pyrophosphate and Pericarditis

Topics: Animals; Diphosphates; Dogs; Gluconates; Heart; Organotechnetium Compounds; Pericarditis; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate

Topics: Adult; Aged; Diphosphates; Female; Gluconates; Heart; Humans; Male; Middle Aged; Organotechnetium Compounds; Pericarditis; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate

A focal or diffuse pattern of Tc-99m pyrophosphate (Tc-99m PPi) myocardial uptake may occur in patients with acute myocardial necrosis from various causes. A recent study has shown intense Tc-99m PPi myocardial uptake in experimental viral perimyocarditis in mice. This report describes a patient with perimyocarditis, with intense, persistent, and generalized myocardial uptake of Tc99m PPi.

Topics: Diphosphates; Heart; Heart Failure; Heart Ventricles; Humans; Male; Middle Aged; Myocarditis; Myocardium; Pericarditis; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate

In the present paper the possibilities of scintigraphic diagnosis of experimental pericarditis are discussed. Pericarditis was induced by either talc or formaldehyde intrapericardially. In all animals the administration of talc as well as formaldehyde produced inflammatory changes which were more serious after formaldehyde. The scan of the talc pericarditis was carried out on the 7th day after operation and of the formaldehyde pericarditis on the 3rd, 7th or 14th days. No positive scintigraphic finding was made in any of the experimental animals, apart from a massive incorporation in the operation scars. The counting of radioactive impulses after the exstirpation of the tissue samples confirmed the scintigraphic findings. Statistical evaluation did not reveal any essential difference between the accumulation of the radiopharmaceutical into the pericarditis as well as into the pericardial bag in comparison with the control animals. Although our model does not exactly reflect the situation of patients suffering from pericarditis it may be assumed that pyrophosphate scintigraphy is not suitable for the diagnosis of acute pericarditis in clinical practice.

Topics: Animals; Diphosphates; Dogs; Formaldehyde; Pericarditis; Radionuclide Imaging; Talc; Technetium; Technetium Tc 99m Pyrophosphate

Fifteen patients with clinical and electrocardiographic features of acute pericarditis underwent myocardial scintigraphy using 99mTc-pyrophosphate. All had normal images. In 5 additional patients with acute pericarditis and evidence of ischemic heart disease, 99mTc-pyrophosphate images showed focal abnormalities in 2 patients and equivocal findings in 2. Serial myocardial radionuclide images were obtained 2 to 18 days after induction of pericarditis in 8 dogs; all images were normal. No stainable tissue calcium was demonstrated histochemically in the pericardium or myocardium of these dogs. Our results suggest that 99mTc-PYP myocardial radionuclide images are normal in acute pericarditis in the absence of ischemic heart disease.

Topics: Acute Disease; Animals; Diphosphates; Dogs; Heart; Humans; Myocardium; Pericarditis; Radionuclide Imaging; Technetium

Topics: Cholesterol; Diphosphates; Humans; Pericardial Effusion; Pericarditis; Radionuclide Imaging; Technetium

Technetium-99m-stannous pyrophosphate (99mTc-PYP) accumulates in acutely infarcted myocardium and can be detected by scintiscanning. The clinical value of 99mTc-PYP scintiscanning was studied in 83 patients 6 hours to 21 days after the onset of acute chest pain. In 12 patients with normal electrocardiograms and serum enzyme values no uptake of 99mTc-PYP was detected on the scintigrams. Of 44 patients with electrocardiographic or enzyme evidence, or both, of acute myocardial infarction the scintigrams were positive in 31, "questionable" in 2 and negative in 11; no positive scan was obtained within 12 hours of the onset of pain, and the scans generally remained positive for up to 5 days. In 24 patients with evidence of prolonged myocardial ischemia the scans were positive in 2, questionable in 4 and negative in 18. The scans were negative in each of three patients with acute or constrictive pericarditis. Localization by electrocardiography and scintiscanning correlated nearly perfectly for transmural infarcts but subendocardial infarcts could not always be localized precisely by scintiscanning. The infarct area (total area of 99mTc-PYP uptake) correlated well with the peak serum value of creatine phosphokinase.

Topics: Angina Pectoris; Diphosphates; Humans; Myocardial Infarction; Pericarditis; Radionuclide Imaging; Technetium