pyrophosphate and Osteitis-Deformans

Paget's disease of bone affects 10% of those surviving to the eighth decade of life. Relatively easy to diagnose, treatment decisions are more complex. Surgery and immobilization present unique challenges often requiring prophylaxis to prevent activation/exacerbation of the disease.

Topics: Aged; Aged, 80 and over; Calcitonin; Diphosphates; Female; Gout; Humans; Male; Osteitis Deformans; Pain

Control of Paget's disease of bone has been possible through treatment with agents that decrease bone resorption; calcitonins, diphosphonates, and mithramycin. The pagetic lesion is not, however, cured. Etidronate disodium is one of the diphosphonates. The clinical improvement attained with this drug has to be set against adverse effects, of which pain is probably the most bothersome in practice. Clinical remission can last as long as 2 years after treatment is stopped.

Topics: Bone Resorption; Calcitonin; Clinical Trials as Topic; Diphosphates; Drug Evaluation; Etidronic Acid; Fractures, Bone; Humans; Osteitis Deformans; Osteolysis

Topics: Animals; Bone and Bones; Calcification, Physiologic; Calcium Phosphates; Chemical Phenomena; Chemistry; Diphosphates; Diphosphonates; Etidronic Acid; Kinetics; Osteitis Deformans; Rats

Topics: Bone Resorption; Calcification, Physiologic; Calcinosis; Calcium; Calcium Phosphates; Chemical Precipitation; Dental Calculus; Dihydroxycholecalciferols; Diphosphates; Diphosphonates; Humans; Osteitis Deformans; Osteoporosis; Phosphates; Phosphoric Monoester Hydrolases; Radionuclide Imaging; Structure-Activity Relationship

Topics: Androgens; Bone Diseases; Diphosphates; Estrogens; Fluorides; Heparin; Humans; Hyperparathyroidism; Metabolic Diseases; Organophosphonates; Osteitis Deformans; Osteomalacia; Osteoporosis; Parathyroid Hormone; Phosphates; Plicamycin

Control of Paget's disease of bone has been possible through treatment with agents that decrease bone resorption; calcitonins, diphosphonates, and mithramycin. The pagetic lesion is not, however, cured. Etidronate disodium is one of the diphosphonates. The clinical improvement attained with this drug has to be set against adverse effects, of which pain is probably the most bothersome in practice. Clinical remission can last as long as 2 years after treatment is stopped.

Topics: Bone Resorption; Calcitonin; Clinical Trials as Topic; Diphosphates; Drug Evaluation; Etidronic Acid; Fractures, Bone; Humans; Osteitis Deformans; Osteolysis

The authors have performed radioisotope examinations in 271 patients with various non-neoplastic bone diseases. According to their opinion, early diagnosis and follow-up of therapeutic results are the main characteristics which allow radioisotopes to play an important and irreplaceable role. They particularly emphasize the usefulness of radioisotope methods in femoral aseptic necrosis and Paget's disease.

Topics: Adolescent; Bone Diseases; Diphosphates; Epiphyses, Slipped; Female; Femur Head Necrosis; Follow-Up Studies; Hip Prosthesis; Humans; Inflammation; Osteitis Deformans; Postoperative Complications; Radionuclide Imaging; Technetium

Marrow scintigraphy using 99mTc colloids was performed in 20 patients with Paget's disease of bone and compared with skeletal scanning in each of them. As long as the regions explored were haematopoietically active, despite the advanced age of the patients, there was decreased marrow uptake in regions of increased uptake on the skeletal scan. Whilst increased uptake of pyrophosphate reflects bone hyperosteogenesis, decreased uptake of colloids reflects marrow fibrosis, and early histological sign of the disease. This scanning technique could be a new criterion in the surveillance of the therapeutic effectiveness of calcitonins or of diphosphonates.

Topics: Aged; Bone and Bones; Bone Marrow; Colloids; Diphosphates; Female; Humans; Male; Middle Aged; Osteitis Deformans; Radionuclide Imaging; Technetium

This communication describes a series of clinical and animal in vivo and in vitro investigations designed to elucidate the mechanism of 99mTc-Sn-phosphate complex concentration in metabolic bone disease. Rachitic and lathyritic animals were used as experimental models. Based on these studies it is concluded that 99mTc alters the pharmacology of the phosphate complexes, in particular pyrophosphate, which was the test agent most extensively employed, so that the usual affinity for mineral is for the greater part replaced by organic matrix binding. There is also evidence to suggest the immature collagen moiety of the organic matrix is the prime target of 99mTc-Sn-phosphate complex binding. Specifically, the aldehyde groups of the collagen molecule are suspected as being the major site of interaction.

Topics: Aminopropionitrile; Animals; Bone and Bones; Chronic Kidney Disease-Mineral and Bone Disorder; Diphosphates; Humans; Hydroxyproline; Hyperparathyroidism; In Vitro Techniques; Lathyrism; Organophosphorus Compounds; Osteitis Deformans; Osteomalacia; Radionuclide Imaging; Rats; Renal Dialysis; Rickets; Technetium

A study was undertaken to investigate the behavior of 99mTc-Sn-pyrophosphate complex in metabolic bone disease. Of clinical importance was the generalized increased periarticular bone accumulation of the radiopharmaceutical in osteomalacia and in combined osteomalacia and osteitis fibrosa as found in patients with chronic renal failure. The pattern in primary hyperparathyroidism was variable. There was no correlation between the initial rates of accumulation of the radiophosphate complex or its bone to soft-tissue uptake ratio at 5 hr when compared with the degree of osteomalacia and osteitis fibrosa. It is postulated that the 99mTc-Sn-pyrophosphate complex has greater affinity for immature collagen than the crystal surface.

Topics: Adenocarcinoma; Adult; Aged; Anorexia Nervosa; Bone Diseases; Diphosphates; Female; Humans; Hyperparathyroidism; Hyperparathyroidism, Secondary; Middle Aged; Osteitis Deformans; Osteitis Fibrosa Cystica; Osteomalacia; Parathyroid Neoplasms; Radionuclide Imaging; Renal Dialysis; Technetium

The authors report the results they obtained by bone scintigraphy using technetium pyrophosphate. In a study of 142 patients with cancer, the authors show, as others have done, that bone scintigraphy makes it possible to find bone metastases that are radiologically undetectable and they emphasize the importance of this discovery. In 7 patients with spondylodiscitis, of whom 1 was without radiological signs at the time the scintigraphy was carried out, the authors always observed localized vertebral hyperfixation and they noted that this examination can be valuable for distinguishing spondylodiscitis from pseudo-Pott's discarthroses and from the lesions of vertebral epiphysitis, which in their experience do not result in isotopic hyperfixation. In 7 patients with epiphyseal osteonecrosis, the authors observed isotopic hyperfixation before the appearance of radiological signs. In 12 patients with osteoporosis, the authors observed hyperfixation in bone in certain compressed vertebrae, whereas other vertebrae that had probably been compressed some considerable time earlier did not fix the isotope excessively. They never observed hyperfixation in vertebrae that were not compressed. Among 5 patients with ankylosing spondylitis with radiological signs of sacro-iliac arthritis, the authors observed sacro-iliac hyperfixation in only 3 cases. Two other patients who had signs indicating ankylosing spondylarthritis, but were without radiological signs of sacro-iliac arthritis did not show sacro-iliac hyperfixation of the isotope. Among 7 patients with Paget's disease, the authors observed hyperfixation in all the bones with radiological signs of disease; in addition, in 3 patients, there was also hyperfixation in certain bones that were radiologically clear.

Topics: Bone Diseases; Bone Neoplasms; Diphosphates; Epiphyses, Slipped; Humans; Joint Diseases; Knee Joint; Neoplasm Metastasis; Osteitis Deformans; Osteoarthritis; Osteoporosis; Radiography; Radionuclide Imaging; Spinal Diseases; Spondylitis; Spondylitis, Ankylosing; Technetium

Topics: Chemical Phenomena; Chemistry; Diphosphates; Humans; In Vitro Techniques; Methods; Organophosphonates; Osteitis Deformans; Time Factors

Topics: Adolescent; Aged; Bone Neoplasms; Diphosphates; Female; Humans; Male; Middle Aged; Osteitis Deformans; Radionuclide Imaging; Technetium

Topics: Aged; Diagnosis, Differential; Diphosphates; Female; Hematoma, Subdural; Humans; Male; Middle Aged; Osteitis Deformans; Radionuclide Imaging; Skull; Technetium

Topics: Arthritis; Bone Diseases; Bone Neoplasms; Diagnosis, Differential; Diphosphates; Hodgkin Disease; Humans; Multiple Myeloma; Neoplasm Metastasis; Osteitis Deformans; Osteoarthritis; Osteolysis; Osteomalacia; Osteoporosis; Radionuclide Imaging; Reflex Sympathetic Dystrophy; Rheumatic Diseases; Technetium; Tin

Topics: Adolescent; Adult; Aged; Bone Diseases; Child; Child, Preschool; Diphosphates; Female; Humans; Hydroxyproline; Hyperparathyroidism; Hyperthyroidism; Male; Middle Aged; Osteitis Deformans; Osteomalacia; Osteoporosis; Parathyroid Glands; Phosphorus Isotopes

Topics: Bone and Bones; Calcium; Dental Caries; Diphosphates; Homeostasis; Hydroxyapatites; Hyperparathyroidism; Hyperthyroidism; Hypophosphatasia; Osteitis Deformans; Osteoporosis; Phosphates; Saliva; Solubility

Topics: Bone Neoplasms; Bone Resorption; Chromatography; Diphosphates; Fluids and Secretions; Humans; Hydroxyproline; Hyperparathyroidism; Hyperthyroidism; Osteitis Deformans; Phosphorus; Urine