pyrophosphate and Monkey-Diseases

Calcium pyrophosphate dihydrate crystal deposition disease (CPDD) was recognized in 4 of 30 free-ranging rhesus macaques. By means of tissue radiography, focal radiodensities were noted in lumbar intervertebral discs, menisci, and articular cartilage. Crystal deposits were identified as calcium pyrophosphate dihydrate (Ca2P2O7 X 2H2O) by means of X-ray diffraction. The pathogenesis of calcium pyrophosphate dihydrate arthropathy in man remains elusive. However, with the recognition of this arthritis in a well defined population of aged nonhuman primates, a model now exists to facilitate the study of this disease.

Topics: Animals; Animals, Wild; Calcinosis; Calcium Pyrophosphate; Connective Tissue Diseases; Diphosphates; Macaca mulatta; Monkey Diseases; Radiography; X-Ray Diffraction

Topics: Animals; Calcium Pyrophosphate; Cartilage Diseases; Diphosphates; Disease Models, Animal; Humans; Macaca mulatta; Microscopy, Electron, Scanning; Monkey Diseases

Naturally occurring deposition of calcium pyrophosphate has been identified in six rhesus monkeys following acute episodes of trauma and various septicemias. Scanning electron microscopy with energy-dispersive X-ray analytical system and single crystal electron diffraction studies were used to identify the crystals within the articular cartilage. The osteoarthritis grading system was used to determine the degree of cartilage degenerative changes.

Topics: Animals; Calcium Pyrophosphate; Cartilage Diseases; Cartilage, Articular; Diphosphates; Female; Knee Joint; Macaca mulatta; Male; Microscopy, Electron, Scanning; Monkey Diseases; Osteoarthritis; Synovitis; X-Ray Diffraction

Topics: Animals; Calcium Metabolism Disorders; Calcium Pyrophosphate; Diphosphates; Exostoses; Female; Macaca; Monkey Diseases; Spinal Diseases