagan, ME; Griffin, SH; Han, S; Harris, TM; Heasley, SE; Hegen, M; Johnson, TA; Jussif, J; Kaila, N; Kwon, S; Langille, J; Li, L; Lin, TH; Mitton-Fry, MJ; Parikh, MD; Robinson, RP; Strohbach, JW; Symanowicz, PT; Telliez, JB; TenBrink, RE; Trzupek, JD; Unwalla, R; Vazquez, ML; Wang, L; Yang, X1
Fukuda, I; Hasegawa, M; Higashino, K; Hinata, M; Horita, N; Ikeda, M; Imai, M; Imai, S; Kanemasa, T; Minami, M; Morioka, Y; Morita, A; Sakaguchi, G; Sanaki, T; Soga, M; Tsuchida, J; Yamamoto, M; Yamane, S; Yoshioka, T1
Galdamez, J; Goldring, SR; Lele, SM; Liu, Y; Mikuls, TR; Purdue, PE; Soni, DM; Wang, D; Wang, X; Wei, X; Wu, J; Zhao, G1
Chen, L; He, J; Li, W; Niu, T; Pei, H; Xiang, M; Zhang, C; Zhu, J1
Almon, RR; DuBois, DC; Jusko, WJ; Song, D; Yu, R1
Aliagas, I; Avitabile-Woo, B; Balazs, M; Barrett, K; Bergeron, P; Bir Kohli, P; Blair, WS; Bull, R; Chakravarty, P; Chang, C; Crackett, P; Deshmukh, G; DeVoss, J; Dragovich, PS; Eigenbrot, C; Ellwood, C; Gaines, S; Ghilardi, N; Gibbons, P; Gradl, S; Gribling, P; Hamman, C; Harstad, E; Hewitt, P; Hurley, CA; Johnson, A; Johnson, T; Kenny, JR; Koehler, MF; Kulagowski, JJ; Labadie, S; Lee, WP; Liao, J; Liimatta, M; Mendonca, R; Narukulla, R; Pulk, R; Reeve, A; Savage, S; Shia, S; Steffek, M; Ubhayakar, S; van Abbema, A; Ward, SI; Xiao, Y; Yang, J; Zak, M1
Dowty, ME; Ghosh, S; Jesson, MI; Kishore, N; Krishnaswami, S; Lee, J; Meyer, DM1
Furuya, K; Joh, K; Kaku, Y; Kurosaka, D; Yoshida, K1
Akashi, K; Kageyama, G; Matsuki, F; Morinobu, A; Nishimura, K; Saegusa, J1
Cooray, SN; Gobbetti, T; Jonassen, TE; Montero-Melendez, T; Perretti, M1
Graepel, R; Lopes, F; McDougall, JJ; McKay, DM; Petri, B; Reyes, JL; Sharkey, KA; Wang, A1
Cendón, C; Chang, HD; Di Ceglie, I; Douni, E; Gómez, L; Kamradt, T; Llop-Guevara, A; Madarena, F; Porras, M; Rinotas, V; Román, J; Siracusa, F; van Lent, PL1
Balbo, P; Banker, ME; Bauman, J; Brown, MF; Casimiro-Garcia, A; Clark, JD; Crouse, K; Dickinson, C; Dowty, ME; Geoghegan, KF; Gilbert, AM; Hayward, M; Hegen, M; Hett, E; Jones, L; Jussif, J; Leung, L; Li, L; Li, W; Liang, S; Lin, T; Montgomery, J; Moy, E; Quazi, A; Symanowicz, P; Telliez, JB; Thorarensen, A; Trujillo, JI; Unwalla, R; Vajdos, FF; Vincent, F; Wang, L; Wright, K; Xuan, D; Yang, X; Zhao, Y1
Alpert, C; Bays, N; Byford, A; Chakravarthy, K; Chiu, CS; Dandliker, PJ; Deshmukh, SV; Dinsmore, C; Dorosh, L; Elwood, F; Goldenblatt, P; Ivanovska, I; Kariv, I; Klappenbach, J; Kraybill, B; Lee, HH; Pan, BS; Piesvaux, J; Qu, Y; Rivkin, A; Scott, ME; Slipetz, D; Tang, H; Witter, DJ; Zielstorff, M1
Kumar, VL; Wahane, VD1
Aoki, K; Doi, H; Kagari, T; Nagasaki, T; Nakao, A; Ohkawa, N; Shimozato, T; Ushiyama, S1
Bentzien, J; Dinallo, R; Fadra, TN; Gilmore, T; Harcken, C; Kukulka, A; Kuzmich, D; Nabozny, GH; Nelson, RM; Pack, EJ; Panzenbeck, M; Pelletier, J; Razavi, H; Riether, D; Souza, D; Thomson, DS; Torcellini, C; Zuvela-Jelaska, L1
Barrish, JC; Dodd, JH; Doweyko, AM; Dyckman, AJ; Gillooly, KM; Hynes, J; Kiefer, SE; Kish, KF; Leftheris, K; Li, T; Lin, J; Lin, S; Liu, C; Marathe, PH; McIntyre, KW; McKinnon, M; Newitt, JA; Pitt, S; Sack, JS; Salter-Cid, L; Schieven, GL; Shen, DR; Shuster, DJ; Wityak, J; Wrobleski, ST; Wu, H; Zhang, H; Zhang, RF1
Guruprasad, B; Kumar, VL; Wahane, VD1
Alsup, JW; Dowty, ME; Gadina, M; Ghoreschi, K; Ghosh, S; Head, RD; Jesson, MI; Kishore, N; LaBranche, TP; Lee, JL; Li, X; Meyer, DM; Minnerly, JC; O'Shea, JJ; Radi, ZA; Steward-Tharp, SM; Storer, CE; Tanaka, M; Thomas, CJ; Warner, JD1
Andersson, S; Bokarewa, M; Brisslert, M; Dehlin, M; Erlandsson, M1
Barbosa, CP; Bersani-Amado, CA; Bracht, A; Bracht, L; Caparroz-Assef, SM; Cuman, RK; Ishii-Iwamoto, EL1
Asakawa, M; Chiba, K; Kawasumi, M; Kobayashi, T; Miyamoto, T; Mori, T; Morioka, H; Toyama, Y; Yoshida, H; Yoshimura, A1
Abd El-Halim, MS; Abdin, AA; El-Saadany, AA; Hedeya, SE1
Balagué, C; Godessart, N; Pont, M; Prats, N1
Cho, YW; Lee, JY; Lee, KT; Noh, YS; Shin, JS; Yoo, MS1
Maeshima, K; Maeshima, Y; Tanaka, Y; Yamaoka, K1
Bailey, SA; Bansal, PN; Bollinger, CS; Bonar, SL; Guzova, JA; Happa, FA; Head, RD; Hegen, M; Jesson, MI; Kishore, N; LaBranche, TP; Mbalaviele, G; Meyer, DM; Radi, ZA; Stewart, ZS; Storer, CE; Symanowicz, PT; Thompson, JM; Wellen, JW; Wilkie, DP; Zhan, Y1
Fernandes, JC; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Pelletier, JP1
Bai, AP; Bai, JY; Chen, XH; Cheng, GF; Guo, ZR; Shen, F1
Busso, N; Chobaz, V; Gabay, C; Palmer, G; So, A; Talabot-Ayer, D; Taylor, S1
Aoki, K; Kimura, T; Nakajima-Yamada, T; Shimozato, T; Tsuchida, J; Ushiyama, S; Wada, Y; Yamada, K; Yasumoto, T1
Barsante, MM; Castro, MS; Pinho, V; Roffê, E; Souza, DG; Tafuri, WL; Teixeira, MM; Yokoro, CM1
de Vegvar, HE; Digennaro, C; Higgins, JP; Ho, PP; Kidd, BA; Lee, LY; Robinson, WH; Steinman, L; Tomooka, B1
Barrish, JC; Behnia, K; Dodd, J; Doweyko, AM; Dyckman, AJ; Gillooly, KM; Hynes, J; Kanner, SB; Kiefer, SE; Leftheris, K; Lin, S; Lonial, H; Loo, D; Marathe, PH; McIntyre, KW; Newitt, JA; Pitt, S; Pokross, M; Sack, JS; Schieven, GL; Shen, DR; Shuster, DJ; Tokarski, JS; Wrobleski, ST; Wu, H; Yang, X; Zhang, H; Zhang, R1
Audoly, L; Changelian, P; Kudlacz, EM; Milici, AJ; Zwillich, S1
Burdisso, M; Leali, M; Panzone, G; Schiatti, P; Selva, D; Tarzia, G1
Gardocki, JF; Wong, S1
Maloney, PJ; Rooks, WH; Schuler, ME; Tomolonis, AJ; Wallach, MB1
Grindel, JM1
Kadokawa, T; Motoyoshi, S; Nakamura, H; Seto, Y; Shimizu, M; Yokoyama, Y1
Anderson, NG; Carson, JR1
Albrecht, W; Algate, DR; Atterson, PR; Augustin, J; Elsässer, R; Guserle, R; Laufer, S; Munt, PL; Tries, S1
Augustin, J; Dannhardt, G; Laufer, S; Tries, S1
Birchall, AM; Bishop, J; Bradshaw, D; Cline, A; Coffey, J; Elliott, LH; Gibson, VM; Greenham, A; Hallam, TJ; Harris, W1
Galbraith, W; Gans-Brangs, K; Grubb, M; Hewes, WE; Jaffee, B; Kenney, JP; Kerr, J; Wilkerson, WW; Wong, N1
DiMartino, M; Nambi, P; Patil, A; Wolff, C1
Antoon, JS; Perry, MA; Walker, JS; Wilson, JL1
Cavender, DE; Davis, JE; Dodd, JH; Fahmy, B; Henry, JR; Olini, GC; Pellegrino-Gensey, JL; Rupert, KC; Schafer, PH; Siekierka, JJ; Turchi, IJ; Wadsworth, SA1
Agarwal, L; Chang, L; Chin, J; Croft, G; de Laszlo, SE; Fletcher, D; Forsyth, A; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Keefe, SJ; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; Visco, D1
Gay, RE; Gay, S; Laufer, S; Neidhart, M; Pataky, F; Tries, S1
Barrientos, RM; Chrousos, GP; Contoreggi, C; Gabry, KE; Gold, PW; Isaac, MG; Ligier, S; McCarthy, EF; Rice, KC; Sternberg, EM; Webster, EL1
Panzone, G; Schiatti, P; Selva, D; Tarzia, G1
Bryant, RW; Kaminski, JJ; Lee, JF; McPhail, AT; Sherlock, MH; Ting, PC; Tom, WC; Watnick, AS1
Arrigoni-Martelli, E1
Carson, J; Fisher, MC; Persico, FJ; Pritchard, JF; Wong, S; Yorgey, K1
Cenarruzabeitia, E; Lasheras, B; Ucelay, M1

Reviews

1 review(s) available for pyrroles and Adjuvant Arthritis

ArticleYear
The pharmacokinetic and metabolic profile of the antiinflammatory agent tolmetin in laboratory animals and man.
    Drug metabolism reviews, 1981, Volume: 12, Issue:2

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Biological Availability; Guinea Pigs; Humans; Kinetics; Mice; Pyrroles; Rats; Species Specificity; Tissue Distribution; Tolmetin

1981

Trials

2 trial(s) available for pyrroles and Adjuvant Arthritis

ArticleYear
Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis.
    The Journal of pharmacology and experimental therapeutics, 2014, Volume: 348, Issue:1

    Topics: Animals; Arthritis, Experimental; Double-Blind Method; Drug Evaluation, Preclinical; Humans; Janus Kinase 1; Janus Kinase 3; Male; Mice; Mice, Inbred DBA; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles

2014
In vitro and in vivo analysis of a JAK inhibitor in rheumatoid arthritis.
    Annals of the rheumatic diseases, 2012, Volume: 71 Suppl 2

    Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Isoenzymes; Janus Kinase 3; Mice; Mice, SCID; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction

2012

Other Studies

62 other study(ies) available for pyrroles and Adjuvant Arthritis

ArticleYear
Tofacitinib inhibits CD4 T cell polarisation to Th1 during priming thereby leading to clinical impact in a model of experimental arthritis.
    Clinical and experimental rheumatology, 2022, Volume: 40, Issue:7

    Topics: Animals; Arthritis, Experimental; CD4-Positive T-Lymphocytes; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles

2022
Quantitative tracking of inflammatory activity at the peak and trough plasma levels of tofacitinib, a Janus kinase inhibitor, via in vivo
    International journal of rheumatic diseases, 2019, Volume: 22, Issue:12

    Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Drug Administration Schedule; Fluorodeoxyglucose F18; Janus Kinase Inhibitors; Joints; Male; Mice, Inbred DBA; Piperidines; Positron-Emission Tomography; Predictive Value of Tests; Pyrimidines; Pyrroles; Radiopharmaceuticals; Whole Body Imaging

2019
Alterations of voluntary behavior in the course of disease progress and pharmacotherapy in mice with collagen-induced arthritis.
    Arthritis research & therapy, 2019, 12-12, Volume: 21, Issue:1

    Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Disease Progression; Humans; Joints; Male; Mice, Inbred DBA; Motor Activity; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Synovitis; Temperature

2019
Sitagliptin and tofacitinib ameliorate adjuvant induced arthritis via modulating the cross talk between JAK/STAT and TLR-4/NF-κB signaling pathways.
    Life sciences, 2020, Nov-01, Volume: 260

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Blood Glucose; Drug Synergism; Drug Therapy, Combination; Hypoglycemic Agents; Interleukin-6; Janus Kinases; Lipids; Male; NF-kappa B; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Signal Transduction; Sitagliptin Phosphate; STAT Transcription Factors; STAT3 Transcription Factor; Toll-Like Receptor 4

2020
Blocking Jak/STAT signalling using tofacitinib inhibits angiogenesis in experimental arthritis.
    Arthritis research & therapy, 2021, 08-14, Volume: 23, Issue:1

    Topics: Animals; Arthritis, Experimental; Endothelial Cells; Humans; Mice; Piperidines; Pyrimidines; Pyrroles; Synovial Membrane

2021
Tofacitinib attenuates arthritis manifestations and reduces the pathogenic CD4 T cells in adjuvant arthritis rats.
    Clinical immunology (Orlando, Fla.), 2017, Volume: 184

    Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; C-Reactive Protein; CD4-Positive T-Lymphocytes; Foot; Foot Joints; Forelimb; Hindlimb; Interferon-gamma; Interleukin-1beta; Methotrexate; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spleen

2017
Novel drug delivery of dual acting prodrugs of hydroxychloroquine with aryl acetic acid NSAIDs: Design, kinetics and pharmacological study.
    Drug delivery and translational research, 2017, Volume: 7, Issue:5

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Carrageenan; Diclofenac; Drug Design; Female; Freund's Adjuvant; Hydroxychloroquine; Inflammation; Male; Mice; Prodrugs; Pyrroles; Rats; Rats, Wistar

2017
Design and Synthesis of a Highly Selective JAK3 Inhibitor for the Treatment of Rheumatoid Arthritis.
    Archiv der Pharmazie, 2017, Volume: 350, Issue:11

    Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Progression; Female; Humans; Inhibitory Concentration 50; Janus Kinase 3; Male; Mass Spectrometry; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley

2017
Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.
    Journal of medicinal chemistry, 2018, 02-08, Volume: 61, Issue:3

    Topics: Animals; Arthritis, Experimental; Autoimmune Diseases; Cyclobutanes; Dogs; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Janus Kinase 1; Janus Kinase 2; Models, Molecular; Protein Conformation; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Substrate Specificity; Sulfonamides; Tissue Distribution

2018
Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis.
    Pain, 2018, Volume: 159, Issue:5

    Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Ganglia, Spinal; Hand Strength; Iodoacetic Acid; Leucine; Male; Morpholines; Neurons; Osteoarthritis; Pain; Pain Measurement; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides; TRPV Cation Channels

2018
Development of a Janus Kinase Inhibitor Prodrug for the Treatment of Rheumatoid Arthritis.
    Molecular pharmaceutics, 2018, 08-06, Volume: 15, Issue:8

    Topics: Acrylamides; Administration, Oral; Animals; Ankle Joint; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Janus Kinase Inhibitors; Janus Kinases; Macrophages; Male; Mice, Inbred C57BL; Piperidines; Primary Cell Culture; Prodrugs; Pyrimidines; Pyrroles; Rats; Rats, Inbred Lew; Signal Transduction; STAT6 Transcription Factor; Tissue Distribution; Treatment Outcome; X-Ray Microtomography

2018
Design, synthesis and evaluation of novel 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as potent, selective and reversible Bruton's tyrosine kinase (BTK) inhibitors for the treatment of rheumatoid arthritis.
    European journal of medicinal chemistry, 2019, May-01, Volume: 169

    Topics: Agammaglobulinaemia Tyrosine Kinase; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Collagen; Dose-Response Relationship, Drug; Drug Design; Humans; Male; Mice; Mice, Inbred DBA; Molecular Docking Simulation; Molecular Structure; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Structure-Activity Relationship

2019
Modeling Combined Anti-Inflammatory Effects of Dexamethasone and Tofacitinib in Arthritic Rats.
    The AAPS journal, 2019, 07-24, Volume: 21, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Dexamethasone; Disease Progression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Edema; Male; Pilot Projects; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Inbred Lew

2019
Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2.
    Journal of medicinal chemistry, 2013, Jun-13, Volume: 56, Issue:11

    Topics: Administration, Oral; Animals; Antirheumatic Agents; Arthritis, Experimental; Biological Availability; Cell Membrane Permeability; Collagen; Crystallography, X-Ray; Dogs; Haplorhini; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Isoenzymes; Janus Kinase 1; Janus Kinase 2; Madin Darby Canine Kidney Cells; Microsomes, Liver; Models, Molecular; Molecular Structure; Pyridines; Pyrroles; Rats; Stereoisomerism

2013
Therapeutic effects of sunitinib, one of the anti-angiogenetic drugs, in a murine arthritis.
    Modern rheumatology, 2014, Volume: 24, Issue:3

    Topics: Animals; Ankle Joint; Antirheumatic Agents; Arthritis, Experimental; Bone Density; Indoles; Mice; Pyrroles; Sunitinib; Treatment Outcome; Wrist Joint

2014
Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates arthritis in SKG mice.
    Arthritis & rheumatology (Hoboken, N.J.), 2015, Volume: 67, Issue:4

    Topics: Animals; Arthritis, Experimental; CD4-Positive T-Lymphocytes; Cell Differentiation; Dendritic Cells; Female; Mice; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles

2015
Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects.
    Journal of immunology (Baltimore, Md. : 1950), 2015, Apr-01, Volume: 194, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Calcium; Disease Models, Animal; Gene Knockout Techniques; Guanidines; HEK293 Cells; Humans; Inflammation; Macrophages, Peritoneal; Male; Melanins; Melanoma, Experimental; Mice; Neutrophils; Peritonitis; Phagocytosis; Pyrroles; Receptor, Melanocortin, Type 1; Receptor, Melanocortin, Type 3; Receptors, Melanocortin; Signal Transduction

2015
Involvement of Mast Cells in α7 Nicotinic Receptor Agonist Exacerbation of Freund's Complete Adjuvant-Induced Monoarthritis in Mice.
    Arthritis & rheumatology (Hoboken, N.J.), 2016, Volume: 68, Issue:2

    Topics: Aconitine; Adjuvants, Immunologic; alpha7 Nicotinic Acetylcholine Receptor; Animals; Apolipoproteins E; Arthritis, Experimental; Bridged-Ring Compounds; Cell Movement; Cell Proliferation; Disease Models, Animal; Disease Progression; Freund's Adjuvant; Inflammation; Injections, Intra-Articular; Lipopolysaccharides; Male; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nicotinic Antagonists; Peptide Fragments; Pyrroles; Spiro Compounds; Xanthones

2016
Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice.
    Arthritis research & therapy, 2015, Dec-10, Volume: 17

    Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cyclohexylamines; Disease Models, Animal; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immunophenotyping; Intracellular Signaling Peptides and Proteins; Janus Kinases; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Syk Kinase

2015
Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition.
    ACS chemical biology, 2016, 12-16, Volume: 11, Issue:12

    Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Drug Discovery; Encephalomyelitis, Autoimmune, Experimental; Humans; Interleukin-10; Interleukin-1beta; Janus Kinase 1; Janus Kinase 3; Macrophages; Mice; Models, Molecular; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Th1 Cells; Th17 Cells; Tumor Necrosis Factor-alpha

2016
Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor.
    The Journal of pharmacology and experimental therapeutics, 2017, Volume: 361, Issue:2

    Topics: Animals; Arthritis, Experimental; Autoimmune Diseases; Dose-Response Relationship, Drug; Drug Monitoring; Humans; Isoenzymes; Janus Kinase 1; Janus Kinase 3; Monitoring, Immunologic; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats

2017
Atorvastatin ameliorates inflammatory hyperalgesia in rat model of monoarticular arthritis.
    Pharmacological research, 2010, Volume: 61, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Atorvastatin; Diclofenac; Female; Freund's Adjuvant; Heptanoic Acids; Hyperalgesia; Inflammation; Joints; Lower Extremity; Male; Motor Activity; Pyrroles; Rats; Rats, Wistar

2010
Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: part 3.
    Bioorganic & medicinal chemistry letters, 2010, Aug-15, Volume: 20, Issue:16

    Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Cytokines; Humans; Indolizines; Interleukin-1beta; Interleukin-6; Interleukin-8; Mice; Pyridines; Pyrroles; Rats; Structure-Activity Relationship; Tumor Necrosis Factor-alpha

2010
Nonsteroidal dissociated glucocorticoid agonists containing azaindoles as steroid A-ring mimetics.
    Journal of medicinal chemistry, 2010, Sep-23, Volume: 53, Issue:18

    Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aromatase; Aromatase Inhibitors; Arthritis, Experimental; Biological Availability; Cells, Cultured; Enzyme Induction; Female; Humans; Hydrogen Bonding; Insulin; Interleukin-1; Interleukin-6; Mice; Mice, Inbred BALB C; Models, Molecular; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Stereoisomerism; Steroids; Structure-Activity Relationship; Transcriptional Activation

2010
Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases.
    Journal of medicinal chemistry, 2010, Sep-23, Volume: 53, Issue:18

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Biological Availability; Caco-2 Cells; Crystallography, X-Ray; Female; Humans; Hydrogen Bonding; In Vitro Techniques; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Mitogen-Activated Protein Kinase 14; Models, Molecular; Molecular Conformation; Protein Binding; Pyrroles; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Triazines; Tumor Necrosis Factor-alpha

2010
Atorvastatin exhibits anti-inflammatory and anti-oxidant properties in adjuvant-induced monoarthritis.
    Inflammopharmacology, 2010, Volume: 18, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Experimental; Atorvastatin; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Glutathione; Heptanoic Acids; Hyperalgesia; Injections, Intra-Articular; Joints; Male; Oxidative Stress; Pyrroles; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2010
Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550).
    Journal of immunology (Baltimore, Md. : 1950), 2011, Apr-01, Volume: 186, Issue:7

    Topics: Adaptive Immunity; Animals; Arthritis, Experimental; Avian Proteins; Cells, Cultured; Chickens; Collagen Type II; Humans; Immunity, Innate; Janus Kinase 3; MAP Kinase Signaling System; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles

2011
Inhibition of fms-like tyrosine kinase 3 alleviates experimental arthritis by reducing formation of dendritic cells and antigen presentation.
    Journal of leukocyte biology, 2011, Volume: 90, Issue:4

    Topics: Animals; Antigen Presentation; Antineoplastic Agents; Arthritis, Experimental; Autoantibodies; Bone and Bones; Cartilage; Dendritic Cells; fms-Like Tyrosine Kinase 3; Humans; Indoles; Joints; Mice; Mice, Inbred BALB C; Pyrroles; Sunitinib; Synovitis

2011
Effects of simvastatin, atorvastatin, ezetimibe, and ezetimibe + simvastatin combination on the inflammatory process and on the liver metabolic changes of arthritic rats.
    Fundamental & clinical pharmacology, 2012, Volume: 26, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Atorvastatin; Azetidines; Drug Therapy, Combination; Ezetimibe; Heptanoic Acids; Leukocyte Count; Leukocytes; Liver; Liver Function Tests; Perfusion; Pyrroles; Rats; Rats, Sprague-Dawley; Simvastatin

2012
IL-1β and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis.
    International immunology, 2011, Volume: 23, Issue:11

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Chronic Disease; Enzyme Inhibitors; Fibroblasts; Gene Expression; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Joints; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Osteoclasts; Piperidines; Pyrimidines; Pyrroles; RANK Ligand; Signal Transduction; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha

2011
Effect of atorvastatin with or without prednisolone on Freund's adjuvant induced-arthritis in rats.
    European journal of pharmacology, 2012, Feb-15, Volume: 676, Issue:1-3

    Topics: Animals; Ankle Joint; Arthritis, Experimental; Atorvastatin; Drug Interactions; Freund's Adjuvant; Heptanoic Acids; Lipids; Male; Oxidative Stress; Prednisolone; Pyrroles; Rats

2012
Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study.
    British journal of pharmacology, 2012, Volume: 166, Issue:4

    Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Crotonates; Dihydroorotate Dehydrogenase; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Gastrointestinal Tract; Half-Life; Hydroxybutyrates; Hypercholesterolemia; Immunosuppressive Agents; Janus Kinases; Joints; Leukocyte Disorders; Male; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; p38 Mitogen-Activated Protein Kinases; Piperidines; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Splenomegaly; Toluidines; Weight Loss

2012
Anti-inflammatory and anti-arthritic effects of new synthetic 3-(4-hydroxyphenyl)-4-(4-thiomethoxyphenyl)-1H-pyrrole-2,5-dione.
    Bioorganic & medicinal chemistry letters, 2012, Mar-15, Volume: 22, Issue:6

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Macrophages; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrroles; Rats; Rats, Sprague-Dawley

2012
JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production.
    Arthritis and rheumatism, 2012, Volume: 64, Issue:11

    Topics: Animals; Arthritis, Experimental; Bone Resorption; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Female; Humans; Janus Kinases; Macrophages; Monocytes; Osteoclasts; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; RANK Ligand; Rats; Rats, Inbred Lew; Signal Transduction; T-Lymphocytes

2012
Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis.
    Annals of the rheumatic diseases, 2004, Volume: 63, Issue:1

    Topics: Acetates; Animals; Antirheumatic Agents; Arthritis, Experimental; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Enzyme Inhibitors; Insulin-Like Growth Factor I; Leukotriene B4; Lipoxygenase Inhibitors; Osteoarthritis; Osteoblasts; Pyrroles; Urokinase-Type Plasminogen Activator

2004
Imrecoxib: a novel and selective cyclooxygenase 2 inhibitor with anti-inflammatory effect.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Humans; Isoenzymes; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Prostaglandin-Endoperoxide Synthases; Pyrroles; Rats; Rats, Wistar; RNA, Messenger; Sulfides; U937 Cells

2004
Assessment of the efficacy of different statins in murine collagen-induced arthritis.
    Arthritis and rheumatism, 2004, Volume: 50, Issue:12

    Topics: Animals; Arthritis, Experimental; Atorvastatin; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Fluorobenzenes; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Lymph Nodes; Male; Mice; Mice, Inbred DBA; Nuclear Proteins; Pyrimidines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Trans-Activators; Treatment Outcome

2004
R-130823, a novel inhibitor of p38 MAPK, ameliorates hyperalgesia and swelling in arthritis models.
    European journal of pharmacology, 2005, Jan-04, Volume: 506, Issue:3

    Topics: Animals; Arthritis, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hyperalgesia; Male; Mice; Mice, Inbred DBA; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrroles; Rats; Rats, Inbred Lew

2005
Anti-inflammatory and analgesic effects of atorvastatin in a rat model of adjuvant-induced arthritis.
    European journal of pharmacology, 2005, Jun-15, Volume: 516, Issue:3

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Atorvastatin; Chemokine CCL2; Chemokine CCL5; Chemokines, CC; Dose-Response Relationship, Drug; Edema; Female; Heptanoic Acids; Hindlimb; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperalgesia; Interleukin-1; Interleukin-10; Interleukin-6; Leukocytes; Neutrophils; Peroxidase; Pyrroles; Rats; Tarsal Joints; Time Factors; Tumor Necrosis Factor-alpha

2005
Tolerizing DNA vaccines for autoimmune arthritis.
    Autoimmunity, 2006, Volume: 39, Issue:8

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Atorvastatin; Autoantibodies; Collagen; Cytokines; Heptanoic Acids; Hindlimb; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-4; Joints; Male; Mice; Mice, Inbred DBA; Protein Array Analysis; Pyrroles; Systems Biology; Vaccines, DNA

2006
Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors.
    Journal of medicinal chemistry, 2008, Jan-10, Volume: 51, Issue:1

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Binding Sites; Crystallography, X-Ray; Drug Design; Female; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Mitogen-Activated Protein Kinase 14; Models, Molecular; Pyrroles; Rats; Rats, Inbred Lew; Structure-Activity Relationship; Triazines; Tumor Necrosis Factor-alpha

2008
Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis.
    Arthritis research & therapy, 2008, Volume: 10, Issue:1

    Topics: Adjuvants, Immunologic; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cartilage, Articular; Collagen; Dose-Response Relationship, Drug; Enzyme Inhibitors; Interleukin-6; Janus Kinase 3; Male; Mice; Mice, Inbred DBA; Piperidines; Pyrimidines; Pyrroles; Rats; Rats, Inbred Lew

2008
Synthesis and pharmacological evaluation of a series of analgesic and antiinflammatory 4-aminopyrroles.
    Il Farmaco; edizione scientifica, 1984, Volume: 39, Issue:6

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Arthritis, Experimental; Carrageenan; Chemical Phenomena; Chemistry; Diarrhea; Edema; Lethal Dose 50; Male; Pyrroles; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Ulcer

1984
Anti-inflammatory and antiarthritic evaluation of acetaminophen and its potentiation of tolmetin.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:2

    Topics: Acetaminophen; Animals; Arthritis; Arthritis, Experimental; Drug Evaluation, Preclinical; Drug Therapy, Combination; Extremities; Female; Pyrroles; Radiography; Rats; Tolmetin

1983
The analgesic and anti-inflammatory profile of (+/-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2a]pyrrole-1-carboxylic acid (RS-37619).
    Agents and actions, 1982, Volume: 12, Issue:5-6

    Topics: Adrenal Cortex Hormones; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cardiovascular System; Central Nervous System; Digestive System; Edema; Granuloma; Ketorolac; Mice; Mice, Inbred Strains; Pain; Pyrroles; Rats; Rats, Inbred Strains; Tolmetin

1982
[Anti-inflammatory activity of a non-steroidal anti-inflammatory agent, zomepirac sodium, in experimental animals].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1982, Volume: 79, Issue:6

    Topics: Adrenalectomy; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Capillary Permeability; Depression, Chemical; Edema; Guinea Pigs; In Vitro Techniques; Male; Mice; Peptic Ulcer; Prostaglandins; Protein Denaturation; Pyrroles; Rabbits; Rats; Tolmetin

1982
Synthesis and biological activity of 5-(4-chlorobenzoyl)-4-(hydroxymethyl)-1-methyl-1H-pyrrole-2-acetic acid, a major metabolite of zomepirac sodium.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:1

    Topics: Analgesics; Animals; Arthritis, Experimental; Humans; In Vitro Techniques; Platelet Aggregation; Pyrroles; Rats; Stomach Ulcer; Tolmetin

1980
Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4- chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid.
    Arzneimittel-Forschung, 1995, Volume: 45, Issue:1

    Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Body Weight; Carrageenan; Cyclooxygenase Inhibitors; Edema; Female; Foot; Indomethacin; Male; Pyrroles; Rats; Rats, Wistar

1995
Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase.
    Arzneimittel-Forschung, 1994, Volume: 44, Issue:5

    Topics: Acetates; Animals; Arachidonic Acid; Arthritis, Experimental; Benzoquinones; Blood Coagulation; Bronchoconstriction; Carrageenan; Cyclooxygenase Inhibitors; Edema; Female; Guinea Pigs; In Vitro Techniques; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; Pain Measurement; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Rats; Rats, Sprague-Dawley; Yeast, Dried

1994
Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:2

    Topics: Administration, Oral; Amino Acid Sequence; Animals; Arthritis, Experimental; Female; Indoles; Lymphocyte Activation; Male; Mice; Molecular Sequence Data; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrroles; Rats; Rats, Inbred Lew; T-Lymphocytes

1994
Antiinflammatory 4,5-diarylpyrroles: synthesis and QSAR.
    Journal of medicinal chemistry, 1994, Apr-01, Volume: 37, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Disease Models, Animal; Drug Tolerance; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

1994
Effects of a protein kinase C inhibitor (PKCI) on the development of adjuvant-induced arthritis (AA) in rats.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44 Suppl 2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Experimental; Azepines; Enzyme Inhibitors; Indomethacin; Lymphocyte Activation; Male; Methotrexate; Protein Kinase C; Pyrroles; Rats; Rats, Inbred Lew

1995
Intercellular adhesion molecule-1 expression in adjuvant arthritis in rats: inhibition by kappa-opioid agonist but not by NSAID.
    The Journal of rheumatology, 1998, Volume: 25, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Female; Intercellular Adhesion Molecule-1; Naproxen; Narcotics; Pyrroles; Rats; Rats, Inbred Lew; Receptors, Opioid, kappa; Thiophenes

1998
6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2, 3-b]pyridine (RWJ 68354): a potent and selective p38 kinase inhibitor.
    Journal of medicinal chemistry, 1998, Oct-22, Volume: 41, Issue:22

    Topics: Aminopyridines; Animals; Arthritis, Experimental; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Humans; In Vitro Techniques; Interleukin-1; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Pyrroles; Rats; Rats, Inbred Lew; T-Lymphocytes; Tumor Necrosis Factor-alpha

1998
Pyrroles and other heterocycles as inhibitors of p38 kinase.
    Bioorganic & medicinal chemistry letters, 1998, Oct-06, Volume: 8, Issue:19

    Topics: Animals; Arthritis, Experimental; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Furans; Humans; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyrazoles; Pyrroles; Rats

1998
Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis.
    The Journal of rheumatology, 2001, Volume: 28, Issue:9

    Topics: Acetates; Animals; Arachidonate 5-Lipoxygenase; Arthritis, Experimental; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Lipoxygenase Inhibitors; Probability; Prostaglandin-Endoperoxide Synthases; Pyrroles; Range of Motion, Articular; Rats; Rats, Inbred Lew; Reference Values; Sensitivity and Specificity; Severity of Illness Index; Statistics, Nonparametric; Treatment Outcome

2001
Corticotropin releasing hormone (CRH) antagonist attenuates adjuvant induced arthritis: role of CRH in peripheral inflammation.
    The Journal of rheumatology, 2002, Volume: 29, Issue:6

    Topics: Animals; Arthritis, Experimental; Corticotropin-Releasing Hormone; Disease Models, Animal; Female; Immunohistochemistry; Male; Multivariate Analysis; Probability; Pyrimidines; Pyrroles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Receptors, Corticotropin-Releasing Hormone; Reference Values; Sensitivity and Specificity; Treatment Outcome

2002
Synthesis and anti-inflammatory properties of some pyrrolo(1H,3H)[3,4-d]pyrimidin-2-ones and pyrrolo(1H,6H)[3,4-d]pyrimidin-2-ones.
    Il Farmaco; edizione scientifica, 1979, Volume: 34, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Edema; Female; Indomethacin; Male; Mice; Pyrimidinones; Pyrroles; Rats

1979
Substituted 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-ones as potential antiinflammatory agents.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthus Reaction; Blood Platelets; Cyclooxygenase Inhibitors; Drug Evaluation; Humans; In Vitro Techniques; Lipoxygenase Inhibitors; Neutrophils; Pyridones; Pyrroles; Rats; Structure-Activity Relationship

1990
Profile of activity of a new anti-inflammatory agent, ST 679 (MED 15).
    Drugs under experimental and clinical research, 1990, Volume: 16, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Concanavalin A; Dose-Response Relationship, Drug; Drug Administration Schedule; Edema; Female; Glycine; Inflammation; Nystatin; Pyrroles; Rats; Rats, Inbred Strains

1990
Effect of tolmetin glycine amide (McN-4366), a prodrug of tolmetin sodium, on adjuvant arthritis in the rat.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3

    Topics: Animals; Arthritis; Arthritis, Experimental; Bone and Bones; Digestive System; Female; Indomethacin; Prodrugs; Pyrroles; Rats; Tolmetin

1988
Pharmacological study of the new nonsteroidal antiinflammatory agent 4'-acetamidophenyl-2-(5'-p-toluyl-1'-methylpyrrole)acetate.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Arthritis, Experimental; Carrageenan; Edema; Female; Gossypium; Guinea Pigs; Hemodynamics; Male; Mice; Platelet Aggregation; Psychomotor Performance; Pyrroles; Rats; Rats, Inbred Strains; Reaction Time; Stomach Ulcer; Tolmetin

1988