pyrophosphate and Herpes-Simplex

We investigated the influence of disodium phosphonic formate (PFA-Na2) and trisodium thiophosphonic formate (TPFA-Na3), in comparison with acyclovir (Zovirax) and trisodium phosphonic formate (PFA-Na3) (Triapten) ointment, on the course of primary cutaneous herpes simplex virus infection in a guinea pig skin model. PFA-Na2 at 3.0%, TPFA-Na3 at 0.5% and PFA-Na3 at 0.5% as well as Triapten ointment (2.0% PFA-Na3) completely inhibited virus infection. Zovirax cream (5.0% acyclovir), applied five times (15 min., 4, 20, 24, and 28 h) after virus inoculation did not prevent virus infection. Similarly, application of Zovirax cream 5 times daily for 5 days did not prevent a vesicle formation following cutaneous herpes simplex virus infection of the guinea pig.

Topics: Acyclovir; Animals; Diphosphates; Female; Guinea Pigs; Herpes Simplex; Male; Simplexvirus; Skin Diseases, Infectious

Two broad categories of combinations have been subject to experimental investigation against HSV-1 and HSV-2; those consisting of an active antiviral drug and an inhibitor of its catabolism and those which contain two active antiviral agents. The latter seek to exploit biochemical mechanisms likely to lead to a synergistic or complementary interaction. Examples of both types of combination for the suppression of resistance development and for the treatment of infection caused by resistant strains are discussed. Their possible relevance to the latent state is considered.

Topics: Acyclovir; Adenosine Deaminase Inhibitors; Animals; Antiviral Agents; Diphosphates; Drug Resistance, Microbial; Drug Synergism; Drug Therapy, Combination; Foscarnet; Herpes Simplex; In Vitro Techniques; Nucleic Acid Synthesis Inhibitors; Phosphonoacetic Acid; Simplexvirus; Thymidine Kinase; Uridine Phosphorylase; Vidarabine