pyrophosphate and Tibial-Fractures

Topics: Cumulative Trauma Disorders; Diphosphates; Disease Outbreaks; Female; Femoral Fractures; Humans; Military Medicine; Radiography; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate; Tibial Fractures; United States

Five elderly patients with chronic pyrophosphate arthropathy developed stress fractures of the tibia. All patients had deformed, painful knees with the result that their increasing symptoms were not readily attributed to a stress fracture. Such a possibility should be considered in patients with chronic pyrophosphate arthropathy since early recognition makes management of the stress fracture easier.

Topics: Aged; Arthritis; Calcium Pyrophosphate; Cartilage, Articular; Diphosphates; Female; Fractures, Spontaneous; Humans; Knee Joint; Radiography; Tibia; Tibial Fractures

In 20 cases routine static bone scans were no value in the detection of delayed fracture healing. Using the 7.5-15 min net uptake of technetium labelled phosphate, disturbed fracture healing was detected in a series, of 37 cases. Normally healing fractures had an increase of 3 per cent per month and delayed unions less than half that amount. Non-unions had no net uptake.

Topics: Bone Transplantation; Diphosphates; Diphosphonates; Fracture Fixation; Fractures, Bone; Fractures, Ununited; Humans; Male; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Technetium Tc 99m Pyrophosphate; Tibial Fractures; Time Factors; Wound Healing

Topics: Animals; Bone Regeneration; Bone Transplantation; Diphosphates; Dogs; Female; Femoral Fractures; Male; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate; Tibial Fractures

The clinical, laboratory, and radiologic picture of a unique patient with symmetrical fractures of the anterior tibial midshafts, dorsal ulnar cortices, and lateral metatarsals is presented. The findings are not compatible with a diagnosis of osteogenesis imperfecta or osteomalacia despite osseous fragility. The elevated serum pyrophosphate and low urine phosphate content suggest that abnormalities in phosphate metabolism may have contributed to the formation of bone which is biochemically and structurally deficient.

Topics: Child; Diphosphates; Fractures, Bone; Humans; Male; Metatarsus; Radiography; Tibial Fractures; Ulna Fractures

Activity levels of 99TC-labeled compounds, 18F, and 85Sr were obtained at 1, 3, and 5 hr. postinjection in normal and healing fractured bone and in soft-tissue rat specimens. Serial diagnostic bone images and blood and urine kinetics were obtained in patients with each of the TC-labeled compounds. Computer-processed images were used to evaluate in vivo kinetics. 99mTC pyrophosphate provides the best overall characteristics for bone imaging. Improved quality and bioassay procedures are required, however, before any one agent can be designated the radiopharmaceutical of choice for diagnostic bone imaging.

Topics: Animals; Diphosphates; Disease Models, Animal; Fluorine; Fractures, Bone; Humans; Isotope Labeling; Kinetics; Phosphates; Radioisotopes; Radionuclide Imaging; Rats; Strontium Radioisotopes; Technetium; Tibial Fractures; Wound Healing

The concentration of 99mTc-pyrophosphate was determined in the lower extremities of rabbits (normal, abacterial and bacterial affected soft tissues), in osteoarthritis of the hip joint (capsule and muscle) as well as in knee joint effusions. Compared with the 85Sr-concentration, reflecting the calcification capacity, concentrations of 99mTc-pyrophosphate in soft tissues were found to be lower 2 hours p.i., but were up to elevenfold higher 24 hours p.i. These findings should be due to a fixation of 99mTc-pyrophosphate in collagen containing tissues as in the soft tissue tumors (myosarcoma, synvialioma, breast cancer) presented. A mechanism of delayed equilibration could explain augmented uptake in lymph-edema, ascites and effusions in florid osteoarthritis of the knee joint. The possible dependence of 99mTc-pyrophosphate concentration in bone and soft tissue on collagenous contents is discussed.

Topics: Animals; Ascites; Bone and Bones; Breast Neoplasms; Diphosphates; Disease Models, Animal; Extremities; Freund's Adjuvant; Hip; Humans; Joint Diseases; Joint Prosthesis; Joints; Knee; Osteoarthritis; Phosphates; Rabbits; Rhabdomyosarcoma; Sarcoma, Synovial; Strontium; Strontium Radioisotopes; Technetium; Tibial Fractures; Time Factors; Tin