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pyrithione and Leukemia, Myelogenous, Chronic, BCR-ABL Positive

pyrithione has been researched along with Leukemia, Myelogenous, Chronic, BCR-ABL Positive in 2 studies

pyrithione: split from cephalosporin molecule; some metal complexes of this have fumarate reductase inhibitory activity and may be useful against trypanosomes; RN given refers to parent cpd; structure
pyrithione : A pyridinethione that is pyridine-2(1H)-thione in which the hydrogen attached to the nitrogen is replaced by a hydroxy group. It is a Zn(2+) ionophore; the zinc salt is used as an antifungal and antibacterial agent.

Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Muthyala, R1
Shin, WS1
Xie, J1
Sham, YY1
Lan, X1
Zhao, C1
Chen, X1
Zhang, P1
Zang, D1
Wu, J1
Chen, J1
Long, H1
Yang, L1
Huang, H1
Carter, BZ1
Wang, X1
Shi, X1
Liu, J1

Other Studies

2 other studies available for pyrithione and Leukemia, Myelogenous, Chronic, BCR-ABL Positive

ArticleYear
Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.
    Bioorganic & medicinal chemistry letters, 2015, Oct-01, Volume: 25, Issue:19

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Crystallography, X-Ray; Dose-Response

2015
Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms.
    Journal of hematology & oncology, 2016, 11-25, Volume: 9, Issue:1

    Topics: Apoptosis; Caspases; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Heterografts; Humans; Imat

2016