pyrophosphate has been researched along with Behcet-Syndrome* in 1 studies
1 other study(ies) available for pyrophosphate and Behcet-Syndrome
| Article | Year |
|---|---|
Vgamma9Vdelta2 T cells recovered from eyes of patients with Behçet's disease recognize non-peptide prenyl pyrophosphate antigens.
The phenotype and antigen-specificity of T cells expanded by mitogenic stimulation from intra-ocular fluid (IOF) samples of affected eyes of six Behçet's disease (BD) patients, and seven patients with other uveitis entities, were determined. High numbers of gammadelta T cells, predominantly Vgamma9Vdelta2 T cells, were only detected in the IOF-derived TCL of three BD patients. Whereas no TCL responded to heat shock protein (HSP) 65 kDa, reactivity to isopentyl pyrophosphate (IPP) and related non-peptide prenyl pyrophosphates (PPP) was restricted to the gammadelta T cell containing TCL. Upon IPP stimulation, these TCL secreted IFN-gamma but no IL-4. By single-cell analysis of intracellular IFN-gamma production and CD69 expression the IOF-derived IPP-specific T cells were identified as CD4(-)CD8(-) gammadelta T cells. The data presented suggest the infiltration of PPP-specific Vgamma9Vdelta2 Th1-like cells into the eye of BD patients with uveitis. Topics: Adult; Aged; Antigen Presentation; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Aqueous Humor; Behcet Syndrome; CD3 Complex; CD4-CD8 Ratio; Chemotaxis, Leukocyte; Child; Cytokines; Diphosphates; Epitopes; Eye; Female; Flow Cytometry; Humans; Interferon-gamma; Lectins, C-Type; Male; Middle Aged; Protein Prenylation; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes | 2002 |