Page last updated: 2024-09-02

pyronaridine and Malaria

pyronaridine has been researched along with Malaria in 62 studies

*Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia. [MeSH]

Research

Studies (62)

Timeframe	Studies, this research(%)	All Research%
pre-1990	26 (41.94)	18.7374
1990's	18 (29.03)	18.2507
2000's	6 (9.68)	29.6817
2010's	10 (16.13)	24.3611
2020's	2 (3.23)	2.80

Authors

Authors	Studies
Anstey, NM; Chalfein, F; Ebsworth, EP; Kenangalem, E; Marfurt, J; Piera, KA; Prasetyorini, B; Price, RN; Ratcliff, A; Russell, B; Siswantoro, H; Tjitra, E; Wuwung, M	1
Avery, VM; Baragaña, B; Campbell, SF; Delves, MJ; Duffy, S; Fairlamb, AH; Frearson, JA; Gilbert, IH; Gray, DW; Grimaldi, R; Hallyburton, I; Meister, S; Norcross, NR; Norval, S; Osuna-Cabello, M; Porzelle, A; Read, KD; Riley, J; Simeons, FR; Sinden, RE; Stojanovski, L; Waterson, D; Willis, P; Wilson, C; Winzeler, EA; Wittlin, S; Wyatt, PG	1
Aogo, RA; Cromer, D; Davenport, MP; Guy, RK; Haldar, RN; Haque, A; Khoury, DS; Lansink, LIM; McCarthy, JS; Romanczuk, AS; Salinas, YG; SheelaNair, A	1
Chu, WY; Dorlo, TPC	1
Clark, RL	1
Blessborn, D; Day, NPJ; Kaewkhao, K; Song, L; Tarning, J; White, NJ	1
Arbe-Barnes, S; Borghini-Fuhrer, I; Craft, CJ; Duparc, S; Fleckenstein, L; Miller, RM; Shin, CS	1
Auparakkitanon, S; Denny, WA; Rattanajak, R; Sereekhajornjaru, N; Somboon, C; Wilairat, P	1
Beavogui, AH; Bjorkman, A; Borghini-Fuhrer, I; Borrmann, S; Camara, D; Compaore, YD; Coulibaly, AS; Dara, N; Diallo, MS; Dicko, A; Djimdé, AA; Doumbo, OK; Duparc, S; Fofana, B; Gil, JP; Kabore, MJ; Miller, RM; Nikiema, F; Ouedraogo, JB; Sagara, I; Shin, J; Sirima, SB; Somé, AF; Soulama, I; Sylla, MM; Thera, I; Traore, OB; Zongo, I	1
Ayyoub, A; Borghini-Fuhrer, I; Djimde, AA; Duparc, S; Fleckenstein, L; Methaneethorn, J; Ramharter, M; Shin, JS; Tekete, M	1
Adjalley, SH; Eappen, AG; Eastman, RT; Ekland, EH; Fidock, DA; Hoffman, SL; Johnston, GL; Lee, MC; Li, T; Richman, A; Sim, BK	1
Jomaa, H; Ortmann, R; Schlitzer, M; Wiesner, J	1
Cai, Y; Chollet, J; Tanner, M; Utzinger, J; Xiao, SH; Yao, JM	1
Bongard, E; Croft, SL; Peters, W; Rattray, L; Robinson, BL; Stewart, L; Vivas, L	1
Chen, KY; Lin, BY; Shao, BR; Zhang, JX	3
Cao, SZ; Gao, SF; Huei, BL; Shen, SL; Wang, KS	1
Huang, RZ; Kang, WM; Liu, QH; Xi, YH; Xie, C; Xu, HQ; Yang, RZ; Ye, JS	1
Chen, KY; Lin, BY; Ye, XY; Zhang, JX; Zheng, H	1
Xu, YX	2
Lapierre, J	1
Chen, YD; Lin, BY; Pan, YR; Tang, WZ; Xu, B; Zhang, JX; Zheng, H	1
Fang, Y; Lin, BY; Pan, YR; Zhang, JX; Zheng, H	2
Chen, C; Chen, L; Dai, ZR; Ma, ZM; Zheng, XY	1
Chen, C; Guo, HZ; Zheng, XY	1
Fleck, SL; Peters, W; Robinson, BL	1
Peters, W; Robinson, BL	2
Basco, LK; Bickii, J; Ringwald, P; Same-Ekobo, A	1
Dutta, GP; Mishra, M; Puri, SK; Tripathi, R; Umesh, A	1
Awasthi, A; Dutta, GP; Mishra, M; Puri, SK; Tripathi, R	1
Ambroise-Thomas, P	1
Cai, Y; Ha, S; Shi, X; Yao, J; Ye, X	1
Chen, C; Gao, FH; Xia, Y; Zheng, XY	1
Chu, YH; Shao, BR; Ye, XY	2
Huang, ZS; Meng, F; Shao, BR; Shi, XH	1
Shao, BR; Ye, XY	1
Shao, BR	2
Chen, KY; Ha, SH; Lin, BY; Shao, BR; Ye, XY; Zhan, CQ; Zhang, JX	1
Shao, BR; Shi, XH; Ye, XY	1
Feng, Z; Guo, RN; Huang, ZS; Lin, X; Meng, F; Xing, QF; Zeng, LH; Zheng, Y	1
Chen, L; Dai, ZR; Fu, DD; Guo, FC; Liao, ZH; Ma, DQ; Ma, ZM; Pang, XJ; Qian, YL	1
Ha, SH; Huang, J; Huang, ZS; Meng, F; Shao, BR; Shi, XH; Ye, XY; Zhan, CQ	1
Shao, BR; Ye, XY; Zheng, H	1
Wu, LJ	2
Guo, RN; Huang, J; Huang, ZS; Li, X; Meng, F; Shao, BR; Shi, XH; Xing, QF; Ye, XY; Zeng, LH	1
Cai, XZ; Chen, QY; Fu, SG; Lin, KH; Liu, HH; Liu, QJ; Liu, XM; Liu, YP; Ou, FZ; Pang, XJ	1
Feng, Z; Gao, DQ; Liu, RJ; Qiu, CP; Wang, CY; Wu, ZF	1
Che, LG; Huang, KG; Huang, R; Lin, ZL; Yang, HL; Yu, L	1
Feng, Z; Jiang, NX; Wang, CY; Wu, ZF	1
Chen, KY; Ha, SH; Lin, BY; Shang, YZ; Shao, BR; Ye, XY; Zhan, CQ; Zhang, JX	1
Chen, L; Dai, ZR; Li, CJ; Qian, YL	1

Reviews

6 review(s) available for pyronaridine and Malaria

Article	Year
Pyronaridine: a review of its clinical pharmacology in the treatment of malaria. The Journal of antimicrobial chemotherapy, 2023, 10-03, Volume: 78, Issue:10 Topics: Antimalarials; Child; Chloroquine; Female; Humans; Malaria; Malaria, Falciparum; Naphthyridines; Pregnancy	2023
Animal Embryotoxicity Studies of Key Non-Artemisinin Antimalarials and Use in Women in the First Trimester. Birth defects research, 2017, Aug-15, Volume: 109, Issue:14 Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Drug Combinations; Female; Humans; Malaria; Malaria, Falciparum; Naphthyridines; Pregnancy; Pregnancy Trimester, First; Pyrimethamine; Quinine; Quinolines; Rabbits; Rats; Sulfadoxine; Teratogens	2017
New antimalarial drugs. Angewandte Chemie (International ed. in English), 2003, Nov-10, Volume: 42, Issue:43 Topics: Aminoquinolines; Animals; Antimalarials; Artemisinins; Artesunate; Atovaquone; Clinical Trials as Topic; Dapsone; Drug Combinations; Drug Design; Drug Resistance; Ethanolamines; Flavonoids; Fluorenes; Fosfomycin; Global Health; Humans; Lumefantrine; Malaria; Naphthoquinones; Naphthyridines; Plasmodium falciparum; Proguanil; Sesquiterpenes	2003
[Treatment of malaria: prevention of resistance by combinations of antimalarial agents]. Medecine tropicale : revue du Corps de sante colonial, 2000, Volume: 60, Issue:3 Topics: Animals; Antimalarials; Artemether; Artemisinins; Artesunate; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Mefloquine; Naphthyridines; Plasmodium; Sesquiterpenes	2000
A review of antimalarial drug pyronaridine. Chinese medical journal, 1990, Volume: 103, Issue:5 Topics: Animals; Antimalarials; Drug Therapy, Combination; Humans; Malaria; Naphthyridines; Plasmodium falciparum; Plasmodium vivax	1990
[Pyronaridine--a new antimalarial drug]. Zhonghua nei ke za zhi, 1985, Volume: 24, Issue:11 Topics: Animals; Antimalarials; Humans; Malaria; Naphthyridines; Plasmodium berghei; Plasmodium falciparum	1985

Trials

8 trial(s) available for pyronaridine and Malaria

Article	Year
Pyronaridine-artesunate or dihydroartemisinin-piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial. Lancet (London, England), 2018, 04-07, Volume: 391, Issue:10128 Topics: Adolescent; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Child; Child, Preschool; Drug Combinations; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Humans; Longitudinal Studies; Malaria; Male; Naphthyridines; Quinolines; Young Adult	2018
Safety and efficacy of re-treatments with pyronaridine-artesunate in African patients with malaria: a substudy of the WANECAM randomised trial. The Lancet. Infectious diseases, 2016, Volume: 16, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Artemisinins; Artesunate; Burkina Faso; Child; Child, Preschool; Drug Combinations; Female; Guinea; Humans; Infant; Malaria; Male; Mali; Middle Aged; Naphthyridines; Plasmodium; Retreatment; Treatment Outcome; Young Adult	2016
Population Pharmacokinetics of Pyronaridine in Pediatric Malaria Patients. Antimicrobial agents and chemotherapy, 2015, Dec-14, Volume: 60, Issue:3 Topics: Adolescent; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Child; Child, Preschool; Female; Humans; Infant; Malaria; Malaria, Falciparum; Malaria, Vivax; Male; Models, Theoretical; Naphthyridines	2015
Pyronaridine for treatment of Plasmodium ovale and Plasmodium malariae infections. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:10 Topics: Adolescent; Adult; Animals; Antimalarials; Child; Female; Humans; Malaria; Male; Naphthyridines; Plasmodium; Plasmodium malariae; Tablets, Enteric-Coated	1997
[Therapeutic effect of pyronaridine in plain tablets and enteric-coated tablets in falciparum malaria patients]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1989, Volume: 7, Issue:1 Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Humans; Malaria; Middle Aged; Naphthyridines; Plasmodium falciparum; Tablets; Tablets, Enteric-Coated	1989
[Observation on the efficacy of combined use of some new antimalarials for the treatment of falciparum malaria in Hainan Province]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1989, Volume: 7, Issue:2 Topics: Adolescent; Adult; Animals; Antimalarials; Drug Therapy, Combination; Female; Humans; Malaria; Male; Naphthyridines; Plasmodium falciparum; Quinazolines; Quinolines	1989
[Effects of combined dose of pyronaridine/sulfadoxine/pyrimethamine on falciparum malaria]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1988, Volume: 6, Issue:4 Topics: Adolescent; Adult; Animals; Antimalarials; Drug Therapy, Combination; Female; Humans; Malaria; Male; Naphthyridines; Plasmodium falciparum; Pyrimethamine; Sulfadoxine	1988
[Combined use of pyronaridine, sulfadoxine and primaquine in areas with chloroquine-resistant falciparum malaria]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1987, Volume: 5, Issue:3 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Naphthyridines; Plasmodium falciparum; Primaquine; Sulfadoxine; Sulfanilamides	1987

Other Studies

48 other study(ies) available for pyronaridine and Malaria

Article	Year
In vivo and in vitro efficacy of chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:1 Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Humans; Indonesia; Malaria; Male; Middle Aged; Plasmodium malariae; Plasmodium ovale; Treatment Outcome; Young Adult	2011
Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy. Journal of medicinal chemistry, 2016, 11-10, Volume: 59, Issue:21 Topics: Animals; Antimalarials; Disease Models, Animal; Drug Discovery; Malaria; Mice; Molecular Structure; Plasmodium falciparum; Quinolines; Structure-Activity Relationship	2016
Similarly efficacious anti-malarial drugs SJ733 and pyronaridine differ in their ability to remove circulating parasites in mice. Malaria journal, 2022, Feb-16, Volume: 21, Issue:1 Topics: Animals; Antimalarials; Drug Combinations; Heterocyclic Compounds, 4 or More Rings; Isoquinolines; Malaria; Mice; Naphthyridines; Parasites	2022
Quantification of the antimalarial drug pyronaridine in whole blood using LC-MS/MS - Increased sensitivity resulting from reduced non-specific binding. Journal of pharmaceutical and biomedical analysis, 2017, Nov-30, Volume: 146 Topics: Antimalarials; Artemisinins; Chromatography, Liquid; Cross-Over Studies; Drug Interactions; Formates; Humans; Malaria; Naphthyridines; Sensitivity and Specificity; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2017
Safety and efficacy of pyronaridine-artesunate in uncomplicated acute malaria: an integrated analysis of individual patient data from six randomized clinical trials. Malaria journal, 2013, Feb-21, Volume: 12 Topics: Adolescent; Adult; Africa; Antimalarials; Artemisinins; Artesunate; Asia; Child; Child, Preschool; Clinical Trials, Phase III as Topic; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Infant; Malaria; Malaria, Falciparum; Malaria, Vivax; Male; Middle Aged; Naphthyridines; Randomized Controlled Trials as Topic; Treatment Outcome; Young Adult	2013
Comparison of hematin-targeting properties of pynacrine, an acridine analog of the benzonaphthyridine antimalarial pyronaridine. Acta tropica, 2014, Volume: 140 Topics: Acridines; Antimalarials; Erythrocytes; Hemeproteins; Humans; Malaria; Naphthyridines; Plasmodium falciparum	2014
Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue. Proceedings of the National Academy of Sciences of the United States of America, 2011, Nov-22, Volume: 108, Issue:47 Topics: Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Blotting, Southern; Dose-Response Relationship, Drug; Ethanolamines; Fluorenes; Genetic Vectors; Germ Cells, Plant; Green Fluorescent Proteins; Luciferases; Lumefantrine; Malaria; Methylene Blue; Naphthyridines; Plasmodium falciparum; Quinolines; Sexual Development	2011
Selection and reversal of Plasmodium berghei resistance in the mouse model following repeated high doses of artemether. Parasitology research, 2004, Volume: 92, Issue:3 Topics: Animals; Antimalarials; Artemether; Artemisinins; Disease Models, Animal; Drug Resistance; Female; Immunity, Innate; Malaria; Male; Mice; Mice, Inbred Strains; Naphthyridines; Plasmodium berghei; Sesquiterpenes	2004
Anti-malarial efficacy of pyronaridine and artesunate in combination in vitro and in vivo. Acta tropica, 2008, Volume: 105, Issue:3 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Drug Resistance, Multiple; Drug Therapy, Combination; In Vitro Techniques; Inhibitory Concentration 50; Malaria; Mice; Naphthyridines; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Sesquiterpenes; Treatment Outcome	2008
[7 antimalarials in the treatment of mice experimentally infected with pyronaridine-resistant Plasmodium berghei]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1983, Volume: 4, Issue:4 Topics: Animals; Antimalarials; Drug Resistance; Drug Therapy, Combination; Female; Malaria; Male; Mice; Naphthyridines; Plasmodium berghei	1983
[The radical efficacy of pyronaridine-primaquine combination in tertian malaria]. Ji sheng chong xue yu ji sheng chong bing za zhi = Journal of parasitology & parasitic diseases, 1984, Volume: 2, Issue:4 Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Malaria; Male; Mice; Middle Aged; Naphthyridines; Plasmodium vivax; Primaquine	1984
[Observation on the efficacy of pyronaridine in vivax malaria]. Ji sheng chong xue yu ji sheng chong bing za zhi = Journal of parasitology & parasitic diseases, 1984, Volume: 2, Issue:4 Topics: Antimalarials; Humans; Malaria; Naphthyridines; Plasmodium vivax	1984
[A combined regimen of pyronaridin-artemether-chloroquine (PAC) for the treatment of Plasmodium cynomolgi infection in the rhesus monkey]. Yao xue xue bao = Acta pharmaceutica Sinica, 1984, Volume: 19, Issue:8 Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Drug Therapy, Combination; Macaca mulatta; Malaria; Naphthyridines; Pyrans; Sesquiterpenes	1984
[Clinical observations on pyronaridine phosphate by intravenous drip for the treatment of malaria]. Zhonghua nei ke za zhi, 1982, Volume: 21, Issue:11 Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Humans; Infusions, Parenteral; Malaria; Middle Aged; Naphthyridines; Plasmodium falciparum; Plasmodium vivax	1982
[Experimental studies on chemotherapeutic effects and toxicities of a new antimalarial drug 7351 (author's transl)]. Yao xue xue bao = Acta pharmaceutica Sinica, 1980, Volume: 15, Issue:10 Topics: Animals; Antimalarials; Cardiovascular System; Dogs; Haplorhini; Humans; Malaria; Mice; Naphthyridines; Rats	1980
[Clinical observations on the effect of malanidinum injection in the treatment of malaria]. Zhonghua yi xue za zhi, 1982, Volume: 62, Issue:11 Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Humans; Infant; Injections, Intramuscular; Malaria; Middle Aged; Naphthyridines	1982
[Polychemoresistant Plasmodium falciparum malaria, successfully treated with a benzonaphthyridine]. La Nouvelle presse medicale, 1982, Feb-27, Volume: 11, Issue:9 Topics: Adult; Antimalarials; Female; Humans; Malaria; Naphthyridines; Plasmodium falciparum	1982
[Studies on the establishment of malarial animal model of short-term relapse. IV. Short-term relapse in rhesus monkeys infected with sporozoites of Plasmodium cynomolgi]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1993, Volume: 11, Issue:4 Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Disease Models, Animal; Drug Therapy, Combination; Erythrocytes; Macaca mulatta; Malaria; Naphthyridines; Plasmodium cynomolgi; Recurrence; Sesquiterpenes	1993
[Studies on the establishment of malarial animal model of short-term relapse. III. Combined therapy with pyronaridine-artemether-chloroquine for parasitemia clearance]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1993, Volume: 11, Issue:3 Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Disease Models, Animal; Drug Therapy, Combination; Macaca mulatta; Malaria; Naphthyridines; Plasmodium cynomolgi; Recurrence; Sesquiterpenes	1993
[Studies on residual antimalarial activity of tripynadine in mice and monkeys]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1993, Volume: 11, Issue:3 Topics: Animals; Antimalarials; Macaca mulatta; Malaria; Mice; Naphthyridines; Plasmodium berghei; Plasmodium cynomolgi; Quinolines	1993
[Synthesis of pyronaridine related compounds and comparison of antimalarial activities]. Yao xue xue bao = Acta pharmaceutica Sinica, 1993, Volume: 28, Issue:8 Topics: Animals; Antimalarials; Malaria; Mice; Molecular Structure; Naphthyridines; Plasmodium berghei; Plasmodium yoelii	1993
Pyronaridine: yet another promising antimalarial substance from China. The Ceylon medical journal, 1996, Volume: 41, Issue:3 Topics: Antimalarials; China; Clinical Trials as Topic; Humans; Malaria; Naphthyridines	1996
The chemotherapy of rodent malaria. LIV. Combinations of 'Fenozan B07' (Fenozan-50F), a difluorinated 3,3'-spirocyclopentane 1,2,4-trioxane, with other drugs against drug-sensitive and drug-resistant parasites. Annals of tropical medicine and parasitology, 1997, Volume: 91, Issue:1 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Drug Antagonism; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Malaria; Mefloquine; Mice; Naphthyridines; Parasitemia; Phenanthrenes; Phenylpropionates; Plasmodium berghei; Plasmodium yoelii	1997
The chemotherapy of rodent malaria. LV. Interactions between pyronaridine and artemisinin. Annals of tropical medicine and parasitology, 1997, Volume: 91, Issue:2 Topics: Animals; Antimalarials; Artemisinins; Drug Combinations; Drug Resistance; Drug Synergism; Malaria; Mice; Naphthyridines; Plasmodium yoelii; Sesquiterpenes	1997
Plasmodium yoelii nigeriensis (MDR)-efficacy of oral pyronaridine against multidrug-resistant malaria in Swiss mice. Experimental parasitology, 2000, Volume: 94, Issue:3 Topics: Animals; Antimalarials; Drug Resistance, Multiple; Malaria; Mice; Naphthyridines; Plasmodium yoelii; Topoisomerase II Inhibitors	2000
Pyronaridine: an effective antimalarial against multidrug-resistant malaria. Life sciences, 2000, Jul-07, Volume: 67, Issue:7 Topics: Animals; Antimalarials; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Multiple; Malaria; Mice; Naphthyridines; Plasmodium yoelii	2000
[Determination of polyamines in pyronaridine-sensitive and -resistant Plasmodium berghei-infected erythrocytes]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1998, Volume: 16, Issue:2 Topics: Animals; Antimalarials; Drug Resistance; Erythrocytes; Female; Malaria; Male; Mice; Naphthyridines; Plasmodium berghei; Polyamines	1998
[Synthesis of 7351, a new antimalarial drug (author's transl)]. Yao xue xue bao = Acta pharmaceutica Sinica, 1979, Volume: 14, Issue:12 Topics: Animals; Antimalarials; Humans; Malaria; Naphthyridines	1979
The chemotherapy of rodent malaria. XLVII. Studies on pyronaridine and other Mannich base antimalarials. Annals of tropical medicine and parasitology, 1992, Volume: 86, Issue:5 Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Drug Resistance; Malaria; Mannich Bases; Mice; Naphthyridines; Plasmodium berghei; Plasmodium yoelii	1992
[Studies on the establishment of malarial animal model of short-term relapse. II. The phenomenon of sustained special ring form parasitemia in Plasmodium cynomolgi infection]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1992, Volume: 10, Issue:4 Topics: Aminoquinolines; Animals; Antimalarials; Disease Models, Animal; Macaca mulatta; Malaria; Naphthyridines; Plasmodium cynomolgi; Recurrence	1992
[The blood schizontocidal effects of pyronaridine, amodiaquine, mefloquine and qinghaosu on mice infected with Plasmodium berghei]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1992, Volume: 10, Issue:2 Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Drug Resistance; Female; Malaria; Male; Mefloquine; Mice; Naphthyridines; Plasmodium berghei; Sesquiterpenes	1992
Comparison of effects of pyronaridine, amodiaquine, mefloquine and qinghaosu on rodent malaria. The Southeast Asian journal of tropical medicine and public health, 1992, Volume: 23, Issue:1 Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Drug Administration Schedule; Drug Evaluation, Preclinical; Drug Resistance; Female; Malaria; Male; Mefloquine; Mice; Naphthyridines; Plasmodium berghei; Sesquiterpenes	1992
A 5-year surveillance of sensitivity in vivo of Plasmodium falciparum to pyronaridine/sulfadoxine/pyrimethamine in Diaoluo area, Hainan Province. The Southeast Asian journal of tropical medicine and public health, 1991, Volume: 22, Issue:1 Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; China; Drug Combinations; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Middle Aged; Naphthyridines; Plasmodium falciparum; Pyrimethamine; Sulfadoxine	1991
[Tissue schizontocidal action and acute toxicity of trifluoroacetyl primaquine]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:4 Topics: Aminoquinolines; Animals; Antimalarials; Drug Therapy, Combination; Female; Malaria; Male; Mice; Naphthyridines; Plasmodium yoelii; Primaquine	1990
Experimental studies on combinations of pyronaridine/primaquine versus chloroquine/primaquine. Chinese medical journal, 1990, Volume: 103, Issue:12 Topics: Animals; Antimalarials; Chloroquine; Drug Therapy, Combination; Macaca mulatta; Malaria; Mice; Naphthyridines; Plasmodium; Plasmodium yoelii; Primaquine	1990
[Combined action of pyronaridine and sulfadoxine/pyrimethamine against Plasmodium berghei ANKA strain in mice]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:1 Topics: Animals; Antimalarials; Drug Synergism; Drug Therapy, Combination; Female; Malaria; Male; Mice; Naphthyridines; Plasmodium berghei; Pyrimethamine; Sulfadoxine; Sulfanilamides	1990
Antimalarial and toxic effect of triple combination of pyronaridine, sulfadoxine and pyrimethamine. The Southeast Asian journal of tropical medicine and public health, 1989, Volume: 20, Issue:2 Topics: Animals; Antimalarials; Drug Therapy, Combination; Follow-Up Studies; Humans; Malaria; Mice; Naphthyridines; Plasmodium falciparum; Pyrimethamine; Rats; Sulfadoxine; Sulfanilamides	1989
[Stability of drug resistance of a pyronaridine-resistant line of Plasmodium berghei]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1985, Volume: 6, Issue:3 Topics: Animals; Antimalarials; Drug Resistance, Microbial; Female; Malaria; Male; Mice; Naphthyridines; Plasmodium berghei	1985
[Effect of pyronaridine on ultrastructure of erythrocytic forms of Plasmodium berghei in mice]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1985, Volume: 6, Issue:4 Topics: Animals; Antimalarials; Malaria; Mice; Naphthyridines; Plasmodium berghei	1985
[Efficacy of combined use of pyronaridine, sulfadoxine and pyrimethamine in the treatment of falciparum malaria on Hainan Island]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1988, Volume: 6, Issue:4 Topics: Adolescent; Adult; Animals; Antimalarials; Child; Drug Therapy, Combination; Humans; Malaria; Naphthyridines; Plasmodium falciparum; Pyrimethamine; Sulfadoxine	1988
[Determination of minimum effective concentration and proposed dosage regimen of pyronaridine in the treatment of malaria]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1988, Volume: 6, Issue:1 Topics: Animals; Antimalarials; Humans; Malaria; Naphthyridines; Plasmodium falciparum; Rabbits	1988
[Pharmacokinetics of pyronaridine in malaria patients]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1987, Volume: 8, Issue:6 Topics: Adult; Animals; Antimalarials; Biological Availability; Female; Humans; Malaria; Male; Microcomputers; Naphthyridines; Plasmodium falciparum; Plasmodium vivax	1987
[Toxicity and tissue schizontocidal activity of primaquine combined with pyronaridine in laboratory animals]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1988, Volume: 6, Issue:1 Topics: Animals; Antimalarials; Drug Therapy, Combination; Macaca mulatta; Malaria; Mice; Naphthyridines; Plasmodium yoelii; Primaquine; Rats	1988
[Suppressive effect of 3 combinations of antimalarials against Plasmodium cynomolgi]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1987, Volume: 5, Issue:4 Topics: Animals; Antimalarials; Drug Therapy, Combination; Macaca mulatta; Malaria; Naphthyridines; Quinazolines; Quinolines	1987
[Ultrastructural study on the effect of pyronaridine on the erythrocytic stages of chloroquine-resistant strain of Plasmodium berghei]. Ji sheng chong xue yu ji sheng chong bing za zhi = Journal of parasitology & parasitic diseases, 1986, Volume: 4, Issue:4 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Erythrocytes; Malaria; Mice; Naphthyridines; Plasmodium berghei	1986
[On the residual activity of pyronaridine against Plasmodium cynomolgi in rhesus monkeys]. Ji sheng chong xue yu ji sheng chong bing za zhi = Journal of parasitology & parasitic diseases, 1986, Volume: 4, Issue:2 Topics: Animals; Antimalarials; Macaca mulatta; Malaria; Naphthyridines; Plasmodium	1986
[Efficacy of pyronaridine in 510 acute malaria cases]. Zhonghua nei ke za zhi, 1985, Volume: 24, Issue:11 Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Female; Humans; Infant; Malaria; Male; Middle Aged; Naphthyridines; Plasmodium falciparum; Plasmodium vivax	1985
[Therapeutic effect of pyronaridine given intragastrically on Plasmodium cynomolgi-infected rhesus monkeys]. Yao xue xue bao = Acta pharmaceutica Sinica, 1985, Volume: 20, Issue:4 Topics: Animals; Antimalarials; Chloroquine; Macaca fascicularis; Macaca mulatta; Malaria; Naphthyridines; Recurrence	1985