pyrophosphate and Carcinoma

Topics: Bone and Bones; Bone Neoplasms; Breast Neoplasms; Carcinoma; Diphosphates; Diphosphonates; Fractures, Bone; Humans; Lung Neoplasms; Male; Osteomyelitis; Prostatic Neoplasms; Radionuclide Imaging; Technetium; Technetium Compounds; Technetium Tc 99m Medronate; Technetium Tc 99m Pyrophosphate

Topics: Carcinoma; Diphosphates; Female; Humans; Liver Neoplasms; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate; Thyroid Neoplasms

Topics: Adult; Carcinoma; Diphosphates; Diphosphonates; Etidronic Acid; Female; Humans; Male; Middle Aged; Organotechnetium Compounds; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Technetium Tc 99m Pyrophosphate; Thyroid Neoplasms

Staging bone scans or skeletal surveys were obtained of 97 patients with endometrial carcinoma. Of the 77 patients with Stage I or II disease, no metastases were identified at staging. Three patients in the entire series demonstrated bony metastases; all of these metastases were detectable by radionuclide bone scan and radiographic bone survey. Eighty-nine patients were examined with radionuclide liver/spleen scanning at the time of staging. Four of the 89 initial scans were interpreted as demonstrating hepatocellular disease, and all four patients had abnormal liver function studies. Only one patient demonstrated a possible hepatic metastasis at initial diagnosis. This patient also had abnormal liver function studies. Based on these results, bone surveys and radionuclide bone scans are not indicated as screening procedures in endometrial carcinoma. It is suggested that screening for liver metastases in patients with endometrial carcinoma is not warranted in patients with normal liver function studies.

Topics: Bone Neoplasms; Carcinoma; Diphosphates; Diphosphonates; Female; Humans; Liver Neoplasms; Neoplasm Staging; Radionuclide Imaging; Sulfur; Technetium; Technetium Tc 99m Medronate; Technetium Tc 99m Sulfur Colloid; Uterine Neoplasms

Topics: Adenocarcinoma; Adenocarcinoma, Scirrhous; Adult; Bone Neoplasms; Breast Neoplasms; Carcinoma; Diphosphates; Female; Humans; Middle Aged; Neoplasm Metastasis; Radionuclide Imaging; Technetium

A total of 146 patients were investigated for the presence of osseous metastases with 99mTc polyphosphate or 99mTc pyrophosphate bone scans. Results of bone imaging were retrospectively compared to roentgenographic results surveying similar anatomic areas in 128 patients. This comparison revealed that roentgenographic interpretations were in error in 19% of the cases. Thirty-three patients had bone scans and roentgenograms that were in agreement and considered abnormal, but in more than one third of these cases the patients had multiple abnormalities that were shown by the bone scan but were not recognized roentgenographically. In consideration of the low toxicity, ready availability, economy, shortened procedure time, and low radiation dose associated with the use of these new bone-seeking agents, it is concluded that they are superior to roentgenograms and previously utilized radionuclides for early detection of osseous metastases.

Topics: Bone Neoplasms; Carcinoma; Diphosphates; Fluorine; Humans; Lung Neoplasms; Male; Neoplasm Metastasis; Phosphates; Prostatic Neoplasms; Radioisotopes; Radionuclide Imaging; Scintillation Counting; Strontium Radioisotopes; Urinary Bladder Neoplasms

Localization of 99mTc-pyrophosphate in the cardiac region during routine bone scanning for metastatic tumor is discussed in two cases. Clinical information as well as electrocardiographic and serum enzyme studies did not reveal any evidence of acute myocardial injury. The cause of myocardial localization of the radiopharmaceutical is not clear in these cases.

Topics: Aged; Bone Neoplasms; Breast Neoplasms; Carcinoma; Diphosphates; Female; Humans; Lung Neoplasms; Male; Middle Aged; Myocardial Infarction; Myocardium; Neoplasm Metastasis; Radioisotopes; Technetium

Topics: Base Sequence; Carcinoma; Cell Line; Cell Nucleus; Chromatography, Thin Layer; Diphosphates; DNA Nucleotidyltransferases; Electrophoresis, Paper; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Exonucleases; Humans; Isoelectric Focusing; Kinetics; Magnesium; Manganese; Molecular Weight; Mouth Neoplasms; Phosphorus Radioisotopes; Templates, Genetic; Tritium

Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adenoviridae; Carcinoma; Cell Fractionation; Cell Line; Cell Nucleus; Diphosphates; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Humans; Magnesium; Mouth Neoplasms; RNA, Messenger; RNA, Viral; Tritium; Uridine

Topics: Animals; Bone and Bones; Bone Neoplasms; Breast Neoplasms; Carcinoma; Diphosphates; Humans; Lung Neoplasms; Male; Melanoma; Neoplasm Metastasis; Prostatic Neoplasms; Radionuclide Imaging; Rectal Neoplasms; Sodium; Technetium; Time Factors; Urinary Bladder Neoplasms

Topics: Adenosine Diphosphate; Benzoates; Carcinoma; Cell Line; Cell Nucleus; Chromatography; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Cytoplasm; Diphosphates; DNA Nucleotidyltransferases; Electrophoresis; Humans; Hydroxyapatites; Isoelectric Focusing; Kinetics; Mouth Neoplasms; Polynucleotides; Templates, Genetic; Tritium

Topics: Adenine; Adenine Nucleotides; Animals; Carbohydrate Metabolism; Carcinoma; Carcinoma, Ehrlich Tumor; Dinitrophenols; Diphosphates; Glucose; Humans; In Vitro Techniques; Iodoacetates; Lactates; Methylene Blue; Pharmacology; Phosphoribosyl Pyrophosphate; Phosphotransferases; Research

Topics: Adenine; Animals; Carcinoma; Carcinoma, Ehrlich Tumor; Dinitrophenols; Diphosphates; Guanine; In Vitro Techniques; Iodoacetates; Metabolism; Methylene Blue; Nucleotides; Pharmacology; Phosphoribosyl Pyrophosphate; Research; Xanthines

Topics: Animals; Carbohydrate Metabolism; Carcinoma; Carcinoma, Ehrlich Tumor; Dinitrophenols; Diphosphates; Glucose; In Vitro Techniques; Iodoacetates; Lactates; Metabolism; Nucleosides; Pharmacology; Phosphoribosyl Pyrophosphate; Research; Ribonucleosides; Uridine

Topics: Adenine; Adenine Nucleotides; Animals; Antimetabolites; Carbon Isotopes; Carcinoma; Carcinoma, Ehrlich Tumor; Deoxyadenine Nucleotides; Diphosphates; Neoplasms, Experimental; Pharmacology; Phosphoribosyl Pyrophosphate; Phosphotransferases; Research

Topics: Animals; Carbon Isotopes; Carcinoma; Carcinoma, Ehrlich Tumor; Chromatography; Diphosphates; Ligases; Metabolism; Nucleosides; Orotic Acid; Pentosephosphates; Phosphoric Monoester Hydrolases; Phosphotransferases; Research; Tetrahymena; Tetrahymena pyriformis; Uracil Nucleotides; Yeasts

Topics: Adenosine Triphosphate; Animals; Ascites; Carbohydrate Metabolism; Carbohydrates; Carcinoma; Carcinoma, Ehrlich Tumor; Diphosphates; Erythrocytes; Glucose; Insulin; Metabolism; Neoplasms, Experimental; Pharmacology; Poultry; Research

Topics: Adenosine Triphosphate; Animals; Ascites; Carcinoma; Carcinoma, Ehrlich Tumor; Diphosphates; Mice; Radiation-Sensitizing Agents; Vitamin K