pyrophosphate and Soft-Tissue-Neoplasms

Reported a case of liposarcoma of the left thigh with accumulation of 99mTc-PYP and Ga-citrate, which was remarkably decreased by transarterial embolization. To our knowledge, this is the first case that concentration of Tc-PYP and Ga-citrate was the useful indicator of the effect of transarterial embolization.

Topics: Aged; Bone and Bones; Citrates; Diphosphates; Embolization, Therapeutic; Female; Gallium Radioisotopes; Humans; Liposarcoma; Radionuclide Imaging; Soft Tissue Neoplasms; Technetium; Technetium Tc 99m Pyrophosphate

The paper is concerned with the results of radionuclide investigation of 51 patients with different tumors located beyond the osseous tissue. In spite of the fact that 99mTc-phosphates were well known as agents for radionuclide diagnosis of bone tumors, they can be employed for obtaining certain diagnostic information concerning topical diagnosis and the determination of a degree of the distribution of processes of nonskeletogenous nature. Of 51 patients with soft tissue pathology clear visualization of lesion foci was obtained in 34 patients (66.7%). Positive results of radionuclide diagnosis with 99mTc-pyrophosphate were noted in scintigraphy of patients with breast, ovarian, soft tissue and maxillofacial tumors. Besides, clear visualization of lesion foci was achieved in 6 of 11 patients with benign diseases: postoperative scars, inflammatory infiltrates, synovioma. The results obtained indicated the absence of necessary specificity of 99mTc-phosphates to osseous tissue.

Topics: Breast Neoplasms; Diphosphates; Facial Neoplasms; Female; Genital Neoplasms, Female; Humans; Radionuclide Imaging; Soft Tissue Neoplasms; Spinal Cord Neoplasms; Technetium; Technetium Tc 99m Pyrophosphate

Topics: Adolescent; Bone Neoplasms; Child; Child, Preschool; Diagnosis, Differential; Diphosphates; Evaluation Studies as Topic; Humans; Infant; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Soft Tissue Neoplasms; Technetium; Technetium Tc 99m Pyrophosphate

Topics: Bone and Bones; Bone Neoplasms; Diphosphates; Head and Neck Neoplasms; Humans; Neoplasm Staging; Radionuclide Imaging; Scintillation Counting; Soft Tissue Neoplasms; Technetium; Technetium Tc 99m Pyrophosphate

Radionuclide imaging with technetium-99m phosphate compounds was performed in 18 patients with deep-seated soft-tissue masses. The histologically established diagnosis was intra- or intermuscular lipoma in 13 patients and liposarcoma in five. Radionuclide scans demonstrated disparate scintigraphic characteristics in these two often clinically similar lesions. Soft-tissue radionuclide accumulation occurred in two lipomas and corresponded to radiographically evident calcification. All liposarcomas were uncalcified and demonstrated intense radionuclide activity. This activity may be related to the angiographic and histologic hypervascularity of liposarcomas, which is also demonstrable on computed tomography as contrast enhancement; hence, these modalities offer the same nonspecific diagnostic information. It is concluded, however, that plain radiography and radionuclide scaning should suffice to establish the diagnosis of lipoma.

Topics: Adult; Aged; Diphosphates; Diphosphonates; Extremities; Female; Humans; Lipoma; Liposarcoma; Male; Middle Aged; Radionuclide Imaging; Soft Tissue Neoplasms; Technetium