pyrophosphate and Gastrointestinal-Hemorrhage

Massive lower gastrointestinal bleeding is described in two patients with Crohn's disease. In case 1, extravasation of contrast material from the ileal branch of the ileocolic artery was seen during selective angiography. In case 2, results of an in vitro labeled 99Tc pyrophosphate red blood cell scan localized bleeding to the ileum. In both cases, medical management was unsuccessful, and surgical resection of the affected bowel was required to stop the bleeding. Angiographic appearance of Crohn's disease is discussed, and a review of the literature of this unusual feature of Crohn's disease is presented.

Topics: Adult; Angiography; Cecum; Crohn Disease; Diphosphates; Extravasation of Diagnostic and Therapeutic Materials; Female; Gastrointestinal Hemorrhage; Humans; Ileitis; Ileum; Male; Radionuclide Imaging; Recurrence; Technetium; Technetium Tc 99m Pyrophosphate

Topics: Adult; Colonic Diseases; Diphosphates; Erythrocytes; Factitious Disorders; Female; Gastrointestinal Hemorrhage; Humans; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate

We report on three cases of intestinal bleeding detected by nuclear imaging using 99mTc pyrophosphate in vivo-labelled red blood cells.

Topics: Aged; Aged, 80 and over; Diagnosis, Differential; Diagnostic Imaging; Diphosphates; Female; Gastrointestinal Hemorrhage; Hemangioma; Humans; Ileal Neoplasms; Meckel Diverticulum; Mesenteric Arteries; Radiography; Sigmoid Neoplasms; Subtraction Technique; Technetium; Technetium Tc 99m Pyrophosphate

Two cases in which gastrointestinal bleeding was localized by serial scintigraphic imaging with red blood cells labeled in vivo with 99mTc-PYP are reported. The importance of both early serial imaging and delayed imaging and of the correlation with other radiographic techniques is demonstrated. Reflux of blood from the sigmoid into the proximal colon was observed in both cases. In one case, contrast material injected into a resected specimen confirmed the scintigraphic localization of the site of bleeding.

Topics: Aged; Diphosphates; Erythrocytes; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Radiography; Radionuclide Imaging; Technetium; Time Factors

Topics: Adult; Aged; Diphosphates; Erythrocytes; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate

Topics: Aged; Diphosphates; Gastrointestinal Hemorrhage; Humans; Ileal Neoplasms; Leiomyoma; Male; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate