pyrophosphate and Fractures--Closed

Topics: Animals; Diphosphates; Dogs; Fracture Fixation, Internal; Fractures, Closed; Humeral Fractures; Technetium; Technetium Tc 99m Pyrophosphate; Wound Healing

Altogether 56 patients aged 20-55 with closed oblique fractures of the upper and lower limb bones were observed. Reparative osteogenesis was studied using 99mTc-pyrophosphate. An elevated RP accumulation at the ends of the bone splinters was found from the 1st day after fracture. By the end of the 1st month after fracture the RP activity increased up to 750% in the absence of splinter dislocation. In dislocation it was 50-80% less. The RP maximal activity in the place of fracture was noted on the 7-8th week, in the dislocation of splinters on the 9-10th week. By the results of radionuclide studies, the fracture consolidated right after a decrease in the 99mTc-pyrophosphate accumulation that made it possible to determine the optimum time of bone consolidation.

Topics: Adult; Arm Injuries; Diphosphates; Fracture Fixation, Internal; Fractures, Bone; Fractures, Closed; Humans; Leg Injuries; Middle Aged; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate; Wound Healing

A total of 86 patients were examined by 99mTc-pyrophosphate in the course of therapy using the transosseous synthesis method. An elevated accumulation of the radiopharmaceutical was observed since the first day following a trauma. Maximum enhancement of metabolic processes in the absence of fragment displacement was noted on the 8th week and in the lack of displacement on the 9th-10th week. Then the intensity of bone formation got weaker. It was found appropriate that G. A. Ilizarov's apparatus should be removed exactly at that time. The content of mineral components in the regenerate was over 60% which demonstrated the bone ability to stand physiological loads.

Topics: Adult; Arm Injuries; Diphosphates; Fracture Fixation, Internal; Fractures, Bone; Fractures, Closed; Humans; Leg Injuries; Middle Aged; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate; Wound Healing

A study was made of reparative osteogenesis and the content of mineral bone components in 60 patients with spiral fractures of the leg bones during treatment by transosseous osteosynthesis. The time of maximum labeled pyrophosphate accumulation was determined by a degree of the initial dislocation of fragments: in the dislocation to the cortical layer it was noted on the 42nd day, by 1/3 on the 45th day, by 2/3 on the 50th day, to the cross section on the 60th day. The demineralization of bone fragments in the dislocation to the cortical layer was 34%, by 1/2 37%, by 2/3 41% and to the cross section by 44%. The labeled sulphuric colloid accumulation by bone marrow cells was maximal in minimal dislocations and decreased with growing dislocation.

Topics: Adult; Bone and Bones; Bone Marrow; Diphosphates; Fracture Fixation, Internal; Fractures, Bone; Fractures, Closed; Humans; Leg Injuries; Middle Aged; Minerals; Orthopedic Fixation Devices; Osteogenesis; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate; Technetium Tc 99m Sulfur Colloid; Time Factors

The potential role of bone scanning in the early detection of occult fractures following acute trauma was investigated. Technetium 99m pyrophosphate bone scans were obtained in patients with major clinical findings (e.g., pain, swelling, tenderness) and negative or equivocal roentgenograms following trauma. Bone scanning facilitated the prompt diagnosis of occult fractures in the hip, knee, wrist, ribs and costochondral junctions, sternum, vertebrae, sacrum, and coccyx. Several illustrative cases are presented. Roentgenographic confirmation occurred following a delay of days to weeks and, in some instances, the roentgenographic findings were subtle and could be easily overlooked. This study demonstrates bone scanning to be invaluable and definitive in the prompt detection of occult fractures.

Topics: Acetabulum; Aged; Bone and Bones; Coccyx; Diphosphates; Female; Fractures, Bone; Fractures, Closed; Humans; Radiography; Radionuclide Imaging; Radius Fractures; Sacrum; Sternum; Technetium; Technetium Tc 99m Pyrophosphate; Wounds and Injuries; Wrist Injuries