pyrophosphate and Organophosphate-Poisoning

Topics: Atropine; Cats; Cell Respiration; Cholinesterase Inhibitors; Diphosphates; Dogs; Isoflurophate; Organophosphate Poisoning; Parathion; Phosphorus; Poisons; Research; Respiration; Seizures; Toxicology

Topics: Atropine; Child; Diphosphates; Drug-Related Side Effects and Adverse Reactions; Organophosphate Poisoning; Oximes; Parathion; Phosphorus; Poisons; Pralidoxime Compounds; Pyridines; Toxicology

Topics: Amphetamine; Atropine; Cholinesterase Inhibitors; Cholinesterases; Dextroamphetamine; Diphosphates; Enzyme Inhibitors; Hexobarbital; Hydrazines; Hypnotics and Sedatives; Iproniazid; Mice; Organophosphate Poisoning; Oximes; Parasympatholytics; Parathion; Perphenazine; Pharmacology; Phosphorus; Poisons; Pralidoxime Compounds; Pyridines; Research

The soluble methanesulphonate of the oxime 2-hydroxyiminomethyl-N-methylpyridinium (P2S) has been used to treat animals poisoned with sarin or ethyl pyrophosphate. The effect of the size of the dose, and its time of administration in relation to poisoning, have been examined. This oxime is very efficient in conjunction with atropine when given either before or after poisoning. About 30 mg./kg. seems to be the optimum therapeutic dose of the methanesulphonate. The significance of this optimum is discussed in relation to the treatment of accidental poisoning by organophosphate insecticides in man.

Topics: Animals; Atropine; Diphosphates; Humans; Insecticides; Male; Mesylates; Organophosphate Poisoning; Oximes; Phosphates; Pralidoxime Compounds; Pyrans; Pyridinium Compounds; Sarin

Topics: Diphosphates; Organophosphate Poisoning; Parathion