pyrophosphate and Pseudarthrosis

The effect of electric stimulation with direct constant current in induced pseudarthrosis was investigated in the radius of adult dogs. Two surgical techniques for inducing nonunion in the lower third of the radius of adult dogs are also described. Results were evaluated by clinical, radiologic, and histologic examinations and by 99mTc scintillation. A total of 57 animals (41 electrically stimulated and 16 control animals) was used. Statistically significant data show activation of endochrondral ossification and bone union by electric stimulation.

Topics: Animals; Diphosphates; Dogs; Electric Stimulation Therapy; Fractures, Ununited; Microscopy, Electron; Osteogenesis; Pseudarthrosis; Radius Fractures; Technetium; Technetium Tc 99m Pyrophosphate; Wound Healing

Topics: Bone Regeneration; Capillaries; Diphosphates; Female; Humans; Orthopedic Fixation Devices; Pentetic Acid; Pseudarthrosis; Radionuclide Imaging; Technetium; Technetium Tc 99m Pentetate; Technetium Tc 99m Pyrophosphate; Tibia; Time Factors

Four cases of ankylosing spondylitis are presented in which radionuclide bone studies indicated focal abnormalities of the spine. In three patients, the area of abnormal nuclide uptake corresponded to a site of pseudarthrosis, and in the fourth an acute fracture was present. As such focal lesions on bone scans are unusual in cases of chronic ankylosing spondylitis in which a complication is not apparent, their presence can be a useful finding.

Topics: Aged; Diphosphates; Diphosphonates; Fractures, Bone; Humans; Male; Middle Aged; Pseudarthrosis; Radiography; Radionuclide Imaging; Spinal Injuries; Spine; Spondylitis, Ankylosing; Technetium; Technetium Compounds; Technetium Tc 99m Pyrophosphate

Topics: Bone Matrix; Calcification, Physiologic; Calcium; Citrates; Collagen; Diphosphates; Hexosamines; Histocytochemistry; Humans; Hydroxyproline; Phosphates; Phosphoric Monoester Hydrolases; Pseudarthrosis; Pyrophosphatases