pyrophosphate and Nervous-System-Diseases

Topics: Animals; Body Mass Index; Bone Diseases; Chemical Industry; Diphosphates; Erythrocytes; Female; Fertilizers; Humans; Leukocytes; Male; Mice; Muscular Diseases; Nervous System Diseases; Occupational Diseases

Topics: Diagnosis, Differential; Diphosphates; Hand; Humans; Nervous System Diseases; Occupational Diseases; Radionuclide Angiography; Technetium; Technetium Tc 99m Pyrophosphate; Vascular Diseases; Vibration

Twelve patients with familial amyloidosis with polyneuropathy were examined both by cross sectional echocardiography and by technetium-99m pyrophosphate scintigraphy to assess involvement of the heart non-invasively. All 12 patients had echocardiographic abnormalities. The most prominent findings were highly refractile myocardial echoes, thickened heart valves, and increased thickness of the heart walls. Four patients had abnormal myocardial uptake of technetium-99m pyrophosphate. The remaining eight had equivocal or no myocardial uptake and were considered to have normal scintigrams. A certain amount of amyloid is probably required to produce an abnormal scintigram, although lesions with less amyloid can evidently be identified by echocardiography. Neither the duration of polyneuropathy nor its severity showed any relation to the echocardiographic or scintigraphic findings. It is concluded that cross sectional echocardiography is superior to technetium-99m pyrophosphate scintigraphy in detecting cardiac involvement in familial amyloidosis with polyneuropathy and that these results may also be applicable to other forms of amyloidosis.

Topics: Adult; Aged; Amyloidosis; Diphosphates; Echocardiography; Female; Heart; Heart Diseases; Humans; Male; Middle Aged; Nervous System Diseases; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate

99MTc pyrophosphate has restored bone scintigraphy to the position of respectability it had lost with radiostrontium 85 and 87m, and it has rapidly become the method of choice for the detection of osteogenic hyperactivity. In cases of tumor the histologic disorder is frequently detected prior to the morphologic changes seen in X-ray pictures. The biophysical properties of 99mTc pyrophosphate provide high quality imaging of the skeleton. The scans or scintiphotos render possible a more sensitive and earlier diagnosis than radiography, though bone scanning does not of course supersede radiography. The two methods are complementary. In present day oncologic practice, however, bone scintigraphy with 99mTc pyrophosphate replaces to advantage the conventional radiographic "bone survey". In neurology the change is already appreciable and has proved its worth. In the light of results in 78 neurologic patients attention is drawn to the significant changes bone scintigraphy has brought about in diagnosis and therapeutic planning. The indications which have already emerged from this new method of nuclear neurology are tabulated, discussed and illustrated.

Topics: Adult; Aged; Bone Neoplasms; Diagnosis, Differential; Diphosphates; Female; Fractures, Bone; Histiocytoma, Benign Fibrous; Humans; Male; Neoplasm Metastasis; Nervous System Diseases; Radionuclide Imaging; Skull Neoplasms; Technetium

Topics: Acetates; Animals; Cadmium; Cricetinae; Diphosphates; Ganglia, Spinal; Glutathione; Guinea Pigs; Iron-Dextran Complex; Mice; Nervous System Diseases; Rats; Trigeminal Nerve

Topics: Animals; Demyelinating Diseases; Diphosphates; In Vitro Techniques; Isoflurophate; Mice; Myelin Sheath; Nerve Degeneration; Nervous System Diseases; Pharmacology; Research