pyrophosphate and Mitral-Valve-Stenosis

pyrophosphate has been researched along with Mitral-Valve-Stenosis* in 2 studies

Other Studies

2 other study(ies) available for pyrophosphate and Mitral-Valve-Stenosis

ArticleYear
[Endoluminal mitral valvuloplasty in young adults and children. Apropos of 10 cases].
    Archives des maladies du coeur et des vaisseaux, 1987, Volume: 80, Issue:8

    Between April 1 and May 15, 1986, transluminal dilatation of the mitral valve was performed at the Marie-Lannelongue Hospital, near Paris, in 10 patients aged from 12 to 48 years (mean 25,3 years) suffering from rheumatic mitral stenosis with supple valve leaflets. The procedure, carried out under local anaesthesia, included trans-septal catheterization followed by installation of one, then usually two balloons opposite the mitral orifice. The total diameter of the balloons was often greater than that of the mitral annulus. No haemorrhage, embolism or arrhythmia was observed. A significant left-to-right shunt, evaluated by radioisotope exploration with technetium pyrophosphate performed on the 8th day, was present in only one patient. The LV-LA end-diastolic gradient fell from 14.4 +/- 9.8 to 4.6 +/- 3.4 mmHg (p less than 0.01). The mean pulmonary arterial pressure was reduced less significantly from 39.9 +/- 18.4 to 27.2 +/- 11.3 mmHg (p less than 0.02). The cardiac output was only moderately increased from 2.52 +/- 0.48 to 2.88 +/- 0.66 l/min/m2. The mitral valve area, measured from the smaller axis on 2-dimensional echocardiography, more than doubled, reaching a mean value of 1.99 +/- 0.56 cm2. This figure was confirmed by the reduction, at Doppler velocimetry, of the gradient half-regression time from 267 +/- 62 to 118 +/- 46 ms (p less than 0.01). Similarly, the end-systolic gradient evaluated by Doppler, fell from 17.5 +/- 8.9 to 5.3 +/- 4.7 mmHg (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

    Topics: Adolescent; Adult; Anesthesia, Local; Cardiac Catheterization; Catheterization; Diphosphates; Echocardiography; Female; Humans; Male; Mitral Valve; Mitral Valve Stenosis; Radioisotope Dilution Technique; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate

1987
Relationship between the myofibrillar ATPase activity of human biopsy material and hemodynamic parameters.
    Japanese heart journal, 1985, Volume: 26, Issue:6

    The myofibrillar ATPase activity and pyrophosphate gel electrophoretic pattern of native myosin of fresh human left ventricular papillary muscles were examined in 52 cases of mitral valve replacement. The myofibrillar ATPase activity of hypertrophied myocardium did not differ from that of non-hypertrophied myocardium (mean +/- SD, 36.2 +/- 8.7 vs 31.8 +/- 8.6 nmolPi/mg/min, ns) and there was no significant difference in myofibrillar ATPase activity as a function of left ventricular enddiastolic pressure. Pyrophosphate gel electrophoresis of myosin revealed the presence of two components. It is questionable whether the component of higher electrophoretic mobility (approximately 25-35% in concentration) is identical with rat ventricular myosin VM-1 because an increase in this component seems to correlate with a decrease of myofibrillar ATPase activity, its concentration was significantly higher in the hearts with left ventricular hypertrophy, high enddiastolic pressure, high aortic pressure or low cardiac index. From these results, it is not necessarily clear whether hemodynamic overload in valvular heart diseases can alter left ventricular myofibrillar ATPase activity, but it can be said that the overload influences the concentration of the two components of native myosin revealed by pyrophosphate gel electrophoresis.

    Topics: Adenosine Triphosphatases; Age Factors; Biopsy; Calcium; Diphosphates; Electrophoresis; Enzyme Activation; Heart Ventricles; Hemodynamics; Humans; Mitral Valve Insufficiency; Mitral Valve Stenosis; Myocardium; Myofibrils; Myosins; Papillary Muscles

1985
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