pyrimidinones and Thromboembolism

pyrimidinones has been researched along with Thromboembolism* in 1 studies

Other Studies

1 other study(ies) available for pyrimidinones and Thromboembolism

Article	Year
Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa. Bioorganic & medicinal chemistry letters, 2006, Oct-01, Volume: 16, Issue:19 Previously, potent factor Xa inhibitors were described based on the 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one bicyclic core and a 4-methoxyphenyl P1 moiety. This manuscript describes 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one and related bicyclic cores with the 3-aminobenzisoxazole P1 moiety. Many of these compounds are potent, selective, and efficacious inhibitors of coagulation factor Xa. Topics: Anticoagulants; Factor Xa Inhibitors; Humans; Pyrimidinones; Serine Proteinase Inhibitors; Structure-Activity Relationship; Substrate Specificity; Thromboembolism	2006

Article

Year

Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa.

Bioorganic & medicinal chemistry letters, 2006, Oct-01, Volume: 16, Issue:19

Previously, potent factor Xa inhibitors were described based on the 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one bicyclic core and a 4-methoxyphenyl P1 moiety. This manuscript describes 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one and related bicyclic cores with the 3-aminobenzisoxazole P1 moiety. Many of these compounds are potent, selective, and efficacious inhibitors of coagulation factor Xa.

Topics: Anticoagulants; Factor Xa Inhibitors; Humans; Pyrimidinones; Serine Proteinase Inhibitors; Structure-Activity Relationship; Substrate Specificity; Thromboembolism

2006