pyrophosphate has been researched along with Proteinuria* in 2 studies
1 review(s) available for pyrophosphate and Proteinuria
| Article | Year |
|---|---|
Phosphate metabolism and renal calcium stone disease.
The purpose of the present investigation was to study various aspects of phosphate metabolism in renal calcium stone patients with special reference to the renal handling of phosphate and its relationship to other renal tubular functions and calcium metabolism. Serum phosphate and the capacity for renal tubular reabsorption of phosphate were lower in stone patients than in controls and decreased with advancing age. Reduced tubular phosphate reabsorption was particularly evident in stone patients with other tubular dysfunctions. Absorptive hypercalciuria was common, but unrelated to the renal tubular reabsorption of phosphate. Parathyroid hyperfunction was not observed in stone formers. Various loads of dietary phosphate resulted in similar renal adaptive responses in controls and stone formers. Orthophosphate supplementation had metabolic consequences with potentially beneficial effects for stone prevention (increased urinary pyrophosphate, decreased urinary calcium). The altered renal handling of phosphate in calcium stone formers may reflect a primary (independent of parathyroid hormone) renal tubular dysfunction in phosphate reabsorption. Topics: Absorption; Acid-Base Equilibrium; Calcium; Diphosphates; Humans; Hypoparathyroidism; Kidney; Kidney Calculi; Kidney Tubules; Phosphates; Proteinuria; Sodium | 1981 |
1 other study(ies) available for pyrophosphate and Proteinuria
| Article | Year |
|---|---|
Aggregation of calcium oxalate crystals: effect of urine and various inhibitors.
The influence of various factors on aggregation of calcium oxalate crystals in vitro was determined. Aggregation was assessed by filtering the crystal suspension and measuring the flow rate through a filter. 10% urine completely inhibited aggregation. Orthophosphate and magnesium at concentrations occuring in urine had no effect. Citrate had no effect at 10(-4) M ,but did inhibit at 10(-3) M. The latter effect is probably due to calcium binding. Pyrophosphate and disodium dichioromethylene diphosphonate (C12MDP) inhibited strongly at 10(-4) M, disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) at 10(-5) M, whereas pentanemonophosphonate had no effect. Uromucoid also did not show any inhibitory activity. Studies by means of heat inactivation, ultrafiltration and fractionation on DEAE-cellulose and gel-filtration indicated that the inhibitory activity was heterogenous and that the major part was larger than 10 000 daltons. Topics: Calcium; Crystallization; Diphosphates; Diphosphonates; Humans; Hydrogen-Ion Concentration; Magnesium; Male; Molecular Weight; Organophosphonates; Oxalates; Phosphates; Proteinuria | 1977 |