pyrophosphate and Tooth-Discoloration

The market for whitening toothpastes in the UK is burgeoning at present, but little has been published about the modes of action or efficacy of such pastes. Much is known about how the individual ingredients work, but toothpaste formulations are complex and there is potential for interaction. Studies have been undertaken to compare the efficacy of various test products, but these have used different types of trial design and consequently direct comparisons are difficult, not least because there are several ways of measuring 'whiteness', and there is no consensus of opinion between workers in this field as to the best way to record it.

Topics: Anti-Infective Agents, Local; Consumer Product Safety; Detergents; Diphosphates; Drug Combinations; Enzyme Therapy; Humans; Oxidants; Tooth Bleaching; Tooth Discoloration; Toothpastes

Dental stains can be broadly classified as intrinsic or extrinsic. Intrinsic stains are a result of defects in tooth development, fluorosis, or acquired through the use of tetracycline. Extrinsic stains are localized mainly in the pellicle and are generated by the reaction between sugars and amino acids or acquired from the retention of exogenous chromophores in the pellicle. Three clinical methods are currently used for measuring stain removal and tooth whitening in the development of new whitening technologies: Lobene Stain Index, Shade Guide Color Change, and Minolta ChromaMeter. Professional tooth whitening products rely on proven technologies--35% hydrogen peroxide for in-office power bleaching or 10% to 15% carbamide peroxide for at-home bleaching--to reduce intrinsic stain and change the inherent tooth color. Over-the-counter tooth whitening products use a combination of surfactants, abrasives, anticalculus agents, and low levels of hydrogen peroxide to reduce extrinsic stain and help maintain tooth whiteness after professional treatment. Future technologies for whitening teeth could involve the use of activating agents to enhance the performance of hydrogen peroxide and natural enzymes.

Topics: Color; Dental Deposits; Dental Pellicle; Dentifrices; Diphosphates; Fluorides; Food; Gluconates; Humans; Maillard Reaction; Outcome Assessment, Health Care; Oxidants; Peroxides; Surface-Active Agents; Tooth Bleaching; Tooth Discoloration

To assess the effects for controlling extrinsic tooth stain of a whitening toothpaste containing 10% high cleaning silica, 0.5% sodium phytate and 0.5% sodium pyrophosphate, in comparison with a negative control toothpaste.. A total of 86 adults who met with the inclusion and exclusion criteria were invited to take part in the study. They were distributed into test and control groups randomly. At baseline, 4 weeks and 8 weeks, the same examiner provided the clinical examinations, including evaluations of oral soft and hard tissues and measurements of tooth stain of the anterior teeth using the Lobene Stain Index. Adverse events and any changes in general health conditions of the patients were monitored.. When the study was completed, comparisons between patients in test and control groups yielded statistically significant differences in Lobene stain adjusted mean area score [0.83 (0.05) vs. 1.13 (0.05)], Lobene stain adjusted mean intensity score [0.99 (0.06) vs. 1.32 (0.06)] and Lobene stain adjusted mean composite score [1.45 (0.13) vs. 2.50 (0.13)] (All, P < 0.001). Patients in the test group exhibited reductions of 26.55%, 25% and 42%, respectively in Lobene stain area, intensity and composite scores, relative to patients in the control group. Comparisons within groups showed that all three Lobene scores at 8 weeks in both groups were lower than those at baseline (All, P < 0.001).. This study demonstrates that 8-week use of a toothpaste containing 10% high cleaning silica, 0.5% sodium phytate and 0.5% sodium pyrophosphate can effectively reduce extrinsic tooth stain. Trial registration NCT04238429 (before enrollment of the first participant). Data register: March 4, 2018.

Topics: Adult; Dentifrices; Diphosphates; Humans; Phytic Acid; Silicon Dioxide; Sodium Fluoride; Tooth Bleaching; Tooth Discoloration; Toothpastes; Treatment Outcome

The primary purpose of this randomized, controlled, six-week clinical trial was to determine the effectiveness and safety of a new whitening dentifrice in removing extrinsic tooth stain and whitening teeth. An additional two-week exploratory study was conducted to determine whether the whitening or stain-prevention activity of the dentifrice would persist following cessation of use.. In the first study (Phase I), one-hundred and forty-six qualifying subjects were randomly assigned to either a sodium bicarbonate whitening dentifrice group (Arm & Hammer Advance White Extreme Whitening Baking Soda and Peroxide Toothpaste) or a silica-based negative control dentifrice group, and brushed twice daily with their assigned dentifrice for six weeks. Tooth shade on the labial surfaces of the eight incisors was assessed using a Vita Classic shade guide, and extrinsic tooth stain was scored using a Modified Lobene Stain Index (MLSI) at baseline, week 4, and week 6. In Phase II (after the week 6 examination), volunteers from the Arm & Hammer whitening dentifrice group were randomly assigned to continue using the whitening dentifrice or to use the negative control dentifrice twice daily for two weeks. The six-week shade and stain index scores served as the baseline for this exploratory phase and were rescored after two weeks.. The whitening dentifrice group had statistically significant (p < 0.0001) mean shade score reductions of 1.82 and 2.57 from baseline to weeks 4 and 6, respectively. For the same periods, the negative control dentifrice group was virtually unchanged from baseline. For tooth stain, the MLSI total mean scores for the whitening dentifrice group showed statistically significant (p < 0.0001) decreases from baseline of 1.42 (41.6%) and 2.11 (61.6%) at weeks 4 and 6, respectively. In contrast, the negative control dentifrice group had a MLSI reduction of 0.07 at week 4 and a 0.06 increase at week 6. Between-group analyses using baseline-adjusted ANCOVA showed the whitening dentifrice to be statistically significantly more effective (p < 0.0001) than the negative control for shade and tooth stain reductions for all index comparisons. Compared to the six-week (baseline) scores, subjects who continued to use the whitening dentifrice for the additional two weeks experienced statistically significant (p < 0.0001) further mean reductions of 0.88 in shade score and 0.46 in MLSI score, while subjects who switched to the negative control dentifrice experienced smaller, statistically significant (p < 0.05) reductions of 0.34 in shade score and 0.13 in total MLSI score.. The Arm & Hammer whitening dentifrice tested in this study is effective for removing extrinsic tooth stain and whitening teeth. While the results also suggest that this dentifrice may have stain-prevention activity that persists following cessation of product use, such activity would need to be confirmed with further studies.

Topics: Adult; Aged; Analysis of Variance; Dentifrices; Diphosphates; Drug Combinations; Female; Follow-Up Studies; Humans; Hydrogen Peroxide; Male; Middle Aged; Prospective Studies; Silicon Dioxide; Sodium Bicarbonate; Tooth Bleaching; Tooth Bleaching Agents; Tooth Discoloration; Young Adult

A single-centre, randomized single-blind parallel study was undertaken to compare staining seen with three brushing regimens and to determine subject perception of side effects such as staining and effects on taste.. This 6-week parallel study used 157 volunteers who were randomized into one of three treatment groups: (i) brushing in the morning and evening with a normal dose of a 1% chlorhexidine gel, (ii) brushing with a low dose of chlorhexidine gel in the evening and a whitening dentifrice in the morning, and (iii) brushing with a standard fluoride paste in the morning and evening. Following home usage of their allocated products, the study volunteers returned after 3 and 6 weeks to record the amount of stain present. After the 6-week period, subject perception of taste and stain acceptability was determined using a questionnaire.. After 6 weeks of use of the low-dose chlorhexidine gel and whitening dentifrice, significantly more stain was seen compared with the use of a standard dentifrice (P<0.0001). Similarly, significantly more stain was seen with use of the normal-dose chlorhexidine gel compared with the low-dose gel and whitening dentifrice (P=0.0007). Approximately 30% of individuals on the low-dose chlorhexidine gel regimen found the amount of stain unacceptable and 10% noted an effect on their taste perception.. The use of low dose of chlorhexidine gel at night and a whitening paste in the morning produced a significant amount of stain that 30% of subjects considered unacceptable.

Topics: Adult; Anti-Infective Agents, Local; Chlorhexidine; Complex Mixtures; Dentifrices; Diphosphates; Female; Humans; Male; Polyphosphates; Potassium Compounds; Silicic Acid; Silicon Dioxide; Single-Blind Method; Sodium Fluoride; Tooth Discoloration; Toothbrushing; Toothpastes

The purpose of this ongoing prospective long-term study was to evaluate the clinical performance of Ormocer restorative material in combination with a self-conditioning adhesive. Five operators at five clinics placed 356 restorations (48 class I, 150 class II, 63 class III, 32 class IV, and 63 class V) in 117 patients aged 17 to 65 years. All fillings were placed with cotton roll isolation and clear matrix bands for class III and IV restorations, and metal matrix bands and an incremental placement technique were used for class II restorations. In follow-up examinations after 6 and 12 months, modified Ryge criteria were recorded on all restorations. With 33 randomly selected class I and II restorations, measurements of occlusal wear (via 3D laser scanner) and qualitative and quantitative marginal analysis (via scanning electron microscope) were performed using a replica technique. After placing the fillings, patients reported postoperative hypersensitivity corresponding to B scores in 19 cases and to C scores in four cases. At 12-month recall, 328 restorations were available for evaluation. Losses in the five cavity classes (I, II, III, IV, V) numbered 0, 2, 0, 1, and 6, respectively. The percentages of retained restorations for clinical parameters in four categories (Alpha, Beta, Charlie, Delta) were: 94.7, 5, 0.3, and 0 (marginal integrity), 81.2, 18.8, 0, and 0 (marginal discoloration), 75.2, 24.8, 0, and 0 (anatomic form), and 95, 4.7, 0.3, and 0 (fracture), respectively. Marginal analysis showed 48.7% "continuous margin" initially and 17.7% at 12 months (difference statistically significant, P=0.05). The occlusal wear at 12 months was 10.0 microm (SD 11.6) for premolars and 22.0 microm (SD 24.1) for molars. Over the 12-month observation period, the Ormocer restorative was clinically effective in combination with a self-conditioning adhesive, and concern persists related to the marginal quality and retention of class V restorations.

Topics: Adolescent; Adult; Aged; Ceramics; Composite Resins; Dental Cavity Preparation; Dental Marginal Adaptation; Dental Restoration Failure; Dental Restoration Wear; Dental Restoration, Permanent; Dentin Sensitivity; Diphosphates; Ethanol; Humans; Methacrylates; Middle Aged; Molar; Organically Modified Ceramics; Prospective Studies; Resin Cements; Silanes; Siloxanes; Statistics, Nonparametric; Terpenes; Tooth Discoloration

An 8-week randomized, double-blind, parallel group clinical study was conducted to assess the extrinsic stain prevention efficacy of three commercially available dentifrices: 1) a dentifrice containing 0.243% sodium fluoride with copolymer, tetrasodium pyrophosphate, and sodium tripolyphosphate in a silica base (Product 1); 2) a dentifrice containing 0.243% sodium fluoride, baking soda and peroxide, tetrasodium pyrophosphate, and sodium tripolyphosphate in a silica base (Product 2); and 3) a dentifrice containing 0.243% sodium fluoride in a silica base (Product 3). After the collection of baseline stain scores by a trained examiner and a subsequent oral prophylaxis, 126 volunteers were randomized to one of the three treatment groups (balanced for composite extrinsic stain scores). Throughout the 8-week treatment period, subjects brushed their teeth twice daily with their assigned dentifrice. At baseline, 4-, and 8-week evaluations, extrinsic dental stain was measured on the facial surfaces of the six maxillary anterior teeth and on the facial and lingual surfaces of the six mandibular anterior teeth using the Lobene Index. A total of 120 subjects completed the study. No adverse events were reported, and subjects who discontinued the study did so for reasons unrelated to the dentifrices. At the 4-week evaluation, composite stain scores were statistically significantly lower (P < .05) for both Product 1 (44.9%) and for Product 2 (34.6%) relative to Product 3. At the 8-week evaluation, composite stain scores were statistically significantly lower (P < .05) for both Product 1 (28.4%) and for Product 2 (29.6%) relative to Product 3. The results of this clinical study demonstrate that both dentifrices, one containing 0.234% sodium fluoride with copolymer, tetrasodium pyrophosphate, and sodium tripolyphosphate in a silica base; and one with 0.243% sodium fluoride with copolymer, tetrasodium pyrophosphate, and sodium tripolyphosphate in a silica base are more effective in preventing natural extrinsic stain formation on teeth as compared with a marketed control dentifrice.

Topics: Adult; Analysis of Variance; Complex Mixtures; Dentifrices; Diphosphates; Double-Blind Method; Drug Combinations; Female; Humans; Hydrogen Peroxide; Male; Silicic Acid; Silicon Dioxide; Sodium Bicarbonate; Sodium Fluoride; Tooth Bleaching; Tooth Discoloration; Toothpastes; Treatment Outcome

The objective of this double-blind clinical study was to compare the tooth whitening efficacy (stain removal) of a new commercially available tooth whitening dentifrice (Colgate Total Plus Whitening Toothpaste) containing 0.2% triclosan and 3.0% PVM/MA copolymer in a 0.243% sodium fluoride/high cleaning silica base, with that of two commercially available dentifrices, Crest Multi-Care Advanced Cleaning Toothpaste and Colgate Winterfresh Gel Fluoride Toothpaste. Following a baseline examination to assess extrinsic tooth stain, qualifying adult male and female subjects were randomized into three treatment groups which were balanced for gender, age and level of extrinsic tooth stain. Subjects were asked to brush their teeth twice (morning and evening) for one minute with their assigned dentifrice using a soft-bristled toothbrush. Examinations for extrinsic tooth stain were repeated after six weeks' use of the study dentifrices. One-hundred and twenty-three (123) subjects complied with the protocol and completed the study. At the six-week examination, subjects assigned to the Colgate Total Plus Whitening Toothpaste treatment group exhibited statistically significant reductions in extrinsic tooth stain area and extrinsic tooth stain intensity relative to those subjects assigned to the Crest Multi-Care Advanced Cleaning Toothpaste and the Colgate Winterfresh Gel Fluoride Toothpaste.

Topics: Adolescent; Adult; Aged; Analysis of Variance; Complex Mixtures; Dentifrices; Diphosphates; Double-Blind Method; Female; Humans; Male; Middle Aged; Polystyrenes; Silicic Acid; Silicon Dioxide; Sodium Fluoride; Tooth Discoloration; Toothpastes; Treatment Outcome; Triclosan; Xylitol

A nine-week, double blind clinical trial was conducted to evaluate the effectiveness of a novel tartar control whitening dentifrice with a silica-based abrasive system on induced dental stain. The study model involved three weeks of stain induction followed by six weeks of unsupervised brushing to assess efficacy. To induce stain, 222 healthy adult volunteers received a dental prophylaxis, and then began a limited brushing regimen supplemented by three-times daily rinsing with tea and once daily rinsing with 15 ml of 0.12% chlorhexidine. This regimen was suspended, and 187 subjects with tooth stain were entered into a six-week clinical trial where they were randomized to either a silica-based tartar control whitening dentifrice or a marketed regular dentifrice control, balancing for stain levels and smoking status. At baseline, three and six weeks, stain area and stain intensity were measured on the 8 anterior teeth using the Lobene Index. After six weeks' use, composite Lobene means were 35% lower for the whitening dentifrice compared to the regular control. In addition to the overall reductions, there were statistically significant reductions in stain area (p < 0.015) and stain intensity (p < 0.01) at both three and six weeks. The tartar control whitening dentifrice was effective in removing stain on the gingival margins and elsewhere on the body of the tooth. Safety profiles for the two test dentifrices were generally similar. After three and six weeks' use, the tartar control whitening dentifrice reduced chlorhexidine and tea stain compared to the marketed control.

Topics: Adult; Analysis of Variance; Anti-Infective Agents, Local; Cariostatic Agents; Chlorhexidine; Dental Calculus; Dentifrices; Diphosphates; Double-Blind Method; Female; Follow-Up Studies; Gingiva; Humans; Male; Safety; Silicon Dioxide; Smoking; Sodium Fluoride; Tea; Tooth; Tooth Bleaching; Tooth Discoloration; Toothbrushing

Pellicle rapidly accumulates on tooth surfaces after prophylaxis and may acquire cosmetically unacceptable levels of stain. A three-month clinical trial was conducted to evaluate stain prevention by a new silica-based tartar control whitening dentifrice (Crest Extra Whitening) compared to marketed tartar control baking soda peroxide whitening and regular dentifrice controls. Prior to the trial, a one-month screening exercise was conducted to identify adult subjects who accumulated extrinsic tooth stain after dental prophylaxis. A total of 672 subjects were stratified based on tooth whiteness, gender and tobacco usage, then given a dental prophylaxis and randomized into one of three dentifrice treatment groups. All product use was unsupervised. Change in tooth whiteness (delta L*) was determined by comparing colorimeter measurements collected on the facial surfaces of the four central incisors at months 1 and 3 to baseline. Ninety-six percent of subjects completed the three-month study. At both one and three months, the two whitening dentifrices did not differ from baseline in terms of delta L*. In contrast, the regular control had delta L* values of -0.26 and -0.39 at one and three months, respectively, differing significantly from baseline at both time points. Each of the whitening dentifrices differed statistically from the regular control in stain accumulation (p < or = 0.001) at one and three months, but were not different from each other. In general, all three test dentifrices were well tolerated. These data demonstrate the effectiveness of the new tartar control whitening dentifrice in preventing stain accumulation after dental prophylaxis compared to the marketed regular dentifrice control.

Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Cariostatic Agents; Color; Colorimetry; Dental Calculus; Dental Pellicle; Dental Prophylaxis; Dentifrices; Diphosphates; Double-Blind Method; Female; Follow-Up Studies; Humans; Incisor; Male; Middle Aged; Oxidants; Peroxides; Safety; Silicon Dioxide; Smoking; Sodium Bicarbonate; Sodium Fluoride; Tooth; Tooth Bleaching; Tooth Discoloration

Changing and whitening tooth color in people with long-standing tooth stain without excessive hard tissue abrasion may represent one of the more difficult challenges for whitening dentifrices. An eight-week clinical trial was conducted to evaluate change in tooth color by a silica-based, enamel-safe tartar control whitening dentifrice compared to a marketed baking soda dentifrice control. First, a screening exercise was conducted to identify individuals with long-standing extrinsic dental stain. This exercise targeted adults who reported "stained teeth" and coffee/tea drinking or smoking, but who had no recent history of dental prophylaxis. Targeted subjects were examined for stain (Lobene Index) and tooth shade/color (Vita). A total of 291 adults having extrinsic stain and discolored teeth were enrolled in the study. Subjects were randomized to one of the two treatment groups, and all dentifrice use was unsupervised. Tooth color was measured at 4 and 8 weeks from shade values collected from the 8 incisors, and averages were determined from a linear ordering of the shade guide. A total of 278 evaluable subjects completed the 8-week study. Overall, the tartar control whitening dentifrice group experienced an improvement in color, differing statistically from baseline (p < 0.001) and from the marketed control (p < 0.05). Safety profiles for the two dentifrices were generally similar. Among patients with long-standing extrinsic stain, use of the tartar control whitening dentifrice resulted in superior overall tooth shade and reduced maximum or worst color compared to the marketed baking soda dentifrice control.

Topics: Adult; Aged; Cariostatic Agents; Coffee; Color; Dental Calculus; Dentifrices; Diphosphates; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Safety; Silicon Dioxide; Smoking; Sodium Bicarbonate; Sodium Fluoride; Statistics, Nonparametric; Tea; Tooth; Tooth Bleaching; Tooth Discoloration

Regular use of an effective oral rinse (0.12% chlorhexidine [CHX]) may be accompanied by tooth staining and slightly increased calculus formation. Since dentifrices containing soluble pyrophosphates are known to significantly reduce calculus formation, this study was designed to investigate whether CHX-induced staining and increased calculus may be reduced by the use of such dentifrices. The study compared stain and calculus formation in 163 subjects using a CHX oral rinse (Peridex, Procter & Gamble) according to label directions and either a pyrophosphate-containing anticalculus toothpaste (Tartar-Control Crest, 3.3% pyrophosphate) or an otherwise similar toothpaste without pyrophosphate (Regular Crest). Subjects were instructed to brush and floss ad lib and were examined after three and six months. Whole-mouth calculus occurrence was significantly reduced in the anticalculus toothpaste group at three and six months. Also, staining on the cosmetically important facial-anterior surfaces was significantly reduced at the 3-month examination. After six months the difference in facial anterior staining was still directionally favorable to the anticalculus toothpaste group but no longer statistically significant. These results indicate that routine brushing with an anticalculus toothpaste such as Tartar-Control Crest significantly reduces both facial-anterior staining and calculus occurrence in subjects using a CHX oral rinse. Whether more frequent or more thorough brushing would lead to still greater reductions remains to be investigated.

Topics: Adolescent; Adult; Analysis of Variance; Chlorhexidine; Dental Calculus; Dental Plaque Index; Dentifrices; Diphosphates; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Mouthwashes; Silicic Acid; Silicon Dioxide; Sodium Fluoride; Tooth Discoloration; Toothbrushing; Toothpastes

Significant differences in stain removal have been demonstrated in a laboratory study comparing two tartar control dentifrices: Platinum, containing 1.3% soluble pyrophosphate and 1.5% of a copolymer, and Crest Tartar Control, containing 5% soluble pyrophosphate. The purpose of this clinical study was to evaluate the same tartar control dentifrices, and a low abrasive dentifrice for their ability to reduce Peridex-induced stain. Eighty-five subjects were given Peridex (0.12% chlorhexidine digluconate) and a low abrasive dentifrice for 4 weeks. The 76 subjects with sufficient stain were stratified using the Lobene index on buccal and lingual surfaces of anterior teeth, and randomly assigned one of the three dentifrices for 8 weeks. At the end of the study, total stain evaluations were significantly lower in the Platinum dentifrice group (mean 0.84) compared to both Crest Tartar Control dentifrice (1.08) and the low abrasive dentifrice (1.09) at p<0.05 by ANOVA. In this 8-week clinical study, Platinum dentifrice was significantly more effective than Crest Tartar Control dentifrice or a low abrasive dentifrice in reducing Peridex-induced stain, and this finding correlates well with laboratory data on removal of tea and coffee stain.

Topics: Adult; Analysis of Variance; Chlorhexidine; Dentifrices; Diphosphates; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Polyethylenes; Sodium Fluoride; Tooth Discoloration

To evaluate the stain removal efficacy of two different toothbrush designs using a laboratory stained pellicle test with seven different dentifrices.. The toothbrushes were a prototype powered toothbrush (Crest SpinBrush Pro Whitening) and an ADA reference manual toothbrush, as a control. The dentifrices used in the study were: Crest Dual Action Whitening (Cool Mint), Crest Extra Whitening with Tartar Control (Clean Mint), Crest MultiCare Whitening (Fresh Mint), Colgate Total, Colgate Total Plus Whitening, Arm & Hammer Advance White with Tartar Control and Rembrandt Plus with Active Dental Peroxide. This was a randomized, parallel group study that examined stain removal with a novel toothbrushing configuration adapted for powered and manual toothbrushes. Stain was scored before and after brushing for two consecutive, 1-minute periods using digital image analysis. The mean change in L* was statistically compared between toothbrushes with ANCOVA. Labial enamel specimens were obtained from bovine permanent incisors and these specimens were subjected to a laboratory staining process until the L* values for the samples were in the range of 35-45. Digital images for CIE L*a*b* analysis were captured using a high-resolution digital camera under standard polarized lighting conditions. Based on the L* values, the enamel specimens were divided into 14 groups of nine specimens each.. Baseline L* values ranged from 40.62 to 41.38 for the 14 toothbrush/dentifrice combinations. The change in L* (post-brushing minus baseline), denoted as deltaL*, was calculated for each specimen and the resulting data were subjected to a two-way ANCOVA. Toothbrush type and dentifrice type were the two terms in the model, and baseline L* was the covariate. Pairwise tests were performed on the adjusted means in order to compare the stain removal efficacy of the two toothbrushes for each of the seven dentifrices evaluated. The powered toothbrush resulted in statistically significantly greater deltaL* values (all P < or = 0.006) than the manual toothbrush for every dentifrice tested. The deltaL* values for dentifrices used with the powered toothbrush were from 66.0-164.2% higher than for the same dentifrice used with the manual toothbrush.

Topics: Analysis of Variance; Animals; Cattle; Color; Complex Mixtures; Dental Enamel; Dentifrices; Diphosphates; Electric Power Supplies; Equipment Design; Fluorides; Image Processing, Computer-Assisted; Matched-Pair Analysis; Phosphates; Polystyrenes; Random Allocation; Silicic Acid; Silicon Dioxide; Sodium Fluoride; Tooth Discoloration; Toothbrushing; Toothpastes; Triclosan; Xylitol

Laboratory studies were developed to permit the evaluation of chemical actions of toothpaste components in the non-abrasive prevention and removal of tea stains. Powdered hydroxyapatites were used as substrates for adsorption of tea chromogens. Pre-treatment with a sodium hexametaphosphate dentifrice (Crest Dual Action Whitening) reduced tea adsorption to powdered apatite, while post-treatments of pre-stained powder resulted in desorption of tea components. These results exemplified the chemical actions of condensed calcium phosphate surface active builders toward dental stain removal and prevention. A cycling synamel chip model permitted the study of stain prevention, including salivary pellicle formation and chlorhexidine enhancement of dental staining by tea chromogens. Staining was evaluated by image analysis of color development. Under these conditions, condensed phosphate dentifrices were observed to produce superior prevention of stain accumulations, with Crest Dual Action Whitening dentifrice providing stain prevention superior to a variety of commercial dentifrices, including Colgate Total, Aquafresh Whitening, Colgate Tartar Control Whitening, Mentadent Baking Soda and Peroxide Whitening, Close-Up Whitening, Crest Tartar Control and Crest Regular Cavity Protection.

Topics: Adsorption; Carbamide Peroxide; Chlorhexidine; Complex Mixtures; Dental Pellicle; Dentifrices; Diphosphates; Drug Combinations; Durapatite; Fluorides; Hydrogen Peroxide; Peroxides; Phosphates; Polyphosphates; Silicic Acid; Silicon Dioxide; Sodium Bicarbonate; Sodium Fluoride; Tea; Tooth Bleaching; Tooth Discoloration; Toothpastes; Triclosan; Urea

A series of pH cycling "profile" laboratory studies was conducted to confirm the anticaries potential of an enhanced cleaning and whitening dentifrice based on a novel abrasive polishing silica and pyrophosphate tartar control source, with sodium fluoride as the anticaries ingredient. Under pH cycling remineralization conditions, the whitening dentifrice produced lesion fluoridation comparable to a conventional tartar control dentifrice containing combinations of pyrophosphate anion and a NaF fluoride ion source. Under pH cycling lesion progression conditions, the whitening dentifrice produced enamel protection against caries development, comparable to control dentifrices containing NaF alone or in combination with tartar control pyrophosphate anion. These results are consistent with clinical data supporting the effectiveness of NaF dentifrices combined with anionic tartar control inhibitors such as pyrophosphate. These results support the anticaries effectiveness of the enhanced cleaning and whitening dentifrice based upon "Stain-Specific Soft Silica."

Topics: Analysis of Variance; Cariostatic Agents; Dental Calculus; Dental Caries; Dental Enamel; Dentifrices; Diphosphates; Disease Progression; Hardness; Humans; Hydrogen-Ion Concentration; Silicon Dioxide; Sodium Fluoride; Tooth Bleaching; Tooth Demineralization; Tooth Discoloration; Tooth Remineralization

Crystal growth inhibition and plaque biofilm calcification laboratory studies were conducted to confirm the anticalculus potential of an enhanced cleaning and whitening dentifrice, based upon a novel enamel-safe, abrasive-polishing silica and pyrophosphate tartar control source with sodium fluoride as the anticaries ingredient. Calcium hydroxyapatite crystal growth following direct supernate treatments was significantly inhibited by the advanced whitening dentifrice. Similarly, plaque biofilm calcification was significantly inhibited by supernate treatments of the advanced whitening dentifrice. In both protocols, the advanced whitening dentifrice produced activity similar to formulations clinically proven for antitartar activity. These results provide support for the antitartar clinical activity of this new dentifrice.

Topics: Biofilms; Calcium; Cariostatic Agents; Chemistry, Pharmaceutical; Crystallization; Dental Calculus; Dental Enamel; Dental Plaque; Dentifrices; Diphosphates; Durapatite; Humans; Hydrogen-Ion Concentration; Saliva; Saliva, Artificial; Silicon Dioxide; Sodium Fluoride; Sucrose; Tooth Bleaching; Tooth Discoloration

These laboratory studies examined the stain removal efficacy and hard tissue abrasivity of a new dentifrice formulation--Crest Extra Whitening--based on the incorporation of elevated concentrations of a proprietary silica. Cleaning power assessments were made using a modification of the laboratory test method developed by Stookey and associates at Indiana University Oral Health Research Institute. Abrasion assessments were made using Radioactive Enamel and Radioactive Dentin Abrasivity (REA and RDA) measures. Results show that Crest Extra Whitening dentifrice produced statistically significantly improved stain removal when compared to a number of conventional dentifrices, including Crest Cavity Protection and Crest Tartar Protection, and a number of recently marketed cleaning and whitening dentifrices. Laboratory studies further demonstrated that the Crest Extra Whitening dentifrice produces dentin and enamel abrasivity similar to conventional silica dentifrices.

Topics: Aluminum Oxide; Animals; Bicarbonates; Cariostatic Agents; Cattle; Chemistry, Pharmaceutical; Color; Dental Calculus; Dental Deposits; Dental Enamel; Dentifrices; Dentin; Diphosphates; Phosphorus Radioisotopes; Radiopharmaceuticals; Silicon Dioxide; Sodium Fluoride; Surface Properties; Technology, Pharmaceutical; Tooth Bleaching; Tooth Discoloration; Toothbrushing