pyrithione has been researched along with Leukemia in 1 studies
pyrithione: split from cephalosporin molecule; some metal complexes of this have fumarate reductase inhibitory activity and may be useful against trypanosomes; RN given refers to parent cpd; structure
pyrithione : A pyridinethione that is pyridine-2(1H)-thione in which the hydrogen attached to the nitrogen is replaced by a hydroxy group. It is a Zn(2+) ionophore; the zinc salt is used as an antifungal and antibacterial agent.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, we investigated the role of intracellular Zn level in the induction of apoptosis in human leukemia cells (HL-60 cells) using a Zn ionophore [pyrithione (Py)]." | 3.71 | Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells. ( Araragi, S; Higashimoto, M; Kondoh, M; Sato, M; Takiguchi, M; Tasaki, E; Watanabe, Y, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kondoh, M | 1 |
| Tasaki, E | 1 |
| Araragi, S | 1 |
| Takiguchi, M | 1 |
| Higashimoto, M | 1 |
| Watanabe, Y | 1 |
| Sato, M | 1 |
1 other study available for pyrithione and Leukemia
| Article | Year |
|---|---|
Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells.
Topics: Apoptosis; Blotting, Western; Caspases; Cell Death; Cell Line; Dose-Response Relationship, Drug; Enz | 2002 |