pyrophosphate and Uterine-Neoplasms

Angioscintigraphy was used for examination of 128 patients, of them 91 had tumors of the genital organs, 22 inflammatory adnexal processes and 15 various extragenital diseases. Statistical scintigraphy was performed 5-40 min. after RP intravenous injection at 175-555 MBq. RP injection was followed by dynamic studies, the rate of recording being 1 frame per min. An anterioposterior direct projection with alignment of a gamma-chamber detector over the small pelvic area was used. 99mTc-human serum albumin and erythrocytes labeled in vivo with 99mTc-pyrophosphate served as radioactive markers of the blood pool. A scintigraphic picture in normal and pathology (tumors and inflammatory processes) in the uterus and appendages had characteristics features. Data on a degree of tumor vascularization could be used for recognition of disease as well as for adequate assessment of therapeutic efficacy. The sensitivity of the method was 97%, its specificity--59%, its accuracy--88%.

Topics: Adnexa Uteri; Adolescent; Adult; Aged; Diagnosis, Differential; Diphosphates; Female; Humans; Leiomyoma; Middle Aged; Ovarian Cysts; Pelvic Inflammatory Disease; Radionuclide Imaging; Technetium; Technetium Tc 99m Aggregated Albumin; Technetium Tc 99m Pyrophosphate; Uterine Neoplasms; Uterus

Staging bone scans or skeletal surveys were obtained of 97 patients with endometrial carcinoma. Of the 77 patients with Stage I or II disease, no metastases were identified at staging. Three patients in the entire series demonstrated bony metastases; all of these metastases were detectable by radionuclide bone scan and radiographic bone survey. Eighty-nine patients were examined with radionuclide liver/spleen scanning at the time of staging. Four of the 89 initial scans were interpreted as demonstrating hepatocellular disease, and all four patients had abnormal liver function studies. Only one patient demonstrated a possible hepatic metastasis at initial diagnosis. This patient also had abnormal liver function studies. Based on these results, bone surveys and radionuclide bone scans are not indicated as screening procedures in endometrial carcinoma. It is suggested that screening for liver metastases in patients with endometrial carcinoma is not warranted in patients with normal liver function studies.

Topics: Bone Neoplasms; Carcinoma; Diphosphates; Diphosphonates; Female; Humans; Liver Neoplasms; Neoplasm Staging; Radionuclide Imaging; Sulfur; Technetium; Technetium Tc 99m Medronate; Technetium Tc 99m Sulfur Colloid; Uterine Neoplasms