pyrophosphate and Nephrocalcinosis

pyrophosphate has been researched along with Nephrocalcinosis* in 5 studies

Reviews

1 review(s) available for pyrophosphate and Nephrocalcinosis

Article	Year
Extracellular pyrophosphate in the kidney: how does it get there and what does it do?. Nephron. Physiology, 2012, Volume: 120, Issue:4 Pyrophosphate (PPi) is well known as a regulator of calcification, and the ANKH (ANK in mouse) protein has a role in the membrane transport of PPi. Earlier work concentrated on bones and joints, but ANKH is also likely to have important roles in the kidney, with newer studies focusing on vascular calcification in renal failure. Renal calcification can occur due to a naturally occurring ANK mouse mutation, yet other ANK mutations do not cause a renal phenotype. Despite evidence over 10 years of ANKH's involvement in PPi transport, efflux of PPi via ANKH has never been demonstrated. Rather than physically moving PPi, the ANKH protein may assist its membrane transport in other ways such as by hydrolysis and compartmentalisation. Protein complexes may account for effects of ANKH that are specific to particular tissues. In the kidney, recent localisation data may be helpful in suggesting physiological roles for ANKH, such as its co-localisation with aquaporin-2 and cilial proteins. Such diverse functions would reflect the ubiquitous nature of ANKH in tissues and its profound evolutionary conservation. Topics: Animals; Aquaporin 2; Calcinosis; Cilia; Diphosphates; Humans; Kidney; Membrane Transport Proteins; Mice; Mutation; Nephrocalcinosis; Organ Specificity; Phosphate Transport Proteins; Renal Insufficiency	2012

Article

Year

Extracellular pyrophosphate in the kidney: how does it get there and what does it do?.

Nephron. Physiology, 2012, Volume: 120, Issue:4

Pyrophosphate (PPi) is well known as a regulator of calcification, and the ANKH (ANK in mouse) protein has a role in the membrane transport of PPi. Earlier work concentrated on bones and joints, but ANKH is also likely to have important roles in the kidney, with newer studies focusing on vascular calcification in renal failure. Renal calcification can occur due to a naturally occurring ANK mouse mutation, yet other ANK mutations do not cause a renal phenotype. Despite evidence over 10 years of ANKH's involvement in PPi transport, efflux of PPi via ANKH has never been demonstrated. Rather than physically moving PPi, the ANKH protein may assist its membrane transport in other ways such as by hydrolysis and compartmentalisation. Protein complexes may account for effects of ANKH that are specific to particular tissues. In the kidney, recent localisation data may be helpful in suggesting physiological roles for ANKH, such as its co-localisation with aquaporin-2 and cilial proteins. Such diverse functions would reflect the ubiquitous nature of ANKH in tissues and its profound evolutionary conservation.

Topics: Animals; Aquaporin 2; Calcinosis; Cilia; Diphosphates; Humans; Kidney; Membrane Transport Proteins; Mice; Mutation; Nephrocalcinosis; Organ Specificity; Phosphate Transport Proteins; Renal Insufficiency

2012

Other Studies

4 other study(ies) available for pyrophosphate and Nephrocalcinosis

Article	Year
Presence or absence of inhibitor of calcium-oxalate crystal growth in urine of normals and of stoneformers. Lancet (London, England), 1971, Oct-09, Volume: 2, Issue:7728 Topics: Acidosis, Renal Tubular; Adult; Calcium; Cystinuria; Diphosphates; Female; Humans; Hyperparathyroidism; Male; Nephrocalcinosis; Oxalates; Peptides; Urinary Bladder Calculi	1971
[On the inhibitory effect of phosphate compounds on experimental vascular calcinosis]. Beitrage zur pathologischen Anatomie und zur allgemeinen Pathologie, 1969, Volume: 139, Issue:1 Topics: Animals; Aorta; Arteries; Calcinosis; Coronary Vessels; Dihydrotachysterol; Diphosphates; Female; Glycerophosphates; Histological Techniques; Injections, Intraperitoneal; Injections, Subcutaneous; Kidney; Myocardium; Nephrocalcinosis; Phosphates; Phosphoric Monoester Hydrolases; Pulmonary Artery; Rats; Vascular Diseases	1969
[Influence of diphosphonates on the deposition and dissolution ofccalcium phosphate in vitro and in vivo]. Helvetica physiologica et pharmacologica acta, 1968, Volume: 26, Issue:3 Topics: Animals; Aorta; Calcinosis; Calcium Phosphates; Culture Techniques; Depression, Chemical; Diphosphates; Mice; Models, Biological; Nephrocalcinosis; Organophosphonates; Rats	1968
EFFECT OF ORAL PYRO- AND TRIPOLYPHOSPHATE ON RAT UROLITHIASIS. Investigative urology, 1965, Volume: 2 Topics: Chemical Precipitation; Crystallization; Diphosphates; Kidney Calculi; Kidney Tubules; Milk; Nephrocalcinosis; Pathology; Pharmacology; Phosphates; Polyphosphates; Rats; Research; Solubility; Toxicology; Urinary Calculi; Urolithiasis	1965