pyroantimonate has been researched along with Coronary-Disease* in 1 studies
1 other study(ies) available for pyroantimonate and Coronary-Disease
| Article | Year |
|---|---|
The influence of nifedipine and mioflazine on mitochondrial calcium overload in normoxic and ischaemic guinea-pig hearts.
The influence of nifedipine (20 nM) and mioflazine (300 nM), i.e. concentrations inducing a 60-70% recovery of cardiac function during reperfusion of globally ischaemic guinea-pig working hearts, on the mitochondrial calcium content was investigated in normoxic, globally ischaemic and reperfused globally ischaemic guinea-pig working hearts. Mitochondrial calcium was determined electronmicroscopically with oxalate-pyroantimonate method. In normoxic hearts both nifedipine and mioflazine reduced the mitochondrial calcium content. Global ischaemia for 45 min and subsequent reperfusion for 25 min resulted in a pronounced mitochondrial calcium overload and damage to the cellular structure. In ischaemic and in reperfusion hearts the drugs maintained mitochondrial calcium at pre-ischaemic levels and decreased the damage to the cellular structure. Topics: Animals; Antimony; Calcium; Cardiovascular Agents; Coronary Disease; Guinea Pigs; Homeostasis; In Vitro Techniques; Mitochondria, Heart; Myocardial Reperfusion; Nifedipine; Oxalates; Piperazines | 1990 |