Page last updated: 2024-08-18

pyrroles and Acute Liver Injury, Drug-Induced

pyrroles has been researched along with Acute Liver Injury, Drug-Induced in 63 studies

Research

Studies (63)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (15.87)	18.7374
1990's	3 (4.76)	18.2507
2000's	17 (26.98)	29.6817
2010's	20 (31.75)	24.3611
2020's	13 (20.63)	2.80

Authors

Authors	Studies
Chan, WY; Li, M; Li, N; Lin, G; Ma, J	1
Isomoto, H; Kimura, R; Sugihara, T; Sugita, K; Yamamoto, O	1
Conway, C; Howell, BA; Siler, SQ; Watkins, PB; Woodhead, JL	1
Lai, X; Li, J; Li, W; Li, X; Zheng, J; Zhou, M	1
Abolghasemi, S; Mardani, M; Mohammadshahi, J; Teimourpour, R	1
Ankrom, W; Bondiskey, P; Dockendorf, MF; Jakate, A; Kraft, WK; Li, CC; Liu, W; Marcantonio, EE; Matthews, C; Mesens, S; Palcza, J; Panebianco, D; Reynders, T; Wagner, JA	1
Howell, BA; Pellegrini, L; Shoda, LKM; Woodhead, JL	1
Ailani, J; Butler, M; Finnegan, M; Hutchinson, S; Knievel, K; Lipton, RB; Lu, K; Severt, L; Trugman, JM; Yu, SY	1
Donati, DM; Longhi, A; Palmerini, E; Staals, EL	1
Boyko, M; Frank, D; Grinshpun, J; Gruenbaum, BF; Knyazer, B; Kuts, R; Melamed, I; Savir, S; Vinokur, M; Zlotnik, A	1
He, Y; Lin, G; Liu, J; Ma, J; Ye, Y; Zhang, C; Zhang, W; Zhu, L; Zhuge, Y	1
Baba, HA; Bauer, S; Choi, Y; Druta, M; Gelderblom, H; Healey, JH; Lewis, JH; Lin, CC; Pousa, AL; Shuster, DE; Stacchiotti, S; Tap, WD; van de Sande, M; Wagner, AJ; Wang, Q	1
Fu, PP; He, X; He, Y; Jia, W; Lin, G; Ma, J; Xia, Q; Zhang, C; Zhang, W; Zhu, L; Zhuge, Y	1
Fu, PP; Lin, G; Ma, J; Xia, Q	1
Chakravarthi, S; Haleagrahara, N; Judson, JP; Segarra, I; Tan, JR	1
El-Moselhy, MA; El-Sheikh, AA	1
Chang, CH; Chang, YC; Chuang, LM; Lee, YC; Lin, JW; Liu, YC	1
Bašić-Jukić, N; Ivandić, E	1
Chen, J; Gao, H; Ke, CQ; Li, N; Lin, G; Ruan, JQ; Wang, JY; Ye, Y	1
Fu, PP; Lin, G; Ruan, J; Yang, M	1
Fukuda, N; Fukushima, A; Inami, M; Matsumoto, Y; Moriyama, M; Soma, M; Tsunemi, A; Ueno, T; Yamada, T	1
Chen, J; Fu, PP; Gao, H; Ke, C; Li, N; Lin, G; Ruan, J; Wang, J; Xue, J; Ye, Y; Zheng, J	1
Chagin, K; Djousse, L; Fraeman, KH; Gagnon, DR; Hall, SA; Nelson, J; Nordstrom, BL; Shantakumar, S; van Herk-Sukel, M	1
Christophi, C; Fifis, T; Nguyen, L	1
Abraldes, JG; Arroyo, V; Bataller, R; Colmenero, J; Dominguez, M; Egido, J; Ginès, P; Moreno, M; Ramalho, F; Ramalho, LN; Ruiz-Ortega, M; Sancho-Bru, P	1
Bonnet, J; Davignon, J; Martineau, P; McPherson, R; Nozza, A; Simoneau, D; Tedgui, A	1
Akyurek, N; Benekli, M; Buyukberber, S; Coskun, U; Demirci, U; Karakan, T; Tonyali, O; Yildiz, R	1
Bonkovsky, HL; Russo, MW; Scobey, M	1
Adar, I; Golzman, G; Minha, S; Rapoport, M	1
Hu, Z; Li, S; Liao, M; Ma, H; Wang, Q; Wang, Y; Wu, C; Yang, B; Yuan, Y; Zheng, Z	1
Abd-Elghany, MI; Heeba, GH	1
Alencar, NM; Barboza, DR; Brito, GA; Gomes, AS; Leitão, RF; Macedo, RN; Medeiros, CA; Nogueira, NA; Ribeiro, RA	1
Akram, S; Chakravarthi, S; Judson, JP; Lim, AY; Segarra, I	1
Bruggisser, M; Haschke, M; Rätz Bravo, A; Terraciano, L	1
Anthoney, DA; Armand, JP; Balheda, R; Kroemer, G; Laffranchi, B; Massard, C; Pacciarini, MA; Pellizzoni, C; Proctor, A; Scaburri, A; Soria, JC; Twelves, CJ	1
Björnsson, E; Jacobsen, EI; Kalaitzakis, E	1
Hoekstra, R; Honeywell, RJ; Peters, GJ; van Erp, NP; Verheul, HM; Westgeest, HM	1
Lewin, JJ; Nappi, JM; Taylor, MH	1
Copple, BL; Ganey, PE; Hanumegowda, UM; Roth, RA; Shibuya, M; Yee, SB	1
Ceppa, P; Indiveri, F; Pelli, N; Setti, M; Toncini, C	1
DOWDLE, EB; EALES, L; SAUNDERS, SJ; SWEENEY, GD	1
Van Buuren, HR; Wolters, LM	1
Gibson, E; Luo, D; Newman, C; Szarek, M; Tsai, J	1
Baz, A; Clofent, J; de Castro, ML; de Luaces, C; Hermo, JA; Pérez, R	1
Blazing, M; Braunwald, E; Califf, R; Cannon, CP; de Lemos, JA; McCabe, CH; Murphy, SA; Wiviott, SD	1
Clarke, AT; Mills, PR	1
Becx, MC; Kuypers, KC; Seldenrijk, CA; Stolk, MF	1
Hey-Hadavi, JH; Kuntze, E; Lepetri, B; Luo, D; Pittman, D; Silverman, P	1
Guthrie, RM	1
Andrade, RJ; Barriocanal, A; Borraz, Y; Costa, J; Durán, JA; Fernández, MC; García-Cortés, M; García-Muņoz, B; Guarner, C; Hidalgo, R; Kaplowitz, N; Lucena, MI; Muņoz-Yagüe, T; Pachkoria, K; Pelaez, G; Planas, R; Rodrigo, L; Romero-Gomez, M; Salmerón, J	1
Alsheikh-Ali, AA; Karas, RH	1
Driver, HE; Mattocks, AR	1
Chiu, HF; Lee, SG; Lin, CC; Lin, JM; Yang, JJ	1
Bataille, L; Hamoir, V; Horsmans, Y; Nakad, A; Sempoux, C	1
Crook, MA; Wierzbicki, AS	1
Fanelli, V; Paolinelli, E; Piergiacomi, G	1
Ford, EJ	1
Schoental, R; Williams, AO	1
Richard, JL	1
Allen, JR; Chesney, CF	1
Mattocks, AR	1
Galambos, JT; Olansky, S; Vogler, WR	1
Gross, SR; Hutton, JJ	1

Reviews

8 review(s) available for pyrroles and Acute Liver Injury, Drug-Induced

Article	Year
Pexidartinib for the treatment of adult patients with symptomatic tenosynovial giant cell tumor: safety and efficacy. Expert review of anticancer therapy, 2020, Volume: 20, Issue:6 Topics: Adult; Aminopyridines; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Giant Cell Tumor of Tendon Sheath; Humans; Macrophage Colony-Stimulating Factor; Neoplasm Recurrence, Local; Pyrroles; Quality of Life	2020
Pyrrole-protein adducts - A biomarker of pyrrolizidine alkaloid-induced hepatotoxicity. Journal of food and drug analysis, 2018, Volume: 26, Issue:3 Topics: Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Humans; Liver; Proteins; Pyrroles; Pyrrolizidine Alkaloids	2018
Drug-induced liver injury associated with statins. Seminars in liver disease, 2009, Volume: 29, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Atorvastatin; Autoimmunity; Biomarkers; Biopsy; Chemical and Drug Induced Liver Injury; Chronic Disease; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Liver; Liver Diseases; Male; Middle Aged; Practice Guidelines as Topic; Pyrroles; Risk Assessment; Treatment Outcome; Young Adult	2009
Comparative safety of atorvastatin 80 mg versus 10 mg derived from analysis of 49 completed trials in 14,236 patients. The American journal of cardiology, 2006, Jan-01, Volume: 97, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Albuminuria; Aspartate Aminotransferases; Atorvastatin; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Utilization; Female; Hematuria; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Muscular Diseases; Pain; Pyrroles; Retrospective Studies	2006
Atorvastatin associated liver disease. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2006, Volume: 38, Issue:10 Topics: Aged; Atorvastatin; Chemical and Drug Induced Liver Injury; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver Function Tests; Male; Middle Aged; Pyrroles	2006
Tolerability of atorvastatin in a population aged > or =65 years: a retrospective pooled analysis of results from fifty randomized clinical trials. The American journal of geriatric pharmacotherapy, 2006, Volume: 4, Issue:2 Topics: Aged; Anticholesteremic Agents; Atorvastatin; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Kidney Diseases; Male; Musculoskeletal Diseases; Pyrroles; Randomized Controlled Trials as Topic; Retrospective Studies	2006
How safe is aggressive statin therapy? Progress in cardiovascular nursing, 2006,Summer, Volume: 21, Issue:3 Topics: Atorvastatin; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Fluorobenzenes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Muscular Diseases; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Simvastatin; Sulfonamides	2006
Mycotoxin photosensitivity. Journal of the American Veterinary Medical Association, 1973, Dec-01, Volume: 163, Issue:11 Topics: Animal Feed; Animals; Cattle; Cattle Diseases; Chemical and Drug Induced Liver Injury; Cholestasis; Eczema; Indoles; Liver Diseases; Medicago sativa; Mitosporic Fungi; Mycotoxins; Photosensitivity Disorders; Pyrazines; Pyrroles; Sheep; Sheep Diseases; United States	1973

Trials

4 trial(s) available for pyrroles and Acute Liver Injury, Drug-Induced

Article	Year
Ubrogepant Is Not Associated With Clinically Meaningful Elevations of Alanine Aminotransferase in Healthy Adult Males. Clinical and translational science, 2020, Volume: 13, Issue:3 Topics: Adolescent; Adult; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Healthy Volunteers; Humans; Liver Function Tests; Male; Middle Aged; Migraine Disorders; Pyridines; Pyrroles; Reference Values; Young Adult	2020
Long-Term Safety Evaluation of Ubrogepant for the Acute Treatment of Migraine: Phase 3, Randomized, 52-Week Extension Trial. Headache, 2020, Volume: 60, Issue:1 Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Calcitonin Gene-Related Peptide Receptor Antagonists; Chemical and Drug Induced Liver Injury; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Middle Aged; Migraine Disorders; Pyridines; Pyrroles	2020
Comparative effects of 10-mg versus 80-mg Atorvastatin on high-sensitivity C-reactive protein in patients with stable coronary artery disease: results of the CAP (Comparative Atorvastatin Pleiotropic effects) study. Clinical therapeutics, 2008, Volume: 30, Issue:12 Topics: Adult; Anticholesteremic Agents; Atorvastatin; C-Reactive Protein; Canada; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Cholesterol, HDL; Cholesterol, LDL; Coronary Artery Disease; Dose-Response Relationship, Drug; Double-Blind Method; Europe; Female; Heptanoic Acids; Humans; Male; Prospective Studies; Pyrroles; Time Factors; Treatment Outcome; Triglycerides	2008
A first in man, phase I dose-escalation study of PHA-793887, an inhibitor of multiple cyclin-dependent kinases (CDK2, 1 and 4) reveals unexpected hepatotoxicity in patients with solid tumors. Cell cycle (Georgetown, Tex.), 2011, Mar-15, Volume: 10, Issue:6 Topics: Adult; Aged; Antineoplastic Agents; CDC2 Protein Kinase; Chemical and Drug Induced Liver Injury; Cohort Studies; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Neoplasms; Protein Kinase Inhibitors; Pyrazoles; Pyrroles	2011

Other Studies

51 other study(ies) available for pyrroles and Acute Liver Injury, Drug-Induced

Article	Year
Pyrrolizidine Alkaloid-Induced Hepatotoxicity Associated with the Formation of Reactive Metabolite-Derived Pyrrole-Protein Adducts. Toxins, 2021, 10-13, Volume: 13, Issue:10 Topics: Alanine Transaminase; Animals; Asteraceae; Chemical and Drug Induced Liver Injury; Crotalaria; Liver; Male; Plant Extracts; Proteins; Pyrroles; Pyrrolizidine Alkaloids; Rats, Sprague-Dawley	2021
Treatment of Digital Ulcers and Reflux Oesophagitis in a Patient with Systemic Sclerosis: Increased Risk of Hepatotoxicity due to a Potential Drug-drug Interaction Between Bosentan and Vonoprazan. Acta dermato-venereologica, 2021, Nov-24, Volume: 101, Issue:11 Topics: Bosentan; Chemical and Drug Induced Liver Injury; Drug Interactions; Esophagitis, Peptic; Humans; Pharmaceutical Preparations; Pyrroles; Scleroderma, Systemic; Sulfonamides; Ulcer	2021
Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling. Toxicological sciences : an official journal of the Society of Toxicology, 2022, 06-28, Volume: 188, Issue:1 Topics: Azepines; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Chemical and Drug Induced Liver Injury; Computer Simulation; Drug-Related Side Effects and Adverse Reactions; Humans; Imidazoles; Piperidines; Pyridines; Pyrroles; Spiro Compounds	2022
Evaluating and predicting the correlations of hepatic concentration and pyrrole-protein adduction with hepatotoxicity induced by retrorsine based on pharmacokinetic/pharmacodynamic model. Toxicology letters, 2023, Jan-15, Volume: 373 Topics: Animals; Chemical and Drug Induced Liver Injury; Liver; Mice; Proteins; Pyrroles; Pyrrolizidine Alkaloids	2023
Drug-induced liver injury due to tofacitinib: a case report. Journal of medical case reports, 2023, Mar-18, Volume: 17, Issue:1 Topics: Adolescent; Alopecia Areata; Chemical and Drug Induced Liver Injury; Female; Humans; Iran; Protein Kinase Inhibitors; Pyrroles	2023
Comparison of the Hepatotoxic Potential of Two Treatments for Autosomal-Dominant Polycystic Kidney DiseaseUsing Quantitative Systems Toxicology Modeling. Pharmaceutical research, 2020, Jan-06, Volume: 37, Issue:2 Topics: Benzamides; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Humans; Models, Theoretical; Polycystic Kidney, Autosomal Dominant; Pyrroles; Tolvaptan	2020
Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube. Journal of visualized experiments : JoVE, 2020, 04-28, Issue:158 Topics: Acute Disease; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Intubation, Gastrointestinal; Liver; Male; Pyrroles; Rats	2020
Clinical application of pyrrole-hemoglobin adducts as a biomarker of pyrrolizidine alkaloid exposure in humans. Archives of toxicology, 2021, Volume: 95, Issue:2 Topics: Activation, Metabolic; Adult; Aged; Aged, 80 and over; Biomarkers; Blood Proteins; Chemical and Drug Induced Liver Injury; Female; Hemoglobins; Humans; Kinetics; Liver; Male; Middle Aged; Pyrroles; Pyrrolizidine Alkaloids	2021
Pexidartinib Long-Term Hepatic Safety Profile in Patients with Tenosynovial Giant Cell Tumors. The oncologist, 2021, Volume: 26, Issue:5 Topics: Aminopyridines; Chemical and Drug Induced Liver Injury; Giant Cell Tumor of Tendon Sheath; Humans; Liver; Pyrroles	2021
Developing urinary pyrrole-amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human. Archives of toxicology, 2021, Volume: 95, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Amino Acids; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Female; Humans; Male; Middle Aged; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Sprague-Dawley; Time Factors	2021
Potential protective effect of sunitinib after administration of diclofenac: biochemical and histopathological drug-drug interaction assessment in a mouse model. Naunyn-Schmiedeberg's archives of pharmacology, 2013, Volume: 386, Issue:7 Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspartate Aminotransferases; Blood Urea Nitrogen; Brain; Chemical and Drug Induced Liver Injury; Creatinine; Diclofenac; Drug Interactions; Indoles; Kidney; Liver; Male; Mice; Mice, Inbred ICR; Myocardium; Protective Agents; Protein Kinase Inhibitors; Pyrroles; Spleen; Sunitinib	2013
Protective mechanisms of atorvastatin against doxorubicin-induced hepato-renal toxicity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2014, Volume: 68, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antioxidants; Apoptosis; Atorvastatin; Chemical and Drug Induced Liver Injury; Down-Regulation; Doxorubicin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Diseases; Male; Nitric Oxide; Oxidative Stress; Pyrroles; Rats; Rats, Wistar; Up-Regulation	2014
Severe hepatic injury associated with different statins in patients with chronic liver disease: a nationwide population-based cohort study. Journal of gastroenterology and hepatology, 2015, Volume: 30, Issue:1 Topics: Adult; Aged; Atorvastatin; Chemical and Drug Induced Liver Injury; Chronic Disease; Cohort Studies; Follow-Up Studies; Heptanoic Acids; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Liver Diseases; Male; Middle Aged; Pyrroles; Risk; Severity of Illness Index; Taiwan; Time Factors	2015
[Liver damage caused by atorvastatin and cyclosporine in patients with renal transplant]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti, 2014, Volume: 68, Issue:2 Topics: Atorvastatin; Chemical and Drug Induced Liver Injury; Cyclosporine; Graft Rejection; Graft Survival; Heptanoic Acids; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Transplantation; Liver; Male; Middle Aged; Pyrroles	2014
Blood pyrrole-protein adducts as a diagnostic and prognostic index in pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome. Drug design, development and therapy, 2015, Volume: 9 Topics: Adult; Aged; Biomarkers; Blood Proteins; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Female; Hepatic Veno-Occlusive Disease; Humans; Linear Models; Male; Middle Aged; Predictive Value of Tests; Prognosis; Prospective Studies; Pyrroles; Pyrrolizidine Alkaloids; Severity of Illness Index; Tandem Mass Spectrometry	2015
Cytotoxicity of pyrrolizidine alkaloid in human hepatic parenchymal and sinusoidal endothelial cells: Firm evidence for the reactive metabolites mediated pyrrolizidine alkaloid-induced hepatotoxicity. Chemico-biological interactions, 2016, Jan-05, Volume: 243 Topics: Chemical and Drug Induced Liver Injury; Cytotoxins; Endothelial Cells; Hep G2 Cells; Humans; Liver; Proteins; Pyrroles; Pyrrolizidine Alkaloids	2016
Reduction of Dimethylnitrosamine-Induced Liver Fibrosis by the Novel Gene Regulator PI Polyamide Targeting Transforming Growth Factor β1 Gene. Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:12 Topics: Actins; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; End Stage Liver Disease; Fibrosis; Gene Silencing; Hepatic Stellate Cells; Imidazoles; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Male; Matrix Metalloproteinase 2; Pyrroles; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta	2015
Blood Pyrrole-Protein Adducts--A Biomarker of Pyrrolizidine Alkaloid-Induced Liver Injury in Humans. Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews, 2015, Volume: 33, Issue:4 Topics: Adolescent; Adult; Aged; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Female; Hepatic Veno-Occlusive Disease; Humans; Male; Middle Aged; Pyrroles; Pyrrolizidine Alkaloids; Rats; Toxicity Tests; Toxins, Biological	2015
Occurrence of hepatotoxicity with pazopanib and other anti-VEGF treatments for renal cell carcinoma: an observational study utilizing a distributed database network. Cancer chemotherapy and pharmacology, 2016, Volume: 78, Issue:3 Topics: Aged; Antineoplastic Agents; Bevacizumab; Carcinoma, Renal Cell; Chemical and Drug Induced Liver Injury; Cohort Studies; Computer Communication Networks; Female; Follow-Up Studies; Humans; Indazoles; Indoles; Kidney Neoplasms; Male; Middle Aged; Niacinamide; Phenylurea Compounds; Pyrimidines; Pyrroles; Retrospective Studies; Sorafenib; Sulfonamides; Sunitinib; Vascular Endothelial Growth Factor A	2016
Vascular disruptive agent OXi4503 and anti-angiogenic agent Sunitinib combination treatment prolong survival of mice with CRC liver metastasis. BMC cancer, 2016, 07-26, Volume: 16 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cadherins; Chemical and Drug Induced Liver Injury; Colorectal Neoplasms; Diphosphates; Epithelial-Mesenchymal Transition; Humans; Indoles; Liver Neoplasms; Male; Mice; Mice, Inbred CBA; Protein Kinase Inhibitors; Pyrroles; Stilbenes; Sunitinib; Vimentin; Xenograft Model Antitumor Assays; Zinc Finger E-box-Binding Homeobox 1	2016
Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver. American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 296, Issue:2 Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Atorvastatin; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Hepatic Stellate Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Infusion Pumps, Implantable; Intercellular Adhesion Molecule-1; Interleukin-6; Liver; Male; Oxidative Stress; Pyrroles; Rats; Rats, Wistar; Transforming Growth Factor beta1	2009
Imatinib mesylate-induced acute liver failure in a patient with gastrointestinal stromal tumors. Medical oncology (Northwood, London, England), 2010, Volume: 27, Issue:3 Topics: Acute Disease; Anti-Inflammatory Agents; Antineoplastic Agents; Benzamides; Chemical and Drug Induced Liver Injury; Female; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Intestinal Neoplasms; Liver; Liver Failure; Middle Aged; Peritoneal Neoplasms; Piperazines; Prednisolone; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Sunitinib	2010
Cholestatic jaundice induced by atorvastatin: a possible association with antimitochondrial antibodies. The Israel Medical Association journal : IMAJ, 2009, Volume: 11, Issue:7 Topics: Aged; Atorvastatin; Autoantibodies; Chemical and Drug Induced Liver Injury; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Jaundice, Obstructive; Male; Mitochondria; Pyrroles	2009
Plasma and liver proteomic analysis of 3Z-3-[(1H-pyrrol-2-yl)-methylidene]-1-(1-piperidinylmethyl)-1,3-2H-indol-2-one-induced hepatotoxicity in Wistar rats. Proteomics, 2010, Volume: 10, Issue:16 Topics: Amino Acids; Animals; Apoptosis; Blood Proteins; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Female; Histocytochemistry; In Situ Nick-End Labeling; Liver; Mass Spectrometry; Mesylates; NADP; Proteome; Proteomics; Pyrroles; Rats; Rats, Wistar; Reactive Oxygen Species	2010
Effect of combined administration of ginger (Zingiber officinale Roscoe) and atorvastatin on the liver of rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2010, Dec-01, Volume: 17, Issue:14 Topics: Animals; Anti-Inflammatory Agents; Anticholesteremic Agents; Antioxidants; Atorvastatin; Catalase; Chemical and Drug Induced Liver Injury; Cholesterol; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Heptanoic Acids; Liver; Male; Malondialdehyde; Nitric Oxide; Phytotherapy; Plant Extracts; Pyrroles; Random Allocation; Rats; Rats, Wistar; Rhizome; Superoxide Dismutase; Transaminases; Vitamin E; Zingiber officinale	2010
Effect of atorvastatin on 5-fluorouracil-induced experimental oral mucositis. Cancer chemotherapy and pharmacology, 2011, Volume: 67, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Atorvastatin; Bacteremia; Chemical and Drug Induced Liver Injury; Cricetinae; Cytokines; Dose-Response Relationship, Drug; Fluorouracil; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukopenia; Male; Mesocricetus; Mouth Mucosa; Nitric Oxide Synthase Type II; Nitrites; Peroxidase; Pyrroles; Stomatitis; Sulfhydryl Compounds	2011
Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice. BMC pharmacology, 2010, Oct-15, Volume: 10 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antineoplastic Agents; Antipyretics; Biomarkers; Brain; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Interactions; Hyperemia; Indoles; Kidney; Liver; Male; Mice; Mice, Inbred ICR; Necrosis; Protein Kinase Inhibitors; Pyrroles; Random Allocation; Sunitinib	2010
[Liver damage in a patient treated with a vitamin K antagonist, a statin and an ACE inhibitor]. Praxis, 2010, Oct-20, Volume: 99, Issue:21 Topics: Administration, Oral; Aged; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Atorvastatin; Biopsy; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug Therapy, Combination; Hematuria; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Function Tests; Male; Perindopril; Phenprocoumon; Pyrroles; Vitamin K	2010
Hepatotoxicity associated with statins: reports of idiosyncratic liver injury post-marketing. Journal of hepatology, 2012, Volume: 56, Issue:2 Topics: Adverse Drug Reaction Reporting Systems; Aged; Atorvastatin; Chemical and Drug Induced Liver Injury; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pyrroles; Simvastatin; Sweden; Time Factors	2012
Successful treatment of renal cell carcinoma with sorafenib after effective but hepatotoxic sunitinib exposure. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Feb-20, Volume: 31, Issue:6 Topics: Aged; Angiogenesis Inhibitors; Antineoplastic Agents; Carcinoma, Renal Cell; Chemical and Drug Induced Liver Injury; Humans; Indoles; Liver Neoplasms; Male; Niacinamide; Phenylurea Compounds; Pyrroles; Sorafenib; Sunitinib; Treatment Outcome	2013
Rhabdomyolysis with concurrent atorvastatin and diltiazem. The Annals of pharmacotherapy, 2002, Volume: 36, Issue:10 Topics: Acute Disease; Acute Kidney Injury; Atorvastatin; Cardiovascular Agents; Chemical and Drug Induced Liver Injury; Diltiazem; Drug Interactions; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pyrroles; Rhabdomyolysis	2002
Endothelial cell injury and coagulation system activation during synergistic hepatotoxicity from monocrotaline and bacterial lipopolysaccharide coexposure. Toxicological sciences : an official journal of the Society of Toxicology, 2003, Volume: 74, Issue:1 Topics: Animals; Blood Coagulation; Chemical and Drug Induced Liver Injury; Drug Synergism; Endothelial Cells; Fibrin; Fibrinogen; Hemoglobins; Immunoblotting; Immunohistochemistry; Lipopolysaccharides; Male; Microscopy, Electron, Scanning; Microsomes, Liver; Monocrotaline; Poisons; Pyrroles; Rats; Rats, Sprague-Dawley	2003
Autoimmune hepatitis revealed by atorvastatin. European journal of gastroenterology & hepatology, 2003, Volume: 15, Issue:8 Topics: Aged; Alanine Transaminase; Aspartate Aminotransferases; Atorvastatin; Autoimmune Diseases; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Function Tests; Pyrroles	2003
EFFECTS OF CHLOROQUINE ON PATIENTS WITH CUTANEOUS PORPHYRIA OF THE "SYMPTOMATIC" TYPE. British medical journal, 1965, May-15, Volume: 1, Issue:5445 Topics: Amino Acids; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chloroquine; Classification; Clinical Enzyme Tests; Fluids and Secretions; Glucosephosphate Dehydrogenase Deficiency; Glucosephosphates; Hepatitis; Humans; Levulinic Acids; Liver; Metabolism; Pathology; Porphyrias; Porphyrins; Pyrroles; Toxicology; Urine	1965
Rosuvastatin-associated hepatitis with autoimmune features. European journal of gastroenterology & hepatology, 2005, Volume: 17, Issue:5 Topics: Anticholesteremic Agents; Atorvastatin; Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Female; Heptanoic Acids; Humans; Middle Aged; Pyrroles	2005
[Acute cholestatic hepatitis after atorvastatin reintroduction]. Gastroenterologia y hepatologia, 2006, Volume: 29, Issue:1 Topics: Acute Disease; Aged; Atorvastatin; Chemical and Drug Induced Liver Injury; Cholestasis; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pyrroles	2006
A tale of two trials: a comparison of the post-acute coronary syndrome lipid-lowering trials A to Z and PROVE IT-TIMI 22. Circulation, 2006, Mar-21, Volume: 113, Issue:11 Topics: Aged; Angina, Unstable; Atorvastatin; C-Reactive Protein; Cardiovascular Diseases; Case Management; Chemical and Drug Induced Liver Injury; Comorbidity; Confounding Factors, Epidemiologic; Dose-Response Relationship, Drug; Endpoint Determination; Female; Heptanoic Acids; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Life Tables; Lipids; Male; Middle Aged; Multicenter Studies as Topic; Myocardial Infarction; Myocardial Ischemia; Myocardial Revascularization; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Research Design; Risk; Risk Factors; Simvastatin; Stroke; Tirofiban; Treatment Outcome; Tyrosine	2006
Severe hepatic side effects of ezetimibe. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2006, Volume: 4, Issue:7 Topics: Anticholesteremic Agents; Atorvastatin; Azetidines; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Ezetimibe; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Liver Diseases; Male; Middle Aged; Pyrroles; Transaminases	2006
Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry. Hepatology (Baltimore, Md.), 2006, Volume: 44, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Amoxicillin-Potassium Clavulanate Combination; Atorvastatin; Azepines; Captopril; Cardiovascular Agents; Central Nervous System Agents; Chemical and Drug Induced Liver Injury; Chronic Disease; Disease Progression; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Heptanoic Acids; Humans; Liver; Liver Diseases; Male; Middle Aged; Pyrroles; Registries; Spain	2006
Safety of lovastatin/extended release niacin compared with lovastatin alone, atorvastatin alone, pravastatin alone, and simvastatin alone (from the United States Food and Drug Administration adverse event reporting system). The American journal of cardiology, 2007, Feb-01, Volume: 99, Issue:3 Topics: Adverse Drug Reaction Reporting Systems; Atorvastatin; Chemical and Drug Induced Liver Injury; Drug Prescriptions; Drug Therapy, Combination; Dyslipidemias; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Liver Diseases; Lovastatin; Niacin; Pravastatin; Prevalence; Pyrroles; Retrospective Studies; Rhabdomyolysis; Risk Factors; Simvastatin; United States; United States Food and Drug Administration	2007
The toxic effects in rats of some synthanecine carbamate and phosphate esters analogous to hepatotoxic pyrrolizidine alkaloids. Chemico-biological interactions, 1984, Sep-15, Volume: 51, Issue:2 Topics: Alkaloids; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Kidney; Lethal Dose 50; Liver; Lung; Male; Myocardium; Necrosis; Phenobarbital; Pyrroles; Pyrrolizidine Alkaloids; Rats; Structure-Activity Relationship; Time Factors	1984
Evaluation of the anti-inflammatory and liver-protective effects of anoectochilus formosanus, ganoderma lucidum and gynostemma pentaphyllum in rats. The American journal of Chinese medicine, 1993, Volume: 21, Issue:1 Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Biopsy; Carbon Tetrachloride; Carrageenan; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Edema; Liver Diseases; Male; Pyrroles; Rats; Rats, Wistar	1993
Atorvastatin-induced acute hepatitis with absence of cross-toxicity with simvastatin. Lancet (London, England), 1999, May-22, Volume: 353, Issue:9166 Topics: Aged; Anticholesteremic Agents; Atorvastatin; Chemical and Drug Induced Liver Injury; Drug Interactions; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Pyrroles; Simvastatin	1999
Cholestatic liver dysfunction. Lancet (London, England), 1999, Sep-11, Volume: 354, Issue:9182 Topics: Anticholesteremic Agents; Atorvastatin; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Diagnosis, Differential; Heptanoic Acids; Humans; Liver Function Tests; Male; Middle Aged; Pyrroles	1999
[Hepatotoxicity of non-steroidal anti-inflammatory drugs]. La Clinica terapeutica, 1985, Apr-15, Volume: 113, Issue:1 Topics: Anti-Inflammatory Agents; Aspirin; Chemical and Drug Induced Liver Injury; Child; Female; Humans; Indoles; Liver; Liver Function Tests; Male; Middle Aged; Phenylacetates; Phenylpropionates; Pyrazoles; Pyrroles; Salicylates; Sulindac	1985
Activity of gamma-glutamyl transpeptidase and other enzymes in the serum of sheep with liver or kidney damage. Journal of comparative pathology, 1974, Volume: 84, Issue:2 Topics: Alcohol Oxidoreductases; Animals; Arginase; Aspartate Aminotransferases; Bilirubin; Brain; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Female; gamma-Glutamyltransferase; Glutamate Dehydrogenase; Indoles; Intestine, Small; Kidney; Kidney Diseases; Ligation; Liver; Liver Diseases; Male; Mercury Poisoning; Muscles; Mycotoxins; Myocardium; Pancreas; Pyrazines; Pyrroles; Sheep; Sheep Diseases; Urea	1974
Hepatotoxicity of Senecio abyssinicus. Experimental and ultrastructural studies. Tropical and geographical medicine, 1970, Volume: 22, Issue:2 Topics: Aflatoxins; Alkaloids; Animals; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diet; Folklore; Liver; Liver Neoplasms; Male; Microscopy, Electron; Nigeria; Plants, Toxic; Pyrroles; Rats; Senecio; Staining and Labeling	1970
Effect of age on development of cor pulmonale in nonhuman primates following pyrrolizidine alkaloid intoxication. Experimental and molecular pathology, 1972, Volume: 17, Issue:2 Topics: Age Factors; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Enzymes; Female; Formaldehyde; Haplorhini; Hepatic Veins; Injections, Subcutaneous; Liver; Liver Diseases; Lung; Macaca; Male; Microsomes, Liver; Myocardium; Necrosis; Pulmonary Artery; Pulmonary Heart Disease; Pyrroles; Pyrrolizidine Alkaloids	1972
Acute hepatotoxicity and pyrrolic metabolites in rats dosed with pyrrolizidine alkaloids. Chemico-biological interactions, 1972, Volume: 5, Issue:4 Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Lethal Dose 50; Liver; Male; Microsomes, Liver; Phenobarbital; Proadifen; Pyrroles; Pyrrolizidine Alkaloids; Rats; Sucrose; Tissue Extracts	1972
Biochemical effects of chloroquine therapy in porphyria cutanea tarda. The American journal of medicine, 1970, Volume: 49, Issue:3 Topics: Ascites; Body Temperature; Chemical and Drug Induced Liver Injury; Chloroquine; Chromatography; Feces; Female; Hematologic Diseases; Humans; Iron; Levulinic Acids; Liver Function Tests; Male; Middle Aged; Porphyrias; Porphyrins; Propionates; Pyrroles; Time Factors	1970
Chemical induction of hepatic porphyria in inbred strains of mice. Archives of biochemistry and biophysics, 1970, Volume: 141, Issue:1 Topics: Acyltransferases; Amino Acids; Animals; Chemical and Drug Induced Liver Injury; Feedback; Female; Genotype; Hydro-Lyases; Inbreeding; Levulinic Acids; Liver; Liver Diseases; Lyases; Mice; Porphyrias; Porphyrins; Propionates; Pyridines; Pyrroles; Succinates	1970