pyrophosphate and Cardiomyopathy--Dilated

Topics: Amyloid Neuropathies, Familial; Cardiomyopathy, Dilated; Diagnosis, Differential; Diphosphates; Female; Heart Failure; Humans; Middle Aged; Radionuclide Imaging; Technetium; Tomography, Emission-Computed, Single-Photon

Assessment of myocardial contractility function and its diastolic features (according to the results of radionuclide ventriculography with 99mTc-pertechnetate) in patients with dilatory cardiomyopathy (DCMP) revealed a significant decrease in the total ejection fraction, regional ejection fractions, cardiomegaly (an increase in the end-diastolic volume combined with an increase in end-systolic volume and a decrease in the stroke volume) and a decrease in ejection rate indices. Differential criteria for the diagnosis of DCMP and CHD were a greater degree of cardiodynamic indices and a diffuse decrease in myocardial regional contractility function in the former and heterogeneity of changes in regional contractility in the latter pathology. The process of diastolic filling in DCMP patients was characterized by a marked decrease in a filling rate at reduced time of its achievement, and in CHD patients by a decrease in a maximum filling rate in combination with increased time of its achievement.

Topics: Adult; Cardiomyopathy, Dilated; Coronary Disease; Diagnosis, Differential; Diphosphates; Humans; Male; Middle Aged; Myocardial Contraction; Myocardial Infarction; Radionuclide Ventriculography; Sodium Pertechnetate Tc 99m; Technetium; Technetium Tc 99m Pyrophosphate

Predictive value of myocardial 99mTc-pyrophosphate scintigraphy was assessed in 122 patients with postinfarction cardiosclerosis. In those cases where clinical and scintigraphic complication risk estimates considered, further evidence was shown to be redundant. Prognosis in patients with positive scintigraphic results and asymptomatic postinfarction cardiosclerosis or first-to-second class stable angina should take into account the size of myocardial pyrophosphate accumulation focus and the pattern of stress-induced changes in blood supply of the sites of myocardial damage. Negative scintigraphic results have no predictive value in those postinfarction cardiosclerosis patients who show clinical signs of heart failure and/or severe coronary insufficiency at the time of investigation.

Topics: Adult; Aged; Cardiomyopathy, Dilated; Diphosphates; Female; Heart; Humans; Male; Middle Aged; Myocardial Infarction; Prognosis; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate

Myocardial pyrophosphate accumulation was examined in various forms of coronary heart disease. The status of the coronary reserve in the myocardial lesion foci where pyrophosphate is accumulated has been shown to determine the severity of coronary failure in various uncomplicated forms of the disease, such as angina without prior myocardial infarction, myocardial infarction in the early phase of its healing, and postinfarction cardiosclerosis. In postinfarction cardiosclerosis, the dimensions of such foci are significant in the development of clinical events of coronary failure.

Topics: Aged; Angina Pectoris; Cardiomyopathy, Dilated; Coronary Disease; Diphosphates; Female; Humans; Male; Middle Aged; Myocardial Infarction; Radionuclide Imaging; Severity of Illness Index; Technetium; Technetium Tc 99m Pyrophosphate

Nuclear angiography was used as a diagnostic aid and in monitoring the clinical course of a case of congestive cardiomyopathy in a dog. Serial examinations revealed progressively deteriorating values for left ventricular ejection fraction before the dog's death. This noninvasive technique can be an alternative to echocardiography for the evaluation of cardiac performance.

Topics: Animals; Cardiomyopathy, Dilated; Diphosphates; Dog Diseases; Dogs; Male; Myocardial Contraction; Radionuclide Imaging; Stroke Volume; Technetium; Technetium Tc 99m Aggregated Albumin; Technetium Tc 99m Pyrophosphate

A study of the relationship between the frequency of labelled pyrophosphate detection in the heart muscle and the incidence of clinical signs of heart failure or angina in 185 postmyocardial-infarction patients demonstrated that the distribution of patients with postinfarction cardiosclerosis among the positive and negative 99mTc-pyrophosphate scintigraphy groups was governed by the presence of heart failure in these patients, a finding suggestive of the scarry fields within the myocardium as the principal cause of myocardial accumulation of labelled pyrophosphate in postinfarction cardiosclerosis. Pyrophosphate accumulation in patients with postinfarction cardiosclerosis can be regarded as an indicator of unfavorable developments, as confirmed by one-year follow-up results in 114 patients.

Topics: Adult; Aged; Cardiomyopathy, Dilated; Diphosphates; Endomyocardial Fibrosis; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardium; Prognosis; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate

Topics: Angiography; Cardiomyopathy, Dilated; Diphosphates; Electrocardiography; Exercise Test; Heart Diseases; Heart Valve Diseases; Humans; Isoenzymes; Myocardial Infarction; Perfusion; Prognosis; Radioisotopes; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate; Thallium