pyrithione has been researched along with Neuroblastoma in 2 studies
pyrithione: split from cephalosporin molecule; some metal complexes of this have fumarate reductase inhibitory activity and may be useful against trypanosomes; RN given refers to parent cpd; structure
pyrithione : A pyridinethione that is pyridine-2(1H)-thione in which the hydrogen attached to the nitrogen is replaced by a hydroxy group. It is a Zn(2+) ionophore; the zinc salt is used as an antifungal and antibacterial agent.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The iron chelator, deferoxamine, has demonstrated cytotoxicity against neuroblastoma cells." | 7.67 | Comparison of activity of deferoxamine with that of oral iron chelators against human neuroblastoma cell lines. ( Blatt, J; Kontoghiorghes, GJ; Taylor, SR, 1989) |
| "The iron chelator, deferoxamine, has demonstrated cytotoxicity against neuroblastoma cells." | 3.67 | Comparison of activity of deferoxamine with that of oral iron chelators against human neuroblastoma cell lines. ( Blatt, J; Kontoghiorghes, GJ; Taylor, SR, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Durham, HD | 1 |
| Dahrouge, S | 1 |
| Cashman, NR | 1 |
| Blatt, J | 1 |
| Taylor, SR | 1 |
| Kontoghiorghes, GJ | 1 |
2 other studies available for pyrithione and Neuroblastoma
| Article | Year |
|---|---|
Evaluation of the spinal cord neuron X neuroblastoma hybrid cell line NSC-34 as a model for neurotoxicity testing.
Topics: Action Potentials; Animals; Cell Line; Culture Media; Evaluation Studies as Topic; Glutamates; Gluta | 1993 |
Comparison of activity of deferoxamine with that of oral iron chelators against human neuroblastoma cell lines.
Topics: Administration, Oral; Cell Cycle; Cell Survival; Deferiprone; Deferoxamine; Humans; Hydroxybenzoates | 1989 |