pyrophosphate and Hodgkin-Disease

The observation by Subramanian and his co-workers that a 99mTc-labeled polyphosphate had excellent affinity for bone has led to widespread use of 99mTc-labeled phosphates as bone scanning agents. Initially, only polyphosphate was employed, but because of somewhat inconstant results and difficulty in preparation of this product, other phosphate compounds were sought. We soon discovered that an inorganic compound, pyrophosphate, appeared to have certain advantages over polyphosphate. Other workers formulated diphosphonates (organic phosphates) which also demonstrated advantages over polyphosphates. Comparison studies in rabbits utilizing 85Sr, 87mSr, 18F, and several phosphates (inorganic and organic) proved the 99mTc-labeled phosphates to be clearly superior in delineating normal skeletal anatomy. Studies in humans confirmed that excellent visualization of bone was obtained with 99mTc-labeled phosphates using either a gamma camera or a rectilinear scanner. What was not known, however, was just how reliable this class of agents would prove to be in detecting bone disease when compared to bone-seeking radiopharmaceuticals such as 85Sr, 87mSr, and 18F. Further comparative analyses have clearly demonstrated that both inorganic and organic 99mTc phosphate complexes are extremely sensitive in revealing more bone disease than the older bone scanning agents.

Topics: Adult; Aged; Animals; Bone Neoplasms; Breast Neoplasms; Carcinoma, Squamous Cell; Colonic Neoplasms; Diphosphates; Female; Fluorine; Hodgkin Disease; Humans; Kidney Neoplasms; Lung Neoplasms; Male; Middle Aged; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Phosphates; Prostatic Neoplasms; Rabbits; Radioisotopes; Radionuclide Imaging; Strontium Radioisotopes; Technetium

Osteoscintigraphy and dynamic scintigraphy of the kidneys with 99mTc-pyrophosphate were used for investigation of 24 pediatric patients with tumorous involvement of the retroperitoneal space. Bone metastases were detected by osteoscintigraphy in 8 patients, pathological changes of the kidneys and urinary tract in 9 patients. Dynamic investigation of the kidneys with 99mTc-pyrophosphate performed in the first 20 min. after the drug injection showed disorders of renal evacuatory function of a varied degree of expression in all 24 patients. Dynamic investigation of the kidneys with 99mTc-pyrophosphate was not accompanied by an increase in radiation exposures therefore it was recommended at the first stage of radionuclide investigation of children with tumorous involvement of the retroperitoneal space followed by osteoscintigraphy.

Topics: Adult; Bone Neoplasms; Child; Child, Preschool; Diphosphates; Hodgkin Disease; Humans; Infant; Kidney Neoplasms; Neuroblastoma; Radioisotope Renography; Retroperitoneal Neoplasms; Technetium; Technetium Tc 99m Pyrophosphate; Wilms Tumor

A total of 401 patients: 148 men, 134 women and 119 children with Hodgkin's disease were examined to determine the diagnostic value of the radioisotope and x-ray methods in the early detection of metastatic involvement of the skeletal bones. Specific skeletal bone lesions were revealed in 72 patients. Metastatic lesions of the skeletal bones develop more frequently in adults than in children. No significant differences in the site of metastases were noted. Radioisotope examination is an earlier diagnostic method in the early detection of metastatic involvement of the skeletal bones in Hodgkin's disease and more informative in the diagnosis of costal and cranial bone lesions.

Topics: Adolescent; Adult; Aged; Bone Neoplasms; Child; Child, Preschool; Diphosphates; Female; Hodgkin Disease; Humans; Male; Middle Aged; Radiography; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate

Topics: Diphosphates; Hodgkin Disease; Humans; Kidney; Radioisotope Renography; Technetium; Whole-Body Counting

Topics: Biopsy; Bone Neoplasms; Diphosphates; Hodgkin Disease; Humans; Radiography; Radionuclide Imaging; Technetium

To assess the degree of tumor proliferation radionuclide studies were performed in 187 patients with lymphogranulomatosis. Scintigraphy was conducted with 99mTc-pyrophosphate and 99mTc-sulfur colloid on gammer chambers FO GAMMA LFOV and OH 110 subsequently followed by processing a scintigraphic image on special-purpose computers CDP 11/34 and OH DC 160. The signs of bone affection revealed by 99mTc-pyrophosphate were supported in 86% of cases roentgenotomographically and histologically. A correlation between scintigraphic findings and the results of morphological studies in 45 patients showed a coincidence of the results in 93% of the cases with scintigraphy of the liver and in 81% of cases with radionuclide examination of the spleen by 99mTc-sulfur colloid. A statistical analysis has indicated that scintigraphic findings are consistent with histological ones qualitatively, the probability value being p > 0.999 (X2 = 15.35).

Topics: Colloids; Diphosphates; Hodgkin Disease; Humans; Radionuclide Imaging; Sulfur; Technetium

Of 70 consecutive cancer patients referred from radiotherapy for bone scans, 32% showed cardiac uptake of 99mTc-(Sn)-pyrophosphate; only 9% of a control group showed this uptake. Of those with prior left hemithorax irradiation, 60% showed cardiac uptake; only 12% of those with irradiation elsewhere showed this phenomenon (p less than .01). The patients who had no increased uptake tended to have shorter irradiation-to-scan time intervals (less than 10 months) than those who did show increased uptake (mean of 22 months).

Topics: Adult; Aged; Bone Neoplasms; Breast Neoplasms; Diphosphates; Female; Hodgkin Disease; Humans; Lung Neoplasms; Male; Middle Aged; Myocardium; Radionuclide Imaging; Radiotherapy; Technetium; Thorax

Topics: Adult; Bone Neoplasms; Diphosphates; Hodgkin Disease; Humans; Male; Radionuclide Imaging; Technetium

Topics: Adolescent; Adult; Aged; Bone Neoplasms; Child; Diphosphates; Female; Giant Cell Tumors; Hodgkin Disease; Humans; Male; Middle Aged; Osteoma, Osteoid; Radionuclide Imaging; Sarcoma; Technetium

Topics: Arthritis; Bone Diseases; Bone Neoplasms; Diagnosis, Differential; Diphosphates; Hodgkin Disease; Humans; Multiple Myeloma; Neoplasm Metastasis; Osteitis Deformans; Osteoarthritis; Osteolysis; Osteomalacia; Osteoporosis; Radionuclide Imaging; Reflex Sympathetic Dystrophy; Rheumatic Diseases; Technetium; Tin

Topics: Bone Diseases; Bone Neoplasms; Diphosphates; Hodgkin Disease; Humans; Methods; Polymers; Radionuclide Imaging; Strontium Isotopes; Technetium