pyrophosphate and Osteolysis

Control of Paget's disease of bone has been possible through treatment with agents that decrease bone resorption; calcitonins, diphosphonates, and mithramycin. The pagetic lesion is not, however, cured. Etidronate disodium is one of the diphosphonates. The clinical improvement attained with this drug has to be set against adverse effects, of which pain is probably the most bothersome in practice. Clinical remission can last as long as 2 years after treatment is stopped.

Topics: Bone Resorption; Calcitonin; Clinical Trials as Topic; Diphosphates; Drug Evaluation; Etidronic Acid; Fractures, Bone; Humans; Osteitis Deformans; Osteolysis

Control of Paget's disease of bone has been possible through treatment with agents that decrease bone resorption; calcitonins, diphosphonates, and mithramycin. The pagetic lesion is not, however, cured. Etidronate disodium is one of the diphosphonates. The clinical improvement attained with this drug has to be set against adverse effects, of which pain is probably the most bothersome in practice. Clinical remission can last as long as 2 years after treatment is stopped.

Topics: Bone Resorption; Calcitonin; Clinical Trials as Topic; Diphosphates; Drug Evaluation; Etidronic Acid; Fractures, Bone; Humans; Osteitis Deformans; Osteolysis

Topics: Adolescent; Adult; Aged; Bone Neoplasms; Diphosphates; Female; Humans; Male; Middle Aged; Osteolysis; Radiography; Radionuclide Imaging; Ribs; Strontium Radioisotopes; Technetium; Technetium Tc 99m Pyrophosphate; Time Factors

Scintigraphy is a non-invasive technically simple tool for diagnostic in the head and neck. Using nuclides with a short life time the irradiation of the skeleton is less than 1 rd. Scintigraphy in addition to X-ray examination is useful in diagnosis and surveillance of different osteoplastic tumors (like osteoma, osteoplastoma, cementoma, meningioma) and in systemic diseases of the bones (fibrotic dysplasia, Morbus Paget). Concerning inflammatory diseases osteomyelitis is the main indication for scintigraphy, but it is as well usefull in the diagnosis of complications of inflammatory diseases of the sinuses, like mucocelia or non resorbed antibiotics which provoked an inflammatory reaction of the mucosa. There is no indication for scintigraphy regarding its low specificity in common acute or chronic sinusitis.

Topics: Adult; Aged; Bone Neoplasms; Diagnosis, Differential; Diphosphates; Diphosphonates; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Osteolysis; Osteoma; Osteomyelitis; Radionuclide Imaging; Sinusitis; Technetium; Technetium Tc 99m Pyrophosphate; Tomography, X-Ray

Spontaneous haemarthrosis may occur during the evolution of articular chondrocalcinosis. It occurs mainly in older women and involves the knee in particular. The disorder may recur in the same or in different joints. A study of 11 case histories and counts of red blood corpuscles in samples of synovial fluid confirm that bleeding occurs more readily in chondrocalcinosis than in arthrosis alone. The proposed mechanism of haemarthrosis is only a hypothesis, but it is possible to imagine the onset of microcrystalline flow in a joint that is senile and affected by arthrosis. It is suspected that repeated haemarthrosis favours an oseolytic evolution in certain cases of chondrocalcinosis.

Topics: Aged; Calcium Phosphates; Chondrocalcinosis; Crystallization; Diphosphates; Female; Hemarthrosis; Humans; Inclusion Bodies; Knee Joint; Leg Injuries; Male; Middle Aged; Osteoarthritis; Osteochondritis; Osteolysis; Synovial Fluid

Topics: Arthritis; Bone Diseases; Bone Neoplasms; Diagnosis, Differential; Diphosphates; Hodgkin Disease; Humans; Multiple Myeloma; Neoplasm Metastasis; Osteitis Deformans; Osteoarthritis; Osteolysis; Osteomalacia; Osteoporosis; Radionuclide Imaging; Reflex Sympathetic Dystrophy; Rheumatic Diseases; Technetium; Tin